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Conserved domains on  [gi|1039730068|ref|XP_011246390|]
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ly6/PLAUR domain-containing protein 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_LYPD1 cd23559
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 1 (LYPD1) and similar ...
 147-232 1.34e-46

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 1 (LYPD1) and similar proteins; LYPD1 (also called putative HeLa tumor suppressor (PHTS)) may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro LYPD1 increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. It may play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. It may be involved in the control of anxiety. LYPD1 also functions as a novel putative tumor suppressor involved in the transformation reversion of HeLaHF cells independently of the p53 pathway. LYPD1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467089  Cd Length: 85  Bit Score: 150.45  E-value: 1.34e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039730068 147 QIQCYQCEEFQLNNDCSSPEFIVNCTVnVQDMCQKEVMEQSAGIMYRKSCASSAACLIASAGYQSFCSPGKLNSVCISCC 226
Cdd:cd23559     1 QIQCYQCETFQLNDDCSSPEFIVNCTS-VQDMCQKEVMNHSAGIMYRKSCAQSAACLIASAGYQSFCTPGKVGSVCISCC 79


                  ....*.
gi 1039730068 227 NTPLCN 232
Cdd:cd23559    80 NTPLCN 85
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYPD1 cd23559
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 1 (LYPD1) and similar ...
 147-232 1.34e-46

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 1 (LYPD1) and similar proteins; LYPD1 (also called putative HeLa tumor suppressor (PHTS)) may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro LYPD1 increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. It may play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. It may be involved in the control of anxiety. LYPD1 also functions as a novel putative tumor suppressor involved in the transformation reversion of HeLaHF cells independently of the p53 pathway. LYPD1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467089  Cd Length: 85  Bit Score: 150.45  E-value: 1.34e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039730068 147 QIQCYQCEEFQLNNDCSSPEFIVNCTVnVQDMCQKEVMEQSAGIMYRKSCASSAACLIASAGYQSFCSPGKLNSVCISCC 226
Cdd:cd23559     1 QIQCYQCETFQLNDDCSSPEFIVNCTS-VQDMCQKEVMNHSAGIMYRKSCAQSAACLIASAGYQSFCTPGKVGSVCISCC 79


                  ....*.
gi 1039730068 227 NTPLCN 232
Cdd:cd23559    80 NTPLCN 85
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 149-236 3.67e-04

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 38.67  E-value: 3.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039730068  149 QCYQCEEfQLNNDCSSPEfivNCTVNvQDMCQK---EVMEQSAGIMYRKSCASSAACLiASAGYQSFcspGKLNSVCISC 225
Cdd:smart00134   2 QCYSCTG-NPDSSCSSEE---ECRSP-DDVCLTvvaEVISDSRGSVVYKGCATSPICP-GSHGYEIN---LTIAFLKVSC 72

                           90
                   ....*....|.
gi 1039730068  226 CNTPLCNGPRP 236
Cdd:smart00134  73 CQTDLCNAAGP 83
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYPD1 cd23559
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 1 (LYPD1) and similar ...
 147-232 1.34e-46

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 1 (LYPD1) and similar proteins; LYPD1 (also called putative HeLa tumor suppressor (PHTS)) may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro LYPD1 increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. It may play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. It may be involved in the control of anxiety. LYPD1 also functions as a novel putative tumor suppressor involved in the transformation reversion of HeLaHF cells independently of the p53 pathway. LYPD1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467089  Cd Length: 85  Bit Score: 150.45  E-value: 1.34e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039730068 147 QIQCYQCEEFQLNNDCSSPEFIVNCTVnVQDMCQKEVMEQSAGIMYRKSCASSAACLIASAGYQSFCSPGKLNSVCISCC 226
Cdd:cd23559     1 QIQCYQCETFQLNDDCSSPEFIVNCTS-VQDMCQKEVMNHSAGIMYRKSCAQSAACLIASAGYQSFCTPGKVGSVCISCC 79


                  ....*.
gi 1039730068 227 NTPLCN 232
Cdd:cd23559    80 NTPLCN 85
TFP_LU_ECD_CinHb4_like cd23539
extracellular domain (ECD) found in Ciona intestinalis globin CinHb4 and similar proteins; ...
 148-232 1.88e-09

extracellular domain (ECD) found in Ciona intestinalis globin CinHb4 and similar proteins; Four distinct globin genes have been identified in the Ciona genome. CinHb4 is encoded by the fourth globin gene. It shows an unusual extension at its N-terminus, which reveals a conserved region with similarity to the extracellular domain (ECD) of the TGF-beta receptor type I/II protein family involved in signal transduction. The functional relevance of these matches is currently unknown. The ECD belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467069  Cd Length: 91  Bit Score: 53.58  E-value: 1.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039730068 148 IQCYQCEEFQLNNDCSSPEFIVNCTVNvQDMCQKEVMEQSAGIMY-RKSCASSAACL------IASAGYQSFCSPGKLNS 220
Cdd:cd23539     1 LSCWTCDNASSNEECLANGTLVTCQSN-EESCQTEVRRRGGGVYLiSKGCKQRQACEnnkkqnFKAAWNPTQCNPESPNS 79

                          90
                  ....*....|..
gi 1039730068 221 VCISCCNTPLCN 232
Cdd:cd23539    80 VCRCCCSTDLCN 91
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 148-232 7.60e-09

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 51.72  E-value: 7.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039730068 148 IQCYQCEEFQLNNDCSSPEFIVNCTVNvQDMCQKEVMEQSAG-IMYRKSCASSAACLIASagyqSFCSPGKLNSVCISCC 226
Cdd:cd00117     1 LKCYQCNSSNDPNCCNSSPTLVTCSSP-ETFCRKIVGKVGGGeTLVIRGCATECECGCTE----CCSGTGTSGTTCTSCC 75


                  ....*.
gi 1039730068 227 NTPLCN 232
Cdd:cd00117    76 DTDLCN 81
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 148-232 1.18e-04

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 40.07  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039730068 148 IQCYQCEEfQLNNDCSSPE-FIVNCTvNVQDMCQKEVMEQSAGIMYR----KSCASSAACLIASAGyqsfcSPGKLNSVC 222
Cdd:cd23558     8 IQCYSCNG-NSTHGCSSEEtSKVRCR-GPQTQCLEATGTTAHGGKNQsymvKGCATPSMCQSTALS-----LNQVLNSAD 80

                          90
                  ....*....|
gi 1039730068 223 ISCCNTPLCN 232
Cdd:cd23558    81 VRCCNGSLCN 90
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 149-236 3.67e-04

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 38.67  E-value: 3.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039730068  149 QCYQCEEfQLNNDCSSPEfivNCTVNvQDMCQK---EVMEQSAGIMYRKSCASSAACLiASAGYQSFcspGKLNSVCISC 225
Cdd:smart00134   2 QCYSCTG-NPDSSCSSEE---ECRSP-DDVCLTvvaEVISDSRGSVVYKGCATSPICP-GSHGYEIN---LTIAFLKVSC 72

                           90
                   ....*....|.
gi 1039730068  226 CNTPLCNGPRP 236
Cdd:smart00134  73 CQTDLCNAAGP 83
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 147-234 1.55e-03

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 36.54  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039730068 147 QIQCYQCEEFQLNNDCSSPEfivNCTVNvQDMCQKEVMEQSAGIM----YRKSCASSaacliasagyqsfCSPGKLN--- 219
Cdd:cd23575     2 SLKCYTCVSAHSNSDCLTET---NCSSS-DTYCKTLVASASGGSGslttITKWCASS-------------CTPSTRTveg 64

                          90
                  ....*....|....*.
gi 1039730068 220 -SVCISCCNTPLCNGP 234
Cdd:cd23575    65 tKVTVSCCQTDLCNVS 80
TFP_LU_ECD_LYPD6 cd23625
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6 (LYPD6) and similar ...
 149-237 5.46e-03

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6 (LYPD6) and similar proteins; LYPD6 acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. It inhibits nicotine-induced Ca(2+) influx through nAChRs. It functions as a positive regulator of Wnt/beta-catenin signaling. LYPD6 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467145  Cd Length: 89  Bit Score: 35.15  E-value: 5.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039730068 149 QCYQCEEFQLNNDCSSPEFIVNCTVNVQDMCQKEVMEQSA-GIMYRKSCASSAACLiaSAGYQSfcSPGKLNSVCISCCN 227
Cdd:cd23625     3 KCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGnSISVTKRCVPLEKCL--STGCRD--SEHEGHKVCTSCCE 78

                          90
                  ....*....|
gi 1039730068 228 TPLCNGPRPK 237
Cdd:cd23625    79 GNICNLPLPR 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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