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Conserved domains on  [gi|767932611|ref|XP_011530539|]
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protocadherin Fat 4 isoform X1 [Homo sapiens]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 10876624)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 416-511 1.06e-36

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 134.75  E-value: 1.06e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  416 YKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTP 495
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*.
gi 767932611  496 RTDTSTVSIVLLDIND 511
Cdd:cd11304    82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 626-721 6.07e-35

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 129.74  E-value: 6.07e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  626 YFTTIPEDAPTGTDVLLVNASDADASKNAVISYRIIGGNSQ--FTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPe 703
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP- 80

                          90
                  ....*....|....*...
gi 767932611  704 PLSSSTSVLVTVTDVNDN 721
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1667-1765 1.15e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1667 IYSVQISEGVPIGTHVTFVSAFDSDSiPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGT 1746
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 767932611 1747 PSATGSASLLVTLEDINDN 1765
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1352-1449 1.98e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.50  E-value: 1.98e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1352 HMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWV 1431
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 767932611 1432 ARTGYCSVTVNVIDVNDN 1449
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 314-407 2.21e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.50  E-value: 2.21e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  314 TYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLL-NPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLS 392
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                          90
                  ....*....|....*
gi 767932611  393 SSTEVVVMVLDINDN 407
Cdd:cd11304    84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 205-304 1.05e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.50  E-value: 1.05e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  205 SYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVD-KNGVLKVLKALDRESQSFYNLVVQVHDLPQI 283
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90       100
                  ....*....|....*....|.
gi 767932611  284 PasrFTSTAQVSIILLDVNDN 304
Cdd:cd11304    81 P---LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 932-1028 7.94e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 7.94e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  932 PFISEILENLSP-RKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSP 1010
Cdd:cd11304     1 SYEVSVPENAPPgTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 767932611 1011 SQSTSVKVMINILDENDN 1028
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 102-197 2.24e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 111.25  E-value: 2.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  102 VYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGG- 180
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                          90
                  ....*....|....*...
gi 767932611  181 -QFTTIRVYFNILDVNDN 197
Cdd:cd11304    81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 520-617 3.06e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 3.06e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  520 PYSVNVPENL--GTLprtILQVVARDDDRGSNSKLSYVLFGGNEDNAFTL-SASGELGVTQSLDRETKERFVLMITATDS 596
Cdd:cd11304     1 SYEVSVPENAppGTV---VLTVSATDPDSGENGEVTYSIVSGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 767932611  597 GSPALTGTGTINVIVDDVNDN 617
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1035-1127 9.35e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.33  E-value: 9.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1035 IFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIM--DASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG-- 1110
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                          90
                  ....*....|....*...
gi 767932611 1111 -WTVSTDVTIFVTDINDN 1127
Cdd:cd11304    81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 4-94 2.47e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 2.47e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    4 LTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDS-FRIDPESGDLIATRRLDRERRSKYSLLVRADDG---LQS 79
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpPLS 83

                          90
                  ....*....|....*
gi 767932611   80 SDMRINITVSDVNDH 94
Cdd:cd11304    84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1458-1552 4.34e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 4.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1458 YFPTVLENAPSGTTVIHLNATDADSGTNAVIAYT-VQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEE 1536
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*.
gi 767932611 1537 RCSFATVNIQLKGTNE 1552
Cdd:cd11304    82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1773-1869 5.02e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 5.02e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1773 EGEVMENKRPGTLVMTLQSTDPDLPPNqGPFTYYLLStGPATSYFSL-STAGVLSTTREIDREQIADFYLSVVTKDSGVP 1851
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGEN-GEVTYSIVS-GNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 767932611 1852 QMSSTGTVHITVIDQNDN 1869
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1247-1342 2.50e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 2.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1247 YFTPVTKNVKVGTKLIRVTAIDdKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNP 1326
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATD-PDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*.
gi 767932611 1327 PLSSQATVHITVTEEN 1342
Cdd:cd11304    81 PLSSTATVTITVLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1135-1238 3.79e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 3.79e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1135 SYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSE--YFRINATTGEIFNKQILKYQnvtgfsnvNINRHSFIV 1212
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDRE--------EQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 767932611 1213 TSSDRGKPSLISETTVTINIVDSNDN 1238
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1562-1659 2.73e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 2.73e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1562 YYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSir 1641
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-- 79

                          90
                  ....*....|....*...
gi 767932611 1642 GADIDEVTVNVTVLDAND 1659
Cdd:cd11304    80 PPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 830-924 4.61e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 4.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  830 EQTFMFPENQPVSSLVTTITGS---SLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFP 906
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 767932611  907 PFSSYEKLDITVLDVNDN 924
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2236-2399 8.78e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 94.41  E-value: 8.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 2236 SYGFEELSYMEFPSLDP--NNNYIYVKFATIKSHALLLYNYDNQTGDraeFLALEIAEERLRFSYNLGSGTYKLTTMKKV 2313
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAprTRLSISFSFRTTSPNGLLLYAGSQNGGD---FLALELEDGRLVLRYDLGSGSLVLSSKTPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 2314 SDGHFHTVIARRAGMAASLTVDSCSenqepgycTVSNVAVSDDWTLDVQPNrVTVGGirsLEPILQRRGHVESHDFVGCI 2393
Cdd:cd00110    78 NDGQWHSVSVERNGRSVTLSVDGER--------VVESGSPGGSALLNLDGP-LYLGG---LPEDLKSPGLPVSPGFVGCI 145


                  ....*.
gi 767932611 2394 MEFAVN 2399
Cdd:cd00110   146 RDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 729-816 8.60e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 8.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  729 PYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRN-SEKFHIDPLRGAIMAAGPLN--GASEVTFSVHVKDGGSF 805
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|.
gi 767932611  806 PKTDSTTVTVR 816
Cdd:cd11304    81 PLSSTATVTIT 91
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2504-2625 1.47e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 82.08  E-value: 1.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 2504 SLEVKFRTRSENGVLIHI--QESSNYTTVKIKNGKVYFTSDAGIAGKVERniPEVYVADGHWHTFLIGKNGTATVLSVDR 2581
Cdd:cd00110    23 SISFSFRTTSPNGLLLYAgsQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPLNDGQWHSVSVERNGRSVTLSVDG 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 767932611 2582 IYNRDIIHPTQDFGGLDVLTISLGGIPPNQ-AHRDAQTAGFDGCI 2625
Cdd:cd00110   101 ERVVESGSPGGSALLNLDGPLYLGGLPEDLkSPGLPVSPGFVGCI 145
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2121-2157 1.07e-15

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 73.05  E-value: 1.07e-15
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767932611 2121 DIDECL-PSPCHSGGTCHNLVGGFSCSCPDGFTGRACE 2157
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2159-2195 2.28e-13

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 66.51  E-value: 2.28e-13
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767932611 2159 DINECLQ-SPCKNGAICQNFPGSFNCVCKTGYTGKMCE 2195
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2198-2233 3.64e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 3.64e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767932611 2198 VNYCE-CNPCFNGGSCQSGVDSYYCHCPFGVFGKHCE 2233
Cdd:cd00054     2 IDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2688-2722 1.98e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.98e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767932611 2688 DCAS-HPCQNGGSCEPgLHSGFTCSCPDSHTGRTCE 2722
Cdd:cd00054     4 ECASgNPCQNGGTCVN-TVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2425-2455 1.38e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.99  E-value: 1.38e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767932611  2425 CTRSPCQHGGTCMDYWSWQQCHCKEGLTGKY 2455
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 416-511 1.06e-36

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 134.75  E-value: 1.06e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  416 YKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTP 495
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*.
gi 767932611  496 RTDTSTVSIVLLDIND 511
Cdd:cd11304    82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 626-721 6.07e-35

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 129.74  E-value: 6.07e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  626 YFTTIPEDAPTGTDVLLVNASDADASKNAVISYRIIGGNSQ--FTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPe 703
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP- 80

                          90
                  ....*....|....*...
gi 767932611  704 PLSSSTSVLVTVTDVNDN 721
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1667-1765 1.15e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1667 IYSVQISEGVPIGTHVTFVSAFDSDSiPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGT 1746
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 767932611 1747 PSATGSASLLVTLEDINDN 1765
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1352-1449 1.98e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.50  E-value: 1.98e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1352 HMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWV 1431
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 767932611 1432 ARTGYCSVTVNVIDVNDN 1449
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 314-407 2.21e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.50  E-value: 2.21e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  314 TYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLL-NPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLS 392
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                          90
                  ....*....|....*
gi 767932611  393 SSTEVVVMVLDINDN 407
Cdd:cd11304    84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 205-304 1.05e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.50  E-value: 1.05e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  205 SYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVD-KNGVLKVLKALDRESQSFYNLVVQVHDLPQI 283
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90       100
                  ....*....|....*....|.
gi 767932611  284 PasrFTSTAQVSIILLDVNDN 304
Cdd:cd11304    81 P---LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 932-1028 7.94e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 7.94e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  932 PFISEILENLSP-RKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSP 1010
Cdd:cd11304     1 SYEVSVPENAPPgTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 767932611 1011 SQSTSVKVMINILDENDN 1028
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 102-197 2.24e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 111.25  E-value: 2.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  102 VYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGG- 180
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                          90
                  ....*....|....*...
gi 767932611  181 -QFTTIRVYFNILDVNDN 197
Cdd:cd11304    81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 520-617 3.06e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 3.06e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  520 PYSVNVPENL--GTLprtILQVVARDDDRGSNSKLSYVLFGGNEDNAFTL-SASGELGVTQSLDRETKERFVLMITATDS 596
Cdd:cd11304     1 SYEVSVPENAppGTV---VLTVSATDPDSGENGEVTYSIVSGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 767932611  597 GSPALTGTGTINVIVDDVNDN 617
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
416-507 3.12e-28

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 110.47  E-value: 3.12e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   416 YKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTP 495
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 767932611   496 RTDTSTVSIVLL 507
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 435-514 3.45e-28

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 109.75  E-value: 3.45e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    435 AADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVP 514
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1035-1127 9.35e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.33  E-value: 9.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1035 IFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIM--DASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG-- 1110
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                          90
                  ....*....|....*...
gi 767932611 1111 -WTVSTDVTIFVTDINDN 1127
Cdd:cd11304    81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 4-94 2.47e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 2.47e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    4 LTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDS-FRIDPESGDLIATRRLDRERRSKYSLLVRADDG---LQS 79
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpPLS 83

                          90
                  ....*....|....*
gi 767932611   80 SDMRINITVSDVNDH 94
Cdd:cd11304    84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1458-1552 4.34e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 4.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1458 YFPTVLENAPSGTTVIHLNATDADSGTNAVIAYT-VQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEE 1536
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*.
gi 767932611 1537 RCSFATVNIQLKGTNE 1552
Cdd:cd11304    82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1773-1869 5.02e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 5.02e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1773 EGEVMENKRPGTLVMTLQSTDPDLPPNqGPFTYYLLStGPATSYFSL-STAGVLSTTREIDREQIADFYLSVVTKDSGVP 1851
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGEN-GEVTYSIVS-GNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 767932611 1852 QMSSTGTVHITVIDQNDN 1869
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 950-1030 9.49e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 105.89  E-value: 9.49e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    950 SAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNA 1029
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 767932611   1030 P 1030
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1371-1451 1.84e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 105.12  E-value: 1.84e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   1371 SARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNS 1450
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 767932611   1451 P 1451
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 644-723 2.07e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 104.74  E-value: 2.07e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    644 NASDADASKNAVISYRIIGGN--SQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPePLSSSTSVLVTVTDVNDN 721
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDN 79


                    ..
gi 767932611    722 PP 723
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
316-402 2.38e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 102.38  E-value: 2.38e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   316 IPENTPIDTVVFKAQATDPDSGPNSYIEYTLLN-PLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSS 394
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 767932611   395 TEVVVMVL 402
Cdd:pfam00028   85 ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1247-1342 2.50e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 2.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1247 YFTPVTKNVKVGTKLIRVTAIDdKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNP 1326
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATD-PDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*.
gi 767932611 1327 PLSSQATVHITVTEEN 1342
Cdd:cd11304    81 PLSSTATVTITVLDVN 96
Cadherin pfam00028
Cadherin domain;
1668-1760 2.73e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 101.99  E-value: 2.73e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1668 YSVQISEGVPIGTHVTFVSAFDSDSIPSWsRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTP 1747
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNG-RIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 767932611  1748 SATGSASLLVTLE 1760
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 330-409 3.21e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 101.66  E-value: 3.21e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    330 QATDPDSGPNSYIEYTLL-NPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNN 408
Cdd:smart00112    1 SATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 767932611    409 P 409
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1135-1238 3.79e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 3.79e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1135 SYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSE--YFRINATTGEIFNKQILKYQnvtgfsnvNINRHSFIV 1212
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDRE--------EQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 767932611 1213 TSSDRGKPSLISETTVTINIVDSNDN 1238
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1354-1444 4.44e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 101.61  E-value: 4.44e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1354 SATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVAR 1433
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 767932611  1434 TGYCSVTVNVI 1444
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
626-716 1.04e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.45  E-value: 1.04e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   626 YFTTIPEDAPTGTDVLLVNASDADASKNAVISYRIIGGNS--QFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPe 703
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP- 79

                           90
                   ....*....|...
gi 767932611   704 PLSSSTSVLVTVT 716
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1562-1659 2.73e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 2.73e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1562 YYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSir 1641
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-- 79

                          90
                  ....*....|....*...
gi 767932611 1642 GADIDEVTVNVTVLDAND 1659
Cdd:cd11304    80 PPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1686-1767 2.89e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.58  E-value: 2.89e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   1686 SAFDSDSIPSWsRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDN 1765
Cdd:smart00112    1 SATDADSGENG-KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 767932611   1766 GP 1767
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 830-924 4.61e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 4.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  830 EQTFMFPENQPVSSLVTTITGS---SLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFP 906
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 767932611  907 PFSSYEKLDITVLDVNDN 924
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
936-1023 6.64e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.45  E-value: 6.64e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   936 EILENLSP-RKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQST 1014
Cdd:pfam00028    4 SVPENAPVgTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 767932611  1015 SVKVMINIL 1023
Cdd:pfam00028   84 TATVTITVL 92
Cadherin pfam00028
Cadherin domain;
206-299 7.98e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.06  E-value: 7.98e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   206 YSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDK-NGVLKVLKALDRESQSFYNLVVQVHDLPQIP 284
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPdTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....*
gi 767932611   285 ASrftSTAQVSIILL 299
Cdd:pfam00028   81 LS---STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 224-306 1.20e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.95  E-value: 1.20e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    224 NVTDADDGINSQLTYSIASGDSLGQFTVDKN-GVLKVLKALDRESQSFYNLVVQVHDLPQIPASrftSTAQVSIILLDVN 302
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLS---STATVTITVLDVN 77


                    ....
gi 767932611    303 DNPP 306
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 540-619 5.86e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 5.86e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    540 VARDDDRGSNSKLSYVLFGGNEDNAFTL-SASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNV 618
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 767932611    619 P 619
Cdd:smart00112   81 P 81
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2236-2399 8.78e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 94.41  E-value: 8.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 2236 SYGFEELSYMEFPSLDP--NNNYIYVKFATIKSHALLLYNYDNQTGDraeFLALEIAEERLRFSYNLGSGTYKLTTMKKV 2313
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAprTRLSISFSFRTTSPNGLLLYAGSQNGGD---FLALELEDGRLVLRYDLGSGSLVLSSKTPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 2314 SDGHFHTVIARRAGMAASLTVDSCSenqepgycTVSNVAVSDDWTLDVQPNrVTVGGirsLEPILQRRGHVESHDFVGCI 2393
Cdd:cd00110    78 NDGQWHSVSVERNGRSVTLSVDGER--------VVESGSPGGSALLNLDGP-LYLGG---LPEDLKSPGLPVSPGFVGCI 145


                  ....*.
gi 767932611 2394 MEFAVN 2399
Cdd:cd00110   146 RDLKVN 151
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 20-96 2.10e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 2.10e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611     20 TAMDADEGANALVTYTIISGADDS-FRIDPESGDLIATRRLDRERRSKYSLLVRADDG---LQSSDMRINITVSDVNDHT 95
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 767932611     96 P 96
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1773-1864 2.75e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.82  E-value: 2.75e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1773 EGEVMENKRPGTLVMTLQSTDPDLPPNQGPFtyYLLSTGPATSYFSLSTA-GVLSTTREIDREQIADFYLSVVTKDSGVP 1851
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF--YSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 767932611  1852 QMSSTGTVHITVI 1864
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 122-199 4.70e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.72  E-value: 4.70e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    122 ATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQ--FTTIRVYFNILDVNDNPP 199
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
5-88 4.44e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.36  E-value: 4.44e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611     5 TVEENIGDGSKIMQLTAMDADEGANALVTYTIISG-ADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADDGL---QSS 80
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgppLSS 83


                   ....*...
gi 767932611    81 DMRINITV 88
Cdd:pfam00028   84 TATVTITV 91
Cadherin pfam00028
Cadherin domain;
103-192 2.11e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 2.11e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   103 YSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGG--G 180
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|..
gi 767932611   181 QFTTIRVYFNIL 192
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1461-1547 3.46e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 3.46e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1461 TVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSD-LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCS 1539
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*...
gi 767932611  1540 FATVNIQL 1547
Cdd:pfam00028   84 TATVTITV 91
Cadherin pfam00028
Cadherin domain;
521-611 5.26e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.27  E-value: 5.26e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   521 YSVNVPENL--GTlprTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTL-SASGELGVTQSLDRETKERFVLMITATDSG 597
Cdd:pfam00028    1 YSASVPENApvGT---EVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....
gi 767932611   598 SPALTGTGTINVIV 611
Cdd:pfam00028   78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 859-926 7.28e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 7.28e-19
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767932611    859 SYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAP 926
Cdd:smart00112   14 TYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1054-1129 7.64e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 7.64e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   1054 TTSDEDIGINAISRYSIMD--ASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNA 1128
Cdd:smart00112    1 SATDADSGENGKVTYSILSgnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgppLSSTATVTITVLDVNDNA 80


                    .
gi 767932611   1129 P 1129
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1155-1240 1.73e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 1.73e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   1155 ATDPDEGSNGQVFYFIKSQSE--YFRINATTGEIFNKQILKYQNvtgfsnvnINRHSFIVTSSDRGKPSLISETTVTINI 1232
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREE--------QPEYTLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 767932611   1233 VDSNDNAP 1240
Cdd:smart00112   74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1247-1339 4.75e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 4.75e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1247 YFTPVTKNVKVGTKLIRVTAIDdKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNP 1326
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATD-PDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 767932611  1327 PLSSQATVHITVT 1339
Cdd:pfam00028   80 PLSSTATVTITVL 92
LamG smart00282
Laminin G domain;
2256-2401 4.95e-18

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 82.77  E-value: 4.95e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   2256 YIYVKFATIKSHALLLYNYDNQTGDraeFLALEIAEERLRFSYNLGSGTYKLT-TMKKVSDGHFHTVIARRAGMAASLTV 2334
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGD---YLALELRDGRLVLRYDLGSGPARLTsDPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767932611   2335 DSCSEnqepgyctVSNVAVSDDWTLDVqPNRVTVGGirsLEPILQRRGHVESHDFVGCIMEFAVNGR 2401
Cdd:smart00282   78 DGGNR--------VSGESPGGLTILNL-DGPLYLGG---LPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 729-816 8.60e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 8.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  729 PYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRN-SEKFHIDPLRGAIMAAGPLN--GASEVTFSVHVKDGGSF 805
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|.
gi 767932611  806 PKTDSTTVTVR 816
Cdd:cd11304    81 PLSSTATVTIT 91
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2504-2625 1.47e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 82.08  E-value: 1.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 2504 SLEVKFRTRSENGVLIHI--QESSNYTTVKIKNGKVYFTSDAGIAGKVERniPEVYVADGHWHTFLIGKNGTATVLSVDR 2581
Cdd:cd00110    23 SISFSFRTTSPNGLLLYAgsQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPLNDGQWHSVSVERNGRSVTLSVDG 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 767932611 2582 IYNRDIIHPTQDFGGLDVLTISLGGIPPNQ-AHRDAQTAGFDGCI 2625
Cdd:cd00110   101 ERVVESGSPGGSALLNLDGPLYLGGLPEDLkSPGLPVSPGFVGCI 145
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1269-1346 2.89e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 2.89e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767932611   1269 DKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTP 1346
Cdd:smart00112    4 DADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1792-1870 3.19e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 3.19e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   1792 TDPDLPPNqGPFTYYLLStGPATSYFSL-STAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNP 1870
Cdd:smart00112    3 TDADSGEN-GKVTYSILS-GNDDGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1476-1555 4.10e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 4.10e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   1476 NATDADSGTNAVIAYT-VQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYV 1554
Cdd:smart00112    1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 767932611   1555 P 1555
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1036-1122 4.50e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.50  E-value: 4.50e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1036 FSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIM--DASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG--- 1110
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpp 80

                           90
                   ....*....|..
gi 767932611  1111 WTVSTDVTIFVT 1122
Cdd:pfam00028   81 LSSTATVTITVL 92
LamG smart00282
Laminin G domain;
2504-2633 6.10e-17

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 79.69  E-value: 6.10e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   2504 SLEVKFRTRSENGVLIHIQES--SNYTTVKIKNGKVYFTSDAGiAGKVERNIPEVYVADGHWHTFLIGKNGTATVLSVDR 2581
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKggGDYLALELRDGRLVLRYDLG-SGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 767932611   2582 IYNRDIIHPTQDFgGLDVLT-ISLGGIPPNQ-AHRDAQTAGFDGCIASMWYGGE 2633
Cdd:smart00282   80 GNRVSGESPGGLT-ILNLDGpLYLGGLPEDLkLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2509-2633 9.24e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 79.00  E-value: 9.24e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  2509 FRTRSENGVLIHI-QESSNYTTVKIKNGKVYFTSDAGiAGKVERNIPEVYVADGHWHTFLIGKNGTATVLSVDRIYNRDI 2587
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLVLRYDLG-SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 767932611  2588 IHPTQDFGGLDVLTISLGGIPP-NQAHRDAQTAGFDGCIASMWYGGE 2633
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLPPlLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2261-2401 2.61e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 77.85  E-value: 2.61e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  2261 FATIKSHALLLYNydnqTGDRAEFLALEIAEERLRFSYNLGSGTYKLT-TMKKVSDGHFHTVIARRAGMAASLTVDSCSe 2339
Cdd:pfam02210    1 FRTRQPNGLLLYA----GGGGSDFLALELVNGRLVLRYDLGSGPESLLsSGKNLNDGQWHSVRVERNGNTLTLSVDGQT- 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767932611  2340 nqepgycTVSNVAVSDDWTLDVqPNRVTVGGIRSLEPILQRrghVESHDFVGCIMEFAVNGR 2401
Cdd:pfam02210   76 -------VVSSLPPGESLLLNL-NGPLYLGGLPPLLLLPAL---PVRAGFVGCIRDVRVNGE 126
Cadherin pfam00028
Cadherin domain;
1136-1232 2.62e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 2.62e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1136 YYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEY--FRINATTGEIFNKQILKYQnvtgfsnvNINRHSFIVT 1213
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRE--------SIGEYELTVE 72

                           90
                   ....*....|....*....
gi 767932611  1214 SSDRGKPSLISETTVTINI 1232
Cdd:pfam00028   73 ATDSGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1562-1655 3.86e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.19  E-value: 3.86e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1562 YYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNfGSIR 1641
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGP 79

                           90
                   ....*....|....
gi 767932611  1642 GADiDEVTVNVTVL 1655
Cdd:pfam00028   80 PLS-STATVTITVL 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2121-2157 1.07e-15

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 73.05  E-value: 1.07e-15
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767932611 2121 DIDECL-PSPCHSGGTCHNLVGGFSCSCPDGFTGRACE 2157
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1581-1661 1.42e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 1.42e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   1581 ASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRgaDIDEVTVNVTVLDANDP 1660
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLDVNDN 79


                    .
gi 767932611   1661 P 1661
Cdd:smart00112   80 A 80
Cadherin pfam00028
Cadherin domain;
831-919 3.88e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 3.88e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   831 QTFMFPENQPVSSLVTTITGSSLRGEP---MSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPP 907
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 767932611   908 FSSYEKLDITVL 919
Cdd:pfam00028   81 LSSTATVTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
2121-2157 2.54e-14

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 69.20  E-value: 2.54e-14
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767932611   2121 DIDECL-PSPCHSGGTCHNLVGGFSCSCPDGFT-GRACE 2157
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2159-2195 2.28e-13

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 66.51  E-value: 2.28e-13
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767932611 2159 DINECLQ-SPCKNGAICQNFPGSFNCVCKTGYTGKMCE 2195
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
2159-2195 2.04e-12

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 63.81  E-value: 2.04e-12
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767932611   2159 DINECLQ-SPCKNGAICQNFPGSFNCVCKTGYT-GKMCE 2195
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
730-815 5.51e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 5.51e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   730 YVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSE-KFHIDPLRGAIMAAGPLN--GASEVTFSVHVKDGGSFP 806
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDreSIGEYELTVEATDSGGPP 80


                   ....*....
gi 767932611   807 KTDSTTVTV 815
Cdd:pfam00028   81 LSSTATVTI 89
EGF_CA pfam07645
Calcium-binding EGF domain;
2121-2150 3.76e-09

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 54.17  E-value: 3.76e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767932611  2121 DIDECL--PSPCHSGGTCHNLVGGFSCSCPDG 2150
Cdd:pfam07645    1 DVDECAtgTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2198-2233 3.64e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 3.64e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767932611 2198 VNYCE-CNPCFNGGSCQSGVDSYYCHCPFGVFGKHCE 2233
Cdd:cd00054     2 IDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2163-2192 1.90e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 49.30  E-value: 1.90e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 767932611  2163 CLQSPCKNGAICQNFPGSFNCVCKTGYTGK 2192
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2688-2722 1.98e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.98e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767932611 2688 DCAS-HPCQNGGSCEPgLHSGFTCSCPDSHTGRTCE 2722
Cdd:cd00054     4 ECASgNPCQNGGTCVN-TVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
2198-2233 5.97e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 5.97e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 767932611   2198 VNYCE-CNPCFNGGSCQSGVDSYYCHCPFG-VFGKHCE 2233
Cdd:smart00179    2 IDECAsGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2425-2455 1.38e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.99  E-value: 1.38e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767932611  2425 CTRSPCQHGGTCMDYWSWQQCHCKEGLTGKY 2455
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2201-2231 6.34e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.07  E-value: 6.34e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767932611  2201 CECNPCFNGGSCQSGVDSYYCHCPFGVFGKH 2231
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
2688-2722 2.10e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 2.10e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 767932611   2688 DCAS-HPCQNGGSCEPgLHSGFTCSCPDSHT-GRTCE 2722
Cdd:smart00179    4 ECASgNPCQNGGTCVN-TVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2426-2457 2.52e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 2.52e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767932611 2426 TRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCE 2457
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2689-2720 4.83e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.76  E-value: 4.83e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767932611  2689 CASHPCQNGGSCEPGLHsGFTCSCPDSHTGRT 2720
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG-GYTCICPEGYTGKR 31
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 585-822 5.78e-04

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 45.80  E-value: 5.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  585 ERFVLMITATDSgspALTGTGTINVIVDDVNdNVPTFASKAYFTTIPEDAPTgtdvLLVNASDADASknaVISYR--IIG 662
Cdd:NF038112 1346 TQLTFTLTVSDG---TASATDTVTVTVRNVN-RAPVANAGADQTVDERSTVT----LSGSATDPDGD---ALTYAwtQTA 1414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  663 GNSQFTINPSTGQIITSALlDRETKDNYTLVVVCSDAGSpepLSSSTSVLVTVTDVNdnpprfqHHPYVTHIPSPT-LPG 741
Cdd:NF038112 1415 GPTVTLTGADTATASFTAP-EVAADTELTFQLTVSADGQ---ASADVTVTVTVRNVN-------RAPVAHAGESITvDEG 1483

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  742 SFV-FAVTVTDADigpNSELHY----------SLSGRNSEKfhidplrgAIMAAGPLNGASEVTFSVHVKDGGSFPKTDS 810
Cdd:NF038112 1484 STVtLDASATDPD---GDTLTYawtqvagpsvTLTGADSAK--------LTFTAPEVSADTTLTFSLTVTDGSGSSGPVV 1552

                         250
                  ....*....|..
gi 767932611  811 TTVTVRFVNKAD 822
Cdd:NF038112 1553 VTVTVKNVNRAP 1564
EGF_CA smart00179
Calcium-binding EGF-like domain;
2426-2457 2.17e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.17e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 767932611   2426 TRSPCQHGGTCMDYWSWQQCHCKEGLT-GKYCE 2457
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 416-511 1.06e-36

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 134.75  E-value: 1.06e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  416 YKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTP 495
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*.
gi 767932611  496 RTDTSTVSIVLLDIND 511
Cdd:cd11304    82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 626-721 6.07e-35

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 129.74  E-value: 6.07e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  626 YFTTIPEDAPTGTDVLLVNASDADASKNAVISYRIIGGNSQ--FTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPe 703
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP- 80

                          90
                  ....*....|....*...
gi 767932611  704 PLSSSTSVLVTVTDVNDN 721
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1667-1765 1.15e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1667 IYSVQISEGVPIGTHVTFVSAFDSDSiPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGT 1746
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 767932611 1747 PSATGSASLLVTLEDINDN 1765
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1352-1449 1.98e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.50  E-value: 1.98e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1352 HMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWV 1431
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 767932611 1432 ARTGYCSVTVNVIDVNDN 1449
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 314-407 2.21e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.50  E-value: 2.21e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  314 TYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLL-NPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLS 392
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                          90
                  ....*....|....*
gi 767932611  393 SSTEVVVMVLDINDN 407
Cdd:cd11304    84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 205-304 1.05e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.50  E-value: 1.05e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  205 SYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVD-KNGVLKVLKALDRESQSFYNLVVQVHDLPQI 283
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90       100
                  ....*....|....*....|.
gi 767932611  284 PasrFTSTAQVSIILLDVNDN 304
Cdd:cd11304    81 P---LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 932-1028 7.94e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 7.94e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  932 PFISEILENLSP-RKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSP 1010
Cdd:cd11304     1 SYEVSVPENAPPgTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 767932611 1011 SQSTSVKVMINILDENDN 1028
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 102-197 2.24e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 111.25  E-value: 2.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  102 VYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGG- 180
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                          90
                  ....*....|....*...
gi 767932611  181 -QFTTIRVYFNILDVNDN 197
Cdd:cd11304    81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 520-617 3.06e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 3.06e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  520 PYSVNVPENL--GTLprtILQVVARDDDRGSNSKLSYVLFGGNEDNAFTL-SASGELGVTQSLDRETKERFVLMITATDS 596
Cdd:cd11304     1 SYEVSVPENAppGTV---VLTVSATDPDSGENGEVTYSIVSGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 767932611  597 GSPALTGTGTINVIVDDVNDN 617
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
416-507 3.12e-28

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 110.47  E-value: 3.12e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   416 YKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTP 495
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 767932611   496 RTDTSTVSIVLL 507
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 435-514 3.45e-28

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 109.75  E-value: 3.45e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    435 AADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVP 514
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1035-1127 9.35e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.33  E-value: 9.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1035 IFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIM--DASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG-- 1110
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                          90
                  ....*....|....*...
gi 767932611 1111 -WTVSTDVTIFVTDINDN 1127
Cdd:cd11304    81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 4-94 2.47e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 2.47e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    4 LTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDS-FRIDPESGDLIATRRLDRERRSKYSLLVRADDG---LQS 79
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpPLS 83

                          90
                  ....*....|....*
gi 767932611   80 SDMRINITVSDVNDH 94
Cdd:cd11304    84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1458-1552 4.34e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 4.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1458 YFPTVLENAPSGTTVIHLNATDADSGTNAVIAYT-VQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEE 1536
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*.
gi 767932611 1537 RCSFATVNIQLKGTNE 1552
Cdd:cd11304    82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1773-1869 5.02e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 5.02e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1773 EGEVMENKRPGTLVMTLQSTDPDLPPNqGPFTYYLLStGPATSYFSL-STAGVLSTTREIDREQIADFYLSVVTKDSGVP 1851
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGEN-GEVTYSIVS-GNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 767932611 1852 QMSSTGTVHITVIDQNDN 1869
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 950-1030 9.49e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 105.89  E-value: 9.49e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    950 SAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNA 1029
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 767932611   1030 P 1030
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1371-1451 1.84e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 105.12  E-value: 1.84e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   1371 SARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNS 1450
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 767932611   1451 P 1451
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 644-723 2.07e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 104.74  E-value: 2.07e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    644 NASDADASKNAVISYRIIGGN--SQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPePLSSSTSVLVTVTDVNDN 721
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDN 79


                    ..
gi 767932611    722 PP 723
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
316-402 2.38e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 102.38  E-value: 2.38e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   316 IPENTPIDTVVFKAQATDPDSGPNSYIEYTLLN-PLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSS 394
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 767932611   395 TEVVVMVL 402
Cdd:pfam00028   85 ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1247-1342 2.50e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 2.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1247 YFTPVTKNVKVGTKLIRVTAIDdKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNP 1326
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATD-PDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*.
gi 767932611 1327 PLSSQATVHITVTEEN 1342
Cdd:cd11304    81 PLSSTATVTITVLDVN 96
Cadherin pfam00028
Cadherin domain;
1668-1760 2.73e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 101.99  E-value: 2.73e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1668 YSVQISEGVPIGTHVTFVSAFDSDSIPSWsRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTP 1747
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNG-RIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 767932611  1748 SATGSASLLVTLE 1760
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 330-409 3.21e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 101.66  E-value: 3.21e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    330 QATDPDSGPNSYIEYTLL-NPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNN 408
Cdd:smart00112    1 SATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 767932611    409 P 409
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1135-1238 3.79e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 3.79e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1135 SYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSE--YFRINATTGEIFNKQILKYQnvtgfsnvNINRHSFIV 1212
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDRE--------EQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 767932611 1213 TSSDRGKPSLISETTVTINIVDSNDN 1238
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1354-1444 4.44e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 101.61  E-value: 4.44e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1354 SATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVAR 1433
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 767932611  1434 TGYCSVTVNVI 1444
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
626-716 1.04e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.45  E-value: 1.04e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   626 YFTTIPEDAPTGTDVLLVNASDADASKNAVISYRIIGGNS--QFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPe 703
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP- 79

                           90
                   ....*....|...
gi 767932611   704 PLSSSTSVLVTVT 716
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1562-1659 2.73e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 2.73e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1562 YYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSir 1641
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-- 79

                          90
                  ....*....|....*...
gi 767932611 1642 GADIDEVTVNVTVLDAND 1659
Cdd:cd11304    80 PPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1686-1767 2.89e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.58  E-value: 2.89e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   1686 SAFDSDSIPSWsRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDN 1765
Cdd:smart00112    1 SATDADSGENG-KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 767932611   1766 GP 1767
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 830-924 4.61e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 4.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  830 EQTFMFPENQPVSSLVTTITGS---SLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFP 906
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 767932611  907 PFSSYEKLDITVLDVNDN 924
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
936-1023 6.64e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.45  E-value: 6.64e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   936 EILENLSP-RKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQST 1014
Cdd:pfam00028    4 SVPENAPVgTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 767932611  1015 SVKVMINIL 1023
Cdd:pfam00028   84 TATVTITVL 92
Cadherin pfam00028
Cadherin domain;
206-299 7.98e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.06  E-value: 7.98e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   206 YSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDK-NGVLKVLKALDRESQSFYNLVVQVHDLPQIP 284
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPdTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....*
gi 767932611   285 ASrftSTAQVSIILL 299
Cdd:pfam00028   81 LS---STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 224-306 1.20e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.95  E-value: 1.20e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    224 NVTDADDGINSQLTYSIASGDSLGQFTVDKN-GVLKVLKALDRESQSFYNLVVQVHDLPQIPASrftSTAQVSIILLDVN 302
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLS---STATVTITVLDVN 77


                    ....
gi 767932611    303 DNPP 306
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 540-619 5.86e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 5.86e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    540 VARDDDRGSNSKLSYVLFGGNEDNAFTL-SASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNV 618
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 767932611    619 P 619
Cdd:smart00112   81 P 81
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2236-2399 8.78e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 94.41  E-value: 8.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 2236 SYGFEELSYMEFPSLDP--NNNYIYVKFATIKSHALLLYNYDNQTGDraeFLALEIAEERLRFSYNLGSGTYKLTTMKKV 2313
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAprTRLSISFSFRTTSPNGLLLYAGSQNGGD---FLALELEDGRLVLRYDLGSGSLVLSSKTPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 2314 SDGHFHTVIARRAGMAASLTVDSCSenqepgycTVSNVAVSDDWTLDVQPNrVTVGGirsLEPILQRRGHVESHDFVGCI 2393
Cdd:cd00110    78 NDGQWHSVSVERNGRSVTLSVDGER--------VVESGSPGGSALLNLDGP-LYLGG---LPEDLKSPGLPVSPGFVGCI 145


                  ....*.
gi 767932611 2394 MEFAVN 2399
Cdd:cd00110   146 RDLKVN 151
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 20-96 2.10e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 2.10e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611     20 TAMDADEGANALVTYTIISGADDS-FRIDPESGDLIATRRLDRERRSKYSLLVRADDG---LQSSDMRINITVSDVNDHT 95
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 767932611     96 P 96
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1773-1864 2.75e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.82  E-value: 2.75e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1773 EGEVMENKRPGTLVMTLQSTDPDLPPNQGPFtyYLLSTGPATSYFSLSTA-GVLSTTREIDREQIADFYLSVVTKDSGVP 1851
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF--YSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 767932611  1852 QMSSTGTVHITVI 1864
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 122-199 4.70e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.72  E-value: 4.70e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    122 ATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQ--FTTIRVYFNILDVNDNPP 199
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
5-88 4.44e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.36  E-value: 4.44e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611     5 TVEENIGDGSKIMQLTAMDADEGANALVTYTIISG-ADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADDGL---QSS 80
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgppLSS 83


                   ....*...
gi 767932611    81 DMRINITV 88
Cdd:pfam00028   84 TATVTITV 91
Cadherin pfam00028
Cadherin domain;
103-192 2.11e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 2.11e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   103 YSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGG--G 180
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|..
gi 767932611   181 QFTTIRVYFNIL 192
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1461-1547 3.46e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 3.46e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1461 TVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSD-LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCS 1539
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*...
gi 767932611  1540 FATVNIQL 1547
Cdd:pfam00028   84 TATVTITV 91
Cadherin pfam00028
Cadherin domain;
521-611 5.26e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.27  E-value: 5.26e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   521 YSVNVPENL--GTlprTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTL-SASGELGVTQSLDRETKERFVLMITATDSG 597
Cdd:pfam00028    1 YSASVPENApvGT---EVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....
gi 767932611   598 SPALTGTGTINVIV 611
Cdd:pfam00028   78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 859-926 7.28e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 7.28e-19
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767932611    859 SYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAP 926
Cdd:smart00112   14 TYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1054-1129 7.64e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 7.64e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   1054 TTSDEDIGINAISRYSIMD--ASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNA 1128
Cdd:smart00112    1 SATDADSGENGKVTYSILSgnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgppLSSTATVTITVLDVNDNA 80


                    .
gi 767932611   1129 P 1129
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1155-1240 1.73e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 1.73e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   1155 ATDPDEGSNGQVFYFIKSQSE--YFRINATTGEIFNKQILKYQNvtgfsnvnINRHSFIVTSSDRGKPSLISETTVTINI 1232
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREE--------QPEYTLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 767932611   1233 VDSNDNAP 1240
Cdd:smart00112   74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1247-1339 4.75e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 4.75e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1247 YFTPVTKNVKVGTKLIRVTAIDdKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNP 1326
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATD-PDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 767932611  1327 PLSSQATVHITVT 1339
Cdd:pfam00028   80 PLSSTATVTITVL 92
LamG smart00282
Laminin G domain;
2256-2401 4.95e-18

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 82.77  E-value: 4.95e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   2256 YIYVKFATIKSHALLLYNYDNQTGDraeFLALEIAEERLRFSYNLGSGTYKLT-TMKKVSDGHFHTVIARRAGMAASLTV 2334
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGD---YLALELRDGRLVLRYDLGSGPARLTsDPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767932611   2335 DSCSEnqepgyctVSNVAVSDDWTLDVqPNRVTVGGirsLEPILQRRGHVESHDFVGCIMEFAVNGR 2401
Cdd:smart00282   78 DGGNR--------VSGESPGGLTILNL-DGPLYLGG---LPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 729-816 8.60e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 8.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  729 PYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRN-SEKFHIDPLRGAIMAAGPLN--GASEVTFSVHVKDGGSF 805
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|.
gi 767932611  806 PKTDSTTVTVR 816
Cdd:cd11304    81 PLSSTATVTIT 91
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2504-2625 1.47e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 82.08  E-value: 1.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 2504 SLEVKFRTRSENGVLIHI--QESSNYTTVKIKNGKVYFTSDAGIAGKVERniPEVYVADGHWHTFLIGKNGTATVLSVDR 2581
Cdd:cd00110    23 SISFSFRTTSPNGLLLYAgsQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPLNDGQWHSVSVERNGRSVTLSVDG 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 767932611 2582 IYNRDIIHPTQDFGGLDVLTISLGGIPPNQ-AHRDAQTAGFDGCI 2625
Cdd:cd00110   101 ERVVESGSPGGSALLNLDGPLYLGGLPEDLkSPGLPVSPGFVGCI 145
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1269-1346 2.89e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 2.89e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767932611   1269 DKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTP 1346
Cdd:smart00112    4 DADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1792-1870 3.19e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 3.19e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   1792 TDPDLPPNqGPFTYYLLStGPATSYFSL-STAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNP 1870
Cdd:smart00112    3 TDADSGEN-GKVTYSILS-GNDDGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1476-1555 4.10e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 4.10e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   1476 NATDADSGTNAVIAYT-VQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYV 1554
Cdd:smart00112    1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 767932611   1555 P 1555
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1036-1122 4.50e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.50  E-value: 4.50e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1036 FSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIM--DASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG--- 1110
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpp 80

                           90
                   ....*....|..
gi 767932611  1111 WTVSTDVTIFVT 1122
Cdd:pfam00028   81 LSSTATVTITVL 92
LamG smart00282
Laminin G domain;
2504-2633 6.10e-17

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 79.69  E-value: 6.10e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   2504 SLEVKFRTRSENGVLIHIQES--SNYTTVKIKNGKVYFTSDAGiAGKVERNIPEVYVADGHWHTFLIGKNGTATVLSVDR 2581
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKggGDYLALELRDGRLVLRYDLG-SGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 767932611   2582 IYNRDIIHPTQDFgGLDVLT-ISLGGIPPNQ-AHRDAQTAGFDGCIASMWYGGE 2633
Cdd:smart00282   80 GNRVSGESPGGLT-ILNLDGpLYLGGLPEDLkLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2509-2633 9.24e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 79.00  E-value: 9.24e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  2509 FRTRSENGVLIHI-QESSNYTTVKIKNGKVYFTSDAGiAGKVERNIPEVYVADGHWHTFLIGKNGTATVLSVDRIYNRDI 2587
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLVLRYDLG-SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 767932611  2588 IHPTQDFGGLDVLTISLGGIPP-NQAHRDAQTAGFDGCIASMWYGGE 2633
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLPPlLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2261-2401 2.61e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 77.85  E-value: 2.61e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  2261 FATIKSHALLLYNydnqTGDRAEFLALEIAEERLRFSYNLGSGTYKLT-TMKKVSDGHFHTVIARRAGMAASLTVDSCSe 2339
Cdd:pfam02210    1 FRTRQPNGLLLYA----GGGGSDFLALELVNGRLVLRYDLGSGPESLLsSGKNLNDGQWHSVRVERNGNTLTLSVDGQT- 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767932611  2340 nqepgycTVSNVAVSDDWTLDVqPNRVTVGGIRSLEPILQRrghVESHDFVGCIMEFAVNGR 2401
Cdd:pfam02210   76 -------VVSSLPPGESLLLNL-NGPLYLGGLPPLLLLPAL---PVRAGFVGCIRDVRVNGE 126
Cadherin pfam00028
Cadherin domain;
1136-1232 2.62e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 2.62e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1136 YYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEY--FRINATTGEIFNKQILKYQnvtgfsnvNINRHSFIVT 1213
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRE--------SIGEYELTVE 72

                           90
                   ....*....|....*....
gi 767932611  1214 SSDRGKPSLISETTVTINI 1232
Cdd:pfam00028   73 ATDSGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1562-1655 3.86e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.19  E-value: 3.86e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1562 YYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNfGSIR 1641
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGP 79

                           90
                   ....*....|....
gi 767932611  1642 GADiDEVTVNVTVL 1655
Cdd:pfam00028   80 PLS-STATVTITVL 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2121-2157 1.07e-15

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 73.05  E-value: 1.07e-15
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767932611 2121 DIDECL-PSPCHSGGTCHNLVGGFSCSCPDGFTGRACE 2157
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1581-1661 1.42e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 1.42e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   1581 ASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRgaDIDEVTVNVTVLDANDP 1660
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLDVNDN 79


                    .
gi 767932611   1661 P 1661
Cdd:smart00112   80 A 80
Laminin_G_1 pfam00054
Laminin G domain;
2261-2404 2.64e-15

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 75.05  E-value: 2.64e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  2261 FATIKSHALLLYNydnQTGDRAEFLALEIAEERLRFSYNLGSGTYKLTTMKKVSDGHFHTVIARRAGMAASLTVDscsEN 2340
Cdd:pfam00054    1 FRTTEPSGLLLYN---GTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVD---GE 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767932611  2341 QEPGYCTVSNVAVsddwTLDVqPNRVTVGGIRSLepILQRRGHVESHDFVGCIMEFAVNGRPLE 2404
Cdd:pfam00054   75 ARPTGESPLGATT----DLDV-DGPLYVGGLPSL--GVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Cadherin pfam00028
Cadherin domain;
831-919 3.88e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 3.88e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   831 QTFMFPENQPVSSLVTTITGSSLRGEP---MSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPP 907
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 767932611   908 FSSYEKLDITVL 919
Cdd:pfam00028   81 LSSTATVTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
2121-2157 2.54e-14

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 69.20  E-value: 2.54e-14
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767932611   2121 DIDECL-PSPCHSGGTCHNLVGGFSCSCPDGFT-GRACE 2157
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2159-2195 2.28e-13

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 66.51  E-value: 2.28e-13
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767932611 2159 DINECLQ-SPCKNGAICQNFPGSFNCVCKTGYTGKMCE 2195
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
2159-2195 2.04e-12

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 63.81  E-value: 2.04e-12
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767932611   2159 DINECLQ-SPCKNGAICQNFPGSFNCVCKTGYT-GKMCE 2195
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
730-815 5.51e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 5.51e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   730 YVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSE-KFHIDPLRGAIMAAGPLN--GASEVTFSVHVKDGGSFP 806
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDreSIGEYELTVEATDSGGPP 80


                   ....*....
gi 767932611   807 KTDSTTVTV 815
Cdd:pfam00028   81 LSSTATVTI 89
Laminin_G_1 pfam00054
Laminin G domain;
2509-2635 6.12e-12

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 65.42  E-value: 6.12e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  2509 FRTRSENGVLIHI--QESSNYTTVKIKNGKVYFTSDAGIAGKVERniPEVYVADGHWHTFLIGKNGTATVLSVDRIYNRD 2586
Cdd:pfam00054    1 FRTTEPSGLLLYNgtQTERDFLALELRDGRLEVSYDLGSGAAVVR--SGDKLNDGKWHSVELERNGRSGTLSVDGEARPT 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767932611  2587 IIHPTQDFGGLDVLT-ISLGGIPPNQAHRDAQTA--GFDGCIASMWYGGESL 2635
Cdd:pfam00054   79 GESPLGATTDLDVDGpLYVGGLPSLGVKKRRLAIspSFDGCIRDVIVNGKPL 130
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2124-2157 7.12e-10

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 56.33  E-value: 7.12e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767932611 2124 EC-LPSPCHSGGTCHNLVGGFSCSCPDGFTGRA-CE 2157
Cdd:cd00053     1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTGDRsCE 36
EGF_CA pfam07645
Calcium-binding EGF domain;
2121-2150 3.76e-09

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 54.17  E-value: 3.76e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767932611  2121 DIDECL--PSPCHSGGTCHNLVGGFSCSCPDG 2150
Cdd:pfam07645    1 DVDECAtgTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2198-2233 3.64e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 3.64e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767932611 2198 VNYCE-CNPCFNGGSCQSGVDSYYCHCPFGVFGKHCE 2233
Cdd:cd00054     2 IDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2125-2154 4.47e-08

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 51.23  E-value: 4.47e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 767932611  2125 CLPSPCHSGGTCHNLVGGFSCSCPDGFTGR 2154
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2162-2195 4.92e-08

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 51.32  E-value: 4.92e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767932611 2162 ECLQS-PCKNGAICQNFPGSFNCVCKTGYTGKM-CE 2195
Cdd:cd00053     1 ECAASnPCSNGGTCVNTPGSYRCVCPPGYTGDRsCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2163-2192 1.90e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 49.30  E-value: 1.90e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 767932611  2163 CLQSPCKNGAICQNFPGSFNCVCKTGYTGK 2192
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2688-2722 1.98e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.98e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767932611 2688 DCAS-HPCQNGGSCEPgLHSGFTCSCPDSHTGRTCE 2722
Cdd:cd00054     4 ECASgNPCQNGGTCVN-TVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
2198-2233 5.97e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 5.97e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 767932611   2198 VNYCE-CNPCFNGGSCQSGVDSYYCHCPFG-VFGKHCE 2233
Cdd:smart00179    2 IDECAsGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF smart00181
Epidermal growth factor-like domain;
2124-2157 1.20e-06

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 47.13  E-value: 1.20e-06
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767932611   2124 ECLP-SPCHsGGTCHNLVGGFSCSCPDGFTG-RACE 2157
Cdd:smart00181    1 ECASgGPCS-NGTCINTPGSYTCSCPPGYTGdKRCE 35
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2425-2455 1.38e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.99  E-value: 1.38e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767932611  2425 CTRSPCQHGGTCMDYWSWQQCHCKEGLTGKY 2455
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA pfam07645
Calcium-binding EGF domain;
2159-2188 1.71e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.85  E-value: 1.71e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767932611  2159 DINECL--QSPCKNGAICQNFPGSFNCVCKTG 2188
Cdd:pfam07645    1 DVDECAtgTHNCPANTVCVNTIGSFECRCPDG 32
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1683-1765 3.25e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 48.11  E-value: 3.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611 1683 TFVSAFDSDSIPSWSRFSYFIGSGNEN--GAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLE 1760
Cdd:cd00031    14 SFRVSIPTDLIASSGEIIKISAAGKEAlpSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVY 93


                  ....*
gi 767932611 1761 DINDN 1765
Cdd:cd00031    94 DENDN 98
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2201-2231 6.34e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.07  E-value: 6.34e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767932611  2201 CECNPCFNGGSCQSGVDSYYCHCPFGVFGKH 2231
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
2688-2722 2.10e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 2.10e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 767932611   2688 DCAS-HPCQNGGSCEPgLHSGFTCSCPDSHT-GRTCE 2722
Cdd:smart00179    4 ECASgNPCQNGGTCVN-TVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2202-2233 2.17e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 43.62  E-value: 2.17e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767932611 2202 EC---NPCFNGGSCQSGVDSYYCHCPFGVFG-KHCE 2233
Cdd:cd00053     1 ECaasNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2426-2457 2.52e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 2.52e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767932611 2426 TRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCE 2457
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 2130-2151 2.59e-05

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 43.09  E-value: 2.59e-05
                           10        20
                   ....*....|....*....|..
gi 767932611  2130 CHSGGTCHNLVGGFSCSCPDGF 2151
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF smart00181
Epidermal growth factor-like domain;
2162-2195 2.72e-05

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 43.27  E-value: 2.72e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767932611   2162 ECLQ-SPCKNGaICQNFPGSFNCVCKTGYTG-KMCE 2195
Cdd:smart00181    1 ECASgGPCSNG-TCINTPGSYTCSCPPGYTGdKRCE 35
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3-94 3.75e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 45.03  E-value: 3.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611    3 DLTVEENIGDGSKIMQLTAmdaDEGANALVTYTIISGADDS----FRIDPESGDLIATRRLDRERRSKY---SLLVRADD 75
Cdd:cd00031     3 DGSAVEGRSRGSFRVSIPT---DLIASSGEIIKISAAGKEAlpswLHWEPHSGILEGLEKLDREDKGVHyisVSAASLGA 79

                          90
                  ....*....|....*....
gi 767932611   76 GLQSSDMRINITVSDVNDH 94
Cdd:cd00031    80 NVPQTSSVFSIEVYDENDN 98
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2689-2720 4.83e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.76  E-value: 4.83e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767932611  2689 CASHPCQNGGSCEPGLHsGFTCSCPDSHTGRT 2720
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG-GYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2688-2722 5.84e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 42.46  E-value: 5.84e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767932611 2688 DCA-SHPCQNGGSCEPgLHSGFTCSCPDSHTG-RTCE 2722
Cdd:cd00053     1 ECAaSNPCSNGGTCVN-TPGSYRCVCPPGYTGdRSCE 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2167-2191 6.05e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.59  E-value: 6.05e-05
                           10        20
                   ....*....|....*....|....*
gi 767932611  2167 PCKNGAICQNFPGSFNCVCKTGYTG 2191
Cdd:pfam12947    7 GCHPNATCTNTGGSFTCTCNDGYTG 31
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2127-2153 7.50e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.20  E-value: 7.50e-05
                           10        20
                   ....*....|....*....|....*..
gi 767932611  2127 PSPCHSGGTCHNLVGGFSCSCPDGFTG 2153
Cdd:pfam12947    5 NGGCHPNATCTNTGGSFTCTCNDGYTG 31
Cadherin_4 pfam17803
Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains ...
 606-671 3.01e-04

Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains found in extracelullar proteins.


Pssm-ID: 465514 [Multi-domain]  Cd Length: 71  Bit Score: 41.40  E-value: 3.01e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767932611   606 TINVIVDDVNDNvPTFASKAYftTIPEDAP-TGTDVLLVNASDADASKNAVISYRIIGGNSQFTINP 671
Cdd:pfam17803    2 TVTITVTGVNDA-PVAVDDTA--TVDEDTPvTITGNVLANDTDVDGDTLTVTSVTGAPAYGTLTLNA 65
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2425-2457 4.25e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 40.15  E-value: 4.25e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767932611 2425 CTRS-PCQHGGTCMDYWSWQQCHCKEGLTG-KYCE 2457
Cdd:cd00053     2 CAASnPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 585-822 5.78e-04

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 45.80  E-value: 5.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  585 ERFVLMITATDSgspALTGTGTINVIVDDVNdNVPTFASKAYFTTIPEDAPTgtdvLLVNASDADASknaVISYR--IIG 662
Cdd:NF038112 1346 TQLTFTLTVSDG---TASATDTVTVTVRNVN-RAPVANAGADQTVDERSTVT----LSGSATDPDGD---ALTYAwtQTA 1414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  663 GNSQFTINPSTGQIITSALlDRETKDNYTLVVVCSDAGSpepLSSSTSVLVTVTDVNdnpprfqHHPYVTHIPSPT-LPG 741
Cdd:NF038112 1415 GPTVTLTGADTATASFTAP-EVAADTELTFQLTVSADGQ---ASADVTVTVTVRNVN-------RAPVAHAGESITvDEG 1483

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  742 SFV-FAVTVTDADigpNSELHY----------SLSGRNSEKfhidplrgAIMAAGPLNGASEVTFSVHVKDGGSFPKTDS 810
Cdd:NF038112 1484 STVtLDASATDPD---GDTLTYawtqvagpsvTLTGADSAK--------LTFTAPEVSADTTLTFSLTVTDGSGSSGPVV 1552

                         250
                  ....*....|..
gi 767932611  811 TTVTVRFVNKAD 822
Cdd:NF038112 1553 VTVTVKNVNRAP 1564
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 2168-2189 6.14e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 39.24  E-value: 6.14e-04
                           10        20
                   ....*....|....*....|..
gi 767932611  2168 CKNGAICQNFPGSFNCVCKTGY 2189
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 2206-2224 9.92e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 38.85  E-value: 9.92e-04
                           10
                   ....*....|....*....
gi 767932611  2206 CFNGGSCQSGVDSYYCHCP 2224
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCP 19
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2694-2721 1.43e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 1.43e-03
                           10        20
                   ....*....|....*....|....*...
gi 767932611  2694 CQNGGSCEpglHSGFTCSCPDSHTGRTC 2721
Cdd:pfam07974    2 CSGRGTCV---NQCGKCVCDSGYQGATC 26
EGF_CA smart00179
Calcium-binding EGF-like domain;
2426-2457 2.17e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.17e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 767932611   2426 TRSPCQHGGTCMDYWSWQQCHCKEGLT-GKYCE 2457
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Big_9 pfam17963
Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains.
 1647-1728 3.89e-03

Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains.


Pssm-ID: 465590 [Multi-domain]  Cd Length: 90  Bit Score: 38.86  E-value: 3.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611  1647 EVTVNVTVLDANDPPIFTLNiySVQISEGVPigthVTFVSAFDSDSIpSWSRFSYFIGSGNENGAFSINPqTGQITVTAE 1726
Cdd:pfam17963    1 TATVTVTVTPVNDAPVAVDD--SVTVTEDTV----LANDSDPDGDPL-TITSLTVTIVTAPANGTVTVNA-DGTLTYTPN 72


                   ..
gi 767932611  1727 LD 1728
Cdd:pfam17963   73 AG 74
Cadherin_3 pfam16184
Cadherin-like;
187-279 5.25e-03

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 39.12  E-value: 5.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932611   187 VYFNILDVNDNPPIFSLNsysTSLMenLPVGSTVL----VFNVTDADDgINSQLTYSIASGDSlgqftvdkNGVLKVLKA 262
Cdd:pfam16184    7 FNITIIPVNDEAPVLTTN---TGLR--LWEGSSRPitpdLLQAEDPDT-PPEDLTYTVVQGPS--------HGHLALKGA 72

                           90       100
                   ....*....|....*....|...
gi 767932611   263 LDRESQSF------YNLVVQVHD 279
Cdd:pfam16184   73 PGLPVTNFtqadidSGLVVYVHD 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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