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Conserved domains on  [gi|1034591423|ref|XP_016877935|]
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immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11471389)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-183 3.75e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 3.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  51 ANVTTLSLSANKITVLRRgAFADVTQVTSLWLAHNEVRTVePGALAVLSQLKNLDLSHNFISSFPwSDLRNLSALQLLKM 130
Cdd:COG4886   113 TNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDL 189

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034591423 131 NHNRLGSLPrDALGALPDLRSLRINNNRLRTLaPGTFDALSALSHLQLYHNPF 183
Cdd:COG4886   190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL 240
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 154-228 2.86e-13

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 72.42  E-value: 2.86e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034591423  154 INNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPAL 228
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLL 76
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 232-359 2.52e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.47  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423 232 PPSVHLSAEPPLEAPGTPLraglafVLHCIADGHPTPRLQWQLqipGGTVVLEPPVLSgeddgvgaeegegegdgdlltq 311
Cdd:pfam13927   1 KPVITVSPSSVTVREGETV------TLTCEATGSPPPTITWYK---NGEPISSGSTRS---------------------- 49

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1034591423 312 tqaqtptpapawpappatpRFLALANGSLLVPLLSAKEAGVYTCRAHN 359
Cdd:pfam13927  50 -------------------RSLSGSNSTLTISNVTRSDAGTYTCVASN 78
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 350-372 8.96e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member pfam07679:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 90  Bit Score: 35.31  E-value: 8.96e-03
                          10        20
                  ....*....|....*....|...
gi 1034591423 350 AGVYTCRAHNELGANSTSIRVAV 372
Cdd:pfam07679  68 SGKYTCVATNSAGEAEASAELTV 90
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-183 3.75e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 3.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  51 ANVTTLSLSANKITVLRRgAFADVTQVTSLWLAHNEVRTVePGALAVLSQLKNLDLSHNFISSFPwSDLRNLSALQLLKM 130
Cdd:COG4886   113 TNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDL 189

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034591423 131 NHNRLGSLPrDALGALPDLRSLRINNNRLRTLaPGTFDALSALSHLQLYHNPF 183
Cdd:COG4886   190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL 240
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 154-228 2.86e-13

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 72.42  E-value: 2.86e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034591423  154 INNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPAL 228
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLL 76
LRR_8 pfam13855
Leucine rich repeat;
52-109 2.32e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 2.32e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034591423  52 NVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHN 109
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-181 1.45e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.87  E-value: 1.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  52 NVTTLSLSANKITVLRRGAFAdvTQVTSLWLAHNEVRTVEPgaLAVLSQLKNLDLSHNFISSFpwSDLRNLSALQLLKMN 131
Cdd:cd21340    25 NLKVLYLYDNKITKIENLEFL--TNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIE 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034591423 132 HNRLGS------LPRDALGALPDLRSLRINNNRLRTLAPgtFDALSALSHLQLYHN 181
Cdd:cd21340    99 NQRLPPgekltfDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNN 152
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
41-235 3.02e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.33  E-value: 3.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  41 ELREVPEGLPANVTTLSLSANKITVLrrgafadvtqvtslwlahnevrtvePGALAvlSQLKNLDLSHNFISSFPwsdLR 120
Cdd:PRK15370  210 ELKSLPENLQGNIKTLYANSNQLTSI-------------------------PATLP--DTIQEMELSINRITELP---ER 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423 121 NLSALQLLKMNHNRLGSLPRDalgaLPD-LRSLRINNNRLRTLaPGTFDalSALSHLQLYHN-----PFHCGCGLVWLQA 194
Cdd:PRK15370  260 LPSALQSLDLFHNKISCLPEN----LPEeLRYLSVYDNSIRTL-PAHLP--SGITHLNVQSNsltalPETLPPGLKTLEA 332

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1034591423 195 wAASTRVSLPEpdsiacASPPALQGVPVY--RLPALP-CAPPSV 235
Cdd:PRK15370  333 -GENALTSLPA------SLPPELQVLDVSknQITVLPeTLPPTI 369
LRRCT smart00082
Leucine rich repeat C-terminal domain;
181-229 8.40e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 8.40e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1034591423  181 NPFHCGCGLVWLQAWAASTRVsLPEPDSIACASPPALQGvPVYRLPALP 229
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEH-LQDPVDLRCASPSSLRG-PLLELLHSE 47
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 232-359 2.52e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.47  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423 232 PPSVHLSAEPPLEAPGTPLraglafVLHCIADGHPTPRLQWQLqipGGTVVLEPPVLSgeddgvgaeegegegdgdlltq 311
Cdd:pfam13927   1 KPVITVSPSSVTVREGETV------TLTCEATGSPPPTITWYK---NGEPISSGSTRS---------------------- 49

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1034591423 312 tqaqtptpapawpappatpRFLALANGSLLVPLLSAKEAGVYTCRAHN 359
Cdd:pfam13927  50 -------------------RSLSGSNSTLTISNVTRSDAGTYTCVASN 78
IgI_5_Robo cd20952
Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the ...
 248-372 4.76e-03

Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth Ig-like domain of Roundabout (Robo) homolog 1/2 and similar domains. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, -2, and -3), and three mammalian Slit homologs (Slit-1,-2, -3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, -2, and -3 are expressed by commissural neurons in the vertebrate spinal cord and Slits 1, -2, -3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of slit responsiveness, antagonizes slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. The fifth Ig-like domain of Robo 1 and 2 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors


Pssm-ID: 409544 [Multi-domain]  Cd Length: 87  Bit Score: 36.32  E-value: 4.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423 248 TPLRAGLAFVLHCIADGHPTPRLQWQLQipggtvvleppvlsgeddgvgaeegegegDGDLLTQTQaqtptpapawpapp 327
Cdd:cd20952     9 QTVAVGGTVVLNCQATGEPVPTISWLKD-----------------------------GVPLLGKDE-------------- 45

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1034591423 328 atpRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAV 372
Cdd:cd20952    46 ---RITTLENGSLQIKGAEKSDTGEYTCVALNLSGEATWSAVLDV 87
I-set pfam07679
Immunoglobulin I-set domain;
350-372 8.96e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 35.31  E-value: 8.96e-03
                          10        20
                  ....*....|....*....|...
gi 1034591423 350 AGVYTCRAHNELGANSTSIRVAV 372
Cdd:pfam07679  68 SGKYTCVATNSAGEAEASAELTV 90
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-183 3.75e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 3.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  51 ANVTTLSLSANKITVLRRgAFADVTQVTSLWLAHNEVRTVePGALAVLSQLKNLDLSHNFISSFPwSDLRNLSALQLLKM 130
Cdd:COG4886   113 TNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDL 189

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034591423 131 NHNRLGSLPrDALGALPDLRSLRINNNRLRTLaPGTFDALSALSHLQLYHNPF 183
Cdd:COG4886   190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-184 1.55e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.38  E-value: 1.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  36 DCAYKELREVPE---GLPaNVTTLSLSANKITVLRrGAFADVTQVTSLWLAHNEVRTVePGALAVLSQLKNLDLSHNFIS 112
Cdd:COG4886   165 DLSNNQLTDLPEelgNLT-NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLT 241

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034591423 113 SFPWsdLRNLSALQLLKMNHNRLGSLPrdALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFH 184
Cdd:COG4886   242 DLPE--LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-183 9.75e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 9.75e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  51 ANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEvrtvepgALAVLSQLKNLDLSHNFISSFPWSdLRNLSALQLLKM 130
Cdd:COG4886    72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDL 143

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034591423 131 NHNRLGSLPrDALGALPDLRSLRINNNRLRTLaPGTFDALSALSHLQLYHNPF 183
Cdd:COG4886   144 SNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 154-228 2.86e-13

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 72.42  E-value: 2.86e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034591423  154 INNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPAL 228
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLL 76
LRR_8 pfam13855
Leucine rich repeat;
52-109 2.32e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 2.32e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034591423  52 NVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHN 109
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
99-159 3.33e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 3.33e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034591423  99 SQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRL 159
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
120-183 1.69e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 1.69e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034591423 120 RNLSALQLlkmNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPF 183
Cdd:pfam13855   1 PNLRSLDL---SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-181 1.45e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.87  E-value: 1.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  52 NVTTLSLSANKITVLRRGAFAdvTQVTSLWLAHNEVRTVEPgaLAVLSQLKNLDLSHNFISSFpwSDLRNLSALQLLKMN 131
Cdd:cd21340    25 NLKVLYLYDNKITKIENLEFL--TNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIE 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034591423 132 HNRLGS------LPRDALGALPDLRSLRINNNRLRTLAPgtFDALSALSHLQLYHN 181
Cdd:cd21340    99 NQRLPPgekltfDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNN 152
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
41-235 3.02e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.33  E-value: 3.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  41 ELREVPEGLPANVTTLSLSANKITVLrrgafadvtqvtslwlahnevrtvePGALAvlSQLKNLDLSHNFISSFPwsdLR 120
Cdd:PRK15370  210 ELKSLPENLQGNIKTLYANSNQLTSI-------------------------PATLP--DTIQEMELSINRITELP---ER 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423 121 NLSALQLLKMNHNRLGSLPRDalgaLPD-LRSLRINNNRLRTLaPGTFDalSALSHLQLYHN-----PFHCGCGLVWLQA 194
Cdd:PRK15370  260 LPSALQSLDLFHNKISCLPEN----LPEeLRYLSVYDNSIRTL-PAHLP--SGITHLNVQSNsltalPETLPPGLKTLEA 332

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1034591423 195 wAASTRVSLPEpdsiacASPPALQGVPVY--RLPALP-CAPPSV 235
Cdd:PRK15370  333 -GENALTSLPA------SLPPELQVLDVSknQITVLPeTLPPTI 369
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-184 2.12e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 2.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  36 DCAYKELREVPEGLPA--NVTTLSLSANKITVLRrgAFADVTQVTSLWLAHNEVRTVEPgaLAVLSQLKNLDLSHNFISS 113
Cdd:COG4886   211 DLSGNQLTDLPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTD 286

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034591423 114 FPWSDLRNLSALQLLKMNHNRLGSLPrdALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFH 184
Cdd:COG4886   287 LKLKELELLLGLNSLLLLLLLLNLLE--LLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLL 355
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 53-181 6.21e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 6.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  53 VTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVlSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNH 132
Cdd:PLN00113  430 VYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSE 508

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034591423 133 NRL-GSLPrDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHN 181
Cdd:PLN00113  509 NKLsGEIP-DELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN 557
LRRCT smart00082
Leucine rich repeat C-terminal domain;
181-229 8.40e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 8.40e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1034591423  181 NPFHCGCGLVWLQAWAASTRVsLPEPDSIACASPPALQGvPVYRLPALP 229
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEH-LQDPVDLRCASPSSLRG-PLLELLHSE 47
PLN03150 PLN03150
hypothetical protein; Provisional
 77-170 2.43e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.81  E-value: 2.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  77 VTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRL-GSLPrDALGALPDLRSLRIN 155
Cdd:PLN03150  420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFnGSIP-ESLGQLTSLRILNLN 498

                          90
                  ....*....|....*
gi 1034591423 156 NNRLRTLAPGTFDAL 170
Cdd:PLN03150  499 GNSLSGRVPAALGGR 513
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
33-205 2.60e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 2.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  33 QFADCAYKELREVPEGLPANVTTLSLSANKITVLRRgAFADVTQVTSLWlaHNEVRTVePGALAvlSQLKNLDLSHNFIS 112
Cdd:PRK15370  244 QEMELSINRITELPERLPSALQSLDLFHNKISCLPE-NLPEELRYLSVY--DNSIRTL-PAHLP--SGITHLNVQSNSLT 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423 113 SFPWSDLRNlsaLQLLKMNHNRLGSLPRDalgALPDLRSLRINNNRLRTLA---PGTFDALSaLSHLQLYHNPFHCGCGL 189
Cdd:PRK15370  318 ALPETLPPG---LKTLEAGENALTSLPAS---LPPELQVLDVSKNQITVLPetlPPTITTLD-VSRNALTNLPENLPAAL 390

                         170
                  ....*....|....*.
gi 1034591423 190 VWLQAwAASTRVSLPE 205
Cdd:PRK15370  391 QIMQA-SRNNLVRLPE 405
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 48-172 3.22e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 3.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  48 GLP-----ANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNL 122
Cdd:PLN00113  467 GLPdsfgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEM 546

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034591423 123 SALQLLKMNHNRL-GSLPRDaLGALPDLRSLRINNNRLRTLAP--GTFDALSA 172
Cdd:PLN00113  547 PVLSQLDLSQNQLsGEIPKN-LGNVESLVQVNISHNHLHGSLPstGAFLAINA 598
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 56-184 4.21e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 4.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  56 LSLSANKITvlrrGAFADV---TQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNH 132
Cdd:PLN00113  457 LSLARNKFF----GGLPDSfgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSH 532

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034591423 133 NRL-GSLPrDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFH 184
Cdd:PLN00113  533 NQLsGQIP-ASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH 584
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 48-181 1.67e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  48 GLPANVTTLS-------LSANKIT-VLRRGAfadVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDL 119
Cdd:PLN00113  108 PIPDDIFTTSsslrylnLSNNNFTgSIPRGS---IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSL 184

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034591423 120 RNLSALQLLKMNHNRL-GSLPRDaLGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHN 181
Cdd:PLN00113  185 TNLTSLEFLTLASNQLvGQIPRE-LGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN 246
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 42-182 6.37e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 6.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  42 LREVPEGLPANV--TTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVL--------SQLKNLDLSHNFI 111
Cdd:cd00116    70 LQSLLQGLTKGCglQELDLSDNALGPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLakglkdlpPALEKLVLGRNRL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423 112 ---SSFPWSD-LRNLSALQLLKMNHNRLG-----SLPRdALGALPDLRSLRINNNRLR-----TLApGTFDALSALSHLQ 177
Cdd:cd00116   150 egaSCEALAKaLRANRDLKELNLANNGIGdagirALAE-GLKANCNLEVLDLNNNGLTdegasALA-ETLASLKSLEVLN 227


                  ....*
gi 1034591423 178 LYHNP 182
Cdd:cd00116   228 LGDNN 232
PLN03150 PLN03150
hypothetical protein; Provisional
 79-155 7.15e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.19  E-value: 7.15e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034591423  79 SLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFIS-SFPWSdLRNLSALQLLKMNHNRL-GSLPrDALGALPdLRSLRIN 155
Cdd:PLN03150  446 SINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPES-LGQLTSLRILNLNGNSLsGRVP-AALGGRL-LHRASFN 521
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 33-136 1.35e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.01  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  33 QFADCAYKELREVPEGLPAnVTTLSLSANKITVLRRGAFADV----TQVTSLWLAHNEVRtvEPGA------LAVLSQLK 102
Cdd:COG5238   219 PIGDEGAEILAEALKGNKS-LTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGNQIG--AEGAialakaLQGNTTLT 295

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1034591423 103 NLDLSHNFISSFPW----SDLRNLSALQLLKMNHNRLG 136
Cdd:COG5238   296 SLDLSVNRIGDEGAialaEGLQGNKTLHTLNLAYNGIG 333
LRR_9 pfam14580
Leucine-rich repeat;
96-182 1.62e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.44  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  96 AVLSQLKNLDLSHNFI---SSFPWsdlrnLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLapGTFDALSA 172
Cdd:pfam14580  39 ATLDQFDTIDFSDNEIrklDGFPL-----LRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQEL--GDLDPLAS 111

                          90
                  ....*....|...
gi 1034591423 173 LSHLQ---LYHNP 182
Cdd:pfam14580 112 LKKLTflsLLRNP 124
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 232-359 2.52e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.47  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423 232 PPSVHLSAEPPLEAPGTPLraglafVLHCIADGHPTPRLQWQLqipGGTVVLEPPVLSgeddgvgaeegegegdgdlltq 311
Cdd:pfam13927   1 KPVITVSPSSVTVREGETV------TLTCEATGSPPPTITWYK---NGEPISSGSTRS---------------------- 49

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1034591423 312 tqaqtptpapawpappatpRFLALANGSLLVPLLSAKEAGVYTCRAHN 359
Cdd:pfam13927  50 -------------------RSLSGSNSTLTISNVTRSDAGTYTCVASN 78
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 51-183 6.28e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 6.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423  51 ANVTTL---SLSANKITvlrRGAFADVTQVTSL---WLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSA 124
Cdd:PLN00113  185 TNLTSLeflTLASNQLV---GQIPRELGQMKSLkwiYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKN 261

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423 125 LQLLKMNHNRL-GSLPRDALGaLPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPF 183
Cdd:PLN00113  262 LQYLFLYQNKLsGPIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNF 320
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 82-140 3.30e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 3.30e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034591423  82 LAHNEVRTVEPgaLAVLSQLKNLDLSHNFISSFpwSD----LRNLSALQLLKMNHNRLGSLPR 140
Cdd:cd21340   127 ISGNNIDSLEP--LAPLRNLEQLDASNNQISDL--EElldlLSSWPSLRELDLTGNPVCKKPK 185
IgI_5_Robo cd20952
Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the ...
 248-372 4.76e-03

Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth Ig-like domain of Roundabout (Robo) homolog 1/2 and similar domains. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, -2, and -3), and three mammalian Slit homologs (Slit-1,-2, -3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, -2, and -3 are expressed by commissural neurons in the vertebrate spinal cord and Slits 1, -2, -3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of slit responsiveness, antagonizes slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. The fifth Ig-like domain of Robo 1 and 2 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors


Pssm-ID: 409544 [Multi-domain]  Cd Length: 87  Bit Score: 36.32  E-value: 4.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591423 248 TPLRAGLAFVLHCIADGHPTPRLQWQLQipggtvvleppvlsgeddgvgaeegegegDGDLLTQTQaqtptpapawpapp 327
Cdd:cd20952     9 QTVAVGGTVVLNCQATGEPVPTISWLKD-----------------------------GVPLLGKDE-------------- 45

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1034591423 328 atpRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAV 372
Cdd:cd20952    46 ---RITTLENGSLQIKGAEKSDTGEYTCVALNLSGEATWSAVLDV 87
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 75-121 6.37e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 6.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1034591423  75 TQVTSLWLAHNEVRTVEPgaLAVLSQLKNLDLSHNFISSfPWSDLRN 121
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKIT-DLSDLAN 44
I-set pfam07679
Immunoglobulin I-set domain;
350-372 8.96e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 35.31  E-value: 8.96e-03
                          10        20
                  ....*....|....*....|...
gi 1034591423 350 AGVYTCRAHNELGANSTSIRVAV 372
Cdd:pfam07679  68 SGKYTCVATNSAGEAEASAELTV 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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