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Conserved domains on  [gi|971407925|ref|XP_015146148|]
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volume-regulated anion channel subunit LRRC8C isoform X1 [Gallus gallus]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 4-340 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 594.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925    4 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPCQNQSNTSHVISTIPDTTP 83
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925   84 LPPPKPSTPPATVEMKGLKTDLDLQQYSFINQVCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISI 163
Cdd:pfam12534  81 APTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925  164 LGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNV-----SKSNTTQPSTEGTLVKTQSLKSIPEKLVVD-KGTHGALDKK 235
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVlpkvsSSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925  236 EGEQAKALFEKVKKFRLHVEEGDILYVMYVRQTVLKVIKFLIIIAYNTALVSEVNFTVVCNVDIEDMTGYKNFCCNHTMA 315
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 971407925  316 HLFSKLSYCYLCFVSIYGLTCLYTL 340
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
515-774 1.01e-35

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.45  E-value: 1.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 515 LRNLEELYLIGSLSHDISKNITLESFRELKSLKVLYIKSNLSKIPQS--AVDVSSHLQKLCIHNDGTKLVMLNNLKKMVN 592
Cdd:COG4886   18 LELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSllLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 593 LTQLELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTILKLWYNSITYIPEHIKKLTSLERLSFSHN 672
Cdd:COG4886   98 LTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNN 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 673 KIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESVPDELYFCKKLKTLKIGKNNLSVLsPKIGN 752
Cdd:COG4886  170 QLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL-PELGN 248

                        250       260
                 ....*....|....*....|..
gi 971407925 753 LVFLSHLDIKGNHFEILPPELG 774
Cdd:COG4886  249 LTNLEELDLSNNQLTDLPPLAN 270
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 4-340 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 594.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925    4 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPCQNQSNTSHVISTIPDTTP 83
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925   84 LPPPKPSTPPATVEMKGLKTDLDLQQYSFINQVCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISI 163
Cdd:pfam12534  81 APTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925  164 LGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNV-----SKSNTTQPSTEGTLVKTQSLKSIPEKLVVD-KGTHGALDKK 235
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVlpkvsSSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925  236 EGEQAKALFEKVKKFRLHVEEGDILYVMYVRQTVLKVIKFLIIIAYNTALVSEVNFTVVCNVDIEDMTGYKNFCCNHTMA 315
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 971407925  316 HLFSKLSYCYLCFVSIYGLTCLYTL 340
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
515-774 1.01e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.45  E-value: 1.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 515 LRNLEELYLIGSLSHDISKNITLESFRELKSLKVLYIKSNLSKIPQS--AVDVSSHLQKLCIHNDGTKLVMLNNLKKMVN 592
Cdd:COG4886   18 LELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSllLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 593 LTQLELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTILKLWYNSITYIPEHIKKLTSLERLSFSHN 672
Cdd:COG4886   98 LTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNN 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 673 KIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESVPDELYFCKKLKTLKIGKNNLSVLsPKIGN 752
Cdd:COG4886  170 QLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL-PELGN 248

                        250       260
                 ....*....|....*....|..
gi 971407925 753 LVFLSHLDIKGNHFEILPPELG 774
Cdd:COG4886  249 LTNLEELDLSNNQLTDLPPLAN 270
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 435-779 6.54e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.12  E-value: 6.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 435 LSG-LPDTVFEITELQSLKLeIINNVM--IPATIAQLDNLQELSLHQCSVKIHSAALAFLKENLkiLSVKFDDIR---EL 508
Cdd:PLN00113 224 LSGeIPYEIGGLTSLNHLDL-VYNNLTgpIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKL--ISLDLSDNSlsgEI 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 509 PHWMYGLRNLEELYLigsLSHDISKNITlESFRELKSLKVLYIKSN-LS-KIPQSavdvsshlqkLCIHNDGTKL-VMLN 585
Cdd:PLN00113 301 PELVIQLQNLEILHL---FSNNFTGKIP-VALTSLPRLQVLQLWSNkFSgEIPKN----------LGKHNNLTVLdLSTN 366

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 586 NLKKMV--------NLTQLELVHCDLE-RIPHAVFSLLSLQELDLKENNLkSIEEIVSFQHLRKLTILKLWYNSIT-YIP 655
Cdd:PLN00113 367 NLTGEIpeglcssgNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTKLPLVYFLDISNNNLQgRIN 445

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 656 EHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVESV-PDELYFCKKL 733
Cdd:PLN00113 446 SRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGEiPDELSSCKKL 525

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 971407925 734 KTLKIGKNNLSVLSP-KIGNLVFLSHLDIKGNHF--EIlPPELGECRSL 779
Cdd:PLN00113 526 VSLDLSHNQLSGQIPaSFSEMPVLSQLDLSQNQLsgEI-PKNLGNVESL 573
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 592-766 1.00e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.27  E-value: 1.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 592 NLTQLELVHCDLERIPhaVFSLL-SLQELDLKENNLKSIEeivSFQHLRKLTILKLWYNSITYIpEHIKKLTSLERLSFS 670
Cdd:cd21340    3 RITHLYLNDKNITKID--NLSLCkNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 671 HNKIEVLpSHLFLCNKIRYLDLSYNDIrfiPPE----------IGVLQSLQYFSITCNKVESVpDELYFCKKLKTLKIGK 740
Cdd:cd21340   77 GNRISVV-EGLENLTNLEELHIENQRL---PPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASN 151

                        170       180
                 ....*....|....*....|....*....
gi 971407925 741 NNLS---VLSPKIGNLVFLSHLDIKGNHF 766
Cdd:cd21340  152 NQISdleELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
615-674 8.11e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 8.11e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 971407925  615 SLQELDLKENNLKSIEEiVSFQHLRKLTILKLWYNSITYI-PEHIKKLTSLERLSFSHNKI 674
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 4-340 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 594.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925    4 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPCQNQSNTSHVISTIPDTTP 83
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925   84 LPPPKPSTPPATVEMKGLKTDLDLQQYSFINQVCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISI 163
Cdd:pfam12534  81 APTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925  164 LGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNV-----SKSNTTQPSTEGTLVKTQSLKSIPEKLVVD-KGTHGALDKK 235
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVlpkvsSSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925  236 EGEQAKALFEKVKKFRLHVEEGDILYVMYVRQTVLKVIKFLIIIAYNTALVSEVNFTVVCNVDIEDMTGYKNFCCNHTMA 315
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 971407925  316 HLFSKLSYCYLCFVSIYGLTCLYTL 340
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
515-774 1.01e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.45  E-value: 1.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 515 LRNLEELYLIGSLSHDISKNITLESFRELKSLKVLYIKSNLSKIPQS--AVDVSSHLQKLCIHNDGTKLVMLNNLKKMVN 592
Cdd:COG4886   18 LELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSllLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 593 LTQLELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTILKLWYNSITYIPEHIKKLTSLERLSFSHN 672
Cdd:COG4886   98 LTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNN 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 673 KIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESVPDELYFCKKLKTLKIGKNNLSVLsPKIGN 752
Cdd:COG4886  170 QLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL-PELGN 248

                        250       260
                 ....*....|....*....|..
gi 971407925 753 LVFLSHLDIKGNHFEILPPELG 774
Cdd:COG4886  249 LTNLEELDLSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
517-781 1.14e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.59  E-value: 1.14e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 517 NLEELYLIGSLSHDISKNITLESFRELKSLKVLYIKSNLSKIPQSAVDVSSHLQKLCIHNDGTKLVMLNNLKKMVNLTQL 596
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 597 ELVHCDLerIPHAVFSLLSLQELDLKENNlksieeivSFQHLRKLTILKLWYNSITYIPEHIKKLTSLERLSFSHNKIEV 676
Cdd:COG4886   81 LLSLLLL--GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 677 LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESVPDELYFCKKLKTLKIGKNNLSVLSPKIGNLVFL 756
Cdd:COG4886  151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                        250       260
                 ....*....|....*....|....*
gi 971407925 757 SHLDIKGNHFEILpPELGECRSLKR 781
Cdd:COG4886  231 ETLDLSNNQLTDL-PELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-793 1.05e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.71  E-value: 1.05e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 358 QETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTADKLRQRLQTNSHSHLELQLFMLSG 437
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 438 LPDTVFEITELQSLKLEIINNVMIPATIAQLDNLQELSLHQCSvkihsaalaflkenlkilsvkfddIRELPHWMYGLRN 517
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQ------------------------LTDLPEELANLTN 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 518 LEELYLIGSLSHDISknitlESFRELKSLKVLYIKSN-LSKIPQSavdvsshlqklcihndgtklvmlnnLKKMVNLTQL 596
Cdd:COG4886  138 LKELDLSNNQLTDLP-----EPLGNLTNLKSLDLSNNqLTDLPEE-------------------------LGNLTNLKEL 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 597 ELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTILKLWYNSITYIPEhIKKLTSLERLSFSHNKIEV 676
Cdd:COG4886  188 DLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE--PLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTD 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 677 LPSHLFLCNkIRYLDLSYNDIRFIP----PEIGVLQSLQYFSITCNKVESVPDELYFCKKLKTLKIGKNNLSVLSPKIGN 752
Cdd:COG4886  265 LPPLANLTN-LKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 971407925 753 LVFLSHLDIKGNHFEILPPELGECRSLKRTGFTVEDTLFET 793
Cdd:COG4886  344 LSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLAL 384
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 435-779 6.54e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.12  E-value: 6.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 435 LSG-LPDTVFEITELQSLKLeIINNVM--IPATIAQLDNLQELSLHQCSVKIHSAALAFLKENLkiLSVKFDDIR---EL 508
Cdd:PLN00113 224 LSGeIPYEIGGLTSLNHLDL-VYNNLTgpIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKL--ISLDLSDNSlsgEI 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 509 PHWMYGLRNLEELYLigsLSHDISKNITlESFRELKSLKVLYIKSN-LS-KIPQSavdvsshlqkLCIHNDGTKL-VMLN 585
Cdd:PLN00113 301 PELVIQLQNLEILHL---FSNNFTGKIP-VALTSLPRLQVLQLWSNkFSgEIPKN----------LGKHNNLTVLdLSTN 366

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 586 NLKKMV--------NLTQLELVHCDLE-RIPHAVFSLLSLQELDLKENNLkSIEEIVSFQHLRKLTILKLWYNSIT-YIP 655
Cdd:PLN00113 367 NLTGEIpeglcssgNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTKLPLVYFLDISNNNLQgRIN 445

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 656 EHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVESV-PDELYFCKKL 733
Cdd:PLN00113 446 SRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGEiPDELSSCKKL 525

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 971407925 734 KTLKIGKNNLSVLSP-KIGNLVFLSHLDIKGNHF--EIlPPELGECRSL 779
Cdd:PLN00113 526 VSLDLSHNQLSGQIPaSFSEMPVLSQLDLSQNQLsgEI-PKNLGNVESL 573
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
583-773 6.15e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.42  E-value: 6.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 583 MLNNLKKmvNLTQLELVHCDLERIPHAV-----------FSLLSL--------QELDLKENNLKSIEEIVSfqhlRKLTI 643
Cdd:PRK15370 172 MRDCLKN--NKTELRLKILGLTTIPACIpeqittlildnNELKSLpenlqgniKTLYANSNQLTSIPATLP----DTIQE 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 644 LKLWYNSITYIPEHIKklTSLERLSFSHNKIEVLPSHlfLCNKIRYLDLSYNDIRFIPPEIGvlQSLQYFSITCNKVESV 723
Cdd:PRK15370 246 MELSINRITELPERLP--SALQSLDLFHNKISCLPEN--LPEELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTAL 319

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 971407925 724 PDELyfCKKLKTLKIGKNNLSVLSPKIGNLvfLSHLDIKGNHFEILPPEL 773
Cdd:PRK15370 320 PETL--PPGLKTLEAGENALTSLPASLPPE--LQVLDVSKNQITVLPETL 365
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 592-766 1.00e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.27  E-value: 1.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 592 NLTQLELVHCDLERIPhaVFSLL-SLQELDLKENNLKSIEeivSFQHLRKLTILKLWYNSITYIpEHIKKLTSLERLSFS 670
Cdd:cd21340    3 RITHLYLNDKNITKID--NLSLCkNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 671 HNKIEVLpSHLFLCNKIRYLDLSYNDIrfiPPE----------IGVLQSLQYFSITCNKVESVpDELYFCKKLKTLKIGK 740
Cdd:cd21340   77 GNRISVV-EGLENLTNLEELHIENQRL---PPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASN 151

                        170       180
                 ....*....|....*....|....*....
gi 971407925 741 NNLS---VLSPKIGNLVFLSHLDIKGNHF 766
Cdd:cd21340  152 NQISdleELLDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 605-780 9.08e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.56  E-value: 9.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 605 RIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTILKLWYNSIT-YIPEhiKKLTSLERLSFSHNKIE-VLPSHLF 682
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 683 LCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNK-VESVPDELYFCKKLKTLKIGKNNLSVLSPK-IGNLVFLSHL 759
Cdd:PLN00113 162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSGEIPYeIGGLTSLNHL 241

                        170       180
                 ....*....|....*....|..
gi 971407925 760 DIKGNHFE-ILPPELGECRSLK 780
Cdd:PLN00113 242 DLVYNNLTgPIPSSLGNLKNLQ 263
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 515-781 6.63e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.48  E-value: 6.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 515 LRNLEELYLIGS-LSHDISKNITLESfrelkSLKVLYIKSN--LSKIPQSAVDVSShLQKLCIHNDGTKLVMLNNLKKMV 591
Cdd:PLN00113 139 IPNLETLDLSNNmLSGEIPNDIGSFS-----SLKVLDLGGNvlVGKIPNSLTNLTS-LEFLTLASNQLVGQIPRELGQMK 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 592 NLTQLELVHCDLE-RIPHAVFSLLSLQELDLKENNLkSIEEIVSFQHLRKLTILKLWYNSIT-YIPEHIKKLTSLERLSF 669
Cdd:PLN00113 213 SLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNL-TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDL 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 670 SHNKIE-VLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVE-SVPDELYFCKKLKTLKIGKNNLSVL 746
Cdd:PLN00113 292 SDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGE 371

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 971407925 747 SPKI----GNL----VFLSHLDIKgnhfeiLPPELGECRSLKR 781
Cdd:PLN00113 372 IPEGlcssGNLfkliLFSNSLEGE------IPKSLGACRSLRR 408
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 533-689 6.57e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.02  E-value: 6.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 533 KNIT-LESFRELKSLKVLYIKSN-LSKIPQsaVDVSSHLQKLCI-HNDGTKLVMLNNLKKMV----------------NL 593
Cdd:cd21340   12 KNITkIDNLSLCKNLKVLYLYDNkITKIEN--LEFLTNLTHLYLqNNQIEKIENLENLVNLKklylggnrisvvegleNL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 594 TQLELVHCDLERI---------PHAVFSLL-SLQELDLKENNLKSIEEIVSFQHLRKLTILKLWYNSITYIPEHIKKLTS 663
Cdd:cd21340   90 TNLEELHIENQRLppgekltfdPRSLAALSnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSSWPS 169

                        170       180
                 ....*....|....*....|....*.
gi 971407925 664 LERLSFSHNKIevlpshlflCNKIRY 689
Cdd:cd21340  170 LRELDLTGNPV---------CKKPKY 186
LRR_8 pfam13855
Leucine rich repeat;
615-674 8.11e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 8.11e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 971407925  615 SLQELDLKENNLKSIEEiVSFQHLRKLTILKLWYNSITYI-PEHIKKLTSLERLSFSHNKI 674
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
592-651 2.06e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 2.06e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 971407925  592 NLTQLELVHCDLERIPHAVFS-LLSLQELDLKENNLKSIEEiVSFQHLRKLTILKLWYNSI 651
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 584-711 6.80e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 6.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 584 LNNLKKMVNLTQLELVHCDLERIPHAVFSLLSLQELDLKENNL--KSIEEIVS-FQHLRKLTILKLWYNSIT-----YIP 655
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIGdegviALA 257

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 971407925 656 EHIKKLTSLERLSFSHNKIEV-----LPSHLFLCNKIRYLDLSYNDIRFiPPEIGVLQSLQ 711
Cdd:COG5238  258 EALKNNTTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIGD-EGAIALAEGLQ 317
LRR_8 pfam13855
Leucine rich repeat;
708-766 1.53e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.53e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 971407925  708 QSLQYFSITCNKVESVPDE-LYFCKKLKTLKIGKNNLSVLSPK-IGNLVFLSHLDIKGNHF 766
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 606-672 5.08e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 5.08e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 971407925 606 IPHAVFSLLSLQELDLKENNLKSieEI-VSFQHLRKLTILKLWYNSIT-YIPEHIKKLTSLERLSFSHN 672
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRG--NIpPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 615-697 2.30e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 615 SLQELDLKENNLKSIEEIVSFQHLRK---LTILKLWYNSIT-----YIPEHIKKLTSLERLSFSHNKI-----EVLPSHL 681
Cdd:COG5238  293 TLTSLDLSVNRIGDEGAIALAEGLQGnktLHTLNLAYNGIGaqgaiALAKALQENTTLHSLDLSDNQIgdegaIALAKYL 372

                         90
                 ....*....|....*.
gi 971407925 682 FLCNKIRYLDLSYNDI 697
Cdd:COG5238  373 EGNTTLRELNLGKNNI 388
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 471-674 7.94e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 7.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 471 LQELSLHQCSVKIhsAALAFLKENLKilsvkfddirELPHwmyglrNLEELYLIG-SLSHDISKNItLESFRELKSLKVL 549
Cdd:cd00116  110 LQELKLNNNGLGD--RGLRLLAKGLK----------DLPP------ALEKLVLGRnRLEGASCEAL-AKALRANRDLKEL 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 550 yiksnlsKIPQSAVDVSShLQKLCihndgtklvmlNNLKKMVNLTQLELVHCDLER-----IPHAVFSLLSLQELDLKEN 624
Cdd:cd00116  171 -------NLANNGIGDAG-IRALA-----------EGLKANCNLEVLDLNNNGLTDegasaLAETLASLKSLEVLNLGDN 231

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 971407925 625 NLKS--IEEIVS--FQHLRKLTILKLWYNSITY-----IPEHIKKLTSLERLSFSHNKI 674
Cdd:cd00116  232 NLTDagAAALASalLSPNISLLTLSLSCNDITDdgakdLAEVLAEKESLLELDLRGNKF 290
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 616-698 8.18e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 8.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971407925 616 LQELDLKENNLKSIEEIVSFQHL---RKLTILKLWYNSIT-----YIPEHIKKLTSLERLSFSHNKI-----EVLPSHLf 682
Cdd:COG5238  322 LHTLNLAYNGIGAQGAIALAKALqenTTLHSLDLSDNQIGdegaiALAKYLEGNTTLRELNLGKNNIgkqgaEALIDAL- 400

                         90
                 ....*....|....*.
gi 971407925 683 LCNKIRYLDLSYNDIR 698
Cdd:COG5238  401 QTNRLHTLILDGNLIG 416
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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