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Conserved domains on  [gi|569009949|ref|XP_006528004|]
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testis-specific protein TSX isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF5404 super family cl38677
Family of unknown function (DUF5404); This is a family of unknown function found in Chordata. ...
 1-144 5.03e-80

Family of unknown function (DUF5404); This is a family of unknown function found in Chordata. This domain is located downstream the N-terminal of Fip1 pfam05182. Family members such as Swiss:P70537 and Swiss:P70675 contain this domain. The Tsx gene resides at the X-inactivation centre and once thought to encode a protein expressed in testis. However, this was disputed upon further analysis. ORF and immunostaining analysis concluded that Tsx may be non-coding. Tsx long transcript is abundantly expressed in meiotic germ cells, embryonic stem cells, and brain. In vertebrates, Fip1 is the evolutionary precursor of eutherian Tsx, hence its location upstream from the Tsx gene.


The actual alignment was detected with superfamily member pfam17397:

Pssm-ID: 340112  Cd Length: 145  Bit Score: 232.71  E-value: 5.03e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009949    1 MSEKQSPKTSEAECSAMDLPEFEDEENWLFKVLGFQPGPSSALDDDTDDQADEPLSAAEFLHLQDILQEDRVSSTDDEDT 80
Cdd:pfam17397   1 MSEEQEPKTSEAECGAMDFPEFEDEEEWLFKVLGFKPGPSSALDDDADDQADEPLGAAEFLHLQDILQEDKVSSTDDEDT 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569009949   81 CQAGCTED-DETSHSDRDIDNNVKVITGNIKASPSMYMEMFTDQNPQADQDLEETESDGAMNPTD 144
Cdd:pfam17397  81 CQAGCTEDnDEASHSDRDIDDNVKVIIGDIKANPSMYMEMFTDMNPQADQDLEETESDGAMNPTD 145
 
Name Accession Description Interval E-value
DUF5404 pfam17397
Family of unknown function (DUF5404); This is a family of unknown function found in Chordata. ...
 1-144 5.03e-80

Family of unknown function (DUF5404); This is a family of unknown function found in Chordata. This domain is located downstream the N-terminal of Fip1 pfam05182. Family members such as Swiss:P70537 and Swiss:P70675 contain this domain. The Tsx gene resides at the X-inactivation centre and once thought to encode a protein expressed in testis. However, this was disputed upon further analysis. ORF and immunostaining analysis concluded that Tsx may be non-coding. Tsx long transcript is abundantly expressed in meiotic germ cells, embryonic stem cells, and brain. In vertebrates, Fip1 is the evolutionary precursor of eutherian Tsx, hence its location upstream from the Tsx gene.


Pssm-ID: 340112  Cd Length: 145  Bit Score: 232.71  E-value: 5.03e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009949    1 MSEKQSPKTSEAECSAMDLPEFEDEENWLFKVLGFQPGPSSALDDDTDDQADEPLSAAEFLHLQDILQEDRVSSTDDEDT 80
Cdd:pfam17397   1 MSEEQEPKTSEAECGAMDFPEFEDEEEWLFKVLGFKPGPSSALDDDADDQADEPLGAAEFLHLQDILQEDKVSSTDDEDT 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569009949   81 CQAGCTED-DETSHSDRDIDNNVKVITGNIKASPSMYMEMFTDQNPQADQDLEETESDGAMNPTD 144
Cdd:pfam17397  81 CQAGCTEDnDEASHSDRDIDDNVKVIIGDIKANPSMYMEMFTDMNPQADQDLEETESDGAMNPTD 145
 
Name Accession Description Interval E-value
DUF5404 pfam17397
Family of unknown function (DUF5404); This is a family of unknown function found in Chordata. ...
 1-144 5.03e-80

Family of unknown function (DUF5404); This is a family of unknown function found in Chordata. This domain is located downstream the N-terminal of Fip1 pfam05182. Family members such as Swiss:P70537 and Swiss:P70675 contain this domain. The Tsx gene resides at the X-inactivation centre and once thought to encode a protein expressed in testis. However, this was disputed upon further analysis. ORF and immunostaining analysis concluded that Tsx may be non-coding. Tsx long transcript is abundantly expressed in meiotic germ cells, embryonic stem cells, and brain. In vertebrates, Fip1 is the evolutionary precursor of eutherian Tsx, hence its location upstream from the Tsx gene.


Pssm-ID: 340112  Cd Length: 145  Bit Score: 232.71  E-value: 5.03e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009949    1 MSEKQSPKTSEAECSAMDLPEFEDEENWLFKVLGFQPGPSSALDDDTDDQADEPLSAAEFLHLQDILQEDRVSSTDDEDT 80
Cdd:pfam17397   1 MSEEQEPKTSEAECGAMDFPEFEDEEEWLFKVLGFKPGPSSALDDDADDQADEPLGAAEFLHLQDILQEDKVSSTDDEDT 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569009949   81 CQAGCTED-DETSHSDRDIDNNVKVITGNIKASPSMYMEMFTDQNPQADQDLEETESDGAMNPTD 144
Cdd:pfam17397  81 CQAGCTEDnDEASHSDRDIDDNVKVIIGDIKANPSMYMEMFTDMNPQADQDLEETESDGAMNPTD 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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