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Conserved domains on  [gi|641649634|ref|XP_008186493|]
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nidogen-2 [Acyrthosiphon pisum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G2F pfam07474
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ...
 313-495 4.79e-64

G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.


:

Pssm-ID: 462175  Cd Length: 184  Bit Score: 215.15  E-value: 4.79e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634   313 VPVRVSGKVSIDVNGISMPESDLQAYVATMDGRVYMAISDVPSNLGFELQYLTVFPSVVAWLFSLHSENAFNGYQLTGGV 392
Cdd:pfam07474    2 VPQRVNGKVSGTINGVEFGDADLHAYVVTNDGRAYTAISNIPPSLGPLLQLLSSIGGPIGWLFALEQGGAKNGFSLTGGV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634   393 VNYTSEVTFPGTEHRITIHQRFFGLNSFDQLIMDATVQGTTPQVPlPHTRFTLPNDNHQQYTIANGRMHSYYTYRYKQEG 472
Cdd:pfam07474   82 FNRTAEVTFPPTGERLTITQEFRGLDEDGHLVVDTVISGTVPQVP-AGSTVIIEDYTELYQYTGPGELTSSSTRTYTVDG 160

                          170       180
                   ....*....|....*....|....*
gi 641649634   473 SDFEQQV--TVAQKFEFsQPCNKAA 495
Cdd:pfam07474  161 EGNTRTIsyTVNQTITY-QECRHAE 184
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
97-247 3.94e-34

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


:

Pssm-ID: 214712  Cd Length: 152  Bit Score: 128.31  E-value: 3.94e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634     97 FYANVDLRGSGQVYYREDRDPRTLAHANGLVSRFYpRYQGRFTATSVFVATWHRVGYYKKNADR-TNTFQVAVTTDGHET 175
Cdd:smart00539    2 FWADADTEGTGKVYYRETTDHAILDRATESVREGF-TDMGGFRAKSVVIVTWENVAAYGSQSSDgTNTFQAVLATDGSRT 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 641649634    176 FVQFAYPS-PIQWVQSFGGladEVGLPdakAQAGFSAADGRIHV-LRGSGSDQIHNLDRWSNTDAPGVWLYRVG 247
Cdd:smart00539   81 YAIFLYPSlGWTSDTTAGG---DDGVR---ARAGFNGGDGTFSYtLPASGEENIKNLAEGSNVGIPGRWMFRVD 148
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1140-1183 2.80e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.76  E-value: 2.80e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 641649634   1140 IIANSSLSNPRGIAVHPNRRKLFWSDWNRnsPKIEWSNLDGSQR 1183
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 582-617 2.30e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 51.06  E-value: 2.30e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 641649634   582 CQDRIDRCDPNAMCVNEVGTYSCQCRPGFEGNGYYC 617
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1115-1156 1.19e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 1.19e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 641649634  1115 RKIYWTDSGFK-RIMAADLsNGTHVTIIANSSLSNPRGIAVHP 1156
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADL-NGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
671-709 3.33e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 3.33e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 641649634    671 DVNECNIPEVCHRDSHCTNYPGTYACACNAGFIgDGLRC 709
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT-DGRNC 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1191-1223 1.00e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.74  E-value: 1.00e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 641649634   1191 NVKLPNSIAIDWYTDEMCWADAGLKSIECIGIE 1223
Cdd:smart00135    7 GLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 817-851 3.12e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.20  E-value: 3.12e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 641649634   817 CSKSN-ICDMHASCQIIEGHSICVCNSGYEGDGVIC 851
Cdd:pfam12947    1 CSDNNgGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 981-1017 3.95e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.82  E-value: 3.95e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 641649634   981 CVVNTSICHSLAQCmVDTSGHYICQCRQGYIGNGYYC 1017
Cdd:pfam12947    1 CSDNNGGCHPNATC-TNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 774-810 5.46e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.43  E-value: 5.46e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 641649634   774 CAEINT-CHAHAQCNFVSSQqrHKCQCNPGYEGDGYEC 810
Cdd:pfam12947    1 CSDNNGgCHPNATCTNTGGS--FTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
G2F pfam07474
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ...
 313-495 4.79e-64

G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.


Pssm-ID: 462175  Cd Length: 184  Bit Score: 215.15  E-value: 4.79e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634   313 VPVRVSGKVSIDVNGISMPESDLQAYVATMDGRVYMAISDVPSNLGFELQYLTVFPSVVAWLFSLHSENAFNGYQLTGGV 392
Cdd:pfam07474    2 VPQRVNGKVSGTINGVEFGDADLHAYVVTNDGRAYTAISNIPPSLGPLLQLLSSIGGPIGWLFALEQGGAKNGFSLTGGV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634   393 VNYTSEVTFPGTEHRITIHQRFFGLNSFDQLIMDATVQGTTPQVPlPHTRFTLPNDNHQQYTIANGRMHSYYTYRYKQEG 472
Cdd:pfam07474   82 FNRTAEVTFPPTGERLTITQEFRGLDEDGHLVVDTVISGTVPQVP-AGSTVIIEDYTELYQYTGPGELTSSSTRTYTVDG 160

                          170       180
                   ....*....|....*....|....*
gi 641649634   473 SDFEQQV--TVAQKFEFsQPCNKAA 495
Cdd:pfam07474  161 EGNTRTIsyTVNQTITY-QECRHAE 184
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 313-527 2.57e-40

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


Pssm-ID: 238158  Cd Length: 224  Bit Score: 148.99  E-value: 2.57e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634  313 VPVRVSGKVSIDVNGISMPE----SDLQAYVATMDGRVYMAISDVPSNLGFELQYLTVFPSVVAWLFSLHSENAFNGYQL 388
Cdd:cd00255     2 IPQRVNGKVSGNINVGQSPVefgdADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFALEQGGAKNGFSL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634  389 TGGVVNYTSEVTFPGTEHRITIHQRFFGLNSFDQLIMDATVQGTTPQVPLPhtrFTLPNDNHQQYTIANG----RMHSYY 464
Cdd:cd00255    82 TGGEFTRQAEVTFYTGGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAG---ATVHIEDYTELYHYTGpgvlTSSSTR 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 641649634  465 TYRYKQEGSDFEQQVTVAQKFEFSQPCNKAAKGFTSFMLQNSKAFAYYEEKVKILRLVSTNNI 527
Cdd:cd00255   159 EYTVDEGGESQTLSYQWNQTITYEECPHDDEAAPDLQQLLVARIFALYNPEEEILRFAITNSI 221
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
97-247 3.94e-34

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 128.31  E-value: 3.94e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634     97 FYANVDLRGSGQVYYREDRDPRTLAHANGLVSRFYpRYQGRFTATSVFVATWHRVGYYKKNADR-TNTFQVAVTTDGHET 175
Cdd:smart00539    2 FWADADTEGTGKVYYRETTDHAILDRATESVREGF-TDMGGFRAKSVVIVTWENVAAYGSQSSDgTNTFQAVLATDGSRT 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 641649634    176 FVQFAYPS-PIQWVQSFGGladEVGLPdakAQAGFSAADGRIHV-LRGSGSDQIHNLDRWSNTDAPGVWLYRVG 247
Cdd:smart00539   81 YAIFLYPSlGWTSDTTAGG---DDGVR---ARAGFNGGDGTFSYtLPASGEENIKNLAEGSNVGIPGRWMFRVD 148
G2F smart00682
G2 nidogen domain and fibulin;
314-527 2.19e-31

G2 nidogen domain and fibulin;


Pssm-ID: 214774  Cd Length: 227  Bit Score: 123.32  E-value: 2.19e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634    314 PVRVSGKVSIDVNGISMPES----DLQAYVATMDGRVYMAISDVPSNLGFELQYLTVFPSVVAWLFSLHSENAFNGYQLT 389
Cdd:smart00682    5 PQRVSGSVSGVINVGEFPVAfenaDLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAVNGFQLT 84

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634    390 GGVVNYTSEVTFPGTEHrITIHQRFFGLNSFDQLIMDATVQGTTPQVPLPHTrFTLPnDNHQQYTIAN-GRMHSYYTYRY 468
Cdd:smart00682   85 GGVFTRETEVTFAGGEI-LRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAE-VTIP-DYTEEYTYTGpGVLTTSSTREY 161

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 641649634    469 KQEGSDFeqQVTVAQKFEFSQPCNKAAKGFTSFMLQNSKAFAYYEEKVKILRLVSTNNI 527
Cdd:smart00682  162 TVDNQTH--SYTVDQTITFEECQHRDAFPPTTQQLHVSSVFVDYNDEERVLRFAAHNSV 218
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 161-248 1.10e-28

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 110.46  E-value: 1.10e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634   161 TNTFQVAVTTDGHETFVQFAYPSP-IQWVQSfGGLADEVGLPDAKAQAGFSAAD--GRIHVLRGSGSDQIHNLDRWSNTD 237
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYPDGgIQWTTG-KASGGTNGLGGTPAQAGFSAGDgdGRYYELPGSGTDSIRNLTETSNVG 79

                           90
                   ....*....|.
gi 641649634   238 APGVWLYRVGN 248
Cdd:pfam06119   80 VPGRWVFRIDS 90
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1140-1183 2.80e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.76  E-value: 2.80e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 641649634   1140 IIANSSLSNPRGIAVHPNRRKLFWSDWNRnsPKIEWSNLDGSQR 1183
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 582-617 2.30e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 51.06  E-value: 2.30e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 641649634   582 CQDRIDRCDPNAMCVNEVGTYSCQCRPGFEGNGYYC 617
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1115-1156 1.19e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 1.19e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 641649634  1115 RKIYWTDSGFK-RIMAADLsNGTHVTIIANSSLSNPRGIAVHP 1156
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADL-NGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
578-617 5.76e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 5.76e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 641649634    578 DVNECQDRiDRCDPNAMCVNEVGTYSCQCRPGFEgNGYYC 617
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNC 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1106-1138 8.47e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 8.47e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 641649634   1106 EGLTIDWVNRKIYWTDSGFKRIMAADLsNGTHV 1138
Cdd:smart00135   12 NGLAVDWIEGRLYWTDWGLDVIEVANL-DGTNR 43
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 578-612 8.49e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 8.49e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 641649634  578 DVNECQDRiDRCDPNAMCVNEVGTYSCQCRPGFEG 612
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
671-709 3.33e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 3.33e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 641649634    671 DVNECNIPEVCHRDSHCTNYPGTYACACNAGFIgDGLRC 709
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT-DGRNC 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 681-709 6.24e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.13  E-value: 6.24e-06
                           10        20
                   ....*....|....*....|....*....
gi 641649634   681 CHRDSHCTNYPGTYACACNAGFIGDGLRC 709
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1191-1223 1.00e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.74  E-value: 1.00e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 641649634   1191 NVKLPNSIAIDWYTDEMCWADAGLKSIECIGIE 1223
Cdd:smart00135    7 GLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1159-1202 1.86e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.92  E-value: 1.86e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 641649634  1159 RKLFWSDWNrNSPKIEWSNLDGSQREIFVQGpNVKLPNSIAIDW 1202
Cdd:pfam00058    1 GRLYWTDSS-LRASISSADLNGSDRKTLFTD-DLQHPNAIAVDP 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 671-705 2.41e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.41e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 641649634  671 DVNECNIPEVCHRDSHCTNYPGTYACACNAGFIGD 705
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 817-851 3.12e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.20  E-value: 3.12e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 641649634   817 CSKSN-ICDMHASCQIIEGHSICVCNSGYEGDGVIC 851
Cdd:pfam12947    1 CSDNNgGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 981-1017 3.95e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.82  E-value: 3.95e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 641649634   981 CVVNTSICHSLAQCmVDTSGHYICQCRQGYIGNGYYC 1017
Cdd:pfam12947    1 CSDNNGGCHPNATC-TNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 774-810 5.46e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.43  E-value: 5.46e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 641649634   774 CAEINT-CHAHAQCNFVSSQqrHKCQCNPGYEGDGYEC 810
Cdd:pfam12947    1 CSDNNGgCHPNATCTNTGGS--FTCTCNDGYTGDGVTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1114-1201 1.07e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.46  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634 1114 NRKIYWTDSGFKRIMAADLSNGTHVTIIanSSLSNPRGIAVHPNRRKLFWSDWNRNSpkieWSNLDGSQREIFVQGPNVK 1193
Cdd:COG3391    79 GRRLYVANSGSGRVSVIDLATGKVVATI--PVGGGPRGLAVDPDGGRLYVADSGNGR----VSVIDTATGKVVATIPVGA 152


                  ....*...
gi 641649634 1194 LPNSIAID 1201
Cdd:COG3391   153 GPHGIAVD 160
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1103-1170 3.02e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.83  E-value: 3.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 641649634 1103 TSTEGLTIDWVNRKIYWTDSGFKRIMAADLSNGTHVTIIANSslSNPRGIAVHPNRRKLFWSDWNRNS 1170
Cdd:COG3391   110 GGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG--AGPHGIAVDPDGKRLYVANSGSNT 175
 
Name Accession Description Interval E-value
G2F pfam07474
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ...
 313-495 4.79e-64

G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.


Pssm-ID: 462175  Cd Length: 184  Bit Score: 215.15  E-value: 4.79e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634   313 VPVRVSGKVSIDVNGISMPESDLQAYVATMDGRVYMAISDVPSNLGFELQYLTVFPSVVAWLFSLHSENAFNGYQLTGGV 392
Cdd:pfam07474    2 VPQRVNGKVSGTINGVEFGDADLHAYVVTNDGRAYTAISNIPPSLGPLLQLLSSIGGPIGWLFALEQGGAKNGFSLTGGV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634   393 VNYTSEVTFPGTEHRITIHQRFFGLNSFDQLIMDATVQGTTPQVPlPHTRFTLPNDNHQQYTIANGRMHSYYTYRYKQEG 472
Cdd:pfam07474   82 FNRTAEVTFPPTGERLTITQEFRGLDEDGHLVVDTVISGTVPQVP-AGSTVIIEDYTELYQYTGPGELTSSSTRTYTVDG 160

                          170       180
                   ....*....|....*....|....*
gi 641649634   473 SDFEQQV--TVAQKFEFsQPCNKAA 495
Cdd:pfam07474  161 EGNTRTIsyTVNQTITY-QECRHAE 184
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 313-527 2.57e-40

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


Pssm-ID: 238158  Cd Length: 224  Bit Score: 148.99  E-value: 2.57e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634  313 VPVRVSGKVSIDVNGISMPE----SDLQAYVATMDGRVYMAISDVPSNLGFELQYLTVFPSVVAWLFSLHSENAFNGYQL 388
Cdd:cd00255     2 IPQRVNGKVSGNINVGQSPVefgdADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFALEQGGAKNGFSL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634  389 TGGVVNYTSEVTFPGTEHRITIHQRFFGLNSFDQLIMDATVQGTTPQVPLPhtrFTLPNDNHQQYTIANG----RMHSYY 464
Cdd:cd00255    82 TGGEFTRQAEVTFYTGGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAG---ATVHIEDYTELYHYTGpgvlTSSSTR 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 641649634  465 TYRYKQEGSDFEQQVTVAQKFEFSQPCNKAAKGFTSFMLQNSKAFAYYEEKVKILRLVSTNNI 527
Cdd:cd00255   159 EYTVDEGGESQTLSYQWNQTITYEECPHDDEAAPDLQQLLVARIFALYNPEEEILRFAITNSI 221
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
97-247 3.94e-34

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 128.31  E-value: 3.94e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634     97 FYANVDLRGSGQVYYREDRDPRTLAHANGLVSRFYpRYQGRFTATSVFVATWHRVGYYKKNADR-TNTFQVAVTTDGHET 175
Cdd:smart00539    2 FWADADTEGTGKVYYRETTDHAILDRATESVREGF-TDMGGFRAKSVVIVTWENVAAYGSQSSDgTNTFQAVLATDGSRT 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 641649634    176 FVQFAYPS-PIQWVQSFGGladEVGLPdakAQAGFSAADGRIHV-LRGSGSDQIHNLDRWSNTDAPGVWLYRVG 247
Cdd:smart00539   81 YAIFLYPSlGWTSDTTAGG---DDGVR---ARAGFNGGDGTFSYtLPASGEENIKNLAEGSNVGIPGRWMFRVD 148
G2F smart00682
G2 nidogen domain and fibulin;
314-527 2.19e-31

G2 nidogen domain and fibulin;


Pssm-ID: 214774  Cd Length: 227  Bit Score: 123.32  E-value: 2.19e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634    314 PVRVSGKVSIDVNGISMPES----DLQAYVATMDGRVYMAISDVPSNLGFELQYLTVFPSVVAWLFSLHSENAFNGYQLT 389
Cdd:smart00682    5 PQRVSGSVSGVINVGEFPVAfenaDLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAVNGFQLT 84

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634    390 GGVVNYTSEVTFPGTEHrITIHQRFFGLNSFDQLIMDATVQGTTPQVPLPHTrFTLPnDNHQQYTIAN-GRMHSYYTYRY 468
Cdd:smart00682   85 GGVFTRETEVTFAGGEI-LRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAE-VTIP-DYTEEYTYTGpGVLTTSSTREY 161

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 641649634    469 KQEGSDFeqQVTVAQKFEFSQPCNKAAKGFTSFMLQNSKAFAYYEEKVKILRLVSTNNI 527
Cdd:smart00682  162 TVDNQTH--SYTVDQTITFEECQHRDAFPPTTQQLHVSSVFVDYNDEERVLRFAAHNSV 218
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 161-248 1.10e-28

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 110.46  E-value: 1.10e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634   161 TNTFQVAVTTDGHETFVQFAYPSP-IQWVQSfGGLADEVGLPDAKAQAGFSAAD--GRIHVLRGSGSDQIHNLDRWSNTD 237
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYPDGgIQWTTG-KASGGTNGLGGTPAQAGFSAGDgdGRYYELPGSGTDSIRNLTETSNVG 79

                           90
                   ....*....|.
gi 641649634   238 APGVWLYRVGN 248
Cdd:pfam06119   80 VPGRWVFRIDS 90
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1140-1183 2.80e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.76  E-value: 2.80e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 641649634   1140 IIANSSLSNPRGIAVHPNRRKLFWSDWNRnsPKIEWSNLDGSQR 1183
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 582-617 2.30e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 51.06  E-value: 2.30e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 641649634   582 CQDRIDRCDPNAMCVNEVGTYSCQCRPGFEGNGYYC 617
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1115-1156 1.19e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 1.19e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 641649634  1115 RKIYWTDSGFK-RIMAADLsNGTHVTIIANSSLSNPRGIAVHP 1156
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADL-NGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
578-617 5.76e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 5.76e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 641649634    578 DVNECQDRiDRCDPNAMCVNEVGTYSCQCRPGFEgNGYYC 617
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNC 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1106-1138 8.47e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 8.47e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 641649634   1106 EGLTIDWVNRKIYWTDSGFKRIMAADLsNGTHV 1138
Cdd:smart00135   12 NGLAVDWIEGRLYWTDWGLDVIEVANL-DGTNR 43
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 578-612 8.49e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 8.49e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 641649634  578 DVNECQDRiDRCDPNAMCVNEVGTYSCQCRPGFEG 612
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
671-709 3.33e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 3.33e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 641649634    671 DVNECNIPEVCHRDSHCTNYPGTYACACNAGFIgDGLRC 709
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT-DGRNC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
578-609 5.52e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 44.15  E-value: 5.52e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 641649634   578 DVNECQDRIDRCDPNAMCVNEVGTYSCQCRPG 609
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 681-709 6.24e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.13  E-value: 6.24e-06
                           10        20
                   ....*....|....*....|....*....
gi 641649634   681 CHRDSHCTNYPGTYACACNAGFIGDGLRC 709
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1191-1223 1.00e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.74  E-value: 1.00e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 641649634   1191 NVKLPNSIAIDWYTDEMCWADAGLKSIECIGIE 1223
Cdd:smart00135    7 GLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1159-1202 1.86e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.92  E-value: 1.86e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 641649634  1159 RKLFWSDWNrNSPKIEWSNLDGSQREIFVQGpNVKLPNSIAIDW 1202
Cdd:pfam00058    1 GRLYWTDSS-LRASISSADLNGSDRKTLFTD-DLQHPNAIAVDP 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 671-705 2.41e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.41e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 641649634  671 DVNECNIPEVCHRDSHCTNYPGTYACACNAGFIGD 705
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 817-851 3.12e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.20  E-value: 3.12e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 641649634   817 CSKSN-ICDMHASCQIIEGHSICVCNSGYEGDGVIC 851
Cdd:pfam12947    1 CSDNNgGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 981-1017 3.95e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.82  E-value: 3.95e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 641649634   981 CVVNTSICHSLAQCmVDTSGHYICQCRQGYIGNGYYC 1017
Cdd:pfam12947    1 CSDNNGGCHPNATC-TNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 774-810 5.46e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.43  E-value: 5.46e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 641649634   774 CAEINT-CHAHAQCNFVSSQqrHKCQCNPGYEGDGYEC 810
Cdd:pfam12947    1 CSDNNGgCHPNATCTNTGGS--FTCTCNDGYTGDGVTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1114-1201 1.07e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.46  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634 1114 NRKIYWTDSGFKRIMAADLSNGTHVTIIanSSLSNPRGIAVHPNRRKLFWSDWNRNSpkieWSNLDGSQREIFVQGPNVK 1193
Cdd:COG3391    79 GRRLYVANSGSGRVSVIDLATGKVVATI--PVGGGPRGLAVDPDGGRLYVADSGNGR----VSVIDTATGKVVATIPVGA 152


                  ....*...
gi 641649634 1194 LPNSIAID 1201
Cdd:COG3391   153 GPHGIAVD 160
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1063-1201 1.44e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 44.97  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641649634 1063 IGLAVDclEEQFYWSYIADQTIKSAKLNGSNVQEFiATEATSTE------GLTIDwVNRKIYWTDSGFKRIMAADLsNGT 1136
Cdd:cd14963   105 AGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLEF-GKPGSEPGelsypnGIAVD-EDGNIYVADSGNGRIQVFDK-NGK 179

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 641649634 1137 HVTIIANS-----SLSNPRGIAVHPnRRKLFWSDwnrN-SPKIEWSNLDGSQREIFVQ----GPNVKLPNSIAID 1201
Cdd:cd14963   180 FIKELNGSpdgksGFVNPRGIAVDP-DGNLYVVD---NlSHRVYVFDEQGKELFTFGGrgkdDGQFNLPNGLFID 250
EGF_CA pfam07645
Calcium-binding EGF domain;
671-701 5.51e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 5.51e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 641649634   671 DVNECNIP-EVCHRDSHCTNYPGTYACACNAG 701
Cdd:pfam07645    1 DVDECATGtHNCPANTVCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 581-615 1.23e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 1.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 641649634  581 ECQDRiDRCDPNAMCVNEVGTYSCQCRPGFEGNGY 615
Cdd:cd00053     1 ECAAS-NPCSNGGTCVNTPGSYRCVCPPGYTGDRS 34
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 674-706 1.87e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 1.87e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 641649634  674 ECNIPEVCHRDSHCTNYPGTYACACNAGFIGDG 706
Cdd:cd00053     1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1103-1170 3.02e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.83  E-value: 3.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 641649634 1103 TSTEGLTIDWVNRKIYWTDSGFKRIMAADLSNGTHVTIIANSslSNPRGIAVHPNRRKLFWSDWNRNS 1170
Cdd:COG3391   110 GGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG--AGPHGIAVDPDGKRLYVANSGSNT 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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