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Conserved domains on  [gi|568924755|ref|XP_006502480|]
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WD repeat-containing protein 47 isoform X11 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
607-918 3.26e-53

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 3.26e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 607 TQAVRAVAFHPSGSLYAVGSNSKTLRVcaypekMDASAHDNPKQPvvrfkrnKHHKGSIYCVAWSPCGQLLATGSNDKYV 686
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 687 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFmegpeSG-GAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALy 765
Cdd:COG2319  145 RLWDLATGKLLRTLTG-------HSGAVTSVAF-----SPdGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSV- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 766 TWS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHP 843
Cdd:COG2319  211 AFSpdGKLLASGSADGTVRLWDLATGKLLR----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568924755 844 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPlmvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 918
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 45-102 1.02e-12

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 63.36  E-value: 1.02e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568924755    45 FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS 102
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
LisH_TPL super family cl39307
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 13-40 3.37e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


The actual alignment was detected with superfamily member pfam17814:

Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.61  E-value: 3.37e-05
                          10        20
                  ....*....|....*....|....*...
gi 568924755   13 EIIKLILDFLNSKKLHISMLALEKESGV 40
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
607-918 3.26e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 3.26e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 607 TQAVRAVAFHPSGSLYAVGSNSKTLRVcaypekMDASAHDNPKQPvvrfkrnKHHKGSIYCVAWSPCGQLLATGSNDKYV 686
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 687 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFmegpeSG-GAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALy 765
Cdd:COG2319  145 RLWDLATGKLLRTLTG-------HSGAVTSVAF-----SPdGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSV- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 766 TWS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHP 843
Cdd:COG2319  211 AFSpdGKLLASGSADGTVRLWDLATGKLLR----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568924755 844 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPlmvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 918
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 600-918 3.74e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.38  E-value: 3.74e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 600 CINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRVCAYpekmdasahdnpkQPVVRFKRNKHHKGSIYCVAWSPCGQLLA 678
Cdd:cd00200    1 LRRTLKGhTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-------------ETGELLRTLKGHTGPVRDVAASADGTYLA 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 679 TGSNDKYVKVLPFNAETCNATVSGpdlefsmHDGTIRDLAFMEGPEsggaiLISAGAGDCNIYTTDCQRGQGLHALSGHT 758
Cdd:cd00200   68 SGSSDKTIRLWDLETGECVRTLTG-------HTSYVSSVAFSPDGR-----ILSSSSRDKTIKVWDVETGKCLTTLRGHT 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 759 GHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRM 837
Cdd:cd00200  136 DWVNSVaFSPDGTFVASSSQDGTIKLWDLRTGKCVA----TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 838 VQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQgdltKQLPLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTL 917
Cdd:cd00200  212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR----TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287


                 .
gi 568924755 918 W 918
Cdd:cd00200  288 W 288
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 45-102 1.02e-12

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 63.36  E-value: 1.02e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568924755    45 FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS 102
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 659-688 1.87e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.87e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 568924755   659 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 688
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
659-688 1.63e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.63e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 568924755  659 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 688
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 13-40 3.37e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.61  E-value: 3.37e-05
                          10        20
                  ....*....|....*....|....*...
gi 568924755   13 EIIKLILDFLNSKKLHISMLALEKESGV 40
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 767-921 1.86e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 767 WSGWM---IASGSQDKTVRFWDLRVPSCVrvvgTTFHGTGSAVASV---AVDPSgrLLATGQEDSSCMLYDIRGGRMVQS 840
Cdd:PLN00181 540 WNSYIksqVASSNFEGVVQVWDVARSQLV----TEMKEHEKRVWSIdysSADPT--LLASGSDDGSVKLWSINQGVSIGT 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 841 YHPhSSDVRSVRF-SPGAHYLLTGSYDMKIKVTDLQgdlTKQLPLMVVGEHKDKVIQCRWhTQDLSFLSSSADRTVTLWT 919
Cdd:PLN00181 614 IKT-KANICCVQFpSESGRSLAFGSADHKVYYYDLR---NPKLPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWD 688


                 ..
gi 568924755 920 YS 921
Cdd:PLN00181 689 LS 690
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 9-42 3.79e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 35.87  E-value: 3.79e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568924755     9 VKEVEIIKLILDFLNSKKLHISMLALEKESGVIN 42
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
607-918 3.26e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 3.26e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 607 TQAVRAVAFHPSGSLYAVGSNSKTLRVcaypekMDASAHDNPKQPvvrfkrnKHHKGSIYCVAWSPCGQLLATGSNDKYV 686
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 687 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFmegpeSG-GAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALy 765
Cdd:COG2319  145 RLWDLATGKLLRTLTG-------HSGAVTSVAF-----SPdGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSV- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 766 TWS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHP 843
Cdd:COG2319  211 AFSpdGKLLASGSADGTVRLWDLATGKLLR----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568924755 844 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPlmvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 918
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
607-918 4.00e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.89  E-value: 4.00e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 607 TQAVRAVAFHPSGSLYAVGSNSKTLRVcaypekMDASAhdnpKQPVVRFKrnkHHKGSIYCVAWSPCGQLLATGSNDKYV 686
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGSADGTVRL------WDLAT----GKLLRTLT---GHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 687 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFmeGPEsgGAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALyT 766
Cdd:COG2319  187 RLWDLATGKLLRTLTG-------HTGAVRSVAF--SPD--GKLLASGSA-DGTVRLWDLATGKLLRTLTGHSGSVRSV-A 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 767 WS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPH 844
Cdd:COG2319  254 FSpdGRLLASGSADGTVRLWDLATGELLR----TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 329

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568924755 845 SSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGdltkQLPLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 918
Cdd:COG2319  330 TGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT----GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 600-918 3.74e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.38  E-value: 3.74e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 600 CINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRVCAYpekmdasahdnpkQPVVRFKRNKHHKGSIYCVAWSPCGQLLA 678
Cdd:cd00200    1 LRRTLKGhTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-------------ETGELLRTLKGHTGPVRDVAASADGTYLA 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 679 TGSNDKYVKVLPFNAETCNATVSGpdlefsmHDGTIRDLAFMEGPEsggaiLISAGAGDCNIYTTDCQRGQGLHALSGHT 758
Cdd:cd00200   68 SGSSDKTIRLWDLETGECVRTLTG-------HTSYVSSVAFSPDGR-----ILSSSSRDKTIKVWDVETGKCLTTLRGHT 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 759 GHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRM 837
Cdd:cd00200  136 DWVNSVaFSPDGTFVASSSQDGTIKLWDLRTGKCVA----TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 838 VQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQgdltKQLPLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTL 917
Cdd:cd00200  212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR----TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287


                 .
gi 568924755 918 W 918
Cdd:cd00200  288 W 288
WD40 COG2319
WD40 repeat [General function prediction only];
600-876 4.84e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.26  E-value: 4.84e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 600 CINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRVCaypekmDASAHdnpkQPVVRFKrnkHHKGSIYCVAWSPCGQLLA 678
Cdd:COG2319  154 LLRTLTGhSGAVTSVAFSPDGKLLASGSDDGTVRLW------DLATG----KLLRTLT---GHTGAVRSVAFSPDGKLLA 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 679 TGSNDKYVKVLPFNAETCNATVSGpdlefsmHDGTIRDLAFMegpeSGGAILISAGAgDCNIYTTDCQRGQGLHALSGHT 758
Cdd:COG2319  221 SGSADGTVRLWDLATGKLLRTLTG-------HSGSVRSVAFS----PDGRLLASGSA-DGTVRLWDLATGELLRTLTGHS 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 759 GHILALyTWS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGR 836
Cdd:COG2319  289 GGVNSV-AFSpdGKLLASGSDDGTVRLWDLATGKLLR----TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568924755 837 MVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQG 876
Cdd:COG2319  364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
661-918 6.51e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.62  E-value: 6.51e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATVSGpdlefsmHDGTIRDLAFmegpESGGAILISAGAgDCNI 740
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG-------HTGAVRSVAF----SPDGKTLASGSA-DGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 741 YTTDCQRGQGLHALSGHTGHILALyTWS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLL 818
Cdd:COG2319  145 RLWDLATGKLLRTLTGHSGAVTSV-AFSpdGKLLASGSDDGTVRLWDLATGKLLR----TLTGHTGAVRSVAFSPDGKLL 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 819 ATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLplmvVGEHKDKVIQCR 898
Cdd:COG2319  220 ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT----LTGHSGGVNSVA 295

                        250       260
                 ....*....|....*....|
gi 568924755 899 WHTQDLSFLSSSADRTVTLW 918
Cdd:COG2319  296 FSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 600-831 2.25e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.53  E-value: 2.25e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 600 CINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRVcaypekmdasaHDNPK-QPVVRFKrnkHHKGSIYCVAWSPCGQLL 677
Cdd:cd00200   85 CVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKV-----------WDVETgKCLTTLR---GHTDWVNSVAFSPDGTFV 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 678 ATGSNDKYVKVLPFNAETCNATvsgpdleFSMHDGTIRDLAFMEgpeSGGAILISAGAGDCNIYttDCQRGQGLHALSGH 757
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVAT-------LTGHTGEVNSVAFSP---DGEKLLSSSSDGTIKLW--DLSTGKCLGTLRGH 218

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568924755 758 TGHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 831
Cdd:cd00200  219 ENGVNSVaFSPDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 597-785 3.57e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.87  E-value: 3.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 597 QFVCINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRVCaypekmDASAHdnpkQPVVRFKrnkHHKGSIYCVAWSPCGQ 675
Cdd:cd00200  124 TGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKLW------DLRTG----KCVATLT---GHTGEVNSVAFSPDGE 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 676 LLATGSNDKYVKVLPFNAETCNATVSGpdlefsmHDGTIRDLAFMEGPEsggaiLISAGAGDCNIYTTDCQRGQGLHALS 755
Cdd:cd00200  191 KLLSSSSDGTIKLWDLSTGKCLGTLRG-------HENGVNSVAFSPDGY-----LLASGSEDGTIRVWDLRTGECVQTLS 258

                        170       180       190
                 ....*....|....*....|....*....|..
gi 568924755 756 GHTGHILALyTWS--GWMIASGSQDKTVRFWD 785
Cdd:cd00200  259 GHTNSVTSL-AWSpdGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
725-918 1.02e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.59  E-value: 1.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 725 SGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTG 803
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLaASPDGARLAAGAGDLTLLLLDAAAGALLA----TLLGHT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 804 SAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQL 882
Cdd:COG2319   79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKLLRTL 158

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 568924755 883 PlmvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 918
Cdd:COG2319  159 T-----GHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 45-102 1.02e-12

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 63.36  E-value: 1.02e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568924755    45 FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS 102
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 844-922 7.28e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 7.28e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568924755 844 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLtkqlPLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYSG 922
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE----LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 659-688 1.87e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.87e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 568924755   659 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 688
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
659-688 1.63e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.63e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 568924755  659 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 688
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 835-873 2.54e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 2.54e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568924755   835 GRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 873
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
835-873 8.53e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 8.53e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568924755  835 GRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 873
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 748-785 1.58e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.58e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568924755   748 GQGLHALSGHTGHILALyTWS--GWMIASGSQDKTVRFWD 785
Cdd:smart00320   2 GELLKTLKGHTGPVTSV-AFSpdGKYLASGSDDGTIKLWD 40
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 13-40 3.37e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.61  E-value: 3.37e-05
                          10        20
                  ....*....|....*....|....*...
gi 568924755   13 EIIKLILDFLNSKKLHISMLALEKESGV 40
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 767-921 1.86e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 767 WSGWM---IASGSQDKTVRFWDLRVPSCVrvvgTTFHGTGSAVASV---AVDPSgrLLATGQEDSSCMLYDIRGGRMVQS 840
Cdd:PLN00181 540 WNSYIksqVASSNFEGVVQVWDVARSQLV----TEMKEHEKRVWSIdysSADPT--LLASGSDDGSVKLWSINQGVSIGT 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924755 841 YHPhSSDVRSVRF-SPGAHYLLTGSYDMKIKVTDLQgdlTKQLPLMVVGEHKDKVIQCRWhTQDLSFLSSSADRTVTLWT 919
Cdd:PLN00181 614 IKT-KANICCVQFpSESGRSLAFGSADHKVYYYDLR---NPKLPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWD 688


                 ..
gi 568924755 920 YS 921
Cdd:PLN00181 689 LS 690
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 793-848 7.47e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 7.47e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568924755  793 RVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDV 848
Cdd:pfam12894  28 RVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLI 83
WD40 pfam00400
WD domain, G-beta repeat;
751-785 9.36e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 9.36e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568924755  751 LHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWD 785
Cdd:pfam00400   4 LKTLEGHTGSVTSLaFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 798-831 1.45e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.45e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568924755   798 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 831
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
797-831 1.92e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.92e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568924755  797 TTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 831
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 597-633 3.26e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 3.26e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568924755   597 QFVCINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRV 633
Cdd:smart00320   1 SGELLKTLKGhTGPVTSVAFSPDGKYLASGSDDGTIKL 38
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 9-42 3.79e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 35.87  E-value: 3.79e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568924755     9 VKEVEIIKLILDFLNSKKLHISMLALEKESGVIN 42
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 883-918 6.06e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 6.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568924755   883 PLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 918
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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