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Conserved domains on  [gi|755497391|ref|XP_011237369|]
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snRNA-activating protein complex subunit 4 isoform X6 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 314-374 3.37e-14

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 68.11  E-value: 3.37e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755497391   314 WAPEEDAKLLQAVAKYGaQDWFKIREEVPGRSDAQCRDRYIRRLHFSLKKGRWNAKEEQQL 374
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
363-406 1.38e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


:

Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 66.09  E-value: 1.38e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 755497391    363 KGRWNAKEEQQLIQLIEKYGVGHWARIASELPHRSGSQCLSKWK 406
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWR 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
204-253 9.42e-08

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


:

Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 49.53  E-value: 9.42e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 755497391    204 KQEWSTEEVERLKAIAATHGHLEWHLVAEELGTsRSAFQCLQKFQQYNKT 253
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPG-RTAEQCRERWRNLLKP 49
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 717-1076 3.50e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 3.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  717 RKSQPPALLQPGTRNTQPHLLQASSNAKNNTGCLPSMTGEQTAKRASHKG----RPRLGSCRTEATPFQVPVAAPR--GL 790
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsRPRRARRLGRAAQASSPPQRPRrrAA 2688

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  791 RPKPKTVSELLR---EKRLRESHAKKATQALGLNSQLLVSSPVILQPPLLPVPHGSPVvGPATSSVElSVPVAPVMVSSS 867
Cdd:PHA03247 2689 RPTVGSLTSLADpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA-GPATPGGP-ARPARPPTTAGP 2766

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  868 PSGSWPVGGISAtdkqPPNLQTIslnPPHKGTQVAAPAAFRSLALAPGQVPTGGHLSTLGQTSTTSQkqSLPKVLPILRA 947
Cdd:PHA03247 2767 PAPAPPAAPAAG----PPRRLTR---PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG--PLPPPTSAQPT 2837

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  948 APSLTQLSVQPPVS-------GQPLATK--SSLPVNWVLTTQKllsvqvPAVVGLPQSVMTPETIGLQAKQLPSPAKTPA 1018
Cdd:PHA03247 2838 APPPPPGPPPPSLPlggsvapGGDVRRRppSRSPAAKPAAPAR------PPVRRLARPAVSRSTESFALPPDQPERPPQP 2911

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755497391 1019 FLEQPPASTDTEPKGPQGQEIPPTPGPEKAAL----DLSLLSQESEAAIVTWLkgcqGAFVP 1076
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLapttDPAGAGEPSGAVPQPWL----GALVP 2969
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 259-322 4.12e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 48.08  E-value: 4.12e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755497391   259 WTEEEDHMLTQLVQEMrvGNHipYRKIVYFMEGRDSMQLIYRWTKSLDPSLKRGFWAPEEDAKL 322
Cdd:pfam13921    1 WTEEEDEKLLKLVEKY--GND--WKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
REB1 super family cl34920
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 102-309 2.53e-04

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5147:

Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 45.16  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  102 LRKSVVSDRLQRLLQP-KLLKLEYLHEKQSRVSSELERQALEKQIKEAEKEI---------QDINQLPE-----EALLGN 166
Cdd:COG5147   170 VPRVSKADVKPREKGEeNNPDIEDLQEMKELKSASITRHLILPSKSEINKAFkkgetlaleQEINEYKEkkglsRKQFCE 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  167 RLDSHDWEKISNINFE----GARSAEEIRKFWQSSEHPSISKQEWSTEEVERLKAIAATHGHLeWHLVAEELGTSRSafQ 242
Cdd:COG5147   250 RIWSTDRDEDKFWPNIykklPYRDKKSIYKHLRRKYNIFEQRGKWTKEEEQELAKLVVEHGGS-WTEIGKLLGRMPN--D 326

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755497391  243 CLQKFQQYNK---TLKRKEWTEEEDHMLTQLVQEMRVGNHiPYRKIVYF---MEGRDSMQLIYRWTKSLDPSL 309
Cdd:COG5147   327 CRDRWRDYVKcgdTLKRNRWSIEEEELLDKVVNEMRLEAQ-QSSRILWLliaQNIRNRLQHHCRDKYGVLISN 398
 
Name Accession Description Interval E-value
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 314-374 3.37e-14

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 68.11  E-value: 3.37e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755497391   314 WAPEEDAKLLQAVAKYGaQDWFKIREEVPGRSDAQCRDRYIRRLHFSLKKGRWNAKEEQQL 374
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
363-406 1.38e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 66.09  E-value: 1.38e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 755497391    363 KGRWNAKEEQQLIQLIEKYGVGHWARIASELPHRSGSQCLSKWK 406
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWR 44
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 314-357 2.34e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 65.29  E-value: 2.34e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755497391  314 WAPEEDAKLLQAVAKYGAQDWFKIREEVPGRSDAQCRDRYIRRL 357
Cdd:cd00167     2 WTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
311-358 3.51e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 64.94  E-value: 3.51e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 755497391    311 RGFWAPEEDAKLLQAVAKYGAQDWFKIREEVPGRSDAQCRDRYIRRLH 358
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLK 48
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 365-406 4.09e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 64.52  E-value: 4.09e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755497391  365 RWNAKEEQQLIQLIEKYGVGHWARIASELPHRSGSQCLSKWK 406
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWR 42
PLN03091 PLN03091
hypothetical protein; Provisional
 309-423 1.24e-12

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 71.55  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  309 LKRGFWAPEEDAKLLQAVAKYGAQDWfkirEEVPGRSDAQ-----CRDRYIRRLHFSLKKGRWNAKEEQQLIQLIEKYGv 383
Cdd:PLN03091   12 LRKGLWSPEEDEKLLRHITKYGHGCW----SSVPKQAGLQrcgksCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLG- 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 755497391  384 GHWARIASELPHRSGSQCLSKWKILARKKqhlQRKRGQRP 423
Cdd:PLN03091   87 NRWSQIAAQLPGRTDNEIKNLWNSCLKKK---LRQRGIDP 123
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 363-405 1.27e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 57.51  E-value: 1.27e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 755497391   363 KGRWNAKEEQQLIQLIEKYGvGHWARIASELPHRSGSQCLSKW 405
Cdd:pfam00249    1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRW 42
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 309-405 4.33e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 57.49  E-value: 4.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  309 LKRGFWAPEEDAKLLQAVAKYGAQDWFKIREEVPGRSDAQCRDRYIRRLHFSLKKGRWNAKEEQQLIQLIEKYGVgHWAR 388
Cdd:COG5147    18 RKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGT-QWST 96

                          90
                  ....*....|....*..
gi 755497391  389 IASELPHRSGSQCLSKW 405
Cdd:COG5147    97 IADYKDRRTAQQCVERY 113
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
204-253 9.42e-08

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 49.53  E-value: 9.42e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 755497391    204 KQEWSTEEVERLKAIAATHGHLEWHLVAEELGTsRSAFQCLQKFQQYNKT 253
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPG-RTAEQCRERWRNLLKP 49
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 207-267 3.16e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 48.46  E-value: 3.16e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755497391   207 WSTEEVERLKAIAATHGhLEWHLVAEELGtSRSAFQCLQKFQQY-NKTLKRKEWTEEEDHML 267
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYG-NDWKQIAKELG-RRTPKQCFDRWRRKlNPKISRGPWSKEEDQRL 60
PHA03247 PHA03247
large tegument protein UL36; Provisional
 717-1076 3.50e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 3.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  717 RKSQPPALLQPGTRNTQPHLLQASSNAKNNTGCLPSMTGEQTAKRASHKG----RPRLGSCRTEATPFQVPVAAPR--GL 790
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsRPRRARRLGRAAQASSPPQRPRrrAA 2688

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  791 RPKPKTVSELLR---EKRLRESHAKKATQALGLNSQLLVSSPVILQPPLLPVPHGSPVvGPATSSVElSVPVAPVMVSSS 867
Cdd:PHA03247 2689 RPTVGSLTSLADpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA-GPATPGGP-ARPARPPTTAGP 2766

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  868 PSGSWPVGGISAtdkqPPNLQTIslnPPHKGTQVAAPAAFRSLALAPGQVPTGGHLSTLGQTSTTSQkqSLPKVLPILRA 947
Cdd:PHA03247 2767 PAPAPPAAPAAG----PPRRLTR---PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG--PLPPPTSAQPT 2837

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  948 APSLTQLSVQPPVS-------GQPLATK--SSLPVNWVLTTQKllsvqvPAVVGLPQSVMTPETIGLQAKQLPSPAKTPA 1018
Cdd:PHA03247 2838 APPPPPGPPPPSLPlggsvapGGDVRRRppSRSPAAKPAAPAR------PPVRRLARPAVSRSTESFALPPDQPERPPQP 2911

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755497391 1019 FLEQPPASTDTEPKGPQGQEIPPTPGPEKAAL----DLSLLSQESEAAIVTWLkgcqGAFVP 1076
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLapttDPAGAGEPSGAVPQPWL----GALVP 2969
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 259-322 4.12e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 48.08  E-value: 4.12e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755497391   259 WTEEEDHMLTQLVQEMrvGNHipYRKIVYFMEGRDSMQLIYRWTKSLDPSLKRGFWAPEEDAKL 322
Cdd:pfam13921    1 WTEEEDEKLLKLVEKY--GND--WKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 206-250 7.34e-07

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 46.80  E-value: 7.34e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 755497391  206 EWSTEEVERLKAIAATHGHLEWHLVAEELGTsRSAFQCLQKFQQY 250
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPG-RTPKQCRERWRNL 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
256-307 1.02e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 46.45  E-value: 1.02e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 755497391    256 RKEWTEEEDHMLTQLVQEMRVGNhipYRKIVYFMEGRDSMQLIYRWTKSLDP 307
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNN---WEKIAKELPGRTAEQCRERWRNLLKP 49
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 655-1065 5.67e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 50.34  E-value: 5.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   655 PWVGDINLACTQAPRRPATvqtkaDSIRMQLECARLASTPVftLLIQLLQIDTAGCMEVVRERKSQPPALLQPGTRN--- 731
Cdd:pfam17823   35 NGAGKQNASGDAVPRADNK-----SSEQ*NFCAATAAPAPV--TLTKGTSAAHLNSTEVTAEHTPHGTDLSEPATREgaa 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   732 ----TQPHLLQASSNAKNNTGCLPSMTGEQTAKRAShkgRPRLGSCRTEATpfqVPVAAPRGLRPKPKTVSELLREKRLR 807
Cdd:pfam17823  108 dgaaSRALAAAASSSPSSAAQSLPAAIAALPSEAFS---APRAAACRANAS---AAPRAAIAAASAPHAASPAPRTAASS 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   808 ESHAKKATQALGLNSQLLVSSPVILQP--PLL--PVPHGSPVVGPATSSVELSVPVAPVMVSSSPSGSWPVGGISATDKQ 883
Cdd:pfam17823  182 TTAASSTTAASSAPTTAASSAPATLTParGIStaATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAG 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   884 --PPNLQTISLNPPHkGTQVAAPAAFRSLALAPGQVPTGGHlSTLGQTSTTSQKQSLPKVLPilRAAPSLTQLSVQPPVS 961
Cdd:pfam17823  262 tvASAAGTINMGDPH-ARRLSPAKHMPSDTMARNPAAPMGA-QAQGPIIQVSTDQPVHNTAG--EPTPSPSNTTLEPNTP 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   962 GQPLATKSSLpvnwVLTTQKLLSVQVPAVVGLPQSVMTPETIGLQAKQLPSP------AKTPAFLEQP-----PASTDTE 1030
Cdd:pfam17823  338 KSVASTNLAV----VTTTKAQAKEPSASPVPVLHTSMIPEVEATSPTTQPSPllptqgAAGPGILLAPeqvatEATAGTA 413

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 755497391  1031 PKGPQGQEippTPGPEKAALDLSLLSQESEAAIVT 1065
Cdd:pfam17823  414 SAGPTPRS---SGDPKTLAMASCQLSTQGQYLVVT 445
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 102-309 2.53e-04

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 45.16  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  102 LRKSVVSDRLQRLLQP-KLLKLEYLHEKQSRVSSELERQALEKQIKEAEKEI---------QDINQLPE-----EALLGN 166
Cdd:COG5147   170 VPRVSKADVKPREKGEeNNPDIEDLQEMKELKSASITRHLILPSKSEINKAFkkgetlaleQEINEYKEkkglsRKQFCE 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  167 RLDSHDWEKISNINFE----GARSAEEIRKFWQSSEHPSISKQEWSTEEVERLKAIAATHGHLeWHLVAEELGTSRSafQ 242
Cdd:COG5147   250 RIWSTDRDEDKFWPNIykklPYRDKKSIYKHLRRKYNIFEQRGKWTKEEEQELAKLVVEHGGS-WTEIGKLLGRMPN--D 326

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755497391  243 CLQKFQQYNK---TLKRKEWTEEEDHMLTQLVQEMRVGNHiPYRKIVYF---MEGRDSMQLIYRWTKSLDPSL 309
Cdd:COG5147   327 CRDRWRDYVKcgdTLKRNRWSIEEEELLDKVVNEMRLEAQ-QSSRILWLliaQNIRNRLQHHCRDKYGVLISN 398
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 254-353 2.92e-04

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 43.91  E-value: 2.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  254 LKRKEWTEEEDHMLTQLVQEMRVGNHIPYRKIVYFMEGRDSMQLiyRWTKSLDPSLKRGFWAPEEDAKLLQAVAKYGAQd 333
Cdd:PLN03212   23 MKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRL--RWMNYLRPSVKRGGITSDEEDLILRLHRLLGNR- 99

                          90       100
                  ....*....|....*....|
gi 755497391  334 WFKIREEVPGRSDAQCRDRY 353
Cdd:PLN03212  100 WSLIAGRIPGRTDNEIKNYW 119
 
Name Accession Description Interval E-value
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 314-374 3.37e-14

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 68.11  E-value: 3.37e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755497391   314 WAPEEDAKLLQAVAKYGaQDWFKIREEVPGRSDAQCRDRYIRRLHFSLKKGRWNAKEEQQL 374
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
363-406 1.38e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 66.09  E-value: 1.38e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 755497391    363 KGRWNAKEEQQLIQLIEKYGVGHWARIASELPHRSGSQCLSKWK 406
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWR 44
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 314-357 2.34e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 65.29  E-value: 2.34e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755497391  314 WAPEEDAKLLQAVAKYGAQDWFKIREEVPGRSDAQCRDRYIRRL 357
Cdd:cd00167     2 WTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
311-358 3.51e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 64.94  E-value: 3.51e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 755497391    311 RGFWAPEEDAKLLQAVAKYGAQDWFKIREEVPGRSDAQCRDRYIRRLH 358
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLK 48
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 365-406 4.09e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 64.52  E-value: 4.09e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755497391  365 RWNAKEEQQLIQLIEKYGVGHWARIASELPHRSGSQCLSKWK 406
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWR 42
PLN03091 PLN03091
hypothetical protein; Provisional
 309-423 1.24e-12

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 71.55  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  309 LKRGFWAPEEDAKLLQAVAKYGAQDWfkirEEVPGRSDAQ-----CRDRYIRRLHFSLKKGRWNAKEEQQLIQLIEKYGv 383
Cdd:PLN03091   12 LRKGLWSPEEDEKLLRHITKYGHGCW----SSVPKQAGLQrcgksCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLG- 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 755497391  384 GHWARIASELPHRSGSQCLSKWKILARKKqhlQRKRGQRP 423
Cdd:PLN03091   87 NRWSQIAAQLPGRTDNEIKNLWNSCLKKK---LRQRGIDP 123
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 311-357 7.51e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 58.28  E-value: 7.51e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 755497391   311 RGFWAPEEDAKLLQAVAKYGAqDWFKIREEVPGRSDAQCRDRYIRRL 357
Cdd:pfam00249    1 RGPWTPEEDELLLEAVEKLGN-RWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 363-405 1.27e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 57.51  E-value: 1.27e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 755497391   363 KGRWNAKEEQQLIQLIEKYGvGHWARIASELPHRSGSQCLSKW 405
Cdd:pfam00249    1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRW 42
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 309-405 4.33e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 57.49  E-value: 4.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  309 LKRGFWAPEEDAKLLQAVAKYGAQDWFKIREEVPGRSDAQCRDRYIRRLHFSLKKGRWNAKEEQQLIQLIEKYGVgHWAR 388
Cdd:COG5147    18 RKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGT-QWST 96

                          90
                  ....*....|....*..
gi 755497391  389 IASELPHRSGSQCLSKW 405
Cdd:COG5147    97 IADYKDRRTAQQCVERY 113
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
204-253 9.42e-08

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 49.53  E-value: 9.42e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 755497391    204 KQEWSTEEVERLKAIAATHGHLEWHLVAEELGTsRSAFQCLQKFQQYNKT 253
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPG-RTAEQCRERWRNLLKP 49
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 207-267 3.16e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 48.46  E-value: 3.16e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755497391   207 WSTEEVERLKAIAATHGhLEWHLVAEELGtSRSAFQCLQKFQQY-NKTLKRKEWTEEEDHML 267
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYG-NDWKQIAKELG-RRTPKQCFDRWRRKlNPKISRGPWSKEEDQRL 60
PHA03247 PHA03247
large tegument protein UL36; Provisional
 717-1076 3.50e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 3.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  717 RKSQPPALLQPGTRNTQPHLLQASSNAKNNTGCLPSMTGEQTAKRASHKG----RPRLGSCRTEATPFQVPVAAPR--GL 790
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsRPRRARRLGRAAQASSPPQRPRrrAA 2688

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  791 RPKPKTVSELLR---EKRLRESHAKKATQALGLNSQLLVSSPVILQPPLLPVPHGSPVvGPATSSVElSVPVAPVMVSSS 867
Cdd:PHA03247 2689 RPTVGSLTSLADpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA-GPATPGGP-ARPARPPTTAGP 2766

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  868 PSGSWPVGGISAtdkqPPNLQTIslnPPHKGTQVAAPAAFRSLALAPGQVPTGGHLSTLGQTSTTSQkqSLPKVLPILRA 947
Cdd:PHA03247 2767 PAPAPPAAPAAG----PPRRLTR---PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG--PLPPPTSAQPT 2837

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  948 APSLTQLSVQPPVS-------GQPLATK--SSLPVNWVLTTQKllsvqvPAVVGLPQSVMTPETIGLQAKQLPSPAKTPA 1018
Cdd:PHA03247 2838 APPPPPGPPPPSLPlggsvapGGDVRRRppSRSPAAKPAAPAR------PPVRRLARPAVSRSTESFALPPDQPERPPQP 2911

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755497391 1019 FLEQPPASTDTEPKGPQGQEIPPTPGPEKAAL----DLSLLSQESEAAIVTWLkgcqGAFVP 1076
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLapttDPAGAGEPSGAVPQPWL----GALVP 2969
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 365-410 3.63e-07

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 47.95  E-value: 3.63e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 755497391  365 RWNAKEEQQLIQLIEKYGVGHWARIASELP---HRSGSQCLSKWKILAR 410
Cdd:cd11660     2 KWTDEEDEALVEGVEKYGVGNWAKILKDYFfvnNRTSVDLKDKWRNLKK 50
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 259-322 4.12e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 48.08  E-value: 4.12e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755497391   259 WTEEEDHMLTQLVQEMrvGNHipYRKIVYFMEGRDSMQLIYRWTKSLDPSLKRGFWAPEEDAKL 322
Cdd:pfam13921    1 WTEEEDEKLLKLVEKY--GND--WKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 206-250 7.34e-07

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 46.80  E-value: 7.34e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 755497391  206 EWSTEEVERLKAIAATHGHLEWHLVAEELGTsRSAFQCLQKFQQY 250
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPG-RTPKQCRERWRNL 44
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 309-412 9.02e-07

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 51.62  E-value: 9.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  309 LKRGFWAPEEDAKLLQAVAKYGAQDWFKIREEVPG-RSDAQCRDRYIRRLHFSLKKGRWNAKEEQQLIQLIEKYGvGHWA 387
Cdd:PLN03212   23 MKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLG-NRWS 101

                          90       100
                  ....*....|....*....|....*
gi 755497391  388 RIASELPHRSGSQCLSKWKILARKK 412
Cdd:PLN03212  102 LIAGRIPGRTDNEIKNYWNTHLRKK 126
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
256-307 1.02e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 46.45  E-value: 1.02e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 755497391    256 RKEWTEEEDHMLTQLVQEMRVGNhipYRKIVYFMEGRDSMQLIYRWTKSLDP 307
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNN---WEKIAKELPGRTAEQCRERWRNLLKP 49
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 244-405 1.11e-06

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 52.87  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  244 LQKFQQYNKTLKRKE--WTEEEDHMLTQLVQEMRVGNhipYRKIVYFMEGRDSMQLIYRWTKSLDPSLKRGFWAPEEDAK 321
Cdd:COG5147     6 NKELQIKLMQTKRKGgsWKRTEDEDLKALVKKLGPNN---WSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  322 LLQAVAKYGAQdWFKIREEVPGRSDAQCRDRYIRRLHFSLKKgRWNAKEEQQLIQLIEKYGVGHwariaSELPHRSGSQC 401
Cdd:COG5147    83 LIDLDKELGTQ-WSTIADYKDRRTAQQCVERYVNTLEDLSST-HDSKLQRRNEFDKIDPFNENS-----ARRPDIYEDEL 155


                  ....
gi 755497391  402 LSKW 405
Cdd:COG5147   156 LERE 159
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 307-357 5.42e-06

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 44.61  E-value: 5.42e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755497391  307 PSLKRGFWAPEEDAKLLQAVAKYGAQdWFKIREEVpGRSDAQCRDRYIRRL 357
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHLAKLLPTQ-WRTIAPIV-GRTAQQCLERYNKLL 49
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 655-1065 5.67e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 50.34  E-value: 5.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   655 PWVGDINLACTQAPRRPATvqtkaDSIRMQLECARLASTPVftLLIQLLQIDTAGCMEVVRERKSQPPALLQPGTRN--- 731
Cdd:pfam17823   35 NGAGKQNASGDAVPRADNK-----SSEQ*NFCAATAAPAPV--TLTKGTSAAHLNSTEVTAEHTPHGTDLSEPATREgaa 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   732 ----TQPHLLQASSNAKNNTGCLPSMTGEQTAKRAShkgRPRLGSCRTEATpfqVPVAAPRGLRPKPKTVSELLREKRLR 807
Cdd:pfam17823  108 dgaaSRALAAAASSSPSSAAQSLPAAIAALPSEAFS---APRAAACRANAS---AAPRAAIAAASAPHAASPAPRTAASS 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   808 ESHAKKATQALGLNSQLLVSSPVILQP--PLL--PVPHGSPVVGPATSSVELSVPVAPVMVSSSPSGSWPVGGISATDKQ 883
Cdd:pfam17823  182 TTAASSTTAASSAPTTAASSAPATLTParGIStaATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAG 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   884 --PPNLQTISLNPPHkGTQVAAPAAFRSLALAPGQVPTGGHlSTLGQTSTTSQKQSLPKVLPilRAAPSLTQLSVQPPVS 961
Cdd:pfam17823  262 tvASAAGTINMGDPH-ARRLSPAKHMPSDTMARNPAAPMGA-QAQGPIIQVSTDQPVHNTAG--EPTPSPSNTTLEPNTP 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   962 GQPLATKSSLpvnwVLTTQKLLSVQVPAVVGLPQSVMTPETIGLQAKQLPSP------AKTPAFLEQP-----PASTDTE 1030
Cdd:pfam17823  338 KSVASTNLAV----VTTTKAQAKEPSASPVPVLHTSMIPEVEATSPTTQPSPllptqgAAGPGILLAPeqvatEATAGTA 413

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 755497391  1031 PKGPQGQEippTPGPEKAALDLSLLSQESEAAIVT 1065
Cdd:pfam17823  414 SAGPTPRS---SGDPKTLAMASCQLSTQGQYLVVT 445
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 166-420 8.70e-06

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 49.79  E-value: 8.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  166 NRLDShDWEKISNINFE------GARSAEEIRKFWQSSEHPSISKQEWSTEEVERLKAIAATHGHLeWHLVAEELGtSRS 239
Cdd:COG5147    29 EDLKA-LVKKLGPNNWSkvasllISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQ-WSTIADYKD-RRT 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  240 AFQClqkFQQYNKTLKR---KEWTEEED-------------HMLTQLVQEMRVGNHIPYRKIVYFMEG-RDSMQLIYR-- 300
Cdd:COG5147   106 AQQC---VERYVNTLEDlssTHDSKLQRrnefdkidpfnenSARRPDIYEDELLEREVNREASYRLRVpRVSKADVKPre 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  301 ----------------------WTKSLD-PSLKRGFWAP---EEDAK---LLQAVAKYGAQDW---------------FK 336
Cdd:COG5147   183 kgeennpdiedlqemkelksasITRHLIlPSKSEINKAFkkgETLALeqeINEYKEKKGLSRKqfceriwstdrdedkFW 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  337 --IREEVPGRSDAQCRDRYIRRLHFSLKKGRWNAKEEQQLIQLIEKYGvGHWARIaSELPHRSGSQCLSKWKILARKKQH 414
Cdd:COG5147   263 pnIYKKLPYRDKKSIYKHLRRKYNIFEQRGKWTKEEEQELAKLVVEHG-GSWTEI-GKLLGRMPNDCRDRWRDYVKCGDT 340


                  ....*.
gi 755497391  415 LQRKRG 420
Cdd:COG5147   341 LKRNRW 346
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 366-406 1.30e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 43.84  E-value: 1.30e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 755497391   366 WNAKEEQQLIQLIEKYGvGHWARIASELPHRSGSQCLSKWK 406
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWR 40
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 204-250 6.89e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 41.34  E-value: 6.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 755497391   204 KQEWSTEEVERLKAIAATHGHlEWHLVAEELGTsRSAFQCLQKFQQY 250
Cdd:pfam00249    1 RGPWTPEEDELLLEAVEKLGN-RWKKIAKLLPG-RTDNQCKNRWQNY 45
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 200-249 8.00e-05

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 41.53  E-value: 8.00e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 755497391  200 PSISKQEWSTEEVERLKAIaATHGHLEWHLVAEELGtsRSAFQCLQKFQQ 249
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHL-AKLLPTQWRTIAPIVG--RTAQQCLERYNK 47
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 102-309 2.53e-04

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 45.16  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  102 LRKSVVSDRLQRLLQP-KLLKLEYLHEKQSRVSSELERQALEKQIKEAEKEI---------QDINQLPE-----EALLGN 166
Cdd:COG5147   170 VPRVSKADVKPREKGEeNNPDIEDLQEMKELKSASITRHLILPSKSEINKAFkkgetlaleQEINEYKEkkglsRKQFCE 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  167 RLDSHDWEKISNINFE----GARSAEEIRKFWQSSEHPSISKQEWSTEEVERLKAIAATHGHLeWHLVAEELGTSRSafQ 242
Cdd:COG5147   250 RIWSTDRDEDKFWPNIykklPYRDKKSIYKHLRRKYNIFEQRGKWTKEEEQELAKLVVEHGGS-WTEIGKLLGRMPN--D 326

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755497391  243 CLQKFQQYNK---TLKRKEWTEEEDHMLTQLVQEMRVGNHiPYRKIVYF---MEGRDSMQLIYRWTKSLDPSL 309
Cdd:COG5147   327 CRDRWRDYVKcgdTLKRNRWSIEEEELLDKVVNEMRLEAQ-QSSRILWLliaQNIRNRLQHHCRDKYGVLISN 398
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 314-353 2.88e-04

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 39.86  E-value: 2.88e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 755497391  314 WAPEEDAKLLQAVAKYGAQDWFKIREE---VPGRSDAQCRDRY 353
Cdd:cd11660     3 WTDEEDEALVEGVEKYGVGNWAKILKDyffVNNRTSVDLKDKW 45
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 254-353 2.92e-04

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 43.91  E-value: 2.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  254 LKRKEWTEEEDHMLTQLVQEMRVGNHIPYRKIVYFMEGRDSMQLiyRWTKSLDPSLKRGFWAPEEDAKLLQAVAKYGAQd 333
Cdd:PLN03212   23 MKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRL--RWMNYLRPSVKRGGITSDEEDLILRLHRLLGNR- 99

                          90       100
                  ....*....|....*....|
gi 755497391  334 WFKIREEVPGRSDAQCRDRY 353
Cdd:PLN03212  100 WSLIAGRIPGRTDNEIKNYW 119
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 814-1045 3.50e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 3.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   814 ATQALGLNSQLLVSSPVILQPPLLPVPHGSPVVGPATSSV--------ELSVPVAPV-MVSSSPSGSWPVGGISA--TDK 882
Cdd:pfam03154  294 PPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQlqsqqpprEQPLPPAPLsMPHIKPPPTTPIPQLPNpqSHK 373

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   883 QPPNLQTISlnPPHKGTQVAAPAAFRSLALAPGQVPTGGHLSTLGQTSTTSQKQSLPKVLPILRAAPSLT---------- 952
Cdd:pfam03154  374 HPPHLSGPS--PFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPppaashppts 451

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   953 ---QLSVQPPVSGQPLATKSSLPVNWVLTTQKLLSvqvPAVVGLPQSVMTPETIGLQAKQLPSPAKTPAFLEQPPASTDT 1029
Cdd:pfam03154  452 glhQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTS---SAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAE 528

                          250
                   ....*....|....*.
gi 755497391  1030 EPKGPQGQEIPPTPGP 1045
Cdd:pfam03154  529 EPESPPPPPRSPSPEP 544
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 250-381 6.44e-03

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 40.54  E-value: 6.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391  250 YNKTLKRKEWTEEEDHMLTQLVQEmrvgnHIPYRKIVYFMEGRDSMQLIYRW--TKSLDPSLKRGFWAPEEDAKLLQAVA 327
Cdd:COG5147   285 YNIFEQRGKWTKEEEQELAKLVVE-----HGGSWTEIGKLLGRMPNDCRDRWrdYVKCGDTLKRNRWSIEEEELLDKVVN 359

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755497391  328 K-------YGAQDWFKIREEVPGRSDAQCRDRYIRRLHFSlkkgrwNAKEEQQLIQLIEKY 381
Cdd:COG5147   360 EmrleaqqSSRILWLLIAQNIRNRLQHHCRDKYGVLISNS------SPFDAGAAIWLIERY 414
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 825-1049 9.67e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 9.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   825 LVSSPVILQPPLLPVPHgsPVVGPATSsvelsvPVAPVMVSSSPSGSWPVGGisatdKQPPNLQTISLNPPHKGTQVAAP 904
Cdd:pfam03154  230 LIQQTPTLHPQRLPSPH--PPLQPMTQ------PPPPSQVSPQPLPQPSLHG-----QMPPMPHSLQTGPSHMQHPVPPQ 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   905 AAFRSLALAPGQVPTGGHLSTLGQTSTTSQ---------------KQSLPKV---LPILRAAPSL-------TQLSVQPP 959
Cdd:pfam03154  297 PFPLTPQSSQSQVPPGPSPAAPGQSQQRIHtppsqsqlqsqqpprEQPLPPAplsMPHIKPPPTTpipqlpnPQSHKHPP 376

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755497391   960 -VSG-QPLATKSSLPVNWVLTTQKLLSVQVPAVVGLPQSVMTPetiglQAKQLPSPaktPAfleQPPASTDTEPKGPQGQ 1037
Cdd:pfam03154  377 hLSGpSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMP-----QSQQLPPP---PA---QPPVLTQSQSLPPPAA 445

                          250
                   ....*....|..
gi 755497391  1038 EIPPTPGPEKAA 1049
Cdd:pfam03154  446 SHPPTSGLHQVP 457
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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