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Conserved domains on  [gi|612003449|ref|XP_007486455|]
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centromere protein K isoform X1 [Monodelphis domestica]

Protein Classification

CENP-K domain-containing protein( domain architecture ID 12111562)

CENP-K domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CENP-K pfam11802
Centromere-associated protein K; CENP-K is one of seven new CENP-A-nucleosome distal (CAD) ...
12-270 1.71e-135

Centromere-associated protein K; CENP-K is one of seven new CENP-A-nucleosome distal (CAD) centromere components (the others being CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) that are identified as assembling on the CENP-A nucleosome associated complex, NAC. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling. CENP-K is centromere-associated through its interaction with one or more components of the CENP-A NAC.


:

Pssm-ID: 463355 [Multi-domain]  Cd Length: 263  Bit Score: 382.88  E-value: 1.71e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612003449   12 DIENKEYIVDRKDKLIEECEELWKQMEKCQQEIALAGGERLNHSDAQLTLLMMRVKSLTAECNQWLERTPDIIPLNPESL 91
Cdd:pfam11802   1 ETTDVEEVTDAKEELLDECEELWKDMEECQNKLSLIGTETLTDSDAQLSLLIMQVKALTAELEQWQKRTPEIISLNPEVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612003449   92 VVLGKDELQKLDHNLEILLSTIQSKNQKLKEDLTREQEWLNEQEHLVTSLSKKCKERKNQVIPFSEQRTFFEMNTKMTKI 171
Cdd:pfam11802  81 LTLGKEELQKLRHQLEMVLSTIQSKNKKLKEDLEREQQWLDEQQQILESLNEKHKELKNQVVTFSEKRKFQELKTKIRKI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612003449  172 QSQREKLLNSLGEFLDKHFPPPEENGN----KRKRECKPTAQLKTLREILEVLINSLLRSPYNPYVKIDDSYWPPYIELL 247
Cdd:pfam11802 161 KEYKEKLLTTLGEFLDEHFPLPEENGNsvkkKRKNSQEPTINLITLHEILEILINKLLDTPHDPYVKIDDSFWPPYIELL 240
                         250       260
                  ....*....|....*....|...
gi 612003449  248 LRNGIALRHQDDPNQIRLEAFHQ 270
Cdd:pfam11802 241 LRNGIALRHPEDPNRIRLEAFHQ 263
 
Name Accession Description Interval E-value
CENP-K pfam11802
Centromere-associated protein K; CENP-K is one of seven new CENP-A-nucleosome distal (CAD) ...
12-270 1.71e-135

Centromere-associated protein K; CENP-K is one of seven new CENP-A-nucleosome distal (CAD) centromere components (the others being CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) that are identified as assembling on the CENP-A nucleosome associated complex, NAC. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling. CENP-K is centromere-associated through its interaction with one or more components of the CENP-A NAC.


Pssm-ID: 463355 [Multi-domain]  Cd Length: 263  Bit Score: 382.88  E-value: 1.71e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612003449   12 DIENKEYIVDRKDKLIEECEELWKQMEKCQQEIALAGGERLNHSDAQLTLLMMRVKSLTAECNQWLERTPDIIPLNPESL 91
Cdd:pfam11802   1 ETTDVEEVTDAKEELLDECEELWKDMEECQNKLSLIGTETLTDSDAQLSLLIMQVKALTAELEQWQKRTPEIISLNPEVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612003449   92 VVLGKDELQKLDHNLEILLSTIQSKNQKLKEDLTREQEWLNEQEHLVTSLSKKCKERKNQVIPFSEQRTFFEMNTKMTKI 171
Cdd:pfam11802  81 LTLGKEELQKLRHQLEMVLSTIQSKNKKLKEDLEREQQWLDEQQQILESLNEKHKELKNQVVTFSEKRKFQELKTKIRKI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612003449  172 QSQREKLLNSLGEFLDKHFPPPEENGN----KRKRECKPTAQLKTLREILEVLINSLLRSPYNPYVKIDDSYWPPYIELL 247
Cdd:pfam11802 161 KEYKEKLLTTLGEFLDEHFPLPEENGNsvkkKRKNSQEPTINLITLHEILEILINKLLDTPHDPYVKIDDSFWPPYIELL 240
                         250       260
                  ....*....|....*....|...
gi 612003449  248 LRNGIALRHQDDPNQIRLEAFHQ 270
Cdd:pfam11802 241 LRNGIALRHPEDPNRIRLEAFHQ 263
 
Name Accession Description Interval E-value
CENP-K pfam11802
Centromere-associated protein K; CENP-K is one of seven new CENP-A-nucleosome distal (CAD) ...
12-270 1.71e-135

Centromere-associated protein K; CENP-K is one of seven new CENP-A-nucleosome distal (CAD) centromere components (the others being CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) that are identified as assembling on the CENP-A nucleosome associated complex, NAC. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling. CENP-K is centromere-associated through its interaction with one or more components of the CENP-A NAC.


Pssm-ID: 463355 [Multi-domain]  Cd Length: 263  Bit Score: 382.88  E-value: 1.71e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612003449   12 DIENKEYIVDRKDKLIEECEELWKQMEKCQQEIALAGGERLNHSDAQLTLLMMRVKSLTAECNQWLERTPDIIPLNPESL 91
Cdd:pfam11802   1 ETTDVEEVTDAKEELLDECEELWKDMEECQNKLSLIGTETLTDSDAQLSLLIMQVKALTAELEQWQKRTPEIISLNPEVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612003449   92 VVLGKDELQKLDHNLEILLSTIQSKNQKLKEDLTREQEWLNEQEHLVTSLSKKCKERKNQVIPFSEQRTFFEMNTKMTKI 171
Cdd:pfam11802  81 LTLGKEELQKLRHQLEMVLSTIQSKNKKLKEDLEREQQWLDEQQQILESLNEKHKELKNQVVTFSEKRKFQELKTKIRKI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612003449  172 QSQREKLLNSLGEFLDKHFPPPEENGN----KRKRECKPTAQLKTLREILEVLINSLLRSPYNPYVKIDDSYWPPYIELL 247
Cdd:pfam11802 161 KEYKEKLLTTLGEFLDEHFPLPEENGNsvkkKRKNSQEPTINLITLHEILEILINKLLDTPHDPYVKIDDSFWPPYIELL 240
                         250       260
                  ....*....|....*....|...
gi 612003449  248 LRNGIALRHQDDPNQIRLEAFHQ 270
Cdd:pfam11802 241 LRNGIALRHPEDPNRIRLEAFHQ 263
ORC3_ins pfam19675
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ...
91-194 5.86e-04

Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ORC subunit 3 (ORC3) located between the N-terminal AAA+-like subunit and the C-terminal winged- helix (WH) DNA-binding domain. ORC3 is a component of the origin recognition complex (ORC) that binds origins of replication, required to assemble the pre-replication complex necessary to initiate DNA replication. This domain insertion forms a bi-lobed alpha-helical protuberance that engages a short alpha-helix formed at the ORC6 C-terminal, allowing its binding to ORC1-5 subunits, which constitute the ORC core.


Pssm-ID: 466140  Cd Length: 233  Bit Score: 40.15  E-value: 5.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612003449   91 LVVLGKDELQKLDHN-LEILLSTIQ----SKNQKLKEDLTREQ--EWLNEQEHLVTSLSKKCKERKNQVipFSEQRTFFE 163
Cdd:pfam19675 106 LRMLAKDELVTLLQKcVEILKSSKGkdlgSTAKKLEEFLAQFQklDGCENNEEEVTSGSQKKLQQKTDL--YHLQKTLLE 183
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 612003449  164 M-----NTKMTKIQSQREKLLNSLGEFLDKHFPPPE 194
Cdd:pfam19675 184 MkesrrSKKLTKFEVLREKVVDFIDSLVRKYLLPPE 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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