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Conserved domains on  [gi|741929732|ref|XP_010804360|]
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toll-like receptor 6 isoform X1 [Bos taurus]

Protein Classification

toll-like receptor( domain architecture ID 11471523)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-784 9.67e-38

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 137.45  E-value: 9.67e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732   641 QFHAFISYSEHDsaWVKNELIPNLEK--EDIRICLHERNFVAGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 741929732   719 AHHNLFHEGSNNLILILLEPIPQnTIPDRYHKLRALMaQRTYLEWPKEKNKHglFWANIRAAFNIK 784
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPS-DVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-165 2.63e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 2.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  35 VVDMSKTSLIHVPKDLP--PKTKVLDLSQNNISELHlSDISFLSGLRVLRLSHNRIQGLDISIFKFNHdLEYLDLSHNQL 112
Cdd:COG4886  117 SLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQI 194
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 741929732 113 QKIScHPIT--TTLKHLDLSFNDFDALPicKEFGNLTQLNFLGLSATKLQQLDLL 165
Cdd:COG4886  195 TDLP-EPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTDLPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
237-531 7.38e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 7.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 237 VLLKFLSGLTGGPTLLNFTLNHMETTWKCLVKVFQFLWPKPIEYLNIYNLTIVESIDEEVFTYYKTTLKALKIEHITNKV 316
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 317 FIFSQTALYTVFSEMNILMLTISDTRFIHMLcpqepSTFKFLNFTQNSFTDsVFQNCDTLARLETLILQKNELKDLfKTS 396
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDL-PEP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 397 LmtKDMLSLETLDVSWNSLEY-DRSNGNCSwvgSIVVLNLSSNALTD--SVFRCLPpRIKVLDLHNNRIRSIPKDVTGLE 473
Cdd:COG4886  155 L--GNLTNLKSLDLSNNQLTDlPEELGNLT---NLKELDLSNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLT 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 741929732 474 TLQELNLASNSLAHLPGCGIFSSLSILIIDYNSISNPSadFFQSCQKIRSLKVGNNPF 531
Cdd:COG4886  229 NLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-582 3.68e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 3.68e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 741929732   529 NPFQCSCELRDFIQSVGQvssDVVEGWPESYKCDYPESYKGtPLKDFQVSELSC 582
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-784 9.67e-38

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 137.45  E-value: 9.67e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732   641 QFHAFISYSEHDsaWVKNELIPNLEK--EDIRICLHERNFVAGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 741929732   719 AHHNLFHEGSNNLILILLEPIPQnTIPDRYHKLRALMaQRTYLEWPKEKNKHglFWANIRAAFNIK 784
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPS-DVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
642-774 1.82e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 88.96  E-value: 1.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  642 FHAFISYSEHDS-AWVKNELIPNLEKEDIRICLHERNFVAGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 720
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  721 HNLFhEGSNNLILILLEPIPQ------NTIPDRYHKLRALMAQRTYLEWPKEKNKHGLFW 774
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSdvrkqtGSFGKAFKKHKKVLTEEKVLKWRGALNEVANIW 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-165 2.63e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 2.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  35 VVDMSKTSLIHVPKDLP--PKTKVLDLSQNNISELHlSDISFLSGLRVLRLSHNRIQGLDISIFKFNHdLEYLDLSHNQL 112
Cdd:COG4886  117 SLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQI 194
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 741929732 113 QKIScHPIT--TTLKHLDLSFNDFDALPicKEFGNLTQLNFLGLSATKLQQLDLL 165
Cdd:COG4886  195 TDLP-EPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTDLPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
237-531 7.38e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 7.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 237 VLLKFLSGLTGGPTLLNFTLNHMETTWKCLVKVFQFLWPKPIEYLNIYNLTIVESIDEEVFTYYKTTLKALKIEHITNKV 316
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 317 FIFSQTALYTVFSEMNILMLTISDTRFIHMLcpqepSTFKFLNFTQNSFTDsVFQNCDTLARLETLILQKNELKDLfKTS 396
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDL-PEP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 397 LmtKDMLSLETLDVSWNSLEY-DRSNGNCSwvgSIVVLNLSSNALTD--SVFRCLPpRIKVLDLHNNRIRSIPKDVTGLE 473
Cdd:COG4886  155 L--GNLTNLKSLDLSNNQLTDlPEELGNLT---NLKELDLSNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLT 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 741929732 474 TLQELNLASNSLAHLPGCGIFSSLSILIIDYNSISNPSadFFQSCQKIRSLKVGNNPF 531
Cdd:COG4886  229 NLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
76-134 1.83e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.83e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741929732   76 SGLRVLRLSHNRIQGLDISIFKFNHDLEYLDLSHNQLQKISCHPIT--TTLKHLDLSFNDF 134
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSglPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-582 3.68e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 3.68e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 741929732   529 NPFQCSCELRDFIQSVGQvssDVVEGWPESYKCDYPESYKGtPLKDFQVSELSC 582
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
55-141 9.88e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 9.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  55 KVLDLSQNNIS------------ELHLSD---------------ISFLSG-LRVLRLSHNRIQglDISIFKFNHDLEYLD 106
Cdd:cd21340   71 KKLYLGGNRISvveglenltnleELHIENqrlppgekltfdprsLAALSNsLRVLNISGNNID--SLEPLAPLRNLEQLD 148
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 741929732 107 LSHNQLQKIS--CHPITT--TLKHLDLSFNdfdalPICK 141
Cdd:cd21340  149 ASNNQISDLEelLDLLSSwpSLRELDLTGN-----PVCK 182
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
46-494 1.57e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  46 VPKDLPPKTKVLDLSQNNISELHLSDISFLSGLRVLRLSHNRIQG-LDISIFKFNhDLEYLDLSHNQL---------QKI 115
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGkIPNSLTNLT-SLEFLTLASNQLvgqiprelgQMK 212
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 116 SCHPI-----------------TTTLKHLDLSFNDFDAlPICKEFGNLTQLNFLGLSATKLQqlDLLPIAHLHLS-CILL 177
Cdd:PLN00113 213 SLKWIylgynnlsgeipyeiggLTSLNHLDLVYNNLTG-PIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQkLISL 289
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 178 DLEDYMKENKKESL--QILNTKKLHLvFHPNsfFSVQVDISANSLGCLQLTNIKLNDYNCQVLLKFlsGLTGGPTLLNFT 255
Cdd:PLN00113 290 DLSDNSLSGEIPELviQLQNLEILHL-FSNN--FTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNL--GKHNNLTVLDLS 364
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 256 LNHmettwkclvkvfqfLWPKPIEYL----NIYNLTIVE-SIDEEVFTYYkTTLKALKIEHITNKVFifsQTALYTVFSE 330
Cdd:PLN00113 365 TNN--------------LTGEIPEGLcssgNLFKLILFSnSLEGEIPKSL-GACRSLRRVRLQDNSF---SGELPSEFTK 426
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 331 MNIL-MLTISDTRFIHMLCPQ--EPSTFKFLNFTQNSFTDSVFQNCDTlARLETLILQKNELKDLFKTSLMTkdMLSLET 407
Cdd:PLN00113 427 LPLVyFLDISNNNLQGRINSRkwDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGS--LSELMQ 503
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 408 LDVSWNSL--EYDRSNGNCSwvgSIVVLNLSSNALTDSVFRCLP--PRIKVLDLHNNRIR-SIPKDVTGLETLQELNLAS 482
Cdd:PLN00113 504 LKLSENKLsgEIPDELSSCK---KLVSLDLSHNQLSGQIPASFSemPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISH 580
                        490
                 ....*....|...
gi 741929732 483 NSL-AHLPGCGIF 494
Cdd:PLN00113 581 NHLhGSLPSTGAF 593
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-138 2.00e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  42 SLIHVPKDLPPKTKVLDLSQNNISEL--HLSdisflSGLRVLRLSHNRIQGLDISIfkfNHDLEYLDLSHNQLQKISCHp 119
Cdd:PRK15370 231 QLTSIPATLPDTIQEMELSINRITELpeRLP-----SALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAH- 301
                         90
                 ....*....|....*....
gi 741929732 120 ITTTLKHLDLSFNDFDALP 138
Cdd:PRK15370 302 LPSGITHLNVQSNSLTALP 320
LRR_8 pfam13855
Leucine rich repeat;
450-507 1.56e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741929732  450 PRIKVLDLHNNRIRSIPKDV-TGLETLQELNLASNSLAHLPGCGIF--SSLSILIIDYNSI 507
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSglPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
363-498 5.47e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 5.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 363 NSFTDS---VFQNCDTLARLETLILQKNELKDL---FKTSLMTKDMLSLETLDVSWNSLEYDRSN---GNCSWVGSIVVL 433
Cdd:cd00116   91 NALGPDgcgVLESLLRSSSLQELKLNNNGLGDRglrLLAKGLKDLPPALEKLVLGRNRLEGASCEalaKALRANRDLKEL 170
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 741929732 434 NLSSNALTDSVFRCLPP------RIKVLDLHNNRIRS--------IPKDvtgLETLQELNLASNSLAHLPGCGIFSSLS 498
Cdd:cd00116  171 NLANNGIGDAGIRALAEglkancNLEVLDLNNNGLTDegasalaeTLAS---LKSLEVLNLGDNNLTDAGAAALASALL 246
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-784 9.67e-38

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 137.45  E-value: 9.67e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732   641 QFHAFISYSEHDsaWVKNELIPNLEK--EDIRICLHERNFVAGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 741929732   719 AHHNLFHEGSNNLILILLEPIPQnTIPDRYHKLRALMaQRTYLEWPKEKNKHglFWANIRAAFNIK 784
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPS-DVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
642-774 1.82e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 88.96  E-value: 1.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  642 FHAFISYSEHDS-AWVKNELIPNLEKEDIRICLHERNFVAGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 720
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  721 HNLFhEGSNNLILILLEPIPQ------NTIPDRYHKLRALMAQRTYLEWPKEKNKHGLFW 774
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSdvrkqtGSFGKAFKKHKKVLTEEKVLKWRGALNEVANIW 139
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
645-738 2.70e-17

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 78.51  E-value: 2.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  645 FISYSEHDSAWVKnELIPNLEKEDIRICLHERNFVAGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHnlF 724
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA--D 78
                          90
                  ....*....|....
gi 741929732  725 HEGSNNLILILLEP 738
Cdd:pfam13676  79 PEGRKRLIPVRLEC 92
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-165 2.63e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 2.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  35 VVDMSKTSLIHVPKDLP--PKTKVLDLSQNNISELHlSDISFLSGLRVLRLSHNRIQGLDISIFKFNHdLEYLDLSHNQL 112
Cdd:COG4886  117 SLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQI 194
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 741929732 113 QKIScHPIT--TTLKHLDLSFNDFDALPicKEFGNLTQLNFLGLSATKLQQLDLL 165
Cdd:COG4886  195 TDLP-EPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTDLPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
237-531 7.38e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 7.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 237 VLLKFLSGLTGGPTLLNFTLNHMETTWKCLVKVFQFLWPKPIEYLNIYNLTIVESIDEEVFTYYKTTLKALKIEHITNKV 316
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 317 FIFSQTALYTVFSEMNILMLTISDTRFIHMLcpqepSTFKFLNFTQNSFTDsVFQNCDTLARLETLILQKNELKDLfKTS 396
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDL-PEP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 397 LmtKDMLSLETLDVSWNSLEY-DRSNGNCSwvgSIVVLNLSSNALTD--SVFRCLPpRIKVLDLHNNRIRSIPKDVTGLE 473
Cdd:COG4886  155 L--GNLTNLKSLDLSNNQLTDlPEELGNLT---NLKELDLSNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLT 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 741929732 474 TLQELNLASNSLAHLPGCGIFSSLSILIIDYNSISNPSadFFQSCQKIRSLKVGNNPF 531
Cdd:COG4886  229 NLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
356-546 1.70e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 1.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 356 KFLNFTQNSFTD--SVFQNcdtLARLETLILQKNELKDLfKTSLmtKDMLSLETLDVSWNSLEY-DRSNGNCSwvgSIVV 432
Cdd:COG4886  139 KELDLSNNQLTDlpEPLGN---LTNLKSLDLSNNQLTDL-PEEL--GNLTNLKELDLSNNQITDlPEPLGNLT---NLEE 209
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 433 LNLSSNALTD---SVFRClpPRIKVLDLHNNRIRSIPkDVTGLETLQELNLASNSLAHLPGCGIFSSLSILIIDYNSISN 509
Cdd:COG4886  210 LDLSGNQLTDlpePLANL--TNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD 286
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 741929732 510 PSADFFQSCQKIRSLKVGNNPFQCSCELRDFIQSVGQ 546
Cdd:COG4886  287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-238 1.14e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 1.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  55 KVLDLSQNNISELHLSdISFLSGLRVLRLSHNRIQglDISIFKFNHDLEYLDLSHNQLQKISCHPITTTLKHLDLSFNDF 134
Cdd:COG4886  208 EELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT--DLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 135 DALpickEFGNLTQLNFLGLSATKLQQLDLLPIAHLHLSCILLDLEDYMKENKKESLQILNTKKLHLVFHPNSFFSVQVD 214
Cdd:COG4886  285 TDL----KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLS 360
                        170       180
                 ....*....|....*....|....
gi 741929732 215 ISANSLGCLQLTNIKLNDYNCQVL 238
Cdd:COG4886  361 LLLTLLLTLGLLGLLEATLLTLAL 384
LRR_8 pfam13855
Leucine rich repeat;
76-134 1.83e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.83e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741929732   76 SGLRVLRLSHNRIQGLDISIFKFNHDLEYLDLSHNQLQKISCHPIT--TTLKHLDLSFNDF 134
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSglPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
52-112 3.16e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 3.16e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741929732   52 PKTKVLDLSQNNISELHLSDISFLSGLRVLRLSHNRIQGLDISIFKFNHDLEYLDLSHNQL 112
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-582 3.68e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 3.68e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 741929732   529 NPFQCSCELRDFIQSVGQvssDVVEGWPESYKCDYPESYKGtPLKDFQVSELSC 582
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-163 7.18e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.24  E-value: 7.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  39 SKTSLIHVPKDLPPKTKVLDLSQNNISELHLSDISFLSGLRVLRLSHNRiqgldiSIFKFNhDLEYLDLSHNQLQKIsch 118
Cdd:COG4886   59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLT-NLESLDLSGNQLTDL--- 128
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 741929732 119 PIT----TTLKHLDLSFNDFDALPicKEFGNLTQLNFLGLSATKLQQLD 163
Cdd:COG4886  129 PEElanlTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLTDLP 175
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
55-141 9.88e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 9.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  55 KVLDLSQNNIS------------ELHLSD---------------ISFLSG-LRVLRLSHNRIQglDISIFKFNHDLEYLD 106
Cdd:cd21340   71 KKLYLGGNRISvveglenltnleELHIENqrlppgekltfdprsLAALSNsLRVLNISGNNID--SLEPLAPLRNLEQLD 148
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 741929732 107 LSHNQLQKIS--CHPITT--TLKHLDLSFNdfdalPICK 141
Cdd:cd21340  149 ASNNQISDLEelLDLLSSwpSLRELDLTGN-----PVCK 182
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
46-494 1.57e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  46 VPKDLPPKTKVLDLSQNNISELHLSDISFLSGLRVLRLSHNRIQG-LDISIFKFNhDLEYLDLSHNQL---------QKI 115
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGkIPNSLTNLT-SLEFLTLASNQLvgqiprelgQMK 212
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 116 SCHPI-----------------TTTLKHLDLSFNDFDAlPICKEFGNLTQLNFLGLSATKLQqlDLLPIAHLHLS-CILL 177
Cdd:PLN00113 213 SLKWIylgynnlsgeipyeiggLTSLNHLDLVYNNLTG-PIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQkLISL 289
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 178 DLEDYMKENKKESL--QILNTKKLHLvFHPNsfFSVQVDISANSLGCLQLTNIKLNDYNCQVLLKFlsGLTGGPTLLNFT 255
Cdd:PLN00113 290 DLSDNSLSGEIPELviQLQNLEILHL-FSNN--FTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNL--GKHNNLTVLDLS 364
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 256 LNHmettwkclvkvfqfLWPKPIEYL----NIYNLTIVE-SIDEEVFTYYkTTLKALKIEHITNKVFifsQTALYTVFSE 330
Cdd:PLN00113 365 TNN--------------LTGEIPEGLcssgNLFKLILFSnSLEGEIPKSL-GACRSLRRVRLQDNSF---SGELPSEFTK 426
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 331 MNIL-MLTISDTRFIHMLCPQ--EPSTFKFLNFTQNSFTDSVFQNCDTlARLETLILQKNELKDLFKTSLMTkdMLSLET 407
Cdd:PLN00113 427 LPLVyFLDISNNNLQGRINSRkwDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGS--LSELMQ 503
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 408 LDVSWNSL--EYDRSNGNCSwvgSIVVLNLSSNALTDSVFRCLP--PRIKVLDLHNNRIR-SIPKDVTGLETLQELNLAS 482
Cdd:PLN00113 504 LKLSENKLsgEIPDELSSCK---KLVSLDLSHNQLSGQIPASFSemPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISH 580
                        490
                 ....*....|...
gi 741929732 483 NSL-AHLPGCGIF 494
Cdd:PLN00113 581 NHLhGSLPSTGAF 593
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-138 2.00e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  42 SLIHVPKDLPPKTKVLDLSQNNISEL--HLSdisflSGLRVLRLSHNRIQGLDISIfkfNHDLEYLDLSHNQLQKISCHp 119
Cdd:PRK15370 231 QLTSIPATLPDTIQEMELSINRITELpeRLP-----SALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAH- 301
                         90
                 ....*....|....*....
gi 741929732 120 ITTTLKHLDLSFNDFDALP 138
Cdd:PRK15370 302 LPSGITHLNVQSNSLTALP 320
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
379-507 2.99e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 2.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 379 LETLILQKNELKDLfktslmtKDML--SLETLDVSWNSLEYDRSNgncsWVGSIVVLNLSSNALT--------------- 441
Cdd:PRK15370 264 LQSLDLFHNKISCL-------PENLpeELRYLSVYDNSIRTLPAH----LPSGITHLNVQSNSLTalpetlppglktlea 332
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741929732 442 -DSVFRCLP----PRIKVLDLHNNRIRSIPKDVTglETLQELNLASNSLAHLPGcGIFSSLSILIIDYNSI 507
Cdd:PRK15370 333 gENALTSLPaslpPELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPE-NLPAALQIMQASRNNL 400
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
353-565 1.96e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 353 STFKFLNFTQNSFTDSVFQNCDTLARLETLILQKNELKDLFKTSLMtkDMLSLETLDVSWNSLEYDRSNgNCSWVGSIVV 432
Cdd:PLN00113 236 TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF--SLQKLISLDLSDNSLSGEIPE-LVIQLQNLEI 312
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 433 LNLSSNALTDSVFRCLP--PRIKVLDLHNNRIR-SIPKDVTGLETLQELNLASNSLAHLPGCGIFSS--LSILIIDYNSI 507
Cdd:PLN00113 313 LHLFSNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSgnLFKLILFSNSL 392
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 741929732 508 SNPSADFFQSCQKIRSLKVGNNPFqcSCEL-RDF--IQSVG--QVSSDVVEGWPESYKCDYPE 565
Cdd:PLN00113 393 EGEIPKSLGACRSLRRVRLQDNSF--SGELpSEFtkLPLVYflDISNNNLQGRINSRKWDMPS 453
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
378-529 3.11e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 3.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 378 RLETLILQKNELKDL-------FKT-SLMTKDMLSL-ETLDVSWNSLEYDRSNGNC---SWVGSIVVLNLSSNALTdSVF 445
Cdd:PRK15370 200 QITTLILDNNELKSLpenlqgnIKTlYANSNQLTSIpATLPDTIQEMELSINRITElpeRLPSALQSLDLFHNKIS-CLP 278
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 446 RCLPPRIKVLDLHNNRIRSIPKDVTglETLQELNLASNSLAHLPGCgIFSSLSILIIDYNSISNPSADFfqsCQKIRSLK 525
Cdd:PRK15370 279 ENLPEELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPET-LPPGLKTLEAGENALTSLPASL---PPELQVLD 352

                 ....
gi 741929732 526 VGNN 529
Cdd:PRK15370 353 VSKN 356
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
53-531 1.30e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  53 KTKVLDLSQNNISELHLSDISFLSGLRVLRLSHNRIQG-LDISIFKFNHDLEYLDLSHNQLQKISCHPITTTLKHLDLSF 131
Cdd:PLN00113  70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSN 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 132 NDFDAlPICKEFGNLTQLNFLGLSATKLqqLDLLPIAHLHLScilldledymkenkkeSLQILNTKKLHLVFhpnsffsv 211
Cdd:PLN00113 150 NMLSG-EIPNDIGSFSSLKVLDLGGNVL--VGKIPNSLTNLT----------------SLEFLTLASNQLVG-------- 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 212 QVDISANSLGCLQLTNIKLNDYNCQVLLKfLSGLTggptllnfTLNHMETTWKCLVKvfqflwPKPIEYLNIYNLtives 291
Cdd:PLN00113 203 QIPRELGQMKSLKWIYLGYNNLSGEIPYE-IGGLT--------SLNHLDLVYNNLTG------PIPSSLGNLKNL----- 262
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 292 idEEVFTYykttlkalkiehiTNKvfiFSQTALYTVFSEMNILMLTISDTrFIHMLCPQ---EPSTFKFLNFTQNSFTDS 368
Cdd:PLN00113 263 --QYLFLY-------------QNK---LSGPIPPSIFSLQKLISLDLSDN-SLSGEIPElviQLQNLEILHLFSNNFTGK 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 369 VFQNCDTLARLETLILQKNEL-----KDLFKTSlmtkdmlSLETLDVSWNSLEYDRSNGNCSwVGSIVVLNLSSNALTDS 443
Cdd:PLN00113 324 IPVALTSLPRLQVLQLWSNKFsgeipKNLGKHN-------NLTVLDLSTNNLTGEIPEGLCS-SGNLFKLILFSNSLEGE 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 444 VFRCLPP--RIKVLDLHNNRIR-SIPKDVTGLETLQELNLASNSLA--------HLPgcgifsSLSILIIDYNSISNPSA 512
Cdd:PLN00113 396 IPKSLGAcrSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwDMP------SLQMLSLARNKFFGGLP 469
                        490
                 ....*....|....*....
gi 741929732 513 DFFQScQKIRSLKVGNNPF 531
Cdd:PLN00113 470 DSFGS-KRLENLDLSRNQF 487
LRR_8 pfam13855
Leucine rich repeat;
450-507 1.56e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741929732  450 PRIKVLDLHNNRIRSIPKDV-TGLETLQELNLASNSLAHLPGCGIF--SSLSILIIDYNSI 507
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSglPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
55-125 1.82e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 1.82e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 741929732  55 KVLDLSQNNISELhlSDISFLSGLRVLRLSHNRIQGLD---ISIFKFNHdLEYLDLSHNqlqkischPITTTLK 125
Cdd:cd21340  123 RVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEellDLLSSWPS-LRELDLTGN--------PVCKKPK 185
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
43-164 7.66e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 7.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  43 LIHVPKDLPPKTKVLDLSQNNI----SELHLSDISFLSGLRVLRLSHNRIQGLDIS----IFKFNHDLEYLDLSHNQLQK 114
Cdd:cd00116  128 LAKGLKDLPPALEKLVLGRNRLegasCEALAKALRANRDLKELNLANNGIGDAGIRalaeGLKANCNLEVLDLNNNGLTD 207
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 741929732 115 ISCHPITTTLKH------LDLSFNDFDALPICkefgnlTQLNFLGLSATKLQQLDL 164
Cdd:cd00116  208 EGASALAETLASlkslevLNLGDNNLTDAGAA------ALASALLSPNISLLTLSL 257
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
57-159 2.12e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732  57 LDLSQNNISELHLSDIS-FLSG---LRVLRLSHNRI---------QGLdisifKFNHDLEYLDLSHNQLQKISCHPIT-- 121
Cdd:COG5238  269 LYLSGNQIGAEGAIALAkALQGnttLTSLDLSVNRIgdegaialaEGL-----QGNKTLHTLNLAYNGIGAQGAIALAka 343
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 741929732 122 ----TTLKHLDLSFN---DFDALPICKEFGNLTQLNFLGLSATKL 159
Cdd:COG5238  344 lqenTTLHSLDLSDNqigDEGAIALAKYLEGNTTLRELNLGKNNI 388
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
363-498 5.47e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 5.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741929732 363 NSFTDS---VFQNCDTLARLETLILQKNELKDL---FKTSLMTKDMLSLETLDVSWNSLEYDRSN---GNCSWVGSIVVL 433
Cdd:cd00116   91 NALGPDgcgVLESLLRSSSLQELKLNNNGLGDRglrLLAKGLKDLPPALEKLVLGRNRLEGASCEalaKALRANRDLKEL 170
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 741929732 434 NLSSNALTDSVFRCLPP------RIKVLDLHNNRIRS--------IPKDvtgLETLQELNLASNSLAHLPGCGIFSSLS 498
Cdd:cd00116  171 NLANNGIGDAGIRALAEglkancNLEVLDLNNNGLTDegasalaeTLAS---LKSLEVLNLGDNNLTDAGAAALASALL 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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