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Conserved domains on  [gi|569010236|ref|XP_006528144|]
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plasma membrane calcium-transporting ATPase 3 isoform X1 [Mus musculus]

Protein Classification

plasma membrane calcium-transporting ATPase( domain architecture ID 13522140)

plasma membrane calcium-transporting ATPase functions to export Ca(2+) from cells and plays a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ATPase-IIB_Ca super family cl36924
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
19-1061 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


The actual alignment was detected with superfamily member TIGR01517:

Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1354.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236    19 REVPHVGGFGCTLAELRSLMELRGAEALQK---IQEAYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQNFIPPKQP 95
Cdd:TIGR01517    5 RRRTSIRDNFTDGFDVGVSILTDLTDIFKKampLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELPEKPP 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236    96 KTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAP-PGEeseacgnvsggaeDEGEAEAGWIEGAAILLSVICVVLVTAFN 174
Cdd:TIGR01517   85 KSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGE-------------DKADTETGWIEGVAILVSVILVVLVTAVN 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   175 DWSKEKQFRGLQsRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKS 254
Cdd:TIGR01517  152 DYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIKKG 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   255 ADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGaggeeeekkdkkgkqqdgamdssqtrakkqdgavamemqpl 334
Cdd:TIGR01517  231 PVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELR----------------------------------------- 269
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   335 ksaEGGEmeerekkkanvpkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVDGRvwlAECTPVYVQYF 414
Cdd:TIGR01517  270 ---QAGE--------------EETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGR---FEDTEEDAQTF 329
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   415 VKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTH 494
Cdd:TIGR01517  330 LDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQR 409
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   495 YKEIPApsaLTPKILDLLVHAISINSAYTTKILPPEKE-GALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDQLYKV 573
Cdd:TIGR01517  410 FNVRDE---IVLRNLPAAVRNILVEGISLNSSSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKI 486
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   574 YTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPrDRDDMVKKIIEPMACDGLRTICIAYRDF 653
Cdd:TIGR01517  487 YPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISE-DDKDRCADVIEPLASDALRTICLAYRDF 565
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   654 SAIQEPDWDNENevvGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEdfLCLEG 733
Cdd:TIGR01517  566 APEEFPRKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEG 640
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   734 KEFNRRIRNEkgeieqerLDKVWPKLRVLARSSPTDKHTLVKGIIDsttgeQRQVVAVTGDGTNDGPALKKADVGFAMGI 813
Cdd:TIGR01517  641 KEFRSLVYEE--------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGFSMGI 707
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   814 AGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIM 891
Cdd:TIGR01517  708 SGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIM 787
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   892 DTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLTIIFTLLFVGELFFDIDSGRNAPlHSPPSEHYTI 971
Cdd:TIGR01517  788 DTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTI 866
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   972 IFNTFVMMQLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPFSCSPLSTEQWLWCLFVGVGELVW 1051
Cdd:TIGR01517  867 VFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIF 946
                         1050
                   ....*....|
gi 569010236  1052 GQVIATIPTS 1061
Cdd:TIGR01517  947 GVLLRLIPVE 956
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1100-1175 1.17e-18

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


:

Pssm-ID: 463575  Cd Length: 47  Bit Score: 80.53  E-value: 1.17e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569010236  1100 GQILWFRGLNRIQTQmevvstfkrsgsfqgavrrrssvlsqlhdIRVVKAFRSSLYEGLEKPESKSCIHNFMATPE 1175
Cdd:pfam12424    1 GQILWFRGLNRIQTQ-----------------------------IRVVKAFQSSLREGIQKPYLRNSIHSFMSHPE 47
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
19-1061 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1354.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236    19 REVPHVGGFGCTLAELRSLMELRGAEALQK---IQEAYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQNFIPPKQP 95
Cdd:TIGR01517    5 RRRTSIRDNFTDGFDVGVSILTDLTDIFKKampLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELPEKPP 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236    96 KTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAP-PGEeseacgnvsggaeDEGEAEAGWIEGAAILLSVICVVLVTAFN 174
Cdd:TIGR01517   85 KSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGE-------------DKADTETGWIEGVAILVSVILVVLVTAVN 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   175 DWSKEKQFRGLQsRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKS 254
Cdd:TIGR01517  152 DYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIKKG 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   255 ADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGaggeeeekkdkkgkqqdgamdssqtrakkqdgavamemqpl 334
Cdd:TIGR01517  231 PVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELR----------------------------------------- 269
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   335 ksaEGGEmeerekkkanvpkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVDGRvwlAECTPVYVQYF 414
Cdd:TIGR01517  270 ---QAGE--------------EETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGR---FEDTEEDAQTF 329
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   415 VKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTH 494
Cdd:TIGR01517  330 LDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQR 409
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   495 YKEIPApsaLTPKILDLLVHAISINSAYTTKILPPEKE-GALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDQLYKV 573
Cdd:TIGR01517  410 FNVRDE---IVLRNLPAAVRNILVEGISLNSSSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKI 486
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   574 YTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPrDRDDMVKKIIEPMACDGLRTICIAYRDF 653
Cdd:TIGR01517  487 YPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISE-DDKDRCADVIEPLASDALRTICLAYRDF 565
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   654 SAIQEPDWDNENevvGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEdfLCLEG 733
Cdd:TIGR01517  566 APEEFPRKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEG 640
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   734 KEFNRRIRNEkgeieqerLDKVWPKLRVLARSSPTDKHTLVKGIIDsttgeQRQVVAVTGDGTNDGPALKKADVGFAMGI 813
Cdd:TIGR01517  641 KEFRSLVYEE--------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGFSMGI 707
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   814 AGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIM 891
Cdd:TIGR01517  708 SGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIM 787
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   892 DTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLTIIFTLLFVGELFFDIDSGRNAPlHSPPSEHYTI 971
Cdd:TIGR01517  788 DTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTI 866
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   972 IFNTFVMMQLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPFSCSPLSTEQWLWCLFVGVGELVW 1051
Cdd:TIGR01517  867 VFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIF 946
                         1050
                   ....*....|
gi 569010236  1052 GQVIATIPTS 1061
Cdd:TIGR01517  947 GVLLRLIPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
78-925 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1334.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   78 LEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEeseacgnvsggaedeGEAEAGWIEG 157
Cdd:cd02081     1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGE---------------GEGKTGWIEG 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  158 AAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDL 237
Cdd:cd02081    66 VAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDL 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  238 KIDESSLTGESDHVRKSAD---KDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGgeeeekkdkkgkqqdgamd 314
Cdd:cd02081   145 KIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAE------------------- 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  315 ssqtrakkqdgavamemqplksaeggemeerekkkanvpKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIET 394
Cdd:cd02081   206 ---------------------------------------NEEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFIIDG 246
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  395 FVVDGRVWlaecTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 474
Cdd:cd02081   247 FVNDGKSF----SAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 322
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  475 TGTLTTNRMTVVQSYlgdthykeipapsaltpkildllvhaisinsayttkilppekegalprqVGNKTECALLGFVLDL 554
Cdd:cd02081   323 TGTLTQNRMTVVQGY-------------------------------------------------IGNKTECALLGFVLEL 353
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  555 KRDFQpVREQIPEDQLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGElRGFRPRDRDDMVKKI 634
Cdd:cd02081   354 GGDYR-YREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIKRV 431
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  635 IEPMACDGLRTICIAYRDFSAIQEP----DWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNIN 710
Cdd:cd02081   432 IEPMASDSLRTIGLAYRDFSPDEEPtaerDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNIN 511
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  711 TARAIAAKCGIIQPGEDFLCLEGKEFNRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDSttgeqRQVVA 790
Cdd:cd02081   512 TARAIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEVVA 586
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  791 VTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 870
Cdd:cd02081   587 VTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIG 666
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 569010236  871 ACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTM 925
Cdd:cd02081   667 AVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
55-1055 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 703.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   55 DVSGLCRRLKTSPtEGLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLsfyappgees 134
Cdd:COG0474    12 SAEEVLAELGTSE-EGL--SSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL---------- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  135 eacgnvsggaedeGEaeagWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVIRNGQLLQVPVAALVVG 214
Cdd:COG0474    79 -------------GD----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAP--TARVLRDGKWVEIPAEELVPG 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  215 DIAQVKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKSA----------DKDPMLLSGTHVMEGSGRMVVTAVGVNSQ 284
Cdd:COG0474   140 DIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSAdplpedaplgDRGNMVFMGTLVTSGRGTAVVVATGMNTE 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  285 TGIIFTLLGAGgeeeekkdkkgkqqdgamdssqtrakkqdgavamemqplksaeggemeerekkkanvpKKEKSVLQGKL 364
Cdd:COG0474   220 FGKIAKLLQEA----------------------------------------------------------EEEKTPLQKQL 241
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  365 TKLAVQIGKAGLVMSAITVIILVLYfvietfvvdGRVWLAectpvyvqyfvkFFIIGVTVLVVAVPEGLPLAVTISLAYS 444
Cdd:COG0474   242 DRLGKLLAIIALVLAALVFLIGLLR---------GGPLLE------------ALLFAVALAVAAIPEGLPAVVTITLALG 300
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  445 VKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYkeipAPSALTPKILDLLVHAISINSAYTt 524
Cdd:COG0474   301 AQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY----EVTGEFDPALEELLRAAALCSDAQ- 375
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  525 kiLPPEKEgalprqVGNKTECALLGFVLDLKRDFQPVREQIPedqLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEI 604
Cdd:COG0474   376 --LEEETG------LGDPTEGALLVAAAKAGLDVEELRKEYP---RVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEV 444
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  605 LLKKCTNILnSNGELRGFRPRDRDDMVKKIIEpMACDGLRTICIAYRDFSAIQEPDwdnENEVVGDLTCIAVVGIEDPVR 684
Cdd:COG0474   445 VLALCTRVL-TGGGVVPLTEEDRAEILEAVEE-LAAQGLRVLAVAYKELPADPELD---SEDDESDLTFLGLVGMIDPPR 519
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  685 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDflCLEGKEFNRrirnekgeIEQERLDKVWPKLRVLAR 764
Cdd:COG0474   520 PEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA--------MSDEELAEAVEDVDVFAR 589
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  765 SSPTDKHTLVKGIidsttgeQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWG 842
Cdd:COG0474   590 VSPEHKLRIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEG 662
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  843 RNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLIS 922
Cdd:COG0474   663 RRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILS 742
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  923 RTMMKNILGHAVyqLTIIFTLLFvgeLFFDIDSGRNAPLHSppsehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIF 1001
Cdd:COG0474   743 RFLLLRILLLGL--LIAIFTLLT---FALALARGASLALAR------TMAFTTLVLSQLFNVFNCRSER--RSFFKsGLF 809
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 569010236 1002 SNPIFCTIVLGTFGIQIVIVQ--FGGKPFSCSPLSTEQWLWCLFVGVGELVWGQVI 1055
Cdd:COG0474   810 PNRPLLLAVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLILGLALLYLLLVELV 865
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
877-1055 2.34e-50

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 175.89  E-value: 2.34e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   877 SPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLTIIFTLLFVGELFFDIDSG 956
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   957 RNAplhsppsehYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFSNPIFCTIVLGTFGIQIVIVQ--FGGKPFSCSPLS 1034
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 569010236  1035 TEQWLWCLFVGVGELVWGQVI 1055
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
55-867 4.93e-50

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 192.59  E-value: 4.93e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   55 DVSGLCRRLKTSPtEGLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSlglsfYAppgees 134
Cdd:PRK10517   53 PEEELWKTFDTHP-EGL--NEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNPFNILLTILGAIS-----YA------ 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  135 eacgnvsggAEDEGeaeagwiegAAILLSVIcVVLVTAFNDWSKEKQFRG---LQSRIEQeqKFTVIRNG------QLLQ 205
Cdd:PRK10517  119 ---------TEDLF---------AAGVIALM-VAISTLLNFIQEARSTKAadaLKAMVSN--TATVLRVIndkgenGWLE 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  206 VPVAALVVGDIAQVKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKSA-----------DKDPMLLSGTHVMEGSGRM 274
Cdd:PRK10517  178 IPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKFAttrqpehsnplECDTLCFMGTNVVSGTAQA 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  275 VVTAVGVNsqtgiifTLLGAGGeeeekkdkkgkqqdgamdssqTRAKKQDGAVamemqplksaeggemeerekkkanvpk 354
Cdd:PRK10517  258 VVIATGAN-------TWFGQLA---------------------GRVSEQDSEP--------------------------- 282
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  355 kekSVLQGKLTKLAVQIGKAGLVMSAItviilVLYfvIETFVvDGRVWLAectpvyvqyfvkfFIIGVTVLVVAVPEGLP 434
Cdd:PRK10517  283 ---NAFQQGISRVSWLLIRFMLVMAPV-----VLL--INGYT-KGDWWEA-------------ALFALSVAVGLTPEMLP 338
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  435 LAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQsylgdtHYKEIPAPSaltpkilDLLVH 514
Cdd:PRK10517  339 MIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIVLEN------HTDISGKTS-------ERVLH 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  515 AISINSAYTTKIlppekEGALPRQVgnkTECALLGFVLDLKRDFQPVREqIPedqlykvytFNSVRKSMSTVIRMPDGGF 594
Cdd:PRK10517  406 SAWLNSHYQTGL-----KNLLDTAV---LEGVDEESARSLASRWQKIDE-IP---------FDFERRRMSVVVAENTEHH 467
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  595 RLFSKGASEILLKKCTNILNsNGELRGFRPrDRDDMVKKIIEPMACDGLRTICIAYRDFSAIQEpDWDNENEvvGDLTCI 674
Cdd:PRK10517  468 QLICKGALEEILNVCSQVRH-NGEIVPLDD-IMLRRIKRVTDTLNRQGLRVVAVATKYLPAREG-DYQRADE--SDLILE 542
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  675 AVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNintaRAIAAKcgiiqpgedfLCLE-GKEFNRRIRNekGEIEQ---E 750
Cdd:PRK10517  543 GYIAFLDPPKETTAPALKALKASGVTVKILTGDS----ELVAAK----------VCHEvGLDAGEVLIG--SDIETlsdD 606
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  751 RLDKVWPKLRVLARSSPTDKHTLVKGIIDsttgeQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDD 830
Cdd:PRK10517  607 ELANLAERTTLFARLTPMHKERIVTLLKR-----EGHVVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADIILLEK 680
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|..
gi 569010236  831 NFTSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVA 867
Cdd:PRK10517  681 SLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1100-1175 1.17e-18

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 80.53  E-value: 1.17e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569010236  1100 GQILWFRGLNRIQTQmevvstfkrsgsfqgavrrrssvlsqlhdIRVVKAFRSSLYEGLEKPESKSCIHNFMATPE 1175
Cdd:pfam12424    1 GQILWFRGLNRIQTQ-----------------------------IRVVKAFQSSLREGIQKPYLRNSIHSFMSHPE 47
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
59-124 4.47e-11

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 59.90  E-value: 4.47e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569010236     59 LCRRLKTSPTEGLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGL 124
Cdd:smart00831   12 VLERLQTDLEKGL--SSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
19-1061 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1354.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236    19 REVPHVGGFGCTLAELRSLMELRGAEALQK---IQEAYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQNFIPPKQP 95
Cdd:TIGR01517    5 RRRTSIRDNFTDGFDVGVSILTDLTDIFKKampLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELPEKPP 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236    96 KTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAP-PGEeseacgnvsggaeDEGEAEAGWIEGAAILLSVICVVLVTAFN 174
Cdd:TIGR01517   85 KSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGE-------------DKADTETGWIEGVAILVSVILVVLVTAVN 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   175 DWSKEKQFRGLQsRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKS 254
Cdd:TIGR01517  152 DYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIKKG 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   255 ADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGaggeeeekkdkkgkqqdgamdssqtrakkqdgavamemqpl 334
Cdd:TIGR01517  231 PVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELR----------------------------------------- 269
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   335 ksaEGGEmeerekkkanvpkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVDGRvwlAECTPVYVQYF 414
Cdd:TIGR01517  270 ---QAGE--------------EETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGR---FEDTEEDAQTF 329
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   415 VKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTH 494
Cdd:TIGR01517  330 LDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQR 409
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   495 YKEIPApsaLTPKILDLLVHAISINSAYTTKILPPEKE-GALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDQLYKV 573
Cdd:TIGR01517  410 FNVRDE---IVLRNLPAAVRNILVEGISLNSSSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKI 486
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   574 YTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPrDRDDMVKKIIEPMACDGLRTICIAYRDF 653
Cdd:TIGR01517  487 YPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISE-DDKDRCADVIEPLASDALRTICLAYRDF 565
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   654 SAIQEPDWDNENevvGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEdfLCLEG 733
Cdd:TIGR01517  566 APEEFPRKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEG 640
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   734 KEFNRRIRNEkgeieqerLDKVWPKLRVLARSSPTDKHTLVKGIIDsttgeQRQVVAVTGDGTNDGPALKKADVGFAMGI 813
Cdd:TIGR01517  641 KEFRSLVYEE--------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGFSMGI 707
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   814 AGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIM 891
Cdd:TIGR01517  708 SGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIM 787
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   892 DTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLTIIFTLLFVGELFFDIDSGRNAPlHSPPSEHYTI 971
Cdd:TIGR01517  788 DTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTI 866
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   972 IFNTFVMMQLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPFSCSPLSTEQWLWCLFVGVGELVW 1051
Cdd:TIGR01517  867 VFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIF 946
                         1050
                   ....*....|
gi 569010236  1052 GQVIATIPTS 1061
Cdd:TIGR01517  947 GVLLRLIPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
78-925 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1334.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   78 LEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEeseacgnvsggaedeGEAEAGWIEG 157
Cdd:cd02081     1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGE---------------GEGKTGWIEG 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  158 AAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDL 237
Cdd:cd02081    66 VAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDL 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  238 KIDESSLTGESDHVRKSAD---KDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGgeeeekkdkkgkqqdgamd 314
Cdd:cd02081   145 KIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAE------------------- 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  315 ssqtrakkqdgavamemqplksaeggemeerekkkanvpKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIET 394
Cdd:cd02081   206 ---------------------------------------NEEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFIIDG 246
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  395 FVVDGRVWlaecTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 474
Cdd:cd02081   247 FVNDGKSF----SAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 322
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  475 TGTLTTNRMTVVQSYlgdthykeipapsaltpkildllvhaisinsayttkilppekegalprqVGNKTECALLGFVLDL 554
Cdd:cd02081   323 TGTLTQNRMTVVQGY-------------------------------------------------IGNKTECALLGFVLEL 353
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  555 KRDFQpVREQIPEDQLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGElRGFRPRDRDDMVKKI 634
Cdd:cd02081   354 GGDYR-YREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIKRV 431
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  635 IEPMACDGLRTICIAYRDFSAIQEP----DWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNIN 710
Cdd:cd02081   432 IEPMASDSLRTIGLAYRDFSPDEEPtaerDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNIN 511
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  711 TARAIAAKCGIIQPGEDFLCLEGKEFNRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDSttgeqRQVVA 790
Cdd:cd02081   512 TARAIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEVVA 586
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  791 VTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 870
Cdd:cd02081   587 VTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIG 666
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 569010236  871 ACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTM 925
Cdd:cd02081   667 AVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
55-1055 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 703.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   55 DVSGLCRRLKTSPtEGLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLsfyappgees 134
Cdd:COG0474    12 SAEEVLAELGTSE-EGL--SSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL---------- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  135 eacgnvsggaedeGEaeagWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVIRNGQLLQVPVAALVVG 214
Cdd:COG0474    79 -------------GD----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAP--TARVLRDGKWVEIPAEELVPG 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  215 DIAQVKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKSA----------DKDPMLLSGTHVMEGSGRMVVTAVGVNSQ 284
Cdd:COG0474   140 DIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSAdplpedaplgDRGNMVFMGTLVTSGRGTAVVVATGMNTE 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  285 TGIIFTLLGAGgeeeekkdkkgkqqdgamdssqtrakkqdgavamemqplksaeggemeerekkkanvpKKEKSVLQGKL 364
Cdd:COG0474   220 FGKIAKLLQEA----------------------------------------------------------EEEKTPLQKQL 241
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  365 TKLAVQIGKAGLVMSAITVIILVLYfvietfvvdGRVWLAectpvyvqyfvkFFIIGVTVLVVAVPEGLPLAVTISLAYS 444
Cdd:COG0474   242 DRLGKLLAIIALVLAALVFLIGLLR---------GGPLLE------------ALLFAVALAVAAIPEGLPAVVTITLALG 300
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  445 VKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYkeipAPSALTPKILDLLVHAISINSAYTt 524
Cdd:COG0474   301 AQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY----EVTGEFDPALEELLRAAALCSDAQ- 375
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  525 kiLPPEKEgalprqVGNKTECALLGFVLDLKRDFQPVREQIPedqLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEI 604
Cdd:COG0474   376 --LEEETG------LGDPTEGALLVAAAKAGLDVEELRKEYP---RVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEV 444
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  605 LLKKCTNILnSNGELRGFRPRDRDDMVKKIIEpMACDGLRTICIAYRDFSAIQEPDwdnENEVVGDLTCIAVVGIEDPVR 684
Cdd:COG0474   445 VLALCTRVL-TGGGVVPLTEEDRAEILEAVEE-LAAQGLRVLAVAYKELPADPELD---SEDDESDLTFLGLVGMIDPPR 519
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  685 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDflCLEGKEFNRrirnekgeIEQERLDKVWPKLRVLAR 764
Cdd:COG0474   520 PEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA--------MSDEELAEAVEDVDVFAR 589
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  765 SSPTDKHTLVKGIidsttgeQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWG 842
Cdd:COG0474   590 VSPEHKLRIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEG 662
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  843 RNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLIS 922
Cdd:COG0474   663 RRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILS 742
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  923 RTMMKNILGHAVyqLTIIFTLLFvgeLFFDIDSGRNAPLHSppsehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIF 1001
Cdd:COG0474   743 RFLLLRILLLGL--LIAIFTLLT---FALALARGASLALAR------TMAFTTLVLSQLFNVFNCRSER--RSFFKsGLF 809
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 569010236 1002 SNPIFCTIVLGTFGIQIVIVQ--FGGKPFSCSPLSTEQWLWCLFVGVGELVWGQVI 1055
Cdd:COG0474   810 PNRPLLLAVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLILGLALLYLLLVELV 865
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
70-913 7.92e-169

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 516.78  E-value: 7.92e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   70 GLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLsfyappgeeseacgnvsggaedege 149
Cdd:cd02089     1 GL--SEEEAERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVL------------------------- 53
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  150 aeAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRieQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADG 229
Cdd:cd02089    54 --GEYVDAIVIIAIVILNAVLGFVQEYKAEKALAALKKM--SAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADG 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  230 VLIQGNDLKIDESSLTGESDHVRKSADKDP-----------MLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGgee 298
Cdd:cd02089   130 RLIESASLRVEESSLTGESEPVEKDADTLLeedvplgdrknMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEET--- 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  299 eekkdkkgkqqdgamdssqtrakkqdgavamemqplksaeggemeerekkkanvpKKEKSVLQGKLTKLAVQIGKAGLVM 378
Cdd:cd02089   207 -------------------------------------------------------EEEKTPLQKRLDQLGKRLAIAALII 231
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  379 SAITVIILVLYfvietfvvdGRVWLAEctpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHL 458
Cdd:cd02089   232 CALVFALGLLR---------GEDLLDM------------LLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIRKL 290
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  459 DACETMGNATAICSDKTGTLTTNRMTVVQSY-LGDthykeiPAPSALtpkildllvhaisINSAYTTKILPPEKEGALPR 537
Cdd:cd02089   291 PAVETLGSVSVICSDKTGTLTQNKMTVEKIYtIGD------PTETAL-------------IRAARKAGLDKEELEKKYPR 351
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  538 QvgnktecallgfvldlkrdfqpvrEQIPedqlykvytFNSVRKSMSTVIRMPDGgFRLFSKGASEILLKKCTNILNsNG 617
Cdd:cd02089   352 I------------------------AEIP---------FDSERKLMTTVHKDAGK-YIVFTKGAPDVLLPRCTYIYI-NG 396
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  618 ELRGFRPRDRDDmVKKIIEPMACDGLRTICIAYRDfsaIQEPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRA 697
Cdd:cd02089   397 QVRPLTEEDRAK-ILAVNEEFSEEALRVLAVAYKP---LDEDPTESSEDLENDLIFLGLVGMIDPPRPEVKDAVAECKKA 472
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  698 GITVRMVTGDNINTARAIAAKCGIIQPGEdfLCLEGKEFNrrirnekgEIEQERLDKVWPKLRVLARSSPTDKHTLVKGI 777
Cdd:cd02089   473 GIKTVMITGDHKLTARAIAKELGILEDGD--KALTGEELD--------KMSDEELEKKVEQISVYARVSPEHKLRIVKAL 542
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  778 idsttgeQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQF 855
Cdd:cd02089   543 -------QRKgkIVAMTGDGVNDAPALKAADIGVAMGITGTDVAKEAADMILTDDNFATIVAAVEEGRTIYDNIRKFIRY 615
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 569010236  856 QLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKP 913
Cdd:cd02089   616 LLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALGVEPAEPDIMDRKP 673
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
79-1046 9.69e-148

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 466.35  E-value: 9.69e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   79 EKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFyappgeeseacgnvsggaedegeaeagWIEGA 158
Cdd:cd02080     8 AERLERYGPNRLPEKKTKSPLLRFLRQFNNPLIYILLAAAVVTAFLGH---------------------------WVDAI 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  159 AILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQkfTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLK 238
Cdd:cd02080    61 VIFGVVLINAIIGYIQEGKAEKALAAIKNMLSPEA--TVLRDGKKLTIDAEELVPGDIVLLEAGDKVPADLRLIEARNLQ 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  239 IDESSLTGESDHVRKS----------ADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGgeeeekkdkkgkq 308
Cdd:cd02080   139 IDESALTGESVPVEKQegpleedtplGDRKNMAYSGTLVTAGSATGVVVATGADTEIGRINQLLAEV------------- 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  309 qdgamDSSQTrakkqdgavamemqplksaeggemeerekkkanvPkkeksvLQGKLTKLAVQIGKAGLVMSAITVIIlvl 388
Cdd:cd02080   206 -----EQLAT----------------------------------P------LTRQIAKFSKALLIVILVLAALTFVF--- 237
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  389 yfvieTFVVDGRVWlaectpvyvqyfVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNAT 468
Cdd:cd02080   238 -----GLLRGDYSL------------VELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVETLGSVT 300
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  469 AICSDKTGTLTTNRMTVVQSYLgdthykeipapsaltpkildllvhaiSINSAYttkiLPPEKEGAlpRQVGNKTECALL 548
Cdd:cd02080   301 VICSDKTGTLTRNEMTVQAIVT--------------------------LCNDAQ----LHQEDGHW--KITGDPTEGALL 348
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  549 GFVLDLKRDFQPVREQIPEdqlYKVYTFNSVRKSMSTVIRMpDGGFRLFSKGASEILLKKCTNILNSNGElrgfRPRDRD 628
Cdd:cd02080   349 VLAAKAGLDPDRLASSYPR---VDKIPFDSAYRYMATLHRD-DGQRVIYVKGAPERLLDMCDQELLDGGV----SPLDRA 420
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  629 dMVKKIIEPMACDGLRTICIAYRDFSaiQEPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDN 708
Cdd:cd02080   421 -YWEAEAEDLAKQGLRVLAFAYREVD--SEVEEIDHADLEGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDH 497
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  709 INTARAIAAKCGIIQPGEdflCLEGKEFNRrirnekgeIEQERLDKVWPKLRVLARSSPTDKHTLVKGIidSTTGEqrqV 788
Cdd:cd02080   498 AETARAIGAQLGLGDGKK---VLTGAELDA--------LDDEELAEAVDEVDVFARTSPEHKLRLVRAL--QARGE---V 561
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  789 VAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNV---VAVI 865
Cdd:cd02080   562 VAMTGDGVNDAPALKQADIGIAMGIKGTEVAKEAADMVLADDNFATIAAAVEEGRRVYDNLKKFILFTLPTNLgegLVII 641
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  866 VA-FTGACItqdsPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILghAVYQLTIIFTL- 943
Cdd:cd02080   642 VAiLFGVTL----PLTPVQILWINMVTAITLGLALAFEPAEPGIMKRPPRDPSEPLLSRELIWRIL--LVSLLMLGGAFg 715
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  944 LFVGELF--FDIDSGRnaplhsppsehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIFSNPIFCTIVLGTFGIQIVI 1020
Cdd:cd02080   716 LFLWALDrgYSLETAR------------TMAVNTIVVAQIFYLFNCRSLH--RSILKlGVFSNKILFLGIGALILLQLAF 781
                         970       980
                  ....*....|....*....|....*...
gi 569010236 1021 VQ--FGGKPFSCSPLSTEQWLWCLFVGV 1046
Cdd:cd02080   782 TYlpFMNSLFGTAPIDLVDWAIILLVGI 809
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
160-899 1.13e-147

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 456.78  E-value: 1.13e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   160 ILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRNGQLlQVPVAALVVGDIAQVKYGDLLPADGVLIQGnDLKI 239
Cdd:TIGR01494    2 ILFLVLLFVLLEVKQKLKAEDALRSLKDSLVNTATVLVLRNGWK-EISSKDLVPGDVVLVKSGDTVPADGVLLSG-SAFV 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   240 DESSLTGESDHVRKSADKDP-MLLSGTHVMEGSGRMVVTAVGVNSQTGIIftllgaggeeeekkdkkgkqqdgamdssqt 318
Cdd:TIGR01494   80 DESSLTGESLPVLKTALPDGdAVFAGTINFGGTLIVKVTATGILTTVGKI------------------------------ 129
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   319 rakkqdgAVAMEmqplksaEGGEmeerekkkanvpkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFvvd 398
Cdd:TIGR01494  130 -------AVVVY-------TGFS--------------TKTPLQSKADKFENFIFILFLLLLALAVFLLLPIGGWDGN--- 178
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   399 grvwlaectpvyvqYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTL 478
Cdd:TIGR01494  179 --------------SIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVKNLNALEELGKVDVICFDKTGTL 244
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   479 TTNRMTVVQSYLGDTHYKEIPAPSALTpkildllvhaisinsayttkilppekeGALPRQVGNKTECALLGFVldlKRDF 558
Cdd:TIGR01494  245 TTNKMTLQKVIIIGGVEEASLALALLA---------------------------ASLEYLSGHPLERAIVKSA---EGVI 294
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   559 QpVREQIPEDQLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNsngelrgfrprdrddmVKKIIEPM 638
Cdd:TIGR01494  295 K-SDEINVEYKILDVFPFSSVLKRMGVIVEGANGSDLLFVKGAPEFVLERCNNEND----------------YDEKVDEY 357
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   639 ACDGLRTICIAYRDFSaiqepdwdnenevvGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAK 718
Cdd:TIGR01494  358 ARQGLRVLAFASKKLP--------------DDLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAIAKE 423
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   719 CGIIqpgedflclegkefnrrirnekgeieqerldkvwpklrVLARSSPTDKHTLVKGIIdsttgEQRQVVAVTGDGTND 798
Cdd:TIGR01494  424 LGID--------------------------------------VFARVKPEEKAAIVEALQ-----EKGRTVAMTGDGVND 460
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   799 GPALKKADVGFAMGIAgtDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACItqdsp 878
Cdd:TIGR01494  461 APALKKADVGIAMGSG--DVAKAAADIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIVI----- 533
                          730       740
                   ....*....|....*....|.
gi 569010236   879 lkavqmlwvNLIMDTFASLAL 899
Cdd:TIGR01494  534 ---------ILLPPLLAALAL 545
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
55-922 3.08e-140

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 451.36  E-value: 3.08e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   55 DVSGLCRRLKTSPTEGLADNtnDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYappgees 134
Cdd:cd02083     4 TVEEVLAYFGVDPTRGLSDE--QVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALF------- 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  135 eacgnvsggaEDEGEAEAGWIEGAAILLSVIC--VVLVtafndWskekQFRGLQSRIEQEQKF-----TVIRNGQLLQ-V 206
Cdd:cd02083    75 ----------EEGEEGVTAFVEPFVILLILIAnaVVGV-----W----QERNAEKAIEALKEYepemaKVLRNGKGVQrI 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  207 PVAALVVGDIAQVKYGDLLPADG--VLIQGNDLKIDESSLTGESDHVRKSAD--KDP---------MLLSGTHVMEGSGR 273
Cdd:cd02083   136 RARELVPGDIVEVAVGDKVPADIriIEIKSTTLRVDQSILTGESVSVIKHTDvvPDPravnqdkknMLFSGTNVAAGKAR 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  274 MVVTAVGVNSQTGIIFTllgaggeeeekkdkkgkqqdgamdssqtrakkqdgavamemqplksaeggEMEEREKkkanvp 353
Cdd:cd02083   216 GVVVGTGLNTEIGKIRD--------------------------------------------------EMAETEE------ 239
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  354 kkEKSVLQGKLTKLAVQIGKAglvmsaITVIILVLYFV-IETFVvdgrvwlaecTPVYVQYFVK----FFIIGVTVLVVA 428
Cdd:cd02083   240 --EKTPLQQKLDEFGEQLSKV------ISVICVAVWAInIGHFN----------DPAHGGSWIKgaiyYFKIAVALAVAA 301
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  429 VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTV-----VQSYLGDTHYKEIP---- 499
Cdd:cd02083   302 IPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVsrmfiLDKVEDDSSLNEFEvtgs 381
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  500 ----------APSALTPKILDLLVHAISINSAYTTKILPPEKEGALPRQVGNKTECALLGFV------------LDLKRD 557
Cdd:cd02083   382 tyapegevfkNGKKVKAGQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVekmnvfntdksgLSKRER 461
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  558 FQPVREQIpEDQLYKVYT--FNSVRKSMSTVIR--MPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPRDRDDMVKK 633
Cdd:cd02083   462 ANACNDVI-EQLWKKEFTleFSRDRKSMSVYCSptKASGGNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAAIKILILKK 540
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  634 IIEpMACDGLRTICIAYRDFSAIQEP----DWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNI 709
Cdd:cd02083   541 VWG-YGTDTLRCLALATKDTPPKPEDmdleDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNK 619
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  710 NTARAIAAKCGIIQPGEDFlclEGKEFNRRIRNEKGEIEQErldKVWPKLRVLARSSPTDKHTLVKGIidsttGEQRQVV 789
Cdd:cd02083   620 GTAEAICRRIGIFGEDEDT---TGKSYTGREFDDLSPEEQR---EACRRARLFSRVEPSHKSKIVELL-----QSQGEIT 688
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  790 AVTGDGTNDGPALKKADVGFAMGIaGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFT 869
Cdd:cd02083   689 AMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFL 767
                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|...
gi 569010236  870 GACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLIS 922
Cdd:cd02083   768 TAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMKKPPRKPDEPLIS 820
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
102-1044 8.39e-128

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 416.11  E-value: 8.39e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   102 VWEALQDVTLIILEVAAIVSLGLSFYappgeeseacgnvsggaEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQ 181
Cdd:TIGR01116    1 VLEQFEDLLVRILLLAACVSFVLAWF-----------------EEGEETVTAFVEPFVILLILVANAIVGVWQERNAEKA 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   182 FRGLQSrIEQEQKfTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKSA------ 255
Cdd:TIGR01116   64 IEALKE-YESEHA-KVLRDGRWSVIKAKDLVPGDIVELAVGDKVPADIRVLSLKTLRVDQSILTGESVSVNKHTesvpde 141
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   256 -----DKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIftllgaggeeeekkdkkgkqqdgamdssqtrakkQDgavame 330
Cdd:TIGR01116  142 ravnqDKKNMLFSGTLVVAGKARGVVVRTGMSTEIGKI----------------------------------RD------ 181
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   331 mqplksaeggEMEEREKkkanvpkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFviETFVVDGRvwlaectpvY 410
Cdd:TIGR01116  182 ----------EMRAAEQ--------EDTPLQKKLDEFGELLSKVIGLICILVWVINIGHF--NDPALGGG---------W 232
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   411 VQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTV----- 485
Cdd:TIGR01116  233 IQGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVckvva 312
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   486 -------VQSY-LGDTHYKEIPA----PSALTPKILDLLVHAISINSAYTTKILPPEKEGALPRQVGNKTECALLGFV-- 551
Cdd:TIGR01116  313 ldpssssLNEFcVTGTTYAPEGGvikdDGPVAGGQDAGLEELATIAALCNDSSLDFNERKGVYEKVGEATEAALKVLVek 392
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   552 ---LDLKRDFQPVRE------QIPEDQLYKVYT--FNSVRKSMStVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELR 620
Cdd:TIGR01116  393 mglPATKNGVSSKRRpalgcnSVWNDKFKKLATleFSRDRKSMS-VLCKPSTGNKLFVKGAPEGVLERCTHILNGDGRAV 471
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   621 GFRPRDRDDMVKKIIEPMACDGLRTICIAYRDFSAIQE----PDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQR 696
Cdd:TIGR01116  472 PLTDKMKNTILSVIKEMGTTKALRCLALAFKDIPDPREedllSDPANFEAIESDLTFIGVVGMLDPPRPEVADAIEKCRT 551
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   697 AGITVRMVTGDNINTARAIAAKCGIIQPGED--FLCLEGKEFNrrirnekgEIEQERLDKVWPKLRVLARSSPTDKHTLV 774
Cdd:TIGR01116  552 AGIRVIMITGDNKETAEAICRRIGIFSPDEDvtFKSFTGREFD--------EMGPAKQRAACRSAVLFSRVEPSHKSELV 623
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   775 KgiidsTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQ 854
Cdd:TIGR01116  624 E-----LLQEQGEIVAMTGDGVNDAPALKKADIGIAMG-SGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIR 697
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   855 FQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLIS-----RTMmknI 929
Cdd:TIGR01116  698 YMISSNIGEVVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITgwlffRYL---V 774
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   930 LGHAVYQLTI---IFTLLFVGELFFDIDSGRNAP--------LHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFd 998
Cdd:TIGR01116  775 VGVYVGLATVggfVWWYLLTHFTGCDEDSFTTCPdfedpdcyVFEGKQPARTISLSVLVVIEMFNALNALSEDQSLLRM- 853
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....*...
gi 569010236   999 GIFSNPIFCTIVLGTFGIQIVI--VQFGGKPFSCSPLSTEQWLWCLFV 1044
Cdd:TIGR01116  854 PPWVNKWLIGAICLSMALHFLIlyVPFLSRIFGVTPLSLTDWLMVLKL 901
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
81-1023 8.83e-120

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 391.38  E-value: 8.83e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   81 RRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLglsfyappgeeseacgnVSGGAEDegeaeagwieGAAI 160
Cdd:cd02085     1 RRKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSV-----------------VMKQYDD----------AVSI 53
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  161 LLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEqkFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLKID 240
Cdd:cd02085    54 TVAILIVVTVAFVQEYRSEKSLEALNKLVPPE--CHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSID 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  241 ESSLTGESDHVRKS------------ADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAggeeeekkdkkgkq 308
Cdd:cd02085   132 ESSLTGETEPCSKTtevipkasngdlTTRSNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQA-------------- 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  309 qdgamdssqtrakkqdgavamemqplksaeggemEErekkkanvpkKEKSVLQGKLTKLAVQigkaglvMSAITVIILVL 388
Cdd:cd02085   198 ----------------------------------EE----------APKTPLQKSMDKLGKQ-------LSLYSFIIIGV 226
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  389 YFVIETFvvDGRVWLaectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNAT 468
Cdd:cd02085   227 IMLIGWL--QGKNLL------------EMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVN 292
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  469 AICSDKTGTLTTNRMTVVQsylgdthykeipapsaltpkildlLVHAISINSAYTTKILPPekegalprqvGNKTECALL 548
Cdd:cd02085   293 VICSDKTGTLTKNEMTVTK------------------------IVTGCVCNNAVIRNNTLM----------GQPTEGALI 338
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  549 gfVLDLKRDFQPVREQIpedQLYKVYTFNSVRKSMSTVIRMPDGGFR---LFSKGASEILLKKCTNILNSNGELRGFRPR 625
Cdd:cd02085   339 --ALAMKMGLSDIRETY---IRKQEIPFSSEQKWMAVKCIPKYNSDNeeiYFMKGALEQVLDYCTTYNSSDGSALPLTQQ 413
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  626 DRDdMVKKIIEPMACDGLRTICIAyrdfsaiqepdwdnENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVT 705
Cdd:cd02085   414 QRS-EINEEEKEMGSKGLRVLALA--------------SGPELGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKMIT 478
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  706 GDNINTARAIAAKCGIIQPGEdfLCLEGKEFNRrirnekgeIEQERLDKVWPKLRVLARSSPTDKHTLVKGIidSTTGEq 785
Cdd:cd02085   479 GDAQETAIAIGSSLGLYSPSL--QALSGEEVDQ--------MSDSQLASVVRKVTVFYRASPRHKLKIVKAL--QKSGA- 545
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  786 rqVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVI 865
Cdd:cd02085   546 --VVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEGKGIFYNIKNFVRFQLSTSIAALS 623
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  866 VAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVyqLTIIFTL-L 944
Cdd:cd02085   624 LIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILTRSLILNVLLSAA--IIVSGTLwV 701
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  945 FVGELFFDIDSGRNAplhsppsehyTIIFNTFVMMQLFNEINARkiHGERNVFD-GIFSNPIFCTIVLGTFGIQIVIVQF 1023
Cdd:cd02085   702 FWKEMSDDNVTPRDT----------TMTFTCFVFFDMFNALSCR--SQTKSIFEiGFFSNRMFLYAVGGSLIGQLLVIYF 769
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
154-1020 1.65e-118

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 391.05  E-value: 1.65e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  154 WIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKftVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQ 233
Cdd:cd02086    56 WIEGGVIAAVIALNVIVGFIQEYKAEKTMDSLRNLSSPNAH--VIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIE 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  234 GNDLKIDESSLTGESDHVRKSA-------------DKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLgaggeeee 300
Cdd:cd02086   134 TKNFETDEALLTGESLPVIKDAelvfgkeedvsvgDRLNLAYSSSTVTKGRAKGIVVATGMNTEIGKIAKAL-------- 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  301 kkdkkgkqqdgamdssQTRAKKQDgavameMQPLKSAEGGEMEEREKKKANV-PKKEKSVLQGKLTKLAVqigkaglVMS 379
Cdd:cd02086   206 ----------------RGKGGLIS------RDRVKSWLYGTLIVTWDAVGRFlGTNVGTPLQRKLSKLAY-------LLF 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  380 AITVIILVLYFVIETFVVDGRVwlaectpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLD 459
Cdd:cd02086   257 FIAVILAIIVFAVNKFDVDNEV----------------IIYAIALAISMIPESLVAVLTITMAVGAKRMVKRNVIVRKLD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  460 ACETMGNATAICSDKTGTLTTNRMTVVQSYLgdthykeipaPSALTpkildllvhaisiNSAYTTKilppEKEGALPRQV 539
Cdd:cd02086   321 ALEALGAVTDICSDKTGTLTQGKMVVRQVWI----------PAALC-------------NIATVFK----DEETDCWKAH 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  540 GNKTECALLGFV--LDLKRDFQPVREQiPEDQLYKVYTFNSVRKSMSTVIRMPDGGFR-LFSKGASEILLKKCTNILNSN 616
Cdd:cd02086   374 GDPTEIALQVFAtkFDMGKNALTKGGS-AQFQHVAEFPFDSTVKRMSVVYYNNQAGDYyAYMKGAVERVLECCSSMYGKD 452
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  617 GELRGFRPrDRDDMVKKIiEPMACDGLRTICIAYRDFS--AIQEPDWDN---ENEVV-GDLTCIAVVGIEDPVRPEVPEA 690
Cdd:cd02086   453 GIIPLDDE-FRKTIIKNV-ESLASQGLRVLAFASRSFTkaQFNDDQLKNitlSRADAeSDLTFLGLVGIYDPPRNESAGA 530
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  691 IRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGE--------DFLCLEGKEFNRRIRNEKGEIEQERLdkvwpklrVL 762
Cdd:cd02086   531 VEKCHQAGITVHMLTGDHPGTAKAIAREVGILPPNSyhysqeimDSMVMTASQFDGLSDEEVDALPVLPL--------VI 602
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  763 ARSSPTDKhtlVKGIidsTTGEQR-QVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMW 841
Cdd:cd02086   603 ARCSPQTK---VRMI---EALHRRkKFCAMTGDGVNDSPSLKMADVGIAMGLNGSDVAKDASDIVLTDDNFASIVNAIEE 676
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  842 GRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS-----PLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGR 916
Cdd:cd02086   677 GRRMFDNIQKFVLHLLAENVAQVILLLIGLAFKDEDglsvfPLSPVEILWINMVTSSFPAMGLGLEKASPDVMQRPPHDL 756
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  917 DKPLISRTMMKNILghaVYQLTIIFTLL--FVGELFF----DIDSGRNAPLHSPPSEHY---TIIFNTFVMMQLF---NE 984
Cdd:cd02086   757 KVGIFTRELIIDTF---VYGTFMGVLCLasFTLVIYGigngDLGSDCNESYNSSCEDVFrarAAVFATLTWCALIlawEV 833
                         890       900       910       920
                  ....*....|....*....|....*....|....*....|....*.
gi 569010236  985 INARK----IHGE-----RNVFDGIFSNP-IFCTIVLGTFGIQIVI 1020
Cdd:cd02086   834 VDMRRsffnMHPDtdspvKSFFKTLWKNKfLFWSVVLGFVSVFPTL 879
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
470-899 1.74e-97

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 314.00  E-value: 1.74e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  470 ICSDKTGTLTTNRMTVVqsylgDTHYKEIPapsaltpkildllvhaisinsayttkilppekegalprqvgnktecallg 549
Cdd:cd01431     2 ICSDKTGTLTKNGMTVT-----KLFIEEIP-------------------------------------------------- 26
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  550 fvldlkrdfqpvreqipedqlykvytFNSVRKSMSTVIRMPdGGFRLFSKGASEILLKKCTNILnsngelrgfrPRDRDD 629
Cdd:cd01431    27 --------------------------FNSTRKRMSVVVRLP-GRYRAIVKGAPETILSRCSHAL----------TEEDRN 69
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  630 MVKKIIEPMACDGLRTICIAYRDFSAIQepdwdNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNI 709
Cdd:cd01431    70 KIEKAQEESAREGLRVLALAYREFDPET-----SKEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNP 144
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  710 NTARAIAAKCGIIQPGEDFLCLEgkefnrrirnEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDSTtgeqrQVV 789
Cdd:cd01431   145 LTAIAIAREIGIDTKASGVILGE----------EADEMSEEELLDLIAKVAVFARVTPEQKLRIVKALQARG-----EVV 209
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  790 AVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFT 869
Cdd:cd01431   210 AMTGDGVNDAPALKQADVGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIAL 289
                         410       420       430
                  ....*....|....*....|....*....|
gi 569010236  870 GACITQDSPLKAVQMLWVNLIMDTFASLAL 899
Cdd:cd01431   290 ALFLGGPLPLLAFQILWINLVTDLIPALAL 319
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
79-936 5.02e-97

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 324.40  E-value: 5.02e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   79 EKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLsfyappgeeseacgnvsggaedeGEAEagwiEGA 158
Cdd:cd07538     8 RRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVL-----------------------GDPR----EGL 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  159 AILLSVICVVLVTAFNDWSKEKQFRGLqsRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLK 238
Cdd:cd07538    61 ILLIFVVVIIAIEVVQEWRTERALEAL--KNLSSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLENDDLG 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  239 IDESSLTGESDHVRKSAD----------KDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLgaggeeeekkdkkgkq 308
Cdd:cd07538   139 VDESTLTGESVPVWKRIDgkamsapggwDKNFCYAGTLVVRGRGVAKVEATGSRTELGKIGKSL---------------- 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  309 qdGAMDSSQTRAKKQdgavamemqplksaeggemeerekkkanvpkkeksvlQGKLTKLavqIGKAGLVMSAITVIilvL 388
Cdd:cd07538   203 --AEMDDEPTPLQKQ-------------------------------------TGRLVKL---CALAALVFCALIVA---V 237
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  389 YFVIETFVVDGrvwlaectpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNAT 468
Cdd:cd07538   238 YGVTRGDWIQA------------------ILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGSIT 299
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  469 AICSDKTGTLTTNRMTVVQSYLgdthykeipapsaltpkildllvhaisinsayttkilppekegalprqvgnktecall 548
Cdd:cd07538   300 VLCVDKTGTLTKNQMEVVELTS---------------------------------------------------------- 321
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  549 gfvldlkrdfqPVREqipedqlykvYTFNSVRKSMSTVIRMPDGGFrLFSKGASEILLKKCTnilnsngelrgFRPRDRD 628
Cdd:cd07538   322 -----------LVRE----------YPLRPELRMMGQVWKRPEGAF-AAAKGSPEAIIRLCR-----------LNPDEKA 368
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  629 DMVKKIIEpMACDGLRTICIAYRDFSAIQEPD--WDNENEVVGdltciaVVGIEDPVRPEVPEAIRKCQRAGITVRMVTG 706
Cdd:cd07538   369 AIEDAVSE-MAGEGLRVLAVAACRIDESFLPDdlEDAVFIFVG------LIGLADPLREDVPEAVRICCEAGIRVVMITG 441
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  707 DNINTARAIAAKCGI-----IQPGEDFLCLEGKEFNRRIRNekgeieqerldkvwpkLRVLARSSPTDKHTLVKGIidST 781
Cdd:cd07538   442 DNPATAKAIAKQIGLdntdnVITGQELDAMSDEELAEKVRD----------------VNIFARVVPEQKLRIVQAF--KA 503
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  782 TGEqrqVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNV 861
Cdd:cd07538   504 NGE---IVAMTGDGVNDAPALKAAHIGIAMGKRGTDVAREASDIVLLDDNFSSIVSTIRLGRRIYDNLKKAITYVFAIHV 580
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569010236  862 VAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISrtmmKNILGHAVYQ 936
Cdd:cd07538   581 PIAGLALLPPLLGLPPLLFPVHVVLLELIIDPTCSIVFEAEPAERDIMRRPPRPPDEPLFG----PRLVIKAILQ 651
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
159-946 9.60e-93

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 319.30  E-value: 9.60e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  159 AILLSVicVVLVTAFNDWSKEKQfrglQSRIEQE------QKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLI 232
Cdd:cd02608    72 GIVLAA--VVIVTGCFSYYQEAK----SSKIMDSfknmvpQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRII 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  233 QGNDLKIDESSLTGESDHVRKSAD---KDPM------LLSgTHVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkd 303
Cdd:cd02608   146 SAHGCKVDNSSLTGESEPQTRSPEfthENPLetkniaFFS-TNCVEGTARGIVINTGDRTVMGRIATL------------ 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  304 kkgkqqdgamdssqtrakkqdgavamemqplksAEGGEMEErekkkanvpkkeksvlqgklTKLAVQIGKAGLVMSAITV 383
Cdd:cd02608   213 ---------------------------------ASGLEVGK--------------------TPIAREIEHFIHIITGVAV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  384 IILVLYFVIEtfVVDGRVWLAECtpvyvqyfvkFFIIGVtvlVVA-VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACE 462
Cdd:cd02608   240 FLGVSFFILS--LILGYTWLEAV----------IFLIGI---IVAnVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVE 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  463 TMGNATAICSDKTGTLTTNRMTVV----------------QSylGDTHYKEIPAPSALTpKILDLlvhaisINSAyttKI 526
Cdd:cd02608   305 TLGSTSTICSDKTGTLTQNRMTVAhmwfdnqiheadttedQS--GASFDKSSATWLALS-RIAGL------CNRA---EF 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  527 LPPEKEGALPRQV--GNKTECALLGF-------VLDLKRDFQPVREqIPedqlykvytFNSVRK---SMSTVIRMPDGGF 594
Cdd:cd02608   373 KAGQENVPILKRDvnGDASESALLKCielscgsVMEMRERNPKVAE-IP---------FNSTNKyqlSIHENEDPGDPRY 442
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  595 RLFSKGASEILLKKCTNILNSNGELrgfrprDRDDMVKKIIEP--MACDGLRTICIAYRDF--SAIQEP-----DWDNEN 665
Cdd:cd02608   443 LLVMKGAPERILDRCSTILINGKEQ------PLDEEMKEAFQNayLELGGLGERVLGFCHLylPDDKFPegfkfDTDEVN 516
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  666 EVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIqpgedflclegkefnrrirnekg 745
Cdd:cd02608   517 FPTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGII----------------------- 573
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  746 eieqerldkvwpklrVLARSSPTDKHTLVKGIidsttgeQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS 823
Cdd:cd02608   574 ---------------VFARTSPQQKLIIVEGC-------QRQgaIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAA 631
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  824 DIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNvVAVIVAFTgACITQDSPLK--AVQMLWVNLIMDTFASLALAT 901
Cdd:cd02608   632 DMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN-IPEITPFL-IFIIANIPLPlgTITILCIDLGTDMVPAISLAY 709
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|
gi 569010236  902 EPPTESLLLRKPygRDkPLISRTMMKNILGHAVYQLTII-----FTLLFV 946
Cdd:cd02608   710 EKAESDIMKRQP--RN-PKTDKLVNERLISMAYGQIGMIqalagFFTYFV 756
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
158-902 8.09e-91

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 306.65  E-value: 8.09e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  158 AAILLSVICV-VLVTAFNDWSKEKQFRGLqsRIEQEQKFTVIR--NGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQG 234
Cdd:cd07539    60 AVLIVGVLTVnAVIGGVQRLRAERALAAL--LAQQQQPARVVRapAGRTQTVPAESLVPGDVIELRAGEVVPADARLLEA 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  235 NDLKIDESSLTGESDHVRKS---------ADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGaggeeeekkdkk 305
Cdd:cd07539   138 DDLEVDESALTGESLPVDKQvaptpgaplADRACMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLVA------------ 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  306 gkqqdgamdssqtrakkqdgavamemqPLKSAEGGEMEEREkkkanvpkkeksvlqgkLTKLAVQIGKAGlvMSAITVII 385
Cdd:cd07539   206 ---------------------------PVETATGVQAQLRE-----------------LTSQLLPLSLGG--GAAVTGLG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  386 LVLYFVIETFVVDGrvwlaectpvyvqyfvkffiigVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMG 465
Cdd:cd07539   240 LLRGAPLRQAVADG----------------------VSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALG 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  466 NATAICSDKTGTLTTNRMTVVQsylgdthykeipapsaltpkildllvhaisinsayttkilppekegalprqvgnktec 545
Cdd:cd07539   298 RVDTICFDKTGTLTENRLRVVQ---------------------------------------------------------- 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  546 allgfvldlkrdFQPVREQIPedqlykvytFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILnSNGELRGFRPR 625
Cdd:cd07539   320 ------------VRPPLAELP---------FESSRGYAAAIGRTGGGIPLLAVKGAPEVVLPRCDRRM-TGGQVVPLTEA 377
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  626 DRDdMVKKIIEPMACDGLRTICIAYRDFSAIQEPDWDNeneVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVT 705
Cdd:cd07539   378 DRQ-AIEEVNELLAGQGLRVLAVAYRTLDAGTTHAVEA---VVDDLELLGLLGLADTARPGAAALIAALHDAGIDVVMIT 453
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  706 GDNINTARAIAAKCGIIQPGEdflCLEGKEFNRrirnekgeIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDSTTgeq 785
Cdd:cd07539   454 GDHPITARAIAKELGLPRDAE---VVTGAELDA--------LDEEALTGLVADIDVFARVSPEQKLQIVQALQAAGR--- 519
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  786 rqVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVI 865
Cdd:cd07539   520 --VVAMTGDGANDAAAIRAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQNVRDAVHVLLGGNLGEVM 597
                         730       740       750
                  ....*....|....*....|....*....|....*..
gi 569010236  866 VAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATE 902
Cdd:cd07539   598 FTLIGTAIGGGAPLNTRQLLLVNLLTDMFPALALAVE 634
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
193-935 2.01e-88

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 309.03  E-value: 2.01e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   193 QKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKSAD---KDPM-----LLSG 264
Cdd:TIGR01106  141 QQALVIRDGEKMSINAEQVVVGDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEfthENPLetrniAFFS 220
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   265 THVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdkkgkqqdgamdssqtrakkqdgavamemqplksAEGgemee 344
Cdd:TIGR01106  221 TNCVEGTARGIVVNTGDRTVMGRIASL---------------------------------------------ASG----- 250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   345 rekkkanvpkkeksvLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIEtfVVDGRVWLAECtpvyvqyfvkFFIIGVtv 424
Cdd:TIGR01106  251 ---------------LENGKTPIAIEIEHFIHIITGVAVFLGVSFFILS--LILGYTWLEAV----------IFLIGI-- 301
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   425 LVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYL-------------- 490
Cdd:TIGR01106  302 IVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFdnqiheadttedqs 381
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   491 GDTHYKEIPAPSALTpKILDLLVHAIsinsayttkiLPPEKEGA--LPRQV-GNKTECALLGF-------VLDLKRDFQP 560
Cdd:TIGR01106  382 GVSFDKSSATWLALS-RIAGLCNRAV----------FKAGQENVpiLKRAVaGDASESALLKCielclgsVMEMRERNPK 450
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   561 VREqIPedqlykvytFNSVRKSMSTVIRMPDGG---FRLFSKGASEILLKKCTNILNSNGELrgfrPRDRDdmVKKIIEP 637
Cdd:TIGR01106  451 VVE-IP---------FNSTNKYQLSIHENEDPRdprHLLVMKGAPERILERCSSILIHGKEQ----PLDEE--LKEAFQN 514
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   638 --MACDGL--RTICIAYRDFSAIQEP-----DWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDN 708
Cdd:TIGR01106  515 ayLELGGLgeRVLGFCHLYLPDEQFPegfqfDTDDVNFPTDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDH 594
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   709 INTARAIAAKCGIIQPG----EDF---LCLEGKEFNRRIRN-------EKGEIEQERLDKVwpkLR-----VLARSSPTD 769
Cdd:TIGR01106  595 PITAKAIAKGVGIISEGnetvEDIaarLNIPVSQVNPRDAKacvvhgsDLKDMTSEQLDEI---LKyhteiVFARTSPQQ 671
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   770 KHTLVKGIidsttgeQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYD 847
Cdd:TIGR01106  672 KLIIVEGC-------QRQgaIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFD 744
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   848 SISKFLQFQLTVNV--VAVIVAFTGACITQdsPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYG--RDK----P 919
Cdd:TIGR01106  745 NLKKSIAYTLTSNIpeITPFLIFIIANIPL--PLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNpkTDKlvneR 822
                          810       820
                   ....*....|....*....|.
gi 569010236   920 LISRT-----MMKNILGHAVY 935
Cdd:TIGR01106  823 LISMAygqigMIQALGGFFTY 843
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
63-957 6.45e-84

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 296.92  E-value: 6.45e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236    63 LKTSPTEGLADNtnDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSfyappgeeseacgnvsg 142
Cdd:TIGR01523   19 IGTSIPEGLTHD--EAQHRLKEVGENRLEADSGIDAKAMLLHQVCNAMCMVLIIAAAISFAMH----------------- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   143 gaedegeaeaGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKftVIRNGQLLQVPVAALVVGDIAQVKYG 222
Cdd:TIGR01523   80 ----------DWIEGGVISAIIALNILIGFIQEYKAEKTMDSLKNLASPMAH--VIRNGKSDAIDSHDLVPGDICLLKTG 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   223 DLLPADGVLIQGNDLKIDESSLTGESDHVRKSA-------------DKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIF 289
Cdd:TIGR01523  148 DTIPADLRLIETKNFDTDEALLTGESLPVIKDAhatfgkeedtpigDRINLAFSSSAVTKGRAKGICIATALNSEIGAIA 227
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   290 TLLgaggeeeekkdkkgkqqdgamdssqtrakKQDGAVamemqpLKSAEGGEMEEREKKKANVPKKEKSV---------- 359
Cdd:TIGR01523  228 AGL-----------------------------QGDGGL------FQRPEKDDPNKRRKLNKWILKVTKKVtgaflglnvg 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   360 --LQGKLTKLAVqigkaglVMSAITVIILVLYFVIETFVVDGRVwlaectpvyvqyfvkfFIIGVTVLVVAVPEGLPLAV 437
Cdd:TIGR01523  273 tpLHRKLSKLAV-------ILFCIAIIFAIIVMAAHKFDVDKEV----------------AIYAICLAISIIPESLIAVL 329
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   438 TISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIP-APSALTPK------ILD 510
Cdd:TIGR01523  330 SITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWIPRFGTISIDnSDDAFNPNegnvsgIPR 409
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   511 LLVHAISINSAYTTKILPPEK----EGALPRQV--------------------------------GNKTECALLGFV--L 552
Cdd:TIGR01523  410 FSPYEYSHNEAADQDILKEFKdelkEIDLPEDIdmdlfiklletaalaniatvfkddatdcwkahGDPTEIAIHVFAkkF 489
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   553 DLKRDFQPVREQI--------------------PEDQLYKVYTFNSVRKSMSTVIRMPDG-GFRLFSKGASEILLKKCTN 611
Cdd:TIGR01523  490 DLPHNALTGEEDLlksnendqsslsqhnekpgsAQFEFIAEFPFDSEIKRMASIYEDNHGeTYNIYAKGAFERIIECCSS 569
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   612 ILNSNG-ELRGFRPRDRDdMVKKIIEPMACDGLRTICIAYRDFSAIQEPDWDNENEVV------GDLTCIAVVGIEDPVR 684
Cdd:TIGR01523  570 SNGKDGvKISPLEDCDRE-LIIANMESLAAEGLRVLAFASKSFDKADNNDDQLKNETLnrataeSDLEFLGLIGIYDPPR 648
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   685 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGII--------QPGEDFLCLEGKEFNrrirnekgEIEQERLDKVW 756
Cdd:TIGR01523  649 NESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGIIppnfihdrDEIMDSMVMTGSQFD--------ALSDEEVDDLK 720
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   757 PKLRVLARSSPTDKHTLVKGIidsttGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIV 836
Cdd:TIGR01523  721 ALCLVIARCAPQTKVKMIEAL-----HRRKAFCAMTGDGVNDSPSLKMANVGIAMGINGSDVAKDASDIVLSDDNFASIL 795
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   837 KAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS-----PLKAVQMLWVNLIMDTFASLALATEPPTESLLLR 911
Cdd:TIGR01523  796 NAIEEGRRMFDNIMKFVLHLLAENVAEAILLIIGLAFRDENgksvfPLSPVEILWCIMITSCFPAMGLGLEKAAPDLMDR 875
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....*.
gi 569010236   912 KPYGRDKPLISRTMMKNILGHAVYqLTIIFTLLFVGELfFDIDSGR 957
Cdd:TIGR01523  876 LPHDNEVGIFQKELIIDMFAYGFF-LGGSCLASFTGIL-YGFGSGN 919
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
75-1051 2.70e-78

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 275.26  E-value: 2.70e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   75 TNDLEKRRQIYGQNFIPPKQP---KTFLQLVWEALQdvtlIILEVAAIVSLGLsfyappgeeseacgnvsggaedegeae 151
Cdd:cd02076     4 SEEAAKRLKEYGPNELPEKKEnpiLKFLSFFWGPIP----WMLEAAAILAAAL--------------------------- 52
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  152 AGWIEGAAILLsvicVVLVTAFNDWSKEKQFRGLQSRIEQ--EQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADG 229
Cdd:cd02076    53 GDWVDFAIILL----LLLINAGIGFIEERQAGNAVAALKKslAPKARVLRDGQWQEIDAKELVPGDIVSLKIGDIVPADA 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  230 VLIQGNDLKIDESSLTGESDHVRKSadKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGiiftllgaggeeeekkdkkgkqq 309
Cdd:cd02076   129 RLLTGDALQVDQSALTGESLPVTKH--PGDEAYSGSIVKQGEMLAVVTATGSNTFFG----------------------- 183
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  310 dgamdssqtrakkqdgavamemqplksaeggemeerekKKANVPKKEKSvlQGKLTKLAVQIGKAGLVMSAITV--IILV 387
Cdd:cd02076   184 --------------------------------------KTAALVASAEE--QGHLQKVLNKIGNFLILLALILVliIVIV 223
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  388 LYFVIETFVvdgrvwlaectpvyvqYFVKFFIIgvtVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNA 467
Cdd:cd02076   224 ALYRHDPFL----------------EILQFVLV---LLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEELAGV 284
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  468 TAICSDKTGTLTTNRMTVVQSYLGDTHYKEipapsaltpkilDLLVHAisinsAYTTKilpPEKEGALPRqvgnktecAL 547
Cdd:cd02076   285 DILCSDKTGTLTLNKLSLDEPYSLEGDGKD------------ELLLLA-----ALASD---TENPDAIDT--------AI 336
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  548 LGFVLDLKRDfqpvreqIPEDQLYKVYTFNSVRK-SMSTVIRmPDGGFRLFSKGASEILLKKCTNilnsngelrgfrPRD 626
Cdd:cd02076   337 LNALDDYKPD-------LAGYKQLKFTPFDPVDKrTEATVED-PDGERFKVTKGAPQVILELVGN------------DEA 396
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  627 RDDMVKKIIEPMACDGLRTICIAYRDfsaiQEPDWdnenEVVGDLTCIavvgieDPVRPEVPEAIRKCQRAGITVRMVTG 706
Cdd:cd02076   397 IRQAVEEKIDELASRGYRSLGVARKE----DGGRW----ELLGLLPLF------DPPRPDSKATIARAKELGVRVKMITG 462
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  707 DNINTARAIAAKCGI---IQPGEDFLCLEGKefnrriRNEKGEIEQERLDKVwpklRVLARSSPTDKHTLVKGIidsttg 783
Cdd:cd02076   463 DQLAIAKETARQLGMgtnILSAERLKLGGGG------GGMPGSELIEFIEDA----DGFAEVFPEHKYRIVEAL------ 526
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  784 EQR-QVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVnVV 862
Cdd:cd02076   527 QQRgHLVGMTGDGVNDAPALKKADVGIAVSGA-TDAARAAADIVLTAPGLSVIIDAIKTSRQIFQRMKSYVIYRIAE-TL 604
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  863 AVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEppteslllRKPYgRDKPLISRtmMKNILGHAVYqLTIIFT 942
Cdd:cd02076   605 RILVFFTLGILILNFYPLPLIMIVLIAILNDGATLTIAYD--------NVPP-SPRPVRWN--MPELLGIATV-LGVVLT 672
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  943 LLFVGELFFDIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDG-IFSNPIFCTIVLGTFgiqivIV 1021
Cdd:cd02076   673 ISSFLLLWLLDDQGWFEDIVLSAGELQTILYLQLSISGHLTIFVTRTRGPFWRPRPSpLLFIAVVLTQILATL-----LA 747
                         970       980       990
                  ....*....|....*....|....*....|
gi 569010236 1022 QFGgkPFSCSPLSteqWLWCLFVGVGELVW 1051
Cdd:cd02076   748 VYG--WFMFAGIG---WGWALLVWIYALVW 772
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
74-913 2.70e-77

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 272.20  E-value: 2.70e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   74 NTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEESeacgnvsggaedegeaeag 153
Cdd:cd02077     3 TNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLAPGEFD------------------- 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  154 wIEGAAILLS-VICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVIRNGQL-LQVPVAALVVGDIAQVKYGDLLPADGVL 231
Cdd:cd02077    64 -LVGALIILLmVLISGLLDFIQEIRSLKAAEKLKKMVKN--TATVIRDGSKyMEIPIDELVPGDIVYLSAGDMIPADVRI 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  232 IQGNDLKIDESSLTGESDHVRKSA-----------DKDPMLLSGTHVMEGSGRMVVTAVGVNsqtgiifTLLGAggeeee 300
Cdd:cd02077   141 IQSKDLFVSQSSLTGESEPVEKHAtakktkdesilELENICFMGTNVVSGSALAVVIATGND-------TYFGS------ 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  301 kkdkkgkqqdgamdssqtrakkqdgavamemqplksaeggeMEEREKKKANVPKKEKSVlqGKLTKLavqigkaglVMSA 380
Cdd:cd02077   208 -----------------------------------------IAKSITEKRPETSFDKGI--NKVSKL---------LIRF 235
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  381 ITVIILVLYFVIetfVVDGRVWLaectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDA 460
Cdd:cd02077   236 MLVMVPVVFLIN---GLTKGDWL------------EALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNA 300
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  461 CETMGNATAICSDKTGTLTTNRMTVVQSYlgDTHYKEipapsalTPKILDLLVhaisINSAYTTKILPPekegaLPRQVG 540
Cdd:cd02077   301 IQNFGAMDILCTDKTGTLTQDKIVLERHL--DVNGKE-------SERVLRLAY----LNSYFQTGLKNL-----LDKAII 362
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  541 NKTECALLGFvldLKRDFQPVREqIPedqlykvytFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNIlNSNGELR 620
Cdd:cd02077   363 DHAEEANANG---LIQDYTKIDE-IP---------FDFERRRMSVVVKDNDGKHLLITKGAVEEILNVCTHV-EVNGEVV 428
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  621 GFRPRDRdDMVKKIIEPMACDGLRTICIAYRdfsAIQEPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGIT 700
Cdd:cd02077   429 PLTDTLR-EKILAQVEELNREGLRVLAIAYK---KLPAPEGEYSVKDEKELILIGFLAFLDPPKESAAQAIKALKKNGVN 504
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  701 VRMVTGDNINTARAIAAKCGiIQPGEdflCLEGKEFNrrirnekgEIEQERLDKVWPKLRVLARSSPTDKHTlvkgIIDS 780
Cdd:cd02077   505 VKILTGDNEIVTKAICKQVG-LDINR---VLTGSEIE--------ALSDEELAKIVEETNIFAKLSPLQKAR----IIQA 568
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  781 TTgEQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVN 860
Cdd:cd02077   569 LK-KNGHVVGFMGDGINDAPALRQADVGISVDSA-VDIAKEAADIILLEKDLMVLEEGVIEGRKTFGNILKYIKMTASSN 646
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 569010236  861 ---VVAVIVAftgACITQDSPLKAVQMLWVNLIMDtFASLALATEPPTESlLLRKP 913
Cdd:cd02077   647 fgnVFSVLVA---SAFLPFLPMLPIQLLLQNLLYD-FSQLAIPFDNVDEE-FLKKP 697
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
194-938 6.17e-66

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 236.41  E-value: 6.17e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  194 KFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKSADKDpmLLSGTHVMEGSGR 273
Cdd:cd02609    93 KVTVIRDGQEVKIPPEELVLDDILILKPGEQIPADGEVVEGGGLEVDESLLTGESDLIPKKAGDK--LLSGSFVVSGAAY 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  274 MVVTAVGVNSQTgiiftllgaggeeeekkdkkgkqqdgamdSSQTRAKKQDgavamemqplksaeggemeerekkkanvp 353
Cdd:cd02609   171 ARVTAVGAESYA-----------------------------AKLTLEAKKH----------------------------- 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  354 KKEKSVLQGKLTKLAVqigkaglVMSAITVIILVLYFViETFVVDGRVWLAEctpvyvqyfvkffIIG-VTVLVVAVPEG 432
Cdd:cd02609   193 KLINSELLNSINKILK-------FTSFIIIPLGLLLFV-EALFRRGGGWRQA-------------VVStVAALLGMIPEG 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  433 LPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIpapsalTPKILDLL 512
Cdd:cd02609   252 LVLLTSVALAVGAIRLAKKKVLVQELYSIETLARVDVLCLDKTGTITEGKMKVERVEPLDEANEAE------AAAALAAF 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  513 VHAISINsayttkilppekegalprqvgNKTECALLGFVLDLKRdfQPVREQIPedqlykvytFNSVRKSMStvIRMPDG 592
Cdd:cd02609   326 VAASEDN---------------------NATMQAIRAAFFGNNR--FEVTSIIP---------FSSARKWSA--VEFRDG 371
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  593 GfrLFSKGASEILLkkctnilnsngelrgfrpRDRDDMVKKIIEPMACDGLRTICIAYrdfsAIQEPDWDnenEVVGDLT 672
Cdd:cd02609   372 G--TWVLGAPEVLL------------------GDLPSEVLSRVNELAAQGYRVLLLAR----SAGALTHE---QLPVGLE 424
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  673 CIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGiiqpgedflcLEGKEFNRRIRNEKGEieqERL 752
Cdd:cd02609   425 PLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAG----------LEGAESYIDASTLTTD---EEL 491
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  753 DKVWPKLRVLARSSPTDKHTLVKgiidsTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNF 832
Cdd:cd02609   492 AEAVENYTVFGRVTPEQKRQLVQ-----ALQALGHTVAMTGDGVNDVLALKEADCSIAMA-SGSDATRQVAQVVLLDSDF 565
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  833 TSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESlllrk 912
Cdd:cd02609   566 SALPDVVFEGRRVVNNIERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEPNKRR----- 640
                         730       740
                  ....*....|....*....|....*.
gi 569010236  913 pygrdkplISRTMMKNILGHAVYQLT 938
Cdd:cd02609   641 --------IEGGFLRRVLTKALPPLN 658
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
196-870 4.38e-57

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 211.54  E-value: 4.38e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  196 TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLkIDESSLTGESDHVRKSADkDPmLLSGTHVMEGSGRMV 275
Cdd:COG2217   216 RVLRDGEEVEVPVEELRVGDRVLVRPGERIPVDGVVLEGESS-VDESMLTGESLPVEKTPG-DE-VFAGTINLDGSLRVR 292
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  276 VTAVGVNSQ-TGIIftllgaggeeeekkdkkgkqqdgamdssqtrakkqdgavamEMqplksaeggeMEEREKKKAnvpk 354
Cdd:COG2217   293 VTKVGSDTTlARII-----------------------------------------RL----------VEEAQSSKA---- 317
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  355 keksvlqgKLTKLAVQIgkaglvmSAI-TVIILVLYFVieTFVVdgrvWLaectpVYVQYFVKFFIIGVTVLVVAVPEGL 433
Cdd:COG2217   318 --------PIQRLADRI-------ARYfVPAVLAIAAL--TFLV----WL-----LFGGDFSTALYRAVAVLVIACPCAL 371
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  434 PLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSylgdthykeIPAPSALTPKILDLLV 513
Cdd:COG2217   372 GLATPTAIMVGTGRAARRGILIKGGEALERLAKVDTVVFDKTGTLTEGKPEVTDV---------VPLDGLDEDELLALAA 442
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  514 -------HAIS--INSAYttkilppEKEGALPRQVGNKTECALLGfvldlkrdfqpVREQIpEDQLYKVytfnsvrksms 584
Cdd:COG2217   443 aleqgseHPLAraIVAAA-------KERGLELPEVEDFEAIPGKG-----------VEATV-DGKRVLV----------- 492
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  585 tvirmpdGGFRLFSKGASEIllkkctnilnsngelrgfrprdrDDMVKKIIEPMACDGLRTICIAyrdfsaiqepdWDNE 664
Cdd:COG2217   493 -------GSPRLLEEEGIDL-----------------------PEALEERAEELEAEGKTVVYVA-----------VDGR 531
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  665 nevvgdltCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIqpgedflclegkefnrrirnek 744
Cdd:COG2217   532 --------LLGLIALADTLRPEAAEAIAALKALGIRVVMLTGDNERTAEAVARELGID---------------------- 581
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  745 geieqerldkvwpklRVLARSSPTDKHTLVKGIIdsttgEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASD 824
Cdd:COG2217   582 ---------------EVRAEVLPEDKAAAVRELQ-----AQGKKVAMVGDGINDAPALAAADVGIAMG-SGTDVAIEAAD 640
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*.
gi 569010236  825 IILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 870
Cdd:COG2217   641 IVLMRDDLRGVPDAIRLSRATMRIIRQNLFWAFGYNVIGIPLAAGG 686
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
175-870 2.02e-51

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 191.31  E-value: 2.02e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   175 DWSKEKQFRGLQSRIEQ--EQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLkIDESSLTGESDHVR 252
Cdd:TIGR01525   36 ERAKSRASDALSALLALapSTARVLQGDGSEEEVPVEELQVGDIVIVRPGERIPVDGVVISGESE-VDESALTGESMPVE 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   253 KSADKDpmLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdkkgkqqdgamdssqtrakkqdgavamemq 332
Cdd:TIGR01525  115 KKEGDE--VFAGTINGDGSLTIRVTKLGEDSTLAQIVEL----------------------------------------- 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   333 plksaeggeMEEREKKKAnvpkkeksvlqgKLTKLAVQIgkAGLVMSAITVIILVLYFVIETFVVDGRVWlaectpvyvq 412
Cdd:TIGR01525  152 ---------VEEAQSSKA------------PIQRLADRI--ASYYVPAVLAIALLTFVVWLALGALWREA---------- 198
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   413 yfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQ-SYLG 491
Cdd:TIGR01525  199 -----LYRALTVLVVACPCALGLATPVAILVAIGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVDiEPLD 273
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   492 DTHYKEIPAPSALTPKILDllvHAISInsayttkilppekegALPRQVgNKTECALLGfvldlkRDFQPVreqipedqly 571
Cdd:TIGR01525  274 DASEEELLALAAALEQSSS---HPLAR---------------AIVRYA-KERGLELPP------EDVEEV---------- 318
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   572 kvytfnsvrksmstvirmPDGGFRLFSKGASEILLKKCTNILNSngELRGFRPRDRDDMVKKIIEpmacdGLRTICIAYR 651
Cdd:TIGR01525  319 ------------------PGKGVEATVDGGREVRIGNPRFLGNR--ELAIEPISASPDLLNEGES-----QGKTVVFVAV 373
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   652 DfsaiqepdwdneNEVVGdltciaVVGIEDPVRPEVPEAIRKCQRAG-ITVRMVTGDNINTARAIAAKCGIiqpgedflc 730
Cdd:TIGR01525  374 D------------GELLG------VIALRDQLRPEAKEAIAALKRAGgIKLVMLTGDNRSAAEAVAAELGI--------- 426
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   731 legkefnrrirnekgeiEQErldkvwpklrVLARSSPTDKHTLVKGIIdsttgEQRQVVAVTGDGTNDGPALKKADVGFA 810
Cdd:TIGR01525  427 -----------------DDE----------VHAELLPEDKLAIVKKLQ-----EEGGPVAMVGDGINDAPALAAADVGIA 474
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   811 MGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 870
Cdd:TIGR01525  475 MG-SGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKQNLAWALGYNLVAIPLAAGG 533
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
877-1055 2.34e-50

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 175.89  E-value: 2.34e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   877 SPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLTIIFTLLFVGELFFDIDSG 956
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   957 RNAplhsppsehYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFSNPIFCTIVLGTFGIQIVIVQ--FGGKPFSCSPLS 1034
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 569010236  1035 TEQWLWCLFVGVGELVWGQVI 1055
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
55-867 4.93e-50

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 192.59  E-value: 4.93e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   55 DVSGLCRRLKTSPtEGLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSlglsfYAppgees 134
Cdd:PRK10517   53 PEEELWKTFDTHP-EGL--NEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNPFNILLTILGAIS-----YA------ 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  135 eacgnvsggAEDEGeaeagwiegAAILLSVIcVVLVTAFNDWSKEKQFRG---LQSRIEQeqKFTVIRNG------QLLQ 205
Cdd:PRK10517  119 ---------TEDLF---------AAGVIALM-VAISTLLNFIQEARSTKAadaLKAMVSN--TATVLRVIndkgenGWLE 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  206 VPVAALVVGDIAQVKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKSA-----------DKDPMLLSGTHVMEGSGRM 274
Cdd:PRK10517  178 IPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKFAttrqpehsnplECDTLCFMGTNVVSGTAQA 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  275 VVTAVGVNsqtgiifTLLGAGGeeeekkdkkgkqqdgamdssqTRAKKQDGAVamemqplksaeggemeerekkkanvpk 354
Cdd:PRK10517  258 VVIATGAN-------TWFGQLA---------------------GRVSEQDSEP--------------------------- 282
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  355 kekSVLQGKLTKLAVQIGKAGLVMSAItviilVLYfvIETFVvDGRVWLAectpvyvqyfvkfFIIGVTVLVVAVPEGLP 434
Cdd:PRK10517  283 ---NAFQQGISRVSWLLIRFMLVMAPV-----VLL--INGYT-KGDWWEA-------------ALFALSVAVGLTPEMLP 338
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  435 LAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQsylgdtHYKEIPAPSaltpkilDLLVH 514
Cdd:PRK10517  339 MIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIVLEN------HTDISGKTS-------ERVLH 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  515 AISINSAYTTKIlppekEGALPRQVgnkTECALLGFVLDLKRDFQPVREqIPedqlykvytFNSVRKSMSTVIRMPDGGF 594
Cdd:PRK10517  406 SAWLNSHYQTGL-----KNLLDTAV---LEGVDEESARSLASRWQKIDE-IP---------FDFERRRMSVVVAENTEHH 467
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  595 RLFSKGASEILLKKCTNILNsNGELRGFRPrDRDDMVKKIIEPMACDGLRTICIAYRDFSAIQEpDWDNENEvvGDLTCI 674
Cdd:PRK10517  468 QLICKGALEEILNVCSQVRH-NGEIVPLDD-IMLRRIKRVTDTLNRQGLRVVAVATKYLPAREG-DYQRADE--SDLILE 542
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  675 AVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNintaRAIAAKcgiiqpgedfLCLE-GKEFNRRIRNekGEIEQ---E 750
Cdd:PRK10517  543 GYIAFLDPPKETTAPALKALKASGVTVKILTGDS----ELVAAK----------VCHEvGLDAGEVLIG--SDIETlsdD 606
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  751 RLDKVWPKLRVLARSSPTDKHTLVKGIIDsttgeQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDD 830
Cdd:PRK10517  607 ELANLAERTTLFARLTPMHKERIVTLLKR-----EGHVVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADIILLEK 680
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|..
gi 569010236  831 NFTSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVA 867
Cdd:PRK10517  681 SLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
196-839 4.15e-47

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 179.98  E-value: 4.15e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  196 TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLkIDESSLTGESDHVRKSADkDPmLLSGTHVMEGSGRMV 275
Cdd:cd02094   142 RVIRDGKEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVEGESS-VDESMLTGESLPVEKKPG-DK-VIGGTINGNGSLLVR 218
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  276 VTAVGVNsqtgiifTLLgaggeeeekkdkkgkqqdgamdsSQTrakkqdgaVAMemqplksaeggeMEEREKKKANVpkk 355
Cdd:cd02094   219 ATRVGAD-------TTL-----------------------AQI--------IRL------------VEEAQGSKAPI--- 245
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  356 eksvlqgklTKLAVQIgkaglvmSAITV-IILVLyfVIETFVVdgrvWLAECTPVYVQYFVKFFIigvTVLVVAVPEGLP 434
Cdd:cd02094   246 ---------QRLADRV-------SGVFVpVVIAI--AILTFLV----WLLLGPEPALTFALVAAV---AVLVIACPCALG 300
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  435 LAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqsylgdthyKEIPAPSALTPKILDLlVH 514
Cdd:cd02094   301 LATPTAIMVGTGRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVT---------DVVPLPGDDEDELLRL-AA 370
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  515 AISINSayttkilppekEGALPRQVgnKTECALLGFVLDLKRDFQPVreqipedqlykvytfnsVRKSMSTVIrmpdGGF 594
Cdd:cd02094   371 SLEQGS-----------EHPLAKAI--VAAAKEKGLELPEVEDFEAI-----------------PGKGVRGTV----DGR 416
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  595 RLFSkGASEILLKKCTNILNSNGElrgfrprdrddmvkkiIEPMACDGLRTICIAYrdfsaiqepdwdnENEVVGdltci 674
Cdd:cd02094   417 RVLV-GNRRLMEENGIDLSALEAE----------------ALALEEEGKTVVLVAV-------------DGELAG----- 461
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  675 aVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgedflclegkefnrrirnekgeieqerlDK 754
Cdd:cd02094   462 -LIAVADPLKPDAAEAIEALKKMGIKVVMLTGDNRRTARAIAKELGI-------------------------------DE 509
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  755 VWpklrvlARSSPTDKHTLVKGIidsttGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTS 834
Cdd:cd02094   510 VI------AEVLPEDKAEKVKKL-----QAQGKKVAMVGDGINDAPALAQADVGIAIG-SGTDVAIESADIVLMRGDLRG 577

                  ....*
gi 569010236  835 IVKAV 839
Cdd:cd02094   578 VVTAI 582
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
175-870 7.57e-47

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 178.95  E-value: 7.57e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  175 DWSKEKQFRGLQSRIEQEQKF-TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLkIDESSLTGESDHVRK 253
Cdd:cd02079   106 ERARSRARSALKALLSLAPETaTVLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS-VDESSLTGESLPVEK 184
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  254 SADkDPmLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdkkgkqqdgamdssqtrakkqdgavamemqp 333
Cdd:cd02079   185 GAG-DT-VFAGTINLNGPLTIEVTKTGEDTTLAKIIRL------------------------------------------ 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  334 lksaeggeMEEREKKKANVpkkeksvlQGKLTKLAVQIGKAGLVMSAITVIILVLYFVietfVVDGRVWLAectpvyvqy 413
Cdd:cd02079   221 --------VEEAQSSKPPL--------QRLADRFARYFTPAVLVLAALVFLFWPLVGG----PPSLALYRA--------- 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  414 fvkffiigVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVvqsylgdt 493
Cdd:cd02079   272 --------LAVLVVACPCALGLATPTAIVAGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEV-------- 335
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  494 hyKEIPAPSALTPKILDLLVHAIsinsayttkilppEKEGALPrqvgnktecalLGfvldlkrdfQPVREQIPEDqlykv 573
Cdd:cd02079   336 --TEIEPLEGFSEDELLALAAAL-------------EQHSEHP-----------LA---------RAIVEAAEEK----- 375
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  574 ytfnsvrksmsTVIRMPDGGFRLFS-KGASEILlkkctnilnSNGELRGFRPRD-RDDMVKKIIEPMACDGLRTICIAYR 651
Cdd:cd02079   376 -----------GLPPLEVEDVEEIPgKGISGEV---------DGREVLIGSLSFaEEEGLVEAADALSDAGKTSAVYVGR 435
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  652 DfsaiqepdwdneNEVVGdltciaVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgedflcl 731
Cdd:cd02079   436 D------------GKLVG------LFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGI---------- 487
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  732 egkefnrrirnekgeieqerldkvwpkLRVLARSSPTDKHTLVKGIidsttGEQRQVVAVTGDGTNDGPALKKADVGFAM 811
Cdd:cd02079   488 ---------------------------DEVHAGLLPEDKLAIVKAL-----QAEGGPVAMVGDGINDAPALAQADVGIAM 535
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 569010236  812 GiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 870
Cdd:cd02079   536 G-SGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKQNLAWALGYNAIALPLAALG 593
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
154-870 1.97e-44

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 170.20  E-value: 1.97e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   154 WIEGAAILLSVIcvvLVTAFNDWSKEKQFRGLQSRIEQE-QKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLI 232
Cdd:TIGR01512   18 YLEGALLLLLFS---IGETLEEYASGRARRALKALMELApDTARRLQGDSLEEVAVEELKVGDVVVVKPGERVPVDGEVL 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   233 QGNDLkIDESSLTGESDHVRKSADKDpmLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdkkgkqqdga 312
Cdd:TIGR01512   95 SGTSS-VDESALTGESVPVEKAPGDE--VFAGAINLDGVLTIEVTKLPADSTIAKIVNL--------------------- 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   313 mdssqtrakkqdgavamemqplksaeggeMEEREKKKAnvpkkeksvlqgKLTKLAVQIGK--AGLVMSAITVIILVLYF 390
Cdd:TIGR01512  151 -----------------------------VEEAQSRKA------------PTQRFIDRFARyyTPAVLAIALAAALVPPL 189
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   391 VietfvvdgRVWLaectpvyvqyFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAI 470
Cdd:TIGR01512  190 L--------GAGP----------FLEWIYRALVLLVVASPCALVISAPAAYLSAISAAARHGILIKGGAALEALAKIKTV 251
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   471 CSDKTGTLTTNRMTVVQSYLGDTH-----YKEIPAPSALTPKILdllvhAISINSAYTTKILPPEKEgalprqvgnktec 545
Cdd:TIGR01512  252 AFDKTGTLTTGKPKVTDVHPADGHsesevLRLAAAAEQGSTHPL-----ARAIVDYARARELAPPVE------------- 313
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   546 allgfvldlkrDFQPVreqipedqlykvytfnsvrksmstvirmPDGGFRLFSKGaseillkkctnilnsnGELRGFRPR 625
Cdd:TIGR01512  314 -----------DVEEV----------------------------PGEGVRAVVDG----------------GEVRIGNPR 338
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   626 DRDDMVKKIIEPMaCDGLRTICIAYRDfsaiqepdwdnenevvGDLtcIAVVGIEDPVRPEVPEAIRKCQRAGI-TVRMV 704
Cdd:TIGR01512  339 SLSEAVGASIAVP-ESAGKTIVLVARD----------------GTL--LGYIALSDELRPDAAEAIAELKALGIkRLVML 399
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   705 TGDNINTARAIAAKCGIIQpgedflclegkefnrrirnekgeieqerldkvwpklrVLARSSPTDKHTLVKGIIdsttgE 784
Cdd:TIGR01512  400 TGDRRAVAEAVARELGIDE-------------------------------------VHAELLPEDKLEIVKELR-----E 437
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   785 QRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAV 864
Cdd:TIGR01512  438 KAGPVAMVGDGINDAPALAAADVGIAMGASGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVIALGIILVLI 517

                   ....*.
gi 569010236   865 IVAFTG 870
Cdd:TIGR01512  518 LLALFG 523
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
161-941 1.23e-40

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 162.72  E-value: 1.23e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  161 LLSVICVVLVTA----FNDWSKEKQFRGLQSRieqeqKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGND 236
Cdd:cd02073    52 LLPLLFVLGVTAikegYEDIRRHKSDNEVNNR-----PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSE 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  237 LK----IDESSLTGESDH-VRKSADKDPMLLSGTHVMEGSGRMVVtavgvnsqtgiiftllgaggeeeekkdkkgkqqdg 311
Cdd:cd02073   127 PDglcyVETANLDGETNLkIRQALPETALLLSEEDLARFSGEIEC----------------------------------- 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  312 amDSSQTRAKKQDGAvaMEMQPLK----SAE-----GGEMEEREKKKANVpkkeksVLQGKLTKLAVQIGKAGLVMSAIT 382
Cdd:cd02073   172 --EQPNNDLYTFNGT--LELNGGRelplSPDnlllrGCTLRNTEWVYGVV------VYTGHETKLMLNSGGTPLKRSSIE 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  383 ------VIILVLYFVIETFV--VDGRVWLAECTP------------VYVQYFVKF--FIIgvtVLVVAVPegLPLAVTIS 440
Cdd:cd02073   242 kkmnrfIIAIFCILIVMCLIsaIGKGIWLSKHGRdlwyllpkeersPALEFFFDFltFII---LYNNLIP--ISLYVTIE 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  441 LAYSV--------KKMMKDNN----LVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAPSaltpki 508
Cdd:cd02073   317 VVKFLqsffinwdLDMYDEETdtpaEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGVDYGFFLALA------ 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  509 ldlLVHAISINSAYTTKILP-----PEkEGALPRQvgnkteCALLGFVLdLKRDFQPV-REQIPEDQLYK---VYTFNSV 579
Cdd:cd02073   391 ---LCHTVVPEKDDHPGQLVyqassPD-EAALVEA------ARDLGFVF-LSRTPDTVtINALGEEEEYEilhILEFNSD 459
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  580 RKSMSTVIRMPDGGFRLFSKGASEILLKKCTNilnSNGELRgfrprdrdDMVKKIIEPMACDGLRTICIAYRDFSAIQEP 659
Cdd:cd02073   460 RKRMSVIVRDPDGRILLYCKGADSVIFERLSP---SSLELV--------EKTQEHLEDFASEGLRTLCLAYREISEEEYE 528
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  660 DWDNE-------------------NEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCG 720
Cdd:cd02073   529 EWNEKydeastalqnreelldevaEEIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGYSCR 608
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  721 IIQPG-EDF-LCLEGKEFNrrirnekgEIEQERLDKVWPKLRVLA------RSSPTDKHTLVKGIIDSTTGeqrqVVAVT 792
Cdd:cd02073   609 LLSEDmENLaLVIDGKTLT--------YALDPELERLFLELALKCkaviccRVSPLQKALVVKLVKKSKKA----VTLAI 676
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  793 GDGTNDGPALKKADVGfaMGIAGtdvaKE------ASDIILTddNFTSIVKAVM-WGRNVYDSISKFLQFQLTVNVVAVI 865
Cdd:cd02073   677 GDGANDVSMIQEAHVG--VGISG----QEgmqaarASDYAIA--QFRFLRRLLLvHGRWSYQRLAKLILYFFYKNIAFYL 748
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  866 V-----AFTGAciTQDSPLKAVQMLWVNLImdtFASLalatePP----------TESLLLRKP--YgrdKPLISRTM--M 926
Cdd:cd02073   749 TqfwyqFFNGF--SGQTLYDSWYLTLYNVL---FTSL-----PPlvigifdqdvSAETLLRYPelY---KPGQLNELfnW 815
                         890
                  ....*....|....*...
gi 569010236  927 KNILG---HAVYQLTIIF 941
Cdd:cd02073   816 KVFLYwilDGIYQSLIIF 833
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
200-867 1.73e-39

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 155.51  E-value: 1.73e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   200 NGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDlKIDESSLTGESDHVRKSADkDPmLLSGTHVMEGSGRMVVTAV 279
Cdd:TIGR01511   99 DGSIEEVPVALLQPGDIVKVLPGEKIPVDGTVIEGES-EVDESLVTGESLPVPKKVG-DP-VIAGTVNGTGSLVVRATAT 175
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   280 GVNSqtgiifTLlgaggeeeekkdkkgkqqdgamdssqtrakkqdgAVAMEMqplksaeggeMEEREKKKAnvpkkeksv 359
Cdd:TIGR01511  176 GEDT------TL----------------------------------AQIVRL----------VRQAQQSKA--------- 196
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   360 lqgKLTKLAVQIGKAgLVMSAITVIILvlyfvieTFVVdgrvWLAEctpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTI 439
Cdd:TIGR01511  197 ---PIQRLADKVAGY-FVPVVIAIALI-------TFVI----WLFA------------LEFAVTVLIIACPCALGLATPT 249
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   440 SLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQ-SYLGDTHYKEIPAPSAltpkilDLLVH---- 514
Cdd:TIGR01511  250 VIAVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTVTDvHVFGDRDRTELLALAA------ALEAGsehp 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   515 -AISINSAYTTKILPPEKEGALPRQVGNKTECALLGFVLDLKRdfqpvREQIPEDQLykvyTFNSVRKSMSTVIrmpdgg 593
Cdd:TIGR01511  324 lAKAIVSYAKEKGITLVTVSDFKAIPGIGVEGTVEGTKIQLGN-----EKLLGENAI----KIDGKAGQGSTVV------ 388
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   594 frlfskgaseillkkctnILNSNGELRGfrprdrddmvkkiiepmacdglrticiayrdfsaiqepdwdnenevvgdltc 673
Cdd:TIGR01511  389 ------------------LVAVNGELAG---------------------------------------------------- 398
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   674 iaVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgedflclegkefnrrirnekgeieqerld 753
Cdd:TIGR01511  399 --VFALEDQLRPEAKEVIQALKRRGIEPVMLTGDNRKTAKAVAKELGI-------------------------------- 444
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   754 kvwpklRVLARSSPTDKHTLVKGIIdsttgEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFT 833
Cdd:TIGR01511  445 ------DVRAEVLPDDKAALIKKLQ-----EKGPVVAMVGDGINDAPALAQADVGIAIG-AGTDVAIEAADVVLLRNDLN 512
                          650       660       670
                   ....*....|....*....|....*....|....
gi 569010236   834 SIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 867
Cdd:TIGR01511  513 DVATAIDLSRKTLRRIKQNLLWAFGYNVIAIPIA 546
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
196-926 1.78e-36

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 149.79  E-value: 1.78e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  196 TVIR------NGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLKIDESSLTGES---------DHVR-KSADKDP 259
Cdd:PRK15122  151 TVLRrghagaEPVRREIPMRELVPGDIVHLSAGDMIPADVRLIESRDLFISQAVLTGEAlpvekydtlGAVAgKSADALA 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  260 -----------MLLSGTHVMEGSGRMVVTAVGvnsqtgiiftllgaggeeeekkdkkgkqqdgamdssqtrAKKQDGAVA 328
Cdd:PRK15122  231 ddegslldlpnICFMGTNVVSGTATAVVVATG---------------------------------------SRTYFGSLA 271
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  329 memqplksaeggemeerekkkanvpkkeKSVLqGKLTKLAVQIGkaglVMSaitVIILVLYFVIetfvvdgrvwlaectp 408
Cdd:PRK15122  272 ----------------------------KSIV-GTRAQTAFDRG----VNS---VSWLLIRFML---------------- 299
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  409 vyVQYFVKFFIIGVT----------VLVVAV---PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKT 475
Cdd:PRK15122  300 --VMVPVVLLINGFTkgdwleallfALAVAVgltPEMLPMIVSSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKT 377
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  476 GTLTTNRMTVVQSYlgDTHYKEipapsalTPKILDLlvhaISINSAYttkilppekegalprQVG--NKTECALLGFVlD 553
Cdd:PRK15122  378 GTLTQDRIILEHHL--DVSGRK-------DERVLQL----AWLNSFH---------------QSGmkNLMDQAVVAFA-E 428
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  554 LKRDFQPVREQIPEDQLykvyTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNsNGELRGFRPRDRDDMvKK 633
Cdd:PRK15122  429 GNPEIVKPAGYRKVDEL----PFDFVRRRLSVVVEDAQGQHLLICKGAVEEMLAVATHVRD-GDTVRPLDEARRERL-LA 502
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  634 IIEPMACDGLRTICIAYRDFSAIQEPDW---DNENEVV--GDLTCIavvgieDPVRPEVPEAIRKCQRAGITVRMVTGDN 708
Cdd:PRK15122  503 LAEAYNADGFRVLLVATREIPGGESRAQystADERDLVirGFLTFL------DPPKESAAPAIAALRENGVAVKVLTGDN 576
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  709 -INTARaIAAKCGIiQPGEDflcLEGKEFNRrirnekgeIEQERLDKVWPKLRVLARSSPTDKHTLVKGIidSTTGeqrQ 787
Cdd:PRK15122  577 pIVTAK-ICREVGL-EPGEP---LLGTEIEA--------MDDAALAREVEERTVFAKLTPLQKSRVLKAL--QANG---H 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  788 VVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLqfQLTV-----NVV 862
Cdd:PRK15122  639 TVGFLGDGINDAPALRDADVGISVD-SGADIAKESADIILLEKSLMVLEEGVIKGRETFGNIIKYL--NMTAssnfgNVF 715
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569010236  863 AVIVAftGACITQdSPLKAVQMLWVNLIMDtFASLALatepPTESL---LLRKPYGRDKPLISRTMM 926
Cdd:PRK15122  716 SVLVA--SAFIPF-LPMLAIHLLLQNLMYD-ISQLSL----PWDKMdkeFLRKPRKWDAKNIGRFML 774
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
69-947 1.78e-36

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 150.21  E-value: 1.78e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236    69 EGLAdnTNDLEKRRQIYGQNFIPPKQPkTFLQLVW-EALQdvTLIILEVAAIVSLGLSFYappgeeseacgnvsggaede 147
Cdd:TIGR01657  138 NGLT--TGDIAQRKAKYGKNEIEIPVP-SFLELLKeEVLH--PFYVFQVFSVILWLLDEY-------------------- 192
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   148 geaeagWIEGAAILL-SVICVVLVTafndWSKEKQFRGLQSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKY--GDL 224
Cdd:TIGR01657  193 ------YYYSLCIVFmSSTSISLSV----YQIRKQMQRLRDMVHKPQSVIVIRNGKWVTIASDELVPGDIVSIPRpeEKT 262
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   225 LPADGVLIQGnDLKIDESSLTGESDHVRKSADKDpmllsgthvmEGSGRMVVTAVGVNSqtgiIFTLLGAGGEEeekkdk 304
Cdd:TIGR01657  263 MPCDSVLLSG-SCIVNESMLTGESVPVLKFPIPD----------NGDDDEDLFLYETSK----KHVLFGGTKIL------ 321
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   305 kgkqqdgamdssQTRAKKQDGAVamemqplksaeggemeerekkKANVPKKEKSVLQGKL-----------TKLAVQIGK 373
Cdd:TIGR01657  322 ------------QIRPYPGDTGC---------------------LAIVVRTGFSTSKGQLvrsilypkprvFKFYKDSFK 368
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   374 AGLVMSAITVIILVlyFVIETFVVDGRvwlaectPVYvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNN 453
Cdd:TIGR01657  369 FILFLAVLALIGFI--YTIIELIKDGR-------PLG-----KIILRSLDIITIVVPPALPAELSIGINNSLARLKKKGI 434
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   454 LVRHLDACETMGNATAICSDKTGTLTTNRMTV--VQSYLGD-THYKEIPAPSALTPKILdllVHAISINSAyTTKIlppe 530
Cdd:TIGR01657  435 FCTSPFRINFAGKIDVCCFDKTGTLTEDGLDLrgVQGLSGNqEFLKIVTEDSSLKPSIT---HKALATCHS-LTKL---- 506
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   531 kEGALprqVGNKTECALLGFV-LDLKRD---------FQPVREQIP--EDQLYKVYTFNSVRKSMSTVIRMPDGGFR-LF 597
Cdd:TIGR01657  507 -EGKL---VGDPLDKKMFEATgWTLEEDdesaeptsiLAVVRTDDPpqELSIIRRFQFSSALQRMSVIVSTNDERSPdAF 582
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   598 SKGASEILLKKCtnilnSNGELrgfrPRDRDDMVKKIIEpmacDGLRTICIAYRD-----FSAIQEPDWDnenEVVGDLT 672
Cdd:TIGR01657  583 VKGAPETIQSLC-----SPETV----PSDYQEVLKSYTR----EGYRVLALAYKElpkltLQKAQDLSRD---AVESNLT 646
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   673 CIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQP---------------------------- 724
Cdd:TIGR01657  647 FLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECGIVNPsntlilaeaeppesgkpnqikfevidsi 726
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   725 ------------------GEDF-----LCLEGKEFNRRIRNEKgeieqERLDKVWPKLRVLARSSPTDKHTLVKgiidsT 781
Cdd:TIGR01657  727 pfastqveipyplgqdsvEDLLasryhLAMSGKAFAVLQAHSP-----ELLLRLLSHTTVFARMAPDQKETLVE-----L 796
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   782 TGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAkeASdiiltddnFTSIVKAVmwgRNVYDSIskfLQFQLT-VN 860
Cdd:TIGR01657  797 LQKLDYTVGMCGDGANDCGALKQADVGISLSEAEASVA--AP--------FTSKLASI---SCVPNVI---REGRCAlVT 860
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   861 VVAVIVAFTGACITQ----------DSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRdkpLISRTMMKNIL 930
Cdd:TIGR01657  861 SFQMFKYMALYSLIQfysvsilyliGSNLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSKERPPSN---LFSVYILTSVL 937
                          970
                   ....*....|....*..
gi 569010236   931 GhavyQLTIIFTLLFVG 947
Cdd:TIGR01657  938 I----QFVLHILSQVYL 950
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
197-867 2.79e-33

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 137.82  E-value: 2.79e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  197 VIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLkIDESSLTGESDHVRKSADKDpmLLSGTHVMEGSGRMVV 276
Cdd:cd07552   135 LVTDGSIEDVPVSELKVGDVVLVRAGEKIPADGTILEGESS-VNESMVTGESKPVEKKPGDE--VIGGSVNGNGTLEVKV 211
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  277 TAVGVNSQTGIIFTLLGaggeeeekkdkkgkqqdgamdssqtrakkqdgavamEMQPLKSaeggEMEEREKKKAnvpkke 356
Cdd:cd07552   212 TKTGEDSYLSQVMELVA------------------------------------QAQASKS----RAENLADKVA------ 245
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  357 ksvlqGKLTKLAVQIGkaglvmsAITVIIlvlyfvietfvvdgrvWLaectpvYVQYFVKFFIIGVTVLVVAVPEGL--- 433
Cdd:cd07552   246 -----GWLFYIALGVG-------IIAFII----------------WL------ILGDLAFALERAVTVLVIACPHALgla 291
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  434 -PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEipapsaltpKILDLL 512
Cdd:cd07552   292 iPLVVARSTSIAAKNGL----LIRNREALERARDIDVVLFDKTGTLTEGKFGVTDVITFDEYDED---------EILSLA 358
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  513 V-------H--AISINSAYTTKILPPEKegalPRQVGNKTECALLGFVldlkrdfqpvreqipEDQLYKVYTFNSVRKSm 583
Cdd:cd07552   359 AaleagseHplAQAIVSAAKEKGIRPVE----VENFENIPGVGVEGTV---------------NGKRYQVVSPKYLKEL- 418
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  584 stvirmpdgGFRLfskgaSEILLKkctnilnsngelrgfRPRDRDDMVKKIIEpmacdglrticiayrdfsaiqepdwdn 663
Cdd:cd07552   419 ---------GLKY-----DEELVK---------------RLAQQGNTVSFLIQ--------------------------- 442
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  664 ENEVVGdltciaVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIqpgedflclegkefnrrirne 743
Cdd:cd07552   443 DGEVIG------AIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGID--------------------- 495
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  744 kgeieqerldkvwpklRVLARSSPTDKHTLVKGIIDsttgeQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEAS 823
Cdd:cd07552   496 ----------------EYFAEVLPEDKAKKVKELQA-----EGKKVAMVGDGVNDAPALAQADVGIAIG-AGTDVAIESA 553
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 569010236  824 DIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 867
Cdd:cd07552   554 DVVLVKSDPRDIVDFLELAKATYRKMKQNLWWGAGYNVIAIPLA 597
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
167-868 5.87e-33

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 138.67  E-value: 5.87e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   167 VVLVT----AFNDWSkekqfRGLQSRIEQEQKFTVIRN-GQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLK--- 238
Cdd:TIGR01652   60 VLIVTaikeAIEDIR-----RRRRDKEVNNRLTEVLEGhGQFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDgvc 134
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   239 -IDESSLTGESD-HVRKSADKDPMLLSGTHVMEGSGRmvVTAVGVNSQtgiIFTLLGAGGEEEEKKDKKGKQQDGAMDSS 316
Cdd:TIGR01652  135 yVETANLDGETNlKLRQALEETQKMLDEDDIKNFSGE--IECEQPNAS---LYSFQGNMTINGDRQYPLSPDNILLRGCT 209
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   317 QTRAKKQDGAVAMEmqplksaeGGEMeeREKKKANVPKKEKSVLQGKLTKLAVQIGKAGLVMSaitvIILVLYFVIETFV 396
Cdd:TIGR01652  210 LRNTDWVIGVVVYT--------GHDT--KLMRNATQAPSKRSRLEKELNFLIIILFCLLFVLC----LISSVGAGIWNDA 275
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   397 VDGRVW---LAECTPVYVQYFVKFFIIGVTVLVVAVPegLPLAVTISLAYSVKKMMKDNNL------------VRHLDAC 461
Cdd:TIGR01652  276 HGKDLWyirLDVSERNAAANGFFSFLTFLILFSSLIP--ISLYVSLELVKSVQAYFINSDLqmyhektdtpasVRTSNLN 353
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   462 ETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIP--------------------------APSALTPKILDLL--- 512
Cdd:TIGR01652  354 EELGQVEYIFSDKTGTLTQNIMEFKKCSIAGVSYGDGFteikdgirerlgsyvenensmlveskGFTFVDPRLVDLLktn 433
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   513 -VHAISINSAYTT-----KILP---PEKEGALPRQVGNKTECAL------LGFVLdLKRDFQPVREQIP---EDQLYK-- 572
Cdd:TIGR01652  434 kPNAKRINEFFLAlalchTVVPefnDDGPEEITYQAASPDEAALvkaardVGFVF-FERTPKSISLLIEmhgETKEYEil 512
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   573 -VYTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKkctnILNSNGelrgfrpRDRDDMVKKIIEPMACDGLRTICIAYR 651
Cdd:TIGR01652  513 nVLEFNSDRKRMSVIVRNPDGRIKLLCKGADTVIFK----RLSSGG-------NQVNEETKEHLENYASEGLRTLCIAYR 581
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   652 DFSAIQEPDW-----------DNENEVVG--------DLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTA 712
Cdd:TIGR01652  582 ELSEEEYEEWneeyneastalTDREEKLDvvaesiekDLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLTGDKVETA 661
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   713 RAIAAKCGIIQPGEDFL---------CLEGKEFNRRIRNEKGEIEQERLDK---------------VWPKLR-------- 760
Cdd:TIGR01652  662 INIGYSCRLLSRNMEQIvitsdsldaTRSVEAAIKFGLEGTSEEFNNLGDSgnvalvidgkslgyaLDEELEkeflqlal 741
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   761 ----VLA-RSSPTDKHTLVKGIIDSTtgeQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTD--VAKEASDIILTddNFT 833
Cdd:TIGR01652  742 kckaVICcRVSPSQKADVVRLVKKST---GKTTLAI-GDGANDVSMIQEADVG--VGISGKEgmQAVMASDFAIG--QFR 813
                          810       820       830
                   ....*....|....*....|....*....|....*.
gi 569010236   834 SIVKAVMW-GRNVYDSISKFLQFQLTVNVVAVIVAF 868
Cdd:TIGR01652  814 FLTKLLLVhGRWSYKRISKMILYFFYKNLIFAIIQF 849
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
77-946 1.42e-32

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 136.61  E-value: 1.42e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   77 DLEKRRQIYGQNFIPPKQPKTFLQLVWEALQdvTLIILEVAAIVSLGLSFYAppgeeseacgnvsggaedegeaeagWIE 156
Cdd:cd07542     2 EQSDRRLIYGPNEIDVPLKSILKLLFKEVLN--PFYVFQLFSVILWSSDDYY-------------------------YYA 54
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  157 GAAILLSVICVVLVTafndWSKEKQFRGLQSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKY-GDLLPADGVLIQGN 235
Cdd:cd07542    55 ACIVIISVISIFLSL----YETRKQSKRLREMVHFTCPVRVIRDGEWQTISSSELVPGDILVIPDnGTLLPCDAILLSGS 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  236 DLkIDESSLTGESDHVRKSA--DKDPMLLSGTHVMEGSGRMVVTavgvnSQTGIIftllgaggeeeekkdkkgkqqdgam 313
Cdd:cd07542   131 CI-VNESMLTGESVPVTKTPlpDESNDSLWSIYSIEDHSKHTLF-----CGTKVI------------------------- 179
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  314 dssQTRAKKQDGAVAMEMQPLKSAEGGEMeerekkkanV-----PK-KEKSVLQGKLTKLAVQIGKAGLVMsAITVIILV 387
Cdd:cd07542   180 ---QTRAYEGKPVLAVVVRTGFNTTKGQL---------VrsilyPKpVDFKFYRDSMKFILFLAIIALIGF-IYTLIILI 246
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  388 LYFVietfvvdgrvwlaectpvyvqYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKmmkdnnLVRHLDAC---ETM 464
Cdd:cd07542   247 LNGE---------------------SLGEIIIRALDIITIVVPPALPAALTVGIIYAQSR------LKKKGIFCispQRI 299
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  465 GNATAI---CSDKTGTLTTNRMTV--VQSYLGDTHYKEIPAPSALTPKILDLLVHAISinSAYTTKILppekegalpRQV 539
Cdd:cd07542   300 NICGKInlvCFDKTGTLTEDGLDLwgVRPVSGNNFGDLEVFSLDLDLDSSLPNGPLLR--AMATCHSL---------TLI 368
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  540 GNKtecaLLGFVLDLKRdFQPVREQIpedQLYKVYTFNSVRKSMSTVIRMP-DGGFRLFSKGASEILLKKC-TNILnsng 617
Cdd:cd07542   369 DGE----LVGDPLDLKM-FEFTGWSL---EILRQFPFSSALQRMSVIVKTPgDDSMMAFTKGAPEMIASLCkPETV---- 436
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  618 elrgfrPRDRDDMVKKiiepMACDGLRTICIAYRdfsAIQEPDWDNEN----EVVGDLTCIAVVGIEDPVRPEVPEAIRK 693
Cdd:cd07542   437 ------PSNFQEVLNE----YTKQGFRVIALAYK---ALESKTWLLQKlsreEVESDLEFLGLIVMENRLKPETAPVINE 503
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  694 CQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDFLCLEGKEfnrrirnEKGEIEQERLDKVWPKLRVLARSSPTDKHTL 773
Cdd:cd07542   504 LNRANIRTVMVTGDNLLTAISVARECGMISPSKKVILIEAVK-------PEDDDSASLTWTLLLKGTVFARMSPDQKSEL 576
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  774 VKGI--IDSTtgeqrqvVAVTGDGTNDGPALKKADVGFAMGIAGTDVAkeASdiiltddnFTSIVKAVmwgRNVYDSISK 851
Cdd:cd07542   577 VEELqkLDYT-------VGMCGDGANDCGALKAADVGISLSEAEASVA--AP--------FTSKVPDI---SCVPTVIKE 636
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  852 --------FLQFQLTvnVVAVIVAFTGACI--TQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRdkpLI 921
Cdd:cd07542   637 graalvtsFSCFKYM--ALYSLIQFISVLIlySINSNLGDFQFLFIDLVIITPIAVFMSRTGAYPKLSSKRPPAS---LV 711
                         890       900
                  ....*....|....*....|....*
gi 569010236  922 SRTMMKNILGHAVYQLTIIFTLLFV 946
Cdd:cd07542   712 SPPVLVSLLGQIVLILLFQVIGFLI 736
E1-E2_ATPase pfam00122
E1-E2 ATPase;
196-450 3.27e-32

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 123.84  E-value: 3.27e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   196 TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLkIDESSLTGESDHVRKsaDKDPMLLSGTHVMEGSGRMV 275
Cdd:pfam00122    8 TVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEK--KKGDMVYSGTVVVSGSAKAV 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   276 VTAVGVNSQTGIIFTLlgaggeeeekkdkkgkqqdgamdssqtrakkqdgavamemqplksaeggeMEEREKKKANvpkk 355
Cdd:pfam00122   85 VTATGEDTELGRIARL--------------------------------------------------VEEAKSKKTP---- 110
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   356 eksvLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVvdgrvwlaectpvyvqyfvkfFIIGVTVLVVAVPEGLPL 435
Cdd:pfam00122  111 ----LQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPLRA---------------------LLRALAVLVAACPCALPL 165
                          250
                   ....*....|....*
gi 569010236   436 AVTISLAYSVKKMMK 450
Cdd:pfam00122  166 ATPLALAVGARRLAK 180
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
175-870 5.53e-30

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 127.01  E-value: 5.53e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  175 DWSKEKQFRGL-QSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLkIDESSLTGESDHVRK 253
Cdd:cd07550    81 DYTARKSEKALlDLLSPQERTVWVERDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEK 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  254 SADKdpMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdkkgkqqdgamdssqtrakkqdgavamemqp 333
Cdd:cd07550   160 REGD--LVFASTVVEEGQLVIRAERVGRETRAARIAEL------------------------------------------ 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  334 lksaeggeMEEREKKKANvpkkeksvLQGKLTKLAVQigkaglvmsaitviiLVLYfvieTFVVDGRVWLaectpvyvqy 413
Cdd:cd07550   196 --------IEQSPSLKAR--------IQNYAERLADR---------------LVPP----TLGLAGLVYA---------- 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  414 FVKFFIIGVTVLVV----AVPEGLPLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSy 489
Cdd:cd07550   231 LTGDISRAAAVLLVdfscGIRLSTPVAVLSALNHAARHGI----LVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTAI- 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  490 lgdthykeIPAPSALTPKilDLLVHAISINSAYTtkiLPpekegaLPRQVGNKTEcallgfvldlkrdfqpvREQIPEDQ 569
Cdd:cd07550   306 --------ITFDGRLSEE--DLLYLAASAEEHFP---HP------VARAIVREAE-----------------ERGIEHPE 349
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  570 LYKVYTFnsVRKSMSTVIrmpdggfrlfskGASEILLkkctnilnsnGELRGFRPRDRDDM--VKKIIEPMACDGLRTIC 647
Cdd:cd07550   350 HEEVEYI--VGHGIASTV------------DGKRIRV----------GSRHFMEEEEIILIpeVDELIEDLHAEGKSLLY 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  648 IAYrdfsaiqepdwdnENEVVGdltciaVVGIEDPVRPEVPEAIRKCQRAG-ITVRMVTGDNINTARAIAAKCGIiqpge 726
Cdd:cd07550   406 VAI-------------DGRLIG------VIGLSDPLRPEAAEVIARLRALGgKRIIMLTGDHEQRARALAEQLGI----- 461
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  727 dflclegkefnrrirnekgeieqerlDkvwpklRVLARSSPTDKHTLVKGIidsttgeQRQ--VVAVTGDGTNDGPALKK 804
Cdd:cd07550   462 --------------------------D------RYHAEALPEDKAEIVEKL-------QAEgrTVAFVGDGINDSPALSY 502
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569010236  805 ADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 870
Cdd:cd07550   503 ADVGISMR-GGTDIARETADVVLLEDDLRGLAEAIELARETMALIKRNIALVVGPNTAVLAGGVFG 567
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
199-870 1.36e-29

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 126.21  E-value: 1.36e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  199 RNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDlKIDESSLTGESDHVRKSADKDpmLLSGTHVMEGSGRMVVTA 278
Cdd:cd07551   119 RDGEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSS-SIDEASITGESIPVEKTPGDE--VFAGTINGSGALTVRVTK 195
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  279 vgvnsqtgiiftllgaggeeeekkdkkgkqqdgamDSSQTrakkqdgAVAMEMQPLKSAEGgemeerekkkanvpkkEKS 358
Cdd:cd07551   196 -----------------------------------LSSDT-------VFAKIVQLVEEAQS----------------EKS 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  359 VLQGKLTKLavQIGKAGLVMSAITVIILVLYFVIetfvvdGRVWLAEctpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVT 438
Cdd:cd07551   218 PTQSFIERF--ERIYVKGVLLAVLLLLLLPPFLL------GWTWADS------------FYRAMVFLVVASPCALVASTP 277
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  439 ISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYlgdthykeiPAPSALTPKILDLLVhAISI 518
Cdd:cd07551   278 PATLSAIANAARQGVLFKGGVHLENLGSVKAIAFDKTGTLTEGKPRVTDVI---------PAEGVDEEELLQVAA-AAES 347
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  519 NS------AYTTKILPPEKEGALPRQVGNKTECALLGFVldlkrdfqpvreqipEDQLYKVytfnsvrksmstvirmpdG 592
Cdd:cd07551   348 QSehplaqAIVRYAEERGIPRLPAIEVEAVTGKGVTATV---------------DGQTYRI------------------G 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  593 GFRLFSKGASEILLKKCTNILNSNGelrgfrprdrddmvkkiiepmacdglRTICIAYRDfsaiqepdwdnenEVVgdlt 672
Cdd:cd07551   395 KPGFFGEVGIPSEAAALAAELESEG--------------------------KTVVYVARD-------------DQV---- 431
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  673 cIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgedflclegkefnrrirnekgeieqerl 752
Cdd:cd07551   432 -VGLIALMDTPRPEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELGI------------------------------- 479
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  753 DKVWPKLRvlarssPTDKHTLVKgiidsttgEQRQ---VVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTD 829
Cdd:cd07551   480 DEVVANLL------PEDKVAIIR--------ELQQeygTVAMVGDGINDAPALANADVGIAMG-AGTDVALETADVVLMK 544
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|.
gi 569010236  830 DNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 870
Cdd:cd07551   545 DDLSKLPYAIRLSRKMRRIIKQNLIFALAVIALLIVANLFG 585
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
154-897 1.67e-28

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 122.53  E-value: 1.67e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  154 WIEGAAIllsVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKF-TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLI 232
Cdd:cd07545    59 WPEAAMV---VFLFAISEALEAYSMDRARRSIRSLMDIAPKTaLVRRDGQEREVPVAEVAVGDRMIVRPGERIAMDGIIV 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  233 QGNDLkIDESSLTGESDHVRKSADKDpmLLSGTHVMEGSGRMVVTAvgvnsqtgiiftllgaggeeeekkdkkgkqqdga 312
Cdd:cd07545   136 RGESS-VNQAAITGESLPVEKGVGDE--VFAGTLNGEGALEVRVTK---------------------------------- 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  313 mdssqtRAkkQDGAVAMEMQPLKSAEGgemeerekkkanvpkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFvi 392
Cdd:cd07545   179 ------PA--EDSTIARIIHLVEEAQA----------------ERAPTQAFVDRFARYYTPVVMAIAALVAIVPPLFF-- 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  393 etfvvdGRVWLaecTPVYVqyfvkffiiGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICS 472
Cdd:cd07545   233 ------GGAWF---TWIYR---------GLALLVVACPCALVISTPVSIVSAIGNAARKGVLIKGGVYLEELGRLKTVAF 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  473 DKTGTLTTNRMTVVQSY-LGDTHYKEIPA-PSALTPKILDLLVHAIsINSAyttkilppEKEGALPRQVGNKTecALLGf 550
Cdd:cd07545   295 DKTGTLTKGKPVVTDVVvLGGQTEKELLAiAAALEYRSEHPLASAI-VKKA--------EQRGLTLSAVEEFT--ALTG- 362
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  551 vldlkrdfQPVREQIPEDQLYKvytfnsvrksmstvirmpdGGFRLFS-KGASEIL-LKKCTNILNSNGElrgfrprdrd 628
Cdd:cd07545   363 --------RGVRGVVNGTTYYI-------------------GSPRLFEeLNLSESPaLEAKLDALQNQGK---------- 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  629 dmvkkiiEPMacdglrticiayrdfsaiqepdwdneneVVGDLTCI-AVVGIEDPVRPEVPEAIRKCQRAGI--TVrMVT 705
Cdd:cd07545   406 -------TVM----------------------------ILGDGERIlGVIAVADQVRPSSRNAIAALHQLGIkqTV-MLT 449
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  706 GDNINTARAIAAKCGIiqpgedflclegkefnrrirnekGEIEQERLdkvwpklrvlarssPTDKHTLVKGIIdsttgEQ 785
Cdd:cd07545   450 GDNPQTAQAIAAQVGV-----------------------SDIRAELL--------------PQDKLDAIEALQ-----AE 487
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  786 RQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVI 865
Cdd:cd07545   488 GGRVAMVGDGVNDAPALAAADVGIAMGAAGTDTALETADIALMGDDLRKLPFAVRLSRKTLAIIKQNIAFALGIKLIALL 567
                         730       740       750
                  ....*....|....*....|....*....|..
gi 569010236  866 VAFTGacitqdsplkaVQMLWVNLIMDTFASL 897
Cdd:cd07545   568 LVIPG-----------WLTLWMAVFADMGASL 588
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
193-870 3.55e-26

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 115.11  E-value: 3.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  193 QKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLkIDESSLTGESDHVRKSADKDpmLLSGTHVMEGSG 272
Cdd:cd07544   110 RIAHRLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEVVSGTAT-LDESSLTGESKPVSKRPGDR--VMSGAVNGDSAL 186
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  273 RMVVTAVGVNSQTGIIFTLlgaggeeeekkdkkgkqqdgamdssqtrakkqdgavamemqplksaeggeMEEREKKKAnv 352
Cdd:cd07544   187 TMVATKLAADSQYAGIVRL--------------------------------------------------VKEAQANPA-- 214
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  353 pkkeksvlqgKLTKLAVQIGkaglvmsaitviilvLYFVIETFVVDGRVWLAECTPVYVqyfvkffiigVTVLVVAVPEG 432
Cdd:cd07544   215 ----------PFVRLADRYA---------------VPFTLLALAIAGVAWAVSGDPVRF----------AAVLVVATPCP 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  433 LPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSylgdthykeIPAPSALTPKILDLL 512
Cdd:cd07544   260 LILAAPVAIVSGMSRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLTYGQPKVVDV---------VPAPGVDADEVLRLA 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  513 -------VHAI--SINSAYTTKILPPekegALPRQVGNKTECALLGFVldlkrdfqpvreqipEDQLYKVYTFNSVRKsm 583
Cdd:cd07544   331 asveqysSHVLarAIVAAARERELQL----SAVTELTEVPGAGVTGTV---------------DGHEVKVGKLKFVLA-- 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  584 stvirmpdggfrlfskgaseillkkctnilnsngelrgfRPRDRDDMVKKIIEPMACdglrticiayrdfsaiqepdwdn 663
Cdd:cd07544   390 ---------------------------------------RGAWAPDIRNRPLGGTAV----------------------- 407
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  664 eneVVG-DLTCIAVVGIEDPVRPEVPEAIRKCQRAGIT-VRMVTGDNINTARAIAAKCGIIQpgedflclegkefnrrir 741
Cdd:cd07544   408 ---YVSvDGKYAGAITLRDEVRPEAKETLAHLRKAGVErLVMLTGDRRSVAEYIASEVGIDE------------------ 466
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  742 nekgeieqerldkvwpklrVLARSSPTDKHTLVKGIidsttgEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKE 821
Cdd:cd07544   467 -------------------VRAELLPEDKLAAVKEA------PKAGPTIMVGDGVNDAPALAAADVGIAMGARGSTAASE 521
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569010236  822 ASDIILTDDNFTSIVKAVMWGRnvyDSISKFLQFQL---TVNVVAVIVAFTG 870
Cdd:cd07544   522 AADVVILVDDLDRVVDAVAIAR---RTRRIALQSVLigmALSIIGMLIAAFG 570
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
196-901 4.26e-25

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 111.73  E-value: 4.26e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  196 TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDlKIDESSLTGESDHVRKSA-DKdpmLLSGTHVMEGSGRM 274
Cdd:cd07546   102 LREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKAAgDK---VFAGSINVDGVLRI 177
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  275 VVTAVGVNSQTGIIFTLLgaggeeeekkdkkgkqqdgamdssqtrakkqdgavamemqplksaeggemEEREKKKAnvPk 354
Cdd:cd07546   178 RVTSAPGDNAIDRILHLI--------------------------------------------------EEAEERRA--P- 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  355 keksvLQGKLTKLAVQIGKAGLVMSAITVIILVLYFvietfvvdGRVWLaecTPVYVqyfvkffiiGVTVLVVAVPEGL- 433
Cdd:cd07546   205 -----IERFIDRFSRWYTPAIMAVALLVIVVPPLLF--------GADWQ---TWIYR---------GLALLLIGCPCALv 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  434 ---PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqsylgdthykEIPAPSALTPKILD 510
Cdd:cd07546   260 istPAAITSGLAAAARRGA----LIKGGAALEQLGRVTTVAFDKTGTLTRGKPVVT----------DVVPLTGISEAELL 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  511 LLVHAISINSAY---TTKILPPEKEGALPRQVGNKTecALLGFVLDLKRDFQPVREQIPedqlykvytfnsvrksmstvi 587
Cdd:cd07546   326 ALAAAVEMGSSHplaQAIVARAQAAGLTIPPAEEAR--ALVGRGIEGQVDGERVLIGAP--------------------- 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  588 RMPDGGFRLFSKGASEILlkkctnilnsngELRGfrprdrddmvkkiiepmacdglRTICIAYRdfsaiqepdwdneNEV 667
Cdd:cd07546   383 KFAADRGTLEVQGRIAAL------------EQAG----------------------KTVVVVLA-------------NGR 415
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  668 VgdltcIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgeDFlclegkefnrrirneKGEI 747
Cdd:cd07546   416 V-----LGLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELGL-----DF---------------RAGL 470
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  748 EQErlDKVwpklrvlarssptdkhtlvkGIIDSTTgeQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIIL 827
Cdd:cd07546   471 LPE--DKV--------------------KAVRELA--QHGPVAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAAL 525
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569010236  828 TDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacITQdsplkavqmLWVNLIMDTFASlALAT 901
Cdd:cd07546   526 THNRLGGVAAMIELSRATLANIRQNITIALGLKAVFLVTTLLG--ITG---------LWLAVLADTGAT-VLVT 587
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
385-811 3.45e-24

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 109.78  E-value: 3.45e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  385 ILVLYFVIETFVVDGRVWLAECTPVYVQYfvKFFIIGVTVLVVAVPEGLP----LAVTISLAYSVKKMMKDNNLVR---- 456
Cdd:cd07543   231 IFILFLLVFAIAAAAYVWIEGTKDGRSRY--KLFLECTLILTSVVPPELPmelsLAVNTSLIALAKLYIFCTEPFRipfa 308
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  457 -HLDACetmgnataiCSDKTGTLTTNRMtVVQSYLGDTHYKE-IPAPSALTPKILDLLVHAISinsayttkiLPPEKEGA 534
Cdd:cd07543   309 gKVDIC---------CFDKTGTLTSDDL-VVEGVAGLNDGKEvIPVSSIEPVETILVLASCHS---------LVKLDDGK 369
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  535 LprqVGNKTECALLGFV---LDLKRDFQPVREQIPEDQLYKVYTFNSVRKSMSTVI---RMPDGGFRLFS--KGASEILL 606
Cdd:cd07543   370 L---VGDPLEKATLEAVdwtLTKDEKVFPRSKKTKGLKIIQRFHFSSALKRMSVVAsykDPGSTDLKYIVavKGAPETLK 446
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  607 KKCTNIlnsngelrgfrPRDRDDMVKKiiepMACDGLRTICIAYRDF---SAIQEPDWDNENeVVGDLTCIAVVGIEDPV 683
Cdd:cd07543   447 SMLSDV-----------PADYDEVYKE----YTRQGSRVLALGYKELghlTKQQARDYKRED-VESDLTFAGFIVFSCPL 510
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  684 RPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQpgedflclegkefNRRIRNEKGEIEQERLDKVWPKLRVLA 763
Cdd:cd07543   511 KPDSKETIKELNNSSHRVVMITGDNPLTACHVAKELGIVD-------------KPVLILILSEEGKSNEWKLIPHVKVFA 577
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 569010236  764 RSSPTDKHTLVkgiidSTTGEQRQVVAVTGDGTNDGPALKKADVGFAM 811
Cdd:cd07543   578 RVAPKQKEFII-----TTLKELGYVTLMCGDGTNDVGALKHAHVGVAL 620
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
207-819 5.70e-24

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 109.22  E-value: 5.70e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  207 PVAA--LVVGDIAQVKY-GDLLPADGVLIQGNdLKIDESSLTGESDHVRKSADKDPMllsgthvmegsgrmvVTAVGVNS 283
Cdd:cd02082    99 TIASnmIVPGDIVLIKRrEVTLPCDCVLLEGS-CIVTEAMLTGESVPIGKCQIPTDS---------------HDDVLFKY 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  284 QTGIIFTLLGAGGEEeekkdkkgkqqdgamdssQTRAKKQDGAVAMEMQPLKSAEGGEMEerekkkanvpkkeKSVLQGK 363
Cdd:cd02082   163 ESSKSHTLFQGTQVM------------------QIIPPEDDILKAIVVRTGFGTSKGQLI-------------RAILYPK 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  364 LTKLAVQigkaglvMSAITVIILVLYFVIETFVVDGRVWLAECTPVYvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAY 443
Cdd:cd02082   212 PFNKKFQ-------QQAVKFTLLLATLALIGFLYTLIRLLDIELPPL-----FIAFEFLDILTYSVPPGLPMLIAITNFV 279
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  444 SVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMtVVQSYLGDTHYKEIPAPSALTPKILDLLVHAISINSAyT 523
Cdd:cd02082   280 GLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKL-DLIGYQLKGQNQTFDPIQCQDPNNISIEHKLFAICHS-L 357
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  524 TKIlppekEGALprqVGNKTECALLGFV-LDLKRDFQpvREQIPED------QLYKVYTFNSVRKSMSTVIRMPDGGFR- 595
Cdd:cd02082   358 TKI-----NGKL---LGDPLDVKMAEAStWDLDYDHE--AKQHYSKsgtkrfYIIQVFQFHSALQRMSVVAKEVDMITKd 427
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  596 ----LFSKGASEILLKKCTNIlnsngelrgfrPRDRddmvKKIIEPMACDGLRTICIAYRDF--SAIQEPDWDNENEVVG 669
Cdd:cd02082   428 fkhyAFIKGAPEKIQSLFSHV-----------PSDE----KAQLSTLINEGYRVLALGYKELpqSEIDAFLDLSREAQEA 492
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  670 DLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDFLCLEGKEfnrrIRNEKGEIEQ 749
Cdd:cd02082   493 NVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQELEIINRKNPTIIIHLLI----PEIQKDNSTQ 568
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  750 ERLdkvWPKLRVLARSSPTDKHTLVKGIidsttGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVA 819
Cdd:cd02082   569 WIL---IIHTNVFARTAPEQKQTIIRLL-----KESDYIVCMCGDGANDCGALKEADVGISLAEADASFA 630
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
192-866 1.02e-21

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 101.91  E-value: 1.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  192 EQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLK----IDESSLTGESD-HVRKSADKDPMLLSGTH 266
Cdd:cd07536    82 KKQLYSKLTGRKVQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTSEPQgscyVETAQLDGETDlKLRVAVSCTQQLPALGD 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  267 VMEGSGRMV--VTAVGVNSQTGIiFTLLGAGGEEEEKKDKKGKQqdgaMDSSQTRAKKQDGAVamemqplkSAEGGEmEE 344
Cdd:cd07536   162 LMKISAYVEcqKPQMDIHSFEGN-FTLEDSDPPIHESLSIENTL----LRASTLRNTGWVIGV--------VVYTGK-ET 227
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  345 REKKKANVPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVlyFVIETFVVDGRVWLAECTPVYVQYFVKF-FIIGVT 423
Cdd:cd07536   228 KLVMNTSNAKNKVGLLDLELNRLTKALFLALVVLSLVMVTLQG--FWGPWYGEKNWYIKKMDTTSDNFGRNLLrFLLLFS 305
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  424 VLVvavpeglPLAVTISL----AYSVKKMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTTNRMTVVQSY 489
Cdd:cd07536   306 YII-------PISLRVNLdmvkAVYAWFIMWDENMyyigndtgtvARTSTIPEELGQVVYLLTDKTGTLTQNEMIFKRCH 378
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  490 LGDTHYkeipAPSALTPKILDLLvhaisinsayttkilppekegalprqvgnktecallgfvldlkrdfqpvreqipedq 569
Cdd:cd07536   379 IGGVSY----GGQVLSFCILQLL--------------------------------------------------------- 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  570 lykvyTFNSVRKSMSTVIRMPDGG-FRLFSKGASEILLKKCTnilnsngelRGFRPRDRDDMVkkiiEPMACDGLRTICI 648
Cdd:cd07536   398 -----EFTSDRKRMSVIVRDESTGeITLYMKGADVAISPIVS---------KDSYMEQYNDWL----EEECGEGLRTLCV 459
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  649 AYRDFSAIQEPDW------------DNENEVVG-------DLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNI 709
Cdd:cd07536   460 AKKALTENEYQEWesryteaslslhDRSLRVAEvveslerELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQ 539
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  710 NTARAIAAKCGIIQP-------------GED-----FLCLEGKEFNRR------IRNEKGEIEQERLDKVWPKLRVLA-- 763
Cdd:cd07536   540 ETAICIAKSCHLVSRtqdihllrqdtsrGERaaitqHAHLELNAFRRKhdvalvIDGDSLEVALKYYRHEFVELACQCpa 619
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  764 ----RSSPTDKHTLVKgIIDSTTGeqRQVVAVtGDGTNDGPALKKADVGfaMGIAGTD--VAKEASDIILTddNFTSIVK 837
Cdd:cd07536   620 viccRVSPTQKARIVT-LLKQHTG--RRTLAI-GDGGNDVSMIQAADCG--VGISGKEgkQASLAADYSIT--QFRHLGR 691
                         730       740       750
                  ....*....|....*....|....*....|
gi 569010236  838 AVM-WGRNVYDSISKFLQFQLTVNVVAVIV 866
Cdd:cd07536   692 LLLvHGRNSYNRSAALGQYVFYKGLIISTI 721
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
200-843 1.93e-20

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 97.33  E-value: 1.93e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  200 NGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNdLKIDESSLTGESDHV-RKSADKDPMLLSGTHVMegSGRMVVTa 278
Cdd:cd02078   103 DGKIEKVPATDLKKGDIVLVEAGDIIPADGEVIEGV-ASVDESAITGESAPViRESGGDRSSVTGGTKVL--SDRIKVR- 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  279 vgVNSQTGIIFTllgaggeeeekkdkkgkqqdgamdssqtrakkqDGAVAMemqplksAEGGEmeeREKkkanVPkkeks 358
Cdd:cd02078   179 --ITANPGETFL---------------------------------DRMIAL-------VEGAS---RQK----TP----- 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  359 vlqgklTKLAVQIGKAGLvmSAITVIILVLYFVIETFVVdgrvwlaecTPVYVqyfvkffIIGVTVLVVAVPE---GLPL 435
Cdd:cd02078   205 ------NEIALTILLVGL--TLIFLIVVATLPPFAEYSG---------APVSV-------TVLVALLVCLIPTtigGLLS 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  436 AVTISlaySVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTT-NRMTVvqsylgdthyKEIPAPSAlTPKILdllvh 514
Cdd:cd02078   261 AIGIA---GMDRLLRFNVIAKSGRAVEAAGDVDTLLLDKTGTITLgNRQAT----------EFIPVGGV-DEKEL----- 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  515 aisINSAYTTKILPPEKEG----ALPRQVGNKtecallgfvldlKRDFQPvreqipedQLYKVYTFnSVRKSMSTViRMP 590
Cdd:cd02078   322 ---ADAAQLASLADETPEGrsivILAKQLGGT------------ERDLDL--------SGAEFIPF-SAETRMSGV-DLP 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  591 DGgfRLFSKGASEILLKKctnILNSNGELrgfrprdrDDMVKKIIEPMACDGLRTICIAyrdfsaiqepdwdNENEVVGd 670
Cdd:cd02078   377 DG--TEIRKGAVDAIRKY---VRSLGGSI--------PEELEAIVEEISKQGGTPLVVA-------------EDDRVLG- 429
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  671 ltciaVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgEDFLclegkefnrrirnekgeieqe 750
Cdd:cd02078   430 -----VIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV----DDFL--------------------- 479
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  751 rldkvwpklrvlARSSPTDKHTLVKgiidsTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDD 830
Cdd:cd02078   480 ------------AEAKPEDKLELIR-----KEQAKGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAGNMVDLDS 541
                         650
                  ....*....|...
gi 569010236  831 NFTSIVKAVMWGR 843
Cdd:cd02078   542 DPTKLIEVVEIGK 554
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
519-612 3.88e-20

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 86.12  E-value: 3.88e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   519 NSAyttkILPPEKEGALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDQlykVYTFNSVRKSMSTVIRMP-DGGFRLF 597
Cdd:pfam13246    4 NSA----AFDENEEKGKWEIVGDPTESALLVFAEKMGIDVEELRKDYPRVA---EIPFNSDRKRMSTVHKLPdDGKYRLF 76
                           90
                   ....*....|....*
gi 569010236   598 SKGASEILLKKCTNI 612
Cdd:pfam13246   77 VKGAPEIILDRCTTI 91
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1100-1175 1.17e-18

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 80.53  E-value: 1.17e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569010236  1100 GQILWFRGLNRIQTQmevvstfkrsgsfqgavrrrssvlsqlhdIRVVKAFRSSLYEGLEKPESKSCIHNFMATPE 1175
Cdd:pfam12424    1 GQILWFRGLNRIQTQ-----------------------------IRVVKAFQSSLREGIQKPYLRNSIHSFMSHPE 47
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
435-855 2.85e-18

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 90.93  E-value: 2.85e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  435 LAVTISLAYSV--KKMMKDNNL----VRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPapsaLTPKI 508
Cdd:cd07541   288 LRVNLDMAKIVysWQIEHDKNIpgtvVRTSTIPEELGRIEYLLSDKTGTLTQNEMVFKKLHLGTVSYGGQN----LNYEI 363
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  509 LdllvhaisinsayttkilppekegalprqvgnktecallgfvldlkrdfqpvreqipedqlyKVYTFNSVRKSMSTVIR 588
Cdd:cd07541   364 L--------------------------------------------------------------QIFPFTSESKRMGIIVR 381
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  589 MP-DGGFRLFSKGASEILlkkcTNILNSNgelrgfrprdrdDMVKKIIEPMACDGLRTICIAYRDFSAIQEPDWDNE--- 664
Cdd:cd07541   382 EEkTGEITFYMKGADVVM----SKIVQYN------------DWLEEECGNMAREGLRTLVVAKKKLSEEEYQAFEKRyna 445
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  665 ------------NEVVG----DLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDF 728
Cdd:cd07541   446 aklsihdrdlkvAEVVEslerELELLCLTGVEDKLQEDVKPTLELLRNAGIKIWMLTGDKLETATCIAKSSKLVSRGQYI 525
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  729 -----LCLEGKEFN-----RRIRNEK------------GEIEQERLDKVWPKLRVLA-RSSPTDKHTLVKGIIDSTtgeQ 785
Cdd:cd07541   526 hvfrkVTTREEAHLelnnlRRKHDCAlvidgeslevclKYYEHEFIELACQLPAVVCcRCSPTQKAQIVRLIQKHT---G 602
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569010236  786 RQVVAVtGDGTNDGPALKKADVGfaMGIAGTDvAKEAS---DIILTDdnFTSIVKAVMW-GRNVYDSISKFLQF 855
Cdd:cd07541   603 KRTCAI-GDGGNDVSMIQAADVG--VGIEGKE-GKQASlaaDFSITQ--FSHIGRLLLWhGRNSYKRSAKLAQF 670
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
196-843 1.40e-17

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 88.06  E-value: 1.40e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  196 TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLkIDESSLTGESdhVRKSADKDPMLLSGTHVMEGSGRMV 275
Cdd:cd07548   112 NLKRNNELKDVKPEEVQIGDIIVVKPGEKIPLDGVVLKGESF-LDTSALTGES--VPVEVKEGSSVLAGFINLNGVLEIK 188
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  276 VTAvgvnsqtgiiftllgaggeeeekkdkkgkqqdgamdssqtraKKQDGAVAMEMQPLKSAEGgemeerekkkanvpkk 355
Cdd:cd07548   189 VTK------------------------------------------PFKDSAVAKILELVENASA---------------- 210
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  356 EKSVLQGKLTKLAvqigkagLVMSAITVIILVLYFVIETFVVDG---RVWLAEctpvyvqyfvkffiiGVTVLVVAVPEG 432
Cdd:cd07548   211 RKAPTEKFITKFA-------RYYTPIVVFLALLLAVIPPLFSPDgsfSDWIYR---------------ALVFLVISCPCA 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  433 LPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSylgdthykeIPAPSALTPKILDLL 512
Cdd:cd07548   269 LVISIPLGYFGGIGAASRKGILIKGSNYLEALSQVKTVVFDKTGTLTKGVFKVTEI---------VPAPGFSKEELLKLA 339
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  513 VH---------AISINSAYTTKILPPEkegalprqVGNKTECALLGfvldlkrdfqpVREQIPEDQLYKvytfnsvrksm 583
Cdd:cd07548   340 ALaesnsnhpiARSIQKAYGKMIDPSE--------IEDYEEIAGHG-----------IRAVVDGKEILV----------- 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  584 stvirmpdGGFRLFSKgaseillkkcTNILNSNGELRGfrprdrddmvkkiiepmacdglRTICIAYrdfsaiqepdwdn 663
Cdd:cd07548   390 --------GNEKLMEK----------FNIEHDEDEIEG----------------------TIVHVAL------------- 416
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  664 ENEVVGdltCIAvvgIEDPVRPEVPEAIRKCQRAGIT-VRMVTGDNINTARAIAAKCGIiqpgedflclegkefnrrirn 742
Cdd:cd07548   417 DGKYVG---YIV---ISDEIKEDAKEAIKGLKELGIKnLVMLTGDRKSVAEKVAKKLGI--------------------- 469
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  743 ekgeieqerlDKVWPKLrvlarsSPTDKHTLVKGIIDSTTGEqrqvVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEA 822
Cdd:cd07548   470 ----------DEVYAEL------LPEDKVEKVEELKAESKGK----VAFVGDGINDAPVLARADVGIAMGGLGSDAAIEA 529
                         650       660
                  ....*....|....*....|.
gi 569010236  823 SDIILTDDNFTSIVKAVMWGR 843
Cdd:cd07548   530 ADVVLMNDEPSKVAEAIKIAR 550
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
200-881 5.45e-16

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 82.79  E-value: 5.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  200 NGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLkIDESSLTGESDHVRksADKDPMLLSGTHVMEGSGRMVVTAV 279
Cdd:cd02092   134 DGSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSGTSE-LDRSLLTGESAPVT--VAPGDLVQAGAMNLSGPLRLRATAA 210
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  280 GvnsqtgiiftllgaggeeeekkdkkgkqqdgamdssqtrakkqDGAVAMEMQPLksaeggeMEEREKKKAnvpkkeksv 359
Cdd:cd02092   211 G-------------------------------------------DDTLLAEIARL-------MEAAEQGRS--------- 231
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  360 lqgKLTKLAVQIgkAGLVMSAITVIILVlyfvieTFVvdgrVWLAECTPVYVQyfvkfFIIGVTVLVVAVPEGLPLAVTI 439
Cdd:cd02092   232 ---RYVRLADRA--ARLYAPVVHLLALL------TFV----GWVAAGGDWRHA-----LLIAVAVLIITCPCALGLAVPA 291
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  440 SLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAPSALTPKildllvHAISIN 519
Cdd:cd02092   292 VQVVASGRLFRRGVLVKDGTALERLAEVDTVVFDKTGTLTLGSPRLVGAHAISADLLALAAALAQASR------HPLSRA 365
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  520 SAYTTkilppekeGALPRQVGNKTECAllGFVLDLKRDFQPVREQIPEDqlykvytfnsvrksMSTVIRMPDGGFRLFSK 599
Cdd:cd02092   366 LAAAA--------GARPVELDDAREVP--GRGVEGRIDGARVRLGRPAW--------------LGASAGVSTASELALSK 421
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  600 GASEillkkctnilnsngelrgfrprdrddmvkkiiepmacdglrticiayrdfsaiqepdwdnenevvgdltcIAVVGI 679
Cdd:cd02092   422 GGEE----------------------------------------------------------------------AARFPF 431
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  680 EDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQpgedflclegkefnrrirnekgeieqerldkvwpkl 759
Cdd:cd02092   432 EDRPRPDAREAISALRALGLSVEILSGDREPAVRALARALGIED------------------------------------ 475
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  760 rVLARSSPTDKHTLvkgiIDSTTGEQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTSIVKAV 839
Cdd:cd02092   476 -WRAGLTPAEKVAR----IEELKAQGRRVLMV-GDGLNDAPALAAAHVSMAPASA-VDASRSAADIVFLGDSLAPVPEAI 548
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|..
gi 569010236  840 MWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacitQDSPLKA 881
Cdd:cd02092   549 EIARRARRLIRQNFALAIGYNVIAVPLAIAG----YVTPLIA 586
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
200-871 6.44e-16

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 83.01  E-value: 6.44e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   200 NGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNdLKIDESSLTGESDHVRKSADKD-PMLLSGTHVMegSGRMVVTa 278
Cdd:TIGR01497  113 DGAIDKVPADQLKKGDIVLVEAGDVIPCDGEVIEGV-ASVDESAITGESAPVIKESGGDfASVTGGTRIL--SDWLVVE- 188
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   279 VGVNSQTGIIftllgaggeeeekkdkkgkqqdgamdssqtrakkqDGAVAMemqplksAEGGEmeeREKKKANVpkkeks 358
Cdd:TIGR01497  189 CTANPGETFL-----------------------------------DRMIAL-------VEGAQ---RRKTPNEI------ 217
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   359 vlqgKLTKLAVqigkaglVMSAITVIILVLYFVIETFVvdgrvwlaeCTPVYVQyfvkffiIGVTVLVVAVPE---GLPL 435
Cdd:TIGR01497  218 ----ALTILLI-------ALTLVFLLVTATLWPFAAYG---------GNAISVT-------VLVALLVCLIPTtigGLLS 270
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   436 AVTISlaySVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTtnrmtvvqsyLGDTHYKE-IPAPSALTPKILDllvh 514
Cdd:TIGR01497  271 AIGIA---GMDRVLGFNVIATSGRAVEACGDVDTLLLDKTGTIT----------LGNRLASEfIPAQGVDEKTLAD---- 333
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   515 aisinSAYTTKILPPEKEGALPRQVGNKtecalLGFVLDLKRDFQPVREQIpedqlykvytfnSVRKSMSTvIRMPDGgf 594
Cdd:TIGR01497  334 -----AAQLASLADDTPEGKSIVILAKQ-----LGIREDDVQSLHATFVEF------------TAQTRMSG-INLDNG-- 388
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   595 RLFSKGASEILLKKCTnilnsngELRGFRPRDRDDMVKKIIE----PMAcdglrtICIayrdfsaiqepdwdnENEVVGd 670
Cdd:TIGR01497  389 RMIRKGAVDAIKRHVE-------ANGGHIPTDLDQAVDQVARqggtPLV------VCE---------------DNRIYG- 439
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   671 ltciaVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgEDFLclegkefnrrirnekgeieqe 750
Cdd:TIGR01497  440 -----VIYLKDIVKGGIKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGV----DDFI--------------------- 489
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   751 rldkvwpklrvlARSSPTDKHTLVKGIIDsttgeQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDD 830
Cdd:TIGR01497  490 ------------AEATPEDKIALIRQEQA-----EGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAANMVDLDS 551
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*
gi 569010236   831 NFTSIVKAVMWGRNVYDSISKFLQFQLTVNVV---AVI-VAFTGA 871
Cdd:TIGR01497  552 DPTKLIEVVHIGKQLLITRGALTTFSIANDVAkyfAIIpAIFAAA 596
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
196-828 8.33e-16

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 82.73  E-value: 8.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  196 TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGnDLKIDESSLTGESDHV-RKSADKdpmllsgthVMEGSgrM 274
Cdd:PRK11033  246 TRLRDGEREEVAIADLRPGDVIEVAAGGRLPADGKLLSP-FASFDESALTGESIPVeRATGEK---------VPAGA--T 313
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  275 VVtavgvnsqtgiiftllgaggeeeekkdkkgkqqdgamdssqtrakkqDGAVAMEMqplkSAEGGE---------MEER 345
Cdd:PRK11033  314 SV-----------------------------------------------DRLVTLEV----LSEPGAsaidrilhlIEEA 342
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  346 EKKKAnvPkkeksvLQGKLTKLAVQIGKAGLVMSAITVIILVLYFvietfvvdGRVWLaecTPVYVqyfvkffiiGVTVL 425
Cdd:PRK11033  343 EERRA--P------IERFIDRFSRIYTPAIMLVALLVILVPPLLF--------AAPWQ---EWIYR---------GLTLL 394
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  426 VVAVPEGL----PLAVTISLAYSVKKmmkdNNLVRHLDACETMGNATAICSDKTGTLT--TNRMTVVQSYLGdthykeIP 499
Cdd:PRK11033  395 LIGCPCALvistPAAITSGLAAAARR----GALIKGGAALEQLGRVTTVAFDKTGTLTegKPQVTDIHPATG------IS 464
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  500 APSALTpkildlLVHAISINSAYttkilpPekegaLPRQVGNKTECALLGFVLDLKRDFQP---VREQIpEDQLYKVYTf 576
Cdd:PRK11033  465 ESELLA------LAAAVEQGSTH------P-----LAQAIVREAQVRGLAIPEAESQRALAgsgIEGQV-NGERVLICA- 525
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  577 nsvrksmstvirmPDGGFRLFSKGASEILLkkctniLNSNGElrgfrprdrddmvkkiiepmacdglrTICIAYRDfsai 656
Cdd:PRK11033  526 -------------PGKLPPLADAFAGQINE------LESAGK--------------------------TVVLVLRN---- 556
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  657 qepdwdneNEVVGdltciaVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgeDFlclegkef 736
Cdd:PRK11033  557 --------DDVLG------LIALQDTLRADARQAISELKALGIKGVMLTGDNPRAAAAIAGELGI-----DF-------- 609
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  737 nrrirnekgeieqerldkvwpklrvlaRSS--PTDKhtlVKGIIDSTtgeQRQVVAVTGDGTNDGPALKKADVGFAMGiA 814
Cdd:PRK11033  610 ---------------------------RAGllPEDK---VKAVTELN---QHAPLAMVGDGINDAPAMKAASIGIAMG-S 655
                         650
                  ....*....|....
gi 569010236  815 GTDVAKEASDIILT 828
Cdd:PRK11033  656 GTDVALETADAALT 669
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
51-120 3.70e-15

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 71.05  E-value: 3.70e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236    51 EAYGDVSGLCRRLKTSPTEGLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIV 120
Cdd:pfam00690    1 WHALSVEEVLKKLGTDLEKGL--TEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
214-881 3.81e-14

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 77.17  E-value: 3.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  214 GDIAQVKYGDLLPADGVLIQGNdLKIDESSLTGESDHVRK-SADKDPmllSGTHVMEGSGRMVVTAVGVNSQTGIIFTll 292
Cdd:cd07553   149 GDVYLVASGQRVPVDGKLLSEQ-ASIDMSWLTGESLPRIVeRGDKVP---AGTSLENQAFEIRVEHSLAESWSGSILQ-- 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  293 gaggeeeekkdkkgkqqdgamdssqtrakkqdgavamemqplksaeggEMEEREKKKAnvpkkeksvlqgKLTKLAVQIG 372
Cdd:cd07553   223 ------------------------------------------------KVEAQEARKT------------PRDLLADKII 242
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  373 kaglvmSAITVIILVLYFVIETFvvdgrvWLAECTPVYVQYFVkffiigvTVLVVAVPEGLPLAVTISLAYSVKKMMKDN 452
Cdd:cd07553   243 ------HYFTVIALLIAVAGFGV------WLAIDLSIALKVFT-------SVLIVACPCALALATPFTDEIALARLKKKG 303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  453 NLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSylgdthykeipAPSALTpkiLDLLVHAISInsayttkilppekE 532
Cdd:cd07553   304 VLIKNASSLERLSRVRTIVFDKTGTLTRGKSSFVMV-----------NPEGID---RLALRAISAI-------------E 356
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  533 GALPRQVGNktecallgfvldLKRDFQPVREqipedqlykvytfnSVRKSMSTVIRMPDGGFRLFSKGaSEILLKKCtni 612
Cdd:cd07553   357 AHSRHPISR------------AIREHLMAKG--------------LIKAGASELVEIVGKGVSGNSSG-SLWKLGSA--- 406
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  613 lnsngelrgfrprdrddmvkkiiePMACDGLRTICIAYRDFSAIqepdwdnenevvgdltciAVVGIEDPVRPEVPEAIR 692
Cdd:cd07553   407 ------------------------PDACGIQESGVVIARDGRQL------------------LDLSFNDLLRPDSNREIE 444
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  693 KCQRAGITVRMVTGDNINTARAIAAKCGiiqpgedflclegkefnrrirnekgeieqerLDKVwpklRVLARSSPTDKHT 772
Cdd:cd07553   445 ELKKGGLSIAILSGDNEEKVRLVGDSLG-------------------------------LDPR----QLFGNLSPEEKLA 489
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  773 LVKgiidstTGEQRQVVAVtGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKF 852
Cdd:cd07553   490 WIE------SHSPENTLMV-GDGANDALALASAFVGIAVA-GEVGVSLEAADIYYAGNGIGGIRDLLTLSKQTIKAIKGL 561
                         650       660
                  ....*....|....*....|....*....
gi 569010236  853 LQFQLTVNVVAVIVAFTGACitqdSPLKA 881
Cdd:cd07553   562 FAFSLLYNLVAIGLALSGWI----SPLVA 586
copA PRK10671
copper-exporting P-type ATPase CopA;
206-839 4.23e-14

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 77.47  E-value: 4.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  206 VPVAALVVGDIAQVKYGDLLPADGVLIQGnDLKIDESSLTGESDHVRKSADKDpmLLSGTHVMEGSgrMVVTAVGVNSQT 285
Cdd:PRK10671  336 VPLADVQPGMLLRLTTGDRVPVDGEITQG-EAWLDEAMLTGEPIPQQKGEGDS--VHAGTVVQDGS--VLFRASAVGSHT 410
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  286 G---IIftllgaggeeeekkdkkgkqqdgamdssqtrakkqdgavamemqplksaeggemeerekkkanvpkkeKSVLQG 362
Cdd:PRK10671  411 TlsrII--------------------------------------------------------------------RMVRQA 422
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  363 KLTKlaVQIGKAGLVMSAITVIILVLYFVIEtfvvdGRVWlaectpvyvqYF-------VKFFIIGVTVLVVAVPEGLPL 435
Cdd:PRK10671  423 QSSK--PEIGQLADKISAVFVPVVVVIALVS-----AAIW----------YFfgpapqiVYTLVIATTVLIIACPCALGL 485
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  436 AVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT--TNRMTVVQSYLGDTHYKEIPAPSALTPKILDLLV 513
Cdd:PRK10671  486 ATPMSIISGVGRAAEFGVLVRDADALQRASTLDTLVFDKTGTLTegKPQVVAVKTFNGVDEAQALRLAAALEQGSSHPLA 565
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  514 HAISINSAYTTkiLPPEKEGALPRQVGNKTECAllGFVLDLKRDFQPVREQIPEDqlykvytfnsvrkSMSTVIRmpdgg 593
Cdd:PRK10671  566 RAILDKAGDMT--LPQVNGFRTLRGLGVSGEAE--GHALLLGNQALLNEQQVDTK-------------ALEAEIT----- 623
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  594 fRLFSKGASEILLkkctnilnsngelrgfrprdrddmvkkiiepmACDGlrticiayrdfsaiqepdwdnenevvgdlTC 673
Cdd:PRK10671  624 -AQASQGATPVLL--------------------------------AVDG-----------------------------KA 641
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  674 IAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQpgedflclegkefnrrirnekgeieqerld 753
Cdd:PRK10671  642 AALLAIRDPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGIDE------------------------------ 691
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  754 kvwpklrVLARSSPTDKHTLVKgiidsTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFT 833
Cdd:PRK10671  692 -------VIAGVLPDGKAEAIK-----RLQSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSDVAIETAAITLMRHSLM 758

                  ....*.
gi 569010236  834 SIVKAV 839
Cdd:PRK10671  759 GVADAL 764
PLN03190 PLN03190
aminophospholipid translocase; Provisional
418-715 6.57e-12

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 70.31  E-value: 6.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  418 FIIGVTVLVVAVPEGLPLA---VTISLAYSvkkMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTTNRMT 484
Cdd:PLN03190  394 FLMSVIVFQIMIPISLYISmelVRVGQAYF---MIRDDQMydeasnsrfqCRALNINEDLGQIKYVFSDKTGTLTENKME 470
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  485 VVQSYLGDTHYKEIPAPS----------------------ALTPKILDLL-----------VHAISINSAYTTKILP--- 528
Cdd:PLN03190  471 FQCASIWGVDYSDGRTPTqndhagysvevdgkilrpkmkvKVDPQLLELSksgkdteeakhVHDFFLALAACNTIVPivv 550
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  529 ----------PEKEGALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDQLYKV---YTFNSVRKSMSTVIRMPDGGFR 595
Cdd:PLN03190  551 ddtsdptvklMDYQGESPDEQALVYAAAAYGFMLIERTSGHIVIDIHGERQRFNVlglHEFDSDRKRMSVILGCPDKTVK 630
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  596 LFSKGASEILLKKCTNILNSN------GELRGFrprdrddmvkkiiepmACDGLRTICIAYRDFSAIQEPDWDNENE--- 666
Cdd:PLN03190  631 VFVKGADTSMFSVIDRSLNMNvirateAHLHTY----------------SSLGLRTLVVGMRELNDSEFEQWHFSFEaas 694
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569010236  667 --VVG--------------DLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAI 715
Cdd:PLN03190  695 taLIGraallrkvasnvenNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISI 759
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
59-124 4.47e-11

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 59.90  E-value: 4.47e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569010236     59 LCRRLKTSPTEGLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGL 124
Cdd:smart00831   12 VLERLQTDLEKGL--SSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
664-861 1.74e-10

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 65.49  E-value: 1.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  664 ENEVVgdltcIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIqpgedflclegkefnrrirne 743
Cdd:PRK14010  428 EDNEI-----LGVIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGVD--------------------- 481
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  744 kgeieqerldkvwpklRVLARSSPTDKHTLVKgiidsTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEAS 823
Cdd:PRK14010  482 ----------------RFVAECKPEDKINVIR-----EEQAKGHIVAMTGDGTNDAPALAEANVGLAMN-SGTMSAKEAA 539
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 569010236  824 DIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNV 861
Cdd:PRK14010  540 NLIDLDSNPTKLMEVVLIGKQLLMTRGSLTTFSIANDI 577
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
664-806 4.88e-08

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 54.51  E-value: 4.88e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   664 ENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDFLCLEGKEFnrrirne 743
Cdd:pfam00702   80 LTVVLVELLGVIALADELKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDVGV------- 152
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569010236   744 kgeieqerldkvwpklrvlARSSPTDKHTLVKGIidsttGEQRQVVAVTGDGTNDGPALKKAD 806
Cdd:pfam00702  153 -------------------GKPKPEIYLAALERL-----GVKPEEVLMVGDGVNDIPAAKAAG 191
Pglycolate_arch TIGR01487
phosphoglycolate phosphatase, TA0175-type; This group of Archaeal sequences, now known to be ...
685-839 7.71e-06

phosphoglycolate phosphatase, TA0175-type; This group of Archaeal sequences, now known to be phosphoglycolate phosphatases, is most closely related to the sucrose-phosphate phosphatases from plants and cyanobacteria (TIGR01485). Together, these two models comprise a subfamily model (TIGR01482). TIGR01482, in turn, is a member of the IIB subfamily (TIGR01484) of the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases.


Pssm-ID: 273652 [Multi-domain]  Cd Length: 215  Bit Score: 48.20  E-value: 7.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   685 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQP--GED-----------FLCLEGKEFNRRIRNEKGEIeQER 751
Cdd:TIGR01487   21 ERAIEAIRKAEKKGIPVSLVTGNTVPFARALAVLIGTSGPvvAENggvifynkediFLANMEEEWFLDEEKKKRFP-RDR 99
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   752 LDKVWP---------------------KLRVLARSSPTDKHTLVKGI--------IDSTTGEQRQVVAVTGDGTNDGPAL 802
Cdd:TIGR01487  100 LSNEYPraslvimregkdvdevreiikERGLNLVASGFAIHIMKKGVdkgvgvekLKELLGIKPEEVAAIGDSENDIDLF 179
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 569010236   803 KKADVGFAMGIAgTDVAKEASDIILTDDNFTSIVKAV 839
Cdd:TIGR01487  180 RVVGFKVAVANA-DDQLKEIADYVTSNPYGEGVVEVL 215
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
685-831 7.28e-05

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 45.13  E-value: 7.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  685 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPgedFLCLEGKEfnrrIRNEKGE------IEQERLDKVWPK 758
Cdd:COG0561    22 PRTKEALRRLREKGIKVVIATGRPLRSALPLLEELGLDDP---LITSNGAL----IYDPDGEvlyerpLDPEDVREILEL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236  759 LR-------VLARSSPT---------DK----HTLVK--GIidsttgEQRQVVAVtGDGTNDGPALKKADVGFAMGIAgT 816
Cdd:COG0561    95 LRehglhlqVVVRSGPGfleilpkgvSKgsalKKLAErlGI------PPEEVIAF-GDSGNDLEMLEAAGLGVAMGNA-P 166
                         170
                  ....*....|....*
gi 569010236  817 DVAKEASDIIlTDDN 831
Cdd:COG0561   167 PEVKAAADYV-TGSN 180
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
789-831 9.40e-04

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 42.64  E-value: 9.40e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 569010236   789 VAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 831
Cdd:TIGR00099  207 VIAFGDGMNDIEMLEAAGYGVAMGNA-DEELKALADYV-TDSN 247
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
740-838 2.06e-03

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 41.45  E-value: 2.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   740 IRNEKGEIEQ--ERLDKVWPKLRVLARSSP---------TDKHTLVKGIIDSTTGEQRQVVAVtGDGTNDGPALKKADVG 808
Cdd:pfam08282  147 ILLDEEDLDEleKELKELFGSLITITSSGPgyleimpkgVSKGTALKALAKHLNISLEEVIAF-GDGENDIEMLEAAGLG 225
                           90       100       110
                   ....*....|....*....|....*....|
gi 569010236   809 FAMGIAgTDVAKEASDIILTDDNFTSIVKA 838
Cdd:pfam08282  226 VAMGNA-SPEVKAAADYVTDSNNEDGVAKA 254
HAD-SF-IB TIGR01488
Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; This model ...
682-805 3.58e-03

Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; This model represents a subfamily of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. Subfamily IA, B, C and D are distinguished from the rest of the superfamily by the presence of a variable domain between the first and second conserved catalytic motifs. In subfamilies IA and IB, this domain consists of an alpha-helical bundle. It was necessary to model these two subfamilies separately, breaking them at a an apparent phylogenetic bifurcation, so that the resulting model(s) are not so broadly defined that members of subfamily III (which lack the variable domain) are included. Subfamily IA includes the enzyme phosphoserine phosphatase (TIGR00338) as well as three hypothetical equivalogs. Many members of these hypothetical equivalogs have been annotated as PSPase-like or PSPase-family proteins. In particular, the hypothetical equivalog which appears to be most closely related to PSPase contains only Archaea (while TIGR00338 contains only eukaryotes and bacteria) of which some are annotated as PSPases. Although this is a reasonable conjecture, none of these sequences has sufficient evidence for this assignment. If such should be found, this model should be retired while the PSPase model should be broadened to include these sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273653 [Multi-domain]  Cd Length: 177  Bit Score: 39.64  E-value: 3.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010236   682 PVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgEDFLC--LEGKEFNRRIRNEKGEIEQERLDKVwPKL 759
Cdd:TIGR01488   73 ALRPGARELISWLKERGIDTVIVSGGFDFFVEPVAEKLGI----DDVFAnrLEFDDNGLLTGPIEGQVNPEGECKG-KVL 147
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 569010236   760 RVLARSSPTDKhtlvkgiidsttgeqRQVVAVtGDGTNDGPALKKA 805
Cdd:TIGR01488  148 KELLEESKITL---------------KKIIAV-GDSVNDLPMLKLA 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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