|
Name |
Accession |
Description |
Interval |
E-value |
| GLTSCR1 |
pfam15249 |
Conserved region of unknown function on GLTSCR protein; This domain family is found in ... |
1042-1143 |
7.21e-48 |
|
Conserved region of unknown function on GLTSCR protein; This domain family is found in eukaryotes, and is typically between 105 and 124 amino acids in length. It is found on glioma tumour suppressor candidate region gene proteins. ** Forced reload
:
Pssm-ID: 464589 [Multi-domain] Cd Length: 102 Bit Score: 165.91 E-value: 7.21e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 1042 HQGSVLHPDYKTAFPSFEDALHRLLPYHVYQGALPSPNDYHKVDEEFETVSTQLLKRTQAMLNKYRLLLLEESRRVSPSA 1121
Cdd:pfam15249 1 DQKAVLNPDYKTPFASLEDAVKRLLPYHVFQEPKPDEEDLEKADEEFESVATELLKRFQKMLNKYRRLLLRESMRESPSA 80
|
90 100
....*....|....*....|..
gi 755519556 1122 EMVMIDRMFIQEEKTTLALDKQ 1143
Cdd:pfam15249 81 EMVMLERLFLEEERRELEELKR 102
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
321-880 |
2.22e-08 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 59.57 E-value: 2.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 321 PSGQPLAVAPGLGTSPLVQAPSVILHRTPTPIQPKPTGvlpsklyqltpKPFPPTGATLtIQGepgtlpqqpkapqnLTF 400
Cdd:PHA03247 2489 PFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVG-----------EPVHPRMLTW-IRG--------------LEE 2542
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 401 MATGKAGQnvvlsgfPAPALQANVfkQPPVTTTGTAPPQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGTPA 480
Cdd:PHA03247 2543 LASDDAGD-------PPPPLPPAA--PPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAP 2613
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 481 -VQLPQSLSALPANVGGQILTAAAPHAGGQLIANPILTNQNLAGPlslGPVLAPHSGAHSAAHILSAAPIQVGQPALFQM 559
Cdd:PHA03247 2614 pSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAP---GRVSRPRRARRLGRAAQASSPPQRPRRRAARP 2690
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 560 PVSLATGSLPTQSQPAPTGPTATTVLQGVTLPPSAVAmlntpDGLVQPSTPAATTGEATPVLAVQPATQVPPAvTTPLPM 639
Cdd:PHA03247 2691 TVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAA-----ARQASPALPAAPAPPAVPAGPATPGGPARPA-RPPTTA 2764
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 640 GLQQPQAQQPPQVPTPQAATQPQATPPQAS-PSLASSPEKIVLGQAPPAATTAILTQDSLQMFLPQIPAAAPLkAPGPAS 718
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESrESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPT-APPPPP 2843
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 719 SPSLPHQAPLGDSPHMPSPHPARPPSRPPSRPHSRPPSQPQSLTCPPSEPTLHPCPPPQGPPTLpgifviQNQLGAPPPA 798
Cdd:PHA03247 2844 GPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPER------PPQPQAPPPP 2917
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 799 STPASTAPGPPQPPLRPPSQPPEGPLPPASHLPPASTPSAVASSSEPSARLP--VPTPPDFQLQFPPSQGPHKSPTPPPA 876
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPgrVAVPRFRVPQPAPSREAPASSTPPLT 2997
|
....
gi 755519556 877 LHMV 880
Cdd:PHA03247 2998 GHSL 3001
|
|
| dnaA super family |
cl42516 |
chromosomal replication initiator protein DnaA; |
1324-1502 |
1.56e-03 |
|
chromosomal replication initiator protein DnaA;
The actual alignment was detected with superfamily member PRK14086:
Pssm-ID: 455861 [Multi-domain] Cd Length: 617 Bit Score: 42.89 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 1324 PPPAVRKPTVPASCPRLPL--RKTYrENMGNPGAAEGAQGRPRGAGSPTPLPTKVDEATSGLIRELAAVEDELYQRVLKG 1401
Cdd:PRK14086 94 EPAPPPPHARRTSEPELPRpgRRPY-EGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEPGAWPRAADDYGWQQQRL 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 1402 GPPPPETPASATSQGPTEPSWEAPVLPPAKRRKSESPDVDQASFSSDSPQDDTltehlqsaidsilnlQQAPGRTPAGPY 1481
Cdd:PRK14086 173 GFPPRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDRPRRDR---------------TDRPEPPPGAGH 237
|
170 180
....*....|....*....|...
gi 755519556 1482 PH--TGPTPGTPTSPAPLHRPDA 1502
Cdd:PRK14086 238 VHrgGPGPPERDDAPVVPIRPSA 260
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| GLTSCR1 |
pfam15249 |
Conserved region of unknown function on GLTSCR protein; This domain family is found in ... |
1042-1143 |
7.21e-48 |
|
Conserved region of unknown function on GLTSCR protein; This domain family is found in eukaryotes, and is typically between 105 and 124 amino acids in length. It is found on glioma tumour suppressor candidate region gene proteins. ** Forced reload
Pssm-ID: 464589 [Multi-domain] Cd Length: 102 Bit Score: 165.91 E-value: 7.21e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 1042 HQGSVLHPDYKTAFPSFEDALHRLLPYHVYQGALPSPNDYHKVDEEFETVSTQLLKRTQAMLNKYRLLLLEESRRVSPSA 1121
Cdd:pfam15249 1 DQKAVLNPDYKTPFASLEDAVKRLLPYHVFQEPKPDEEDLEKADEEFESVATELLKRFQKMLNKYRRLLLRESMRESPSA 80
|
90 100
....*....|....*....|..
gi 755519556 1122 EMVMIDRMFIQEEKTTLALDKQ 1143
Cdd:pfam15249 81 EMVMLERLFLEEERRELEELKR 102
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
321-880 |
2.22e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 59.57 E-value: 2.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 321 PSGQPLAVAPGLGTSPLVQAPSVILHRTPTPIQPKPTGvlpsklyqltpKPFPPTGATLtIQGepgtlpqqpkapqnLTF 400
Cdd:PHA03247 2489 PFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVG-----------EPVHPRMLTW-IRG--------------LEE 2542
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 401 MATGKAGQnvvlsgfPAPALQANVfkQPPVTTTGTAPPQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGTPA 480
Cdd:PHA03247 2543 LASDDAGD-------PPPPLPPAA--PPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAP 2613
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 481 -VQLPQSLSALPANVGGQILTAAAPHAGGQLIANPILTNQNLAGPlslGPVLAPHSGAHSAAHILSAAPIQVGQPALFQM 559
Cdd:PHA03247 2614 pSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAP---GRVSRPRRARRLGRAAQASSPPQRPRRRAARP 2690
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 560 PVSLATGSLPTQSQPAPTGPTATTVLQGVTLPPSAVAmlntpDGLVQPSTPAATTGEATPVLAVQPATQVPPAvTTPLPM 639
Cdd:PHA03247 2691 TVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAA-----ARQASPALPAAPAPPAVPAGPATPGGPARPA-RPPTTA 2764
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 640 GLQQPQAQQPPQVPTPQAATQPQATPPQAS-PSLASSPEKIVLGQAPPAATTAILTQDSLQMFLPQIPAAAPLkAPGPAS 718
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESrESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPT-APPPPP 2843
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 719 SPSLPHQAPLGDSPHMPSPHPARPPSRPPSRPHSRPPSQPQSLTCPPSEPTLHPCPPPQGPPTLpgifviQNQLGAPPPA 798
Cdd:PHA03247 2844 GPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPER------PPQPQAPPPP 2917
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 799 STPASTAPGPPQPPLRPPSQPPEGPLPPASHLPPASTPSAVASSSEPSARLP--VPTPPDFQLQFPPSQGPHKSPTPPPA 876
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPgrVAVPRFRVPQPAPSREAPASSTPPLT 2997
|
....
gi 755519556 877 LHMV 880
Cdd:PHA03247 2998 GHSL 3001
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
286-691 |
5.20e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 44.76 E-value: 5.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 286 GLVIQKNLPAAVTTTLNGNSVFAGTGAATAAASGAPSGQPLAVAPGLGTSPLVQA-PSVILHRTPTPIQPKPTGVLPSKL 364
Cdd:pfam03154 179 GAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQtPTLHPQRLPSPHPPLQPMTQPPPP 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 365 YQLTPKPFPPtgATLTIQGEPGTLP--------QQPKAPQNLTFMATGKAGQnVVLSGFPAPALQANVFKQPPVTTTGTA 436
Cdd:pfam03154 259 SQVSPQPLPQ--PSLHGQMPPMPHSlqtgpshmQHPVPPQPFPLTPQSSQSQ-VPPGPSPAAPGQSQQRIHTPPSQSQLQ 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 437 PPQPPGALSKPMSvhllnqgssiVIPAQHMLPGqnqfllPGTPAVQLPQSLSAlpanvggqiltAAAPHAGGqliANPIL 516
Cdd:pfam03154 336 SQQPPREQPLPPA----------PLSMPHIKPP------PTTPIPQLPNPQSH-----------KHPPHLSG---PSPFQ 385
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 517 TNQNLAGPLSLGPVLAPHSGAHSAAH---ILSAAPIQVGQPALFQMPVSLATGSLPTQSQPAPTGPTATTVLQGVTLPPS 593
Cdd:pfam03154 386 MNSNLPPPPALKPLSSLSTHHPPSAHpppLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQH 465
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 594 AVaMLNTPDGLVQPSTPAATTGEATPvlAVQPATQVPPAVTTPLPMGLQQPQAQQPPQVPTPQAATQPQATPPqasPSLA 673
Cdd:pfam03154 466 PF-VPGGPPPITPPSGPPTSTSSAMP--GIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPP---PPRS 539
|
410
....*....|....*...
gi 755519556 674 SSPEKIVLGQAPPAATTA 691
Cdd:pfam03154 540 PSPEPTVVNTPSHASQSA 557
|
|
| dnaA |
PRK14086 |
chromosomal replication initiator protein DnaA; |
1324-1502 |
1.56e-03 |
|
chromosomal replication initiator protein DnaA;
Pssm-ID: 237605 [Multi-domain] Cd Length: 617 Bit Score: 42.89 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 1324 PPPAVRKPTVPASCPRLPL--RKTYrENMGNPGAAEGAQGRPRGAGSPTPLPTKVDEATSGLIRELAAVEDELYQRVLKG 1401
Cdd:PRK14086 94 EPAPPPPHARRTSEPELPRpgRRPY-EGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEPGAWPRAADDYGWQQQRL 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 1402 GPPPPETPASATSQGPTEPSWEAPVLPPAKRRKSESPDVDQASFSSDSPQDDTltehlqsaidsilnlQQAPGRTPAGPY 1481
Cdd:PRK14086 173 GFPPRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDRPRRDR---------------TDRPEPPPGAGH 237
|
170 180
....*....|....*....|...
gi 755519556 1482 PH--TGPTPGTPTSPAPLHRPDA 1502
Cdd:PRK14086 238 VHrgGPGPPERDDAPVVPIRPSA 260
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| GLTSCR1 |
pfam15249 |
Conserved region of unknown function on GLTSCR protein; This domain family is found in ... |
1042-1143 |
7.21e-48 |
|
Conserved region of unknown function on GLTSCR protein; This domain family is found in eukaryotes, and is typically between 105 and 124 amino acids in length. It is found on glioma tumour suppressor candidate region gene proteins. ** Forced reload
Pssm-ID: 464589 [Multi-domain] Cd Length: 102 Bit Score: 165.91 E-value: 7.21e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 1042 HQGSVLHPDYKTAFPSFEDALHRLLPYHVYQGALPSPNDYHKVDEEFETVSTQLLKRTQAMLNKYRLLLLEESRRVSPSA 1121
Cdd:pfam15249 1 DQKAVLNPDYKTPFASLEDAVKRLLPYHVFQEPKPDEEDLEKADEEFESVATELLKRFQKMLNKYRRLLLRESMRESPSA 80
|
90 100
....*....|....*....|..
gi 755519556 1122 EMVMIDRMFIQEEKTTLALDKQ 1143
Cdd:pfam15249 81 EMVMLERLFLEEERRELEELKR 102
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
321-880 |
2.22e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 59.57 E-value: 2.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 321 PSGQPLAVAPGLGTSPLVQAPSVILHRTPTPIQPKPTGvlpsklyqltpKPFPPTGATLtIQGepgtlpqqpkapqnLTF 400
Cdd:PHA03247 2489 PFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVG-----------EPVHPRMLTW-IRG--------------LEE 2542
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 401 MATGKAGQnvvlsgfPAPALQANVfkQPPVTTTGTAPPQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGTPA 480
Cdd:PHA03247 2543 LASDDAGD-------PPPPLPPAA--PPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAP 2613
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 481 -VQLPQSLSALPANVGGQILTAAAPHAGGQLIANPILTNQNLAGPlslGPVLAPHSGAHSAAHILSAAPIQVGQPALFQM 559
Cdd:PHA03247 2614 pSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAP---GRVSRPRRARRLGRAAQASSPPQRPRRRAARP 2690
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 560 PVSLATGSLPTQSQPAPTGPTATTVLQGVTLPPSAVAmlntpDGLVQPSTPAATTGEATPVLAVQPATQVPPAvTTPLPM 639
Cdd:PHA03247 2691 TVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAA-----ARQASPALPAAPAPPAVPAGPATPGGPARPA-RPPTTA 2764
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 640 GLQQPQAQQPPQVPTPQAATQPQATPPQAS-PSLASSPEKIVLGQAPPAATTAILTQDSLQMFLPQIPAAAPLkAPGPAS 718
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESrESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPT-APPPPP 2843
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 719 SPSLPHQAPLGDSPHMPSPHPARPPSRPPSRPHSRPPSQPQSLTCPPSEPTLHPCPPPQGPPTLpgifviQNQLGAPPPA 798
Cdd:PHA03247 2844 GPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPER------PPQPQAPPPP 2917
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 799 STPASTAPGPPQPPLRPPSQPPEGPLPPASHLPPASTPSAVASSSEPSARLP--VPTPPDFQLQFPPSQGPHKSPTPPPA 876
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPgrVAVPRFRVPQPAPSREAPASSTPPLT 2997
|
....
gi 755519556 877 LHMV 880
Cdd:PHA03247 2998 GHSL 3001
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
661-1029 |
2.64e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.08 E-value: 2.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 661 PQATPPQASPSLASSPEKIVLGQAPPAATTAI-----LTQDSLQMFLPQIPAAAPLKAPGPASSPSLPHQAPLGDS---- 731
Cdd:PHA03247 2506 PDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIrgleeLASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAvtsr 2585
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 732 ---------PHMPSPHPARPPSRPPSRPHSRPPSQPQSLTCPPSEPTLHPCPPPQGPPTLPGIFVIQNQLGAPPPASTPA 802
Cdd:PHA03247 2586 arrpdappqSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR 2665
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 803 STapgPPQPPLRPPSQPPEGPLPPAshLPPASTPSAVASSSEPSARLPVPTPPDFQLQFPPSQGPHKSPTPPPALHMVPE 882
Cdd:PHA03247 2666 RA---RRLGRAAQASSPPQRPRRRA--ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPA 2740
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 883 PTAPPPPPPRTFQMVTAPFPALPQ----------PKALLERFHQVPSGIILQNKAGGTPTTPQTSTTLGTLTGPTASVLV 952
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPTTAgppapappaaPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 953 SGQAPPGTPAASSHVPASTPMATTGLPPLLPAENKAFA----SNLPTLSVAKATVSGPGKPPAIQYDSKLCSLKKQPLLQ 1028
Cdd:PHA03247 2821 AASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL 2900
|
.
gi 755519556 1029 P 1029
Cdd:PHA03247 2901 P 2901
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
286-691 |
5.20e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 44.76 E-value: 5.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 286 GLVIQKNLPAAVTTTLNGNSVFAGTGAATAAASGAPSGQPLAVAPGLGTSPLVQA-PSVILHRTPTPIQPKPTGVLPSKL 364
Cdd:pfam03154 179 GAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQtPTLHPQRLPSPHPPLQPMTQPPPP 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 365 YQLTPKPFPPtgATLTIQGEPGTLP--------QQPKAPQNLTFMATGKAGQnVVLSGFPAPALQANVFKQPPVTTTGTA 436
Cdd:pfam03154 259 SQVSPQPLPQ--PSLHGQMPPMPHSlqtgpshmQHPVPPQPFPLTPQSSQSQ-VPPGPSPAAPGQSQQRIHTPPSQSQLQ 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 437 PPQPPGALSKPMSvhllnqgssiVIPAQHMLPGqnqfllPGTPAVQLPQSLSAlpanvggqiltAAAPHAGGqliANPIL 516
Cdd:pfam03154 336 SQQPPREQPLPPA----------PLSMPHIKPP------PTTPIPQLPNPQSH-----------KHPPHLSG---PSPFQ 385
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 517 TNQNLAGPLSLGPVLAPHSGAHSAAH---ILSAAPIQVGQPALFQMPVSLATGSLPTQSQPAPTGPTATTVLQGVTLPPS 593
Cdd:pfam03154 386 MNSNLPPPPALKPLSSLSTHHPPSAHpppLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQH 465
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 594 AVaMLNTPDGLVQPSTPAATTGEATPvlAVQPATQVPPAVTTPLPMGLQQPQAQQPPQVPTPQAATQPQATPPqasPSLA 673
Cdd:pfam03154 466 PF-VPGGPPPITPPSGPPTSTSSAMP--GIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPP---PPRS 539
|
410
....*....|....*...
gi 755519556 674 SSPEKIVLGQAPPAATTA 691
Cdd:pfam03154 540 PSPEPTVVNTPSHASQSA 557
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
535-723 |
7.55e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 44.10 E-value: 7.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 535 SGAHSAAHILSAAPIQVGQPALFQMPVSLATGSLPTQSQPAPTGPTATTVLQGVTLPPSAVAMLNTPDGLVQPSTPAATT 614
Cdd:PRK12323 368 SGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGA 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 615 GEATPVLAVQPATQVPPAVTTPLPMGlQQPQAQQPPQVPTPQAATQPQATPP-QASPSLASSPEKIVLGQAPPAATTAIL 693
Cdd:PRK12323 448 PAPAPAPAAAPAAAARPAAAGPRPVA-AAAAAAPARAAPAAAPAPADDDPPPwEELPPEFASPAPAQPDAAPAGWVAESI 526
|
170 180 190
....*....|....*....|....*....|
gi 755519556 694 TQDSLQMFLPQIPAAAPLKAPGPASSPSLP 723
Cdd:PRK12323 527 PDPATADPDDAFETLAPAPAAAPAPRAAAA 556
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
539-876 |
8.23e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 44.39 E-value: 8.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 539 SAAHILSAAPIQVGQPALFQMPVSLATGSLPTQSQPAPTGPTATTVLQGVTLPPSAVAMLNTPDGLVQPSTPAATTGEAT 618
Cdd:PHA03307 46 DSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPAS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 619 PvlavqpATQVPPAVTTPLPMGLQQPQAQQPPQVPTPQAATQPQATPpqaspslASSPEKIVLGQAPPAATTAIltqdsl 698
Cdd:PHA03307 126 P------PPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDA-------ASSRQAALPLSSPEETARAP------ 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 699 qmflPQIPAAAPLKAPGPASSPSLPHQAPLGDSPHMPSPHPARPPSRPPSRPHSRPPSQPQSLTCPPSEPTLHPCPPPQG 778
Cdd:PHA03307 187 ----SSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAP 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 779 PPTLPGIFVIQNQLGAPPPASTPASTAPGPPQPPLRPPSQPPEGPLPPASHLPPASTPSAVASSSEPSARLPVPTPPDFQ 858
Cdd:PHA03307 263 ITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVS 342
|
330
....*....|....*...
gi 755519556 859 LQFPPSQGPHKSPTPPPA 876
Cdd:PHA03307 343 PGPSPSRSPSPSRPPPPA 360
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
569-730 |
1.06e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 43.55 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 569 PTQSQPAPTGPTATTVLQGVTLPPSAVAmlntpdglvqPSTPAATTGEATPVLAVQPATQVPPAVTTPLPMGLQQPQAQQ 648
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARPEAAAPAAAP----------VAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPA 435
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 649 PPQVPTPQAATQPQATPPQASPSLASSPEKIvlgQAPPAAttailtqdslqmflpqiPAAAPLKAPGPASSPSLPhqAPL 728
Cdd:PRK14951 436 AAPAAAPAAVALAPAPPAQAAPETVAIPVRV---APEPAV-----------------ASAAPAPAAAPAAARLTP--TEE 493
|
..
gi 755519556 729 GD 730
Cdd:PRK14951 494 GD 495
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
323-726 |
1.09e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.60 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 323 GQPLAVAPGLGTSPLVQAPSVILHRTPTPIQPKPTGVLPsklyqltPKPFPPTgatltiqGEPGTLPQQPKAPQNLTFMA 402
Cdd:pfam03154 169 TQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVP-------PQGSPAT-------SQPPNQTQSTAAPHTLIQQT 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 403 TGKAGQNVvlsGFPAPALQANVFKQPPVTTTGTAPPQPPGALSKPMSVHLLNQGSSIVipaQHMLPGQNQFLLPGTPAVQ 482
Cdd:pfam03154 235 PTLHPQRL---PSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHM---QHPVPPQPFPLTPQSSQSQ 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 483 LPQSLSALPANVGGQILTAAAPHAGGQLIANPiltnqnLAGPLSLGPVLAPHSGAHSAAHILSAA-------PIQVGQPA 555
Cdd:pfam03154 309 VPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPP------REQPLPPAPLSMPHIKPPPTTPIPQLPnpqshkhPPHLSGPS 382
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 556 LFQMPVSLAT-------GSLPTQSQPAPTGPTATTVLQGVTLPPSAVamlnTPDGLVQPSTPAATTGEATPVLAVQPATQ 628
Cdd:pfam03154 383 PFQMNSNLPPppalkplSSLSTHHPPSAHPPPLQLMPQSQQLPPPPA----QPPVLTQSQSLPPPAASHPPTSGLHQVPS 458
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 629 VPPAVTTPLPMGLQQPQAQQPPQVPTPQAATQPQATPPQASPSLASSPEKIVLGQAPPAATTAILTQDSLQMFLPQIPAA 708
Cdd:pfam03154 459 QSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPR 538
|
410
....*....|....*...
gi 755519556 709 APLKAPGPASSPSLPHQA 726
Cdd:pfam03154 539 SPSPEPTVVNTPSHASQS 556
|
|
| dnaA |
PRK14086 |
chromosomal replication initiator protein DnaA; |
1324-1502 |
1.56e-03 |
|
chromosomal replication initiator protein DnaA;
Pssm-ID: 237605 [Multi-domain] Cd Length: 617 Bit Score: 42.89 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 1324 PPPAVRKPTVPASCPRLPL--RKTYrENMGNPGAAEGAQGRPRGAGSPTPLPTKVDEATSGLIRELAAVEDELYQRVLKG 1401
Cdd:PRK14086 94 EPAPPPPHARRTSEPELPRpgRRPY-EGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEPGAWPRAADDYGWQQQRL 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 1402 GPPPPETPASATSQGPTEPSWEAPVLPPAKRRKSESPDVDQASFSSDSPQDDTltehlqsaidsilnlQQAPGRTPAGPY 1481
Cdd:PRK14086 173 GFPPRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDRPRRDR---------------TDRPEPPPGAGH 237
|
170 180
....*....|....*....|...
gi 755519556 1482 PH--TGPTPGTPTSPAPLHRPDA 1502
Cdd:PRK14086 238 VHrgGPGPPERDDAPVVPIRPSA 260
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1280-1505 |
3.07e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.62 E-value: 3.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 1280 TALDPVHQPLPAPTPAKGAEPPPHPAPPPLPPATQAQMNGTLDHPPPAVRKPTVPASCPRLPLRKTYRENMGNPGAAEGA 1359
Cdd:PHA03247 2735 LPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAP 2814
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 1360 QGRPRGAGSPT---PLPTKVDEATSGLIRELAAVEDELYQRVLKGGP----PPPETPAS--ATSQGPTEPSWEAPVLPPA 1430
Cdd:PHA03247 2815 AAALPPAASPAgplPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrrrPPSRSPAAkpAAPARPPVRRLARPAVSRS 2894
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755519556 1431 KRRKSESPDVDQASFSSDSPQDDTLTEHLQSAIDSILNLQQaPGRTPAGPYPHTGPTP-GTPTSPAPLHRPDAFPP 1505
Cdd:PHA03247 2895 TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP-PPRPQPPLAPTTDPAGaGEPSGAVPQPWLGALVP 2969
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
335-727 |
3.51e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 41.98 E-value: 3.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 335 SPLVQAPSVILHRTPTPIQPKPTGVlPSKLYQLTP-KPFP-PTGATLTIQGEPGTLPQQPKAPQNLTFMATGKAGQNVVL 412
Cdd:PHA03378 444 TPHSQAPTVVLHRPPTQPLEGPTGP-LSVQAPLEPwQPLPhPQVTPVILHQPPAQGVQAHGSMLDLLEKDDEDMEQRVMA 522
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 413 SGFPApalqanvfkqppvtttgtAPPQPPGALSKPmSVHLLNQGSSIVIPAQHMLPGQNQFLLPGTPAVQLPQSLSALPA 492
Cdd:PHA03378 523 TLLPP------------------SPPQPRAGRRAP-CVYTEDLDIESDEPASTEPVHDQLLPAPGLGPLQIQPLTSPTTS 583
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 493 nvggQILTAAAPHAGgqlIANPILTNQNLAGPLSLGPVLAPHSGAHSAAHILSAAPIQV--GQPALFQMPVsLATGSLPT 570
Cdd:PHA03378 584 ----QLASSAPSYAQ---TPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPlrMQPITFNVLV-FPTPHQPP 655
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 571 QSQPAPTGPTATTV----LQGVTLPPSAVAMLNTPDGLVQPstPAATTGEATPVLAVQPATQVPPAVTTPLPmglqqpQA 646
Cdd:PHA03378 656 QVEITPYKPTWTQIghipYQPSPTGANTMLPIQWAPGTMQP--PPRAPTPMRPPAAPPGRAQRPAAATGRAR------PP 727
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519556 647 QQPPQVPTPQAATQPQATPPQASPSLASSPEKIVLGQAPPAATTAILTqdslQMFLPQIPaAAPLKAPGPASSPSLPHQA 726
Cdd:PHA03378 728 AAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPT----PQPPPQAP-PAPQQRPRGAPTPQPPPQA 802
|
.
gi 755519556 727 P 727
Cdd:PHA03378 803 G 803
|
|
| |
