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Conserved domains on  [gi|1034654605|ref|XP_016867360|]
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protein ITPRID1 isoform X1 [Homo sapiens]

Protein Classification

KRAP_IP3R_bind and SSFA2_C domain-containing protein( domain architecture ID 10631615)

KRAP_IP3R_bind and SSFA2_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAP_IP3R_bind pfam14722
Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the ...
 114-258 1.99e-95

Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localization of IP3R is crucial for its proper function.


:

Pssm-ID: 464280  Cd Length: 145  Bit Score: 298.48  E-value: 1.99e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654605  114 LSRGTSFNSCYSTASVPQSIPEWLEFWEIDPVEILLDLGFGADEPDICMQIPARFLGCGSAARGINIRVFLEAQKQRMDI 193
Cdd:pfam14722    1 LSRGTSFNSSHSTASTPQSISEWLEFWEEDPEEILLDLGFGADEPDICTRIPARFLGCPSAARGINIRVFLEAQKQRMDI 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034654605  194 ENPNLYGRFRQLEILDHVTNAFSSLLSDVSILPNRAEEKAGGESVQRTSVSAAKEHRRRMGKLLR 258
Cdd:pfam14722   81 ENPNLASRFRQLEVLDHVANAFSSLYSDVSITPVQAEEKSVGSEPQSPSVSETKEHRRRMGKLLS 145
SSFA2_C super family cl20656
Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the ...
 846-931 1.83e-06

Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2.


The actual alignment was detected with superfamily member pfam14723:

Pssm-ID: 464281  Cd Length: 171  Bit Score: 49.14  E-value: 1.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654605  846 TTLKALQDTTVRELCSCTVHEMEAMKTICQSFREYLEEIEQHLMGQQALFSRDMSEEEREEAEQLQTLREALRQQVAELE 925
Cdd:pfam14723   78 ASGYNTQRSSVLPLYENTFQELQVMRRSLNLFRTQMMDLELSMLRQQTMVYQHLTEEERYEADQLQSLRNSVRMELQELE 157


                   ....*.
gi 1034654605  926 FQLGDR 931
Cdd:pfam14723  158 LQLEDR 163
 
Name Accession Description Interval E-value
KRAP_IP3R_bind pfam14722
Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the ...
 114-258 1.99e-95

Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localization of IP3R is crucial for its proper function.


Pssm-ID: 464280  Cd Length: 145  Bit Score: 298.48  E-value: 1.99e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654605  114 LSRGTSFNSCYSTASVPQSIPEWLEFWEIDPVEILLDLGFGADEPDICMQIPARFLGCGSAARGINIRVFLEAQKQRMDI 193
Cdd:pfam14722    1 LSRGTSFNSSHSTASTPQSISEWLEFWEEDPEEILLDLGFGADEPDICTRIPARFLGCPSAARGINIRVFLEAQKQRMDI 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034654605  194 ENPNLYGRFRQLEILDHVTNAFSSLLSDVSILPNRAEEKAGGESVQRTSVSAAKEHRRRMGKLLR 258
Cdd:pfam14722   81 ENPNLASRFRQLEVLDHVANAFSSLYSDVSITPVQAEEKSVGSEPQSPSVSETKEHRRRMGKLLS 145
SSFA2_C pfam14723
Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the ...
 846-931 1.83e-06

Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2.


Pssm-ID: 464281  Cd Length: 171  Bit Score: 49.14  E-value: 1.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654605  846 TTLKALQDTTVRELCSCTVHEMEAMKTICQSFREYLEEIEQHLMGQQALFSRDMSEEEREEAEQLQTLREALRQQVAELE 925
Cdd:pfam14723   78 ASGYNTQRSSVLPLYENTFQELQVMRRSLNLFRTQMMDLELSMLRQQTMVYQHLTEEERYEADQLQSLRNSVRMELQELE 157


                   ....*.
gi 1034654605  926 FQLGDR 931
Cdd:pfam14723  158 LQLEDR 163
 
Name Accession Description Interval E-value
KRAP_IP3R_bind pfam14722
Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the ...
 114-258 1.99e-95

Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localization of IP3R is crucial for its proper function.


Pssm-ID: 464280  Cd Length: 145  Bit Score: 298.48  E-value: 1.99e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654605  114 LSRGTSFNSCYSTASVPQSIPEWLEFWEIDPVEILLDLGFGADEPDICMQIPARFLGCGSAARGINIRVFLEAQKQRMDI 193
Cdd:pfam14722    1 LSRGTSFNSSHSTASTPQSISEWLEFWEEDPEEILLDLGFGADEPDICTRIPARFLGCPSAARGINIRVFLEAQKQRMDI 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034654605  194 ENPNLYGRFRQLEILDHVTNAFSSLLSDVSILPNRAEEKAGGESVQRTSVSAAKEHRRRMGKLLR 258
Cdd:pfam14722   81 ENPNLASRFRQLEVLDHVANAFSSLYSDVSITPVQAEEKSVGSEPQSPSVSETKEHRRRMGKLLS 145
SSFA2_C pfam14723
Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the ...
 846-931 1.83e-06

Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2.


Pssm-ID: 464281  Cd Length: 171  Bit Score: 49.14  E-value: 1.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654605  846 TTLKALQDTTVRELCSCTVHEMEAMKTICQSFREYLEEIEQHLMGQQALFSRDMSEEEREEAEQLQTLREALRQQVAELE 925
Cdd:pfam14723   78 ASGYNTQRSSVLPLYENTFQELQVMRRSLNLFRTQMMDLELSMLRQQTMVYQHLTEEERYEADQLQSLRNSVRMELQELE 157


                   ....*.
gi 1034654605  926 FQLGDR 931
Cdd:pfam14723  158 LQLEDR 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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