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Conserved domains on  [gi|637322031|ref|XP_008112965|]
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nuclear receptor-binding factor 2 isoform X2 [Anolis carolinensis]

Protein Classification

NRBF2_MIT and NRBF2 domain-containing protein( domain architecture ID 12182481)

NRBF2_MIT and NRBF2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NRBF2 pfam08961
Nuclear receptor-binding factor 2, autophagy regulator; NRBF2 plays an essential role in ...
 95-295 1.88e-114

Nuclear receptor-binding factor 2, autophagy regulator; NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction.


:

Pssm-ID: 430345  Cd Length: 200  Bit Score: 328.42  E-value: 1.88e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322031   95 AMDRDGVTHPQASSKPSAEESDDQSVAAPASLKYSPSPEKDLQAKLSVLDRDPDTLLFLLQKRKEPQEACVRSKTPKDDK 174
Cdd:pfam08961   1 VTDRDAAAHLQASPKPSAEEADGQSVLGPASQKYSPSPEKYLQEIQSVFDRDPDTLLFLLQKRKEPTETCIGSKAPKDDK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322031  175 TKMEEQATKIALLERHVEVLLAENERLRQENKQLKAERARLLKSPLEKELDVDADFVEKSELWGLQQHSETaAATSASSW 254
Cdd:pfam08961  81 TKIEEQATKIAELKRHVEFLLAENERLRKENKQLKAEKARLQKNPIEKELDVDADFVEKSELWGLQQHSES-AATAASTW 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 637322031  255 QKFTSSAGKAKDIPIPSLPPLDIPSPELPLLELSEDILKGL 295
Cdd:pfam08961 160 QKFTANAGKAKDIPIPNLPPLDIPSPELPLLELSEDILKGL 200
NRBF2_MIT pfam17169
MIT domain of nuclear receptor-binding factor 2; This MIT domain is the microtubule ...
 10-91 3.38e-41

MIT domain of nuclear receptor-binding factor 2; This MIT domain is the microtubule interaction and trafficking of nuclear receptor-binding factor 2 - NRBF2 - in higher eukaryotes. It is a coiled-coil region at the N-terminus of pfam08961. NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction.


:

Pssm-ID: 465368  Cd Length: 83  Bit Score: 137.53  E-value: 3.38e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322031   10 MEGPLNLAHQQSRKADRSLAVGKYEEAISCHKKAAAYLSDAMKLTQSDQAQLSLQLQKESHLKQILLIQERWKRAKREER 89
Cdd:pfam17169   1 MEGPLNLAHQQSRRADRLLAAGKYEEAISCHKKAAAYLSEAMKLTKSEQAHLSLELQRDSHMKQLLLIQERWKRAKREER 80


                  ..
gi 637322031   90 LK 91
Cdd:pfam17169  81 LK 82
 
Name Accession Description Interval E-value
NRBF2 pfam08961
Nuclear receptor-binding factor 2, autophagy regulator; NRBF2 plays an essential role in ...
 95-295 1.88e-114

Nuclear receptor-binding factor 2, autophagy regulator; NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction.


Pssm-ID: 430345  Cd Length: 200  Bit Score: 328.42  E-value: 1.88e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322031   95 AMDRDGVTHPQASSKPSAEESDDQSVAAPASLKYSPSPEKDLQAKLSVLDRDPDTLLFLLQKRKEPQEACVRSKTPKDDK 174
Cdd:pfam08961   1 VTDRDAAAHLQASPKPSAEEADGQSVLGPASQKYSPSPEKYLQEIQSVFDRDPDTLLFLLQKRKEPTETCIGSKAPKDDK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322031  175 TKMEEQATKIALLERHVEVLLAENERLRQENKQLKAERARLLKSPLEKELDVDADFVEKSELWGLQQHSETaAATSASSW 254
Cdd:pfam08961  81 TKIEEQATKIAELKRHVEFLLAENERLRKENKQLKAEKARLQKNPIEKELDVDADFVEKSELWGLQQHSES-AATAASTW 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 637322031  255 QKFTSSAGKAKDIPIPSLPPLDIPSPELPLLELSEDILKGL 295
Cdd:pfam08961 160 QKFTANAGKAKDIPIPNLPPLDIPSPELPLLELSEDILKGL 200
NRBF2_MIT pfam17169
MIT domain of nuclear receptor-binding factor 2; This MIT domain is the microtubule ...
 10-91 3.38e-41

MIT domain of nuclear receptor-binding factor 2; This MIT domain is the microtubule interaction and trafficking of nuclear receptor-binding factor 2 - NRBF2 - in higher eukaryotes. It is a coiled-coil region at the N-terminus of pfam08961. NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction.


Pssm-ID: 465368  Cd Length: 83  Bit Score: 137.53  E-value: 3.38e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322031   10 MEGPLNLAHQQSRKADRSLAVGKYEEAISCHKKAAAYLSDAMKLTQSDQAQLSLQLQKESHLKQILLIQERWKRAKREER 89
Cdd:pfam17169   1 MEGPLNLAHQQSRRADRLLAAGKYEEAISCHKKAAAYLSEAMKLTKSEQAHLSLELQRDSHMKQLLLIQERWKRAKREER 80


                  ..
gi 637322031   90 LK 91
Cdd:pfam17169  81 LK 82
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 166-220 9.39e-04

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 40.20  E-value: 9.39e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 637322031 166 RSKTPKDDKTKMEEQatkIALLERHVEVLLAENERLRQENKQLKAERARLLKSPL 220
Cdd:PRK03992   2 RLEALEERNSELEEQ---IRQLELKLRDLEAENEKLERELERLKSELEKLKSPPL 53
FtsB COG2919
Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];
187-215 4.83e-03

Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442163 [Multi-domain]  Cd Length: 96  Bit Score: 35.63  E-value: 4.83e-03
                         10        20
                 ....*....|....*....|....*....
gi 637322031 187 LERHVEVLLAENERLRQENKQLKAERARL 215
Cdd:COG2919   34 LRQEIAELEAENAKLKARNAELEAEVADL 62
 
Name Accession Description Interval E-value
NRBF2 pfam08961
Nuclear receptor-binding factor 2, autophagy regulator; NRBF2 plays an essential role in ...
 95-295 1.88e-114

Nuclear receptor-binding factor 2, autophagy regulator; NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction.


Pssm-ID: 430345  Cd Length: 200  Bit Score: 328.42  E-value: 1.88e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322031   95 AMDRDGVTHPQASSKPSAEESDDQSVAAPASLKYSPSPEKDLQAKLSVLDRDPDTLLFLLQKRKEPQEACVRSKTPKDDK 174
Cdd:pfam08961   1 VTDRDAAAHLQASPKPSAEEADGQSVLGPASQKYSPSPEKYLQEIQSVFDRDPDTLLFLLQKRKEPTETCIGSKAPKDDK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322031  175 TKMEEQATKIALLERHVEVLLAENERLRQENKQLKAERARLLKSPLEKELDVDADFVEKSELWGLQQHSETaAATSASSW 254
Cdd:pfam08961  81 TKIEEQATKIAELKRHVEFLLAENERLRKENKQLKAEKARLQKNPIEKELDVDADFVEKSELWGLQQHSES-AATAASTW 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 637322031  255 QKFTSSAGKAKDIPIPSLPPLDIPSPELPLLELSEDILKGL 295
Cdd:pfam08961 160 QKFTANAGKAKDIPIPNLPPLDIPSPELPLLELSEDILKGL 200
NRBF2_MIT pfam17169
MIT domain of nuclear receptor-binding factor 2; This MIT domain is the microtubule ...
 10-91 3.38e-41

MIT domain of nuclear receptor-binding factor 2; This MIT domain is the microtubule interaction and trafficking of nuclear receptor-binding factor 2 - NRBF2 - in higher eukaryotes. It is a coiled-coil region at the N-terminus of pfam08961. NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction.


Pssm-ID: 465368  Cd Length: 83  Bit Score: 137.53  E-value: 3.38e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322031   10 MEGPLNLAHQQSRKADRSLAVGKYEEAISCHKKAAAYLSDAMKLTQSDQAQLSLQLQKESHLKQILLIQERWKRAKREER 89
Cdd:pfam17169   1 MEGPLNLAHQQSRRADRLLAAGKYEEAISCHKKAAAYLSEAMKLTKSEQAHLSLELQRDSHMKQLLLIQERWKRAKREER 80


                  ..
gi 637322031   90 LK 91
Cdd:pfam17169  81 LK 82
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 166-220 9.39e-04

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 40.20  E-value: 9.39e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 637322031 166 RSKTPKDDKTKMEEQatkIALLERHVEVLLAENERLRQENKQLKAERARLLKSPL 220
Cdd:PRK03992   2 RLEALEERNSELEEQ---IRQLELKLRDLEAENEKLERELERLKSELEKLKSPPL 53
FtsB COG2919
Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];
187-215 4.83e-03

Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442163 [Multi-domain]  Cd Length: 96  Bit Score: 35.63  E-value: 4.83e-03
                         10        20
                 ....*....|....*....|....*....
gi 637322031 187 LERHVEVLLAENERLRQENKQLKAERARL 215
Cdd:COG2919   34 LRQEIAELEAENAKLKARNAELEAEVADL 62
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 7-233 6.95e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 37.90  E-value: 6.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322031     7 MEVMEGPLNLAHQQSRKADRSLAVGKYEEAISCHKKAAAYLSDAMKltQSDQAQLSLQLQKEShLKQILLIQERWKRAKR 86
Cdd:pfam12128  587 LKRIDVPEWAASEEELRERLDKAEEALQSAREKQAAAEEQLVQANG--ELEKASREETFARTA-LKNARLDLRRLFDEKQ 663

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322031    87 EERLKIQQAMdrdgvthpqASSKPSAEESddqsvaapaslkyspspEKDLQAKLSVLDRDPDtlLFLLQKRKEPQEAcvr 166
Cdd:pfam12128  664 SEKDKKNKAL---------AERKDSANER-----------------LNSLEAQLKQLDKKHQ--AWLEEQKEQKREA--- 712

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 637322031   167 sKTPKDDKTKMEEQATKIALlERHVEVLLAENERLRQENKQLKAERARLLKSplekeLDVDADFVEK 233
Cdd:pfam12128  713 -RTEKQAYWQVVEGALDAQL-ALLKAAIAARRSGAKAELKALETWYKRDLAS-----LGVDPDVIAK 772
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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