|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
23-317 |
1.24e-78 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 265.69 E-value: 1.24e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 23 YTSSSDESEDGRKPRQ-SFNSRETLHEYNQELRRNYNSQSRK----------RKDVEKSTQEIEFCETPPTLCSGYHTDM 91
Cdd:pfam06484 13 YTSSSADSEECRVPTQkSYSSSETLKAFDHDSRMLYGNRVKDmvhkeadefsRQGQNFSLRELGICEPSPRHGLAYCTEM 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 92 hSVSRHGYQLEMGSDVDTETEGAASPDHALRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDME 171
Cdd:pfam06484 93 -GLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENGPPIPPSSSSSS 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 172 APAD--------------------SAQDMQSSPHNQFTFRPLPPPPPPPHACTCARKPP--------------------- 210
Cdd:pfam06484 172 PVEQhsppppslnenqrpllgnnaSHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPnfqnhsrlrtpppplppphkq 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 211 -----PTVDSLQRRSMTTRSQPS----PAAPAPPTSTQDSVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYP 281
Cdd:pfam06484 252 nqhhhPSINSLNRSSLTNRRNPSpaptASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKTGTGTTPLFCTASPGYP 331
|
330 340 350
....*....|....*....|....*....|....*.
gi 569009288 282 LTSNTVYSPPPRPLPRSTFSRPAFTFNKPYRCCNWK 317
Cdd:pfam06484 332 LTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1195-1526 |
3.17e-38 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 147.29 E-value: 3.17e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1195 PVALASGPDGSVYVGDF--NFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYY----LAMDPmSESLYLSDTNTRKVYKL 1268
Cdd:cd14953 25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGNLYVADTGNHRIRKI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1269 kslvetkDLSKNFEVVAGTGDQclpfdqsHCGDGGKASEASLNSPRGITVDRHGFIYFVDGT--MIRRIDENAVITTVIG 1346
Cdd:cd14953 104 -------TPDGVVSTLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVAG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1347 snglTSTQPLSCD-SGmdiTQVRLEWPTDLAVNPMDNsLYVLD--NNIVLQISENRRVRIIAGRPIHCQVPGIDhflvsk 1423
Cdd:cd14953 170 ----TGGAGYAGDgPA---TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTGTAGFSGDGG------ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1424 vAIHSTLESARAISVSHSGLLFIAETDErkvNRIQQVTTNGEISIIAGAPTDcdckidpncdcFSGDGGYAKDAKMKAPS 1503
Cdd:cd14953 236 -ATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNNPT 300
|
330 340
....*....|....*....|...
gi 569009288 1504 SLAVSPDGTLYVADLGNVRIRTI 1526
Cdd:cd14953 301 GVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2646-2723 |
1.52e-35 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 130.42 E-value: 1.52e-35
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569009288 2646 EEKNHVLEMARQRAVAQAWTQEQRRLQEGEEGTRVWTEGEKQQLLGTGRVQGYDGYFVLSVEQYLELSDSANNIHFMR 2723
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1489-2422 |
9.25e-31 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 133.34 E-value: 9.25e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1489 GDGGYAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISKNQAHLNDMNLYEIASPADQELYQFTVNGTHLHTMNLITRD 1568
Cdd:COG3209 119 VSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGAVTLATGLAGS 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1569 YVYNFTYNAEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTISSNGVLKRVSAQGYNLALMTYPGNTGLLATK 1648
Cdd:COG3209 199 ALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGASGAGLDAST 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1649 SNENGWTTVYEYDPEGHLTNATFPTGEVSSFHSDLEKLTKVALDTSNRENVLMSTNLTATSTIYILKQEN---TQSTYRV 1725
Cdd:COG3209 279 GTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTvggGGSLTLG 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1726 SPDGSLRVTFASGMEINLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHNRNLLSID 1805
Cdd:COG3209 359 GYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTG 438
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1806 FDHMTRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTFIQRGTWNEKMEYDQSGKIISRTWADGK 1885
Cdd:COG3209 439 GGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTTTTTAGARG 518
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1886 IWSYTYLEKSVMLLLHSQRRYIFEYDQSDCLLSVTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTL 1965
Cdd:COG3209 519 LVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTT 598
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1966 HLGTGRRVLYKYTKQARLSEILYDTTQVTLTYEESSGVIKTIHLMHDGFicTIRYRQTGPLIGRQIFRFSEEGLVNARFD 2045
Cdd:COG3209 599 TTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGT--GVTTTGTTTTRATGTTGTGTGVTAGLTTL 676
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 2046 YSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITTTVMKHTKIFNANGQVIEVQYEILKAIA 2125
Cdd:COG3209 677 ATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAG 756
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 2126 YWmTIQYDNMGRMVICDIRVGVDANITRYFYEYDADGQLQTVSVNDKIQWRYSYDLNGNINLLSHGNSARLTPL-----R 2200
Cdd:COG3209 757 AL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSGGGTDLqdrtyT 835
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 2201 YDLRDRITRLgeiqykmdEDGFLRQRGNDIFEYNSNGLLQKAYNkvSGWTVQYYYDGLGRRVASKSSLGQHLQFFYADLa 2280
Cdd:COG3209 836 YDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATD--PGTTESYTYDANGNLTSRTDGGTTTYTYDALGR- 904
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 2281 nPIRVTHlynhTSAEITSLYYDLQGHliamelssgeeyyvaCDNMGTPLAVFSSRGQVIKEILYTPYGDIYHDTYPDFEV 2360
Cdd:COG3209 905 -LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAAN 964
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569009288 2361 IIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNhhiwkqlnllpkP------FNLYSFENNYPVGKI 2422
Cdd:COG3209 965 PLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD------------PiglaggLNLYAYVGNNPVNYV 1020
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
801-826 |
2.43e-09 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 54.44 E-value: 2.43e-09
10 20
....*....|....*....|....*.
gi 569009288 801 CGDNLDNDGDGLTDCVDPDCCQQSNC 826
Cdd:NF033662 7 CSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1195-1524 |
6.55e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 59.65 E-value: 6.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1195 PVALASGPDGSVYVGDF--NFVRRIFPSGNSVsilelrnrdTRHSTSPAHKYY-LAMDPmSESLYLSDTNTRKVYKLksl 1271
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPATGEF---------TEYPLGGGSGPHgIAVDP-DGNLWFTDNGNNRIGRI--- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1272 veTKDlSKNFEVVAGTGDQCLPFdqshcgdggkaseaslnsprGITVDRHGFIYFVDGT--MIRRIDenavittviGSNG 1349
Cdd:COG4257 86 --DPK-TGEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLD---------PATG 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1350 LTSTQPLSCDSGMditqvrlewPTDLAVNPmDNSLYVLDNnivlqisENRRVRIIagrpihcqvpGIDHFLVSKVAIHST 1429
Cdd:COG4257 134 EVTEFPLPTGGAG---------PYGIAVDP-DGNLWVTDF-------GANAIGRI----------DPDTGTLTEYALPTP 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1430 LESARAISVSHSGLLFIAETDERKVNRIQqvTTNGEISIIAGAPTDcdckidpncdcfsgdggyakdakmKAPSSLAVSP 1509
Cdd:COG4257 187 GAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTVTEYPLPGGG------------------------ARPYGVAVDG 240
|
330
....*....|....*
gi 569009288 1510 DGTLYVADLGNVRIR 1524
Cdd:COG4257 241 DGRVWFAESGANRIV 255
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
528-719 |
3.21e-06 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 51.16 E-value: 3.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 528 DDCSTNCNGNGECISGHCH-----------------CFPGFLGPdcaRDSCpvlCGG----NGE----------YEKGHC 576
Cdd:pfam19232 10 DDCTPPCGGTQVCIDRQCKdntlacttdaqcgtcmtCVAGACTP---KASC---CGGvtcgAGQtcdaktntcvYVKGYC 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 577 VC-RNGWKGPECDVPEEQCIDPTCFGHGT---CIMGV-----------------CICV------------PGYKGEICEE 623
Cdd:pfam19232 84 SAdHPCPSGSACDTAKNACIAQPPYGPDSgkgCVRGFgawiweldpatnsgvwrCRCAngslynsahecsPLADQTLCAA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 624 EDcLDPMC------------------------SSHGICVK----GECHCSTGWGGVNCETplpicQEQCSGHGTFLLDTG 675
Cdd:pfam19232 164 EN-LDPNAlvpassvpafaaygwgnqpvlinkSTAGAAVPsplaGVCPCKPGWAGGSCTE-----DRTCNGRGTWNETTG 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 569009288 676 VCSCDPKWTGSDcstelctmECGSHGVCSRgicqceegWVGPTC 719
Cdd:pfam19232 238 QCACNIDFSGHN--------SCGDDNNCTS--------WTGPRC 265
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2344-2422 |
1.66e-05 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 45.18 E-value: 1.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 2344 YTPYGDIYHDTyPDFEVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNhhiwkqlnllpkPF------NLYSFENNY 2417
Cdd:TIGR03696 1 YDPYGEVLSES-GAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD------------PIglggglNLYAYVGNN 67
|
....*
gi 569009288 2418 PVGKI 2422
Cdd:TIGR03696 68 PVNWV 72
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1573-1688 |
3.44e-05 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 49.62 E-value: 3.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1573 FTYNAEGDLGAITSSNGNSVHIRRDAGGMPLwlvvpggqvywltISSNGVLKRvsAQGYNLAlmtypgntGLLATKSNEN 1652
Cdd:NF041261 602 YEYNAAGDLTAVITPDGNRSETQYDAWGKAV-------------STTQGGLTR--SMEYDAA--------GRITTLTNEN 658
|
90 100 110
....*....|....*....|....*....|....*..
gi 569009288 1653 GWTTVYEYDPEGHLTNATFPTGEVSSFHSDLE-KLTK 1688
Cdd:NF041261 659 GSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTgKLTQ 695
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
710-753 |
2.33e-04 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 40.68 E-value: 2.33e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 569009288 710 CEEGWVGPTCEeRSC--------HSHCAEHGQCkdgkcECSPGWEGDHCTIA 753
Cdd:pfam01414 1 CDENYYGSTCS-KFCrprddkfgHYTCDANGNK-----VCLPGWTGPYCDKP 46
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
650-793 |
2.97e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.51 E-value: 2.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 650 GVNCETPLPICQEQCsghgtflLDTgvcSCDPkwtgSDCSTelCTMECGSHGVCSRGICQCEEGWV--GPTC-EERS--- 723
Cdd:NF041328 18 GAVCPEGLSVCGGAC-------VDL---RSDP----SNCGA--CGVACGAGQTCVAGACGCGPGTVacGGACvDTASdpa 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569009288 724 ----CHSHCAEHGQCKDGKCecspgwegdhctiahyldavRDGCP-GLCFGNGRCT-LDQNGWHCvcqvGWSGTGC 793
Cdd:NF041328 82 hcgaCGAACAPGQVCEGGAC--------------------REACSeGLTRCGGACVdLATDPLHC----GACGVAC 133
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
23-317 |
1.24e-78 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 265.69 E-value: 1.24e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 23 YTSSSDESEDGRKPRQ-SFNSRETLHEYNQELRRNYNSQSRK----------RKDVEKSTQEIEFCETPPTLCSGYHTDM 91
Cdd:pfam06484 13 YTSSSADSEECRVPTQkSYSSSETLKAFDHDSRMLYGNRVKDmvhkeadefsRQGQNFSLRELGICEPSPRHGLAYCTEM 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 92 hSVSRHGYQLEMGSDVDTETEGAASPDHALRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDME 171
Cdd:pfam06484 93 -GLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENGPPIPPSSSSSS 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 172 APAD--------------------SAQDMQSSPHNQFTFRPLPPPPPPPHACTCARKPP--------------------- 210
Cdd:pfam06484 172 PVEQhsppppslnenqrpllgnnaSHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPnfqnhsrlrtpppplppphkq 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 211 -----PTVDSLQRRSMTTRSQPS----PAAPAPPTSTQDSVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYP 281
Cdd:pfam06484 252 nqhhhPSINSLNRSSLTNRRNPSpaptASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKTGTGTTPLFCTASPGYP 331
|
330 340 350
....*....|....*....|....*....|....*.
gi 569009288 282 LTSNTVYSPPPRPLPRSTFSRPAFTFNKPYRCCNWK 317
Cdd:pfam06484 332 LTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1195-1526 |
3.17e-38 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 147.29 E-value: 3.17e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1195 PVALASGPDGSVYVGDF--NFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYY----LAMDPmSESLYLSDTNTRKVYKL 1268
Cdd:cd14953 25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGNLYVADTGNHRIRKI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1269 kslvetkDLSKNFEVVAGTGDQclpfdqsHCGDGGKASEASLNSPRGITVDRHGFIYFVDGT--MIRRIDENAVITTVIG 1346
Cdd:cd14953 104 -------TPDGVVSTLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVAG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1347 snglTSTQPLSCD-SGmdiTQVRLEWPTDLAVNPMDNsLYVLD--NNIVLQISENRRVRIIAGRPIHCQVPGIDhflvsk 1423
Cdd:cd14953 170 ----TGGAGYAGDgPA---TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTGTAGFSGDGG------ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1424 vAIHSTLESARAISVSHSGLLFIAETDErkvNRIQQVTTNGEISIIAGAPTDcdckidpncdcFSGDGGYAKDAKMKAPS 1503
Cdd:cd14953 236 -ATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNNPT 300
|
330 340
....*....|....*....|...
gi 569009288 1504 SLAVSPDGTLYVADLGNVRIRTI 1526
Cdd:cd14953 301 GVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2646-2723 |
1.52e-35 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 130.42 E-value: 1.52e-35
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569009288 2646 EEKNHVLEMARQRAVAQAWTQEQRRLQEGEEGTRVWTEGEKQQLLGTGRVQGYDGYFVLSVEQYLELSDSANNIHFMR 2723
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1246-1527 |
6.07e-34 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 134.58 E-value: 6.07e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1246 LAMDPmSESLYLSDTNTRKVYKL--KSLVETkdlsknfevVAGTGDQclpfdqshcG-DGGKASEASLNSPRGITVDRHG 1322
Cdd:cd14953 28 VAVDA-AGNLYVADRGNHRIRKItpDGVVTT---------VAGTGTA---------GfADGGGAAAQFNTPSGVAVDAAG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1323 FIYFVDGT--MIRRIDENAVITTVIGsnglTSTQPLSCDSGMdiTQVRLEWPTDLAVNPMDNsLYVLD--NNIVLQISEN 1398
Cdd:cd14953 89 NLYVADTGnhRIRKITPDGVVSTLAG----TGTAGFSDDGGA--TAAQFNYPTGVAVDAAGN-LYVADtgNHRIRKITPD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1399 RRVRIIAGRPihcqVPGidhFLVSKVAIHSTLESARAISVSHSGLLFIAETDErkvNRIQQVTTNGEISIIAGAPTDCdc 1478
Cdd:cd14953 162 GVVTTVAGTG----GAG---YAGDGPATAAQFNNPTGVAVDAAGNLYVADRGN---HRIRKITPDGVVTTVAGTGTAG-- 229
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 569009288 1479 kidpncdcFSGDGGyAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTIS 1527
Cdd:cd14953 230 --------FSGDGG-ATAAQLNNPTGVAVDAAGNLYVADSGNHRIRKIT 269
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1489-2422 |
9.25e-31 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 133.34 E-value: 9.25e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1489 GDGGYAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISKNQAHLNDMNLYEIASPADQELYQFTVNGTHLHTMNLITRD 1568
Cdd:COG3209 119 VSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGAVTLATGLAGS 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1569 YVYNFTYNAEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTISSNGVLKRVSAQGYNLALMTYPGNTGLLATK 1648
Cdd:COG3209 199 ALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGASGAGLDAST 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1649 SNENGWTTVYEYDPEGHLTNATFPTGEVSSFHSDLEKLTKVALDTSNRENVLMSTNLTATSTIYILKQEN---TQSTYRV 1725
Cdd:COG3209 279 GTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTvggGGSLTLG 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1726 SPDGSLRVTFASGMEINLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHNRNLLSID 1805
Cdd:COG3209 359 GYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTG 438
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1806 FDHMTRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTFIQRGTWNEKMEYDQSGKIISRTWADGK 1885
Cdd:COG3209 439 GGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTTTTTAGARG 518
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1886 IWSYTYLEKSVMLLLHSQRRYIFEYDQSDCLLSVTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTL 1965
Cdd:COG3209 519 LVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTT 598
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1966 HLGTGRRVLYKYTKQARLSEILYDTTQVTLTYEESSGVIKTIHLMHDGFicTIRYRQTGPLIGRQIFRFSEEGLVNARFD 2045
Cdd:COG3209 599 TTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGT--GVTTTGTTTTRATGTTGTGTGVTAGLTTL 676
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 2046 YSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITTTVMKHTKIFNANGQVIEVQYEILKAIA 2125
Cdd:COG3209 677 ATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAG 756
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 2126 YWmTIQYDNMGRMVICDIRVGVDANITRYFYEYDADGQLQTVSVNDKIQWRYSYDLNGNINLLSHGNSARLTPL-----R 2200
Cdd:COG3209 757 AL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSGGGTDLqdrtyT 835
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 2201 YDLRDRITRLgeiqykmdEDGFLRQRGNDIFEYNSNGLLQKAYNkvSGWTVQYYYDGLGRRVASKSSLGQHLQFFYADLa 2280
Cdd:COG3209 836 YDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATD--PGTTESYTYDANGNLTSRTDGGTTTYTYDALGR- 904
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 2281 nPIRVTHlynhTSAEITSLYYDLQGHliamelssgeeyyvaCDNMGTPLAVFSSRGQVIKEILYTPYGDIYHDTYPDFEV 2360
Cdd:COG3209 905 -LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAAN 964
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569009288 2361 IIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNhhiwkqlnllpkP------FNLYSFENNYPVGKI 2422
Cdd:COG3209 965 PLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD------------PiglaggLNLYAYVGNNPVNYV 1020
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1283-1527 |
9.65e-30 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 122.64 E-value: 9.65e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1283 VVAGTGDqclpfdqSHCGDGGKASeASLNSPRGITVDRHGFIYFVDGT--MIRRIDENAVITTVIGsnglTSTQPLSCDS 1360
Cdd:cd14953 3 TVAGSGT-------AGFSGGGGTA-ARFNSPSGVAVDAAGNLYVADRGnhRIRKITPDGVVTTVAG----TGTAGFADGG 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1361 GmdiTQVRLEWPTDLAVNPMDNsLYVLD--NNIVLQISENRRVRIIAGRpihcqvpGIDHFLVSKVAIHSTLESARAISV 1438
Cdd:cd14953 71 G---AAAQFNTPSGVAVDAAGN-LYVADtgNHRIRKITPDGVVSTLAGT-------GTAGFSDDGGATAAQFNYPTGVAV 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1439 SHSGLLFIAETderKVNRIQQVTTNGEISIIAGAPTDcdckidpncdcFSGDGGYAKDAKMKAPSSLAVSPDGTLYVADL 1518
Cdd:cd14953 140 DAAGNLYVADT---GNHRIRKITPDGVVTTVAGTGGA-----------GYAGDGPATAAQFNNPTGVAVDAAGNLYVADR 205
|
....*....
gi 569009288 1519 GNVRIRTIS 1527
Cdd:cd14953 206 GNHRIRKIT 214
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1189-1526 |
4.28e-22 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 98.54 E-value: 4.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1189 NNKLFAPVALASGPDGSVYVGDF--NFVRRIFPSGNSVSILELRNRDTRHSTSPAHkyyLAMDPmSESLYLSDTNTRKVY 1266
Cdd:cd05819 4 PGELNNPQGIAVDSSGNIYVADTgnNRIQVFDPDGNFITSFGSFGSGDGQFNEPAG---VAVDS-DGNLYVADTGNHRIQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1267 KLkslvetkDLSKNFEVVAGTGDQclpfdqshcGDGGkaseasLNSPRGITVDRHGFIYFVDgTM---IRRIDENAVITT 1343
Cdd:cd05819 80 KF-------DPDGNFLASFGGSGD---------GDGE------FNGPRGIAVDSSGNIYVAD-TGnhrIQKFDPDGEFLT 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1344 VIGSNGLTSTQplscdsgmditqvrLEWPTDLAVNPmDNSLYVLDnnivlqiSENRRVRIIA--GRPIhcqvpgidhFLV 1421
Cdd:cd05819 137 TFGSGGSGPGQ--------------FNGPTGVAVDS-DGNIYVAD-------TGNHRIQVFDpdGNFL---------TTF 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1422 -SKVAIHSTLESARAISVSHSGLLFIAETDErkvNRIQqvttngeisiiagaptdcdcKIDPNCDCFSGDGGYA-KDAKM 1499
Cdd:cd05819 186 gSTGTGPGQFNYPTGIAVDSDGNIYVADSGN---NRVQ--------------------VFDPDGAGFGGNGNFLgSDGQF 242
|
330 340
....*....|....*....|....*..
gi 569009288 1500 KAPSSLAVSPDGTLYVADLGNVRIRTI 1526
Cdd:cd05819 243 NRPSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1310-1534 |
1.64e-18 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 88.14 E-value: 1.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1310 LNSPRGITVDRHGFIYFVDGTM--IRRIDENAVITTVIGSNGLTSTQplscdsgmditqvrLEWPTDLAVNPmDNSLYVL 1387
Cdd:cd05819 7 LNNPQGIAVDSSGNIYVADTGNnrIQVFDPDGNFITSFGSFGSGDGQ--------------FNEPAGVAVDS-DGNLYVA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1388 DnnivlqiSENRRVRII--AGRPI-HCQVPGIDhflvskvaiHSTLESARAISVSHSGLLFIAETDErkvNRIQQVTTNG 1464
Cdd:cd05819 72 D-------TGNHRIQKFdpDGNFLaSFGGSGDG---------DGEFNGPRGIAVDSSGNIYVADTGN---HRIQKFDPDG 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1465 EISIIAGAPTDCDCK--------IDPN-----CDC-------FSGDGGY--------AKDAKMKAPSSLAVSPDGTLYVA 1516
Cdd:cd05819 133 EFLTTFGSGGSGPGQfngptgvaVDSDgniyvADTgnhriqvFDPDGNFlttfgstgTGPGQFNYPTGIAVDSDGNIYVA 212
|
250
....*....|....*...
gi 569009288 1517 DLGNVRIRTISKNQAHLN 1534
Cdd:cd05819 213 DSGNNRVQVFDPDGAGFG 230
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1165-1395 |
1.31e-15 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 80.65 E-value: 1.31e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1165 VIATIMGNGHQRSVActncNGPAHNNKLFAPVALASGPDGSVYVGDF--NFVRRIFPSGNsvsilelrnrdtrhstspah 1242
Cdd:cd14953 163 VVTTVAGTGGAGYAG----DGPATAAQFNNPTGVAVDAAGNLYVADRgnHRIRKITPDGV-------------------- 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1243 kyylamdpmseslylsdtntrkvyklkslVETkdlsknfevVAGTGDQclPFdqshcGDGGKASEASLNSPRGITVDRHG 1322
Cdd:cd14953 219 -----------------------------VTT---------VAGTGTA--GF-----SGDGGATAAQLNNPTGVAVDAAG 253
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569009288 1323 FIYFVD---GTmIRRIDENAVITTVIGSnglTSTQPLSCDSGmdiTQVRLEWPTDLAVNPmDNSLYVLD--NNIVLQI 1395
Cdd:cd14953 254 NLYVADsgnHR-IRKITPAGVVTTVAGG---GAGFSGDGGPA---TSAQFNNPTGVAVDA-AGNLYVADtgNNRIRKI 323
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1302-1523 |
1.09e-09 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 61.91 E-value: 1.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1302 GGKASEAslNSPRGITVDRHGFIYFVD--GTMIRRIDENaviTTVIGSNGLTSTQPLScdsgmditqvrLEWPTDLAVNP 1379
Cdd:cd14956 100 GSGPGQF--NAPRGVAVDADGNLYVADfgNQRIQKFDPD---GSFLRQWGGTGIEPGS-----------FNYPRGVAVDP 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1380 mDNSLYVLDnnivlqiSENRRVriiagrpihcQVPGIDHFLVSKVAIHST----LESARAISVSHSGLLFIAETDErkvN 1455
Cdd:cd14956 164 -DGTLYVAD-------TYNDRI----------QVFDNDGAFLRKWGGRGTgpgqFNYPYGIAIDPDGNVFVADFGN---N 222
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569009288 1456 RIQQVTTNGEISIIAGAPTdcdckidpncdcfSGDGgyakdaKMKAPSSLAVSPDGTLYVADLGNVRI 1523
Cdd:cd14956 223 RIQKFTADGTFLTSWGSPG-------------TGPG------QFKNPWGVVVDADGTVYVADSNNNRV 271
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
801-826 |
2.43e-09 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 54.44 E-value: 2.43e-09
10 20
....*....|....*....|....*.
gi 569009288 801 CGDNLDNDGDGLTDCVDPDCCQQSNC 826
Cdd:NF033662 7 CSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1313-1523 |
2.49e-09 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 60.76 E-value: 2.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1313 PRGITVDRHGFIYFVDGT--MIRRIDENAVITTVIGSNGLTSTQplscdsgmditqvrLEWPTDLAVNPmDNSLYVLD-- 1388
Cdd:cd14956 62 PRGLAVDKDGWLYVADYWgdRIQVFTLTGELQTIGGSSGSGPGQ--------------FNAPRGVAVDA-DGNLYVADfg 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1389 NNIVLQISENRR-VRIIAGRPIHcqvPGidHFLvskvaihstleSARAISVSHSGLLFIAETderKVNRIQQVTTNGEIS 1467
Cdd:cd14956 127 NQRIQKFDPDGSfLRQWGGTGIE---PG--SFN-----------YPRGVAVDPDGTLYVADT---YNDRIQVFDNDGAFL 187
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 569009288 1468 IIAGAPtdcdckidpncdcFSGDGgyakdaKMKAPSSLAVSPDGTLYVADLGNVRI 1523
Cdd:cd14956 188 RKWGGR-------------GTGPG------QFNYPYGIAIDPDGNVFVADFGNNRI 224
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1195-1524 |
6.55e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 59.65 E-value: 6.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1195 PVALASGPDGSVYVGDF--NFVRRIFPSGNSVsilelrnrdTRHSTSPAHKYY-LAMDPmSESLYLSDTNTRKVYKLksl 1271
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPATGEF---------TEYPLGGGSGPHgIAVDP-DGNLWFTDNGNNRIGRI--- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1272 veTKDlSKNFEVVAGTGDQCLPFdqshcgdggkaseaslnsprGITVDRHGFIYFVDGT--MIRRIDenavittviGSNG 1349
Cdd:COG4257 86 --DPK-TGEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLD---------PATG 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1350 LTSTQPLSCDSGMditqvrlewPTDLAVNPmDNSLYVLDNnivlqisENRRVRIIagrpihcqvpGIDHFLVSKVAIHST 1429
Cdd:COG4257 134 EVTEFPLPTGGAG---------PYGIAVDP-DGNLWVTDF-------GANAIGRI----------DPDTGTLTEYALPTP 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1430 LESARAISVSHSGLLFIAETDERKVNRIQqvTTNGEISIIAGAPTDcdckidpncdcfsgdggyakdakmKAPSSLAVSP 1509
Cdd:COG4257 187 GAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTVTEYPLPGGG------------------------ARPYGVAVDG 240
|
330
....*....|....*
gi 569009288 1510 DGTLYVADLGNVRIR 1524
Cdd:COG4257 241 DGRVWFAESGANRIV 255
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1195-1523 |
2.08e-08 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 57.60 E-value: 2.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1195 PVALASGPDGSVYVGDfnfvrrifpSGNSVsILELRNRDTRHSTSPAHKYY----LAMDPmSESLYLSDTNTRKVYKLks 1270
Cdd:cd14952 12 PGGVAVDAAGNVYVAD---------SGNNR-VLKLAAGSTTQTVLPFTGLYqpqgVAVDA-AGTVYVTDFGNNRVLKL-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1271 lvetkdlsknfevVAGTGDQC-LPFdqshcgdggkaseASLNSPRGITVDRHGFIYFVDGTmirridENAVITTVIGSNg 1349
Cdd:cd14952 79 -------------AAGSTTQTvLPF-------------TGLNDPTGVAVDAAGNVYVADTG------NNRVLKLAAGSN- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1350 ltstqplscdsgmdiTQVRLEW-----PTDLAVNPMDNsLYVLDnnivlqiSENRRVRiiagrpihcqvpgidhflvsKV 1424
Cdd:cd14952 126 ---------------TQTVLPFtglsnPDGVAVDGAGN-VYVTD-------TGNNRVL--------------------KL 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1425 AIHST---------LESARAISVSHSGLLFIAETDErkvNRIQQVTtngeisiiAGAPTdcdckidPNCDCFSGdggyak 1495
Cdd:cd14952 163 AAGSTtqtvlpftgLNSPSGVAVDTAGNVYVTDHGN---NRVLKLA--------AGSTT-------PTVLPFTG------ 218
|
330 340
....*....|....*....|....*...
gi 569009288 1496 dakMKAPSSLAVSPDGTLYVADLGNVRI 1523
Cdd:cd14952 219 ---LNGPLGVAVDAAGNVYVADRGNDRV 243
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1191-1404 |
3.67e-08 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 57.30 E-value: 3.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1191 KLFAPVALASGPDGSVYVGDFnFVRRI--F-PSGNSVSILElRNRDTRHSTSPAHkyyLAMDpmSESLYLSDTNTRKVY- 1266
Cdd:cd14963 54 EFKYPYGIAVDSDGNIYVADL-YNGRIqvFdPDGKFLKYFP-EKKDRVKLISPAG---LAID--DGKLYVSDVKKHKVIv 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1267 ------KLKSLVETKD-------------LSKNFEVVAGTGDQ-CLPFDQSHCG----DGGKASEASLNSPRGITVDRHG 1322
Cdd:cd14963 127 fdlegkLLLEFGKPGSepgelsypngiavDEDGNIYVADSGNGrIQVFDKNGKFikelNGSPDGKSGFVNPRGIAVDPDG 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1323 FIYFVDgTMIRRI---DENAVITTVIGSNGLtstqplscdsgmDITQVRLewPTDLAVNPmDNSLYVLDnnivlqiSENR 1399
Cdd:cd14963 207 NLYVVD-NLSHRVyvfDEQGKELFTFGGRGK------------DDGQFNL--PNGLFIDD-DGRLYVTD-------RENN 263
|
....*
gi 569009288 1400 RVRII 1404
Cdd:cd14963 264 RVAVY 268
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1307-1526 |
5.76e-07 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 53.48 E-value: 5.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1307 EASLNSPRGITVDRHGFIYFVDGT--MIRRID-ENAVITTVIGSNGLTStqplscdsgmditqvrlewPTDLAVNPmDNS 1383
Cdd:COG4257 55 LGGGSGPHGIAVDPDGNLWFTDNGnnRIGRIDpKTGEITTFALPGGGSN-------------------PHGIAFDP-DGN 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1384 LYVLDNNivlqiseNRRVRII---AGRpihcqvpgidhflVSKVAIHSTLESARAISVSHSGLLFIAEtdeRKVNRIQQV 1460
Cdd:COG4257 115 LWFTDQG-------GNRIGRLdpaTGE-------------VTEFPLPTGGAGPYGIAVDPDGNLWVTD---FGANAIGRI 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569009288 1461 TT-NGEISIIAGaPTdcdckidpncdcfsgdggyakdaKMKAPSSLAVSPDGTLYVADLGNVRIRTI 1526
Cdd:COG4257 172 DPdTGTLTEYAL-PT-----------------------PGAGPRGLAVDPDGNLWVADTGSGRIGRF 214
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
1310-1523 |
7.40e-07 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 53.32 E-value: 7.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1310 LNSPRGITVDRHGFIYFVD--GTMIRRIDENAVITTVIGSNGLTSTQplscdsgmditqvrLEWPTDLAVNPMDNsLYVL 1387
Cdd:cd14954 70 FDRPAGVAVNSRGRIIVADkdNHRIQVFDLNGRFLLKFGERGTKNGQ--------------FNYPWGVAVDSEGR-IYVS 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1388 DnnivlqiSENRRVRIIA--GRPIH---CQVPGIDHFlvskvaihstlESARAISVSHSGLLFIAETDErkvNRIQQVTT 1462
Cdd:cd14954 135 D-------TRNHRVQVFDsdGQFIRkfgFEGAGPGQL-----------DSPRGVAVNPDGNIVVSDFNN---HRLQVFDP 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1463 NGE-ISIIAGAPTDCDC-------KIDPN-----CDC-------FSGDGGYAK--------DAKMKAPSSLAVSPDGTLY 1514
Cdd:cd14954 194 DGQfLRFFGSEGSGNGQfkrprgvAVDDEgniivADSgnhrvqvFSPDGEFLCsfgtegngEGQFDRPSGVAVTPDGRIV 273
|
....*....
gi 569009288 1515 VADLGNVRI 1523
Cdd:cd14954 274 VVDRGNHRI 282
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1303-1526 |
1.84e-06 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 52.58 E-value: 1.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1303 GKASEASLNSPRGITVDRHGFIYFVDgT---MIRRID-ENAVITTVIGsnglTSTQPLSCDSGMDITQVRLEWPTDLAVN 1378
Cdd:cd14951 11 GSFAEASFNEPQGLALLPGNILYVAD-TenhALRKIDlETGTVTTLAG----TGEQGRDGEGGGPGREQPLSSPWDVAWG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1379 PMDNSLYV------------LDNNIVLQISENRRVRIIAGRPIH----CQVPGI----DHFL------------------ 1420
Cdd:cd14951 86 PEDDILYIamagthqiwaydLDTGTCRVFAGSGNEGNRNGPYPHeawfAQPSGLslagWGELfvadsessairavslkdg 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1421 VSKVAIHSTL---------------ESAR-----AISVSHSGLLFIAETDERKVNRIQQVTtnGEISIIAGaptdcdcki 1480
Cdd:cd14951 166 GVKTLVGGTRvgtglfdfgdrdgpgAEALlqhplGVAALPDGSVYVADTYNHKIKRVDPAT--GEVSTLAG--------- 234
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 569009288 1481 dpncdcfSGDGGYAKDAKMKA-PSSLAVSPDGTLYVADLGNVRIRTI 1526
Cdd:cd14951 235 -------TGKAGYKDLEAQFSePSGLVVDGDGRLYVADTNNHRIRRL 274
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
528-719 |
3.21e-06 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 51.16 E-value: 3.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 528 DDCSTNCNGNGECISGHCH-----------------CFPGFLGPdcaRDSCpvlCGG----NGE----------YEKGHC 576
Cdd:pfam19232 10 DDCTPPCGGTQVCIDRQCKdntlacttdaqcgtcmtCVAGACTP---KASC---CGGvtcgAGQtcdaktntcvYVKGYC 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 577 VC-RNGWKGPECDVPEEQCIDPTCFGHGT---CIMGV-----------------CICV------------PGYKGEICEE 623
Cdd:pfam19232 84 SAdHPCPSGSACDTAKNACIAQPPYGPDSgkgCVRGFgawiweldpatnsgvwrCRCAngslynsahecsPLADQTLCAA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 624 EDcLDPMC------------------------SSHGICVK----GECHCSTGWGGVNCETplpicQEQCSGHGTFLLDTG 675
Cdd:pfam19232 164 EN-LDPNAlvpassvpafaaygwgnqpvlinkSTAGAAVPsplaGVCPCKPGWAGGSCTE-----DRTCNGRGTWNETTG 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 569009288 676 VCSCDPKWTGSDcstelctmECGSHGVCSRgicqceegWVGPTC 719
Cdd:pfam19232 238 QCACNIDFSGHN--------SCGDDNNCTS--------WTGPRC 265
|
|
| NHL_like_6 |
cd14962 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1195-1523 |
5.60e-06 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 50.66 E-value: 5.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1195 PVALASGPDGSVYVGDfnfvrrifPSGNSVSILELRNRDT--------RHSTSPAHkyyLAMDPmSESLYLSDTNTRKVY 1266
Cdd:cd14962 14 PYGVAADGRGRIYVAD--------TGRGAVFVFDLPNGKVfvignagpNRFVSPIG---VAIDA-NGNLYVSDAELGKVF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1267 KLkslvetkDLSKNFEVVAGTGDQclpfdqshcgdggkaseasLNSPRGITVDRHG-FIYFVD--GTMIRRIDENAVITT 1343
Cdd:cd14962 82 VF-------DRDGKFLRAIGAGAL-------------------FKRPTGIAVDPAGkRLYVVDtlAHKVKVFDLDGRLLF 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1344 VIGSNGltstqplscdSGmditQVRLEWPTDLAVNPMDNsLYVLDnnivlqiSENRRVRII--AGRPIHC-----QVPGi 1416
Cdd:cd14962 136 DIGKRG----------SG----PGEFNLPTDLAVDRDGN-LYVTD-------TMNFRVQIFdaDGKFLRSfgergDGPG- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1417 dhflvskvaihsTLESARAISVSHSGLLFIAETderKVNRIQQVTTNGEISIIAGAPtdcdckidpncdcFSGDGGYAkd 1496
Cdd:cd14962 193 ------------SFARPKGIAVDSEGNIYVVDA---AFDNVQIFNPEGELLLTVGGP-------------GSGPGEFY-- 242
|
330 340
....*....|....*....|....*..
gi 569009288 1497 akmkAPSSLAVSPDGTLYVADLGNVRI 1523
Cdd:cd14962 243 ----LPSGIAIDKDDRIYVVDQFNRRI 265
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2344-2422 |
1.66e-05 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 45.18 E-value: 1.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 2344 YTPYGDIYHDTyPDFEVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNhhiwkqlnllpkPF------NLYSFENNY 2417
Cdd:TIGR03696 1 YDPYGEVLSES-GAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD------------PIglggglNLYAYVGNN 67
|
....*
gi 569009288 2418 PVGKI 2422
Cdd:TIGR03696 68 PVNWV 72
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
1850-1890 |
1.93e-05 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 43.73 E-value: 1.93e-05
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 569009288 1850 YSPSG-LVTFIQRGTWNEKMEYDQSGKIISRTWADGKIWSYT 1890
Cdd:TIGR01643 1 YDAAGrLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRYE 42
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1487-1529 |
3.12e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 48.68 E-value: 3.12e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 569009288 1487 FSGDGGyaKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISKN 1529
Cdd:cd14953 12 FSGGGG--TAARFNSPSGVAVDAAGNLYVADRGNHRIRKITPD 52
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1573-1688 |
3.44e-05 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 49.62 E-value: 3.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1573 FTYNAEGDLGAITSSNGNSVHIRRDAGGMPLwlvvpggqvywltISSNGVLKRvsAQGYNLAlmtypgntGLLATKSNEN 1652
Cdd:NF041261 602 YEYNAAGDLTAVITPDGNRSETQYDAWGKAV-------------STTQGGLTR--SMEYDAA--------GRITTLTNEN 658
|
90 100 110
....*....|....*....|....*....|....*..
gi 569009288 1653 GWTTVYEYDPEGHLTNATFPTGEVSSFHSDLE-KLTK 1688
Cdd:NF041261 659 GSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTgKLTQ 695
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1194-1470 |
4.46e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 47.71 E-value: 4.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1194 APVALASGPDGSVYVGDFNF--VRRIFPSGNSVSILELrnrdtrhSTSPAHKYYLAMDPmSESLYLSDTNTRKVYKLksl 1271
Cdd:COG4257 60 GPHGIAVDPDGNLWFTDNGNnrIGRIDPKTGEITTFAL-------PGGGSNPHGIAFDP-DGNLWFTDQGGNRIGRL--- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1272 vetkDLSKN-FEVVAGTGDQclpfdqshcgdggkaseaslNSPRGITVDRHGFIYFVD--GTMIRRID-ENAVITTVIGS 1347
Cdd:COG4257 129 ----DPATGeVTEFPLPTGG--------------------AGPYGIAVDPDGNLWVTDfgANAIGRIDpDTGTLTEYALP 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1348 NGLTStqplscdsgmditqvrlewPTDLAVNPmDNSLYVLDnnivlqiSENRRVRII---AGRpihcqvpgidhflVSKV 1424
Cdd:COG4257 185 TPGAG-------------------PRGLAVDP-DGNLWVAD-------TGSGRIGRFdpkTGT-------------VTEY 224
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 569009288 1425 AIHSTLESARAISVSHSGLLFIAETDerkVNRIQQVTTNGEISIIA 1470
Cdd:COG4257 225 PLPGGGARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTELTEYV 267
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1372-1534 |
2.07e-04 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 45.74 E-value: 2.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1372 PTDLAVNPMDNSLYVLDNNIVLQI--SENRRVRIIAGRPihcqvPGIDHFlvskvaihstlESARAISVSHSGLLFIAET 1449
Cdd:cd14956 15 PRGIAVDADDNVYVADARNGRIQVfdKDGTFLRRFGTTG-----DGPGQF-----------GRPRGLAVDKDGWLYVADY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1450 DErkvNRIQQVTTNGEISIIAGAPTdcdckidpncdcfSGDGGYAkdakmkAPSSLAVSPDGTLYVADLGNVRIRTISKN 1529
Cdd:cd14956 79 WG---DRIQVFTLTGELQTIGGSSG-------------SGPGQFN------APRGVAVDADGNLYVADFGNQRIQKFDPD 136
|
....*
gi 569009288 1530 QAHLN 1534
Cdd:cd14956 137 GSFLR 141
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
710-753 |
2.33e-04 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 40.68 E-value: 2.33e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 569009288 710 CEEGWVGPTCEeRSC--------HSHCAEHGQCkdgkcECSPGWEGDHCTIA 753
Cdd:pfam01414 1 CDENYYGSTCS-KFCrprddkfgHYTCDANGNK-----VCLPGWTGPYCDKP 46
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
1198-1345 |
1.68e-03 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 42.96 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1198 LASGPDGSVYVGDFNFVR------RIFPSGnSVSILElrnRDTRHSTSpahkyyLAMDPMSESLYLSDTNTRKVYKLkSL 1271
Cdd:COG3386 98 GVVDPDGRLYFTDMGEYLptgalyRVDPDG-SLRVLA---DGLTFPNG------IAFSPDGRTLYVADTGAGRIYRF-DL 166
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569009288 1272 VETKDLSkNFEVVAgtgdqclpfdQSHCGDGGkaseaslnsPRGITVDRHGFIY--FVDGTMIRRIDENAVITTVI 1345
Cdd:COG3386 167 DADGTLG-NRRVFA----------DLPDGPGG---------PDGLAVDADGNLWvaLWGGGGVVRFDPDGELLGRI 222
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
664-688 |
1.82e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 1.82e-03
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
696-719 |
2.01e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 2.01e-03
10 20
....*....|....*....|....*.
gi 569009288 696 ECGSHGVCSR--GICQCEEGWVGPTC 719
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1495-1529 |
2.71e-03 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 42.31 E-value: 2.71e-03
10 20 30
....*....|....*....|....*....|....*
gi 569009288 1495 KDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISKN 1529
Cdd:cd05819 3 GPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPD 37
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
650-793 |
2.97e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.51 E-value: 2.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 650 GVNCETPLPICQEQCsghgtflLDTgvcSCDPkwtgSDCSTelCTMECGSHGVCSRGICQCEEGWV--GPTC-EERS--- 723
Cdd:NF041328 18 GAVCPEGLSVCGGAC-------VDL---RSDP----SNCGA--CGVACGAGQTCVAGACGCGPGTVacGGACvDTASdpa 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569009288 724 ----CHSHCAEHGQCKDGKCecspgwegdhctiahyldavRDGCP-GLCFGNGRCT-LDQNGWHCvcqvGWSGTGC 793
Cdd:NF041328 82 hcgaCGAACAPGQVCEGGAC--------------------REACSeGLTRCGGACVdLATDPLHC----GACGVAC 133
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
534-556 |
3.70e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.94 E-value: 3.70e-03
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
728-750 |
4.73e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.56 E-value: 4.73e-03
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1190-1268 |
5.05e-03 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 41.54 E-value: 5.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 1190 NKLFAPVALASGPDGSVYVGDF--NFVRRIFPSGNSVSILELrnrdtrhSTSPAHKYYLAMDPMSeSLYLSDTNTRKVYK 1267
Cdd:COG4257 185 TPGAGPRGLAVDPDGNLWVADTgsGRIGRFDPKTGTVTEYPL-------PGGGARPYGVAVDGDG-RVWFAESGANRIVR 256
|
.
gi 569009288 1268 L 1268
Cdd:COG4257 257 F 257
|
|
| Keratin_B2 |
pfam01500 |
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ... |
594-730 |
7.68e-03 |
|
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.
Pssm-ID: 366678 [Multi-domain] Cd Length: 161 Bit Score: 39.77 E-value: 7.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569009288 594 CIDPTCFGHGTCIMGVCicvpgykGEICEEEDCLDPMCSSHGIC--VKGECHCSTGWGGVNCETPL--PIC------QEQ 663
Cdd:pfam01500 9 CGFPTCSTGGTCGSGCC-------QPCCCQSSCCRPSCCQTSCCqpTTFQSSCCRPTCQPCCQTSCcqPTCcqtsscQTG 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569009288 664 CSGHGTFLL-DTGVCSCDPKWTGSDCSTE-LCTMECGSHGVCSRGICQ--------CEEGWVGPTCEERSCHSHCAE 730
Cdd:pfam01500 82 CGGIGYGQEgSSGAVSSRTRWCRPDCRVEgTCLPPCCVVSCTPPTCCQlhhaqascCRPSYCGQSCCRPACCCQCSE 158
|
|
| |
