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Conserved domains on  [gi|767970382|ref|XP_011541206|]
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transmembrane protease serine 4 isoform X9 [Homo sapiens]

Protein Classification

LDLa and SRCR_2 domain-containing protein( domain architecture ID 10060221)

LDLa and SRCR_2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRCR_2 super family cl02509
Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain ...
 108-197 1.03e-15

Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.


The actual alignment was detected with superfamily member pfam15494:

Pssm-ID: 470597  Cd Length: 99  Bit Score: 70.44  E-value: 1.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970382  108 KDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQ--------DLDVVEITENSQElrMRNS 179
Cdd:pfam15494   1 GENFLLQVYSSARPSWLPVCSDDWNPAYGRAACQQLGYLRLTHHKSVNLTDISsnssqsfmKLNSSSLNTDLYE--ALQP 78

                          90
                  ....*....|....*...
gi 767970382  180 SGPCLSGSLVSLHCLACG 197
Cdd:pfam15494  79 RDSCSSGSVVSLRCSECG 96
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 58-92 5.30e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 39.50  E-value: 5.30e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 767970382  58 DKYYFLCGQPlHFIPRKQLCDGELDCPLGEDEEHC 92
Cdd:cd00112    2 PPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
SRCR_2 pfam15494
Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain ...
 108-197 1.03e-15

Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.


Pssm-ID: 464747  Cd Length: 99  Bit Score: 70.44  E-value: 1.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970382  108 KDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQ--------DLDVVEITENSQElrMRNS 179
Cdd:pfam15494   1 GENFLLQVYSSARPSWLPVCSDDWNPAYGRAACQQLGYLRLTHHKSVNLTDISsnssqsfmKLNSSSLNTDLYE--ALQP 78

                          90
                  ....*....|....*...
gi 767970382  180 SGPCLSGSLVSLHCLACG 197
Cdd:pfam15494  79 RDSCSSGSVVSLRCSECG 96
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 104-194 3.96e-09

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 52.73  E-value: 3.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970382   104 VRLSKDRS----TLQVLDSatGNWFSACFDNFTEALAETACRQMGYSSKP-TFRAVEIGPDQD---LDVVEI--TENSQE 173
Cdd:smart00202   1 VRLVGGGSpcegRVEVYHN--GQWGTVCDDGWDLRDANVVCRQLGFGGAVsASGSAYFGPGSGpiwLDNVRCsgTEASLS 78

                           90       100
                   ....*....|....*....|...
gi 767970382   174 LRMRNSSG--PCLSGSLVSLHCL 194
Cdd:smart00202  79 DCPHSGWGshNCSHGEDAGVVCS 101
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 58-92 5.30e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 39.50  E-value: 5.30e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 767970382  58 DKYYFLCGQPlHFIPRKQLCDGELDCPLGEDEEHC 92
Cdd:cd00112    2 PPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
71-92 4.06e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 34.15  E-value: 4.06e-03
                          10        20
                  ....*....|....*....|..
gi 767970382   71 IPRKQLCDGELDCPLGEDEEHC 92
Cdd:pfam00057  16 IPRSWVCDGDPDCGDGSDEENC 37
 
Name Accession Description Interval E-value
SRCR_2 pfam15494
Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain ...
 108-197 1.03e-15

Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.


Pssm-ID: 464747  Cd Length: 99  Bit Score: 70.44  E-value: 1.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970382  108 KDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQ--------DLDVVEITENSQElrMRNS 179
Cdd:pfam15494   1 GENFLLQVYSSARPSWLPVCSDDWNPAYGRAACQQLGYLRLTHHKSVNLTDISsnssqsfmKLNSSSLNTDLYE--ALQP 78

                          90
                  ....*....|....*...
gi 767970382  180 SGPCLSGSLVSLHCLACG 197
Cdd:pfam15494  79 RDSCSSGSVVSLRCSECG 96
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 104-194 3.96e-09

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 52.73  E-value: 3.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970382   104 VRLSKDRS----TLQVLDSatGNWFSACFDNFTEALAETACRQMGYSSKP-TFRAVEIGPDQD---LDVVEI--TENSQE 173
Cdd:smart00202   1 VRLVGGGSpcegRVEVYHN--GQWGTVCDDGWDLRDANVVCRQLGFGGAVsASGSAYFGPGSGpiwLDNVRCsgTEASLS 78

                           90       100
                   ....*....|....*....|...
gi 767970382   174 LRMRNSSG--PCLSGSLVSLHCL 194
Cdd:smart00202  79 DCPHSGWGshNCSHGEDAGVVCS 101
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 58-92 5.30e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 39.50  E-value: 5.30e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 767970382  58 DKYYFLCGQPlHFIPRKQLCDGELDCPLGEDEEHC 92
Cdd:cd00112    2 PPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
71-92 4.06e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 34.15  E-value: 4.06e-03
                          10        20
                  ....*....|....*....|..
gi 767970382   71 IPRKQLCDGELDCPLGEDEEHC 92
Cdd:pfam00057  16 IPRSWVCDGDPDCGDGSDEENC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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