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Conserved domains on  [gi|568908306|ref|XP_006529280|]
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protein crumbs homolog 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 452-587 3.91e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 95.95  E-value: 3.91e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306   452 FHTVQPNALLLIRGN-KDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALvggsckEKC 529
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV------DGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568908306   530 TTKSSVPVENHQSICALQDSFLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 587
Cdd:pfam02210   75 TVVSSLPPGESLLLNLNGPLYLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 681-798 5.47e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 84.39  E-value: 5.47e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306   681 VRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFF----LSDGNVHLISLRIKPNEIELYQSSQNLGFIS 756
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSsgknLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 568908306   757 VPTW--TIRRGDVIFIGGLP--DREKTEVYGGFFKGCVQDVRLNSQ 798
Cdd:pfam02210   81 PPGEslLLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 918-1043 3.49e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 76.30  E-value: 3.49e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306   918 FRTHDTNVMILHAE-KEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLvNDGTWHQVTFSMidpvaQTSRWQMEVNDQ 996
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNL-NDGQWHSVRVER-----NGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568908306   997 TpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGGI 1043
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 224-259 1.01e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.01e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568908306  224 IDECRSQ-PCLHGATCQDAPGGYSCDCAPGFLGEHCE 259
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 147-182 1.16e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.16e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568908306  147 DHNECAS-SPCHNGAMCQDGINGYSCFCVPGYQGRHC 182
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 262-298 7.94e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 7.94e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568908306  262 VNECESQ-PCLHGGLCVDGRNSYHCDCTgSGFTGMHCE 298
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 186-221 8.18e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.18e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568908306  186 VDECVS-DPCKNEAVCLNEIGRYTCVCPQEFSGVNCE 221
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
335-376 1.07e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.07e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568908306    335 DVDECLL-HPCLNGGTCENLPGNYACHCPfddtsRTFYGGENC 376
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1235-1271 2.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.00e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568908306 1235 DINECAS-DPCINGGLCRDLVNRFLCICDVAFAGERCE 1271
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 614-645 1.51e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.51e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568908306  614 CESQ-PCQNRGRCINLWQGYQCECDRPYTGSNC 645
Cdd:cd00054     5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1079-1113 2.73e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 2.73e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568908306 1079 NACHS-SPCLHGGNCEDSYSSYRCACLSGWSGTHCE 1113
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1115-1150 2.98e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 2.98e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568908306 1115 NIDECFS-SPC-IHGNCSDGVAAYHCRCEPGYTGVNCE 1150
Cdd:cd00054     1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 113-143 1.47e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.47e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568908306   113 CGGNLCQHGGTCRKDPEHPVCICPPGYAGRF 143
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1152-1187 2.57e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 2.57e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568908306 1152 DVDNCKS-HQCANGATCVPEAHGYSCLCFGNFTGRFC 1187
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 827-861 3.70e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568908306  827 NTCKS-NPCHNGGVCHSLWDDFSCSCPTNTAGRACE 861
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
308-329 4.76e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 4.76e-03
                            10        20
                    ....*....|....*....|..
gi 568908306    308 PCHNDATCEDTVDSYICHCRPG 329
Cdd:smart00179   10 PCQNGGTCVNTVGSYRCECPPG 31
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 452-587 3.91e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 95.95  E-value: 3.91e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306   452 FHTVQPNALLLIRGN-KDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALvggsckEKC 529
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV------DGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568908306   530 TTKSSVPVENHQSICALQDSFLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 587
Cdd:pfam02210   75 TVVSSLPPGESLLLNLNGPLYLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 681-798 5.47e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 84.39  E-value: 5.47e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306   681 VRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFF----LSDGNVHLISLRIKPNEIELYQSSQNLGFIS 756
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSsgknLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 568908306   757 VPTW--TIRRGDVIFIGGLP--DREKTEVYGGFFKGCVQDVRLNSQ 798
Cdd:pfam02210   81 PPGEslLLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 423-587 2.05e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.84  E-value: 2.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306  423 TLSFGSNGFLWVTSGSHTGigPECNISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVwNQLKVLLSISHNT 500
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPR--TRLSISFSFRTTSPNGLLLYAGSQNGGdfLALELEDGRLVLRYDL-GSGSLVLSSKTPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306  501 SDGEWHFVEVTI-AETLTLALVGGSCKEKCTTKSSVPVENHQSIcalqdsFLGGLPMGTANNSVsvlniynvPSTPSFVG 579
Cdd:cd00110    78 NDGQWHSVSVERnGRSVTLSVDGERVVESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGFVG 143


                  ....*...
gi 568908306  580 CLQDIRFD 587
Cdd:cd00110   144 CIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 918-1043 3.49e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 76.30  E-value: 3.49e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306   918 FRTHDTNVMILHAE-KEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLvNDGTWHQVTFSMidpvaQTSRWQMEVNDQ 996
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNL-NDGQWHSVRVER-----NGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568908306   997 TpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGGI 1043
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 658-796 4.49e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.91  E-value: 4.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306  658 DSTGYAAFSVNDNYGQNFSLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ---TPGSPKFMVNFFLSDGNVHL 733
Cdd:cd00110     5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLRydlGSGSLVLSSKTPLNDGQWHS 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568908306  734 ISLRIKPNEIEL-------YQSSQNLGFISVPTwtirrGDVIFIGGLPDREKT--EVYGGFFKGCVQDVRLN 796
Cdd:cd00110    85 VSVERNGRSVTLsvdgervVESGSPGGSALLNL-----DGPLYLGGLPEDLKSpgLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 890-1040 6.35e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 6.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306  890 AVFSGLSReILFRSNGNITRElTNITFAFRTHDTNVMILHAEKEP--EFLNISIQDARLFFQLRSGNSfyTLHLMGSQLV 967
Cdd:cd00110     2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306  968 NDGTWHQVTFSMIDPVAqtsrwQMEVNDQTpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEI 1040
Cdd:cd00110    78 NDGQWHSVSVERNGRSV-----TLSVDGER--VVESGSPGGSALLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
913-1042 5.42e-13

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 67.36  E-value: 5.42e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306    913 NITFAFRTHDTNVMILHA--EKEPEFLNISIQDARLFFQLRSGNSFYTLHLmGSQLVNDGTWHQVTFSMIDPVAqtsrwQ 990
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNGRSV-----T 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 568908306    991 MEVNDQTPfvISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGG 1042
Cdd:smart00282   75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
447-587 1.80e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 65.82  E-value: 1.80e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306    447 NISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLalvgg 523
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGdyLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERnGRSVTL----- 75

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568908306    524 sckekcttksSVPVENHQSICALQDS---------FLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 587
Cdd:smart00282   76 ----------SVDGGNRVSGESPGGLtilnldgplYLGGLP--------EDLKLPPLPVTPGFRGCIRNLKVN 130
LamG smart00282
Laminin G domain;
676-798 1.99e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 60.05  E-value: 1.99e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306    676 SLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ--TPGSPKFMVNFF--LSDGNVHLISLRIKPNEIELY--QS 748
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRydLGSGPARLTSDPtpLNDGQWHRVAVERNGRSVTLSvdGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568908306    749 SQNLGFISVPTWTIRRGDVIFIGGLPD--REKTEVYGGFFKGCVQDVRLNSQ 798
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 224-259 1.01e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.01e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568908306  224 IDECRSQ-PCLHGATCQDAPGGYSCDCAPGFLGEHCE 259
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 147-182 1.16e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.16e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568908306  147 DHNECAS-SPCHNGAMCQDGINGYSCFCVPGYQGRHC 182
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
223-259 1.68e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.68e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568908306    223 EIDECRS-QPCLHGATCQDAPGGYSCDCAPGF-LGEHCE 259
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
147-183 1.91e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.91e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568908306    147 DHNECAS-SPCHNGAMCQDGINGYSCFCVPGYQ-GRHCD 183
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 262-298 7.94e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 7.94e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568908306  262 VNECESQ-PCLHGGLCVDGRNSYHCDCTgSGFTGMHCE 298
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 186-221 8.18e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.18e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568908306  186 VDECVS-DPCKNEAVCLNEIGRYTCVCPQEFSGVNCE 221
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
335-376 1.07e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.07e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568908306    335 DVDECLL-HPCLNGGTCENLPGNYACHCPfddtsRTFYGGENC 376
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1235-1271 2.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.00e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568908306 1235 DINECAS-DPCINGGLCRDLVNRFLCICDVAFAGERCE 1271
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 335-362 6.49e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 6.49e-05
                          10        20
                  ....*....|....*....|....*....
gi 568908306  335 DVDECLL-HPCLNGGTCENLPGNYACHCP 362
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCP 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 227-257 1.45e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 1.45e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568908306   227 CRSQPCLHGATCQDAPGGYSCDCAPGFLGEH 257
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 614-645 1.51e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.51e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568908306  614 CESQ-PCQNRGRCINLWQGYQCECDRPYTGSNC 645
Cdd:cd00054     5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
262-298 1.76e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.76e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568908306    262 VNECES-QPCLHGGLCVDGRNSYHCDCtGSGFT-GMHCE 298
Cdd:smart00179    2 IDECASgNPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 151-181 2.04e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 2.04e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568908306   151 CASSPCHNGAMCQDGINGYSCFCVPGYQGRH 181
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
185-221 2.32e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.32e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568908306    185 EVDECVS-DPCKNEAVCLNEIGRYTCVCPQEFS-GVNCE 221
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1079-1113 2.73e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 2.73e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568908306 1079 NACHS-SPCLHGGNCEDSYSSYRCACLSGWSGTHCE 1113
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 614-644 2.79e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 2.79e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568908306   614 CESQPCQNRGRCINLWQGYQCECDRPYTGSN 644
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1115-1150 2.98e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 2.98e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568908306 1115 NIDECFS-SPC-IHGNCSDGVAAYHCRCEPGYTGVNCE 1150
Cdd:cd00054     1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1235-1271 5.25e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.25e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568908306   1235 DINECAS-DPCINGGLCRDLVNRFLCICDVAF-AGERCE 1271
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 113-143 1.47e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.47e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568908306   113 CGGNLCQHGGTCRKDPEHPVCICPPGYAGRF 143
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1152-1187 2.57e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 2.57e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568908306 1152 DVDNCKS-HQCANGATCVPEAHGYSCLCFGNFTGRFC 1187
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 827-861 3.70e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568908306  827 NTCKS-NPCHNGGVCHSLWDDFSCSCPTNTAGRACE 861
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 265-294 3.74e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.74e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568908306   265 CESQPCLHGGLCVDGRNSYHCDCTgSGFTG 294
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 829-858 4.21e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 4.21e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568908306   829 CKSNPCHNGGVCHSLWDDFSCSCPTNTAGR 858
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
308-329 4.76e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 4.76e-03
                            10        20
                    ....*....|....*....|..
gi 568908306    308 PCHNDATCEDTVDSYICHCRPG 329
Cdd:smart00179   10 PCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 115-145 4.78e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 4.78e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 568908306  115 GNLCQHGGTCRKDPEHPVCICPPGYAGRFCE 145
Cdd:cd00054     8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1239-1269 5.55e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 5.55e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568908306  1239 CASDPCINGGLCRDLVNRFLCICDVAFAGER 1269
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 308-333 7.02e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 7.02e-03
                          10        20
                  ....*....|....*....|....*....
gi 568908306  308 PCHNDATCEDTVDSYICHCRPG---IHCE 333
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGytgRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 339-362 7.90e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 7.90e-03
                           10        20
                   ....*....|....*....|....
gi 568908306   339 CLLHPCLNGGTCENLPGNYACHCP 362
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP 24
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 1119-1193 9.46e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 38.08  E-value: 9.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306 1119 CFSSPCIHGNCSDGVaayHCRCEPGYTGVNCE--VDVDNCKSHQCANGATCVPEAH------GYSCLCFGNFTGRFCRHS 1190
Cdd:PHA03099   53 CLHGDCIHARDIDGM---YCRCSHGYTGIRCQhvVLVDYQRSEKPNTTTSYIPSPGivlvlvGIIITCCLLSVYRFTRRT 129


                  ...
gi 568908306 1191 RLP 1193
Cdd:PHA03099  130 KLP 132
EGF_CA smart00179
Calcium-binding EGF-like domain;
1084-1113 9.88e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 9.88e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 568908306   1084 SPCLHGGNCEDSYSSYRCACLSGWS-GTHCE 1113
Cdd:smart00179    9 NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 452-587 3.91e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 95.95  E-value: 3.91e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306   452 FHTVQPNALLLIRGN-KDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALvggsckEKC 529
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV------DGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568908306   530 TTKSSVPVENHQSICALQDSFLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 587
Cdd:pfam02210   75 TVVSSLPPGESLLLNLNGPLYLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 681-798 5.47e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 84.39  E-value: 5.47e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306   681 VRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFF----LSDGNVHLISLRIKPNEIELYQSSQNLGFIS 756
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSsgknLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 568908306   757 VPTW--TIRRGDVIFIGGLP--DREKTEVYGGFFKGCVQDVRLNSQ 798
Cdd:pfam02210   81 PPGEslLLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 423-587 2.05e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.84  E-value: 2.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306  423 TLSFGSNGFLWVTSGSHTGigPECNISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVwNQLKVLLSISHNT 500
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPR--TRLSISFSFRTTSPNGLLLYAGSQNGGdfLALELEDGRLVLRYDL-GSGSLVLSSKTPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306  501 SDGEWHFVEVTI-AETLTLALVGGSCKEKCTTKSSVPVENHQSIcalqdsFLGGLPMGTANNSVsvlniynvPSTPSFVG 579
Cdd:cd00110    78 NDGQWHSVSVERnGRSVTLSVDGERVVESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGFVG 143


                  ....*...
gi 568908306  580 CLQDIRFD 587
Cdd:cd00110   144 CIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 918-1043 3.49e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 76.30  E-value: 3.49e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306   918 FRTHDTNVMILHAE-KEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLvNDGTWHQVTFSMidpvaQTSRWQMEVNDQ 996
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNL-NDGQWHSVRVER-----NGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568908306   997 TpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGGI 1043
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 658-796 4.49e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.91  E-value: 4.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306  658 DSTGYAAFSVNDNYGQNFSLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ---TPGSPKFMVNFFLSDGNVHL 733
Cdd:cd00110     5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLRydlGSGSLVLSSKTPLNDGQWHS 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568908306  734 ISLRIKPNEIEL-------YQSSQNLGFISVPTwtirrGDVIFIGGLPDREKT--EVYGGFFKGCVQDVRLN 796
Cdd:cd00110    85 VSVERNGRSVTLsvdgervVESGSPGGSALLNL-----DGPLYLGGLPEDLKSpgLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 890-1040 6.35e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 6.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306  890 AVFSGLSReILFRSNGNITRElTNITFAFRTHDTNVMILHAEKEP--EFLNISIQDARLFFQLRSGNSfyTLHLMGSQLV 967
Cdd:cd00110     2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306  968 NDGTWHQVTFSMIDPVAqtsrwQMEVNDQTpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEI 1040
Cdd:cd00110    78 NDGQWHSVSVERNGRSV-----TLSVDGER--VVESGSPGGSALLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
913-1042 5.42e-13

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 67.36  E-value: 5.42e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306    913 NITFAFRTHDTNVMILHA--EKEPEFLNISIQDARLFFQLRSGNSFYTLHLmGSQLVNDGTWHQVTFSMIDPVAqtsrwQ 990
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNGRSV-----T 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 568908306    991 MEVNDQTPfvISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGG 1042
Cdd:smart00282   75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
447-587 1.80e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 65.82  E-value: 1.80e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306    447 NISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLalvgg 523
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGdyLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERnGRSVTL----- 75

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568908306    524 sckekcttksSVPVENHQSICALQDS---------FLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 587
Cdd:smart00282   76 ----------SVDGGNRVSGESPGGLtilnldgplYLGGLP--------EDLKLPPLPVTPGFRGCIRNLKVN 130
LamG smart00282
Laminin G domain;
676-798 1.99e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 60.05  E-value: 1.99e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306    676 SLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ--TPGSPKFMVNFF--LSDGNVHLISLRIKPNEIELY--QS 748
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRydLGSGPARLTSDPtpLNDGQWHRVAVERNGRSVTLSvdGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568908306    749 SQNLGFISVPTWTIRRGDVIFIGGLPD--REKTEVYGGFFKGCVQDVRLNSQ 798
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
918-1042 2.25e-09

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 56.94  E-value: 2.25e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306   918 FRTHDTNVMILHAEK--EPEFLNISIQDARLFFQLRSGNSfyTLHLMGSQLVNDGTWHQVTFSMIdpvaqTSRWQMEVND 995
Cdd:pfam00054    1 FRTTEPSGLLLYNGTqtERDFLALELRDGRLEVSYDLGSG--AAVVRSGDKLNDGKWHSVELERN-----GRSGTLSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568908306   996 QTPFVISEVaTGSLNFLKDNTDIYVG---DQSVDNP-----KGLQGCLSTIEIGG 1042
Cdd:pfam00054   74 EARPTGESP-LGATTDLDVDGPLYVGglpSLGVKKRrlaisPSFDGCIRDVIVNG 127
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 224-259 1.01e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.01e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568908306  224 IDECRSQ-PCLHGATCQDAPGGYSCDCAPGFLGEHCE 259
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 147-182 1.16e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.16e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568908306  147 DHNECAS-SPCHNGAMCQDGINGYSCFCVPGYQGRHC 182
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
223-259 1.68e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.68e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568908306    223 EIDECRS-QPCLHGATCQDAPGGYSCDCAPGF-LGEHCE 259
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
147-183 1.91e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.91e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568908306    147 DHNECAS-SPCHNGAMCQDGINGYSCFCVPGYQ-GRHCD 183
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Laminin_G_1 pfam00054
Laminin G domain;
452-587 4.29e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 47.31  E-value: 4.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306   452 FHTVQPNALLLIRG--NKDVSMKLELLNGCVHLSIEVWNQlKVLLSISHNTSDGEWHFVEVTIAET-LTLALVGGSckek 528
Cdd:pfam00054    1 FRTTEPSGLLLYNGtqTERDFLALELRDGRLEVSYDLGSG-AAVVRSGDKLNDGKWHSVELERNGRsGTLSVDGEA---- 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568908306   529 cTTKSSVPVENHQSICALQDSFLGGLPmgtannSVSVLNiYNVPSTPSFVGCLQDIRFD 587
Cdd:pfam00054   76 -RPTGESPLGATTDLDVDGPLYVGGLP------SLGVKK-RRLAISPSFDGCIRDVIVN 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 262-298 7.94e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 7.94e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568908306  262 VNECESQ-PCLHGGLCVDGRNSYHCDCTgSGFTGMHCE 298
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 186-221 8.18e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.18e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568908306  186 VDECVS-DPCKNEAVCLNEIGRYTCVCPQEFSGVNCE 221
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
335-376 1.07e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.07e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568908306    335 DVDECLL-HPCLNGGTCENLPGNYACHCPfddtsRTFYGGENC 376
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1235-1271 2.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.00e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568908306 1235 DINECAS-DPCINGGLCRDLVNRFLCICDVAFAGERCE 1271
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 335-362 6.49e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 6.49e-05
                          10        20
                  ....*....|....*....|....*....
gi 568908306  335 DVDECLL-HPCLNGGTCENLPGNYACHCP 362
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCP 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 227-257 1.45e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 1.45e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568908306   227 CRSQPCLHGATCQDAPGGYSCDCAPGFLGEH 257
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 614-645 1.51e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.51e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568908306  614 CESQ-PCQNRGRCINLWQGYQCECDRPYTGSNC 645
Cdd:cd00054     5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
262-298 1.76e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.76e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568908306    262 VNECES-QPCLHGGLCVDGRNSYHCDCtGSGFT-GMHCE 298
Cdd:smart00179    2 IDECASgNPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 151-181 2.04e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 2.04e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568908306   151 CASSPCHNGAMCQDGINGYSCFCVPGYQGRH 181
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
185-221 2.32e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.32e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568908306    185 EVDECVS-DPCKNEAVCLNEIGRYTCVCPQEFS-GVNCE 221
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1079-1113 2.73e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 2.73e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568908306 1079 NACHS-SPCLHGGNCEDSYSSYRCACLSGWSGTHCE 1113
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 614-644 2.79e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 2.79e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568908306   614 CESQPCQNRGRCINLWQGYQCECDRPYTGSN 644
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1115-1150 2.98e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 2.98e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568908306 1115 NIDECFS-SPC-IHGNCSDGVAAYHCRCEPGYTGVNCE 1150
Cdd:cd00054     1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1235-1271 5.25e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.25e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568908306   1235 DINECAS-DPCINGGLCRDLVNRFLCICDVAF-AGERCE 1271
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 226-259 9.39e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.84  E-value: 9.39e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568908306  226 ECR-SQPCLHGATCQDAPGGYSCDCAPGFLGE-HCE 259
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 113-143 1.47e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.47e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568908306   113 CGGNLCQHGGTCRKDPEHPVCICPPGYAGRF 143
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 150-182 1.70e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 1.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568908306  150 ECA-SSPCHNGAMCQDGINGYSCFCVPGYQG-RHC 182
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGdRSC 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1152-1187 2.57e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 2.57e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568908306 1152 DVDNCKS-HQCANGATCVPEAHGYSCLCFGNFTGRFC 1187
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Laminin_G_1 pfam00054
Laminin G domain;
681-801 2.96e-03

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 2.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306   681 VRTRQPLGLLLALENSTY-QYVSVWLEHGSL----------ALQTPGSPkfmvnffLSDGNVHLI---------SLRIKP 740
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErDFLALELRDGRLevsydlgsgaAVVRSGDK-------LNDGKWHSVelerngrsgTLSVDG 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568908306   741 NEIELYQS-SQNLGFISVPTwtirrgdVIFIGGLPDREKTE---VYGGFFKGCVQDVRLNSQTLE 801
Cdd:pfam00054   74 EARPTGESpLGATTDLDVDG-------PLYVGGLPSLGVKKrrlAISPSFDGCIRDVIVNGKPLD 131
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 827-861 3.70e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568908306  827 NTCKS-NPCHNGGVCHSLWDDFSCSCPTNTAGRACE 861
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 265-294 3.74e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.74e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568908306   265 CESQPCLHGGLCVDGRNSYHCDCTgSGFTG 294
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 829-858 4.21e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 4.21e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568908306   829 CKSNPCHNGGVCHSLWDDFSCSCPTNTAGR 858
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
308-329 4.76e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 4.76e-03
                            10        20
                    ....*....|....*....|..
gi 568908306    308 PCHNDATCEDTVDSYICHCRPG 329
Cdd:smart00179   10 PCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 115-145 4.78e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 4.78e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 568908306  115 GNLCQHGGTCRKDPEHPVCICPPGYAGRFCE 145
Cdd:cd00054     8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1239-1269 5.55e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 5.55e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568908306  1239 CASDPCINGGLCRDLVNRFLCICDVAFAGER 1269
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 308-333 7.02e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 7.02e-03
                          10        20
                  ....*....|....*....|....*....
gi 568908306  308 PCHNDATCEDTVDSYICHCRPG---IHCE 333
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGytgRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 339-362 7.90e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 7.90e-03
                           10        20
                   ....*....|....*....|....
gi 568908306   339 CLLHPCLNGGTCENLPGNYACHCP 362
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP 24
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 1119-1193 9.46e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 38.08  E-value: 9.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908306 1119 CFSSPCIHGNCSDGVaayHCRCEPGYTGVNCE--VDVDNCKSHQCANGATCVPEAH------GYSCLCFGNFTGRFCRHS 1190
Cdd:PHA03099   53 CLHGDCIHARDIDGM---YCRCSHGYTGIRCQhvVLVDYQRSEKPNTTTSYIPSPGivlvlvGIIITCCLLSVYRFTRRT 129


                  ...
gi 568908306 1191 RLP 1193
Cdd:PHA03099  130 KLP 132
EGF_CA smart00179
Calcium-binding EGF-like domain;
1084-1113 9.88e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 9.88e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 568908306   1084 SPCLHGGNCEDSYSSYRCACLSGWS-GTHCE 1113
Cdd:smart00179    9 NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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