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Conserved domains on  [gi|620975311|ref|XP_007668267|]
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kit ligand isoform X1 [Ornithorhynchus anatinus]

Protein Classification

SCF domain-containing protein( domain architecture ID 10493332)

SCF domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SCF pfam02404
Stem cell factor; Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds ...
1-273 0e+00

Stem cell factor; Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. The crystal structure of human SCF has been resolved and a potential receptor-binding site identified.


:

Pssm-ID: 396808  Cd Length: 275  Bit Score: 537.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620975311    1 MKKTQTWIITCIYLQLLLFIPLIRAQKNCGNPVTDDVKDITKLVGNLPNDYMIALKYVPEMDGLPNHCWLHLMVPELAKS 80
Cdd:pfam02404   1 MKKTQTWIITCIYLQLLLFNPLVKTQSICGNPVTDDVKDITKLVGNLPNDYMIALKYVPKMDVLPNHCWLHLMVPELSKS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620975311   81 LNNLLQKFSEISESLSNYSIINNLTRIIDDLMACLASDKNKHFVQRNIHLYKKGSFIPKEFFGYFNRSIEAFRDF--QAE 158
Cdd:pfam02404  81 LTNLLDKFSEISEMLSNYSIINNLTRIIDDLMACLEEDKNKNFVKENIHLYEEGRFIPEEFFRIFNRSIEAFKDFavTSD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620975311  159 HSDCIFPTTTLMPEKDSRVSVTKPFLLPPVAASSLKNDSTSSNREAFGYISSSSLQWISIAVPSIFSLVIGFILGAIYWK 238
Cdd:pfam02404 161 TSDCVLPSTTLTPENDSRVSVTKPFLLPPVAASSLRNDSSSSNRKALGSIGSPSLQWISIALPSLFSLVIGFILGALYWK 240
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 620975311  239 KKHPKHSVEVENIQGNEEDNEISMLQERERELQEV 273
Cdd:pfam02404 241 KKQPKLTREVENIQINEEDNEISMLQQKEREFQEV 275
 
Name Accession Description Interval E-value
SCF pfam02404
Stem cell factor; Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds ...
1-273 0e+00

Stem cell factor; Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. The crystal structure of human SCF has been resolved and a potential receptor-binding site identified.


Pssm-ID: 396808  Cd Length: 275  Bit Score: 537.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620975311    1 MKKTQTWIITCIYLQLLLFIPLIRAQKNCGNPVTDDVKDITKLVGNLPNDYMIALKYVPEMDGLPNHCWLHLMVPELAKS 80
Cdd:pfam02404   1 MKKTQTWIITCIYLQLLLFNPLVKTQSICGNPVTDDVKDITKLVGNLPNDYMIALKYVPKMDVLPNHCWLHLMVPELSKS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620975311   81 LNNLLQKFSEISESLSNYSIINNLTRIIDDLMACLASDKNKHFVQRNIHLYKKGSFIPKEFFGYFNRSIEAFRDF--QAE 158
Cdd:pfam02404  81 LTNLLDKFSEISEMLSNYSIINNLTRIIDDLMACLEEDKNKNFVKENIHLYEEGRFIPEEFFRIFNRSIEAFKDFavTSD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620975311  159 HSDCIFPTTTLMPEKDSRVSVTKPFLLPPVAASSLKNDSTSSNREAFGYISSSSLQWISIAVPSIFSLVIGFILGAIYWK 238
Cdd:pfam02404 161 TSDCVLPSTTLTPENDSRVSVTKPFLLPPVAASSLRNDSSSSNRKALGSIGSPSLQWISIALPSLFSLVIGFILGALYWK 240
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 620975311  239 KKHPKHSVEVENIQGNEEDNEISMLQERERELQEV 273
Cdd:pfam02404 241 KKQPKLTREVENIQINEEDNEISMLQQKEREFQEV 275
 
Name Accession Description Interval E-value
SCF pfam02404
Stem cell factor; Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds ...
1-273 0e+00

Stem cell factor; Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. The crystal structure of human SCF has been resolved and a potential receptor-binding site identified.


Pssm-ID: 396808  Cd Length: 275  Bit Score: 537.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620975311    1 MKKTQTWIITCIYLQLLLFIPLIRAQKNCGNPVTDDVKDITKLVGNLPNDYMIALKYVPEMDGLPNHCWLHLMVPELAKS 80
Cdd:pfam02404   1 MKKTQTWIITCIYLQLLLFNPLVKTQSICGNPVTDDVKDITKLVGNLPNDYMIALKYVPKMDVLPNHCWLHLMVPELSKS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620975311   81 LNNLLQKFSEISESLSNYSIINNLTRIIDDLMACLASDKNKHFVQRNIHLYKKGSFIPKEFFGYFNRSIEAFRDF--QAE 158
Cdd:pfam02404  81 LTNLLDKFSEISEMLSNYSIINNLTRIIDDLMACLEEDKNKNFVKENIHLYEEGRFIPEEFFRIFNRSIEAFKDFavTSD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620975311  159 HSDCIFPTTTLMPEKDSRVSVTKPFLLPPVAASSLKNDSTSSNREAFGYISSSSLQWISIAVPSIFSLVIGFILGAIYWK 238
Cdd:pfam02404 161 TSDCVLPSTTLTPENDSRVSVTKPFLLPPVAASSLRNDSSSSNRKALGSIGSPSLQWISIALPSLFSLVIGFILGALYWK 240
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 620975311  239 KKHPKHSVEVENIQGNEEDNEISMLQERERELQEV 273
Cdd:pfam02404 241 KKQPKLTREVENIQINEEDNEISMLQQKEREFQEV 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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