|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
13-396 |
3.67e-119 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 351.91 E-value: 3.67e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 13 IIILTYVLAALELTCLFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYL 92
Cdd:cd17331 1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 93 LLVASCSpalpgVFLLFASRIPSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPA 172
Cdd:cd17331 81 LLAFASS-----VPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 173 ILAFVVTLLGAVLSFTCVPATTKEASVQSAPQGGTKASVFDLKAITRLLLLPRVLPVFLVKVISGLPSGpgitaglllyp 252
Cdd:cd17331 156 LVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIG----------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 253 gLFLVMFSIISMDFFQLEAAQAGYLMSFFGILQMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFL 332
Cdd:cd17331 225 -MFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVL 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568952692 333 MPGLVFSLCTLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYGVPIFGH 396
Cdd:cd17331 304 LLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGL 367
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
18-390 |
1.13e-43 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 155.81 E-value: 1.13e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 18 YVLAALELTCLFMQFSILPYLSR---TLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLL 94
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVRefnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 95 VASCSPAlpgvFLLFASRIPSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAIL 174
Cdd:cd17330 82 GLSRNLW----LLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 175 AFVVTLLGAVLSFTCVPattkeasvqsapqggtkasvfdlkaitrllllpRVLPVFLVKVISGLPSGpgitaglllypgL 254
Cdd:cd17330 158 AAALALLNLVLVLFFLP---------------------------------PLRRLLLVYFLIALAFA------------G 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 255 FLVMFSIISMDFFQLEAAQAGYLMSFFGILQMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFLMP 334
Cdd:cd17330 193 LESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAA 272
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 568952692 335 GLVFSLCTLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 390
Cdd:cd17330 273 ILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLG 328
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
18-386 |
8.92e-30 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 118.10 E-value: 8.92e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 18 YVLAALELTCLFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVAS 97
Cdd:cd17390 2 YLVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 98 CSpalpgVFLLFASRIPSALM-HTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTL-NTAYGIQCPAILA 175
Cdd:cd17390 82 TS-----LALLFLSRIPLGIFkHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLaETDGGFYYVALLC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 176 FVVTLLGAVLSFTCVPattkeasvqsapqggtkaSVFDLkaitrllllprvlpvFLVKVISGLpsgpgitAGLLLYPglf 255
Cdd:cd17390 157 SAIFILNAGLVWFLLS------------------KLWDL---------------LLVRFLMGF-------SVLLFRS--- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 256 lvMFSIISMDFFQLEAAQAGYLMSFFGILQMmIQGLVIGRLSTHFPEE---ALLRSSVLVFAVVgLGMALMSSVLHFCFL 332
Cdd:cd17390 194 --NFSLYLEERFDLSPKTIGYLISYSGVLGA-LSGFLVGRILKLYKNNeylLLLHSFILLALSL-LGLALAPSIWLLVLC 269
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 568952692 333 MPGLVFSLCTLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLY 386
Cdd:cd17390 270 LTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQ 323
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-392 |
7.39e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 90.33 E-value: 7.39e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 18 YVLAALELTCLFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVAS 97
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 98 CSPALPgVFLLFASRIPSALmhTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFV 177
Cdd:cd17325 82 TSYWQL-LLARFLQGLASAA--VWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 178 VTLLGAVLSFTCVPATTKEASVQSAPQGGTKASVFDLkaitrlLLLPRVLPVFLVKVISGLPSgpgitaglllypGLFLV 257
Cdd:cd17325 159 LALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLL------LRDRRLLALFLAIFVLAFAF------------GALEP 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 258 MFSIISMDFFQLEAAQAGYLMSFFGILQMMIQGLViGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFLMPGLV 337
Cdd:cd17325 221 FLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPA-GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLG 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 568952692 338 FSLCTLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYGVP 392
Cdd:cd17325 300 LGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA 354
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
12-386 |
2.16e-17 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 83.07 E-value: 2.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 12 GIIILTYVLAALELTcLFMqfSILPYLSRTLGLDSVS----FGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSflAA 87
Cdd:cd17388 2 IFILVTVLLDAMGIG-LIM--PVLPTLLREFVGDSADaathYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLS--LA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 88 SALYLLLVASCSPALPgvfLLFASRIPSALM-HTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNtAY 166
Cdd:cd17388 77 GAALDYLLMAFAPTLW---WLYLGRIIAGITgATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLG-EI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 167 GIQCPAILAFVVTLLGAVLSFTCVPATTKEASVQSAPQGGTKAsvfdlkaitrlllLPRVLPVFLVKVISGLpsgpgITA 246
Cdd:cd17388 153 SPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANP-------------FGSLRWLTGFPGLLGL-----LAV 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 247 GLLLYPGLFLVM--FSIISMDFFQLEAAQAGYLMSFFGILQMMIQGLVIGRLSTHFPEEallRSSVLVFAVVGLGMALMS 324
Cdd:cd17388 215 FFLIQLIGQVPAttWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEK---RAILLGLAADALGFLLLA 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568952692 325 SVLHFCFLMPGLVFsLCTLNVVT---DSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLY 386
Cdd:cd17388 292 FATQGWMVFPILIL-LALGGIAGpalQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIF 355
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-371 |
3.36e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 79.25 E-value: 3.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 4 SMAALPRQGIIILTYVLAALELTCLFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLS 83
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 84 FLAASALYLLLVAScspalPGVFLLFASRIPSALMHTL--PAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGT 161
Cdd:COG2814 82 LLLFALGSLLCALA-----PSLWLLLAARFLQGLGAGAlfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 162 LNTAYGIQCPAILAFVVTLLGAVLSFTCVPATTKEAsvqSAPQGGTKASVFDLKAITRLLllprvlpvflvkvisglpsg 241
Cdd:COG2814 157 LADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAA---RARLRGSLRELLRRPRLLLLL-------------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 242 pGITAGLLLYPGLFLVMFSIISMDFFQLEAAQAGYLMSFFGILqMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMA 321
Cdd:COG2814 214 -LLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLG-GVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 568952692 322 LMSSVLHFCFLMPGLVFSLCTLNVVTDSMLTKAVSASDTGTMLGLSASVQ 371
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-379 |
1.03e-13 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 71.68 E-value: 1.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 14 IILTYVLAALELTCLFmqFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLL 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLG--PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 94 LVAScspalPGVFLLFASRIPSALMH--TLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCP 171
Cdd:pfam07690 79 LLFA-----SSLWLLLVLRVLQGLGAgaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 172 AILAFVVTLLGAVLSFTCVPATTKEASVQSAPQGGTKASVFdlkaitrllllprvlpvflvKVISGLPSGPGITAGLLLY 251
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW--------------------KALLRDPVLWLLLALLLFG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 252 PGLFLVMFSI-ISMDFFQLEAAQAGYLMSFFGILqMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFC 330
Cdd:pfam07690 214 FAFFGLLTYLpLYQEVLGLSALLAGLLLGLGGLL-GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSL 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 568952692 331 FLMPGLV---FSLCTLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGP 379
Cdd:pfam07690 293 WLLLALLllgFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
45-390 |
1.29e-09 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 59.60 E-value: 1.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 45 DSVSFG-YLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVASCSPalpGVFLLfaSRIPSALMH-TLP 122
Cdd:cd17389 61 NSVLFGgLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSF---TIFLL--SRIVGGISKgNVS 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 123 AAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGG---TLNTAYGI---QCPAILAFVVTLLGAVLSFTCVPATtke 196
Cdd:cd17389 136 LSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAyfaSFTRSLGEvffSMPALFALVLALADLLFIFFFLPET--- 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 197 asvqsapqggtkasvfdlkaitrllllprvlpvflvkvisgLPSGPGITAG-----LLLYPGL-FLVMFsiISMDFFQLE 270
Cdd:cd17389 213 -----------------------------------------LPSNLRRLGLvyflyLFLFSGLeFTLTF--LTHQRFQYT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 271 AAQAGYLMSFFGILQMMIQGLVIGRLSTHFPEEALLRSSVLVF-AVVGLGMALMSSVLHFCFLMpglvFSLCTLNVVT-- 347
Cdd:cd17389 250 SMQQGKMFFFIGIIMALVQGGYVRRIKPGKEKKAVLQGLILLIpAFLLIGWASSVTVLYAGLFL----YSFAAATVVPcl 325
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 568952692 348 DSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 390
Cdd:cd17389 326 TTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAG 368
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-386 |
1.51e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 56.28 E-value: 1.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 18 YVLAALELTCLFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFlaaSALYLLLVAS 97
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGL---LLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 98 CSPALPGVFLLFASRIPSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAF- 176
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIa 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 177 -VVTLLGAVLSFTCVPATTKEASVQSAPQGGTKasvfdlkaitrllllpRVLPVFLVKVISGLPSGPGITAGLLLYPGLF 255
Cdd:cd06174 159 aALALLAAILLLLVVPDPPESARAKNEEASSKS----------------VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 256 LVMFSIISMDFFQLEAAQAGYLMSFFGILQMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFLMPG 335
Cdd:cd06174 223 STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLL 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 568952692 336 LVFSLCTLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLY 386
Cdd:cd06174 303 LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
30-393 |
7.99e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.77 E-value: 7.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 30 MQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVASCSPALPGVFLLF 109
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 110 ASRIPSALMHTL--PAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFVVTLLGAVLSF 187
Cdd:cd06173 97 VLAFLLGIASAFfgPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 188 TCVPATTKEASVQSAPQGGTKASVFdlkaitrllllprvlpvFLVKVISGLPSGPGITAGLLLYPGLFLVMFSIISMDFF 267
Cdd:cd06173 177 FIRRPPPAAPGESSSLLLRDLREGL-----------------RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 268 QLEAAQAGYLMSFFGIlQMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFLMPGLVFSLCTLNVVT 347
Cdd:cd06173 240 GGGAAGYGLLLAAFGV-GALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPL 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 568952692 348 DSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYGVPI 393
Cdd:cd06173 319 NTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
37-390 |
3.96e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.84 E-value: 3.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 37 YLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVASCSPALPGVFLLFASrIPSA 116
Cdd:cd17329 25 YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTG-FGGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 117 LMHtlPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLnTAYGIQCPAILAFVVTLLGAVLSFTCVPAT-TK 195
Cdd:cd17329 104 LFE--PASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLFLAAAVLFLLAALVLLFLLPETrPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 196 EASVQSAPQGGTKASVFDLKAITrllllprvlpvflvkvisglpsgpgitaglllypgLFLVMFSIISMDFFQLEAAQAG 275
Cdd:cd17329 181 RRAAEKTEILRGYKIVLRDRAFL-----------------------------------LFLLASFLISLIYFQLESTLPV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 276 YLMSFFGILQMMIQGLV-------------IGRLSTHFPEEALLRSSVLVFAV----VGLGMALMSSVLHFCFLMPGLVF 338
Cdd:cd17329 226 YVVEILGLGESLLGLLLalnallivllqfpVARLVERFRLRKILMIGILLFAIgfavLAFANTLAVLILAMIVLTLGEML 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 568952692 339 SLCTLNVVTDSMltkaVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 390
Cdd:cd17329 306 VFPAVQTLVAAL----APPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG 353
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
34-390 |
2.11e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 49.49 E-value: 2.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 34 ILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAAsalylllvascspALPGVFLLFASRI 113
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLF-------------GIGGLLCGLSDSF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 114 PSALM----------HTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLnTAYGIQCPAILAFVVTLLGA 183
Cdd:cd17474 88 ALLLAgralqgigaaGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 184 VLSFTCVPATTKEASVQSAPQGGTKASVFDLKAitrllllprvlpvFLVKVISGLpsgpgitAGLLLYpGLFLVMFSIIS 263
Cdd:cd17474 167 LAILFLLPEPKEKAKSSSATKLRDLKKALRGRG-------------LLTFLVSAF-------LYFFLY-FAFLTYLPFLL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 264 MDFFQLEAAQAGYLMSFFGILqMMIQGLVIGRLSTH-FPEEALLRSSVLVFAVVGLGMALMSSVLhfCFLMPGLVFSLC- 341
Cdd:cd17474 226 ELLYGISPIIIGLLFAGWSVL-LALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLA--LLLIAIVLFGLGl 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 568952692 342 -TLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 390
Cdd:cd17474 303 gLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG 352
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-298 |
3.26e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 48.65 E-value: 3.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 2 SGSMAALPRQGIIILTYVLAALELTCLFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALS 81
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 82 LSFLAASALYLllvasCSPALPGVFLLFASRIPSALMHTL--PAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLG 159
Cdd:COG0477 84 IGLLLFGLASL-----LCGLAPSPELLIAARALQGIGAGGlmPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 160 GTLNTAYGIQCPAILAFVVTLLGAVLSFTCVPatTKEASVQSAPQGGTKASVFDLKAITRLLLLPRVLPVFLVKVISGLP 239
Cdd:COG0477 159 GLLVAALGWRWIFLINAPLGLLALVLRLRLPE--SRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAG 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 568952692 240 SGPGITAGLLLYPGLFLVMFSIISMDFFQLEAAQAGYLMSFFGILQMMIQGLVIGRLST 298
Cdd:COG0477 237 AALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
34-390 |
2.17e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.40 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 34 ILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVAScspalPGVFLLFASRI 113
Cdd:COG2271 32 AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFA-----TSFWQLLLLRF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 114 PSALMH--TLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFVVTLLGAVLSFTCVp 191
Cdd:COG2271 107 LLGLGEagFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWLL- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 192 attkeasvqsapqggtkasvfdlkaitrllllprvlpvflvkvisglpsgpgITAGLLLYPGLFLVMFSIIS--MDFFQL 269
Cdd:COG2271 186 ----------------------------------------------------ALAYFLVYFALYGFLTWLPTylVEVRGL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 270 EAAQAGYLMSFFGILqMMIQGLVIGRLSTHFPEE--ALLRSSVLVFAVVGLGMALMSSVLHFCFLMPGLVFSLCTLNVVT 347
Cdd:COG2271 214 SLAQAGLLLSLPFLA-GIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLL 292
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 568952692 348 DSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 390
Cdd:COG2271 293 WALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
29-390 |
2.71e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.03 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 29 FMQFSIL-PYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAAsalylllvascspALPGVFL 107
Cdd:COG2223 21 WYLWSVLaPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL-------------GIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 108 LFASRIPSALMH----------TLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFV 177
Cdd:COG2223 88 ALAVSYWLLLLLglllgiggggSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 178 VTLLGAVLSFTCVPATTKEASVQSapqggtKASVFDLKAITRLLLLPRVLPVFLVKVISGLPsgpgitaglllypglFLV 257
Cdd:COG2223 168 LLLVVAVLAWLFLRDPPAGAAAAA------KASLRDQLEALRDPRFWLLSLLYFGTFGSFIG---------------FSS 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 258 MFSIISMDFFQLEAAQAGYLMSFFGILQMMIqGLVIGRLSTHFPEEALLrssVLVFAVVGLGMALMSSVLH----FCFLM 333
Cdd:COG2223 227 WLPPYLVDQFGLSAATAGLLAALFALLGALG-RPLGGWLSDRIGGRRVL---LIVFALMALGLLLLALALGslwlFLVLF 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 568952692 334 PGLVFSLCTLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 390
Cdd:COG2223 303 LLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG 359
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
3-187 |
4.73e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 45.23 E-value: 4.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 3 GSMAALPRQGIIILTYVLAALELTCLFMQFSIL-PYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALS 81
Cdd:cd17324 189 SSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLaPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 82 LSFLAASALYLLLVASCSP--ALPGVFLLFAsripsALMHTLPAAQMVITDLtAPTERPAALGRLGLCFGIGIIFGSLLG 159
Cdd:cd17324 269 ALLLLAAALLLLTLLGPSPllLLVGLVLWGL-----GFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALG 342
|
170 180
....*....|....*....|....*...
gi 568952692 160 GTLNTAYGIQCPAILAFVVTLLGAVLSF 187
Cdd:cd17324 343 GLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
30-394 |
5.69e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.88 E-value: 5.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 30 MQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVAScsPALPgvFLLF 109
Cdd:cd17504 14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA--PNLP--VLIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 110 ASRIPSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQcpaiLAFVVTLLGAVLSFTC 189
Cdd:cd17504 90 GRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWR----WIFWTAAPVAVLLAAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 190 VPATTKEASVQsapqggtkASVFDLKAITRLLLLPRVLPVFLVKVISGLPSGPGitaglllypglflvmfsiismdfFQL 269
Cdd:cd17504 166 VPLIDLRLLRR--------RNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTG-----------------------FGL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 270 EAAQAGYLMSFFGILqMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFLMPGLV---FSLCTLNVV 346
Cdd:cd17504 215 GITEAGLLLLPGALV-MLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIgigLGLAFASLP 293
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 568952692 347 TdsMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYGVPIF 394
Cdd:cd17504 294 N--IVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSIT 339
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
29-329 |
1.36e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.74 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 29 FMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVAScspalPGVFLL 108
Cdd:cd17489 13 YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA-----TSVALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 109 FASRIPSALMH--TLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFVVTLLGAVLS 186
Cdd:cd17489 88 LVLRLIHGIGWgaFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 187 FTcVPATTKEASVQSAPQGGTKASVFDLKAITrllllprvlpvflvkvisglpsgpgITAGLLLYPGLFLVMFSIISMDF 266
Cdd:cd17489 168 FL-VKDPPPVAAEEAEAGTRAFRRLVEKKVLP-------------------------PALILFLASIAYGAISTFLPLYA 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568952692 267 FQLEAAQAGYLMSFFGILqMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHF 329
Cdd:cd17489 222 AERGISNAGLFFTVYAIA-LLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWML 283
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-195 |
2.22e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.93 E-value: 2.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 13 IIILTYVLAALELTCLFMQFSIL----PYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAAS 88
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALYGFLtwlpTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 89 ALYLLLVASCSPALPGVFLLFASrIPSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGI 168
Cdd:COG2271 258 AALALLLLALLPSPALAIALLFL-AGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
|
170 180
....*....|....*....|....*..
gi 568952692 169 QCPAILAFVVTLLGAVLSFTCVPATTK 195
Cdd:COG2271 337 QAAFLLLAALALLAALLALLLLRETRK 363
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
33-325 |
2.92e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.92 E-value: 2.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 33 SILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVAScspalPGVFLLFASR 112
Cdd:COG0738 29 PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA-----PSYPLLLLAL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 113 IPSALMHTL--PAAQMVITDLTaPTERPAALGRLGLCFGIGIIFGSLLGGTL---NTAYGIQCP-AILAFVVTLLGAVLS 186
Cdd:COG0738 104 FLLGLGLGLldVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLillGLSLSWHLPyLILAVLLLLLALLFL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 187 FTCVPATTKEASvQSAPQGGTKASVFDLKAITRllllprvlpvflvkvisglpsgpgITAGLLLYPGLFLVMFSIIS--- 263
Cdd:COG0738 183 RSKLPEIEEEEE-EAAGSAASLKSLLKNPRLLL------------------------GGLAIFLYVGAEGAIGDWLPlyl 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568952692 264 MDFFQLEAAQAGYLMSFFGILqMMIQGLVIGRLSTHFPEEALLRSSvLVFAVVGLGMALMSS 325
Cdd:COG0738 238 KDVLGLSEATAALGLSLFWGG-MTIGRFLGGFLLKRFGPVRLLRLS-ALLAAVGLLLALLAP 297
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
128-390 |
1.10e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.04 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 128 ITDLTA-PTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPA---ILAFVVTLLGAVLSFTCVpATTKEASVQSAP 203
Cdd:COG2211 135 GAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALgyrLTALIFAVLGLLAFLLTF-FGTKERPVPEEE 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 204 QGGTKASVFDLKAITRLLLLPRVLPVFLVkvisglpsGPGITAGLLLYpglFLVmfsiismDFFQLEAAQAGYLMSFFGI 283
Cdd:COG2211 214 KVSLKESLKALLKNRPFLLLLLAYLLFFL--------ALALVAALLLY---YFK-------YVLGLSAALVGLLLALYFL 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 284 LQMMIQgLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALM--SSVLHFCFLMPGLVFSLCTLNVVTDSMLTKAVSASD-- 359
Cdd:COG2211 276 AALLGA-PLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwk 354
|
250 260 270
....*....|....*....|....*....|....*.
gi 568952692 360 -----TGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 390
Cdd:COG2211 355 tgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
33-217 |
2.11e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.91 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 33 SILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLlvascSPALPGVFLLFASR 112
Cdd:cd17328 20 GVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL-----SSFAPNFWQLLLFR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 113 IPSALMHTL--PAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTA-YGIQCPAILAFVVTLLGAVLSFTC 189
Cdd:cd17328 95 ALVGIGEASysPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLF 174
|
170 180
....*....|....*....|....*....
gi 568952692 190 VPATTKEASVQSAPQGGTKASVF-DLKAI 217
Cdd:cd17328 175 VREPPRGAAEGGVMAKSTATSFLaDLKAL 203
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
10-188 |
2.99e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.52 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 10 RQGIIILTYVLAALELTCLFMQFSILPYLSR-TLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAAS 88
Cdd:cd06173 206 RSPLLRLLLLALALFALLGGALTVLLPLLAKeVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 89 ALYLLLVASCSPALPGVFLLFASripSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGI 168
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLG---LAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL 362
|
170 180
....*....|....*....|
gi 568952692 169 QCPAILAFVVTLLGAVLSFT 188
Cdd:cd06173 363 SAVFLLAGALLLLAALLLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
267-390 |
3.03e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.57 E-value: 3.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 267 FQLEAAQAGYLMSFFGILQMMIQgLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFLMPGLVFSLCTLNVV 346
Cdd:COG2814 40 LGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPA 118
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 568952692 347 TDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 390
Cdd:COG2814 119 ALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
13-390 |
3.48e-03 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 39.50 E-value: 3.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 13 IIILTYVLAALELTCLFMqfSILPYLSR-TLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCG-ARAALSLSFLAASAL 90
Cdd:cd17326 3 VMYLTMFLSSLQFSIVLT--SIWPYLQKiDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 91 YLLLVASCSPALPGVFLLFASRIPSAL-MHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTA---- 165
Cdd:cd17326 81 NILYALAEYFPSNRKYVMLVARFLIGVgAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIgypg 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 166 YGIQC---------PAILAFVVTLLGAVLSFTCVpattKEASVqsapqggtkasvfdlkaitrllLLPRVLPVFLVKVIS 236
Cdd:cd17326 161 YVIGIklrfnmytaPAWLMAILGIINIILILFFF----KEVVC----------------------IFLFFVVLFIFANLE 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 237 glpsgpgitaglllypglflVMFSIISMDFFQLEAAQA----GYLMSFFGILQmMIQGLVIGRLSTHFPEEALLRSSVLV 312
Cdd:cd17326 215 --------------------TIGTPLTMDMYGWTREEAvlynGIILAVSGVLS-VLVFLLFKFLSLGLIDERKILLGGLI 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 313 FAVVGLgmaLMSSVLHFCFlmpGLVFSLC--TLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 390
Cdd:cd17326 274 LFFLGF---VVTLPWGITG---VILFGLGypIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFG 347
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
28-392 |
3.93e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.07 E-value: 3.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 28 LFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLllvasCSPALPGVFL 107
Cdd:cd17324 15 EYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL-----LAALAPSFAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 108 LFASRIPSALMHTL--PAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFVVTLLGAVL 185
Cdd:cd17324 90 LLLARALAGLAHGGfwAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 186 SFTCVPATTKEASVQSAPQGGTKASVFDlkaitrllllprvlpvflvkvisglPSGPGITAGLLLYPGLFLVMFSIIS-- 263
Cdd:cd17324 170 LWRLLPSLPPKKPGSLGLLSSLLLLLRN-------------------------PRLRLAYLITFLLFGGFFALYTYLApf 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 264 -MDFFQLEAAQAGYLMSFFGILqMMIQGLVIGRLSTHFPEEALLrSSVLVFAVVGLGMALMSSVLHFCFLMPGLVFSLCT 342
Cdd:cd17324 225 lTDVPGFSSSAIIGLLLLFGVA-GVVGSPLAGRLADRGGRRALL-IALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 568952692 343 LNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYGVP 392
Cdd:cd17324 303 AAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWA 352
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
28-185 |
9.84e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 37.94 E-value: 9.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952692 28 LFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVASCSPALPGVFL 107
Cdd:COG2223 222 IGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVL 301
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568952692 108 LFAsrIPSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFVVTLLGAVL 185
Cdd:COG2223 302 FLL--LGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALV 377
|
|
| |
