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Conserved domains on  [gi|1034572430|ref|XP_016872830|]
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von Willebrand factor C and EGF domain-containing protein isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 683-901 9.41e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 9.41e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430  683 RACADPALLPGDccSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAP--------VNCSSCPGPPTASPSRPVLH 754
Cdd:PHA03247  2609 RGPAPPSPLPPD--THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprrARRLGRAAQASSPPQRPRRR 2686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430  755 LLQLL--LRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP--------PGAPTLPLASPGAPQP 824
Cdd:PHA03247  2687 AARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpagpatPGGPARPARPPTTAGP 2766

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034572430  825 PPVTPERSfSASGAQivSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 901
Cdd:PHA03247  2767 PAPAPPAA-PAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 458-516 1.30e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 43.57  E-value: 1.30e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572430 458 CYFHGRWYADGAVFSGggDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTC 516
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
529-582 1.10e-04

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.10e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034572430  529 DNGVEFPIGQIWSPgDPCELCICQADGSVSCKRTDC--VDSCPHPIRI--PGQCCPDC 582
Cdd:smart00214   3 HNGRVYNDGETWKP-DPCQICTCLDGTTVLCDPVECppPPDCPNPERVkpPGECCPRC 59
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 343-397 2.92e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 39.72  E-value: 2.92e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034572430 343 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAA-CSHPIPS-RDGGCCPSC 397
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLdCPNPRLEiPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
586-641 3.76e-04

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 3.76e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034572430  586 CTYTGRIFYNNETFPSvlDPCLSCICLLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 641
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 9.35e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 9.35e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034572430  142 DIDECVTS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 1.03e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.22  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|....*....
gi 1034572430 190 CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 644-699 2.24e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 37.02  E-value: 2.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572430 644 CNYEGRKVANGQVFTLDdePCTRCTCQLGEVSCEKVPCQRA-CADPAL--LPGDCCSSC 699
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLdCPNPRLeiPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 400-445 5.66e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 35.86  E-value: 5.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034572430 400 CFHSGVVRAEGDVFSPpnENCTVCVCLAGNVSCISPECPSGPCQTP 445
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNP 44
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 683-901 9.41e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 9.41e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430  683 RACADPALLPGDccSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAP--------VNCSSCPGPPTASPSRPVLH 754
Cdd:PHA03247  2609 RGPAPPSPLPPD--THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprrARRLGRAAQASSPPQRPRRR 2686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430  755 LLQLL--LRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP--------PGAPTLPLASPGAPQP 824
Cdd:PHA03247  2687 AARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpagpatPGGPARPARPPTTAGP 2766

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034572430  825 PPVTPERSfSASGAQivSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 901
Cdd:PHA03247  2767 PAPAPPAA-PAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 458-516 1.30e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.57  E-value: 1.30e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572430 458 CYFHGRWYADGAVFSGggDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTC 516
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
529-582 1.10e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.10e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034572430  529 DNGVEFPIGQIWSPgDPCELCICQADGSVSCKRTDC--VDSCPHPIRI--PGQCCPDC 582
Cdd:smart00214   3 HNGRVYNDGETWKP-DPCQICTCLDGTTVLCDPVECppPPDCPNPERVkpPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
458-516 2.30e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.81  E-value: 2.30e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034572430  458 CYFHGRWYADGAVFSGggDECTTCVCQNGE-VECSFMPCPE-LACPREEWRLGPGQCCFTC 516
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 343-397 2.92e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.92e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034572430 343 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAA-CSHPIPS-RDGGCCPSC 397
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLdCPNPRLEiPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
586-641 3.76e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 3.76e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034572430  586 CTYTGRIFYNNETFPSvlDPCLSCICLLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 641
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 9.35e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 9.35e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034572430  142 DIDECVTS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 1.03e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.22  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|....*....
gi 1034572430 190 CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
VWC smart00214
von Willebrand factor (vWF) type C domain;
343-397 1.11e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.88  E-value: 1.11e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572430  343 CWHLGAMHESRSRWTEPGCSQCWCEDGK-VTCEKVRCEAA--CSHPIPSRDGG-CCPSC 397
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpdCPNPERVKPPGeCCPRC 59
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 766-900 2.16e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430 766 KTQTLPTSPAGAHGPHSLAlglTATFPGEPGASPRLSPGPstPPGAPTL-PLASPGAPQPP----PVTPERSFSASGAQI 840
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAA---SPPSPPPPGTTQAATAGP--TPSAPSVpPQGSPATSQPPnqtqSTAAPHTLIQQTPTL 237

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034572430 841 VSRWPPLPGTLLTEASAlsmmDPSPSKTPITLLGPRVL----SPTTSRLSTALAATTHPGPQQP 900
Cdd:pfam03154 238 HPQRLPSPHPPLQPMTQ----PPPPSQVSPQPLPQPSLhgqmPPMPHSLQTGPSHMQHPVPPQP 297
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 644-699 2.24e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 2.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572430 644 CNYEGRKVANGQVFTLDdePCTRCTCQLGEVSCEKVPCQRA-CADPAL--LPGDCCSSC 699
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLdCPNPRLeiPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 586-641 2.78e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.63  E-value: 2.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572430 586 CTYTGRIFYNNETFpsVLDPCLSCICLLGSVACSPVDCPI-TCTYPFH--PDGECCPVC 641
Cdd:pfam00093   1 CVQNGVVYENGETW--KPDLCTICTCDDGKVLCDKIICPPlDCPNPRLeiPPGECCPVC 57
EGF_CA smart00179
Calcium-binding EGF-like domain;
181-214 3.98e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 3.98e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1034572430  181 DTDECL-GTPCQQ--RCKNSIGSYKCSCRTGFHLHGN 214
Cdd:smart00179   1 DIDECAsGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 181-212 4.63e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 4.63e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1034572430 181 DTDECL-GTPCQ--QRCKNSIGSYKCSCRTGFHLH 212
Cdd:cd00054     1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 400-445 5.66e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 35.86  E-value: 5.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034572430 400 CFHSGVVRAEGDVFSPpnENCTVCVCLAGNVSCISPECPSGPCQTP 445
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNP 44
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 683-901 9.41e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 9.41e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430  683 RACADPALLPGDccSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAP--------VNCSSCPGPPTASPSRPVLH 754
Cdd:PHA03247  2609 RGPAPPSPLPPD--THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprrARRLGRAAQASSPPQRPRRR 2686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430  755 LLQLL--LRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP--------PGAPTLPLASPGAPQP 824
Cdd:PHA03247  2687 AARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpagpatPGGPARPARPPTTAGP 2766

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034572430  825 PPVTPERSfSASGAQivSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 901
Cdd:PHA03247  2767 PAPAPPAA-PAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 458-516 1.30e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.57  E-value: 1.30e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572430 458 CYFHGRWYADGAVFSGggDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTC 516
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
529-582 1.10e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.10e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034572430  529 DNGVEFPIGQIWSPgDPCELCICQADGSVSCKRTDC--VDSCPHPIRI--PGQCCPDC 582
Cdd:smart00214   3 HNGRVYNDGETWKP-DPCQICTCLDGTTVLCDPVECppPPDCPNPERVkpPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
458-516 2.30e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.81  E-value: 2.30e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034572430  458 CYFHGRWYADGAVFSGggDECTTCVCQNGE-VECSFMPCPE-LACPREEWRLGPGQCCFTC 516
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKPPGECCPRC 59
PHA03247 PHA03247
large tegument protein UL36; Provisional
 731-901 2.56e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430  731 TEAPVNCSSCPGPPTASPSR-PVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATfPGEPGASP----RLSPGP 805
Cdd:PHA03247  2763 TAGPPAPAPPAAPAAGPPRRlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS-PAGPLPPPtsaqPTAPPP 2841

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430  806 STPPGAPTLPLA---SPGAP---QPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLS 879
Cdd:PHA03247  2842 PPGPPPPSLPLGgsvAPGGDvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQP 2921

                          170       180
                   ....*....|....*....|..
gi 1034572430  880 PTTSRLSTALAATTHPGPQQPP 901
Cdd:PHA03247  2922 QPPPPPQPQPPPPPPPRPQPPL 2943
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 343-397 2.92e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.92e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034572430 343 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAA-CSHPIPS-RDGGCCPSC 397
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLdCPNPRLEiPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
586-641 3.76e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 3.76e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034572430  586 CTYTGRIFYNNETFPSvlDPCLSCICLLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 641
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
motB PRK12799
flagellar motor protein MotB; Reviewed
 762-906 3.89e-04

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 43.94  E-value: 3.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430 762 TNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGasprlSPGPSTPPGAPTLPLASPgapqpppvTPERSFSASGAQIV 841
Cdd:PRK12799  288 TGLKQIDTHGTVPVAAVTPSSAVTQSSAITPSSAA-----IPSPAVIPSSVTTQSATT--------TQASAVALSSAGVL 354

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034572430 842 SRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPR-VLSPTTSRLSTALAATthPGPQQPPVGASR 906
Cdd:PRK12799  355 PSDVTLPGTVALPAAEPVNMQPQPMSTTETQQSSTgNITSTANGPTTSLPAA--PASNIPVSPTSR 418
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
719-901 4.50e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 4.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430 719 AFSKAGRSlhGDTeAPVNCSSCP---GPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPG-- 793
Cdd:PRK12323  362 AFRPGQSG--GGA-GPATAAAAPvaqPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAArq 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430 794 ----------EPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLltEASALSMMDP 863
Cdd:PRK12323  439 asargpggapAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEF--ASPAPAQPDA 516

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1034572430 864 SPS---KTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 901
Cdd:PRK12323  517 APAgwvAESIPDPATADPDDAFETLAPAPAAAPAPRAAAAT 557
PHA03247 PHA03247
large tegument protein UL36; Provisional
 741-901 5.26e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 5.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430  741 PGPPTASPSRPVLHLLQLLLRTNlmktqtlPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPG 820
Cdd:PHA03247  2557 PAAPPAAPDRSVPPPRPAPRPSE-------PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPP 2629

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430  821 APQPPPVT-PERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLsTALAATTHPGPQQ 899
Cdd:PHA03247  2630 SPSPAANEpDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSL-TSLADPPPPPPTP 2708


                   ..
gi 1034572430  900 PP 901
Cdd:PHA03247  2709 EP 2710
PHA03378 PHA03378
EBNA-3B; Provisional
 761-901 6.69e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.52  E-value: 6.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430 761 RTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQI 840
Cdd:PHA03378  663 KPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPG 742

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034572430 841 VSRWPP-LPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 901
Cdd:PHA03378  743 RARPPAaAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGP 804
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 9.35e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 9.35e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034572430  142 DIDECVTS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 740-912 1.02e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430  740 CPGPPTASPSRPVLHLLQLLLRTnlmktqTLPTSPAGAHGPHSlalGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASP 819
Cdd:PHA03307    72 PPGPGTEAPANESRSTPTWSLST------LAPASPAREGSPTP---PGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVG 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430  820 G---APQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMmdPSPSKTPITLLGPRVLSPTTSRL-STALAATTHP 895
Cdd:PHA03307   143 SpgpPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAP--SSPPAEPPPSTPPAAASPRPPRRsSPISASASSP 220

                          170
                   ....*....|....*..
gi 1034572430  896 GPQQPPVGASRGEESTM 912
Cdd:PHA03307   221 APAPGRSAADDAGASSS 237
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 1.03e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.22  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|....*....
gi 1034572430 190 CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
VWC smart00214
von Willebrand factor (vWF) type C domain;
343-397 1.11e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.88  E-value: 1.11e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572430  343 CWHLGAMHESRSRWTEPGCSQCWCEDGK-VTCEKVRCEAA--CSHPIPSRDGG-CCPSC 397
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpdCPNPERVKPPGeCCPRC 59
PHA03378 PHA03378
EBNA-3B; Provisional
 743-906 1.52e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.36  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430 743 PPTASPSRPVLHLLQLLLRTNLMktQTLPTSPAGAHGPH------SLALGLTATFPGEPGASPRlSPGPST------PPG 810
Cdd:PHA03378  616 PETSAPRQWPMPLRPIPMRPLRM--QPITFNVLVFPTPHqppqveITPYKPTWTQIGHIPYQPS-PTGANTmlpiqwAPG 692

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430 811 APTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPiTLLGPRVLSPTTSRLSTAL- 889
Cdd:PHA03378  693 TMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAP-GRARPPAAAPGRARPPAAAp 771

                         170
                  ....*....|....*...
gi 1034572430 890 -AATTHPGPQQPPVGASR 906
Cdd:PHA03378  772 gAPTPQPPPQAPPAPQQR 789
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
771-911 1.98e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430 771 PTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGT 850
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034572430 851 LLTEASAlsmmdPSPSKTPItllgPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEEST 911
Cdd:PRK12323  445 GGAPAPA-----PAPAAAPA----AAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDP 496
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 766-900 2.16e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430 766 KTQTLPTSPAGAHGPHSLAlglTATFPGEPGASPRLSPGPstPPGAPTL-PLASPGAPQPP----PVTPERSFSASGAQI 840
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAA---SPPSPPPPGTTQAATAGP--TPSAPSVpPQGSPATSQPPnqtqSTAAPHTLIQQTPTL 237

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034572430 841 VSRWPPLPGTLLTEASAlsmmDPSPSKTPITLLGPRVL----SPTTSRLSTALAATTHPGPQQP 900
Cdd:pfam03154 238 HPQRLPSPHPPLQPMTQ----PPPPSQVSPQPLPQPSLhgqmPPMPHSLQTGPSHMQHPVPPQP 297
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 644-699 2.24e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 2.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572430 644 CNYEGRKVANGQVFTLDdePCTRCTCQLGEVSCEKVPCQRA-CADPAL--LPGDCCSSC 699
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLdCPNPRLeiPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 586-641 2.78e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.63  E-value: 2.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572430 586 CTYTGRIFYNNETFpsVLDPCLSCICLLGSVACSPVDCPI-TCTYPFH--PDGECCPVC 641
Cdd:pfam00093   1 CVQNGVVYENGETW--KPDLCTICTCDDGKVLCDKIICPPlDCPNPRLeiPPGECCPVC 57
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 801-901 3.54e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.95  E-value: 3.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430 801 LSPGPSTPPGAPTLPLASPGAPQPPPVTPersFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTpitllgPRVLSP 880
Cdd:PRK14950  360 LVPVPAPQPAKPTAAAPSPVRPTPAPSTR---PKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHT------PESAPK 430

                          90       100
                  ....*....|....*....|.
gi 1034572430 881 TTSRLSTALAATTHPGPQQPP 901
Cdd:PRK14950  431 LTRAAIPVDEKPKYTPPAPPK 451
EGF_CA smart00179
Calcium-binding EGF-like domain;
181-214 3.98e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 3.98e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1034572430  181 DTDECL-GTPCQQ--RCKNSIGSYKCSCRTGFHLHGN 214
Cdd:smart00179   1 DIDECAsGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 181-212 4.63e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 4.63e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1034572430 181 DTDECL-GTPCQ--QRCKNSIGSYKCSCRTGFHLH 212
Cdd:cd00054     1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
PHA03379 PHA03379
EBNA-3A; Provisional
 706-902 5.61e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 40.43  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430 706 LEEKQGLSPHGNVAFSKAGRSLHGDteapvncsscPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGP----H 781
Cdd:PHA03379  391 LMRAGKLTERAREALEKASEPTYGT----------PRPPVEKPRPEVPQSLETATSHGSAQVPEPPPVHDLEPGPlhdqH 460

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430 782 SLALGLTATFPgePGASPRLSPGpSTPPGAPTLPLASPgAPQPPPVTP-ERSFSASGAQIVSRWP------PLPGTLLTE 854
Cdd:PHA03379  461 SMAPCPVAQLP--PGPLQDLEPG-DQLPGVVQDGRPAC-APVPAPAGPiVRPWEASLSQVPGVAFapvmpqPMPVEPVPV 536

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1034572430 855 ASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPV 902
Cdd:PHA03379  537 PTVALERPVCPAPPLIAMQGPGETSGIVRVRERWRPAPWTPNPPRSPS 584
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 400-445 5.66e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 35.86  E-value: 5.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034572430 400 CFHSGVVRAEGDVFSPpnENCTVCVCLAGNVSCISPECPSGPCQTP 445
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNP 44
PHA03247 PHA03247
large tegument protein UL36; Provisional
 741-902 8.97e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 8.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430  741 PGPPTASPSRPVLHLLQLLLRTNLMKTQ--------TLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAP 812
Cdd:PHA03247  2710 PAPHALVSATPLPPGPAAARQASPALPAapappavpAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVA 2789

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572430  813 TLPLASPGAPQPP-PVTPERSFSASGAQIVSRWPPLPG--TLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTAL 889
Cdd:PHA03247  2790 SLSESRESLPSPWdPADPPAAVLAPAAALPPAASPAGPlpPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSR 2869

                          170
                   ....*....|....
gi 1034572430  890 AATTHPG-PQQPPV 902
Cdd:PHA03247  2870 SPAAKPAaPARPPV 2883
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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