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Conserved domains on  [gi|1034574445|ref|XP_016873476|]
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alkaline ceramidase 3 isoform X3 [Homo sapiens]

Protein Classification

ceramidase( domain architecture ID 10531211)

ceramidase hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ceramidase pfam05875
Ceramidase; This family consists of several ceramidases. Ceramidases are enzymes involved in ...
 12-146 8.44e-61

Ceramidase; This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23. This family belongs to the CREST superfamily, which are distantly related to the GPCRs.


:

Pssm-ID: 461766  Cd Length: 259  Bit Score: 188.92  E-value: 8.44e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574445  12 GPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQLL 91
Cdd:pfam05875   1 GPVTSTIDWCEENYVVSPYIAEFVNTLSNLVFIILALYGIYLAYRNGLEKRFLLIYLGLILVGLGSWLFHMTLKYHGQLL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034574445  92 DELPMIYSCCIFVYCMFECFKIKnSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQ 146
Cdd:pfam05875  81 DELPMIYATCIPLYSLFSEGKSP-PYRRLLPLFLFLLAVILTVLYLVLKNPVFHQ 134
 
Name Accession Description Interval E-value
Ceramidase pfam05875
Ceramidase; This family consists of several ceramidases. Ceramidases are enzymes involved in ...
 12-146 8.44e-61

Ceramidase; This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23. This family belongs to the CREST superfamily, which are distantly related to the GPCRs.


Pssm-ID: 461766  Cd Length: 259  Bit Score: 188.92  E-value: 8.44e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574445  12 GPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQLL 91
Cdd:pfam05875   1 GPVTSTIDWCEENYVVSPYIAEFVNTLSNLVFIILALYGIYLAYRNGLEKRFLLIYLGLILVGLGSWLFHMTLKYHGQLL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034574445  92 DELPMIYSCCIFVYCMFECFKIKnSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQ 146
Cdd:pfam05875  81 DELPMIYATCIPLYSLFSEGKSP-PYRRLLPLFLFLLAVILTVLYLVLKNPVFHQ 134
 
Name Accession Description Interval E-value
Ceramidase pfam05875
Ceramidase; This family consists of several ceramidases. Ceramidases are enzymes involved in ...
 12-146 8.44e-61

Ceramidase; This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23. This family belongs to the CREST superfamily, which are distantly related to the GPCRs.


Pssm-ID: 461766  Cd Length: 259  Bit Score: 188.92  E-value: 8.44e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574445  12 GPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQLL 91
Cdd:pfam05875   1 GPVTSTIDWCEENYVVSPYIAEFVNTLSNLVFIILALYGIYLAYRNGLEKRFLLIYLGLILVGLGSWLFHMTLKYHGQLL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034574445  92 DELPMIYSCCIFVYCMFECFKIKnSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQ 146
Cdd:pfam05875  81 DELPMIYATCIPLYSLFSEGKSP-PYRRLLPLFLFLLAVILTVLYLVLKNPVFHQ 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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