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Conserved domains on  [gi|767942222|ref|XP_011533876|]
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protein broad-minded isoform X7 [Homo sapiens]

Protein Classification

TBC domain-containing protein; TBC and TLD domain-containing protein( domain architecture ID 10633145)

TBC (Tre-2, BUB2p, Cdc16p) domain-containing protein may perform a GTP-activator activity on Rab-like GTPases| TBC (Tre-2/Bub2/Cdc1) and TLD domain-containing protein may function as a GTPase activator protein of Rab-like small GTPases; similar to Drosophila melanogaster GTPase-activating protein skywalker

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RabGAP-TBC super family cl46302
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 1-1207 0e+00

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


The actual alignment was detected with superfamily member pfam14961:

Pssm-ID: 480642  Cd Length: 1292  Bit Score: 2047.02  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222     1 MMHYLKNIMIAVVESMINKFEEDETRNQERQKKIQKEKSHSYRTDNCSDSDSSLNQSYKF-CQGKLQLILDQLDPGQPKE 79
Cdd:pfam14961   99 MMHSLKNVMMVVVESLINKFEEDQMRKEEMHRKSQHEQLSSHYTDNCSDSDSSFNQSYTFmSQEQLQLIAEKLDPRQPKE 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222    80 VRYEALQTLCSAPPSDVLNCENWTTLCEKLTVSLSDPDPVFSDRILKFCAQTFLLSPLHMTKEIYTSLAKYLESYFLSRE 159
Cdd:pfam14961  179 VRWEALQTLCHAPPSDVLSCESWTSLRRNLMAALSDPDPALSDKILRFYAKTFSSSPLNITREIYTSLAKHLESYFLSSK 258

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   160 NHIPTLSAGVDITNPNMTRLLKKVRLLNEYQKEAPSFWIRHPEKYMEEIVESTLSLLTVKHNQS--HVVSQKILDPIYFF 237
Cdd:pfam14961  259 LSFPSLSAGLDINNPDVARLLKKIRLLNEFQKEVPSFWIRHPEKYMEEIVESTLSLLSLHHEQGlnSPGSDKVLDPIYFL 338

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   238 ALVDTKAVWFKKWMHAHYSRTTVLRLLETKYKSLVTTAIQQCVQYFEMCKTRKAD----ETLGHSKHCRNKQKTFYyLGQ 313
Cdd:pfam14961  339 ALLDIKATWFKKWMHGYYSRTVVLRLLEKKYKSLIVAAVQQCIDYFESCEASVDKtteiSHSSHQQHIGNKQRTFY-TGK 417

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   314 ELQYIYFIHSLCLLGRLLIYKQGRKLFPIKLKNKKGLVSLIDLLVLFTQLIYYSPSCPKMTSAAHSENYSPASMVTEVLW 393
Cdd:pfam14961  418 ELQYIYFVHSLCLLGRLLIYTQGRKLFPIKLKNRKDPVSLTDLLVLLIRLIYYSPSLPKETPHVGSDNYSPASLVMEVLQ 497

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   394 ILSDQKECAVECLYNNIVIETLLQPIHNLMKGNEASPNCSETALIHIAGILARIASVEEGLILLLYGANMNSSEE-SPTG 472
Cdd:pfam14961  498 ILCDRKECAAECLYQDTVIETLLQPIITLLNGKEAKLNCSETTLIHIADILARIASTERGLSLLLYGGNLSSAEEeSISA 577

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   473 AHIIAQFSKKLLDEDISIFSGSEMLPVVKGAFISVCRHIYSTCEGLQVLITYNLHESIAKAWKKTSLLSERIPTPVEGSD 552
Cdd:pfam14961  578 AHVIVQFTKKLLDKEIPVLSGSELLPSLKGAFIFVCRQMYNTCEGLQVLLPYGLHESIAEAWKKASLLSERVPTPVPGAD 657

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   553 SVSSVSQESQNIMAWEDNLLDDLLHFAATPKGLLLLQRTGAINECVTFIFNRYAKKLQVSRHKKFGYGVLVTRVASTAAG 632
Cdd:pfam14961  658 CSSSVSQESQNVVVWEETLLDNLLNFAATPKGLLLLQQTGAINECVTYMFSRFTKKLQVSRCEKFGYGVMVTQVAATAPG 737

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   633 GIALKKSGFINELITELWSNLEYGRDDVRVTHPRTTPVDPIDRSCQKSFLALVNLL-SYPAIYELVRNQDLPNKTEYSLR 711
Cdd:pfam14961  738 AVALQSSGFVRALVLELWSVLECGRDDVRVTHPKSTPVDPIDRSCQKSFLALVNLLsSYPAVYELLGNQELPNKTEYSLR 817

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   712 EVPTCVIDIIDRLIILNSEAKIRSLFNYEQSHIFGLRLLSVICCDLDTLLLLEAQYQVSEMLLNAQEENILEISESHRDF 791
Cdd:pfam14961  818 EMPTSIIDLIDRLIIINSEAKIHSLFNYEQSHTFGLRLLSVLCCNLDSLLLLESQYNISEVLLQAQKENVTEPSGSEGEF 897

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   792 IIDGLSVERNHVLVRINLVGGPLERILPPRLLEKSDNPYPWPMFSSYPLPNCYLSDITRNAGIKQEmgpknkntifCVSG 871
Cdd:pfam14961  898 IIDGLSVERNHILVRINLIGGPSERILPPRALQKGEDPYPWPMFSSYPLPKCYLPDVPRITDTKQD----------SELS 967

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   872 AMQRSVNNdldklllclkiSDKQTEWIENCQRQFCKMMKAKPDIISGEALIELLEKFVLHLTESPSECYFPSVEYTATDA 951
Cdd:pfam14961  968 KFLSSSKN-----------PEKQAEWMENCRRQFCKIMKTKPDTISGGVLAELLEKFVLHLSESPSECYFSSTEYKAADA 1036

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   952 NVKNESLSSVQQLGIKMTVRYGKFLSLLKDGAENDLTWVLKHCERFLKQQQTSIKSSLLCLQGNYAGHDWFVSSLFMIML 1031
Cdd:pfam14961 1037 DVKNASLSSVQQLGVKMTIRYGKYLNLLKEDAENDLCLVLKHCEQFLKQQQVKVSSSLRCLQGGYPGHDWFASSVFLIMS 1116

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222  1032 GDKEKTFQFLHQFSRLLTSAFLWLPRLHISSYLPNDTVESGIHPVYFCSTHYIEMLLKAELPLVFSAFHMSGFAPSQICL 1111
Cdd:pfam14961 1117 GDKERSLSFLLRFSHLLVSAFLWPPRLHASIHLPADTAESGIHPVYSCTAHYVEMLLKAEVPLVFSAFRMSGFTPSQICL 1196

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222  1112 QWITQCFWNYLDWIEICHYIATCVFLGPDYQVYICIAVFKHLQQDILQHTQTQDLQVFLKEEALHGFRVSDYFEYMEILE 1191
Cdd:pfam14961 1197 QWLTQCFWNYLDWTEICHYIATCIFMGPDYQVYMCISILKHLQQEILQHTQTQDLQVFLKEEPIHGFRVSNYLEYMESLE 1276

                         1210
                   ....*....|....*.
gi 767942222  1192 QNYRTVLLRDMRNIRL 1207
Cdd:pfam14961 1277 QTYRPMVLTDMRNIRV 1292
 
Name Accession Description Interval E-value
BROMI pfam14961
Broad-minded protein; Broad-minded protein (BROMI) interacts with cell cycle-related kinase ...
 1-1207 0e+00

Broad-minded protein; Broad-minded protein (BROMI) interacts with cell cycle-related kinase (CCRK), together these proteins regulate ciliary membrane and axonemal growth.


Pssm-ID: 464406  Cd Length: 1292  Bit Score: 2047.02  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222     1 MMHYLKNIMIAVVESMINKFEEDETRNQERQKKIQKEKSHSYRTDNCSDSDSSLNQSYKF-CQGKLQLILDQLDPGQPKE 79
Cdd:pfam14961   99 MMHSLKNVMMVVVESLINKFEEDQMRKEEMHRKSQHEQLSSHYTDNCSDSDSSFNQSYTFmSQEQLQLIAEKLDPRQPKE 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222    80 VRYEALQTLCSAPPSDVLNCENWTTLCEKLTVSLSDPDPVFSDRILKFCAQTFLLSPLHMTKEIYTSLAKYLESYFLSRE 159
Cdd:pfam14961  179 VRWEALQTLCHAPPSDVLSCESWTSLRRNLMAALSDPDPALSDKILRFYAKTFSSSPLNITREIYTSLAKHLESYFLSSK 258

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   160 NHIPTLSAGVDITNPNMTRLLKKVRLLNEYQKEAPSFWIRHPEKYMEEIVESTLSLLTVKHNQS--HVVSQKILDPIYFF 237
Cdd:pfam14961  259 LSFPSLSAGLDINNPDVARLLKKIRLLNEFQKEVPSFWIRHPEKYMEEIVESTLSLLSLHHEQGlnSPGSDKVLDPIYFL 338

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   238 ALVDTKAVWFKKWMHAHYSRTTVLRLLETKYKSLVTTAIQQCVQYFEMCKTRKAD----ETLGHSKHCRNKQKTFYyLGQ 313
Cdd:pfam14961  339 ALLDIKATWFKKWMHGYYSRTVVLRLLEKKYKSLIVAAVQQCIDYFESCEASVDKtteiSHSSHQQHIGNKQRTFY-TGK 417

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   314 ELQYIYFIHSLCLLGRLLIYKQGRKLFPIKLKNKKGLVSLIDLLVLFTQLIYYSPSCPKMTSAAHSENYSPASMVTEVLW 393
Cdd:pfam14961  418 ELQYIYFVHSLCLLGRLLIYTQGRKLFPIKLKNRKDPVSLTDLLVLLIRLIYYSPSLPKETPHVGSDNYSPASLVMEVLQ 497

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   394 ILSDQKECAVECLYNNIVIETLLQPIHNLMKGNEASPNCSETALIHIAGILARIASVEEGLILLLYGANMNSSEE-SPTG 472
Cdd:pfam14961  498 ILCDRKECAAECLYQDTVIETLLQPIITLLNGKEAKLNCSETTLIHIADILARIASTERGLSLLLYGGNLSSAEEeSISA 577

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   473 AHIIAQFSKKLLDEDISIFSGSEMLPVVKGAFISVCRHIYSTCEGLQVLITYNLHESIAKAWKKTSLLSERIPTPVEGSD 552
Cdd:pfam14961  578 AHVIVQFTKKLLDKEIPVLSGSELLPSLKGAFIFVCRQMYNTCEGLQVLLPYGLHESIAEAWKKASLLSERVPTPVPGAD 657

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   553 SVSSVSQESQNIMAWEDNLLDDLLHFAATPKGLLLLQRTGAINECVTFIFNRYAKKLQVSRHKKFGYGVLVTRVASTAAG 632
Cdd:pfam14961  658 CSSSVSQESQNVVVWEETLLDNLLNFAATPKGLLLLQQTGAINECVTYMFSRFTKKLQVSRCEKFGYGVMVTQVAATAPG 737

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   633 GIALKKSGFINELITELWSNLEYGRDDVRVTHPRTTPVDPIDRSCQKSFLALVNLL-SYPAIYELVRNQDLPNKTEYSLR 711
Cdd:pfam14961  738 AVALQSSGFVRALVLELWSVLECGRDDVRVTHPKSTPVDPIDRSCQKSFLALVNLLsSYPAVYELLGNQELPNKTEYSLR 817

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   712 EVPTCVIDIIDRLIILNSEAKIRSLFNYEQSHIFGLRLLSVICCDLDTLLLLEAQYQVSEMLLNAQEENILEISESHRDF 791
Cdd:pfam14961  818 EMPTSIIDLIDRLIIINSEAKIHSLFNYEQSHTFGLRLLSVLCCNLDSLLLLESQYNISEVLLQAQKENVTEPSGSEGEF 897

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   792 IIDGLSVERNHVLVRINLVGGPLERILPPRLLEKSDNPYPWPMFSSYPLPNCYLSDITRNAGIKQEmgpknkntifCVSG 871
Cdd:pfam14961  898 IIDGLSVERNHILVRINLIGGPSERILPPRALQKGEDPYPWPMFSSYPLPKCYLPDVPRITDTKQD----------SELS 967

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   872 AMQRSVNNdldklllclkiSDKQTEWIENCQRQFCKMMKAKPDIISGEALIELLEKFVLHLTESPSECYFPSVEYTATDA 951
Cdd:pfam14961  968 KFLSSSKN-----------PEKQAEWMENCRRQFCKIMKTKPDTISGGVLAELLEKFVLHLSESPSECYFSSTEYKAADA 1036

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   952 NVKNESLSSVQQLGIKMTVRYGKFLSLLKDGAENDLTWVLKHCERFLKQQQTSIKSSLLCLQGNYAGHDWFVSSLFMIML 1031
Cdd:pfam14961 1037 DVKNASLSSVQQLGVKMTIRYGKYLNLLKEDAENDLCLVLKHCEQFLKQQQVKVSSSLRCLQGGYPGHDWFASSVFLIMS 1116

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222  1032 GDKEKTFQFLHQFSRLLTSAFLWLPRLHISSYLPNDTVESGIHPVYFCSTHYIEMLLKAELPLVFSAFHMSGFAPSQICL 1111
Cdd:pfam14961 1117 GDKERSLSFLLRFSHLLVSAFLWPPRLHASIHLPADTAESGIHPVYSCTAHYVEMLLKAEVPLVFSAFRMSGFTPSQICL 1196

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222  1112 QWITQCFWNYLDWIEICHYIATCVFLGPDYQVYICIAVFKHLQQDILQHTQTQDLQVFLKEEALHGFRVSDYFEYMEILE 1191
Cdd:pfam14961 1197 QWLTQCFWNYLDWTEICHYIATCIFMGPDYQVYMCISILKHLQQEILQHTQTQDLQVFLKEEPIHGFRVSNYLEYMESLE 1276

                         1210
                   ....*....|....*.
gi 767942222  1192 QNYRTVLLRDMRNIRL 1207
Cdd:pfam14961 1277 QTYRPMVLTDMRNIRV 1292
 
Name Accession Description Interval E-value
BROMI pfam14961
Broad-minded protein; Broad-minded protein (BROMI) interacts with cell cycle-related kinase ...
 1-1207 0e+00

Broad-minded protein; Broad-minded protein (BROMI) interacts with cell cycle-related kinase (CCRK), together these proteins regulate ciliary membrane and axonemal growth.


Pssm-ID: 464406  Cd Length: 1292  Bit Score: 2047.02  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222     1 MMHYLKNIMIAVVESMINKFEEDETRNQERQKKIQKEKSHSYRTDNCSDSDSSLNQSYKF-CQGKLQLILDQLDPGQPKE 79
Cdd:pfam14961   99 MMHSLKNVMMVVVESLINKFEEDQMRKEEMHRKSQHEQLSSHYTDNCSDSDSSFNQSYTFmSQEQLQLIAEKLDPRQPKE 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222    80 VRYEALQTLCSAPPSDVLNCENWTTLCEKLTVSLSDPDPVFSDRILKFCAQTFLLSPLHMTKEIYTSLAKYLESYFLSRE 159
Cdd:pfam14961  179 VRWEALQTLCHAPPSDVLSCESWTSLRRNLMAALSDPDPALSDKILRFYAKTFSSSPLNITREIYTSLAKHLESYFLSSK 258

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   160 NHIPTLSAGVDITNPNMTRLLKKVRLLNEYQKEAPSFWIRHPEKYMEEIVESTLSLLTVKHNQS--HVVSQKILDPIYFF 237
Cdd:pfam14961  259 LSFPSLSAGLDINNPDVARLLKKIRLLNEFQKEVPSFWIRHPEKYMEEIVESTLSLLSLHHEQGlnSPGSDKVLDPIYFL 338

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   238 ALVDTKAVWFKKWMHAHYSRTTVLRLLETKYKSLVTTAIQQCVQYFEMCKTRKAD----ETLGHSKHCRNKQKTFYyLGQ 313
Cdd:pfam14961  339 ALLDIKATWFKKWMHGYYSRTVVLRLLEKKYKSLIVAAVQQCIDYFESCEASVDKtteiSHSSHQQHIGNKQRTFY-TGK 417

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   314 ELQYIYFIHSLCLLGRLLIYKQGRKLFPIKLKNKKGLVSLIDLLVLFTQLIYYSPSCPKMTSAAHSENYSPASMVTEVLW 393
Cdd:pfam14961  418 ELQYIYFVHSLCLLGRLLIYTQGRKLFPIKLKNRKDPVSLTDLLVLLIRLIYYSPSLPKETPHVGSDNYSPASLVMEVLQ 497

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   394 ILSDQKECAVECLYNNIVIETLLQPIHNLMKGNEASPNCSETALIHIAGILARIASVEEGLILLLYGANMNSSEE-SPTG 472
Cdd:pfam14961  498 ILCDRKECAAECLYQDTVIETLLQPIITLLNGKEAKLNCSETTLIHIADILARIASTERGLSLLLYGGNLSSAEEeSISA 577

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   473 AHIIAQFSKKLLDEDISIFSGSEMLPVVKGAFISVCRHIYSTCEGLQVLITYNLHESIAKAWKKTSLLSERIPTPVEGSD 552
Cdd:pfam14961  578 AHVIVQFTKKLLDKEIPVLSGSELLPSLKGAFIFVCRQMYNTCEGLQVLLPYGLHESIAEAWKKASLLSERVPTPVPGAD 657

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   553 SVSSVSQESQNIMAWEDNLLDDLLHFAATPKGLLLLQRTGAINECVTFIFNRYAKKLQVSRHKKFGYGVLVTRVASTAAG 632
Cdd:pfam14961  658 CSSSVSQESQNVVVWEETLLDNLLNFAATPKGLLLLQQTGAINECVTYMFSRFTKKLQVSRCEKFGYGVMVTQVAATAPG 737

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   633 GIALKKSGFINELITELWSNLEYGRDDVRVTHPRTTPVDPIDRSCQKSFLALVNLL-SYPAIYELVRNQDLPNKTEYSLR 711
Cdd:pfam14961  738 AVALQSSGFVRALVLELWSVLECGRDDVRVTHPKSTPVDPIDRSCQKSFLALVNLLsSYPAVYELLGNQELPNKTEYSLR 817

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   712 EVPTCVIDIIDRLIILNSEAKIRSLFNYEQSHIFGLRLLSVICCDLDTLLLLEAQYQVSEMLLNAQEENILEISESHRDF 791
Cdd:pfam14961  818 EMPTSIIDLIDRLIIINSEAKIHSLFNYEQSHTFGLRLLSVLCCNLDSLLLLESQYNISEVLLQAQKENVTEPSGSEGEF 897

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   792 IIDGLSVERNHVLVRINLVGGPLERILPPRLLEKSDNPYPWPMFSSYPLPNCYLSDITRNAGIKQEmgpknkntifCVSG 871
Cdd:pfam14961  898 IIDGLSVERNHILVRINLIGGPSERILPPRALQKGEDPYPWPMFSSYPLPKCYLPDVPRITDTKQD----------SELS 967

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   872 AMQRSVNNdldklllclkiSDKQTEWIENCQRQFCKMMKAKPDIISGEALIELLEKFVLHLTESPSECYFPSVEYTATDA 951
Cdd:pfam14961  968 KFLSSSKN-----------PEKQAEWMENCRRQFCKIMKTKPDTISGGVLAELLEKFVLHLSESPSECYFSSTEYKAADA 1036

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222   952 NVKNESLSSVQQLGIKMTVRYGKFLSLLKDGAENDLTWVLKHCERFLKQQQTSIKSSLLCLQGNYAGHDWFVSSLFMIML 1031
Cdd:pfam14961 1037 DVKNASLSSVQQLGVKMTIRYGKYLNLLKEDAENDLCLVLKHCEQFLKQQQVKVSSSLRCLQGGYPGHDWFASSVFLIMS 1116

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222  1032 GDKEKTFQFLHQFSRLLTSAFLWLPRLHISSYLPNDTVESGIHPVYFCSTHYIEMLLKAELPLVFSAFHMSGFAPSQICL 1111
Cdd:pfam14961 1117 GDKERSLSFLLRFSHLLVSAFLWPPRLHASIHLPADTAESGIHPVYSCTAHYVEMLLKAEVPLVFSAFRMSGFTPSQICL 1196

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222  1112 QWITQCFWNYLDWIEICHYIATCVFLGPDYQVYICIAVFKHLQQDILQHTQTQDLQVFLKEEALHGFRVSDYFEYMEILE 1191
Cdd:pfam14961 1197 QWLTQCFWNYLDWTEICHYIATCIFMGPDYQVYMCISILKHLQQEILQHTQTQDLQVFLKEEPIHGFRVSNYLEYMESLE 1276

                         1210
                   ....*....|....*.
gi 767942222  1192 QNYRTVLLRDMRNIRL 1207
Cdd:pfam14961 1277 QTYRPMVLTDMRNIRV 1292
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 1022-1158 4.99e-04

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 42.24  E-value: 4.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942222  1022 FVSSLFMIMLGDKEKTFQFlhqFSRLLTsaflwlpRLHISSYLPNDTveSGIHpvyfCSTHYIEMLLKAELPLVFSAFHM 1101
Cdd:pfam00566   57 FIAAPLLLVYLDEEDAFWC---FVSLLE-------NYLLRDFYTPDF--PGLK----RDLYVFEELLKKKLPKLYKHLKE 120

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767942222  1102 SGFAPSQICLQWITQCFWNYLDWIEICHYIATCVFLGPDYQVY-ICIAVFKHLQQDIL 1158
Cdd:pfam00566  121 LGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKFVLFrVALAILKRFREELL 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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