|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
134-317 |
5.77e-100 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 305.97 E-value: 5.77e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLV 213
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKYCNIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 214 GYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATIN 293
Cdd:cd17988 81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRHVKIILMSATIS 160
|
170 180
....*....|....*....|....
gi 1039742015 294 CKQFADYFAVPVqnkmNPAYVFEV 317
Cdd:cd17988 161 CKEFADYFTTPN----NPAYVFEV 180
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
132-706 |
5.84e-96 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 316.64 E-value: 5.84e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 132 PDLPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHytQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGG 211
Cdd:COG1643 8 PDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLEL--GWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 212 LVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFlllvvrkllrtnsrfvKVVLMSAT 291
Cdd:COG1643 86 TVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLllallldlqpalrpdlKLLVMSAT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 292 INCKQFADYFavpvqnkmNPAYVFEVEGKPHAIEEYYLNDLGHiyhsglPYRLEEPVITkdvyevAVsliqmfDDLDMKE 371
Cdd:COG1643 166 LDAERFARLL--------GDAPVIESSGRTYPVEVRYRPLPAD------ERDLEDAVAD------AV------REALAEE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 372 SGnktwsgaqfvsersSVLVFLPGLGEINYMHELLTNMIHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAES 451
Cdd:COG1643 220 PG--------------DILVFLPGEREIRRTAEALRGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAET 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 452 SVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRKGRAGRVSKGYCYRLIPRDFWDSAiPDHVVPEMLRCP 531
Cdd:COG1643 286 SLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARR-PAFTDPEILRAD 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 532 LGSTILKVKLLDMGEPRALlaTALSPPSLSDIERTILLLKEVGALavsgqreDEnphDGELTFLGRVLAQLPVSQQLGKL 611
Cdd:COG1643 365 LASLILELAAWGLGDPEDL--PFLDPPPARAIADARALLQELGAL-------DA---DGRLTPLGRALARLPLDPRLARM 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 612 VVLGHVFGCLDECLIIAAALSLKNfftmPFRQhldgyrnkvhfsgSSRSDCLALVEAFRAWQACRQRgelrrpkdeldwg 691
Cdd:COG1643 433 LLAAAELGCLREAAILAALLSERD----PRRG-------------AAGSDLLARLNLWRRLREQQRE------------- 482
|
570
....*....|....*
gi 1039742015 692 RLNYIQIKRIREVAE 706
Cdd:COG1643 483 FLSYLRLREWRDLAR 497
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
128-737 |
4.23e-74 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 262.30 E-value: 4.23e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 128 TYKYPD-LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDhyTQRSAFCNIVVTQPRKIGASSIARWISKERS 206
Cdd:PRK11131 66 EITYPEnLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLE--LGRGVKGLIGHTQPRRLAARTVANRIAEELE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 207 WTLGGLVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRfVKVV 286
Cdd:PRK11131 144 TELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPD-LKVI 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 287 LMSATINCKQFADYFavpvqnkmNPAYVFEVEGKPHAIEeyylndlghiyhsgLPYRleePVITKDVYEVAVSLIQMFDD 366
Cdd:PRK11131 223 ITSATIDPERFSRHF--------NNAPIIEVSGRTYPVE--------------VRYR---PIVEEADDTERDQLQAIFDA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 367 LDmkESGNKTwsgaqfvseRSSVLVFLPGLGEINYMHELLTNMIHKRLQVYPLHSSVTLEEQNNVFLSPvpGYRKIILST 446
Cdd:PRK11131 278 VD--ELGREG---------PGDILIFMSGEREIRDTADALNKLNLRHTEILPLYARLSNSEQNRVFQSH--SGRRIVLAT 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 447 NIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRKGRAGRVSKGYCYRLIPRDFWDSAiPDHVVPE 526
Cdd:PRK11131 345 NVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSR-PEFTDPE 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 527 MLRCPLGSTILKVKLLDMGEPRALlaTALSPPSLSDIERTILLLKEVGALavsgqREDENPHDGELTFLGRVLAQLPVSQ 606
Cdd:PRK11131 424 ILRTNLASVILQMTALGLGDIAAF--PFVEAPDKRNIQDGVRLLEELGAI-----TTDEQASAYKLTPLGRQLAQLPVDP 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 607 QLGKLVVLGHVFGCLDECLIIAAALSLKNFFTMPF--RQHLDGYRNKVHfsgSSRSDCLALVEAFRAWQAcrQRGELR-- 682
Cdd:PRK11131 497 RLARMVLEAQKHGCVREVMIITSALSIQDPRERPMdkQQASDEKHRRFA---DKESDFLAFVNLWNYLQE--QQKALSsn 571
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*..
gi 1039742015 683 --RPKDELDWgrLNYIqikRIREVAELYEELKNRISQFNMfvgphhPVLDQEYPYKQ 737
Cdd:PRK11131 572 qfRRLCRTDY--LNYL---RVREWQDIYTQLRQVVKELGI------PVNSEPAEYRE 617
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
322-509 |
2.17e-62 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 206.62 E-value: 2.17e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 322 HAIEEYYLNDLGHIYHSglpyrlEEPVITKDVYEVAVSLIqmFDDLDMKESGnktwsgaqfvsersSVLVFLPGLGEINY 401
Cdd:cd18791 1 FPVEVYYLEDILELLGI------SSEKEDPDYVDAAVRLI--LQIHRTEEPG--------------DILVFLPGQEEIER 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 402 MHELLTNMIH----KRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTN 477
Cdd:cd18791 59 LCELLREELLspdlGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTG 138
|
170 180 190
....*....|....*....|....*....|..
gi 1039742015 478 YQSLRLSWASKTSCDQRKGRAGRVSKGYCYRL 509
Cdd:cd18791 139 LSSLVTVWISKASAEQRAGRAGRTRPGKCYRL 170
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
134-690 |
1.66e-56 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 207.70 E-value: 1.66e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHytqRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLV 213
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDA---PGIGGKIIMLEPRRLAARSAAQRLASQLGEAVGQTV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 214 GYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATIN 293
Cdd:TIGR01970 78 GYRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSLREDLKILAMSATLD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 294 CKQfadyfavpVQNKMNPAYVFEVEGKPHAIEEYYLndlghiyhsglPYRLEEPVITKDVYEVAVSLIQmfddldmkESG 373
Cdd:TIGR01970 158 GER--------LSSLLPDAPVVESEGRSFPVEIRYL-----------PLRGDQRLEDAVSRAVEHALAS--------ETG 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 374 nktwsgaqfvsersSVLVFLPGLGEINYMHELLTNMIHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSV 453
Cdd:TIGR01970 211 --------------SILVFLPGQAEIRRVQEQLAERLDSDVLICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 454 TVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRKGRAGRVSKGYCYRLIPRDFWDSAiPDHVVPEMLRCPLG 533
Cdd:TIGR01970 277 TIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGRLEPGVCYRLWSEEQHQRL-PAQDEPEILQADLS 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 534 STILKVKLLDMGEPRALlaTALSPPSLSDIERTILLLKEVGALAVSGQredenphdgeLTFLGRVLAQLPVSQQLGKLVV 613
Cdd:TIGR01970 356 GLALELAQWGAKDPSDL--RWLDAPPSVALAAARQLLQRLGALDAQGR----------LTAHGKAMAALGCHPRLAAMLL 423
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039742015 614 LGHVFGCLDECLIIAAALSLKNfftmPFRQHLDGYRNKVHFSGSSRSDCLAlveafRAWQACRQ-RGELRRPKDELDW 690
Cdd:TIGR01970 424 SAHSTGLAALACDLAALLEERG----LPRQGGADLMNRLHRLQQGRQGRGQ-----RAQQLAKKlRRRLRFSQADSGA 492
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
146-293 |
3.13e-18 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 83.70 E-value: 3.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 146 LIESNSVVIIHGATGSGKSTQLPQYVLDHYtQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLVGYQVG------L 219
Cdd:smart00487 20 LLSGLRDVILAAPTGSGKTLAALLPALEAL-KRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLYGGdskreqL 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039742015 220 EKIATEDTRLIYMTTGVLLQKIVS-AKSLMEFTHIFIDEVHeRTEEMDFLLLVVRKLLRTNSRfVKVVLMSATIN 293
Cdd:smart00487 99 RKLESGKTDILVTTPGRLLDLLENdKLSLSNVDLVILDEAH-RLLDGGFGDQLEKLLKLLPKN-VQLLLLSATPP 171
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
589-666 |
7.40e-17 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 75.77 E-value: 7.40e-17
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039742015 589 DGELTFLGRVLAQLPVSQQLGKLVVLGHVFGCLDECLIIAAALSLKNFFTMPFRQHLDGYRNKVHfsgSSRSDCLALV 666
Cdd:smart00847 8 DGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPKEKREDADAARRRFA---DPESDHLTLL 82
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
567-647 |
2.53e-16 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 74.97 E-value: 2.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 567 ILLLKEVGALavsgqreDEnphDGELTFLGRVLAQLPVSQQLGKLVVLGHVFGCLDECLIIAAALSLKNFFTMPFRQHLD 646
Cdd:pfam04408 2 LELLYYLGAL-------DE---DGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPR 71
|
.
gi 1039742015 647 G 647
Cdd:pfam04408 72 S 72
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
141-293 |
7.48e-08 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 52.63 E-value: 7.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 141 EEVISLIESNSVVIIHGATGSGKST--QLPqyVLDHYTQRSAFCNIVVTQPRKIGASSIARWIsKERSWTLGGLVGYQVG 218
Cdd:pfam00270 5 AEAIPAILEGRDVLVQAPTGSGKTLafLLP--ALEALDKLDNGPQALVLAPTRELAEQIYEEL-KKLGKGLGLKVASLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 219 -------LEKIATedTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHeRTEEMDFLLLVVRKLLRTNSRfVKVVLMSAT 291
Cdd:pfam00270 82 gdsrkeqLEKLKG--PDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFGPDLEEILRRLPKK-RQILLLSAT 157
|
..
gi 1039742015 292 IN 293
Cdd:pfam00270 158 LP 159
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
134-317 |
5.77e-100 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 305.97 E-value: 5.77e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLV 213
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKYCNIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 214 GYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATIN 293
Cdd:cd17988 81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRHVKIILMSATIS 160
|
170 180
....*....|....*....|....
gi 1039742015 294 CKQFADYFAVPVqnkmNPAYVFEV 317
Cdd:cd17988 161 CKEFADYFTTPN----NPAYVFEV 180
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
132-706 |
5.84e-96 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 316.64 E-value: 5.84e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 132 PDLPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHytQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGG 211
Cdd:COG1643 8 PDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLEL--GWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 212 LVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFlllvvrkllrtnsrfvKVVLMSAT 291
Cdd:COG1643 86 TVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLllallldlqpalrpdlKLLVMSAT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 292 INCKQFADYFavpvqnkmNPAYVFEVEGKPHAIEEYYLNDLGHiyhsglPYRLEEPVITkdvyevAVsliqmfDDLDMKE 371
Cdd:COG1643 166 LDAERFARLL--------GDAPVIESSGRTYPVEVRYRPLPAD------ERDLEDAVAD------AV------REALAEE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 372 SGnktwsgaqfvsersSVLVFLPGLGEINYMHELLTNMIHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAES 451
Cdd:COG1643 220 PG--------------DILVFLPGEREIRRTAEALRGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAET 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 452 SVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRKGRAGRVSKGYCYRLIPRDFWDSAiPDHVVPEMLRCP 531
Cdd:COG1643 286 SLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARR-PAFTDPEILRAD 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 532 LGSTILKVKLLDMGEPRALlaTALSPPSLSDIERTILLLKEVGALavsgqreDEnphDGELTFLGRVLAQLPVSQQLGKL 611
Cdd:COG1643 365 LASLILELAAWGLGDPEDL--PFLDPPPARAIADARALLQELGAL-------DA---DGRLTPLGRALARLPLDPRLARM 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 612 VVLGHVFGCLDECLIIAAALSLKNfftmPFRQhldgyrnkvhfsgSSRSDCLALVEAFRAWQACRQRgelrrpkdeldwg 691
Cdd:COG1643 433 LLAAAELGCLREAAILAALLSERD----PRRG-------------AAGSDLLARLNLWRRLREQQRE------------- 482
|
570
....*....|....*
gi 1039742015 692 RLNYIQIKRIREVAE 706
Cdd:COG1643 483 FLSYLRLREWRDLAR 497
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
128-737 |
4.23e-74 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 262.30 E-value: 4.23e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 128 TYKYPD-LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDhyTQRSAFCNIVVTQPRKIGASSIARWISKERS 206
Cdd:PRK11131 66 EITYPEnLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLE--LGRGVKGLIGHTQPRRLAARTVANRIAEELE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 207 WTLGGLVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRfVKVV 286
Cdd:PRK11131 144 TELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPD-LKVI 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 287 LMSATINCKQFADYFavpvqnkmNPAYVFEVEGKPHAIEeyylndlghiyhsgLPYRleePVITKDVYEVAVSLIQMFDD 366
Cdd:PRK11131 223 ITSATIDPERFSRHF--------NNAPIIEVSGRTYPVE--------------VRYR---PIVEEADDTERDQLQAIFDA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 367 LDmkESGNKTwsgaqfvseRSSVLVFLPGLGEINYMHELLTNMIHKRLQVYPLHSSVTLEEQNNVFLSPvpGYRKIILST 446
Cdd:PRK11131 278 VD--ELGREG---------PGDILIFMSGEREIRDTADALNKLNLRHTEILPLYARLSNSEQNRVFQSH--SGRRIVLAT 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 447 NIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRKGRAGRVSKGYCYRLIPRDFWDSAiPDHVVPE 526
Cdd:PRK11131 345 NVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSR-PEFTDPE 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 527 MLRCPLGSTILKVKLLDMGEPRALlaTALSPPSLSDIERTILLLKEVGALavsgqREDENPHDGELTFLGRVLAQLPVSQ 606
Cdd:PRK11131 424 ILRTNLASVILQMTALGLGDIAAF--PFVEAPDKRNIQDGVRLLEELGAI-----TTDEQASAYKLTPLGRQLAQLPVDP 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 607 QLGKLVVLGHVFGCLDECLIIAAALSLKNFFTMPF--RQHLDGYRNKVHfsgSSRSDCLALVEAFRAWQAcrQRGELR-- 682
Cdd:PRK11131 497 RLARMVLEAQKHGCVREVMIITSALSIQDPRERPMdkQQASDEKHRRFA---DKESDFLAFVNLWNYLQE--QQKALSsn 571
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*..
gi 1039742015 683 --RPKDELDWgrLNYIqikRIREVAELYEELKNRISQFNMfvgphhPVLDQEYPYKQ 737
Cdd:PRK11131 572 qfRRLCRTDY--LNYL---RVREWQDIYTQLRQVVKELGI------PVNSEPAEYRE 617
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
150-301 |
5.22e-63 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 207.70 E-value: 5.22e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 150 NSVVIIHGATGSGKSTQLPQYVLDHYTQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLVGYQVGLEKIATEDTRL 229
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039742015 230 IYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRFvKVVLMSATINCKQFADYF 301
Cdd:cd17917 81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDL-KVILMSATLDAEKFSSYF 151
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
322-509 |
2.17e-62 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 206.62 E-value: 2.17e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 322 HAIEEYYLNDLGHIYHSglpyrlEEPVITKDVYEVAVSLIqmFDDLDMKESGnktwsgaqfvsersSVLVFLPGLGEINY 401
Cdd:cd18791 1 FPVEVYYLEDILELLGI------SSEKEDPDYVDAAVRLI--LQIHRTEEPG--------------DILVFLPGQEEIER 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 402 MHELLTNMIH----KRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTN 477
Cdd:cd18791 59 LCELLREELLspdlGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTG 138
|
170 180 190
....*....|....*....|....*....|..
gi 1039742015 478 YQSLRLSWASKTSCDQRKGRAGRVSKGYCYRL 509
Cdd:cd18791 139 LSSLVTVWISKASAEQRAGRAGRTRPGKCYRL 170
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
134-690 |
1.66e-56 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 207.70 E-value: 1.66e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHytqRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLV 213
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDA---PGIGGKIIMLEPRRLAARSAAQRLASQLGEAVGQTV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 214 GYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATIN 293
Cdd:TIGR01970 78 GYRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSLREDLKILAMSATLD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 294 CKQfadyfavpVQNKMNPAYVFEVEGKPHAIEEYYLndlghiyhsglPYRLEEPVITKDVYEVAVSLIQmfddldmkESG 373
Cdd:TIGR01970 158 GER--------LSSLLPDAPVVESEGRSFPVEIRYL-----------PLRGDQRLEDAVSRAVEHALAS--------ETG 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 374 nktwsgaqfvsersSVLVFLPGLGEINYMHELLTNMIHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSV 453
Cdd:TIGR01970 211 --------------SILVFLPGQAEIRRVQEQLAERLDSDVLICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 454 TVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRKGRAGRVSKGYCYRLIPRDFWDSAiPDHVVPEMLRCPLG 533
Cdd:TIGR01970 277 TIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGRLEPGVCYRLWSEEQHQRL-PAQDEPEILQADLS 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 534 STILKVKLLDMGEPRALlaTALSPPSLSDIERTILLLKEVGALAVSGQredenphdgeLTFLGRVLAQLPVSQQLGKLVV 613
Cdd:TIGR01970 356 GLALELAQWGAKDPSDL--RWLDAPPSVALAAARQLLQRLGALDAQGR----------LTAHGKAMAALGCHPRLAAMLL 423
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039742015 614 LGHVFGCLDECLIIAAALSLKNfftmPFRQHLDGYRNKVHFSGSSRSDCLAlveafRAWQACRQ-RGELRRPKDELDW 690
Cdd:TIGR01970 424 SAHSTGLAALACDLAALLEERG----LPRQGGADLMNRLHRLQQGRQGRGQ-----RAQQLAKKlRRRLRFSQADSGA 492
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
134-301 |
2.00e-43 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 155.00 E-value: 2.00e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQRS--AFCNIVVTQPRKIGASSIARWISKERSWTLGG 211
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPplPVANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 212 LVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRfVKVVLMSAT 291
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPD-LKVILMSAT 159
|
170
....*....|
gi 1039742015 292 INCKQFADYF 301
Cdd:cd17985 160 LNAELFSDYF 169
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
134-602 |
3.28e-41 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 162.02 E-value: 3.28e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLdhytQRSAFC-NIVVTQPRKIGASSIARWISKERSWTLGGL 212
Cdd:PRK11664 4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLL----QHGGINgKIIMLEPRRLAARNVAQRLAEQLGEKPGET 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 213 VGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATI 292
Cdd:PRK11664 80 VGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGLRDDLKLLIMSATL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 293 NCKQfadyfavpVQNKMNPAYVFEVEGKPHAIEEYYLNDLGHiyhsglpYRLEEpvitkdvyEVAVSLIQMFDdldmKES 372
Cdd:PRK11664 160 DNDR--------LQQLLPDAPVIVSEGRSFPVERRYQPLPAH-------QRFDE--------AVARATAELLR----QES 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 373 GnktwsgaqfvsersSVLVFLPGLGEINYMHELLTNMIHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESS 452
Cdd:PRK11664 213 G--------------SLLLFLPGVGEIQRVQEQLASRVASDVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETS 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 453 VTVPDVKYVIDFCLTRTLVCDEDTNYQSL---RLSWASKTscdQRKGRAGRVSKGYCYRLIPRDFWDSAiPDHVVPEMLR 529
Cdd:PRK11664 279 LTIEGIRLVVDSGLERVARFDPKTGLTRLvtqRISQASMT---QRAGRAGRLEPGICLHLYSKEQAERA-AAQSEPEILH 354
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039742015 530 CPLGSTILkvKLLDMGEPRALLATALSPPSLSDIERTILLLKEVGALAVSGQredenphdgeLTFLGRVLAQL 602
Cdd:PRK11664 355 SDLSGLLL--ELLQWGCHDPAQLSWLDQPPAAALAAAKRLLQQLGALDGQGR----------LTARGRKMAAL 415
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
134-305 |
3.13e-40 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 145.96 E-value: 3.13e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQRSAFcnIVVTQPRKIGASSIARWISKERSWTLGGLV 213
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGGM--IGITQPRRVAAVSVAKRVAEEMGVELGQLV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 214 GYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRF----VKVVLMS 289
Cdd:cd17978 79 GYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEQklspLKVIIMS 158
|
170
....*....|....*..
gi 1039742015 290 ATINCKQFADYFA-VPV 305
Cdd:cd17978 159 ATLDADLFSEYFNgAPV 175
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
134-301 |
3.18e-40 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 146.14 E-value: 3.18e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQR--SAFCNIVVTQPRKIGASSIARWISKER--SWTL 209
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERgkGSSCRIVCTQPRRISAISVAERVAAERaeSCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 210 GGLVGYQVGLE-KIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFlLLVVRKLLRTNSRFVKVVLM 288
Cdd:cd17981 81 GNSTGYQIRLEsRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDV-LMGIVKDLLPFRSDLKVILM 159
|
170
....*....|...
gi 1039742015 289 SATINCKQFADYF 301
Cdd:cd17981 160 SATLNAEKFSDYF 172
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
134-301 |
6.54e-40 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 144.94 E-value: 6.54e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYT--QRSAFCNIVVTQPRKIGASSIARWISKERSWTLGG 211
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVlrGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 212 LVGYQVGLE-KIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRfVKVVLMSA 290
Cdd:cd17976 81 NVGYQVRLEsRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPE-LRVVLMSA 159
|
170
....*....|.
gi 1039742015 291 TINCKQFADYF 301
Cdd:cd17976 160 TGDNQRLSRYF 170
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
134-301 |
2.78e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 142.28 E-value: 2.78e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQ--RSAFCNIVVTQPRKIGASSIARWISKERSWTLGG 211
Cdd:cd17972 59 LPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFIQndRAAECNIVVTQPRRISAVSVAERVAFERGEEVGK 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 212 LVGYQVGLEKIATED-TRLIYMTTGVLLQKIVSAksLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTnSRFVKVVLMSA 290
Cdd:cd17972 139 SCGYSVRFESVLPRPhASILFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVQA-YPDLRVILMSA 215
|
170
....*....|.
gi 1039742015 291 TINCKQFADYF 301
Cdd:cd17972 216 TIDTSMFCEYF 226
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
134-302 |
6.08e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 139.66 E-value: 6.08e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYT---QRSAFCNIVVTQPRKIGASSIARWISKERSWTLG 210
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLlngGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 211 -----GLVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRfVKV 285
Cdd:cd17975 81 pggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSD-LHL 159
|
170
....*....|....*..
gi 1039742015 286 VLMSATINCKQFADYFA 302
Cdd:cd17975 160 ILMSATVDCEKFSSYFT 176
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
134-301 |
1.20e-36 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 135.73 E-value: 1.20e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLV 213
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 214 GYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKS-LMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRfVKVVLMSATI 292
Cdd:cd17987 81 GYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSaLSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPN-LKLILSSAAL 159
|
....*....
gi 1039742015 293 NCKQFADYF 301
Cdd:cd17987 160 DVNLFIRYF 168
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
134-302 |
1.47e-35 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 132.57 E-value: 1.47e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDhytqrSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLV 213
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLA-----AGFRHIACTQPRRIACISLAKRVAFESLNQYGSKV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 214 GYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRfVKVVLMSATIN 293
Cdd:cd17979 76 AYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPD-LKLILMSATIN 154
|
....*....
gi 1039742015 294 CKQFADYFA 302
Cdd:cd17979 155 IELFSGYFE 163
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
134-305 |
2.13e-34 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 129.12 E-value: 2.13e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVL-DHYTQRSAfcnIVVTQPRKIGASSIARWISKERSWTLGGL 212
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHeDGYTDYGM---IGCTQPRRVAAMSVAKRVSEEMGVELGEE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 213 VGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRFvKVVLMSATI 292
Cdd:cd17983 78 VGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDL-KLIVTSATM 156
|
170
....*....|....
gi 1039742015 293 NCKQFADYFA-VPV 305
Cdd:cd17983 157 DADKFADFFGnVPI 170
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
134-301 |
1.59e-32 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 124.20 E-value: 1.59e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQRSAFcnIVVTQPRKIGASSIARWISKERSWTLGGLV 213
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGM--IGVTQPRRVAAISVAQRVAEEMKCTLGSKV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 214 GYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSR----FVKVVLMS 289
Cdd:cd17984 79 GYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSPnrkeHLKVVVMS 158
|
170
....*....|..
gi 1039742015 290 ATINCKQFADYF 301
Cdd:cd17984 159 ATLELAKLSAFF 170
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
133-301 |
5.37e-32 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 122.91 E-value: 5.37e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 133 DLPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGL 212
Cdd:cd17973 12 ELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKLVACTQPRRVAAMSVAQRVAEEMDVKLGEE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 213 VGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFlLLVVRKLLRTNSRFVKVVLMSATI 292
Cdd:cd17973 92 VGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDI-LMGLLKEVVRRRPDLKLIVMSATL 170
|
....*....
gi 1039742015 293 NCKQFADYF 301
Cdd:cd17973 171 DAGKFQKYF 179
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
134-301 |
9.69e-31 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 118.76 E-value: 9.69e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDH-YTQRSAfcNIVVTQPRKIGASSIARWISKERSWTLGGL 212
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAgYTKGGG--KIGCTQPRRVAAMSVAARVAEEMGVKLGNE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 213 VGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLlrtnSRF---VKVVLMS 289
Cdd:cd17974 79 VGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDI----ARFrpdLKLLISS 154
|
170
....*....|..
gi 1039742015 290 ATINCKQFADYF 301
Cdd:cd17974 155 ATMDAEKFSAFF 166
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
134-302 |
1.55e-30 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 118.33 E-value: 1.55e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDhyTQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLV 213
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLE--LGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGGAV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 214 GYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRtNSRFVKVVLMSATIN 293
Cdd:cd17989 79 GYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLP-RRPDLKVIITSATID 157
|
....*....
gi 1039742015 294 CKQFADYFA 302
Cdd:cd17989 158 AERFSRHFN 166
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
134-304 |
1.85e-28 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 112.83 E-value: 1.85e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDH-YTQR--SAFCNIVVTQPRKIGASSIARWISKERSwTLG 210
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAgFGSPesDNPGMIGITQPRRVAAVSMAKRVAEELN-VFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 211 GLVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDF---------LLLVVRKLLRTNSR 281
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDIligmlsrivPLRAKLYLQDQTVK 159
|
170 180
....*....|....*....|....*.
gi 1039742015 282 FVKVVLMSATINCKQFAD---YFAVP 304
Cdd:cd17982 160 PLKLVIMSATLRVEDFTEnklLFPRP 185
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
134-301 |
1.99e-27 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 109.49 E-value: 1.99e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDH-YTQRSAfcnIVVTQPRKIGASSIARWISKERSWTLGGL 212
Cdd:cd17971 6 LPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAgYTSRGK---IGCTQPRRVAAMSVAKRVAEEFGCCLGQE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 213 VGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRFvKVVLMSATI 292
Cdd:cd17971 83 VGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDL-KLIVTSATL 161
|
....*....
gi 1039742015 293 NCKQFADYF 301
Cdd:cd17971 162 DAVKFSQYF 170
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
134-310 |
1.03e-26 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 107.55 E-value: 1.03e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDH-YTqrSAFCNIVVTQPRKIGASSIARWISKERSWTLGGL 212
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAgWT--AGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLGHE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 213 VGYQVGLEKIATED-TRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRfVKVVLMSAT 291
Cdd:cd17980 79 VGYCIRFDDCTDPQaTRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGD-LRLIVASAT 157
|
170
....*....|....*....
gi 1039742015 292 INCKQFADYFAvpvQNKMN 310
Cdd:cd17980 158 LDAEKFRDFFN---QNETN 173
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
134-302 |
2.68e-25 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 103.18 E-value: 2.68e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQRSAfcNIVVTQPRKIGASSIARWISKERSWTLGGLV 213
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGG--KIIVLEPRRVAARAAARRLATLLGEAPGETV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 214 GYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATIN 293
Cdd:cd17990 79 GYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLLRDDLRLLAMSATLD 158
|
....*....
gi 1039742015 294 CKQFADYFA 302
Cdd:cd17990 159 GDGLAALLP 167
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
146-293 |
3.13e-18 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 83.70 E-value: 3.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 146 LIESNSVVIIHGATGSGKSTQLPQYVLDHYtQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLVGYQVG------L 219
Cdd:smart00487 20 LLSGLRDVILAAPTGSGKTLAALLPALEAL-KRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLYGGdskreqL 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039742015 220 EKIATEDTRLIYMTTGVLLQKIVS-AKSLMEFTHIFIDEVHeRTEEMDFLLLVVRKLLRTNSRfVKVVLMSATIN 293
Cdd:smart00487 99 RKLESGKTDILVTTPGRLLDLLENdKLSLSNVDLVILDEAH-RLLDGGFGDQLEKLLKLLPKN-VQLLLLSATPP 171
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
589-666 |
7.40e-17 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 75.77 E-value: 7.40e-17
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039742015 589 DGELTFLGRVLAQLPVSQQLGKLVVLGHVFGCLDECLIIAAALSLKNFFTMPFRQHLDGYRNKVHfsgSSRSDCLALV 666
Cdd:smart00847 8 DGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPKEKREDADAARRRFA---DPESDHLTLL 82
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
567-647 |
2.53e-16 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 74.97 E-value: 2.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 567 ILLLKEVGALavsgqreDEnphDGELTFLGRVLAQLPVSQQLGKLVVLGHVFGCLDECLIIAAALSLKNFFTMPFRQHLD 646
Cdd:pfam04408 2 LELLYYLGAL-------DE---DGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPR 71
|
.
gi 1039742015 647 G 647
Cdd:pfam04408 72 S 72
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
134-266 |
1.53e-14 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 72.24 E-value: 1.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNS-VVIIHGATGSGKSTQLPQYVLDH-YTQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGG 211
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAEFaLSRGFQKGQVTVTQPHPLAARSLALRVADEMDLNLGH 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1039742015 212 LVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMD 266
Cdd:cd17986 81 EVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASD 135
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
134-266 |
6.77e-14 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 70.62 E-value: 6.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQ----YVL-DHYTQRSAFCnivvTQPRKIGASSIARWISKERSWT 208
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQwcaeYCLsAHYQHGVVVC----TQVHKQTAVWLALRVADEMDVN 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1039742015 209 LGGLVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMD 266
Cdd:cd17977 77 IGHEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTD 134
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
404-500 |
5.06e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 62.23 E-value: 5.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 404 ELLTNMIHKR-LQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLtrtlvcdedtnyqslr 482
Cdd:smart00490 1 EELAELLKELgIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL---------------- 64
|
90
....*....|....*...
gi 1039742015 483 lsWASKTSCDQRKGRAGR 500
Cdd:smart00490 65 --PWSPASYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
384-501 |
8.60e-11 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 59.53 E-value: 8.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 384 SERSSVLVFLpglgeiNYMHELLTNMIHKR--LQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYV 461
Cdd:pfam00271 13 ERGGKVLIFS------QTKKTLEAELLLEKegIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLV 86
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1039742015 462 IDFCLTRTLvcdedtnyqslrlswaskTSCDQRKGRAGRV 501
Cdd:pfam00271 87 INYDLPWNP------------------ASYIQRIGRAGRA 108
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
150-291 |
3.19e-10 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 58.95 E-value: 3.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 150 NSVVIIHGATGSGKSTQLPQYVLDHYTQRSafCNIVVTQPRKIGASSIARWISKERSW--TLGGLVGYQ--VGLEKIATE 225
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLLKKG--KKVLVLVPTKALALQTAERLRELFGPgiRVAVLVGGSsaEEREKNKLG 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039742015 226 DTRLIYMTTGVLLQKIVSAK--SLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSAT 291
Cdd:cd00046 79 DADIIIATPDMLLNLLLREDrlFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLKNAQVILLSAT 146
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
149-507 |
1.79e-09 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 61.15 E-value: 1.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 149 SNSVVIIHGATGSGKSTQLPQ------YVLDHYTQRSAFC------NIVVTQPRKigasSIARWISKE--RSWTLGGLVG 214
Cdd:PHA02653 178 SRKPVVLTGGTGVGKTSQVPKlllwfnYLFGGFDNLDKIDpnfierPIVLSLPRV----ALVRLHSITllKSLGFDEIDG 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 215 YQVGLE--KIATEDTRLIYMTTGVLL--QKIVSAKsLMEFTHIFIDEVHERTEEMDFLLLVVRKLLrtnSRFVKVVLMSA 290
Cdd:PHA02653 254 SPISLKygSIPDELINTNPKPYGLVFstHKLTLNK-LFDYGTVIIDEVHEHDQIGDIIIAVARKHI---DKIRSLFLMTA 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 291 TI-----NCKQFADyfavpvqnkmNPAYVFEVEGKPHAIEEYYLNDLGHIYHSgLPYRLEEpviTKDVyevaVSLIQMFd 365
Cdd:PHA02653 330 TLeddrdRIKEFFP----------NPAFVHIPGGTLFPISEVYVKNKYNPKNK-RAYIEEE---KKNI----VTALKKY- 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 366 dldMKESGnktwsgaqfvserSSVLVFLPGLGEINYMHELLTNmIHKRLQVYPLHSSVTLEEQ--NNVFLSPVPgyrKII 443
Cdd:PHA02653 391 ---TPPKG-------------SSGIVFVASVSQCEEYKKYLEK-RLPIYDFYIIHGKVPNIDEilEKVYSSKNP---SII 450
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039742015 444 LSTNIAESSVTVPDVKYVIDfcLTRTLVCDEDTNYQSLrlswASKTSCDQRKGRAGRVSKG-YCY 507
Cdd:PHA02653 451 ISTPYLESSVTIRNATHVYD--TGRVYVPEPFGGKEMF----ISKSMRTQRKGRVGRVSPGtYVY 509
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
141-293 |
7.48e-08 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 52.63 E-value: 7.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 141 EEVISLIESNSVVIIHGATGSGKST--QLPqyVLDHYTQRSAFCNIVVTQPRKIGASSIARWIsKERSWTLGGLVGYQVG 218
Cdd:pfam00270 5 AEAIPAILEGRDVLVQAPTGSGKTLafLLP--ALEALDKLDNGPQALVLAPTRELAEQIYEEL-KKLGKGLGLKVASLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 219 -------LEKIATedTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHeRTEEMDFLLLVVRKLLRTNSRfVKVVLMSAT 291
Cdd:pfam00270 82 gdsrkeqLEKLKG--PDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFGPDLEEILRRLPKK-RQILLLSAT 157
|
..
gi 1039742015 292 IN 293
Cdd:pfam00270 158 LP 159
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
152-291 |
2.48e-06 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 47.93 E-value: 2.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039742015 152 VVIIHGATGSGKSTQ-LPQYVLDHYTQRSafcNIVVTQPRKIGASSIARWISKERswtlgglVGYQVGLEKIATEDTRLI 230
Cdd:cd17931 3 LTVLDLHPGAGKTTRvLPQIIREAIKKRL---RTLVLAPTRVVAAEMYEALRGLP-------IRYRTGAVKEEHGGNEIV 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039742015 231 -YMTTGVLLQKIVSAKSLMEFTHIFIDEVHerteemdFLLLVVRKLLRTNSRFVK-----VVLMSAT 291
Cdd:cd17931 73 dYMCHGTFTCRLLSPKRVPNYNLIIMDEAH-------FTDPASIAARGYIHTRVEmgeaaVIFMTAT 132
|
|
| |
