F-box only protein 47 isoform X3 [Homo sapiens]
Protein Classification
F-box only protein 47( domain architecture ID 17778469)
F-box only protein 47 functions as the substrate-recognition component of an SCF (Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| F-box_FBXO47 | cd22112 | F-box domain found in F-box only protein 47 (FBXO47) and similar proteins; FBXO47, also called ... |
44-82 | 2.75e-13 | ||
F-box domain found in F-box only protein 47 (FBXO47) and similar proteins; FBXO47, also called FBX47, functions as the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It has a potential role as a tumor-suppressor gene. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. : Pssm-ID: 438884 Cd Length: 39 Bit Score: 63.33 E-value: 2.75e-13
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| Name | Accession | Description | Interval | E-value | ||
| F-box_FBXO47 | cd22112 | F-box domain found in F-box only protein 47 (FBXO47) and similar proteins; FBXO47, also called ... |
44-82 | 2.75e-13 | ||
F-box domain found in F-box only protein 47 (FBXO47) and similar proteins; FBXO47, also called FBX47, functions as the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It has a potential role as a tumor-suppressor gene. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438884 Cd Length: 39 Bit Score: 63.33 E-value: 2.75e-13
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| Name | Accession | Description | Interval | E-value | ||
| F-box_FBXO47 | cd22112 | F-box domain found in F-box only protein 47 (FBXO47) and similar proteins; FBXO47, also called ... |
44-82 | 2.75e-13 | ||
F-box domain found in F-box only protein 47 (FBXO47) and similar proteins; FBXO47, also called FBX47, functions as the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It has a potential role as a tumor-suppressor gene. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438884 Cd Length: 39 Bit Score: 63.33 E-value: 2.75e-13
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| F-box_FBXO28 | cd22100 | F-box domain found in F-box only protein 28 (FBXO28) and similar proteins; FBXO28, also called ... |
47-81 | 1.24e-03 | ||
F-box domain found in F-box only protein 28 (FBXO28) and similar proteins; FBXO28, also called FBX28, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It promotes mitotic progression and regulates topoisomerase IIalpha-dependent DNA decatenation. FBXO28 plays a crucial role in the pathogenesis of the 1q41q42 microdeletion syndrome. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438872 Cd Length: 45 Bit Score: 36.37 E-value: 1.24e-03
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| F-box_SF | cd09917 | F-box domain superfamily; This short domain is commonly found at the N-terminus of various ... |
47-73 | 2.27e-03 | ||
F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures. Pssm-ID: 438852 Cd Length: 35 Bit Score: 35.11 E-value: 2.27e-03
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| F-box_FBXL4 | cd22117 | F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ... |
44-77 | 4.13e-03 | ||
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438889 Cd Length: 47 Bit Score: 34.91 E-value: 4.13e-03
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| F-box_ScMDM30-like | cd22143 | F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology ... |
44-82 | 6.74e-03 | ||
F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438915 Cd Length: 44 Bit Score: 34.12 E-value: 6.74e-03
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