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Conserved domains on  [gi|1034654253|ref|XP_016867266|]
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methyltransferase-like protein 27 isoform X1 [Homo sapiens]

Protein Classification

class I SAM-dependent DNA methyltransferase( domain architecture ID 11471966)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047
PubMed:  23180741|12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
32-224 8.41e-28

Predicted methyltransferase, contains TPR repeat [General function prediction only];


:

Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 105.08  E-value: 8.41e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  32 YDRWAPDYDQD-VATLLYRAPRLAVDCLTQALPGPPhSALILDVACGTGLVAAELRAPGFlQLHGVDGSPGMLEQAQAPG 110
Cdd:COG4976    11 FDQYADSYDAAlVEDLGYEAPALLAEELLARLPPGP-FGRVLDLGCGTGLLGEALRPRGY-RLTGVDLSEEMLAKAREKG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253 111 LYQRLSLCTLGQepLPSPEGTFDAVLIVGALSDGQVPCNAIPELHvtkpgttipsrdgpglwllplPHLTypspPGGLVC 190
Cdd:COG4976    89 VYDRLLVADLAD--LAEPDGRFDLIVAADVLTYLGDLAAVFAGVA---------------------RALK----PGGLFI 141

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1034654253 191 LTTRTNSSNLQYKEALEATLDRLEQAGMW-EGLVA 224
Cdd:COG4976   142 FSVEDADGSGRYAHSLDYVRDLLAAAGFEvPGLLV 176
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
32-224 8.41e-28

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 105.08  E-value: 8.41e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  32 YDRWAPDYDQD-VATLLYRAPRLAVDCLTQALPGPPhSALILDVACGTGLVAAELRAPGFlQLHGVDGSPGMLEQAQAPG 110
Cdd:COG4976    11 FDQYADSYDAAlVEDLGYEAPALLAEELLARLPPGP-FGRVLDLGCGTGLLGEALRPRGY-RLTGVDLSEEMLAKAREKG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253 111 LYQRLSLCTLGQepLPSPEGTFDAVLIVGALSDGQVPCNAIPELHvtkpgttipsrdgpglwllplPHLTypspPGGLVC 190
Cdd:COG4976    89 VYDRLLVADLAD--LAEPDGRFDLIVAADVLTYLGDLAAVFAGVA---------------------RALK----PGGLFI 141

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1034654253 191 LTTRTNSSNLQYKEALEATLDRLEQAGMW-EGLVA 224
Cdd:COG4976   142 FSVEDADGSGRYAHSLDYVRDLLAAAGFEvPGLLV 176
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 71-160 6.69e-16

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 71.06  E-value: 6.69e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  71 ILDVACGTGLVAAELRAPGFLQLHGVDGSPGMLEQAQ--APGLYQRLSLCTLGQEPLPSPEGTFDAVLIVGAL---SDGQ 145
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARerAAEAGLNVEFVQGDAEDLPFPDGSFDLVVSSGVLhhlPDPD 80

                          90
                  ....*....|....*.
gi 1034654253 146 VPcNAIPELH-VTKPG 160
Cdd:pfam13649  81 LE-AALREIArVLKPG 95
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 30-160 7.81e-10

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 57.66  E-value: 7.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  30 HFYDRWAPDYDQ--DVATL----LYRapRLAVDCltqALPGPPHSalILDVACGTGLVAAEL--RAPGFLQLHGVDGSPG 101
Cdd:TIGR01934   3 EMFDRIAPKYDLlnDLLSFglhrLWR--RRAVKL---IGVFKGQK--VLDVACGTGDLAIELakSAPDRGKVTGVDFSSE 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034654253 102 MLEQAQAP-GLYQRLSLCTLGQEPLPSPEGTFDAVLIVGALSDGQVPCNAIPELH-VTKPG 160
Cdd:TIGR01934  76 MLEVAKKKsELPLNIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYrVLKPG 136
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 33-160 7.36e-09

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 54.77  E-value: 7.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  33 DRWAPDYDQ--DVATL----LYRapRLAVDCLtqalpGPPHSALILDVACGTGLVAAEL--RAPGFLQLHGVDGSPGMLE 104
Cdd:PRK00216   18 DSIAPKYDLmnDLLSFglhrVWR--RKTIKWL-----GVRPGDKVLDLACGTGDLAIALakAVGKTGEVVGLDFSEGMLA 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034654253 105 QAQ----APGLYQRLSLCTLGQEPLPSPEGTFDAVLIvgA-----LSDGQVpcnAIPELH-VTKPG 160
Cdd:PRK00216   91 VGReklrDLGLSGNVEFVQGDAEALPFPDNSFDAVTI--AfglrnVPDIDK---ALREMYrVLKPG 151
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 71-142 1.74e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 48.58  E-value: 1.74e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034654253  71 ILDVACGTGLVAAELRAPGFLQLHGVDGSPGMLEQAQAPGLYQRLSLCTLGQ----EPLPSPEGTFDAVLIVGALS 142
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKgdaeELPPEADESFDVIISDPPLH 77
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
32-224 8.41e-28

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 105.08  E-value: 8.41e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  32 YDRWAPDYDQD-VATLLYRAPRLAVDCLTQALPGPPhSALILDVACGTGLVAAELRAPGFlQLHGVDGSPGMLEQAQAPG 110
Cdd:COG4976    11 FDQYADSYDAAlVEDLGYEAPALLAEELLARLPPGP-FGRVLDLGCGTGLLGEALRPRGY-RLTGVDLSEEMLAKAREKG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253 111 LYQRLSLCTLGQepLPSPEGTFDAVLIVGALSDGQVPCNAIPELHvtkpgttipsrdgpglwllplPHLTypspPGGLVC 190
Cdd:COG4976    89 VYDRLLVADLAD--LAEPDGRFDLIVAADVLTYLGDLAAVFAGVA---------------------RALK----PGGLFI 141

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1034654253 191 LTTRTNSSNLQYKEALEATLDRLEQAGMW-EGLVA 224
Cdd:COG4976   142 FSVEDADGSGRYAHSLDYVRDLLAAAGFEvPGLLV 176
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 32-160 2.51e-16

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 73.87  E-value: 2.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  32 YDRWAPDYDQDVATLlyraprlavdcltQALPGPPHSAlILDVACGTGLVAAELRAPGFlQLHGVDGSPGMLEQAQ--AP 109
Cdd:COG2226     1 FDRVAARYDGREALL-------------AALGLRPGAR-VLDLGCGTGRLALALAERGA-RVTGVDISPEMLELARerAA 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034654253 110 GLYQRLSLCTLGQEPLPSPEGTFDAVLIVGALSDGQVPCNAIPELH-VTKPG 160
Cdd:COG2226    66 EAGLNVEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIArVLKPG 117
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 71-160 6.69e-16

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 71.06  E-value: 6.69e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  71 ILDVACGTGLVAAELRAPGFLQLHGVDGSPGMLEQAQ--APGLYQRLSLCTLGQEPLPSPEGTFDAVLIVGAL---SDGQ 145
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARerAAEAGLNVEFVQGDAEDLPFPDGSFDLVVSSGVLhhlPDPD 80

                          90
                  ....*....|....*.
gi 1034654253 146 VPcNAIPELH-VTKPG 160
Cdd:pfam13649  81 LE-AALREIArVLKPG 95
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 48-143 3.50e-11

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 61.09  E-value: 3.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  48 YRAPRLAVDCLTQALPGPPHSALILDVACGTGLVAAELRAPGFLQLHGVDGSPGMLEQAQApgLYQRLSLCTL------G 121
Cdd:COG0500     7 SDELLPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARA--RAAKAGLGNVeflvadL 84

                          90       100
                  ....*....|....*....|..
gi 1034654253 122 QEPLPSPEGTFDAVLIVGALSD 143
Cdd:COG0500    85 AELDPLPAESFDLVVAFGVLHH 106
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 72-160 9.04e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 57.29  E-value: 9.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  72 LDVACGTGLVAAELRAPGFlQLHGVDGSPGMLEQAQAPGLYQRLSLCTLGQEPLPSPEGTFDAVLIVGALSDGQVPCNAI 151
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA-RVTGVDISPEMLELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERAL 79

                          90
                  ....*....|
gi 1034654253 152 PELH-VTKPG 160
Cdd:pfam08241  80 REIArVLKPG 89
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 71-141 9.97e-11

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 58.11  E-value: 9.97e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034654253  71 ILDVACGTGLVAAELRAPGFlQLHGVDGSPGMLEQAQAPGLYQRLSLCTLGQEPLPSPEGTFDAVLIVGAL 141
Cdd:COG2227    28 VLDVGCGTGRLALALARRGA-DVTGVDISPEALEIARERAAELNVDFVQGDLEDLPLEDGSFDLVICSEVL 97
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 30-160 7.81e-10

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 57.66  E-value: 7.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  30 HFYDRWAPDYDQ--DVATL----LYRapRLAVDCltqALPGPPHSalILDVACGTGLVAAEL--RAPGFLQLHGVDGSPG 101
Cdd:TIGR01934   3 EMFDRIAPKYDLlnDLLSFglhrLWR--RRAVKL---IGVFKGQK--VLDVACGTGDLAIELakSAPDRGKVTGVDFSSE 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034654253 102 MLEQAQAP-GLYQRLSLCTLGQEPLPSPEGTFDAVLIVGALSDGQVPCNAIPELH-VTKPG 160
Cdd:TIGR01934  76 MLEVAKKKsELPLNIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYrVLKPG 136
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
71-141 3.16e-09

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 53.29  E-value: 3.16e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034654253  71 ILDVACGTGLVAAEL--RAPGFlQLHGVDGSPGMLEQAQA--PGL-YQRLSLCTLgqeplpSPEGTFDAVLIVGAL 141
Cdd:COG4106     5 VLDLGCGTGRLTALLaeRFPGA-RVTGVDLSPEMLARARArlPNVrFVVADLRDL------DPPEPFDLVVSNAAL 73
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 33-160 7.36e-09

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 54.77  E-value: 7.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  33 DRWAPDYDQ--DVATL----LYRapRLAVDCLtqalpGPPHSALILDVACGTGLVAAEL--RAPGFLQLHGVDGSPGMLE 104
Cdd:PRK00216   18 DSIAPKYDLmnDLLSFglhrVWR--RKTIKWL-----GVRPGDKVLDLACGTGDLAIALakAVGKTGEVVGLDFSEGMLA 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034654253 105 QAQ----APGLYQRLSLCTLGQEPLPSPEGTFDAVLIvgA-----LSDGQVpcnAIPELH-VTKPG 160
Cdd:PRK00216   91 VGReklrDLGLSGNVEFVQGDAEALPFPDNSFDAVTI--AfglrnVPDIDK---ALREMYrVLKPG 151
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 71-142 1.74e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 48.58  E-value: 1.74e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034654253  71 ILDVACGTGLVAAELRAPGFLQLHGVDGSPGMLEQAQAPGLYQRLSLCTLGQ----EPLPSPEGTFDAVLIVGALS 142
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKgdaeELPPEADESFDVIISDPPLH 77
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 72-142 3.25e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 47.36  E-value: 3.25e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034654253  72 LDVACGTGLVAAELRA-PGFLQLHGVDGSPGMLEQAQ---APGLYQRLSLCTLGQEPLPSPEG-TFDAVLIVGALS 142
Cdd:pfam08242   1 LEIGCGTGTLLRALLEaLPGLEYTGLDISPAALEAARerlAALGLLNAVRVELFQLDLGELDPgSFDVVVASNVLH 76
PRK08317 PRK08317
hypothetical protein; Provisional
 71-160 3.84e-07

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 49.94  E-value: 3.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  71 ILDVACGTGLVAAELRA---PGFLqLHGVDGSPGMLEQAQAPGLYQRLSLCTL---GQEpLPSPEGTFDAVLIVGALSDG 144
Cdd:PRK08317   23 VLDVGCGPGNDARELARrvgPEGR-VVGIDRSEAMLALAKERAAGLGPNVEFVrgdADG-LPFPDGSFDAVRSDRVLQHL 100

                          90
                  ....*....|....*..
gi 1034654253 145 QVPCNAIPELH-VTKPG 160
Cdd:PRK08317  101 EDPARALAEIArVLRPG 117
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
30-137 2.32e-05

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 44.35  E-value: 2.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  30 HFYDRWAPDYDQDVATLLYRAPRLAVDcLTQALPGPPHSALILDVACGTGLVAAEL----RAPGflQLHGVDGSPGMLEQ 105
Cdd:pfam01209   6 DVFSSVASKYDLMNDVISFGIHRLWKD-FTMKCMGVKRGNKFLDVAGGTGDWTFGLsdsaGSSG--KVVGLDINENMLKE 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1034654253 106 AQAP----GLYQRLSLCTLGQEpLPSPEGTFDAVLI 137
Cdd:pfam01209  83 GEKKakeeGKYNIEFLQGNAEE-LPFEDDSFDIVTI 117
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 46-209 3.71e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 43.19  E-value: 3.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  46 LLYRAPRLAVDCLTQALPGPPHSALILDVACGTGLVAAELRAPGFlQLHGVDGSPGMLEqaqaPGLYQRLSLCTLGQEPL 125
Cdd:pfam13489   1 YAHQRERLLADLLLRLLPKLPSPGRVLDFGCGTGIFLRLLRAQGF-SVTGVDPSPIAIE----RALLNVRFDQFDEQEAA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253 126 PsPEGTFDAVLIVGALSDGQVPCNAIPELH-VTKPGTTI----PSRDGPglWLLPLPHLTYPSPPGGLVCLTTRTNssnl 200
Cdd:pfam13489  76 V-PAGKFDVIVAREVLEHVPDPPALLRQIAaLLKPGGLLllstPLASDE--ADRLLLEWPYLRPRNGHISLFSARS---- 148


                  ....*....
gi 1034654253 201 qYKEALEAT 209
Cdd:pfam13489 149 -LKRLLEEA 156
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 12-135 5.16e-05

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 43.29  E-value: 5.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  12 VRARVRAAHgipdlaqklhfydrwapdyDQDVATLLYRAPRLavdcltqalpGPPHSALILDVACGTGLVAAELRAPGFl 91
Cdd:PRK07580   37 VRATVRAGH-------------------QRMRDTVLSWLPAD----------GDLTGLRILDAGCGVGSLSIPLARRGA- 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1034654253  92 QLHGVDGSPGMLEQAQ--AP--GLYQRLSLCTLGQEPLpspEGTFDAV 135
Cdd:PRK07580   87 KVVASDISPQMVEEARerAPeaGLAGNITFEVGDLESL---LGRFDTV 131
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 39-141 1.12e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 41.45  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  39 YDQDVATLLYRAPRLAVDCLTQALPGPPHSAlILDVACGTGLVAAEL-RAPGFlQLHGVDGSPGMLEQAQA----PGLYQ 113
Cdd:COG2230    24 YFEDPDDTLEEAQEAKLDLILRKLGLKPGMR-VLDIGCGWGGLALYLaRRYGV-RVTGVTLSPEQLEYAREraaeAGLAD 101

                          90       100
                  ....*....|....*....|....*...
gi 1034654253 114 RLSLCTLGQEPLPsPEGTFDAVLIVGAL 141
Cdd:COG2230   102 RVEVRLADYRDLP-ADGQFDAIVSIGMF 128
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 52-163 8.46e-04

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 39.74  E-value: 8.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  52 RLAVDCLTQALPGPPHSAlILDVACGTGLVAAELRAPGfLQLHGVDGSPGMLEQAQAPGLYQRLSLCTLgqEPLPSPEGT 131
Cdd:PRK10258   28 RQSADALLAMLPQRKFTH-VLDAGCGPGWMSRYWRERG-SQVTALDLSPPMLAQARQKDAADHYLAGDI--ESLPLATAT 103

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1034654253 132 FD------AVLIVGALSDgqvpcnAIPELH-VTKPGTTI 163
Cdd:PRK10258  104 FDlawsnlAVQWCGNLST------ALRELYrVVRPGGVV 136
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 64-160 3.83e-03

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 37.65  E-value: 3.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  64 GPPHSALILDVACGTGLVAAELRAPgFLQLH--GVDGSPGMLEQAQAPGLYQRLSLCtlGQ-EPLPSPEGTFDavLIVGA 140
Cdd:TIGR02072  31 GIFIPASVLDIGCGTGYLTRALLKR-FPQAEfiALDISAGMLAQAKTKLSENVQFIC--GDaEKLPLEDSSFD--LIVSN 105

                          90       100
                  ....*....|....*....|....*.
gi 1034654253 141 LS-----DgqvPCNAIPELH-VTKPG 160
Cdd:TIGR02072 106 LAlqwcdD---LSQALSELArVLKPG 128
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 71-175 9.87e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 35.86  E-value: 9.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654253  71 ILDVACGTG----LVAAELRAPGflQLHGVDGSPGMLEQAQ---APGLYQRLSLCT--LGQEPLPSPEGTFDAVLIVGAL 141
Cdd:pfam13847   7 VLDLGCGTGhlsfELAEELGPNA--EVVGIDISEEAIEKARenaQKLGFDNVEFEQgdIEELPELLEDDKFDVVISNCVL 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1034654253 142 SDGQVPCNAIPELH-VTKPGTTIPSRDGPGLWLLP 175
Cdd:pfam13847  85 NHIPDPDKVLQEILrVLKPGGRLIISDPDSLAELP 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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