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Conserved domains on  [gi|568966007|ref|XP_006513002|]
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adenylate kinase 9 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1381-1553 4.99e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.46  E-value: 4.99e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1381 RIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCNT 1460
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1461 iGVVIDGYPVTPHQMDLLE---ARSIIPMVIFELHVPSKEIFKRLL---LEKKTEQSMSYPLHNSSQIIAYKNA------ 1528
Cdd:cd01428    79 -GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERILgrrICPVSGRVYHLGKDDVTGEPLSQRSddneet 157

                         170       180       190
                  ....*....|....*....|....*....|.
gi 568966007 1529 ------KYHKNINEIRQFYQKQhQNWHVIDG 1553
Cdd:cd01428   158 ikkrleVYKEQTAPLIDYYKKK-GKLVEIDG 187
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 962-1177 7.51e-22

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 95.00  E-value: 7.51e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  962 RICLLGPHGSGKTVCARKLAENFGIFHIQFDEFLQEKMLLKaerkfgpefeddseeeqlvkqeleelaaqanvkieedtt 1041
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASG--------------------------------------- 41

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1042 kkqlpdvqlTEEEEAIKLSLTDNEPLPSEILDSILSEWwLKEPIRSTGFILDGFPRHPEEAQFLGE---RGFFPDAAVII 1118
Cdd:cd01428    42 ---------TELGKKAKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALDElldEGIKPDKVIEL 111

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1119 QVDDQDIFDRLLPAQVQKWKTKQHKKLERKKLIKDLKTKIKEDM-VAKRRAELILEREKK 1177
Cdd:cd01428   112 DVPDEVLIERILGRRICPVSGRVYHLGKDDVTGEPLSQRSDDNEeTIKKRLEVYKEQTAP 171
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 34-277 9.59e-17

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member cd01428:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 194  Bit Score: 80.36  E-value: 9.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   34 FIIFGKPGAGKTTLARNIAQAWKCIRVEALSVLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSPEVAHfGY 113
Cdd:cd01428     2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK-GF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  114 ILTEMP-SLAQdnmtsLKQIELVKNLELQPDIIINIKCSDYDLCQRTCGQRQHSTTGYVYTREQWDPEIIEsrrrkkrdf 192
Cdd:cd01428    81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHLGKDDVTGEP--------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  193 pkegkseeeeeeeeqeeeeafiaemqmvaeilqhLVQRPEDYLENVEITVKLYKELLLSALEEVMaehNPQYLIELDGNK 272
Cdd:cd01428   147 ----------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                  ....*
gi 568966007  273 SPEEL 277
Cdd:cd01428   190 DIDEV 194
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 899-954 6.72e-07

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


:

Pssm-ID: 442578  Cd Length: 56  Bit Score: 47.78  E-value: 6.72e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568966007  899 GDTKHFCPVVlkeNFVLQPGNPDEAVKYREKIYYFSSTEAKEKFLEHPEDYVSQNE 954
Cdd:COG3350     3 GVAMVIDPVC---GMTVDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1381-1553 4.99e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.46  E-value: 4.99e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1381 RIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCNT 1460
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1461 iGVVIDGYPVTPHQMDLLE---ARSIIPMVIFELHVPSKEIFKRLL---LEKKTEQSMSYPLHNSSQIIAYKNA------ 1528
Cdd:cd01428    79 -GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERILgrrICPVSGRVYHLGKDDVTGEPLSQRSddneet 157

                         170       180       190
                  ....*....|....*....|....*....|.
gi 568966007 1529 ------KYHKNINEIRQFYQKQhQNWHVIDG 1553
Cdd:cd01428   158 ikkrleVYKEQTAPLIDYYKKK-GKLVEIDG 187
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 962-1177 7.51e-22

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 95.00  E-value: 7.51e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  962 RICLLGPHGSGKTVCARKLAENFGIFHIQFDEFLQEKMLLKaerkfgpefeddseeeqlvkqeleelaaqanvkieedtt 1041
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASG--------------------------------------- 41

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1042 kkqlpdvqlTEEEEAIKLSLTDNEPLPSEILDSILSEWwLKEPIRSTGFILDGFPRHPEEAQFLGE---RGFFPDAAVII 1118
Cdd:cd01428    42 ---------TELGKKAKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALDElldEGIKPDKVIEL 111

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1119 QVDDQDIFDRLLPAQVQKWKTKQHKKLERKKLIKDLKTKIKEDM-VAKRRAELILEREKK 1177
Cdd:cd01428   112 DVPDEVLIERILGRRICPVSGRVYHLGKDDVTGEPLSQRSDDNEeTIKKRLEVYKEQTAP 171
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1381-1503 3.71e-18

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 84.98  E-value: 3.71e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  1381 RIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCNT 1460
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKA--GTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNE 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 568966007  1461 IGVVIDGYPVTPHQMDLLEARSIIPM-VIFELHVPSKEIFKRLL 1503
Cdd:TIGR01351   79 NGFILDGFPRTLSQAEALDALLEEPIdAVIELDVPDEELVERLS 122
AAA_17 pfam13207
AAA domain;
1385-1506 5.84e-17

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 79.21  E-value: 5.84e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  1385 VGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNnhpDSELSLMLNwHLHKGKTVPDELAIQALDISLMESVCNTiGVV 1464
Cdd:pfam13207    1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAK---ERGLVEDRD-EMRKLPLEPQKELQKLAAERIAEEAGEG-GVI 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 568966007  1465 IDGYPVTPHQMDLLEA------RSIIPMVIFELHVPSKEIFKRLLLEK 1506
Cdd:pfam13207   76 VDGHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKDR 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 34-277 9.59e-17

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 80.36  E-value: 9.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   34 FIIFGKPGAGKTTLARNIAQAWKCIRVEALSVLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSPEVAHfGY 113
Cdd:cd01428     2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK-GF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  114 ILTEMP-SLAQdnmtsLKQIELVKNLELQPDIIINIKCSDYDLCQRTCGQRQHSTTGYVYTREQWDPEIIEsrrrkkrdf 192
Cdd:cd01428    81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHLGKDDVTGEP--------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  193 pkegkseeeeeeeeqeeeeafiaemqmvaeilqhLVQRPEDYLENVEITVKLYKELLLSALEEVMaehNPQYLIELDGNK 272
Cdd:cd01428   147 ----------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                  ....*
gi 568966007  273 SPEEL 277
Cdd:cd01428   190 DIDEV 194
adk PRK00279
adenylate kinase; Reviewed
 1381-1503 2.30e-16

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 79.81  E-value: 2.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1381 RIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCNT 1460
Cdd:PRK00279    2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKA--GTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKN 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568966007 1461 iGVVIDGYPVTPHQMDLLEA----RSI-IPMVIfELHVPSKEIFKRLL 1503
Cdd:PRK00279   80 -GFLLDGFPRTIPQAEALDEmlkeLGIkLDAVI-EIDVPDEELVERLS 125
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1381-1503 3.05e-16

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 79.40  E-value: 3.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1381 RIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSEL-----SLMlnwhlHKGKTVPDELAIQALDISLME 1455
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKA--GTELgkkakEYM-----DAGELVPDEIVIGLVKERLAQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568966007 1456 SVCNTiGVVIDGYPVTPHQMD----LLEARSIIPMVIFELHVPSKEIFKRLL 1503
Cdd:COG0563    75 PDCAN-GFILDGFPRTVAQAEaldeLLAELGIKLDAVIELDVDDEELVERLS 125
PLN02842 PLN02842
nucleotide kinase
 35-278 9.43e-14

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 76.05  E-value: 9.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   35 IIFGKPGAGKTTLARNIAQAWKCIRVEALSVLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSPEVAHFGYI 114
Cdd:PLN02842    1 MISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  115 LTEMPSlaqdnmtSLKQIELVKNLELQPDIIINIKCSDYDLCQRTCGQRQHSTTGYVYtreqwdpeiiesrrrKKRDFPK 194
Cdd:PLN02842   81 LDGYPR-------SFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIY---------------HIKNFPP 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  195 EGKseeeeeeeeqeeeeafiaemqmvaEILQHLVQRPEDYLENVEITVKLYK---ELLLSALEEVMaehnpqylIELDGN 271
Cdd:PLN02842  139 ESE------------------------EIKARLITRPDDTEEKVKARLQIYKknaEAILSTYSDIM--------VKIDGN 186


                  ....*..
gi 568966007  272 KSPEELF 278
Cdd:PLN02842  187 RPKEVVF 193
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 34-172 4.53e-13

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 70.16  E-value: 4.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   34 FIIFGKPGAGKTTLARNIAQAWKcirVEALS---VLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSPEVAH 110
Cdd:COG0563     3 IILLGPPGAGKGTQAKRLAEKYG---IPHIStgdMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCAN 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568966007  111 fGYILTEMP-SLAQdnMTSLKqiELVKNLELQPDIIINIKCSDYDLCQRTCGQRQHSTTGYVY 172
Cdd:COG0563    80 -GFILDGFPrTVAQ--AEALD--ELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATY 137
ADK pfam00406
Adenylate kinase;
36-172 5.33e-13

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 69.26  E-value: 5.33e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007    36 IFGKPGAGKTTLARNIAQAWKCIRVEALSVLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSPEVAHfGYIL 115
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKN-GFLL 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568966007   116 TEMP-SLAQDNmtSLKQIELvknLELQPDIIINIKCSDYDLCQRTCGQRQHSTTGYVY 172
Cdd:pfam00406   80 DGFPrTVPQAE--ALEELLE---RGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSY 132
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 962-1130 2.40e-11

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 65.15  E-value: 2.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  962 RICLLGPHGSGKTVCARKLAENFGIFHIQF-DeflqekmLLKAERKfgpefeDDSEEEQLVKQELE--ELaaqanvkiee 1038
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTgD-------MLRAAVK------AGTELGKKAKEYMDagEL---------- 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1039 dttkkqLPDvqlteeeeaiklsltdneplpsEILDSILsEWWLKEPIRSTGFILDGFPRHPEEAQFL----GERGFFPDA 1114
Cdd:COG0563    59 ------VPD----------------------EIVIGLV-KERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDA 109

                         170
                  ....*....|....*.
gi 568966007 1115 AVIIQVDDQDIFDRLL 1130
Cdd:COG0563   110 VIELDVDDEELVERLS 125
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 962-1130 1.73e-09

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 59.56  E-value: 1.73e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   962 RICLLGPHGSGKTVCARKLAENFGIFHIQFDEFLQEKMllKAERKFGPEFEDDSEEEQLVkqeleelaaqanvkieedtt 1041
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEI--KAGTPLGKKAKEYMEKGELV-------------------- 58

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  1042 kkqlpdvqlteeeeaiklsltdneplPSEILDSILSEWWLKEPIRSTGFILDGFPRHPEEAQFLGERGFFP-DAAVIIQV 1120
Cdd:TIGR01351   59 --------------------------PDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALDALLEEPiDAVIELDV 112

                          170
                   ....*....|
gi 568966007  1121 DDQDIFDRLL 1130
Cdd:TIGR01351  113 PDEELVERLS 122
AAA_17 pfam13207
AAA domain;
966-1130 2.16e-08

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 54.55  E-value: 2.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   966 LGPHGSGKTVCARKLAENFGIFHIQF-DEFLQEkmllkAERKFGPEFEDDSEEEQLVKQEleELAAQANVKIEEDTTKKq 1044
Cdd:pfam13207    1 TGVPGSGKTTQLKKLAEKLGFPHISAgDLLREE-----AKERGLVEDRDEMRKLPLEPQK--ELQKLAAERIAEEAGEG- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  1045 lpdvqlteeeeaiklsltdneplpseildsilsewwlkepirstGFILDGFPRHPEEAQFLGE------RGFFPDAAVII 1118
Cdd:pfam13207   73 --------------------------------------------GVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILL 108

                          170
                   ....*....|..
gi 568966007  1119 QVDDQDIFDRLL 1130
Cdd:pfam13207  109 EADPEEILERRL 120
adk PRK00279
adenylate kinase; Reviewed
 961-1130 2.28e-07

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 53.62  E-value: 2.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  961 LRICLLGPHGSGKTVCARKLAENFGIFHIQF-DeflqekmLLKAErkfgpefeddseeeqlVKQElEELAaqanVKIEED 1039
Cdd:PRK00279    1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTgD-------MLRAA----------------VKAG-TELG----KEAKSY 52

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1040 TTKKQLpdvqlteeeeaiklsltdnepLPSEILDSILSEWwLKEPIRSTGFILDGFPRHPEEAQ----FLGERGFFPDAA 1115
Cdd:PRK00279   53 MDAGEL---------------------VPDEIVIGLVKER-LAQPDCKNGFLLDGFPRTIPQAEaldeMLKELGIKLDAV 110

                         170
                  ....*....|....*
gi 568966007 1116 VIIQVDDQDIFDRLL 1130
Cdd:PRK00279  111 IEIDVPDEELVERLS 125
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 899-954 6.72e-07

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 47.78  E-value: 6.72e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568966007  899 GDTKHFCPVVlkeNFVLQPGNPDEAVKYREKIYYFSSTEAKEKFLEHPEDYVSQNE 954
Cdd:COG3350     3 GVAMVIDPVC---GMTVDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 904-950 1.17e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 43.02  E-value: 1.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 568966007   904 FCPVVL-KENFVLQPGNPDEAV-KYREKIYYFSSTEAKEKFLEHPEDYV 950
Cdd:pfam12018  201 FCAWTLvVRDGLLLPGNPSIGVlKYKDKYYAFSSKEAAYEFASDPDRFI 249
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 1382-1466 4.95e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 39.66  E-value: 4.95e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   1382 IMIVGPPKSGKTTVAKKLASDYGLRCLSVgdaLRGMLNNHPDSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCNTI 1461
Cdd:smart00382    5 ILIVGPPGSGKTTLARALARELGPPGGGV---IYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDV 81


                    ....*
gi 568966007   1462 gVVID 1466
Cdd:smart00382   82 -LILD 85
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
 1382-1419 5.40e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 39.40  E-value: 5.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568966007 1382 IMIVGPPKSGKTTVAKKLASDYGLRCLSVGDAL-RGMLN 1419
Cdd:NF033453   19 ILLVGPPGSGKTALLRELAAKRGAPVINVNLELsRRLLE 57
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1381-1553 4.99e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.46  E-value: 4.99e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1381 RIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCNT 1460
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1461 iGVVIDGYPVTPHQMDLLE---ARSIIPMVIFELHVPSKEIFKRLL---LEKKTEQSMSYPLHNSSQIIAYKNA------ 1528
Cdd:cd01428    79 -GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERILgrrICPVSGRVYHLGKDDVTGEPLSQRSddneet 157

                         170       180       190
                  ....*....|....*....|....*....|.
gi 568966007 1529 ------KYHKNINEIRQFYQKQhQNWHVIDG 1553
Cdd:cd01428   158 ikkrleVYKEQTAPLIDYYKKK-GKLVEIDG 187
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 962-1177 7.51e-22

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 95.00  E-value: 7.51e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  962 RICLLGPHGSGKTVCARKLAENFGIFHIQFDEFLQEKMLLKaerkfgpefeddseeeqlvkqeleelaaqanvkieedtt 1041
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASG--------------------------------------- 41

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1042 kkqlpdvqlTEEEEAIKLSLTDNEPLPSEILDSILSEWwLKEPIRSTGFILDGFPRHPEEAQFLGE---RGFFPDAAVII 1118
Cdd:cd01428    42 ---------TELGKKAKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALDElldEGIKPDKVIEL 111

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1119 QVDDQDIFDRLLPAQVQKWKTKQHKKLERKKLIKDLKTKIKEDM-VAKRRAELILEREKK 1177
Cdd:cd01428   112 DVPDEVLIERILGRRICPVSGRVYHLGKDDVTGEPLSQRSDDNEeTIKKRLEVYKEQTAP 171
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1381-1503 3.71e-18

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 84.98  E-value: 3.71e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  1381 RIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCNT 1460
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKA--GTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNE 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 568966007  1461 IGVVIDGYPVTPHQMDLLEARSIIPM-VIFELHVPSKEIFKRLL 1503
Cdd:TIGR01351   79 NGFILDGFPRTLSQAEALDALLEEPIdAVIELDVPDEELVERLS 122
AAA_17 pfam13207
AAA domain;
1385-1506 5.84e-17

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 79.21  E-value: 5.84e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  1385 VGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNnhpDSELSLMLNwHLHKGKTVPDELAIQALDISLMESVCNTiGVV 1464
Cdd:pfam13207    1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAK---ERGLVEDRD-EMRKLPLEPQKELQKLAAERIAEEAGEG-GVI 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 568966007  1465 IDGYPVTPHQMDLLEA------RSIIPMVIFELHVPSKEIFKRLLLEK 1506
Cdd:pfam13207   76 VDGHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKDR 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 34-277 9.59e-17

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 80.36  E-value: 9.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   34 FIIFGKPGAGKTTLARNIAQAWKCIRVEALSVLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSPEVAHfGY 113
Cdd:cd01428     2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK-GF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  114 ILTEMP-SLAQdnmtsLKQIELVKNLELQPDIIINIKCSDYDLCQRTCGQRQHSTTGYVYTREQWDPEIIEsrrrkkrdf 192
Cdd:cd01428    81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHLGKDDVTGEP--------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  193 pkegkseeeeeeeeqeeeeafiaemqmvaeilqhLVQRPEDYLENVEITVKLYKELLLSALEEVMaehNPQYLIELDGNK 272
Cdd:cd01428   147 ----------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                  ....*
gi 568966007  273 SPEEL 277
Cdd:cd01428   190 DIDEV 194
adk PRK00279
adenylate kinase; Reviewed
 1381-1503 2.30e-16

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 79.81  E-value: 2.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1381 RIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCNT 1460
Cdd:PRK00279    2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKA--GTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKN 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568966007 1461 iGVVIDGYPVTPHQMDLLEA----RSI-IPMVIfELHVPSKEIFKRLL 1503
Cdd:PRK00279   80 -GFLLDGFPRTIPQAEALDEmlkeLGIkLDAVI-EIDVPDEELVERLS 125
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1381-1503 3.05e-16

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 79.40  E-value: 3.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1381 RIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSEL-----SLMlnwhlHKGKTVPDELAIQALDISLME 1455
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKA--GTELgkkakEYM-----DAGELVPDEIVIGLVKERLAQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568966007 1456 SVCNTiGVVIDGYPVTPHQMD----LLEARSIIPMVIFELHVPSKEIFKRLL 1503
Cdd:COG0563    75 PDCAN-GFILDGFPRTVAQAEaldeLLAELGIKLDAVIELDVDDEELVERLS 125
PLN02842 PLN02842
nucleotide kinase
 35-278 9.43e-14

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 76.05  E-value: 9.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   35 IIFGKPGAGKTTLARNIAQAWKCIRVEALSVLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSPEVAHFGYI 114
Cdd:PLN02842    1 MISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  115 LTEMPSlaqdnmtSLKQIELVKNLELQPDIIINIKCSDYDLCQRTCGQRQHSTTGYVYtreqwdpeiiesrrrKKRDFPK 194
Cdd:PLN02842   81 LDGYPR-------SFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIY---------------HIKNFPP 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  195 EGKseeeeeeeeqeeeeafiaemqmvaEILQHLVQRPEDYLENVEITVKLYK---ELLLSALEEVMaehnpqylIELDGN 271
Cdd:PLN02842  139 ESE------------------------EIKARLITRPDDTEEKVKARLQIYKknaEAILSTYSDIM--------VKIDGN 186


                  ....*..
gi 568966007  272 KSPEELF 278
Cdd:PLN02842  187 RPKEVVF 193
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 1382-1546 1.74e-13

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 71.00  E-value: 1.74e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  1382 IMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCNTI 1461
Cdd:TIGR01360    6 IFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVAS--GSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALGTSK 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  1462 GVVIDGYPVTPHQMDLLEARSIIPMVIFELHVPSKEIFKRLLLEKKTeqsmSYPLHNSSQIIAYKNAKYHKNINEIRQFY 1541
Cdd:TIGR01360   84 GFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAET----SGRVDDNEKTIKKRLETYYKATEPVIAYY 159


                   ....*
gi 568966007  1542 QKQHQ 1546
Cdd:TIGR01360  160 ETKGK 164
ADK pfam00406
Adenylate kinase;
1384-1503 2.15e-13

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 70.42  E-value: 2.15e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  1384 IVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCNTiGV 1463
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKS--GTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKN-GF 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 568966007  1464 VIDGYPVTPHQMDLLEA--RSIIPM-VIFELHVPSKEIFKRLL 1503
Cdd:pfam00406   78 LLDGFPRTVPQAEALEEllERGIKLdYVIEFDVPDEVLVERLT 120
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 34-172 4.53e-13

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 70.16  E-value: 4.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   34 FIIFGKPGAGKTTLARNIAQAWKcirVEALS---VLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSPEVAH 110
Cdd:COG0563     3 IILLGPPGAGKGTQAKRLAEKYG---IPHIStgdMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCAN 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568966007  111 fGYILTEMP-SLAQdnMTSLKqiELVKNLELQPDIIINIKCSDYDLCQRTCGQRQHSTTGYVY 172
Cdd:COG0563    80 -GFILDGFPrTVAQ--AEALD--ELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATY 137
ADK pfam00406
Adenylate kinase;
36-172 5.33e-13

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 69.26  E-value: 5.33e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007    36 IFGKPGAGKTTLARNIAQAWKCIRVEALSVLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSPEVAHfGYIL 115
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKN-GFLL 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568966007   116 TEMP-SLAQDNmtSLKQIELvknLELQPDIIINIKCSDYDLCQRTCGQRQHSTTGYVY 172
Cdd:pfam00406   80 DGFPrTVPQAE--ALEELLE---RGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSY 132
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 962-1130 2.40e-11

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 65.15  E-value: 2.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  962 RICLLGPHGSGKTVCARKLAENFGIFHIQF-DeflqekmLLKAERKfgpefeDDSEEEQLVKQELE--ELaaqanvkiee 1038
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTgD-------MLRAAVK------AGTELGKKAKEYMDagEL---------- 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1039 dttkkqLPDvqlteeeeaiklsltdneplpsEILDSILsEWWLKEPIRSTGFILDGFPRHPEEAQFL----GERGFFPDA 1114
Cdd:COG0563    59 ------VPD----------------------EIVIGLV-KERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDA 109

                         170
                  ....*....|....*.
gi 568966007 1115 AVIIQVDDQDIFDRLL 1130
Cdd:COG0563   110 VIELDVDDEELVERLS 125
adk PRK00279
adenylate kinase; Reviewed
 34-172 4.60e-11

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 64.40  E-value: 4.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   34 FIIFGKPGAGKTTLARNIAQAwkcIRVEALS---VLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSPEVAH 110
Cdd:PRK00279    3 LILLGPPGAGKGTQAKFIAEK---YGIPHIStgdMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKN 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568966007  111 fGYILTEMP-SLAQdnMTSLKqiELVKNLELQPDIIINIKCSDYDLCQRTCGQRQHSTTGYVY 172
Cdd:PRK00279   80 -GFLLDGFPrTIPQ--AEALD--EMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTY 137
PRK14527 PRK14527
adenylate kinase; Provisional
 1377-1503 7.36e-11

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 63.27  E-value: 7.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1377 TMPVRIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSELSLMLNWHLHKGKTVPDELAIQAL--DISLM 1454
Cdd:PRK14527    4 TKNKVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVAR--GTELGQRAKPIMEAGDLVPDELILALIrdELAGM 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568966007 1455 ESVcntiGVVIDGYPVTPHQMD----LLEARSIIPMVIFELHVPSKEIFKRLL 1503
Cdd:PRK14527   82 EPV----RVIFDGFPRTLAQAEaldrLLEELGARLLAVVLLEVPDEELIRRIV 130
PRK14530 PRK14530
adenylate kinase; Provisional
 1381-1502 1.70e-10

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 62.88  E-value: 1.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1381 RIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRG---MLNNHPDSELSLMLNWhLHKGKTVPDELAIQALDislmESV 1457
Cdd:PRK14530    5 RILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRAnkqMDISDMDTEYDTPGEY-MDAGELVPDAVVNEIVE----EAL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 568966007 1458 CNTIGVVIDGYPVTPHQMDLLEARSIIPMVIFeLHVPSKEIFKRL 1502
Cdd:PRK14530   80 SDADGFVLDGYPRNLEQAEYLESITDLDVVLY-LDVSEEELVDRL 123
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 28-163 1.04e-09

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 60.58  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   28 LSKPTCFIIFGKPGAGKTTLARNIAQAWKCIRVEALSVLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSPE 107
Cdd:PTZ00088    3 LKGPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVT 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568966007  108 VAHF-GYILTEMPSlaqdNMTSLKQIELVKNlelqPDIIINIKCSDYDLCQRTCGQR 163
Cdd:PTZ00088   83 DDCFkGFILDGFPR----NLKQCKELGKITN----IDLFVNIYLPRNILIKKLLGRR 131
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 962-1130 1.73e-09

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 59.56  E-value: 1.73e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   962 RICLLGPHGSGKTVCARKLAENFGIFHIQFDEFLQEKMllKAERKFGPEFEDDSEEEQLVkqeleelaaqanvkieedtt 1041
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEI--KAGTPLGKKAKEYMEKGELV-------------------- 58

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  1042 kkqlpdvqlteeeeaiklsltdneplPSEILDSILSEWWLKEPIRSTGFILDGFPRHPEEAQFLGERGFFP-DAAVIIQV 1120
Cdd:TIGR01351   59 --------------------------PDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALDALLEEPiDAVIELDV 112

                          170
                   ....*....|
gi 568966007  1121 DDQDIFDRLL 1130
Cdd:TIGR01351  113 PDEELVERLS 122
AAA_17 pfam13207
AAA domain;
966-1130 2.16e-08

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 54.55  E-value: 2.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   966 LGPHGSGKTVCARKLAENFGIFHIQF-DEFLQEkmllkAERKFGPEFEDDSEEEQLVKQEleELAAQANVKIEEDTTKKq 1044
Cdd:pfam13207    1 TGVPGSGKTTQLKKLAEKLGFPHISAgDLLREE-----AKERGLVEDRDEMRKLPLEPQK--ELQKLAAERIAEEAGEG- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  1045 lpdvqlteeeeaiklsltdneplpseildsilsewwlkepirstGFILDGFPRHPEEAQFLGE------RGFFPDAAVII 1118
Cdd:pfam13207   73 --------------------------------------------GVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILL 108

                          170
                   ....*....|..
gi 568966007  1119 QVDDQDIFDRLL 1130
Cdd:pfam13207  109 EADPEEILERRL 120
PRK14531 PRK14531
adenylate kinase; Provisional
 1378-1503 2.77e-08

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 55.59  E-value: 2.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1378 MPVRIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNnhPDSELSLMLNWHLHKGKTVPDELAIqALDISLMESV 1457
Cdd:PRK14531    1 MKQRLLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVA--AGSALGQEAEAVMNRGELVSDALVL-AIVESQLKAL 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568966007 1458 cNTIGVVIDGYPVTPHQMDLLEA------RSIIPMVIFELHvpSKEIFKRLL 1503
Cdd:PRK14531   78 -NSGGWLLDGFPRTVAQAEALEPlleelkQPIEAVVLLELD--DAVLIERLL 126
PRK14532 PRK14532
adenylate kinase; Provisional
 1382-1502 4.30e-08

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 55.21  E-value: 4.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1382 IMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCNTi 1461
Cdd:PRK14532    3 LILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIAS--GSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEAAG- 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 568966007 1462 GVVIDGYPVTPHQMD----LLEARSIIPMVIFELHVPSKEIFKRL 1502
Cdd:PRK14532   80 GAIFDGFPRTVAQAEaldkMLASRGQKIDVVIRLKVDDEALIERI 124
ADK pfam00406
Adenylate kinase;
965-1130 7.93e-08

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 54.24  E-value: 7.93e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   965 LLGPHGSGKTVCARKLAENFGIFHIQFDEFLQEKMllKAERKFGPEFEDDSEEEQLVkqeleelaaqanvkieedttkkq 1044
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEI--KSGTELGKEAKEYMDKGELV----------------------- 55

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  1045 lpdvqlteeeeaiklsltdneplPSEILDSILSEWwLKEPIRSTGFILDGFPRHPEEAQFL---GERGFFPDAAVIIQVD 1121
Cdd:pfam00406   56 -----------------------PDEVVVGLVKER-LEQNDCKNGFLLDGFPRTVPQAEALeelLERGIKLDYVIEFDVP 111


                   ....*....
gi 568966007  1122 DQDIFDRLL 1130
Cdd:pfam00406  112 DEVLVERLT 120
PLN02842 PLN02842
nucleotide kinase
 1383-1588 8.50e-08

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 57.18  E-value: 8.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1383 MIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSELSLMLNWHLHKGKTVPDELAIQALDISL-MESVCNTi 1461
Cdd:PLN02842    1 MISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSA--GTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLsREDAKEK- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1462 GVVIDGYPVTPHQMDLLEARSIIPMVIFELHVPSKEIFKRLL------LEKKTEQSMSYPLHN---SSQIIAY-----KN 1527
Cdd:PLN02842   78 GWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVgrrldpVTGKIYHIKNFPPESeeiKARLITRpddteEK 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568966007 1528 AK-----YHKNINEIRQFYQKQHQNwhvIDGFHSKwwvwNEVLKDIQQ-MNKYIQTYMKKIKEGKAA 1588
Cdd:PLN02842  158 VKarlqiYKKNAEAILSTYSDIMVK---IDGNRPK----EVVFEEISSlLSQIQKDATKMIKTKKAS 217
adk PRK02496
adenylate kinase; Provisional
 1381-1553 1.14e-07

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 53.60  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1381 RIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNHpdSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCNT 1460
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQ--TPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAAN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1461 iGVVIDGYPVTPHQMDLLEA----------RSIipmvifELHVPSKEIFKRLLLEKKTEqsmsyplhNSSQIIAYKNAKY 1530
Cdd:PRK02496   81 -GWILDGFPRKVTQAAFLDEllqeigqsgeRVV------NLDVPDDVVVERLLARGRKD--------DTEEVIRRRLEVY 145

                         170       180
                  ....*....|....*....|...
gi 568966007 1531 HKNINEIRQFYQKQHQNWHvIDG 1553
Cdd:PRK02496  146 REQTAPLIDYYRDRQKLLT-IDG 167
adk PRK02496
adenylate kinase; Provisional
 35-158 1.44e-07

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 53.60  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   35 IIFGKPGAGKTTLARNIAQAWKCIRVEALSVLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSPEVAHfGYI 114
Cdd:PRK02496    5 IFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAAN-GWI 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 568966007  115 LTEMP-SLAQDNMTSlkqiELVKNLELQPDIIINIKCSDYDLCQR 158
Cdd:PRK02496   84 LDGFPrKVTQAAFLD----ELLQEIGQSGERVVNLDVPDDVVVER 124
PRK04182 PRK04182
cytidylate kinase; Provisional
 1380-1417 2.08e-07

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 52.89  E-value: 2.08e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568966007 1380 VRIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGM 1417
Cdd:PRK04182    1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFREL 38
adk PRK00279
adenylate kinase; Reviewed
 961-1130 2.28e-07

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 53.62  E-value: 2.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  961 LRICLLGPHGSGKTVCARKLAENFGIFHIQF-DeflqekmLLKAErkfgpefeddseeeqlVKQElEELAaqanVKIEED 1039
Cdd:PRK00279    1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTgD-------MLRAA----------------VKAG-TELG----KEAKSY 52

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1040 TTKKQLpdvqlteeeeaiklsltdnepLPSEILDSILSEWwLKEPIRSTGFILDGFPRHPEEAQ----FLGERGFFPDAA 1115
Cdd:PRK00279   53 MDAGEL---------------------VPDEIVIGLVKER-LAQPDCKNGFLLDGFPRTIPQAEaldeMLKELGIKLDAV 110

                         170
                  ....*....|....*
gi 568966007 1116 VIIQVDDQDIFDRLL 1130
Cdd:PRK00279  111 IEIDVPDEELVERLS 125
adk PRK02496
adenylate kinase; Provisional
 962-1130 4.20e-07

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 52.06  E-value: 4.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  962 RICLLGPHGSGKTVCARKLAENFGIFHIQFDEFLQEKMllkaerkfgpefeddseeeqlvkQELEELAAQANVKIEEdtt 1041
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAI-----------------------KEQTPLGIKAQGYMDK--- 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1042 kkqlpdvqlteeeeaiklsltdNEPLPSEILDSILSEWwLKEPIRSTGFILDGFPRHPEEAQFL-------GERGffpDA 1114
Cdd:PRK02496   57 ----------------------GELVPDQLVLDLVQER-LQQPDAANGWILDGFPRKVTQAAFLdellqeiGQSG---ER 110

                         170
                  ....*....|....*.
gi 568966007 1115 AVIIQVDDQDIFDRLL 1130
Cdd:PRK02496  111 VVNLDVPDDVVVERLL 126
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 899-954 6.72e-07

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 47.78  E-value: 6.72e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568966007  899 GDTKHFCPVVlkeNFVLQPGNPDEAVKYREKIYYFSSTEAKEKFLEHPEDYVSQNE 954
Cdd:COG3350     3 GVAMVIDPVC---GMTVDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
PRK14527 PRK14527
adenylate kinase; Provisional
 29-103 8.68e-07

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 51.33  E-value: 8.68e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568966007   29 SKPTCFIIFGKPGAGKTTLARNIAQAWKCIRVEALSVLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKI 103
Cdd:PRK14527    4 TKNKVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDEL 78
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 1382-1503 1.16e-06

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 50.83  E-value: 1.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  1382 IMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNHpDSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCNTi 1461
Cdd:TIGR01359    2 VFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKRE-GSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSSK- 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 568966007  1462 GVVIDGYPVTPHQMDLLEA---RSIIPMVIFELHVPSKEIFKRLL 1503
Cdd:TIGR01359   80 KFLIDGFPRNEENLEAWEKlmdNKVNFKFVLFFDCPEETMIKRLL 124
PRK14528 PRK14528
adenylate kinase; Provisional
 35-162 1.67e-06

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 50.40  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   35 IIFGKPGAGKTTLARNIAQAWKCIRVEALSVLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSPEVAHfGYI 114
Cdd:PRK14528    5 IFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKN-GFL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 568966007  115 LTEMP-SLAQDNMTSlkqiELVKNLELQPDIIINIKCSDYDLCQRTCGQ 162
Cdd:PRK14528   84 LDGFPrTVEQADALD----ALLKNEGKSIDKAINLEVPDGELLKRLLGR 128
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 1380-1417 1.75e-06

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 50.11  E-value: 1.75e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568966007  1380 VRIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGM 1417
Cdd:TIGR02173    1 MIITISGPPGSGKTTVAKILAEKLSLKLISAGDIFREL 38
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 1375-1503 2.01e-06

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 50.95  E-value: 2.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1375 KATMPVRIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSELSLMLNWHLHKGKTVPDELAIQALDISLM 1454
Cdd:PTZ00088    2 KLKGPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKA--KTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 568966007 1455 ESV-CNTIGVVIDGYPVTPHQMDLLEARSIIPMVIfELHVPSKEIFKRLL 1503
Cdd:PTZ00088   80 KVTdDCFKGFILDGFPRNLKQCKELGKITNIDLFV-NIYLPRNILIKKLL 128
PRK13808 PRK13808
adenylate kinase; Provisional
 35-141 2.14e-06

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 51.81  E-value: 2.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   35 IIFGKPGAGKTTLARNIAQAWKCIRVEALSVLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSPEVAHfGYI 114
Cdd:PRK13808    4 ILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAAN-GFI 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 568966007  115 LTEMP-----SLAQDNMTSLKQIELVKNLELQ 141
Cdd:PRK13808   83 LDGFPrtvpqAEALDALLKDKQLKLDAVVELR 114
PRK14532 PRK14532
adenylate kinase; Provisional
 35-158 3.02e-06

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 49.82  E-value: 3.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   35 IIFGKPGAGKTTLARNIAQAWKCIRVEALSVLEEHIAAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSPEVAHfGYI 114
Cdd:PRK14532    4 ILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEAAG-GAI 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 568966007  115 LTEMP-SLAQdnMTSLKQieLVKNLELQPDIIINIKCSDYDLCQR 158
Cdd:PRK14532   83 FDGFPrTVAQ--AEALDK--MLASRGQKIDVVIRLKVDDEALIER 123
PLN02459 PLN02459
probable adenylate kinase
 1386-1488 4.34e-06

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 50.23  E-value: 4.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1386 GPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCN-TIGVV 1464
Cdd:PLN02459   36 GCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKS--SGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEEgESGFI 113

                          90       100
                  ....*....|....*....|....
gi 568966007 1465 IDGYPVTPHQMDLLEARSIIPMVI 1488
Cdd:PLN02459  114 LDGFPRTVRQAEILEGVTDIDLVV 137
PLN02674 PLN02674
adenylate kinase
 1381-1479 8.30e-06

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 49.11  E-value: 8.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1381 RIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNnhPDSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCNT 1460
Cdd:PLN02674   33 RLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVA--AKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKPSCQK 110

                          90
                  ....*....|....*....
gi 568966007 1461 iGVVIDGYPVTPHQMDLLE 1479
Cdd:PLN02674  111 -GFILDGFPRTVVQAQKLD 128
AAA_18 pfam13238
AAA domain;
1382-1509 2.64e-05

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 45.50  E-value: 2.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  1382 IMIVGPPKSGKTTVAKKLAsdyglRCLSVGDALRgmlNNHPDSELSLMLNWHLHKGKTVPDELAIQALDIsLMESVCNTI 1461
Cdd:pfam13238    1 ILITGTPGVGKTTLAKELS-----KRLGFGDNVR---DLALENGLVLGDDPETRESKRLDEDKLDRLLDL-LEENAALEE 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 568966007  1462 G--VVIDGypvtphQMDLLEARSIIPMVIFELHVPSKEIFKRLLLEKKTE 1509
Cdd:pfam13238   72 GgnLIIDG------HLAELEPERAKDLVGIVLRASPEELLERLEKRGYEE 115
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 1381-1412 3.00e-05

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 45.94  E-value: 3.00e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568966007 1381 RIMIVGPPKSGKTTVAKKLASDYGLRCLSVGD 1412
Cdd:cd02020     1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTGG 32
AAA_17 pfam13207
AAA domain;
37-158 3.63e-05

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 45.31  E-value: 3.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007    37 FGKPGAGKTTLARNIAQAWKCIRVEALSVLEEHiaAEKETGAMLQSLLVSGHSIPDELVTKLILEKIKSpEVAHFGYILT 116
Cdd:pfam13207    1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREE--AKERGLVEDRDEMRKLPLEPQKELQKLAAERIAE-EAGEGGVIVD 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 568966007   117 EMPSLaQDNMTSLKQIELVKNLELQPDIIINIKCSDYDLCQR 158
Cdd:pfam13207   78 GHPRI-KTPAGYLPGLPVEVLRELKPDAIILLEADPEEILER 118
PLN02200 PLN02200
adenylate kinase family protein
 14-164 3.64e-05

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 47.19  E-value: 3.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   14 TDIFNEDETDRNCLLSKPTCFIIFGKPGAGKTTLARNIAQAWKCIRVEALSVLEEHIAAEKETGAMLQSLLVSGHSIPDE 93
Cdd:PLN02200   26 TEIITLEERGSSSKEKTPFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSE 105

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568966007   94 LVTKLILEKIKSPEVAHF---GYILTEmpslaqDNMTSLKQIelvknLELQPDIIINIKCSDYDLCQRTCGQRQ 164
Cdd:PLN02200  106 VTVKLIQKEMESSDNNKFlidGFPRTE------ENRIAFERI-----IGAEPNVVLFFDCPEEEMVKRVLNRNQ 168
PRK13808 PRK13808
adenylate kinase; Provisional
 1381-1480 1.45e-04

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 46.03  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1381 RIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNnhPDSELSLMLNWHLHKGKTVPDELAIQALDISLmESVCNT 1460
Cdd:PRK13808    2 RLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVA--AGTPVGLKAKDIMASGGLVPDEVVVGIISDRI-EQPDAA 78

                          90       100
                  ....*....|....*....|
gi 568966007 1461 IGVVIDGYPVTPHQMDLLEA 1480
Cdd:PRK13808   79 NGFILDGFPRTVPQAEALDA 98
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
967-1032 1.95e-04

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 43.75  E-value: 1.95e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568966007  967 GPHGSGKTVCARKLAENFGIFHIQFDEFlqEKMLLKAERkfgPEFEDDSEEEQLVKQELEELAAQA 1032
Cdd:COG0645     6 GLPGSGKSTLARALAERLGAVRLRSDVV--RKRLFGAGL---APLERSPEATARTYARLLALAREL 66
COG4639 COG4639
Predicted kinase [General function prediction only];
1378-1501 4.68e-04

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 42.51  E-value: 4.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1378 MPVRIMIVGPPKSGKTTVAKKLASDYGLrcLSVgDALRGMLNNHP-DSELSLMLNWHLHkgktvpdELAIQALDISLmes 1456
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFARRLFAPTEV--VSS-DDIRALLGGDEnDQSAWGDVFQLAH-------EIARARLRAGR--- 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568966007 1457 vcntiGVVIDGYPVTPHQ-MDLLE-ARSI-IPMVIFELHVPSKEIFKR 1501
Cdd:COG4639    68 -----LTVVDATNLQREArRRLLAlARAYgALVVAVVLDVPLEVCLAR 110
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 904-950 1.17e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 43.02  E-value: 1.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 568966007   904 FCPVVL-KENFVLQPGNPDEAV-KYREKIYYFSSTEAKEKFLEHPEDYV 950
Cdd:pfam12018  201 FCAWTLvVRDGLLLPGNPSIGVlKYKDKYYAFSSKEAAYEFASDPDRFI 249
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
34-60 1.44e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 41.44  E-value: 1.44e-03
                          10        20
                  ....*....|....*....|....*..
gi 568966007   34 FIIFGKPGAGKTTLARNIAQAWKCIRV 60
Cdd:COG0645     2 ILVCGLPGSGKSTLARALAERLGAVRL 28
PRK14526 PRK14526
adenylate kinase; Provisional
 1380-1479 1.81e-03

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 41.76  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007 1380 VRIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALRGMLNNhpDSELSLMLNWHLHKGKTVPDELAIQALDiSLMESVCN 1459
Cdd:PRK14526    1 MKLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILN--STPLGKEIKQIVENGQLVPDSITIKIVE-DKINTIKN 77

                          90       100
                  ....*....|....*....|
gi 568966007 1460 TIGVVIDGYPVTPHQMDLLE 1479
Cdd:PRK14526   78 NDNFILDGFPRNINQAKALD 97
AAA_28 pfam13521
AAA domain;
962-1033 2.03e-03

AAA domain;


Pssm-ID: 433278 [Multi-domain]  Cd Length: 164  Bit Score: 40.71  E-value: 2.03e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568966007   962 RICLLGPHGSGKTVCARKLAENFGIFHIQ--FDEFLQEKMllKAERKFGPEFEDDSE-EEQLVKQELEELAAQAN 1033
Cdd:pfam13521    1 RIVITGGPSTGKTTLAEALAARFGYPVVPeaAREILEELG--ADGGDALPWVEDLLAfARGVLEAQLEDEAAAAA 73
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
1381-1415 2.79e-03

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 40.57  E-value: 2.79e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568966007 1381 RIMIVGPPKSGKTTVAKKLASDYGLRCLSVGDALR 1415
Cdd:COG1936     2 RIAITGTPGTGKTTVAKLLAERLGLEVIHLNDLVK 36
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 34-64 3.31e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 41.99  E-value: 3.31e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 568966007   34 FIIFGKPGAGKTTLARNIAQAWKCiRVEALS 64
Cdd:PRK13342   39 MILWGPPGTGKTTLARIIAGATDA-PFEALS 68
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 1382-1502 3.70e-03

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 39.60  E-value: 3.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  1382 IMIVGPPKSGKTTVAKKLASDYGLRCLSVgDALRGMLNNHPDSELSLMLNW------HLHkgktvpdELAIQALdislme 1455
Cdd:pfam13671    2 ILLVGLPGSGKSTLARRLLEELGAVRLSS-DDERKRLFGEGRPSISYYTDAtdrtyeRLH-------ELARIAL------ 67

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568966007  1456 svcnTIG--VVIDGYPVTPHQMDLLE--ARSI-IPMVIFELHVPSKEIFKRL 1502
Cdd:pfam13671   68 ----RAGrpVILDATNLRRDERARLLalAREYgVPVRIVVFEAPEEVLRERL 115
PRK14530 PRK14530
adenylate kinase; Provisional
 35-278 3.96e-03

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 40.93  E-value: 3.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   35 IIFGKPGAGKTTLARNIAQAWKCIRV---EALSVLEEHIAAEKET-----GAMLQsllvSGHSIPDELVTKLILEKIKSP 106
Cdd:PRK14530    7 LLLGAPGAGKGTQSSNLAEEFGVEHVttgDALRANKQMDISDMDTeydtpGEYMD----AGELVPDAVVNEIVEEALSDA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  107 EvahfGYILTEMPSlaqdNMTSLKQIELVKNLelqpDIIINIKCSDYDLCQRTCGQRQHSTTGYVYTREQWDPEiiesrr 186
Cdd:PRK14530   83 D----GFVLDGYPR----NLEQAEYLESITDL----DVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPE------ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007  187 rkkrdfpkegkseeeeeeeeqeeeeafiaEMQMVAEILQHLVQRPEDYLENVEITVKLYKElllsALEEVMAEHNPQ-YL 265
Cdd:PRK14530  145 -----------------------------EEGVCDECGGELIQRDDDTEETVRERLDVFEE----NTEPVIEHYRDQgVL 191

                         250
                  ....*....|...
gi 568966007  266 IELDGNKSPEELF 278
Cdd:PRK14530  192 VEVDGEQTPDEVW 204
NadR3 COG3172
Nicotinamide riboside kinase [Coenzyme transport and metabolism]; Nicotinamide riboside kinase ...
 1372-1415 4.03e-03

Nicotinamide riboside kinase [Coenzyme transport and metabolism]; Nicotinamide riboside kinase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 442405 [Multi-domain]  Cd Length: 178  Bit Score: 40.19  E-value: 4.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568966007 1372 PKPKATMPVRIMIVGPPKSGKTTVAKKLASDYGlrCLSVGDALR 1415
Cdd:COG3172     1 PEVRPSFVKKIVLLGAESTGKTTLARALAAHYN--TPWVPEYGR 42
AAA_28 pfam13521
AAA domain;
1381-1449 4.32e-03

AAA domain;


Pssm-ID: 433278 [Multi-domain]  Cd Length: 164  Bit Score: 39.94  E-value: 4.32e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568966007  1381 RIMIVGPPKSGKTTVAKKLASDYGLRClsVGDALRGMLNNHPDSElSLMLNWhlhkgktVPDELAIQAL 1449
Cdd:pfam13521    1 RIVITGGPSTGKTTLAEALAARFGYPV--VPEAAREILEELGADG-GDALPW-------VEDLLAFARG 59
rho_factor_C cd01128
C-terminal ATP binding domain of transcription termination factor rho; Transcription ...
 1381-1430 4.58e-03

C-terminal ATP binding domain of transcription termination factor rho; Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal oligonucleotide/oligosaccharide binding fold (OB-fold) domain which binds cysteine-rich nucleotides, and a C-terminal ATP binding domain. This alignment is of the C-terminal ATP binding domain.


Pssm-ID: 410872 [Multi-domain]  Cd Length: 249  Bit Score: 41.04  E-value: 4.58e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568966007 1381 RIMIVGPPKSGKTTVAKKLAsdyglrclsvgdalRGMLNNHPDSELSLML 1430
Cdd:cd01128    18 RGLIVAPPKAGKTTLLQNIA--------------NAIAKNHPEVELIVLL 53
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 1382-1466 4.95e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 39.66  E-value: 4.95e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966007   1382 IMIVGPPKSGKTTVAKKLASDYGLRCLSVgdaLRGMLNNHPDSELSLMLNWHLHKGKTVPDELAIQALDISLMESVCNTI 1461
Cdd:smart00382    5 ILIVGPPGSGKTTLARALARELGPPGGGV---IYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDV 81


                    ....*
gi 568966007   1462 gVVID 1466
Cdd:smart00382   82 -LILD 85
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
1382-1418 5.27e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 39.51  E-value: 5.27e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568966007 1382 IMIVGPPKSGKTTVAKKLASDYGLRCLSVgDALRGML 1418
Cdd:COG0645     2 ILVCGLPGSGKSTLARALAERLGAVRLRS-DVVRKRL 37
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
 1382-1419 5.40e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 39.40  E-value: 5.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568966007 1382 IMIVGPPKSGKTTVAKKLASDYGLRCLSVGDAL-RGMLN 1419
Cdd:NF033453   19 ILLVGPPGSGKTALLRELAAKRGAPVINVNLELsRRLLE 57
PRK14528 PRK14528
adenylate kinase; Provisional
 1081-1130 7.51e-03

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 39.61  E-value: 7.51e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568966007 1081 LKEPIRSTGFILDGFPRHPEEA----QFLGERGFFPDAAVIIQVDDQDIFDRLL 1130
Cdd:PRK14528   73 IREADCKNGFLLDGFPRTVEQAdaldALLKNEGKSIDKAINLEVPDGELLKRLL 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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