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Conserved domains on  [gi|1039768195|ref|XP_017175798|]
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origin recognition complex subunit 3 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ORC3_ins pfam19675
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ...
 214-445 6.32e-133

Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ORC subunit 3 (ORC3) located between the N-terminal AAA+-like subunit and the C-terminal winged- helix (WH) DNA-binding domain. ORC3 is a component of the origin recognition complex (ORC) that binds origins of replication, required to assemble the pre-replication complex necessary to initiate DNA replication. This domain insertion forms a bi-lobed alpha-helical protuberance that engages a short alpha-helix formed at the ORC6 C-terminal, allowing its binding to ORC1-5 subunits, which constitute the ORC core.


:

Pssm-ID: 466140  Cd Length: 233  Bit Score: 386.83  E-value: 6.32e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195 214 VNVFSVSQCENIRRLPSFRRYVENQPLGKQVALLTNETFLKEKTQSLLEDLHVYHINYFLVLRCLHNFTSSLPKYPLGRQ 293
Cdd:pfam19675   1 INSLSHDQCENIRRLPSFRRYVEKQASEKQIALLTNDRYLKEETQKLLEDLHIYHENYFPVLRCLHVFTSSLPKYPLGKQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195 294 IRELYCTCLEKKIWDSEEYKSALQLLRMLAKDELVSILQRCIEVLDSSTEKQLGNTTQKIKDFLTQFQNLDA-DSKEEED 372
Cdd:pfam19675  81 IRELYCTCLEKNIWETEEYASALQLLRMLAKDELVTLLQKCVEILKSSKGKDLGSTAKKLEEFLAQFQKLDGcENNEEEV 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039768195 373 ACGSQPKGLQKTDLYHLQKSLLEMKELRRTKKPTKFEMLRENVMNFIDNLVRDYLLPPESQPLHEVVYFSAAN 445
Cdd:pfam19675 161 TSGSQKKLQQKTDLYHLQKTLLEMKESRRSKKLTKFEVLREKVVDFIDSLVRKYLLPPETQPLHEVVYFSAAH 233
ORC3_N pfam07034
Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus ...
 3-203 1.34e-106

Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication. This domain is predicted to contain an AAA+ fold but lack the residues important for ATP hydrolysis, thus, it is called AAA+ like.


:

Pssm-ID: 462070  Cd Length: 330  Bit Score: 323.15  E-value: 1.34e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195   3 DVKHFLQKFTSQLMDCCVDRHS-----KEVTSGKALKKTNYSMDSLCSWYSAVTQKADHKVTIKKRTASG-HWRSPPVVL 76
Cdd:pfam07034 124 ALKHALQKVLSQLMGCEVDVDSdeeeeEEESDTKSLRKSQCSMRALCSWYAEVTRKTSPRSRPKKRASSArKIQSPPVVV 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195  77 ILKSMESFTSKVLQDFITISSQHLHEFPLILIFGIATSPVIIHRLLPHSVSSLLCVELFQSLSCEQHLTVVLDKLLLTPQ 156
Cdd:pfam07034 204 IFKDLESFSAKVLQDFILILSSYLSELPLVFVFGVATSPSAVHRMLPHSVSSLLCIELFQSLSCTSHLAEVLDKVLLTPQ 283

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1039768195 157 FPFKLSKKALQVLTNIFLYHDFSIQSFIKGIKLSLLEHFYSQPLSVL 203
Cdd:pfam07034 284 FPFKLSGKVLQVLTHIFLYHDFSVQNFIKGLQLALLEHFYSQPLSVL 330
Orc3 cd20704
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit ...
 434-565 2.72e-54

Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit of the heterohexameric origin recognition complex (ORC) that is essential for coordinating replication onset. ORC binds to the origin of replication, binds CDC6, and recruits the hexameric MCM2-7 ring to the DNA, which leads to the assembly of the pre-replicative complex (pre-RC). Five of the 6 ORC subunits (Orc 1-5) retain AAA+ (ATPases associated with a variety of cellular activities) folds, but Orc3, as well as Orc2, lost their ATP-binding signatures.


:

Pssm-ID: 412052 [Multi-domain]  Cd Length: 387  Bit Score: 188.54  E-value: 2.72e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195 434 PLHEVVYFSAANTLREHLNAAPRIALHTALNNPYYYLKNE----ELEGCIPNTAPDICIAYKLHLECSLLINLVDWAEAF 509
Cdd:cd20704   242 PLHEIFYFDDVSPLRSALIPSPRAAIETALLNPHDYLQCEccksDDDGLILSTLPDTSILYKLYLESGRLINVYDWYQAF 321

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039768195 510 ATVVTAAEKMD----------ANSTVSEEMSEVIHARFIRAVSELELLGFIKPTKQKTDHVARLTW 565
Cdd:cd20704   322 KTVLEPEEEEEkekkesseekEDEEDEEEWEKELQARFIRAVAELQFLGFIKPTKRKTDHVARLTW 387
 
Name Accession Description Interval E-value
ORC3_ins pfam19675
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ...
 214-445 6.32e-133

Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ORC subunit 3 (ORC3) located between the N-terminal AAA+-like subunit and the C-terminal winged- helix (WH) DNA-binding domain. ORC3 is a component of the origin recognition complex (ORC) that binds origins of replication, required to assemble the pre-replication complex necessary to initiate DNA replication. This domain insertion forms a bi-lobed alpha-helical protuberance that engages a short alpha-helix formed at the ORC6 C-terminal, allowing its binding to ORC1-5 subunits, which constitute the ORC core.


Pssm-ID: 466140  Cd Length: 233  Bit Score: 386.83  E-value: 6.32e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195 214 VNVFSVSQCENIRRLPSFRRYVENQPLGKQVALLTNETFLKEKTQSLLEDLHVYHINYFLVLRCLHNFTSSLPKYPLGRQ 293
Cdd:pfam19675   1 INSLSHDQCENIRRLPSFRRYVEKQASEKQIALLTNDRYLKEETQKLLEDLHIYHENYFPVLRCLHVFTSSLPKYPLGKQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195 294 IRELYCTCLEKKIWDSEEYKSALQLLRMLAKDELVSILQRCIEVLDSSTEKQLGNTTQKIKDFLTQFQNLDA-DSKEEED 372
Cdd:pfam19675  81 IRELYCTCLEKNIWETEEYASALQLLRMLAKDELVTLLQKCVEILKSSKGKDLGSTAKKLEEFLAQFQKLDGcENNEEEV 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039768195 373 ACGSQPKGLQKTDLYHLQKSLLEMKELRRTKKPTKFEMLRENVMNFIDNLVRDYLLPPESQPLHEVVYFSAAN 445
Cdd:pfam19675 161 TSGSQKKLQQKTDLYHLQKTLLEMKESRRSKKLTKFEVLREKVVDFIDSLVRKYLLPPETQPLHEVVYFSAAH 233
ORC3_N pfam07034
Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus ...
 3-203 1.34e-106

Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication. This domain is predicted to contain an AAA+ fold but lack the residues important for ATP hydrolysis, thus, it is called AAA+ like.


Pssm-ID: 462070  Cd Length: 330  Bit Score: 323.15  E-value: 1.34e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195   3 DVKHFLQKFTSQLMDCCVDRHS-----KEVTSGKALKKTNYSMDSLCSWYSAVTQKADHKVTIKKRTASG-HWRSPPVVL 76
Cdd:pfam07034 124 ALKHALQKVLSQLMGCEVDVDSdeeeeEEESDTKSLRKSQCSMRALCSWYAEVTRKTSPRSRPKKRASSArKIQSPPVVV 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195  77 ILKSMESFTSKVLQDFITISSQHLHEFPLILIFGIATSPVIIHRLLPHSVSSLLCVELFQSLSCEQHLTVVLDKLLLTPQ 156
Cdd:pfam07034 204 IFKDLESFSAKVLQDFILILSSYLSELPLVFVFGVATSPSAVHRMLPHSVSSLLCIELFQSLSCTSHLAEVLDKVLLTPQ 283

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1039768195 157 FPFKLSKKALQVLTNIFLYHDFSIQSFIKGIKLSLLEHFYSQPLSVL 203
Cdd:pfam07034 284 FPFKLSGKVLQVLTHIFLYHDFSVQNFIKGLQLALLEHFYSQPLSVL 330
Orc3 cd20704
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit ...
 434-565 2.72e-54

Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit of the heterohexameric origin recognition complex (ORC) that is essential for coordinating replication onset. ORC binds to the origin of replication, binds CDC6, and recruits the hexameric MCM2-7 ring to the DNA, which leads to the assembly of the pre-replicative complex (pre-RC). Five of the 6 ORC subunits (Orc 1-5) retain AAA+ (ATPases associated with a variety of cellular activities) folds, but Orc3, as well as Orc2, lost their ATP-binding signatures.


Pssm-ID: 412052 [Multi-domain]  Cd Length: 387  Bit Score: 188.54  E-value: 2.72e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195 434 PLHEVVYFSAANTLREHLNAAPRIALHTALNNPYYYLKNE----ELEGCIPNTAPDICIAYKLHLECSLLINLVDWAEAF 509
Cdd:cd20704   242 PLHEIFYFDDVSPLRSALIPSPRAAIETALLNPHDYLQCEccksDDDGLILSTLPDTSILYKLYLESGRLINVYDWYQAF 321

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039768195 510 ATVVTAAEKMD----------ANSTVSEEMSEVIHARFIRAVSELELLGFIKPTKQKTDHVARLTW 565
Cdd:cd20704   322 KTVLEPEEEEEkekkesseekEDEEDEEEWEKELQARFIRAVAELQFLGFIKPTKRKTDHVARLTW 387
Orc3 cd20704
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit ...
 73-203 3.56e-54

Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit of the heterohexameric origin recognition complex (ORC) that is essential for coordinating replication onset. ORC binds to the origin of replication, binds CDC6, and recruits the hexameric MCM2-7 ring to the DNA, which leads to the assembly of the pre-replicative complex (pre-RC). Five of the 6 ORC subunits (Orc 1-5) retain AAA+ (ATPases associated with a variety of cellular activities) folds, but Orc3, as well as Orc2, lost their ATP-binding signatures.


Pssm-ID: 412052 [Multi-domain]  Cd Length: 387  Bit Score: 188.15  E-value: 3.56e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195  73 PVVLILKSMESFTSKVLQDFITISSQHLHEFPLILIFGIATSPVIIHRLLPHSVSSLLCVELFQSLSCEQHLTVVLDKLL 152
Cdd:cd20704   111 PLVVILEDFESFDPSVLQDLILILSSYLDRLPFVLIFGIATSVEAFHKRLPRSTLSLLRIEKFQLPSSSDYLERVLEKVL 190

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1039768195 153 LTPQFPFKLSKKALQVLTNIFLYHDFSIQSFIKGIKLSLLEHFYSQPLSVL 203
Cdd:cd20704   191 LDPDPPLKLGPKVLEFLLDRFLRHDFSVDSFISALKYAYMEHFYANPLSIL 241
ORC_WH_C pfam18137
Origin recognition complex winged helix C-terminal; This is the C-terminal winged-helix (WH) ...
 456-565 2.41e-37

Origin recognition complex winged helix C-terminal; This is the C-terminal winged-helix (WH) DNA-binding domain of the origin recognition complex present in Drosophila melanogaster. The WH domain is responsible for recognizing origin sequences.


Pssm-ID: 436299  Cd Length: 131  Bit Score: 134.74  E-value: 2.41e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195 456 RIALHTALNNPYYYLKNE----ELEGCIPNTAPDICIAYKLHLECSLLINLVDWAEAFATVVTAAEKMDANSTVS----- 526
Cdd:pfam18137   1 RSTIESALLNPEDYLRCEccddSEEELSLASLPDTSILFKLYLEAGRLINLYDWYQAFKEVLEKEEELVRLREAAkegkd 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1039768195 527 ------------EEMSEVIHARFIRAVSELELLGFIKPTKQKTDHVARLTW 565
Cdd:pfam18137  81 kdaekdadeeddEEWEKELQARFLRALAELQYLGFIKHTKRKTDHVEKTIW 131
 
Name Accession Description Interval E-value
ORC3_ins pfam19675
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ...
 214-445 6.32e-133

Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ORC subunit 3 (ORC3) located between the N-terminal AAA+-like subunit and the C-terminal winged- helix (WH) DNA-binding domain. ORC3 is a component of the origin recognition complex (ORC) that binds origins of replication, required to assemble the pre-replication complex necessary to initiate DNA replication. This domain insertion forms a bi-lobed alpha-helical protuberance that engages a short alpha-helix formed at the ORC6 C-terminal, allowing its binding to ORC1-5 subunits, which constitute the ORC core.


Pssm-ID: 466140  Cd Length: 233  Bit Score: 386.83  E-value: 6.32e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195 214 VNVFSVSQCENIRRLPSFRRYVENQPLGKQVALLTNETFLKEKTQSLLEDLHVYHINYFLVLRCLHNFTSSLPKYPLGRQ 293
Cdd:pfam19675   1 INSLSHDQCENIRRLPSFRRYVEKQASEKQIALLTNDRYLKEETQKLLEDLHIYHENYFPVLRCLHVFTSSLPKYPLGKQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195 294 IRELYCTCLEKKIWDSEEYKSALQLLRMLAKDELVSILQRCIEVLDSSTEKQLGNTTQKIKDFLTQFQNLDA-DSKEEED 372
Cdd:pfam19675  81 IRELYCTCLEKNIWETEEYASALQLLRMLAKDELVTLLQKCVEILKSSKGKDLGSTAKKLEEFLAQFQKLDGcENNEEEV 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039768195 373 ACGSQPKGLQKTDLYHLQKSLLEMKELRRTKKPTKFEMLRENVMNFIDNLVRDYLLPPESQPLHEVVYFSAAN 445
Cdd:pfam19675 161 TSGSQKKLQQKTDLYHLQKTLLEMKESRRSKKLTKFEVLREKVVDFIDSLVRKYLLPPETQPLHEVVYFSAAH 233
ORC3_N pfam07034
Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus ...
 3-203 1.34e-106

Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication. This domain is predicted to contain an AAA+ fold but lack the residues important for ATP hydrolysis, thus, it is called AAA+ like.


Pssm-ID: 462070  Cd Length: 330  Bit Score: 323.15  E-value: 1.34e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195   3 DVKHFLQKFTSQLMDCCVDRHS-----KEVTSGKALKKTNYSMDSLCSWYSAVTQKADHKVTIKKRTASG-HWRSPPVVL 76
Cdd:pfam07034 124 ALKHALQKVLSQLMGCEVDVDSdeeeeEEESDTKSLRKSQCSMRALCSWYAEVTRKTSPRSRPKKRASSArKIQSPPVVV 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195  77 ILKSMESFTSKVLQDFITISSQHLHEFPLILIFGIATSPVIIHRLLPHSVSSLLCVELFQSLSCEQHLTVVLDKLLLTPQ 156
Cdd:pfam07034 204 IFKDLESFSAKVLQDFILILSSYLSELPLVFVFGVATSPSAVHRMLPHSVSSLLCIELFQSLSCTSHLAEVLDKVLLTPQ 283

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1039768195 157 FPFKLSKKALQVLTNIFLYHDFSIQSFIKGIKLSLLEHFYSQPLSVL 203
Cdd:pfam07034 284 FPFKLSGKVLQVLTHIFLYHDFSVQNFIKGLQLALLEHFYSQPLSVL 330
Orc3 cd20704
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit ...
 434-565 2.72e-54

Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit of the heterohexameric origin recognition complex (ORC) that is essential for coordinating replication onset. ORC binds to the origin of replication, binds CDC6, and recruits the hexameric MCM2-7 ring to the DNA, which leads to the assembly of the pre-replicative complex (pre-RC). Five of the 6 ORC subunits (Orc 1-5) retain AAA+ (ATPases associated with a variety of cellular activities) folds, but Orc3, as well as Orc2, lost their ATP-binding signatures.


Pssm-ID: 412052 [Multi-domain]  Cd Length: 387  Bit Score: 188.54  E-value: 2.72e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195 434 PLHEVVYFSAANTLREHLNAAPRIALHTALNNPYYYLKNE----ELEGCIPNTAPDICIAYKLHLECSLLINLVDWAEAF 509
Cdd:cd20704   242 PLHEIFYFDDVSPLRSALIPSPRAAIETALLNPHDYLQCEccksDDDGLILSTLPDTSILYKLYLESGRLINVYDWYQAF 321

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039768195 510 ATVVTAAEKMD----------ANSTVSEEMSEVIHARFIRAVSELELLGFIKPTKQKTDHVARLTW 565
Cdd:cd20704   322 KTVLEPEEEEEkekkesseekEDEEDEEEWEKELQARFIRAVAELQFLGFIKPTKRKTDHVARLTW 387
Orc3 cd20704
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit ...
 73-203 3.56e-54

Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit of the heterohexameric origin recognition complex (ORC) that is essential for coordinating replication onset. ORC binds to the origin of replication, binds CDC6, and recruits the hexameric MCM2-7 ring to the DNA, which leads to the assembly of the pre-replicative complex (pre-RC). Five of the 6 ORC subunits (Orc 1-5) retain AAA+ (ATPases associated with a variety of cellular activities) folds, but Orc3, as well as Orc2, lost their ATP-binding signatures.


Pssm-ID: 412052 [Multi-domain]  Cd Length: 387  Bit Score: 188.15  E-value: 3.56e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195  73 PVVLILKSMESFTSKVLQDFITISSQHLHEFPLILIFGIATSPVIIHRLLPHSVSSLLCVELFQSLSCEQHLTVVLDKLL 152
Cdd:cd20704   111 PLVVILEDFESFDPSVLQDLILILSSYLDRLPFVLIFGIATSVEAFHKRLPRSTLSLLRIEKFQLPSSSDYLERVLEKVL 190

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1039768195 153 LTPQFPFKLSKKALQVLTNIFLYHDFSIQSFIKGIKLSLLEHFYSQPLSVL 203
Cdd:cd20704   191 LDPDPPLKLGPKVLEFLLDRFLRHDFSVDSFISALKYAYMEHFYANPLSIL 241
ORC_WH_C pfam18137
Origin recognition complex winged helix C-terminal; This is the C-terminal winged-helix (WH) ...
 456-565 2.41e-37

Origin recognition complex winged helix C-terminal; This is the C-terminal winged-helix (WH) DNA-binding domain of the origin recognition complex present in Drosophila melanogaster. The WH domain is responsible for recognizing origin sequences.


Pssm-ID: 436299  Cd Length: 131  Bit Score: 134.74  E-value: 2.41e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768195 456 RIALHTALNNPYYYLKNE----ELEGCIPNTAPDICIAYKLHLECSLLINLVDWAEAFATVVTAAEKMDANSTVS----- 526
Cdd:pfam18137   1 RSTIESALLNPEDYLRCEccddSEEELSLASLPDTSILFKLYLEAGRLINLYDWYQAFKEVLEKEEELVRLREAAkegkd 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1039768195 527 ------------EEMSEVIHARFIRAVSELELLGFIKPTKQKTDHVARLTW 565
Cdd:pfam18137  81 kdaekdadeeddEEWEKELQARFLRALAELQYLGFIKHTKRKTDHVEKTIW 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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