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Conserved domains on  [gi|992232990|ref|XP_015412579|]
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bicyclomycin resistance protein [Aspergillus nomiae NRRL 13137]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 79-508 3.21e-127

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 376.92  E-value: 3.21e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  79 TLVVAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAG 158
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 159 CAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLA 238
Cdd:cd17323   81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 239 ASGGLVWIMMafavpetyaplllrqraerlsqvtgkvyrskielekgkvalntllrrslsrplvlLFTEPIVLLFAVYIA 318
Cdd:cd17323  161 IISGFCLILI-------------------------------------------------------FLFLPIVLLLGLYVG 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 319 IIYGTLYMFFAGFPIVYEQGRGWNPGVGGLAFLGIMIGMIIGIIFTLPANMHF-IKIQDRLGGFAPPEARLLQCMVGAVA 397
Cdd:cd17323  186 LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYyRRLKKKNGGKPEPEARLPPAFIGAFL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 398 IPISQFWFAWTDYPSIHWIVSIIGTAPFGFGVILIYLGVMNYLIDSYTIYAASVLAANTILRSIFGAVFPLITGYIYDGV 477
Cdd:cd17323  266 FPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                        410       420       430
                 ....*....|....*....|....*....|.
gi 992232990 478 GIHWGPSIPAFLSLLCTPAPFLFYRYGADIR 508
Cdd:cd17323  346 GVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 79-508 3.21e-127

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 376.92  E-value: 3.21e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  79 TLVVAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAG 158
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 159 CAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLA 238
Cdd:cd17323   81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 239 ASGGLVWIMMafavpetyaplllrqraerlsqvtgkvyrskielekgkvalntllrrslsrplvlLFTEPIVLLFAVYIA 318
Cdd:cd17323  161 IISGFCLILI-------------------------------------------------------FLFLPIVLLLGLYVG 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 319 IIYGTLYMFFAGFPIVYEQGRGWNPGVGGLAFLGIMIGMIIGIIFTLPANMHF-IKIQDRLGGFAPPEARLLQCMVGAVA 397
Cdd:cd17323  186 LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYyRRLKKKNGGKPEPEARLPPAFIGAFL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 398 IPISQFWFAWTDYPSIHWIVSIIGTAPFGFGVILIYLGVMNYLIDSYTIYAASVLAANTILRSIFGAVFPLITGYIYDGV 477
Cdd:cd17323  266 FPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                        410       420       430
                 ....*....|....*....|....*....|.
gi 992232990 478 GIHWGPSIPAFLSLLCTPAPFLFYRYGADIR 508
Cdd:cd17323  346 GVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
74-465 1.09e-35

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 136.64  E-value: 1.09e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  74 RKLTITLVVAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMA 153
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 154 AFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWV 233
Cdd:COG2814   87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 234 EGLLAASGGLVWIMMAFAVPETYAPlllrqraerlsqvtgkvyrskielekgkvalntlLRRSLSRPLVLLFTEPIVLLF 313
Cdd:COG2814  167 FLVNAVLALLALLLLLRLLPESRPA----------------------------------ARARLRGSLRELLRRPRLLLL 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 314 AVYIAIIYGTLYMFFAGFPIVYEQGRGWNPGVGGLAFLgimigmiIGIIFTLPANMHFIKIQDRLGgfappeaRLLQCMV 393
Cdd:COG2814  213 LLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA-------LFGLGGVLGALLAGRLADRFG-------RRRLLLI 278

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 992232990 394 GAVAIPISQFWFAWTDypsiHWIVSIIGTAPFGFGVILIYLGVMNYLIDSYTI-YAASVLAANTILRSIFGAV 465
Cdd:COG2814  279 GLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPeARGRASGLYNSAFFLGGPL 347
2_A_01_02 TIGR00880
Multidrug resistance protein;
119-255 2.66e-28

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 109.66  E-value: 2.66e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  119 SLFVLGFAVGPLLWAPISEV----FGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMF 194
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 992232990  195 TARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASGGLVWIMMAFAVPET 255
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_1 pfam07690
Major Facilitator Superfamily;
82-467 9.19e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 111.36  E-value: 9.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990   82 VAFSTMVVALTSSTYSGSVGS-IVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCA 160
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  161 GAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAAS 240
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  241 GGLVWIMMAFAVPETYAPLLLRQRAERLSQVTgkvyrskielekgkvalntllrrslsrPLVLLFTEPIVLLFAVYIAII 320
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIV---------------------------AWKALLRDPVLWLLLALLLFG 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  321 YGTLYMFFAGFpiVYEQGRGWNPGVGGLAFlgimigmIIGIIFTLPANMHFIKIQDRLGgfapPEARLLQCMVGAVAIPI 400
Cdd:pfam07690 214 FAFFGLLTYLP--LYQEVLGLSALLAGLLL-------GLGGLLGAIGRLLLGRLSDRLG----RRRRLLLALLLLILAAL 280

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 992232990  401 SQFWFAWTDYPSIHWIVSIIgtapFGFGVILIYLGVMNYLIDSYTI-YAASVLAANTILRSIFGAVFP 467
Cdd:pfam07690 281 GLLLLSLTLSSLWLLLALLL----LGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGALGP 344
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
102-258 3.41e-19

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 89.59  E-value: 3.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 102 SIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSA 181
Cdd:PRK11102  16 VIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAA 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 992232990 182 PLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASGGLVWIMMAFAVPETYAP 258
Cdd:PRK11102  96 ASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPETLPK 172
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 79-508 3.21e-127

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 376.92  E-value: 3.21e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  79 TLVVAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAG 158
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 159 CAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLA 238
Cdd:cd17323   81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 239 ASGGLVWIMMafavpetyaplllrqraerlsqvtgkvyrskielekgkvalntllrrslsrplvlLFTEPIVLLFAVYIA 318
Cdd:cd17323  161 IISGFCLILI-------------------------------------------------------FLFLPIVLLLGLYVG 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 319 IIYGTLYMFFAGFPIVYEQGRGWNPGVGGLAFLGIMIGMIIGIIFTLPANMHF-IKIQDRLGGFAPPEARLLQCMVGAVA 397
Cdd:cd17323  186 LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYyRRLKKKNGGKPEPEARLPPAFIGAFL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 398 IPISQFWFAWTDYPSIHWIVSIIGTAPFGFGVILIYLGVMNYLIDSYTIYAASVLAANTILRSIFGAVFPLITGYIYDGV 477
Cdd:cd17323  266 FPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                        410       420       430
                 ....*....|....*....|....*....|.
gi 992232990 478 GIHWGPSIPAFLSLLCTPAPFLFYRYGADIR 508
Cdd:cd17323  346 GVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
74-465 1.09e-35

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 136.64  E-value: 1.09e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  74 RKLTITLVVAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMA 153
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 154 AFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWV 233
Cdd:COG2814   87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 234 EGLLAASGGLVWIMMAFAVPETYAPlllrqraerlsqvtgkvyrskielekgkvalntlLRRSLSRPLVLLFTEPIVLLF 313
Cdd:COG2814  167 FLVNAVLALLALLLLLRLLPESRPA----------------------------------ARARLRGSLRELLRRPRLLLL 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 314 AVYIAIIYGTLYMFFAGFPIVYEQGRGWNPGVGGLAFLgimigmiIGIIFTLPANMHFIKIQDRLGgfappeaRLLQCMV 393
Cdd:COG2814  213 LLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA-------LFGLGGVLGALLAGRLADRFG-------RRRLLLI 278

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 992232990 394 GAVAIPISQFWFAWTDypsiHWIVSIIGTAPFGFGVILIYLGVMNYLIDSYTI-YAASVLAANTILRSIFGAV 465
Cdd:COG2814  279 GLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPeARGRASGLYNSAFFLGGPL 347
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 80-493 1.88e-32

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 128.08  E-value: 1.88e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  80 LVVAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGC 159
Cdd:cd17320    2 LLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 160 AGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAA 239
Cdd:cd17320   82 ALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 240 SGGLVWIMMAFAVPETyaplLLRQRAERLSQVTGKVYRSkielekgkvalntllrrslsrplvlLFTEPIVLLFAVYIAI 319
Cdd:cd17320  162 LGLLLLLLVLLFLPET----LPEEKRKPLLSSLLRAYKR-------------------------VLKNRRFLGYALALGL 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 320 IYGTLYMFFAGFPIVYEQGRGWNPGVGGLAFLgimigmiigiiFTLPANMHFIKIQDRLGGFAPPEARLLQCMVGAVAIP 399
Cdd:cd17320  213 SFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFA-----------LNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAA 281

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 400 ISQFWFAWTDYPSIHWIVsiIGTAPFGFGVILIYLGVMNYLIDSYTIYAASVLAANTILRSIFGAVFPLITGYIYDG--V 477
Cdd:cd17320  282 LVLLLAALLGGLSLWPLV--APLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGtaL 359

                        410
                 ....*....|....*.
gi 992232990 478 GIHWGPSIPAFLSLLC 493
Cdd:cd17320  360 PMGLLILVLGLLALLL 375
2_A_01_02 TIGR00880
Multidrug resistance protein;
119-255 2.66e-28

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 109.66  E-value: 2.66e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  119 SLFVLGFAVGPLLWAPISEV----FGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMF 194
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 992232990  195 TARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASGGLVWIMMAFAVPET 255
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 71-351 6.83e-28

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 113.37  E-value: 6.83e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  71 SFARKLTITLVVAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFL 150
Cdd:COG0477    8 PTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 151 VMAAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGW 230
Cdd:COG0477   88 LFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGW 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 231 RWVEgLLAASGGLVWIMMAFAVPETYAPLLLRQRAERLSQVTGKVYRSKIELEKGKVALNTLLRRSLSRPLVLLFTEPIV 310
Cdd:COG0477  168 RWIF-LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALL 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 992232990 311 LLFAVYIAIIYGTLYMFFAGFPIVYEQGRGWNPGVGGLAFL 351
Cdd:COG0477  247 LLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLL 287
MFS_1 pfam07690
Major Facilitator Superfamily;
82-467 9.19e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 111.36  E-value: 9.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990   82 VAFSTMVVALTSSTYSGSVGS-IVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCA 160
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  161 GAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAAS 240
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  241 GGLVWIMMAFAVPETYAPLLLRQRAERLSQVTgkvyrskielekgkvalntllrrslsrPLVLLFTEPIVLLFAVYIAII 320
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIV---------------------------AWKALLRDPVLWLLLALLLFG 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  321 YGTLYMFFAGFpiVYEQGRGWNPGVGGLAFlgimigmIIGIIFTLPANMHFIKIQDRLGgfapPEARLLQCMVGAVAIPI 400
Cdd:pfam07690 214 FAFFGLLTYLP--LYQEVLGLSALLAGLLL-------GLGGLLGAIGRLLLGRLSDRLG----RRRRLLLALLLLILAAL 280

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 992232990  401 SQFWFAWTDYPSIHWIVSIIgtapFGFGVILIYLGVMNYLIDSYTI-YAASVLAANTILRSIFGAVFP 467
Cdd:pfam07690 281 GLLLLSLTLSSLWLLLALLL----LGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGALGP 344
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 82-502 2.87e-23

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 101.50  E-value: 2.87e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  82 VAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAG 161
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 162 AQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASG 241
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 242 GLVWIMMAFAVPETYAPlllrqraerlsqvtgkvyrskielekgkVALNTLLRRSLSRPLVLLFTEPIVLLFAVYIAIIY 321
Cdd:cd17325  161 LLALVLALLLLPEPRPP----------------------------PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLA 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 322 GTLYMFFAGFPIVYEQGRGWNPGVGGLAFLgimigmiIGIIFTLPANMHFIKIQDRLGgfappeaRLLQCMVGAVAIPIS 401
Cdd:cd17325  213 FAFGALEPFLPLYAAELGGLSPAQIGLLFG-------AQGLASALSQPPAGKLSDRIG-------RKPLILIGLLLSAVA 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 402 QFWFAWTDYPSIHWIVSIIgtapFGFGVILIYLGVMNYLIDSYTIYA-ASVLAANTILRSIFGAVFPLITGYIYDGVGIH 480
Cdd:cd17325  279 LLLLPLATSFWLLLLLLAL----LGLGLGLVFPATLALLADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA 354

                        410       420
                 ....*....|....*....|..
gi 992232990 481 WGPSIPAFLSLLCTPApFLFYR 502
Cdd:cd17325  355 TPFLAAAALLLLAAVL-FLLLR 375
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 87-350 2.82e-22

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 99.00  E-value: 2.82e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990   87 MVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIW 166
Cdd:TIGR00710  15 ILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  167 SLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASGGLVWI 246
Cdd:TIGR00710  95 TLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSA 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  247 MMAFAVPETyaplllrqraerlsqvtgKVYRSKIELekGKVALNtllrrslsrpLVLLFTEPIVLLFAVYIAIIYGTLYM 326
Cdd:TIGR00710 175 LIFFILPET------------------LPYEARIQI--STYFET----------FLLLLKSKMFWGYALIYGASFGGFFA 224

                         250       260
                  ....*....|....*....|....
gi 992232990  327 FFAGFPIVYEQGRGWNPGVGGLAF 350
Cdd:TIGR00710 225 FFSGAPFVYIDIMGVSPSVFGLLF 248
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
74-502 8.46e-22

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 97.25  E-value: 8.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  74 RKLTITLVVAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMA 153
Cdd:COG2271    7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 154 AFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWV 233
Cdd:COG2271   87 LATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 234 eGLLAASGGLVWIMMAFavpetyaplllrqraerlsqvtgkvyrskielekgkvalntllrrslsrplvllftepivLLF 313
Cdd:COG2271  167 -FLILGLPGLLLALLRF------------------------------------------------------------WLL 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 314 AVYIAIIYGTLYMFFAGFPIVYEQGRGWNPGVGGLAFLgimigmiIGIIFTLPANMHFIKIQDRLGgfappEARLLQCMV 393
Cdd:COG2271  186 ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLS-------LPFLAGIVGSLLGGWLSDRLG-----RRRKLVLAI 253

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 394 GAVAIPISQFWFAWTDypsiHWIVSIIGTAPFGFGVILIYLGVMNYLIDSY-TIYAASVLAANTILRSIFGAVFPLITGY 472
Cdd:COG2271  254 GLLLAALALLLLALLP----SPALAIALLFLAGFGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGY 329

                        410       420       430
                 ....*....|....*....|....*....|
gi 992232990 473 IYDGVGIHWGPSIPAFLSLLCTPAPFLFYR 502
Cdd:COG2271  330 LLDATGYQAAFLLLAALALLAALLALLLLR 359
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 81-494 1.03e-21

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 96.87  E-value: 1.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  81 VVAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCA 160
Cdd:cd17474    3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 161 GAQNIWSLLILRFFAGaFGSAPLTN-AGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMnAGWRWVEGLLAA 239
Cdd:cd17474   83 LSDSFALLLAGRALQG-IGAAGLGPlALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 240 SGGLVWIMMAFAVPETyaplllrqraerlsqvtgkvyrskielEKGKVALNTLLRRSLSRplvlLFTEPIVLLFAVYIAI 319
Cdd:cd17474  161 LIPVAFLAILFLLPEP---------------------------KEKAKSSSATKLRDLKK----ALRGRGLLTFLVSAFL 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 320 IYGTLYMFFAGFPIVYEQGRGWNPGVGGLAFLGIMIGMIIGIIFTLPanmhfiKIQDRLGGfappeARLLqcMVGAVAIP 399
Cdd:cd17474  210 YFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGR------LLKKRFGA-----RRIL--VIGLLLYA 276

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 400 ISQFWFAWTdyPSIHWIvsIIGTAPFGFGviliyLGVMNYLIDSYTIYAA------SVLAANTILRSIFGAVFPLITGYI 473
Cdd:cd17474  277 LSLLLLGFV--PSLALL--LIAIVLFGLG-----LGLNLPLLTTLVTELApeeergTASSLYNFVRFLGQAVGPLLFGLL 347

                        410       420
                 ....*....|....*....|.
gi 992232990 474 YDGVGIHWgPSIPAFLSLLCT 494
Cdd:cd17474  348 LEIFGLSA-PFLVGAAIALAA 367
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 82-247 2.39e-20

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 93.01  E-value: 2.39e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  82 VAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAG 161
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 162 AQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASG 241
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160


                 ....*.
gi 992232990 242 GLVWIM 247
Cdd:cd17321  161 LVALLL 166
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 79-492 3.69e-20

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 92.23  E-value: 3.69e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  79 TLVVAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAG 158
Cdd:cd17324    1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 159 CAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLA 238
Cdd:cd17324   81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 239 ASGGLVWIMMAFAVPetyaplllrqraerlsqvtgkvyrskielekgKVALNTLLRRSLSRPLVLLFTEPIVLLFAVYIA 318
Cdd:cd17324  161 VLALLAALLLWRLLP--------------------------------SLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITF 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 319 IIYGTLYMFFAGF-PIVYEQGRGWNPGVGGLAFLGIMIGMIigiiftlpANMHFIKIQDRLGGFAPPEARLLQCMVGAVa 397
Cdd:cd17324  209 LLFGGFFALYTYLaPFLTDVPGFSSSAIIGLLLLFGVAGVV--------GSPLAGRLADRGGRRALLIALLLLAAALLL- 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 398 ipisqFWFAWTdypsiHWIVSIIGTAPFGFGVILIYLGVMNYLIDSYTIYAASVLAANTILRSIFGAVFPLITGYIYDGV 477
Cdd:cd17324  280 -----LTLLGP-----SPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHG 349

                        410
                 ....*....|....*
gi 992232990 478 GIHWGPSIPAFLSLL 492
Cdd:cd17324  350 GWAGVGWVGAALLLL 364
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
102-258 3.41e-19

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 89.59  E-value: 3.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 102 SIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSA 181
Cdd:PRK11102  16 VIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAA 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 992232990 182 PLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASGGLVWIMMAFAVPETYAP 258
Cdd:PRK11102  96 ASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPETLPK 172
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 82-478 2.47e-18

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 87.10  E-value: 2.47e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  82 VAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAG 161
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 162 AQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMN--AGWRWVEGLLAA 239
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 240 SGGLVWIMMAFAVPETYAPLLLRQRAERLsqvtgkvyrskielekgkvalntllrRSLSRPLVLLFTEPIVLLFAVYIAI 319
Cdd:cd06174  161 LALLAAILLLLVVPDPPESARAKNEEASS--------------------------KSVLKLLKRVLKNPGLWLLLLAIFL 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 320 IYGTLYMFFAGFPIVYEQGRGWNPGVGGLAFLGIMIGMIIGIIFTLPANMHFIkiqdrlggfappeARLLQCMVGAVAIP 399
Cdd:cd06174  215 VNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI-------------GRKPLLLIGLLLMA 281

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 400 ISQFWFAWTDYPSIHWIVSIIgtapFGFGVILIYLGVMNYLIDSY-TIYAASVLAANTILRSIFGAVFPLITGYIYDGVG 478
Cdd:cd06174  282 LGLALLLLAPSLLLLLLLLLL----LGFGLGGLLPLSFALIAELFpPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 74-332 1.60e-16

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 81.63  E-value: 1.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990   74 RKLTITLVVAFSTMVV-ALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVM 152
Cdd:TIGR00895  13 RYQWRAIILSFLIMLMdGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  153 AAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWR- 231
Cdd:TIGR00895  93 SVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRs 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  232 --WVEGLLAASggLVWIMMaFAVPETYAPLLLRQRAERLSQVTGKVYR-----------SKIELEKGKVALNTLLRRSLS 298
Cdd:TIGR00895 173 lfYVGGIAPLL--LLLLLM-RFLPESIDFLVSKRPETVRRIVNAIAPQmqaeaqsalpeQKSTQGTKRSVFKALFQGKTA 249

                         250       260       270
                  ....*....|....*....|....*....|....
gi 992232990  299 RPLVLLFTEPIVLLFAVYIAIIYGTLYMFFAGFP 332
Cdd:TIGR00895 250 RITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFS 283
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
73-502 1.23e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 78.77  E-value: 1.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  73 ARKLTITLVVAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVM 152
Cdd:COG2223    1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 153 AAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRW 232
Cdd:COG2223   81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 233 VEGLLAASGGLVWIMMAFAVPETyaplllrqraerlsqvtgkvyrSKIELEKGKVALNTLLRrslsrplvlLFTEPIVLL 312
Cdd:COG2223  161 AFLILGILLLVVAVLAWLFLRDP----------------------PAGAAAAAKASLRDQLE---------ALRDPRFWL 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 313 FAVYIAIIYGTLYMFFAGFPIVYEQGRGWNPGVGG-LAFLGIMIGMIIGIIFTLpanmhfikIQDRLGGfappeARLLQC 391
Cdd:COG2223  210 LSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGlLAALFALLGALGRPLGGW--------LSDRIGG-----RRVLLI 276

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 392 MVGAVAIPISQFWFAWTDYPSIHWIVSIIGTA-PFGFGVILIYLGVMNYLIDSYTIYAASVLAANtilrsIFGAVFPLIT 470
Cdd:COG2223  277 VFALMALGLLLLALALGSLWLFLVLFLLLGLAlGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGG-----LGGFLGPLLF 351

                        410       420       430
                 ....*....|....*....|....*....|...
gi 992232990 471 GYIYDGVG-IHWGPSIPAFLSLLCTPAPFLFYR 502
Cdd:COG2223  352 GALLDATGsYTAAFLVFAVLALVALVLTLLLYR 384
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 76-257 1.81e-15

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 78.00  E-value: 1.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  76 LTITLVVAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAF 155
Cdd:cd17319    2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 156 SAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEG 235
Cdd:cd17319   82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161

                        170       180
                 ....*....|....*....|..
gi 992232990 236 LLAASGGLVWIMMAFAVPETYA 257
Cdd:cd17319  162 IEGLLGLLLAVLWWFYLRQVWG 183
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 82-250 2.11e-15

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 78.00  E-value: 2.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  82 VAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAG 161
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 162 AQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASG 241
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160


                 ....*....
gi 992232990 242 GLVWIMMAF 250
Cdd:cd17503  161 ILALLLAPL 169
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
103-256 7.45e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 72.98  E-value: 7.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 103 IVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQR--PFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGS 180
Cdd:COG2271  207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 992232990 181 APLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASGGLVWIMMAFAVPETY 256
Cdd:COG2271  287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 107-244 1.35e-13

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 72.23  E-value: 1.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 107 FDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNA 186
Cdd:cd17365   29 WGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNA 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 992232990 187 GGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEgLLAASGGLV 244
Cdd:cd17365  109 ITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVF-LLGGVPPLI 165
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 76-254 1.60e-13

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 72.80  E-value: 1.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990   76 LTITLVVAfsTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAF 155
Cdd:TIGR00711   3 LTIVLMLG--TFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  156 SAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEG 235
Cdd:TIGR00711  81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160

                         170
                  ....*....|....*....
gi 992232990  236 LLAASGGLVWIMMAFAVPE 254
Cdd:TIGR00711 161 INVPIGIIVVVVAFFILPR 179
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 121-233 2.43e-13

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 71.44  E-value: 2.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 121 FVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRG 200
Cdd:cd17502   39 YLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERG 118

                         90       100       110
                 ....*....|....*....|....*....|...
gi 992232990 201 LALSLYAAAPFLGPALGPIIGGFLSMNAGWRWV 233
Cdd:cd17502  119 KYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWC 151
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 79-247 2.54e-12

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 68.40  E-value: 2.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  79 TLVVAFSTMVVALTSSTYSGSVGSIVTSFD--VSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFS 156
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 157 AGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSM----NAGWRW 232
Cdd:cd17316   81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgDWGWRI 160

                        170
                 ....*....|....*
gi 992232990 233 VEGLLAASGGLVWIM 247
Cdd:cd17316  161 LFLIGALPALLALLL 175
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
76-502 4.16e-12

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 67.98  E-value: 4.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  76 LTITLVVAFSTMVVALTSstYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAF 155
Cdd:COG2807   19 LLLAIVLVALNLRPAITS--VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 156 SAGCAGAQNIWSLLILRFFAG---AFGSAPLTnagGTISDMFtARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRW 232
Cdd:COG2807   97 LLLRSLAPSVALLLAGTALIGagiAVGNVLLP---GLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRG 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 233 ---VEGLLAASGGLVWImmafavpetyaPLLLRQRAERLSQVTGkvyrskielekgkvalntllrrslsRPLVLLFTEPI 309
Cdd:COG2807  173 alaVWALLALLALLLWL-----------PLLRRRPAAAAAAPAA-------------------------ASLRSLWRSPL 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 310 VLLFAVYIAIIYGTLYMFFAGFPIVYEQgRGWNPGVGGLAFlgimigmIIGIIFTLPANMHFIKIQDRLGGFAPPEARLL 389
Cdd:COG2807  217 AWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLL-------SLFQLAGIPGSLLVPLLADRLGDRRPLLLLLG 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 390 QCMVGAVAIpisqFWFAWTDYPsihWIVSIIGTAPFGFGVILIYLGVMNYLiDSYTIYAASVLAANTILrSIFGAVFPLI 469
Cdd:COG2807  289 LLGLAGLLG----LLLAPGSLP---WLWAVLLGLGQGGLFPLALTLIGLRA-RTPAEAAALSGMAQSVG-YLLAALGPLL 359

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 992232990 470 TGYIYDGVGiHWGPSIP--AFLSLLCTPAPFLFYR 502
Cdd:COG2807  360 VGALHDATG-SWTAALLllAALAVLMLVAGLLAGR 393
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
74-492 5.91e-12

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 67.57  E-value: 5.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  74 RKLTITLVVAFstMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMA 153
Cdd:COG0738    7 RRALIAIYLLF--FLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 154 AFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFtARQRGLALSLYAAAPFLGPALGPIIGG-FLSMNAGWRW 232
Cdd:COG0738   85 LGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGlLILLGLSLSW 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 233 VEGLLAASGGLVWIMMAFavpetyaplllrqraerlsqvtgkvYRSKIELEKGKVALNTLLRRSLSRplvlLFTEPIVLL 312
Cdd:COG0738  164 HLPYLILAVLLLLLALLF-------------------------LRSKLPEIEEEEEEAAGSAASLKS----LLKNPRLLL 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 313 FAVYIAIIYGTLYMFFAGFPIVYEQGRGWNPGVGGLAFLGIMIGMIIGIIFTLPANMHFikiqdrlggfapPEARLLQCM 392
Cdd:COG0738  215 GGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF------------GPVRLLRLS 282

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 393 VGAVAIPISQFWFAWtdypsiHWIVSIIGTAPFGFGVILIYLGVMNYLIDSYTIYAASVLAANTILRSIFGAVFPLITGY 472
Cdd:COG0738  283 ALLAAVGLLLALLAP------GPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGF 356

                        410       420
                 ....*....|....*....|
gi 992232990 473 IYDGVGIHWGPSIPAFLSLL 492
Cdd:COG0738  357 LADAFGLRAAFLVPLVCYLL 376
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 95-248 3.98e-11

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 64.95  E-value: 3.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  95 TYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFF 174
Cdd:cd17328   17 TIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 175 AGaFGSAPLTNAGGT-ISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFL-SMNAGWRW---VEGLL-AASGGLVWIMM 248
Cdd:cd17328   97 VG-IGEASYSPIAPTiIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWafrVTGVLgVLLAILLLLFV 175
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 84-248 1.27e-10

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 63.41  E-value: 1.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  84 FSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQ 163
Cdd:cd17475    3 LAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 164 NIWSLLILRFFAGAFGSAplTNAGGT--ISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRW---VEGLLA 238
Cdd:cd17475   83 SYPVLLVLLFLVGAGYGS--VQPGGGraIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAafvVAGLVS 160

                        170
                 ....*....|
gi 992232990 239 ASGGLVWIMM 248
Cdd:cd17475  161 ILAAVLFWLF 170
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 93-479 2.12e-10

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 62.70  E-value: 2.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  93 SSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILR 172
Cdd:cd17371   15 LLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 173 FFAGaFGSAPLTNAGGT-ISDMFTARQRGLALSL----YAAAPFLGPALGPIIGGFLSMNAGWRWVEgLLAASGGLVWIM 247
Cdd:cd17371   95 ALAG-LGFGGEWAAGAAlMAEYVPARHRGKALGYvqsgWAVGWLLATLLAALLFPLLPPEIAWRVLF-LLGALPALLVLF 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 248 MAFAVPETyaPLLLRQRAERLSqvtgkvyrskielEKGKVALNTLLRRSLSRPLVLLFTEPIVLLFAVYIAIIYgtlymf 327
Cdd:cd17371  173 IRRFVKEP--PQWQAARAARRH-------------FADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTW------ 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 328 fagFPIVYEQGRgwnpgvgGLAFLGIMIGMIIGIIFTLPANMHFIKIQDRLGgfAPPEARLLQCMVGAVAIPISQFwfaw 407
Cdd:cd17371  232 ---LPSYLTGER-------GLSFEGSAGYLVVTILGGFLGYLAGGFLADRIG--RRNNFALFALGSAISILLYFFL---- 295

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 992232990 408 TDYPSIHWivsiIGTAPFGFGVILIYLGVMNYLIDSY--TIYAASVLAANTILRSIfGAVFPLITGYIYDGVGI 479
Cdd:cd17371  296 PLSPTLIL----ILGFPLGFFASGPFSGMGAYLTELFptAVRATAQGFCYNVGRII-GALFPFLVGFLATSGSL 364
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
101-255 3.15e-10

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 62.22  E-value: 3.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 101 GSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAgAFGS 180
Cdd:PRK11043  30 KAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQ-AVGV 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 181 ApltNAGGTISDMFTAR------QRGLA--LSLYAaapfLGPALGPIIGGFLSMNAGWRWVEGLLAASgGLVWIMMAFAV 252
Cdd:PRK11043 109 C---SAAVIWQALVIDRypaqkaNRVFAtiMPLVA----LSPALAPLLGAWLLNHFGWQAIFATLFAI-TLLLILPTLRL 180


                 ...
gi 992232990 253 PET 255
Cdd:PRK11043 181 KPS 183
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 82-473 3.26e-09

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 58.74  E-value: 3.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  82 VAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAG 161
Cdd:cd17504    1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 162 AQNIWSLLILRFFAGAfGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVegllaasg 241
Cdd:cd17504   81 APNLPVLIAGRALQGI-GGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWI-------- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 242 glVWIMMAFAVPETYAPLLLRQRaerlsqvtgkvyrskielekgkvalntllrrslsrplvlLFTEPIVLLFAVYIAIIY 321
Cdd:cd17504  152 --FWTAAPVAVLLAALVPLIDLR---------------------------------------LLRRRNVLLANITALLAG 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 322 GTLYMFFAGFPIVYEQGRgwnPGVGGLAFLGIMIGMIIGIIFTLPANMHFIKIQDRLGGFAPPEARLLQCMVGAVAIPIs 401
Cdd:cd17504  191 FGMFMVFQLLPQLLQLPT---PTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLAL- 266

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 992232990 402 qfwfawtdYPSIHWIVSIIGTApFGFGVILIYLGVMNYLIDSYTI-YAASVLAANTILRSIFGAVFPLITGYI 473
Cdd:cd17504  267 --------LHSSLWALVVALLL-IGIGLGLAFASLPNIVVESVPPdRTGIATGMNTVLRTIGSAIGPAIAGAI 330
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 82-258 8.38e-09

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 57.57  E-value: 8.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  82 VAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAG 161
Cdd:cd17477    1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 162 AQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSmNAGWR--WVEGLLAA 239
Cdd:cd17477   81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG-TAGALpfLIAAVLLL 159

                        170
                 ....*....|....*....
gi 992232990 240 SGGLVWIMMAFAVPETYAP 258
Cdd:cd17477  160 LALVPLLLTRRAAPEIEEA 178
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 100-261 9.83e-09

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 57.27  E-value: 9.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 100 VGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFG 179
Cdd:cd17476   21 LPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGP 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 180 SAPLTNAGGTISDMFT-ARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASGGLVWIMMAFAVPETYAP 258
Cdd:cd17476  101 AFLLPNAMALLGRTYPpGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFWTSPSFIA 180


                 ...
gi 992232990 259 LLL 261
Cdd:cd17476  181 VLL 183
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
103-255 2.47e-08

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 56.10  E-value: 2.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 103 IVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRqRP---FFVSFLVMAAFSAgcAGAQNIWSLLILRF------ 173
Cdd:PRK15402  39 VVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGR-RPvmlAGVAFFILTCLAI--LLAQSIEQFTLLRFlqgigl 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 174 -FAGAFGSApltnaggTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASGGLVWIMMAFAV 252
Cdd:PRK15402 116 cFIGAVGYA-------AIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAM 188


                 ...
gi 992232990 253 PET 255
Cdd:PRK15402 189 PET 191
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 102-267 3.70e-08

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 55.79  E-value: 3.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  102 SIVTSFDVSTE---VATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGaF 178
Cdd:TIGR00898 114 TIVTEWDLVCEdawKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVG-M 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  179 GSAPLTNAGGTISDMFTAR-QRGLALSLYAAAPFLGPALGPiigGFLSMNAGWRWVEGLLAASGGLvWIMMAFAVPETYA 257
Cdd:TIGR00898 193 GIGGIWVQAVVLNTEFLPKkQRAIVGTLIQVFFSLGLVLLP---LVAYFIPDWRWLQLAVSLPTFL-FFLLSWFVPESPR 268

                         170
                  ....*....|
gi 992232990  258 PLLLRQRAER 267
Cdd:TIGR00898 269 WLISQGRIEE 278
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 72-246 4.59e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 55.30  E-value: 4.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  72 FARKLTItLVVAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLV 151
Cdd:cd17316  174 LLRRRTL-LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 152 MAAFSA--GCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAG 229
Cdd:cd17316  253 SGILALplFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG 332

                        170       180
                 ....*....|....*....|.
gi 992232990 230 ----WRWVEGLLAASGGLVWI 246
Cdd:cd17316  333 gtgvPALILALLAIVALIVAL 353
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 97-255 6.96e-08

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 54.88  E-value: 6.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  97 SGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAG 176
Cdd:cd17359   21 NGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 177 -AFGSAPlTNAGGTISDMFTARQRGLALSLYAAAPFLGP--------ALGPIIGGFLSMNAGWRWVEGLLAASGGLVWIM 247
Cdd:cd17359  101 lAVGGAS-ALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQllayivnyLIANAGGADWLGAEGWRWMLGLEAIPAILFLLG 179


                 ....*...
gi 992232990 248 MaFAVPET 255
Cdd:cd17359  180 M-LFIPES 186
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
80-252 8.59e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 54.52  E-value: 8.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  80 LVVAFSTMVVALTSSTYSGSVGSIVTS-FDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAG 158
Cdd:COG2211  231 LLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 159 C--AGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDM-------FTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAG 229
Cdd:COG2211  311 LffLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydewkTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390

                        170       180
                 ....*....|....*....|...
gi 992232990 230 wrWVEGLLAASGGLVWIMMAFAV 252
Cdd:COG2211  391 --YVAGAAQSPSALTGIRLLFFL 411
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 113-269 4.07e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.21  E-value: 4.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 113 VATLGLSLFVLGFAVGPL--------LWAP-ISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSAPL 183
Cdd:cd17489   23 AHDLGGSEAVAGLVVGLFtlaallarPFAGrLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFT 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 184 TNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVeGLLAASGGLVWIMMAFAVPETYAPLLLRQ 263
Cdd:cd17489  103 TAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVL-FIVAAVLALLALLLVFLVKDPPPVAAEEA 181


                 ....*.
gi 992232990 264 RAERLS 269
Cdd:cd17489  182 EAGTRA 187
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 113-236 4.27e-07

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 52.27  E-value: 4.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 113 VATLGL--SLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTI 190
Cdd:PRK11551  49 VAQMGWafSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALT 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 992232990 191 SDMFTARQRGLALS-LYAAAPFlGPALGPIIGGFLSMNAGWR---WVEGL 236
Cdd:PRK11551 129 SEAVGPRLRGTAVSlMYCGVPF-GGALASVIGVLAAGDAAWRhifYVGGV 177
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
116-259 5.68e-07

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 51.84  E-value: 5.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 116 LGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSApLTNAGGTISDMFT 195
Cdd:PRK09874  58 LVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGF-VPNANALIATQVP 136

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 992232990 196 ARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASGGLVWIMMAFAVPETYAPL 259
Cdd:PRK09874 137 RNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQPV 200
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 75-255 6.01e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.81  E-value: 6.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  75 KLTITLVVAFSTMVVALTSStysgSVGSIVTSF-DVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMA 153
Cdd:cd17473    1 LITLLLASTLTVMAGAAIAP----ALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 154 AFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSmNAGWRWV 233
Cdd:cd17473   77 IGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAP 155

                        170       180
                 ....*....|....*....|..
gi 992232990 234 eGLLAASGGLVWIMMAFAVPET 255
Cdd:cd17473  156 -FLVYLLALPVLILVLLFLPEP 176
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 74-229 6.17e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.81  E-value: 6.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  74 RKLTITLVVAFSTMVVALTSSTYSGSVgsIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMA 153
Cdd:cd17473  197 KRVLPIYFLAFLAMLLFYVIPIQLPFL--LQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMA 274

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 992232990 154 AFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAG 229
Cdd:cd17473  275 LGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG 350
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 74-243 7.66e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 51.27  E-value: 7.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  74 RKLTITLVVAFSTMVVALTSSTYSGSVgsIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFV-SFLVM 152
Cdd:cd06174  203 PGLWLLLLAIFLVNLAYYSFSTLLPLF--LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLiGLLLM 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 153 AAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFL-SMNAGWR 231
Cdd:cd06174  281 ALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLT 360

                        170
                 ....*....|..
gi 992232990 232 WVEGLLAASGGL 243
Cdd:cd06174  361 GAFLVLAVLLLL 372
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 87-253 1.03e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 51.04  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  87 MVVALTSSTYSGSVGSIVTsfDVSTEVATLGLSLFVLG-----FAVGPLLWAPI----SEVFGRQRPFFVSFLVMAAFSA 157
Cdd:cd17330    2 FLVVFLDALGFGIVFPVLP--FYVREFNKLGASGYYVGllqssYSLGQFLASPLwgrlSDRYGRKPVLLLSLAGSAVSYV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 158 GCAGAQNIWSLLILRFFAGAFGSApLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLL 237
Cdd:cd17330   80 LLGLSRNLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVA 158

                        170
                 ....*....|....*.
gi 992232990 238 AASGGLVWIMMAFAVP 253
Cdd:cd17330  159 AALALLNLVLVLFFLP 174
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 97-257 2.38e-06

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 49.88  E-value: 2.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  97 SGSVGSIVTSFDVSTEVATLGL--SLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFF 174
Cdd:cd17315   17 NGALLYIAKDLGFGLSTSLQGLvvSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 175 AGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNA--GWRWVEGLLAASGGLVWIMMAFaV 252
Cdd:cd17315   97 LGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPpgWWRLMFALAAVPALLQLLLMFF-L 175


                 ....*
gi 992232990 253 PETYA 257
Cdd:cd17315  176 PESRA 180
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 110-255 4.15e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.15  E-value: 4.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 110 STEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGT 189
Cdd:cd17329   33 SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAM 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 992232990 190 ISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMnAGWRWVEGLLAASGGLVWIMMAFAVPET 255
Cdd:cd17329  113 IADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPET 177
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 80-268 4.46e-06

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 49.16  E-value: 4.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  80 LVVAFSTMVVALTSSTYSGSVGSIVTSFDVSTEvATLGLSLFVLGFAVGPLLWAPISEVFGRqRPFFVSFLVMAAF-SAG 158
Cdd:cd06179    1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSN-STWISTAWSLAQAVLGPIVGRLSDLFGR-RWFFIGGNLLGVVgSIV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 159 CAGAQNIWSLLILRFFAGaFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMN--AGWRWVEGL 236
Cdd:cd06179   79 AGTAKSVNMLIGGQALIG-IGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEAnaAGWRWIFYI 157

                        170       180       190
                 ....*....|....*....|....*....|...
gi 992232990 237 LAASGGLVWI-MMAFAVPETYAPLLLRQRAERL 268
Cdd:cd06179  158 NAIFNALALIlLFFFYHPPPRPQLHGSSTRQKL 190
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 113-247 7.88e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 48.34  E-value: 7.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 113 VATLGLSLFVLGF---------AVGPLLWAPISEVFGRQR---PFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGS 180
Cdd:cd17319  207 KQARGFSLKQVGLlaaipflagAIGMILGGRLSDRLLRGArrlVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIG 286

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 992232990 181 APLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFL-----SMNAGWRWVEGLLAASGGLVWIM 247
Cdd:cd17319  287 AASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLvdatgSYTAAFLFLAAVALLAALLVLLL 358
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 81-332 9.34e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 48.04  E-value: 9.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  81 VVAFSTMVVALTSSTYSGSVGS----IVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFS 156
Cdd:cd17355    3 VVLAVTFLILILSWGIRYYFGVfiipIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 157 AGCAGAQNIWSLLILRFFAGAFGSAPLTNAGG-TISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEG 235
Cdd:cd17355   83 VLLALATSLWQLYLLWGLLGGGGAGTLAAVAFaTVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 236 LLAASGGLVwimmafAVPetyAPLLLRQRAERLSQVTGKVyrskielEKGKVALNTLLRRSLSRPLVLLFTEPIVLLFAV 315
Cdd:cd17355  163 VLALLALLV------LVP---VLLLLRRRPADLALRAYDD-------ASPASPGSTLKEALRSASFWLLALAFFLCGFAV 226

                        250
                 ....*....|....*..
gi 992232990 316 YIAIIYGTLYMFFAGFP 332
Cdd:cd17355  227 VGLIVHLVPYLADRGIS 243
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 70-239 1.14e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 47.61  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  70 FSFARKLTITLVVAFSTMVVALTSSTYSGSVGSIV-TSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVS 148
Cdd:cd06173  201 LRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAkEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIG 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 149 FLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNA 228
Cdd:cd06173  281 ALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360

                        170
                 ....*....|.
gi 992232990 229 GWRWVEGLLAA 239
Cdd:cd06173  361 GLSAVFLLAGA 371
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 82-502 1.33e-05

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 47.70  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  82 VAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAG 161
Cdd:cd17333    1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 162 AQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQrGLALSLYAAAPFLGPALGPIIGG-FLSMNAGWRWVeglLAAS 240
Cdd:cd17333   81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESS-ATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWA---YLII 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 241 GGLVWIMMAFAVPETYAPLllrqraerlsqvtgkvyrskielekGKVALNTLLRRSLSRPLVLLFTEPIVLLFAVYIAII 320
Cdd:cd17333  157 GLIYLLLAILILLTLFPEL-------------------------PSARNPQQSVGAFSASASRLLRNPSIILGALALFLY 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 321 YGTLYMFFAGFPIVYEQGRGWNPGVGGLaflgimigmiigiiftLPANMHFIKIQDRLGGfAPPEARLLQ---CMVGAVA 397
Cdd:cd17333  212 VGAETAFSSWVPSYLVEKKHVSDGLAGY----------------LLSGFWVGITIGRLLG-GPISRRIKPhtlLVLSGSG 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 398 IPISQFWFAWTDYPsihwIVSIIGTAPFGFGVILIYLGVMNYLIDSYTIYAASVLAANTILRSIFGAVFPLITGYIYDGV 477
Cdd:cd17333  275 ALLGLLILLLAPTL----VVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAV 350

                        410       420
                 ....*....|....*....|....*
gi 992232990 478 GIhwgPSIPAFLSLLCTpAPFLFYR 502
Cdd:cd17333  351 GI---QTAMLLITILYA-IIFVLAL 371
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 102-327 1.59e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 47.37  E-value: 1.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  102 SIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSA 181
Cdd:TIGR00881  20 YLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGM 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  182 PLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFlSMNAGWRWVEGLLAASG-GLVWIMMAFAV--PETYAP 258
Cdd:TIGR00881 100 GWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLF-GIAELYSWHWVFIVPGIiAIIVSLICFLLlrDSPQSC 178

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 992232990  259 LLLRQRAERLSQVTGKVYRSKIELEKGKVALNTLLrrsLSRPLVLLFTEPIVLLFAVYIAIIYGTLYMF 327
Cdd:TIGR00881 179 GLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVL---LNKVLWYISLGYVFVYVVRTGILDWSPLYLT 244
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 108-255 1.82e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 47.30  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 108 DVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSL-LILRFFAGAFGSAPLTNA 186
Cdd:cd17371  241 GLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLiLILGFPLGFFASGPFSGM 320

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 992232990 187 GGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASGGLVWIMMAFAVPET 255
Cdd:cd17371  321 GAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
113-317 2.64e-05

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 47.27  E-value: 2.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  113 VATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFsagcagaqniwsllilrffagafgsapltnaggtisd 192
Cdd:PRK06814  262 VATLFLAVFSVGVAVGSFLASKLSEGRITLLYVPIGALLMGLF------------------------------------- 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  193 mftarqrGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGL--LAASGGLvWIMMAFAVPETYAPLLLRQRAERLSQ 270
Cdd:PRK06814  305 -------GLDLAFASSSVPAEPAQLKSILVFLSKRHGWRILIDLfgLAAAGGL-YIVPLFAALQAWANPAHRARVIAANN 376

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 992232990  271 VTgkvyrSKIELEKGKVALNTLLRRSLSRPLVLLFTEPIVLLFAVYI 317
Cdd:PRK06814  377 VL-----NAAFMVAGTIILALLQALGFSIPWIILFIALANLIVAILI 418
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 103-258 2.75e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 46.40  E-value: 2.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 103 IVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGaFGSAP 182
Cdd:cd17478   22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAG-IGSAA 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 992232990 183 LTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLsMNAGWRWVEGLLAASGGLVWIMMAFAVPETYAP 258
Cdd:cd17478  101 FHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAAL-VALFGGLGLLILLIIPGLAVALLLLRLRPLKKP 175
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 95-232 2.96e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 46.42  E-value: 2.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  95 TYSGSVGSIVTSFDV---STEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLIL 171
Cdd:cd17317    5 DYSVSESTIVTEWDLvcdRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVL 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 992232990 172 RFFAGaFGSAPLTNAGGTISDMFTA-RQRGLALSLYAAAPFLGPALGPIIGGFLSmnaGWRW 232
Cdd:cd17317   85 RFLVG-VTSAGIFTVGFVLGMEIVGpKYRSFVGILFGLFWALGYMLLALLAYLIR---DWRW 142
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 119-274 3.45e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 46.10  E-value: 3.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 119 SLFVLGFAVGPLlWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFgSAPLTNAGGTISDMFTARQ 198
Cdd:cd17391   44 STFLVSAIFSPI-WGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVF-SGYVPNATALIASQTPKEK 121

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 992232990 199 RGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASGGLVWIMMAFAVPETYAPL---LLRQRAERLSQVTGK 274
Cdd:cd17391  122 SGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVekkKMVSTKEVWNSVPNP 200
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 103-205 4.14e-05

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 45.74  E-value: 4.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 103 IVTSFDVSTEVATL---GLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFG 179
Cdd:cd17374   23 IVTEWDLVCESQSLksvAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAV 102

                         90       100
                 ....*....|....*....|....*.
gi 992232990 180 SAPLTNAGGTISDMFTARQRGLALSL 205
Cdd:cd17374  103 SGISINTLILGTEWTTPRHRALAITL 128
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 111-284 4.32e-05

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 46.20  E-value: 4.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  111 TEVATLGLSLFVLGFAVGPLLWAPISEVFGRqRPFFVSFLVMAAFSA--GCAGAQN---IWSLLILRFFAGAFGSAPLTn 185
Cdd:pfam06609  77 SENQGLFSTLWTMGQAVSILMMGRLTDRFGR-RPFVIATHIIGLVGAivGCTANKFntlLAAMTLLGVAAGPAGASPLF- 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  186 aggtISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGL-LAASGGLVWIMMAFAVPETYAplllrqr 264
Cdd:pfam06609 155 ----IGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIyIIMSAIAVLLIIIWYHPPSFA------- 223

                         170       180
                  ....*....|....*....|
gi 992232990  265 aerlsQVTGKVYRSKIELEK 284
Cdd:pfam06609 224 -----QLHGKKARKRDELAK 238
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 102-244 5.79e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 45.34  E-value: 5.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 102 SIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSA 181
Cdd:cd17312   28 PIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSM 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 992232990 182 PLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEgLLAASGGLV 244
Cdd:cd17312  108 GWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF-LVPGIVGLV 169
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 115-244 6.09e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 45.70  E-value: 6.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 115 TLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSA--PLTNAggTISD 192
Cdd:cd17327   44 NWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGvfPGFIL--YLGM 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 992232990 193 MFTARQRGLALSLYAAAPFLGPALGPIIG-GFLSMN-----AGWRW---VEGLLAASGGLV 244
Cdd:cd17327  122 WYKREEQAKRIAFFYAAAGLGSIFGGLLAyGVFKILgvgglAGWRWlfiIEGLITIIIGLV 182
emrD PRK11652
multidrug transporter EmrD;
78-255 6.72e-05

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 45.28  E-value: 6.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  78 ITLVVAFSTMvvalTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRqRPffVSFLVMAAFSA 157
Cdd:PRK11652  13 LVLLVAVGQM----AQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGR-RP--VILVGMSIFIL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 158 GCAGAQNIWSLLILrfFAGAFGSAPLTNAGGTIS-----DMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRW 232
Cdd:PRK11652  86 GTLVALFAHSLTVL--IAASAIQGLGTGVGGVMArtlprDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRA 163

                        170       180
                 ....*....|....*....|...
gi 992232990 233 VEGLLAASGGLVWIMMAFAVPET 255
Cdd:PRK11652 164 CYLFLLLLGAGVTFSMARWMPET 186
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 109-262 9.13e-05

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 44.91  E-value: 9.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 109 VSTEVATLGLSLFVLG-----FAVGPLLWAPI----SEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFG 179
Cdd:cd17390   19 LSTHIRSLGASPTVIGligsvYGALQLFSSPLvgswSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFK 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 180 SApLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAAS-----GGLVWIMmafaVPE 254
Cdd:cd17390   99 HT-QSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAifilnAGLVWFL----LSK 173


                 ....*...
gi 992232990 255 TYAPLLLR 262
Cdd:cd17390  174 LWDLLLVR 181
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 72-233 9.96e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 44.95  E-value: 9.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  72 FARKLTITLVVAfsTMVVALTSstysGSVGSIVTSFDVSTEVATLGLSLF----VLGFAVGPLLWAP----ISEVFGRQR 143
Cdd:cd17391  198 PNPSLLISLFVT--TFIIQLAN----QSIEPILTLYIRQLMGDASNLAFIsglvFSATGVSSLLSAPrlgkLGDRIGHHR 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 144 PFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGF 223
Cdd:cd17391  272 ILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSA 351

                        170
                 ....*....|
gi 992232990 224 LSMNAGWRWV 233
Cdd:cd17391  352 IAAHFGYRAV 361
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 95-234 1.07e-04

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 44.65  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  95 TYSGSVGSIVTSFDVSTEVA---TLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLIL 171
Cdd:cd17379   13 VYNTPRSSIVTEFNLVCEDAwklDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIF 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 992232990 172 RFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSmnaGWRWVE 234
Cdd:cd17379   93 RFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIP---HWRWLQ 152
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 66-252 1.37e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.12  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  66 NPQLFSFARKLTITLVVAFSTMVVALTSSTYsGSVGSIVTSFDVSTEVATLGLslFVLGFAVGPLLWAPIS-EVFGRQRP 144
Cdd:cd17489  180 EAEAGTRAFRRLVEKKVLPPALILFLASIAY-GAISTFLPLYAAERGISNAGL--FFTVYAIALLLSRPFSgKLSDRKGP 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 145 FFV---SFLVMAAFSAGCAGAQNIWSLLILRFFAGA-FGSapLTNAGGT-ISDMFTARQRGLALSLYAAAPFLGPALGPI 219
Cdd:cd17489  257 KTViipGLLLLALGLLLLSFAGSPWMLLLAAVLYGLgFGL--LFPALQAlAVDLVPPHRRGAANGTFFIFFDLGIGLGGL 334

                        170       180       190
                 ....*....|....*....|....*....|...
gi 992232990 220 IGGFLSMNAGWRWVEGLLAASGGLVWIMMAFAV 252
Cdd:cd17489  335 LLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 110-258 1.42e-04

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 44.16  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 110 STEVATLGLSLFVLgFAVGPLLWAPI----SEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGsAPLTN 185
Cdd:cd17388   33 SADAATHYGVLLAL-YALMQFIFAPIlgalSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITG-ATGAV 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 992232990 186 AGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLsmnAGWRWVEGLLAASG--GLVWIMMAFAVPETYAP 258
Cdd:cd17388  111 AAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLL---GEISPRAPFLVAAGlnGLNFLLGLFVLPESLPP 182
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
65-255 1.48e-04

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 44.43  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  65 RNPQLFS-FARKLTITLVVAFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQR 143
Cdd:PRK15403   3 RMPRFFArHAATLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 144 PFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGF 223
Cdd:PRK15403  83 VLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAA 162

                        170       180       190
                 ....*....|....*....|....*....|..
gi 992232990 224 LSMNAGWRWVEGLLAASGGLVWIMMAFAVPET 255
Cdd:PRK15403 163 LMHFVHWKVLFAIIAVMGLIAFVGLLLAMPET 194
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 119-255 2.12e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 43.80  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 119 SLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAG-AFGSAPLTnAGGTISDMFTAR 197
Cdd:cd17360   42 SSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGlGVGIASMT-VPLYIAEAAPPR 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 992232990 198 QRGLALSLYAAAPFLGPALGPIIGG-FLSMNAGWRWVEGLLAASGGLVWIMMAFaVPET 255
Cdd:cd17360  121 IRGRLVTINVLFITGGQFVAYVINGaFSYLPGGWRWMLGLAAVPAVLQFIGLLF-LPES 178
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 123-253 2.99e-04

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 43.06  E-value: 2.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 123 LGFAVGPLLwAPISEVFGRQRPFFVSFLVMAAFS-AGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGL 201
Cdd:cd06180   45 AGYLVGALL-ASFLRRRGRARRLIRGGLLLTVLLlAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGH 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 992232990 202 ALSLYAAAPFLGPALG-----PIIGGFLSMNAGWRWVEGLLAASGGLVWIMMAFAVP 253
Cdd:cd06180  124 LIGLLFAGVGLGIALSgllvpAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPS 180
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 110-253 3.33e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 42.96  E-value: 3.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 110 STEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCA-GAQNIWSLLILRFFAGAFGSAPLTNAGG 188
Cdd:cd17365  204 SLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGvSPASLVLLYVLVFLAGACVNGAQVGLYA 283

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 992232990 189 TISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFlsmnagwrwvegLLAASGGLVWIMMAFAVP 253
Cdd:cd17365  284 LAARFYPTEVRATGVGWALGVGRLGAILGPLLGGL------------LLAAGLGPESVFLALAIP 336
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 109-252 4.98e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 42.54  E-value: 4.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 109 VSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILrFFAGAFGSAPLTNAGG 188
Cdd:cd17478  227 YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVV 305

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 992232990 189 TISDMFtARQRGLALSLyaaapFLGPALGpiIGGFLSMnagwrwVEGLLAASGGLVWIMMAFAV 252
Cdd:cd17478  306 LAQELL-PGNVGLASGL-----MMGLSFG--LGGIGAP------VLGALADAFGLESVLLILAL 355
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 130-248 5.89e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 42.15  E-value: 5.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 130 LLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSApLTNAGGTISDMFTARQRGLALSLYAAA 209
Cdd:cd17471  253 LLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGI-TAGLGISYFQDLMPGQPGLATTLYSNA 331

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 992232990 210 PFLGPALGPIIGGFLSMNAGWRWVEGLLAASGGLVWIMM 248
Cdd:cd17471  332 SRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLL 370
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 79-268 6.97e-04

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 42.18  E-value: 6.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  79 TLVVAFST----MVVALTSSTYSGSVGSIVTSFDVS-TEVATLGlSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMA 153
Cdd:cd17358    4 TFVANLGSfsfgIAVGWSSPALPSLMSDNSLSLPLTvAQFSWFG-SLLTLGALIGALLSGKLADRIGRKRTLLISAIPCI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 154 AFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSmnagWRWV 233
Cdd:cd17358   83 LGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP----WRTL 158

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 992232990 234 eGLLAASGGLVWIMMAFAVPETYAPLLLRQRAERL 268
Cdd:cd17358  159 -ALIGAIPPVVFLILLFFIPESPRWLAKKGREEEA 192
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 119-264 9.77e-04

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 41.79  E-value: 9.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 119 SLFVLGFAVGPLLWAPISEVFGRQR-------PFFVSFLVMAAfsagcagAQNIWSLLILRFFAG-AFGSAPLTnAGGTI 190
Cdd:cd17433   48 SVVTLGAAAGGVLGGWIVDRAGRKLslmlcsvPFIAGFTVITA-------AQNVWMLYVGRLLTGlASGVTSLV-VPVYI 119

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 992232990 191 SDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSmnagWRWVEGLLAASGGLVWIMMAFaVPETYAPLLLRQR 264
Cdd:cd17433  120 SEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLD----WRWLAVLGSIPPTLMLLLMCF-MPETPRFLLTQHR 188
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
61-251 1.01e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.76  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  61 SNDSRNPQLFSFARKLTITLVVAFSTMVVALTS-STYSGSVGsiVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVF 139
Cdd:COG0738  196 AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAiGDWLPLYL--KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 140 GRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILrFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPI 219
Cdd:COG0738  274 GPVRLLRLSALLAAVGLLLALLAPGPWLALIG-LALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPP 352

                        170       180       190
                 ....*....|....*....|....*....|..
gi 992232990 220 IGGFLSMNAGWRWVEGLLAASGGLVWIMMAFA 251
Cdd:COG0738  353 LIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 118-257 1.22e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 41.39  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 118 LSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLV--MAAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFT 195
Cdd:cd17380   40 LSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALwsLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVP 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 992232990 196 ARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWV---EGLLaasgGLVW-IMMAFAVPETYA 257
Cdd:cd17380  120 VSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVfyfFGLL----GLLWaLVWLIYLPPVWA 181
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 118-257 1.29e-03

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 41.66  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  118 LSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTAR 197
Cdd:pfam05977 260 LGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAAWITALTTLNVAVQLSVPRW 339

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 992232990  198 QRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVegLLAASGGL---VWIMMAFAVPETYA 257
Cdd:pfam05977 340 VRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGA--LLGAAAALlagAAAGLRFRLPEGEA 400
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 82-494 1.82e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 40.68  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  82 VAFSTMVVALTSStysgsvgsivtSFDVSTEVATLGLSLFVLGFAVGPLLwapisEVFGRQRPFFVSFLVMAAFSAGCA- 160
Cdd:cd06173   20 VALPWLVLQLTGS-----------ALLVGLVLAAFFLPFLLFSPFAGVLA-----DRFDRRRLLILADLLRALLAAVLAl 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 161 ----GAQNIWSLLILRFFAGAFGS--APLTNAggTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVE 234
Cdd:cd06173   84 lallGSLSLWLLLVLAFLLGIASAffGPARQA--LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 235 GLLAASGGLVWIMMAFavpetyapllLRQRAERLSQvtgkvyRSKIELEKGKVALNTLLRRSlsrplvllftePIVLLFA 314
Cdd:cd06173  162 AINALSFLLSALLLLF----------IRRPPPAAPG------ESSSLLLRDLREGLRYLRRS-----------PLLRLLL 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 315 VYIAIIYGTLYMFFAGFPIVYEQGRGWNPGVGGLAFLGIMIGMIIGIIFtlpanmhfikiqdrLGGFAPPEARLLQCMVG 394
Cdd:cd06173  215 LALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALL--------------LGRLSKRRRRGRLLLIG 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 395 AVAIPISQFWFAWtdypSIHWIVSIIGTAPFGFGVILIYLgVMNYLIDSYT--IYAASVLAANTILRSIFGAVFPLITGY 472
Cdd:cd06173  281 ALLLGLALLVLGL----SPSLWLLLAALFLLGLAGGLFNV-PLNTLLQLRVpdELRGRVFSVYNALNSGAMPLGALLAGL 355

                        410       420
                 ....*....|....*....|..
gi 992232990 473 IYDGVGIHWGPSIPAFLSLLCT 494
Cdd:cd06173  356 LADALGLSAVFLLAGALLLLAA 377
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 91-255 2.63e-03

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 40.34  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  91 LTSSTYSGSVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLwapiSEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWS--- 167
Cdd:cd17364  223 ISAIGFSKTMNAYQELFNIAVGQLIIALAGTVPGYWFTVFL----IDRIGRKKIQMMGFFGMTIFLLILAGPYDHWKist 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 168 -----LLILRFFAGAFGsaPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASGG 242
Cdd:cd17364  299 igffvLYGLTFFFSNFG--PNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVAL 376

                        170
                 ....*....|...
gi 992232990 243 LVWIMMAFAVPET 255
Cdd:cd17364  377 LGIILTLLFPEEK 389
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 119-255 4.62e-03

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 39.44  E-value: 4.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 119 SLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGaFGSAPLTNAGGTISDMFTARQ 198
Cdd:cd17372   41 SVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVG-LGLGGGPQLASWYLEFLPAKS 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 992232990 199 RGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEgLLAASGGLVWIMMAFAVPET 255
Cdd:cd17372  120 RGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLL-AFSSVPSSLLLVFYRWTPKT 175
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 97-224 5.74e-03

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 39.16  E-value: 5.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  97 SGSVGSIVTSFDVSTEVatlgLSLFVLGFAVGpllwapisevfgRQRPFFVSF--LVMAAFSAGCAGAQniWSLLILRFF 174
Cdd:cd17403   38 STQTGLIASSYDIASVL----LLLFVSYFGGR------------GHKPRWLGIgaFIMGIGSLVFALPH--FTVFILAQL 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 992232990 175 AGAFGSAPLTNAGGTISDMF-TARQRGLALSLYAAAPFLGPALGPIIGGFL 224
Cdd:cd17403  100 LHGAGATPLYTLGVTYLDENvSTKMSPLYIGIFYAMAILGPAIGYVLGGFL 150
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 100-248 6.14e-03

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 39.16  E-value: 6.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 100 VGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCA-GAQNIWSLLILRFFAGaF 178
Cdd:cd17341   22 GPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALAlAVSSYWGLLVLGFLLG-F 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 179 GSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPA----LGPIIGGFLSMNA---GWRWVEG----LLAASGGLVWIM 247
Cdd:cd17341  101 AGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAvsqlLAPLIAGAIVFDGgfvGWRNAFFvpgiLLAIAAVLVLLF 180


                 .
gi 992232990 248 M 248
Cdd:cd17341  181 G 181
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
119-256 6.36e-03

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 39.23  E-value: 6.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 119 SLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGAQNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQ 198
Cdd:PRK10473  45 SVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRR 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 992232990 199 RGLALSLYAAAPFLGPALGPIIGGFLSMNAGWRWVEGLLAASGGLVWIMMAFAVPETY 256
Cdd:PRK10473 125 RAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKETR 182
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 107-249 6.81e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 38.76  E-value: 6.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 107 FDVSTEVATLGLSLFVLGFAVGPLLWAPISE-VFGRQRPFFVSFL--VMAAFSAG---CAGAQNIWSLLILRFFAGAFGS 180
Cdd:cd17475  229 LGLSVVAAGALLAVAQLGGALGRIGLGRVSDrVFGGRRRPVLVITaaIAAAALLVlslLSPGTPLWLLVLLLILLGLFAI 308

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 181 APLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGP-IIGGFLSMNAGWRWVEGLLAASGGLVWIMMA 249
Cdd:cd17475  309 GWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPpLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 74-250 7.73e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 38.66  E-value: 7.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  74 RKLTITLVVAFSTMVVALTSSTYSgsVGSIVTSFDVSTEVATLGLSLFVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMA 153
Cdd:cd17369  228 RALLLAIGLRLAENVLFYLFTTFA--LSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAA 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 154 AFSA---GCAGAQNIWSLLILRFFAGAFGSAPLTNAGGT-ISDMFTARQR--GLALSlYAAAPFLGPALGPIIG-GFLSM 226
Cdd:cd17369  306 LFAFpffWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAfLAELFPTRVRytGASLG-YQLGAILGGGFAPLIAtALVAA 384

                        170       180
                 ....*....|....*....|....
gi 992232990 227 NAGWRWVEGLLAASGGLVWIMMAF 250
Cdd:cd17369  385 TGSWWPVALYLAALAVISLVAALF 408
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 83-250 8.91e-03

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 38.49  E-value: 8.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990  83 AFSTMVVALTSSTYSGSVGSIVTSFDVSTEVATLglslfVLGFAVGPLLWAPISEVFGRQRPFFVSFLVMAAFSAGCAGA 162
Cdd:cd17362   15 ATSGALLSITSPALSGTDWYNLSSLQSGLVVSGS-----LLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992232990 163 QNIWSLLILRFFAGAFGSAPLTNAGGTISDMFTARQRGLALSLYAAAPFLGPALGPIIG-GFLSMNAGWRWVEGLLAASG 241
Cdd:cd17362   90 PSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGyAFADVVGGWRYMYGLAAPPA 169


                 ....*....
gi 992232990 242 GLVWIMMAF 250
Cdd:cd17362  170 LLLGIGMWF 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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