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Conserved domains on  [gi|569000781|ref|XP_006524575|]
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rho guanine nucleotide exchange factor 33 isoform X3 [Mus musculus]

Protein Classification

RhoGEF domain-containing protein( domain architecture ID 4023)

RhoGEF domain-containing protein contains guanine nucleotide exchange factor (GEF) activity to regulate small GTPases in the Rho family

CATH:  1.20.900.10
Gene Ontology:  GO:0005085

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RhoGEF super family cl47571
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
259-426 9.61e-15

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


The actual alignment was detected with superfamily member pfam00621:

Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 73.10  E-value: 9.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000781  259 VALELLESERKYVINISLILKIKATFQGSDGKRNPKE-RSLFpGSLRYLVQQHLDLLhaLQERVLKWPRQGVLGDLFLKL 337
Cdd:pfam00621   1 VIKELLQTERSYVRDLEILVEVFLPPNSKPLSESEEEiKTIF-SNIEEIYELHRQLL--LEELLKEWISIQRIGDIFLKF 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000781  338 TNdennFLDYYVAYLRDLPECISLVHvvvlkegDEEIKSDIYTLFFHI-------------------VQRIPEYLIHLQN 398
Cdd:pfam00621  78 AP----GFKVYSTYCSNYPKALKLLK-------KLLKKNPKFRAFLEEleanpecrgldlnsflikpVQRIPRYPLLLKE 146
                         170       180
                  ....*....|....*....|....*...
gi 569000781  399 VLKFTEQEHPDYYLLLVCVQRLRVFISH 426
Cdd:pfam00621 147 LLKHTPPDHPDYEDLKKALEAIKEVAKQ 174
ZapB super family cl43780
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
54-120 7.88e-03

Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG3074:

Pssm-ID: 442308 [Multi-domain]  Cd Length: 79  Bit Score: 36.10  E-value: 7.88e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569000781  54 LEEKVKScrcsMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKA 120
Cdd:COG3074    9 LEAKVQQ----AVDTIELLQMEVEELKEKNEELEQENEELQSENEELQSENEQLKTENAEWQERIRS 71
 
Name Accession Description Interval E-value
RhoGEF pfam00621
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
259-426 9.61e-15

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 73.10  E-value: 9.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000781  259 VALELLESERKYVINISLILKIKATFQGSDGKRNPKE-RSLFpGSLRYLVQQHLDLLhaLQERVLKWPRQGVLGDLFLKL 337
Cdd:pfam00621   1 VIKELLQTERSYVRDLEILVEVFLPPNSKPLSESEEEiKTIF-SNIEEIYELHRQLL--LEELLKEWISIQRIGDIFLKF 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000781  338 TNdennFLDYYVAYLRDLPECISLVHvvvlkegDEEIKSDIYTLFFHI-------------------VQRIPEYLIHLQN 398
Cdd:pfam00621  78 AP----GFKVYSTYCSNYPKALKLLK-------KLLKKNPKFRAFLEEleanpecrgldlnsflikpVQRIPRYPLLLKE 146
                         170       180
                  ....*....|....*....|....*...
gi 569000781  399 VLKFTEQEHPDYYLLLVCVQRLRVFISH 426
Cdd:pfam00621 147 LLKHTPPDHPDYEDLKKALEAIKEVAKQ 174
RhoGEF cd00160
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ...
256-426 1.29e-10

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 238091 [Multi-domain]  Cd Length: 181  Bit Score: 61.16  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000781 256 RQTVALELLESERKYVINISLILKIKATFQGSDGKRNPKE--RSLFpGSLRYLVQQHLDLLHALQERVLKWPRQGV-LGD 332
Cdd:cd00160    1 RQEVIKELLQTERNYVRDLKLLVEVFLKPLDKELLPLSPEevELLF-GNIEEIYEFHRIFLKSLEERVEEWDKSGPrIGD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000781 333 LFLKLtndeNNFLDYYVAYLRDLPECISL----------VHVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKF 402
Cdd:cd00160   80 VFLKL----APFFKIYSEYCSNHPDALELlkklkkfnkfFQEFLEKAESECGRLKLESLLLKPVQRLTKYPLLLKELLKH 155
                        170       180
                 ....*....|....*....|....
gi 569000781 403 TEQEHPDYYLLLVCVQRLRVFISH 426
Cdd:cd00160  156 TPDGHEDREDLKKALEAIKEVASQ 179
RhoGEF smart00325
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange ...
259-435 2.11e-10

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Improved coverage.


Pssm-ID: 214619 [Multi-domain]  Cd Length: 180  Bit Score: 60.78  E-value: 2.11e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000781   259 VALELLESERKYVINISLILKI-KATFQGSDGKRNPKE-RSLFpGSLRYLVQQHLDLLHALQERVLKWPRQGV-LGDLFL 335
Cdd:smart00325   1 VLKELLQTERNYVRDLKLLVEVfLKPLKKELKLLSPNElETLF-GNIEEIYEFHRDFLDELEERIEEWDDSVErIGDVFL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000781   336 KLtndeNNFLDYYVAYLRDLPECISLVH--------VVVLKEGDEEIKSDIYTLFFHI---VQRIPEYLIHLQNVLKFTE 404
Cdd:smart00325  80 KL----EEFFKIYSEYCSNHPDALELLKklkknprfQKFLKEIESSPQCRRLTLESLLlkpVQRLTKYPLLLKELLKHTP 155
                          170       180       190
                   ....*....|....*....|....*....|.
gi 569000781   405 QEHPDYYLLLVCVQRLRvfishyTLLFQCNE 435
Cdd:smart00325 156 EDHEDREDLKKALKAIK------ELANQVNE 180
ZapB COG3074
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
54-120 7.88e-03

Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442308 [Multi-domain]  Cd Length: 79  Bit Score: 36.10  E-value: 7.88e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569000781  54 LEEKVKScrcsMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKA 120
Cdd:COG3074    9 LEAKVQQ----AVDTIELLQMEVEELKEKNEELEQENEELQSENEELQSENEQLKTENAEWQERIRS 71
 
Name Accession Description Interval E-value
RhoGEF pfam00621
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
259-426 9.61e-15

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 73.10  E-value: 9.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000781  259 VALELLESERKYVINISLILKIKATFQGSDGKRNPKE-RSLFpGSLRYLVQQHLDLLhaLQERVLKWPRQGVLGDLFLKL 337
Cdd:pfam00621   1 VIKELLQTERSYVRDLEILVEVFLPPNSKPLSESEEEiKTIF-SNIEEIYELHRQLL--LEELLKEWISIQRIGDIFLKF 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000781  338 TNdennFLDYYVAYLRDLPECISLVHvvvlkegDEEIKSDIYTLFFHI-------------------VQRIPEYLIHLQN 398
Cdd:pfam00621  78 AP----GFKVYSTYCSNYPKALKLLK-------KLLKKNPKFRAFLEEleanpecrgldlnsflikpVQRIPRYPLLLKE 146
                         170       180
                  ....*....|....*....|....*...
gi 569000781  399 VLKFTEQEHPDYYLLLVCVQRLRVFISH 426
Cdd:pfam00621 147 LLKHTPPDHPDYEDLKKALEAIKEVAKQ 174
RhoGEF cd00160
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ...
256-426 1.29e-10

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 238091 [Multi-domain]  Cd Length: 181  Bit Score: 61.16  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000781 256 RQTVALELLESERKYVINISLILKIKATFQGSDGKRNPKE--RSLFpGSLRYLVQQHLDLLHALQERVLKWPRQGV-LGD 332
Cdd:cd00160    1 RQEVIKELLQTERNYVRDLKLLVEVFLKPLDKELLPLSPEevELLF-GNIEEIYEFHRIFLKSLEERVEEWDKSGPrIGD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000781 333 LFLKLtndeNNFLDYYVAYLRDLPECISL----------VHVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKF 402
Cdd:cd00160   80 VFLKL----APFFKIYSEYCSNHPDALELlkklkkfnkfFQEFLEKAESECGRLKLESLLLKPVQRLTKYPLLLKELLKH 155
                        170       180
                 ....*....|....*....|....
gi 569000781 403 TEQEHPDYYLLLVCVQRLRVFISH 426
Cdd:cd00160  156 TPDGHEDREDLKKALEAIKEVASQ 179
RhoGEF smart00325
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange ...
259-435 2.11e-10

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Improved coverage.


Pssm-ID: 214619 [Multi-domain]  Cd Length: 180  Bit Score: 60.78  E-value: 2.11e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000781   259 VALELLESERKYVINISLILKI-KATFQGSDGKRNPKE-RSLFpGSLRYLVQQHLDLLHALQERVLKWPRQGV-LGDLFL 335
Cdd:smart00325   1 VLKELLQTERNYVRDLKLLVEVfLKPLKKELKLLSPNElETLF-GNIEEIYEFHRDFLDELEERIEEWDDSVErIGDVFL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000781   336 KLtndeNNFLDYYVAYLRDLPECISLVH--------VVVLKEGDEEIKSDIYTLFFHI---VQRIPEYLIHLQNVLKFTE 404
Cdd:smart00325  80 KL----EEFFKIYSEYCSNHPDALELLKklkknprfQKFLKEIESSPQCRRLTLESLLlkpVQRLTKYPLLLKELLKHTP 155
                          170       180       190
                   ....*....|....*....|....*....|.
gi 569000781   405 QEHPDYYLLLVCVQRLRvfishyTLLFQCNE 435
Cdd:smart00325 156 EDHEDREDLKKALKAIK------ELANQVNE 180
ZapB COG3074
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
54-120 7.88e-03

Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442308 [Multi-domain]  Cd Length: 79  Bit Score: 36.10  E-value: 7.88e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569000781  54 LEEKVKScrcsMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKA 120
Cdd:COG3074    9 LEAKVQQ----AVDTIELLQMEVEELKEKNEELEQENEELQSENEELQSENEQLKTENAEWQERIRS 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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