BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   5 VKLNIGGHVFVTRAETLQRIPHTRLSDLNPEVEEYDSESDEYYFDRDPEVFRPILNMYRSNELHLPRNMCGNALKLEMDY 84
Cdd:cd18317    1 VVLNVGGTRFELSRSTLLRFPDTRLGKLAKESHAYDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVCPASFKEELEF 80

                 ..
gi 676448627  85 WG 86
Cdd:cd18317   81 WG 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   5 VKLNIGGHVFVTRAETLQRIPHTRLSDLNPEVEEYDSESDEYYFDRDPEVFRPILNMYRSNELHLPRNMCGNALKLEMDY 84
Cdd:cd18317    1 VVLNVGGTRFELSRSTLLRFPDTRLGKLAKESHAYDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVCPASFKEELEF 80

                 ..
gi 676448627  85 WG 86
Cdd:cd18317   81 WG 82

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627  156 IWNTVYFGLILLSVSILVVESHKAFRIPNNDInmtsisfnisgkyrlyyttqllpiLYYLDVFCVSIFTIELSLHFLTSP 235
Cdd:pfam00520   3 YFELFILLLILLNTIFLALETYFQPEEPLTTV------------------------LEILDYVFTGIFTLEMLLKIIAAG 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627  236 YKLLFLKSWLNLLDALVIIAnwcnliveqnygkeLVSLLNRDLITAYRILKYISILRILRFFKLTERFHSLKIMTLAIKQ 315
Cdd:pfam00520  59 FKKRYFRSPWNILDFVVVLP--------------SLISLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIR 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627  316 SFRELFMMFMFIIVIATLYGCALFIMEFESEELTDIPIAIWWA-----------IITMTTVGYGDIIPKSDSGR------ 378
Cdd:pfam00520 125 SLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWENPDNGRTNfdnfpnaflwlFQTMTTEGWGDIMYDTIDGKgefway 204

                         250       260       270
                  ....*....|....*....|....*....|..
gi 676448627  379 -VIGVFCAISGLMVLSMPVAIIASNFSDYHER 409
Cdd:pfam00520 205 iYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236

voltage-gated potassium channel protein;

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 676448627 361 TMTTVGYGDIIPKSDSGRVIGVFCAISGLMVLSMPVAIIA 400
Cdd:PRK10537 179 TMSTVGYGDIVPVSESARLFTISVIILGITVFATSISAIF 218

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   5 VKLNIGGHVFVTRAETLQRIPHTRLSDLNPEVEEYDSESDEYYFDRDPEVFRPILNMYRSNELHLPRNMCGNALKLEMDY 84
Cdd:cd18317    1 VVLNVGGTRFELSRSTLLRFPDTRLGKLAKESHAYDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVCPASFKEELEF 80

                 ..
gi 676448627  85 WG 86
Cdd:cd18317   81 WG 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   5 VKLNIGGHVFVTRAETLQRIPHTRLSDL---NPEVEEYDSESDEYYFDRDPEVFRPILNMYRSNELHLPRNMCGNALKLE 81
Cdd:cd18379    1 IVINVGGVRHETYKSTLRNLPDTRLAWLtetEASAFDYDPVTGEFFFDRHPGVFAQILNYYRTGKLHCPADVCGPLFEEE 80

                         90
                 ....*....|....*.
gi 676448627  82 MDYWGIKVENIADCCW 97
Cdd:cd18379   81 LAFWGIDETQIEPCCW 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   2 SKKVKLNIGGHVFVTRAETLQRIPHTRL---------SDLNPEVEEYDSESDEYYFDRDPEVFRPILNMYRSNELHLPRN 72
Cdd:cd18378    1 SRRVLLNVGGVRHEVLWRTLDRLPRTRLgrlrecnthESLLELCDDYDLEDNEYFFDRHPGAFTSILNFYRTGKLHMPEE 80

                         90       100
                 ....*....|....*....|....
gi 676448627  73 MCGNALKLEMDYWGIKVENIADCC 96
Cdd:cd18378   81 MCVLSFSQELEYWGIDEIYLESCC 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   2 SKKVKLNIGGHVFVTRAETLQRIPHTRLSDL-NPEVE---EYDSESDEYYFDRDPEVFRPILNMYRSNELHLPRNMCGNA 77
Cdd:cd18414    2 SDRIVINVGGTRHETYRSTLRTLPGTRLAWLaEPDAHsnfDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPL 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 676448627  78 LKLEMDYWGIKVENIADCCWkIMYRVKQDSRIGAD 112
Cdd:cd18414   82 YEEELAFWGIDETDVEPCCW-MTYRQHRDAEEALD 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   7 LNIGGHVFVTRAETLQRIPHTRLSdlNPEVEEY-DSESDEYYFDRDPEVFRPILNMYRSNELHLPRNMCGNALKLEMDYW 85
Cdd:cd18419   39 LNVSGRRFQTWRTTLERYPDTLLG--STEKEFFfNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDEELAFY 116

                         90
                 ....*....|...
gi 676448627  86 GIKVENIADCCWK 98
Cdd:cd18419  117 GILPEIIGDCCYE 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   7 LNIGGHVFVTRAETLQRIPHTRLSDLNPEVEeYDSESDEYYFDRDPEVFRPILNMYRSNELHLPRNMCGNALKLEMDYWG 86
Cdd:cd18417   39 VNVSGRRFQTWKNTLDRYPDTLLGSSEKEFF-YNEDTQEYFFDRDPEMFRHILNFYRTGRLHYPRHECIQAFDEELSFYG 117

                         90
                 ....*....|
gi 676448627  87 IKVENIADCC 96
Cdd:cd18417  118 IIPEIIGDCC 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   5 VKLNIGGHVFVTRAETLQRIPHTRLSDLNPEVEE--YDSESDEYYFDRDPEVFRPILNMYRSNELHLPRNMCGNALKLEM 82
Cdd:cd18187    1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKPGREftFPNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGISIPDLREEC 80

                 ...
gi 676448627  83 DYW 85
Cdd:cd18187   81 DFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 1 (KCNB1); KCNB1, also called delayed rectifier potassium channel 1 (DRK1) or voltage-gated potassium channel subunit Kv2.1, mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB1 is involved in the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   2 SKKVKLNIGGHVFVTRAETLQRIPHTRLSDLNP--------EV-EEYDSESDEYYFDRDPEVFRPILNMYRSNELHLPRN 72
Cdd:cd18411    9 SRRVKLNVGGLAHEVLWRTLDRLPRTRLGKLRDcntheslmEIcDDYNLEENEYFFDRHPGAFTSILNFYRTGKLHMMEE 88

                         90       100
                 ....*....|....*....|....
gi 676448627  73 MCGNALKLEMDYWGIKVENIADCC 96
Cdd:cd18411   89 MCALSFSQELDYWGIDEIYLESCC 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shab and similar proteins; Shab is a slow delayed rectifier voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shab is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   2 SKKVKLNIGGHVFVTRAETLQRIPHTRLSDLNPE---------VEEYDSESDEYYFDRDPEVFRPILNMYRSNELHLPRN 72
Cdd:cd18413    1 NRRVVINVGGVKHEVLWRTLDRMPHTRLGKLRDSntheaivelCDDYSLADNEYFFDRHPRSFASILNFYRTGKLHLVEE 80

                         90       100
                 ....*....|....*....|....
gi 676448627  73 MCGNALKLEMDYWGIKVENIADCC 96
Cdd:cd18413   81 MCVLAFSDDLEYWGVDELYLESCC 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   2 SKKVKLNIGGHVFVTRAETLQRIPHTRLSDLNP--------EV-EEYDSESDEYYFDRDPEVFRPILNMYRSNELHLPRN 72
Cdd:cd18412   16 SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDcnthesllEVcDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEE 95

                         90       100
                 ....*....|....*....|....
gi 676448627  73 MCGNALKLEMDYWGIKVENIADCC 96
Cdd:cd18412   96 MCALSFGQELDYWGIDEIYLESCC 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   7 LNIGGHVFVTRAETLQRIPHTRLSDL----NPEVEEYDSESD----EYYFDRDPEVFRPILNMYRSNELHLPRNMCGNAL 78
Cdd:cd18424    3 INVGGSRFVLSQQVLSSHPETRLGKLavsvRDSVLELCDDANfvdnEYFFDRSSQAFKYIMNYYKTGHLHVMEELCAISF 82

                         90       100
                 ....*....|....*....|....*..
gi 676448627  79 KLEMDYWGIKVENIADCCWKIMYRVKQ 105
Cdd:cd18424   83 LQEIEYWGIDELSIDSCCRERYYRRKE 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 676448627   5 VKLNIGGHVFVTRAETLQRIPHTRLSDL-NPEVEEYDSESDEYYFDRDPEVFRPILNMYRSNELHLPRN 72
Cdd:cd18316    1 VKLNVGGTLFTTSRSTLLKDPDSLLAALfSGRWPLPRDEDGSIFIDRDPELFRHILNFLRTGKLPLPSD 69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   3 KKVKLNIGGHVFVTRAETLQRIPHTRLSDLN-----PEV----EEYDSESDEYYFDRDPEVFRPILNMYRSNELHLPRNM 73
Cdd:cd18423    2 REIIINVGGIKYLMPWSTLDEFPLTRLGKLKfcssyEEIvqicDDYDEDTNEFFFDRNPCAFRMIVSFLAAGKLRLLREM 81

                         90       100
                 ....*....|....*....|....*....
gi 676448627  74 CGNALKLEMDYWGIKVENIADCCWKIMYR 102
Cdd:cd18423   82 CALSFQEELTYWGIEEANLERCCLRKLFQ 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2; KCNG1, also called voltage-gated potassium channel subunit Kv6.1 or kH2, functions as a regulatory alpha-subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit or voltage-gated potassium channel subunit Kv6.2, is a new gamma-subunit of voltage-gated potassium channels that can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG1 and KCNG2 are regulatory alpha subunits and do not form homomultimers. They form heteromultimers (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   5 VKLNIGGHVFVTRAETLQRIPHTRLSDLN-----PEV----EEYDSESDEYYFDRDPEVFRPILNMYRSNELHLPRNMCG 75
Cdd:cd18421    6 VIINVGGIKYRIPWTTLEEFPLTRLGQLKscnnfDEImdicDDYDVTCNEFFFDRNPCAFRTILTFLRAGKLRLLREMCA 85

                         90       100
                 ....*....|....*....|.
gi 676448627  76 NALKLEMDYWGIKVENIADCC 96
Cdd:cd18421   86 LSFQEELLYWGIEEENLEWCC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   5 VKLNIGGHVFVTRAETLQRIPHTRLSD-LNPEVEEYDSESDEYYFDRDPEVFRPILNMYRSNELHLpRNMCGNALKLEMD 83
Cdd:cd18363    4 INLNVGGKRFSTSRQTLTWIPDSFFTSlLSGRISSLKDETGAIFIDRDPKLFSIILNYLRTKEIDL-RNVDISSLRHEAE 82

                 ....
gi 676448627  84 YWGI 87
Cdd:cd18363   83 FYGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   5 VKLNIGGHVFVTRAETLQRIPHTRLSDL-NPEVEEYDSESDEYYFDRDPEVFRPILNMYRSNELHlPRNMCGNALKLEMD 83
Cdd:cd18393    4 IHLNVGGKRFSTSRQTLTWIPDSFFSSLlSGRISTLKDETGAIFIDRDPTVFAPILNFLRTKELD-PRGIHVSLLLHEAQ 82

                 ....
gi 676448627  84 YWGI 87
Cdd:cd18393   83 FYGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6); KCTD6, also called KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3 (KCASH3), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5) as well as suppressing histone deacetylase and Hedgehog activity in medulloblastoma. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   1 MSKKVKLNIGGHVFVTRAETLQRIPHTRLSDL----NPEVEeyDSESDeYYFDRDPEVFRPILNMYRSNELHLPRNMCG- 75
Cdd:cd18394    1 MTDPVTLNVGGHLYTTSLSTLTRYPDSMLGAMfrgdFPTAR--DSQGN-YFIDRDGPLFRYILNFLRTSELTLPVDFKEf 77

                         90
                 ....*....|...
gi 676448627  76 NALKLEMDYWGIK 88
Cdd:cd18394   78 DLLRKEADFYQIE 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   3 KKVKLNIGGHVFVTRAETLQRIPHTRLSDLNPEVEEYDSESDE---YYFDRDPEVFRPILNMYRSNELHLPRNMCGNALK 79
Cdd:cd18389    1 KWVRLNVGGTYFVSTKQTLCRDPKSFLYRLCQEDPDLDSDKDEtgaYLIDRDPTYFGPILNYLRHGKLIINKELAEEGVL 80

                 ....*...
gi 676448627  80 LEMDYWGI 87
Cdd:cd18389   81 EEAEFYNI 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   2 SKKVKLNIGGHVFVTRAETLQRIPHT---RLSDLNPEVEEYDSESDEYYFDRDPEVFRPILNMYRSNELHLPRNMCGNAL 78
Cdd:cd18390    4 SKWVRLNVGGTYFLTTRQTLCRDPKSflyRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGV 83

                 ....*....
gi 676448627  79 KLEMDYWGI 87
Cdd:cd18390   84 LEEAEFYNI 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 14 (KCTD14); KCTD14 is a BTB/POZ domain-containing protein with unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 676448627   2 SKKVKLNIGGHVFVTRAETLQRIPHTRLSDL--NPEVEEYDSESdEYYFDRDPEVFRPILNMYRSNEL 67
Cdd:cd18371    1 SQVVSLNVGGHIYTTTLSTLRKFPGSKLAELfnGQPKLRTDSEG-RYFIDRDGTYFRYILEYLRTNQV 67

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   5 VKLNIGGHVFVTRAETLQRIPHTRLSDLNPEVEEYDSESDEYYF-DRDPEVFRPILNMYRSNELHlPRNMCGNALKlEMD 83
Cdd:cd18366    6 VPLNVGGMHFTTRLSTLRKYEDSMLAAMFSGRHHIPKDSEGRYFiDRDGSYFGYILNFLRDGDLP-PRERARAVYK-EAQ 83

                 ....
gi 676448627  84 YWGI 87
Cdd:cd18366   84 YYGI 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 676448627   5 VKLNIGGHVFVTRAETLQRIPHTRL----SDLNPEVEEYDSESdEYYFDRDPEVFRPILNMYRSNELHLPRN 72
Cdd:cd18367    5 VELNVGGQVYTTSLSTLIKDPDSLLgrmfSGKNRQELARDSKG-RYFLDRDGVLFRYILDYLRNQKLVLPEN 75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 9 (KCTD9); KCTD9 is a BTB/POZ domain-containing protein that contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. It functions as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD9 BTB domain forms a pentameric structure.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   5 VKLNIGGHVFVTRAETL-QRIPHTRLSDLNPEVEEYDSESDE---YYFDRDPEVFRPILNMYRSNELHLPRNMCGNALKL 80
Cdd:cd18368    3 IKLNVGGRIFTTTRSTLvKKEPDSMLARMFSDDSTWPSSRDEngaYLIDRSPEYFEPILNYLRHGQLILNDGLNPLGVLE 82

                 ....*...
gi 676448627  81 EMDYWGIK 88
Cdd:cd18368   83 EAKFFGIQ 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   5 VKLNIGGHVFVTRAETLQRIPHTRLSDLNPEVEE--YDSESDEYYFDRDPEVFRPILNMYRSNELHLPRN 72
Cdd:cd18388    4 VHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPivLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPED 73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21); KCTD21, also calledz KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 2 (KCASH2), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676448627   5 VKLNIGGHVFVTRAETLQRIPHTRLSDLNPEveEYDSESDE---YYFDRDPEVFRPILNMYRSNELHLPRNMCG-NALKL 80
Cdd:cd18395    3 ITLNVGGKLYTTSLATLTRYPDSMLGAMFSG--KFPTKKDSqgnCFIDRDGKIFRYILNFLRTSHLDLPEDFQEmGLLKR 80

                 ....*...
gi 676448627  81 EMDYWGIK 88
Cdd:cd18395   81 EADFYQIQ 88

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 676448627  361 TMTTVGYGDIIPKSDSGRVIGVFCAISGLMVLSMPVAIIASNFSD 405
Cdd:pfam07885  34 TLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78