NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|755497429|ref|XP_011237378|]
View 

ubiquinone biosynthesis protein COQ4 homolog, mitochondrial isoform X2 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Coq4 super family cl47909
Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Coq4p was shown to peripherally associate ...
 63-126 1.22e-32

Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Coq4p was shown to peripherally associate with the matrix face of the mitochondrial inner membrane. The putative mitochondrial- targeting sequence present at the amino-terminus of the polypeptide efficiently imported it to mitochondria. The function of Coq4p is unknown, although its presence is required to maintain a steady-state level of Coq7p, another component of the Q biosynthetic pathway. The overall structure of Coq4 is alpha helical and shows resemblance to haemoglobin/myoglobin (information from TOPSAN).


The actual alignment was detected with superfamily member pfam05019:

Pssm-ID: 461522  Cd Length: 213  Bit Score: 114.12  E-value: 1.22e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755497429   63 YNPYRHDMVAVLGETTGCHTLKFLRDQMKKDPEGAQILQERPRISLSTLDLSKLQSLPEGSLGH 126
Cdd:pfam05019  17 LDPERGDMIAALGETTGGPALERLRDQMLSDPTGRRILRERPRITSETLDLEKLRALPENTFGR 80
 
Name Accession Description Interval E-value
Coq4 pfam05019
Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Coq4p was shown to peripherally associate ...
 63-126 1.22e-32

Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Coq4p was shown to peripherally associate with the matrix face of the mitochondrial inner membrane. The putative mitochondrial- targeting sequence present at the amino-terminus of the polypeptide efficiently imported it to mitochondria. The function of Coq4p is unknown, although its presence is required to maintain a steady-state level of Coq7p, another component of the Q biosynthetic pathway. The overall structure of Coq4 is alpha helical and shows resemblance to haemoglobin/myoglobin (information from TOPSAN).


Pssm-ID: 461522  Cd Length: 213  Bit Score: 114.12  E-value: 1.22e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755497429   63 YNPYRHDMVAVLGETTGCHTLKFLRDQMKKDPEGAQILQERPRISLSTLDLSKLQSLPEGSLGH 126
Cdd:pfam05019  17 LDPERGDMIAALGETTGGPALERLRDQMLSDPTGRRILRERPRITSETLDLEKLRALPENTFGR 80
COQ4 COG5031
Ubiquinone biosynthesis protein Coq4 [Coenzyme transport and metabolism]; Ubiquinone ...
 86-126 5.24e-09

Ubiquinone biosynthesis protein Coq4 [Coenzyme transport and metabolism]; Ubiquinone biosynthesis protein Coq4 is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 444046 [Multi-domain]  Cd Length: 232  Bit Score: 52.24  E-value: 5.24e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 755497429  86 LRDQMKKDPEGAQILQERPRisLSTLDLSKLQSLPEGSLGH 126
Cdd:COG5031   50 LVERLRRSPEGARLLRERPS--LPEIDLEALRKLPEGTLGR 88
 
Name Accession Description Interval E-value
Coq4 pfam05019
Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Coq4p was shown to peripherally associate ...
 63-126 1.22e-32

Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Coq4p was shown to peripherally associate with the matrix face of the mitochondrial inner membrane. The putative mitochondrial- targeting sequence present at the amino-terminus of the polypeptide efficiently imported it to mitochondria. The function of Coq4p is unknown, although its presence is required to maintain a steady-state level of Coq7p, another component of the Q biosynthetic pathway. The overall structure of Coq4 is alpha helical and shows resemblance to haemoglobin/myoglobin (information from TOPSAN).


Pssm-ID: 461522  Cd Length: 213  Bit Score: 114.12  E-value: 1.22e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755497429   63 YNPYRHDMVAVLGETTGCHTLKFLRDQMKKDPEGAQILQERPRISLSTLDLSKLQSLPEGSLGH 126
Cdd:pfam05019  17 LDPERGDMIAALGETTGGPALERLRDQMLSDPTGRRILRERPRITSETLDLEKLRALPENTFGR 80
COQ4 COG5031
Ubiquinone biosynthesis protein Coq4 [Coenzyme transport and metabolism]; Ubiquinone ...
 86-126 5.24e-09

Ubiquinone biosynthesis protein Coq4 [Coenzyme transport and metabolism]; Ubiquinone biosynthesis protein Coq4 is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 444046 [Multi-domain]  Cd Length: 232  Bit Score: 52.24  E-value: 5.24e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 755497429  86 LRDQMKKDPEGAQILQERPRisLSTLDLSKLQSLPEGSLGH 126
Cdd:COG5031   50 LVERLRRSPEGARLLRERPS--LPEIDLEALRKLPEGTLGR 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH