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Conserved domains on  [gi|568914972|ref|XP_006498597|]
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cadherin-22 isoform X2 [Mus musculus]

Protein Classification

cadherin( domain architecture ID 10182681)

cadherin is a calcium-dependent cell adhesion protein that preferentially interacts with itself in a homophilic manner in connecting cells; it plays a crucial role in tissue morphogenesis and homeostasis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 621-680 2.54e-27

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 104.93  E-value: 2.54e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972  621 ADADLSVPPYDAFQTYAFEGAGSPAASLSSLHSGSTGSEQDFAFLRAWGPRFRPLAALYA 680
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 276-370 4.78e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 4.78e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972 276 LEVQEDAQVGSLVGVVTARDPDA-ANRPVRYAIDRDSDlEQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQ 354
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*.
gi 568914972 355 LSRASLRIRILDVNDN 370
Cdd:cd11304   83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-265 3.85e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 3.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972 157 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLreESGSGGDAFKVttdsDTQEAIIVVQKHLDFESQQVHTVVLEAL 236
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*....
gi 568914972 237 NKFVDPRFAdlgtfrdQAIVRVAVTDVDE 265
Cdd:cd11304   76 DGGGPPLSS-------TATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 377-475 1.41e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 1.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972 377 PYEAAVCEDAKPGQLIQTISVVDRDEPQGGhRFYFRLVPEAPSNpHFSlldIEDNTAAVHTQHvGFNRQEQDVFLLPILV 456
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDG-LFS---IDPSTGEITTAK-PLDREEQSSYTLTVTA 74

                         90
                 ....*....|....*....
gi 568914972 457 VDSGPPTLSSTGTLTIRIC 475
Cdd:cd11304   75 TDGGGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 63-148 6.30e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 6.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972  63 LQVMASDADDptyGSSARLVYSVLDG--EHHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATDMAGQlgGLSGSTTVTI 140
Cdd:cd11304   17 LTVSATDPDS---GENGEVTYSIVSGneDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATDGGGP--PLSSTATVTI 90


                 ....*...
gi 568914972 141 VVTDVNDN 148
Cdd:cd11304   91 TVLDVNDN 98
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 621-680 2.54e-27

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 104.93  E-value: 2.54e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972  621 ADADLSVPPYDAFQTYAFEGAGSPAASLSSLHSGSTGSEQDFAFLRAWGPRFRPLAALYA 680
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 276-370 4.78e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 4.78e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972 276 LEVQEDAQVGSLVGVVTARDPDA-ANRPVRYAIDRDSDlEQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQ 354
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*.
gi 568914972 355 LSRASLRIRILDVNDN 370
Cdd:cd11304   83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-265 3.85e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 3.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972 157 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLreESGSGGDAFKVttdsDTQEAIIVVQKHLDFESQQVHTVVLEAL 236
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*....
gi 568914972 237 NKFVDPRFAdlgtfrdQAIVRVAVTDVDE 265
Cdd:cd11304   76 DGGGPPLSS-------TATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 292-372 1.24e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 1.24e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972   292 TARDPDA-ANRPVRYAIDRDSDlEQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDN 370
Cdd:smart00112   1 SATDADSgENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 568914972   371 PP 372
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
277-365 6.71e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 6.71e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972  277 EVQEDAQVGSLVGVVTARDPD-AANRPVRYAIDRDsDLEQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQL 355
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDlGPNGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 568914972  356 SRASLRIRIL 365
Cdd:pfam00028  83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 377-475 1.41e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 1.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972 377 PYEAAVCEDAKPGQLIQTISVVDRDEPQGGhRFYFRLVPEAPSNpHFSlldIEDNTAAVHTQHvGFNRQEQDVFLLPILV 456
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDG-LFS---IDPSTGEITTAK-PLDREEQSSYTLTVTA 74

                         90
                 ....*....|....*....
gi 568914972 457 VDSGPPTLSSTGTLTIRIC 475
Cdd:cd11304   75 TDGGGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 63-148 6.30e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 6.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972  63 LQVMASDADDptyGSSARLVYSVLDG--EHHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATDMAGQlgGLSGSTTVTI 140
Cdd:cd11304   17 LTVSATDPDS---GENGEVTYSIVSGneDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATDGGGP--PLSSTATVTI 90


                 ....*...
gi 568914972 141 VVTDVNDN 148
Cdd:cd11304   91 TVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 67-150 4.23e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.76  E-value: 4.23e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972    67 ASDADDptyGSSARLVYSVLDGE--HHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATDMAGQlgGLSGSTTVTIVVTD 144
Cdd:smart00112   2 ATDADS---GENGKVTYSILSGNddGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGP--PLSSTATVTITVLD 75


                   ....*.
gi 568914972   145 VNDNPP 150
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
63-128 2.78e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 2.78e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568914972   63 LQVMASDADDPTygsSARLVYSVLDGE--HHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATDMAGQ 128
Cdd:pfam00028  16 LTVTATDPDLGP---NGRIFYSILGGGpgGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
378-475 6.89e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 6.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972  378 YEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLvpEAPSNPHFSlldIEDNTAAVHTQHVgFNRQEQDVFLLPILVV 457
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFR---IDPDTGDISTTKP-LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 568914972  458 DSGPPTLSSTGTLTIRIC 475
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
157-245 4.22e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 4.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972  157 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYhlREESGSGGDAFKVTTDSDTqeaiIVVQKHLDFESQQVHTVVLEAL 236
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY--SILGGGPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEAT 74


                  ....*....
gi 568914972  237 NKFVDPRFA 245
Cdd:pfam00028  75 DSGGPPLSS 83
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 175-267 5.09e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.29  E-value: 5.09e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972   175 KAEDSDVGENTDMTYHLreESGSGGDAFKVTTDSDtqeaIIVVQKHLDFESQQVHTVVLEALNKFVDPRFAdlgtfrdQA 254
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSS-------TA 67

                           90
                   ....*....|....
gi 568914972   255 IVRVAVTDV-DEPP 267
Cdd:smart00112  68 TVTITVLDVnDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 396-478 1.22e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 1.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972   396 SVVDRDEPQGGhRFYFRLVPEAPSNpHFSlldIEDNTAAVHTQHVgFNRQEQDVFLLPILVVDSGPPTLSSTGTLTIRIC 475
Cdd:smart00112   1 SATDADSGENG-KVTYSILSGNDDG-LFS---IDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ...
gi 568914972   476 GCD 478
Cdd:smart00112  75 DVN 77
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 621-680 2.54e-27

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 104.93  E-value: 2.54e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972  621 ADADLSVPPYDAFQTYAFEGAGSPAASLSSLHSGSTGSEQDFAFLRAWGPRFRPLAALYA 680
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 276-370 4.78e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 4.78e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972 276 LEVQEDAQVGSLVGVVTARDPDA-ANRPVRYAIDRDSDlEQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQ 354
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*.
gi 568914972 355 LSRASLRIRILDVNDN 370
Cdd:cd11304   83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-265 3.85e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 3.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972 157 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLreESGSGGDAFKVttdsDTQEAIIVVQKHLDFESQQVHTVVLEAL 236
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*....
gi 568914972 237 NKFVDPRFAdlgtfrdQAIVRVAVTDVDE 265
Cdd:cd11304   76 DGGGPPLSS-------TATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 292-372 1.24e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 1.24e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972   292 TARDPDA-ANRPVRYAIDRDSDlEQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDN 370
Cdd:smart00112   1 SATDADSgENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 568914972   371 PP 372
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
277-365 6.71e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 6.71e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972  277 EVQEDAQVGSLVGVVTARDPD-AANRPVRYAIDRDsDLEQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQL 355
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDlGPNGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 568914972  356 SRASLRIRIL 365
Cdd:pfam00028  83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 377-475 1.41e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 1.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972 377 PYEAAVCEDAKPGQLIQTISVVDRDEPQGGhRFYFRLVPEAPSNpHFSlldIEDNTAAVHTQHvGFNRQEQDVFLLPILV 456
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDG-LFS---IDPSTGEITTAK-PLDREEQSSYTLTVTA 74

                         90
                 ....*....|....*....
gi 568914972 457 VDSGPPTLSSTGTLTIRIC 475
Cdd:cd11304   75 TDGGGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 63-148 6.30e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 6.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972  63 LQVMASDADDptyGSSARLVYSVLDG--EHHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATDMAGQlgGLSGSTTVTI 140
Cdd:cd11304   17 LTVSATDPDS---GENGEVTYSIVSGneDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATDGGGP--PLSSTATVTI 90


                 ....*...
gi 568914972 141 VVTDVNDN 148
Cdd:cd11304   91 TVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 67-150 4.23e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.76  E-value: 4.23e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972    67 ASDADDptyGSSARLVYSVLDGE--HHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATDMAGQlgGLSGSTTVTIVVTD 144
Cdd:smart00112   2 ATDADS---GENGKVTYSILSGNddGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGP--PLSSTATVTITVLD 75


                   ....*.
gi 568914972   145 VNDNPP 150
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
63-128 2.78e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 2.78e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568914972   63 LQVMASDADDPTygsSARLVYSVLDGE--HHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATDMAGQ 128
Cdd:pfam00028  16 LTVTATDPDLGP---NGRIFYSILGGGpgGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
378-475 6.89e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 6.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972  378 YEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLvpEAPSNPHFSlldIEDNTAAVHTQHVgFNRQEQDVFLLPILVV 457
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFR---IDPDTGDISTTKP-LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 568914972  458 DSGPPTLSSTGTLTIRIC 475
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
157-245 4.22e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 4.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972  157 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYhlREESGSGGDAFKVTTDSDTqeaiIVVQKHLDFESQQVHTVVLEAL 236
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY--SILGGGPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEAT 74


                  ....*....
gi 568914972  237 NKFVDPRFA 245
Cdd:pfam00028  75 DSGGPPLSS 83
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 175-267 5.09e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.29  E-value: 5.09e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972   175 KAEDSDVGENTDMTYHLreESGSGGDAFKVTTDSDtqeaIIVVQKHLDFESQQVHTVVLEALNKFVDPRFAdlgtfrdQA 254
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSS-------TA 67

                           90
                   ....*....|....
gi 568914972   255 IVRVAVTDV-DEPP 267
Cdd:smart00112  68 TVTITVLDVnDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 396-478 1.22e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 1.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914972   396 SVVDRDEPQGGhRFYFRLVPEAPSNpHFSlldIEDNTAAVHTQHVgFNRQEQDVFLLPILVVDSGPPTLSSTGTLTIRIC 475
Cdd:smart00112   1 SATDADSGENG-KVTYSILSGNDDG-LFS---IDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ...
gi 568914972   476 GCD 478
Cdd:smart00112  75 DVN 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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