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Conserved domains on  [gi|1939001525|ref|XP_012547234|]
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anaphase-promoting complex subunit 4 [Bombyx mori]

Protein Classification

ANAPC4_WD40 and ANAPC4 domain-containing protein( domain architecture ID 10330649)

ANAPC4_WD40 and ANAPC4 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANAPC4 pfam12896
Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of ...
 235-432 7.21e-56

Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Results in C.elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle. the APC/C is likely to be required for all metaphase-to-anaphase transitions in a multicellular organizm.


:

Pssm-ID: 463744  Cd Length: 203  Bit Score: 190.50  E-value: 7.21e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939001525 235 LAIVNTGVLSAYADEINTVAHKHGQIVQLMTQLDQTMISITEAWEHILLEMDTKMAYYASSVHE----GGVSADLLELLM 310
Cdd:pfam12896   2 LLPLDLPFLSSSGRELHLLASKSSQLQSLLRYINQTLKEMQEEWKNARELPDRKLRNLEDLLKEqggeSSIVQELYHLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939001525 311 LGTPSVDLQVYLLEKLTTNDLKKFGNSVELSYSTIQKLVLKQLNIVGQSLVYYLAELRGLTRIEDRYKILGLEESSVTEA 390
Cdd:pfam12896  82 TGHPSPPLKEFLVNQLGERGLKRWEKAVESSYENIRKLVHEHLLPALERLIILLSELRGLAKWHERYEILGLDPELIDEL 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1939001525 391 IKACCAFLNKCLELQQVIDVSMRNYKAFFRWLFVVIVRQLDE 432
Cdd:pfam12896 162 LDTAGSLLLKAHELLQVINEELKLFKAFFRWLRYVIDRLADE 203
ANAPC4_WD40 super family cl14918
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 20-119 1.82e-26

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


The actual alignment was detected with superfamily member pfam12894:

Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 103.51  E-value: 1.82e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939001525  20 MVWSNRLDLLALSNNKGEVQIHRLHWQKVWSLPPPKENGCVQAMAWRPDGKALAIGYNLGIIYTVSVEDKGIIDKYelel 99
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF---- 76

                          90       100
                  ....*....|....*....|
gi 1939001525 100 evtdeldTAKYSGISCIVWA 119
Cdd:pfam12894  77 -------SAGSDLITCLGWG 89
 
Name Accession Description Interval E-value
ANAPC4 pfam12896
Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of ...
 235-432 7.21e-56

Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Results in C.elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle. the APC/C is likely to be required for all metaphase-to-anaphase transitions in a multicellular organizm.


Pssm-ID: 463744  Cd Length: 203  Bit Score: 190.50  E-value: 7.21e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939001525 235 LAIVNTGVLSAYADEINTVAHKHGQIVQLMTQLDQTMISITEAWEHILLEMDTKMAYYASSVHE----GGVSADLLELLM 310
Cdd:pfam12896   2 LLPLDLPFLSSSGRELHLLASKSSQLQSLLRYINQTLKEMQEEWKNARELPDRKLRNLEDLLKEqggeSSIVQELYHLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939001525 311 LGTPSVDLQVYLLEKLTTNDLKKFGNSVELSYSTIQKLVLKQLNIVGQSLVYYLAELRGLTRIEDRYKILGLEESSVTEA 390
Cdd:pfam12896  82 TGHPSPPLKEFLVNQLGERGLKRWEKAVESSYENIRKLVHEHLLPALERLIILLSELRGLAKWHERYEILGLDPELIDEL 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1939001525 391 IKACCAFLNKCLELQQVIDVSMRNYKAFFRWLFVVIVRQLDE 432
Cdd:pfam12896 162 LDTAGSLLLKAHELLQVINEELKLFKAFFRWLRYVIDRLADE 203
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 20-119 1.82e-26

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 103.51  E-value: 1.82e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939001525  20 MVWSNRLDLLALSNNKGEVQIHRLHWQKVWSLPPPKENGCVQAMAWRPDGKALAIGYNLGIIYTVSVEDKGIIDKYelel 99
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF---- 76

                          90       100
                  ....*....|....*....|
gi 1939001525 100 evtdeldTAKYSGISCIVWA 119
Cdd:pfam12894  77 -------SAGSDLITCLGWG 89
 
Name Accession Description Interval E-value
ANAPC4 pfam12896
Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of ...
 235-432 7.21e-56

Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Results in C.elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle. the APC/C is likely to be required for all metaphase-to-anaphase transitions in a multicellular organizm.


Pssm-ID: 463744  Cd Length: 203  Bit Score: 190.50  E-value: 7.21e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939001525 235 LAIVNTGVLSAYADEINTVAHKHGQIVQLMTQLDQTMISITEAWEHILLEMDTKMAYYASSVHE----GGVSADLLELLM 310
Cdd:pfam12896   2 LLPLDLPFLSSSGRELHLLASKSSQLQSLLRYINQTLKEMQEEWKNARELPDRKLRNLEDLLKEqggeSSIVQELYHLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939001525 311 LGTPSVDLQVYLLEKLTTNDLKKFGNSVELSYSTIQKLVLKQLNIVGQSLVYYLAELRGLTRIEDRYKILGLEESSVTEA 390
Cdd:pfam12896  82 TGHPSPPLKEFLVNQLGERGLKRWEKAVESSYENIRKLVHEHLLPALERLIILLSELRGLAKWHERYEILGLDPELIDEL 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1939001525 391 IKACCAFLNKCLELQQVIDVSMRNYKAFFRWLFVVIVRQLDE 432
Cdd:pfam12896 162 LDTAGSLLLKAHELLQVINEELKLFKAFFRWLRYVIDRLADE 203
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 20-119 1.82e-26

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 103.51  E-value: 1.82e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939001525  20 MVWSNRLDLLALSNNKGEVQIHRLHWQKVWSLPPPKENGCVQAMAWRPDGKALAIGYNLGIIYTVSVEDKGIIDKYelel 99
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF---- 76

                          90       100
                  ....*....|....*....|
gi 1939001525 100 evtdeldTAKYSGISCIVWA 119
Cdd:pfam12894  77 -------SAGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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