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Conserved domains on  [gi|564398659|ref|XP_006256772|]
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WD repeat domain phosphoinositide-interacting protein 4 isoform X1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
168-272 1.67e-09

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 1.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 168 GSLQLVDLASTKPGTssapfTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPATlyCINFS 247
Cdd:COG2319  226 GTVRLWDLATGKLLR-----TLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGGVN--SVAFS 297

                         90       100
                 ....*....|....*....|....*
gi 564398659 248 HDSSFLCASSDKGTVHIFALKDTRL 272
Cdd:COG2319  298 PDGKLLASGSDDGTVRLWDLATGKL 322
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-265 1.51e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 55.42  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659   8 GVTSLHFNQDQS--CFCCAMETgVRIYNVEPlmekGHLDHEQVGsvglvemlHRSNLLALVGGGSSPKF---SEISAVLI 82
Cdd:cd00200   11 GVTCVAFSPDGKllATGSGDGT-IKVWDLET----GELLRTLKG--------HTGPVRDVAASADGTYLasgSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659  83 WDDaregkdSKDKLVLEFT-FTKPVLAVRMRHDkivivlrNRIYVYSFPDNPRKLFEFDT-------RDNPKGLCDLCPS 154
Cdd:cd00200   78 WDL------ETGECVRTLTgHTSYVSSVAFSPD-------GRILSSSSRDKTIKVWDVETgkclttlRGHTDWVNSVAFS 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 155 LEKQLLVFpGHKCGSLQLVDLASTKPGTssapfTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRR 234
Cdd:cd00200  145 PDGTFVAS-SSQDGTIKLWDLRTGKCVA-----TLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTLRG 217

                        250       260       270
                 ....*....|....*....|....*....|.
gi 564398659 235 GTDPatLYCINFSHDSSFLCASSDKGTVHIF 265
Cdd:cd00200  218 HENG--VNSVAFSPDGYLLASGSEDGTIRVW 246
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
168-272 1.67e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 1.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 168 GSLQLVDLASTKPGTssapfTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPATlyCINFS 247
Cdd:COG2319  226 GTVRLWDLATGKLLR-----TLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGGVN--SVAFS 297

                         90       100
                 ....*....|....*....|....*
gi 564398659 248 HDSSFLCASSDKGTVHIFALKDTRL 272
Cdd:COG2319  298 PDGKLLASGSDDGTVRLWDLATGKL 322
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 188-275 7.13e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 7.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 188 TINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPATlyCINFSHDSSFLCASSDKGTVHIFAL 267
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKT-IKVWDVETGKCLTTLRGHTDWVN--SVAFSPDGTFVASSSQDGTIKLWDL 164


                 ....*...
gi 564398659 268 KDTRLNRR 275
Cdd:cd00200  165 RTGKCVAT 172
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-265 1.51e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.42  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659   8 GVTSLHFNQDQS--CFCCAMETgVRIYNVEPlmekGHLDHEQVGsvglvemlHRSNLLALVGGGSSPKF---SEISAVLI 82
Cdd:cd00200   11 GVTCVAFSPDGKllATGSGDGT-IKVWDLET----GELLRTLKG--------HTGPVRDVAASADGTYLasgSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659  83 WDDaregkdSKDKLVLEFT-FTKPVLAVRMRHDkivivlrNRIYVYSFPDNPRKLFEFDT-------RDNPKGLCDLCPS 154
Cdd:cd00200   78 WDL------ETGECVRTLTgHTSYVSSVAFSPD-------GRILSSSSRDKTIKVWDVETgkclttlRGHTDWVNSVAFS 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 155 LEKQLLVFpGHKCGSLQLVDLASTKPGTssapfTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRR 234
Cdd:cd00200  145 PDGTFVAS-SSQDGTIKLWDLRTGKCVA-----TLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTLRG 217

                        250       260       270
                 ....*....|....*....|....*....|.
gi 564398659 235 GTDPatLYCINFSHDSSFLCASSDKGTVHIF 265
Cdd:cd00200  218 HENG--VNSVAFSPDGYLLASGSEDGTIRVW 246
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
168-272 1.67e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 1.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 168 GSLQLVDLASTKPGTssapfTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPATlyCINFS 247
Cdd:COG2319  226 GTVRLWDLATGKLLR-----TLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGGVN--SVAFS 297

                         90       100
                 ....*....|....*....|....*
gi 564398659 248 HDSSFLCASSDKGTVHIFALKDTRL 272
Cdd:COG2319  298 PDGKLLASGSDDGTVRLWDLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
168-275 1.91e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 1.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 168 GSLQLVDLASTKPgtssaPFTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAtlYCINFS 247
Cdd:COG2319  184 GTVRLWDLATGKL-----LRTLTGHTGAVRSVAFSPDGKLLASGSADGT-VRLWDLATGKLLRTLTGHSGSV--RSVAFS 255

                         90       100
                 ....*....|....*....|....*...
gi 564398659 248 HDSSFLCASSDKGTVHIFALKDTRLNRR 275
Cdd:COG2319  256 PDGRLLASGSADGTVRLWDLATGELLRT 283
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 188-275 7.13e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 7.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 188 TINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPATlyCINFSHDSSFLCASSDKGTVHIFAL 267
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKT-IKVWDVETGKCLTTLRGHTDWVN--SVAFSPDGTFVASSSQDGTIKLWDL 164


                 ....*...
gi 564398659 268 KDTRLNRR 275
Cdd:cd00200  165 RTGKCVAT 172
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-265 1.51e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.42  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659   8 GVTSLHFNQDQS--CFCCAMETgVRIYNVEPlmekGHLDHEQVGsvglvemlHRSNLLALVGGGSSPKF---SEISAVLI 82
Cdd:cd00200   11 GVTCVAFSPDGKllATGSGDGT-IKVWDLET----GELLRTLKG--------HTGPVRDVAASADGTYLasgSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659  83 WDDaregkdSKDKLVLEFT-FTKPVLAVRMRHDkivivlrNRIYVYSFPDNPRKLFEFDT-------RDNPKGLCDLCPS 154
Cdd:cd00200   78 WDL------ETGECVRTLTgHTSYVSSVAFSPD-------GRILSSSSRDKTIKVWDVETgkclttlRGHTDWVNSVAFS 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 155 LEKQLLVFpGHKCGSLQLVDLASTKPGTssapfTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRR 234
Cdd:cd00200  145 PDGTFVAS-SSQDGTIKLWDLRTGKCVA-----TLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTLRG 217

                        250       260       270
                 ....*....|....*....|....*....|.
gi 564398659 235 GTDPatLYCINFSHDSSFLCASSDKGTVHIF 265
Cdd:cd00200  218 HENG--VNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
168-272 1.83e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 168 GSLQLVDLASTKPGTssapfTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPatLYCINFS 247
Cdd:COG2319  142 GTVRLWDLATGKLLR-----TLTGHSGAVTSVAFSPDGKLLASGSDDGT-VRLWDLATGKLLRTLTGHTGA--VRSVAFS 213

                         90       100
                 ....*....|....*....|....*
gi 564398659 248 HDSSFLCASSDKGTVHIFALKDTRL 272
Cdd:COG2319  214 PDGKLLASGSADGTVRLWDLATGKL 238
WD40 COG2319
WD40 repeat [General function prediction only];
168-272 2.07e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 2.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 168 GSLQLVDLASTKPgtssaPFTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPatLYCINFS 247
Cdd:COG2319  100 GTVRLWDLATGLL-----LRTLTGHTGAVRSVAFSPDGKTLASGSADGT-VRLWDLATGKLLRTLTGHSGA--VTSVAFS 171

                         90       100
                 ....*....|....*....|....*
gi 564398659 248 HDSSFLCASSDKGTVHIFALKDTRL 272
Cdd:COG2319  172 PDGKLLASGSDDGTVRLWDLATGKL 196
WD40 COG2319
WD40 repeat [General function prediction only];
168-269 2.43e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 2.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 168 GSLQLVDLASTKPgtssaPFTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPatLYCINFS 247
Cdd:COG2319  310 GTVRLWDLATGKL-----LRTLTGHTGAVRSVAFSPDGKTLASGSDDGT-VRLWDLATGELLRTLTGHTGA--VTSVAFS 381

                         90       100
                 ....*....|....*....|..
gi 564398659 248 HDSSFLCASSDKGTVHIFALKD 269
Cdd:COG2319  382 PDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
168-272 2.59e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 2.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 168 GSLQLVDLASTKPGTssapfTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPatLYCINFS 247
Cdd:COG2319  268 GTVRLWDLATGELLR-----TLTGHSGGVNSVAFSPDGKLLASGSDDGT-VRLWDLATGKLLRTLTGHTGA--VRSVAFS 339

                         90       100
                 ....*....|....*....|....*
gi 564398659 248 HDSSFLCASSDKGTVHIFALKDTRL 272
Cdd:COG2319  340 PDGKTLASGSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 187-272 5.58e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 5.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 187 FTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSkEKLVELRRG-TDPatLYCINFSHDSSFLCASSDKGTVHIF 265
Cdd:cd00200  129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGT-IKLWDLRT-GKCVATLTGhTGE--VNSVAFSPDGEKLLSSSSDGTIKLW 204


                 ....*..
gi 564398659 266 ALKDTRL 272
Cdd:cd00200  205 DLSTGKC 211
WD40 COG2319
WD40 repeat [General function prediction only];
169-272 6.94e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 6.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 169 SLQLVDLASTKPGTSSAPFTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPATlyCINFSH 248
Cdd:COG2319   54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGT-VRLWDLATGLLLRTLTGHTGAVR--SVAFSP 130

                         90       100
                 ....*....|....*....|....
gi 564398659 249 DSSFLCASSDKGTVHIFALKDTRL 272
Cdd:COG2319  131 DGKTLASGSADGTVRLWDLATGKL 154
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-266 1.85e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659   3 QQPLRGVTSLHFnqDQSCFCCAMETGVRIYNVEplmeKGHLDHEQVGSVGLVE--MLHRSNLLaLVGGGSSpkfseiSAV 80
Cdd:cd00200   51 TGPVRDVAASAD--GTYLASGSSDKTIRLWDLE----TGECVRTLTGHTSYVSsvAFSPDGRI-LSSSSRD------KTI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659  81 LIWDdareGKDSKDKLVLEfTFTKPVLAVRMRHDKIVIV--LRNR-IYVYSFPDN-PRKLFEFDTRDnpkgLCDLCPSLE 156
Cdd:cd00200  118 KVWD----VETGKCLTTLR-GHTDWVNSVAFSPDGTFVAssSQDGtIKLWDLRTGkCVATLTGHTGE----VNSVAFSPD 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 157 KQLLVFPGHKcGSLQLVDLASTKPGTssapfTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGT 236
Cdd:cd00200  189 GEKLLSSSSD-GTIKLWDLSTGKCLG-----TLRGHENGVNSVAFSPDGYLLASGSEDGT-IRVWDLRTGECVQTLSGHT 261

                        250       260       270
                 ....*....|....*....|....*....|
gi 564398659 237 DPATlyCINFSHDSSFLCASSDKGTVHIFA 266
Cdd:cd00200  262 NSVT--SLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 187-275 5.30e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.25  E-value: 5.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564398659 187 FTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPatLYCINFSHDSSFLCASSDKGTVHIFA 266
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGT-IKVWDLETGELLRTLKGHTGP--VRDVAASADGTYLASGSSDKTIRLWD 79


                 ....*....
gi 564398659 267 LKDTRLNRR 275
Cdd:cd00200   80 LETGECVRT 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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