nuclear factor of activated T-cells, cytoplasmic 3 isoform X5 [Callithrix jacchus]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| RHD-n_NFAT | cd07881 | N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ... |
421-594 | 5.43e-131 | ||||
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development. : Pssm-ID: 143641 Cd Length: 175 Bit Score: 384.93 E-value: 5.43e-131
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| IPT_NFAT | cd01178 | IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ... |
599-699 | 9.52e-59 | ||||
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction. : Pssm-ID: 238583 Cd Length: 101 Bit Score: 193.47 E-value: 9.52e-59
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| KLF6_7_N-like super family | cl41732 | N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins; This subfamily ... |
237-308 | 8.15e-04 | ||||
N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 6, KLF7, and similar proteins, including KLF Luna, a Drosophila KLF6/KLF7. KLF6 contributes to cell proliferation, differentiation, cell death and signal transduction. Hepatocyte expression of KLF6 regulates hepatic fatty acid and glucose metabolism via transcriptional activation of liver glucokinase and post-transcriptional regulation of the nuclear receptor peroxisome proliferator activated receptor alpha (PPARa). KLF7 is involved in regulation of the development and function of the nervous system and adipose tissue, type 2 diabetes, blood diseases, as well as pluripotent cell maintenance. KLF Luna is maternally required for synchronized nuclear and centrosome cycles in the preblastoderm embryo. KLF6 and KLF7 are transcriptional activators. They belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF6, KLF7, and similar proteins. The actual alignment was detected with superfamily member cd21973: Pssm-ID: 425363 [Multi-domain] Cd Length: 138 Bit Score: 40.34 E-value: 8.15e-04
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| Name | Accession | Description | Interval | E-value | ||||
| RHD-n_NFAT | cd07881 | N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ... |
421-594 | 5.43e-131 | ||||
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development. Pssm-ID: 143641 Cd Length: 175 Bit Score: 384.93 E-value: 5.43e-131
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| IPT_NFAT | cd01178 | IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ... |
599-699 | 9.52e-59 | ||||
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction. Pssm-ID: 238583 Cd Length: 101 Bit Score: 193.47 E-value: 9.52e-59
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| RHD_dimer | pfam16179 | Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural ... |
602-700 | 5.25e-34 | ||||
Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain. Pssm-ID: 465045 Cd Length: 102 Bit Score: 125.37 E-value: 5.25e-34
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| RHD_DNA_bind | pfam00554 | Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are ... |
433-592 | 1.17e-30 | ||||
Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain. Pssm-ID: 425749 Cd Length: 169 Bit Score: 118.18 E-value: 1.17e-30
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| IPT | smart00429 | ig-like, plexins, transcription factors; |
599-698 | 1.35e-13 | ||||
ig-like, plexins, transcription factors; Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 66.68 E-value: 1.35e-13
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| KLF6_7_N-like | cd21973 | N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins; This subfamily ... |
237-308 | 8.15e-04 | ||||
N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 6, KLF7, and similar proteins, including KLF Luna, a Drosophila KLF6/KLF7. KLF6 contributes to cell proliferation, differentiation, cell death and signal transduction. Hepatocyte expression of KLF6 regulates hepatic fatty acid and glucose metabolism via transcriptional activation of liver glucokinase and post-transcriptional regulation of the nuclear receptor peroxisome proliferator activated receptor alpha (PPARa). KLF7 is involved in regulation of the development and function of the nervous system and adipose tissue, type 2 diabetes, blood diseases, as well as pluripotent cell maintenance. KLF Luna is maternally required for synchronized nuclear and centrosome cycles in the preblastoderm embryo. KLF6 and KLF7 are transcriptional activators. They belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF6, KLF7, and similar proteins. Pssm-ID: 409246 [Multi-domain] Cd Length: 138 Bit Score: 40.34 E-value: 8.15e-04
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| Name | Accession | Description | Interval | E-value | ||||
| RHD-n_NFAT | cd07881 | N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ... |
421-594 | 5.43e-131 | ||||
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development. Pssm-ID: 143641 Cd Length: 175 Bit Score: 384.93 E-value: 5.43e-131
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| RHD-n_NFAT_like | cd07927 | N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ... |
432-593 | 4.91e-71 | ||||
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins and similar proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development. This group also contains the N-terminal RHD sub-domain of the non-calcium regulated tonicity-responsive enhancer binding protein (TonEBP), also called NFAT5. Mammalian TonEBP regulates the expression of genes in response to tonicity. It plays a pivotal role in urinary concentrating mechanisms in kidney medulla, by triggering the accumulation of osmolytes that enable renal medullary cells to tolerate high levels of urea and salt. Pssm-ID: 143648 Cd Length: 161 Bit Score: 228.70 E-value: 4.91e-71
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| RHD-n_TonEBP | cd07882 | N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding ... |
431-593 | 2.84e-61 | ||||
N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the tonicity-responsive enhancer binding protein (TonEBP), also called NFAT5. Mammalian TonEBP regulates the expression of genes in response to tonicity. It plays a pivotal role in urinary concentrating mechanisms in kidney medulla, by triggering the accumulation of osmolytes that enable renal medullary cells to tolerate high levels of urea and salt. Pssm-ID: 143642 Cd Length: 161 Bit Score: 202.74 E-value: 2.84e-61
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| IPT_NFAT | cd01178 | IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ... |
599-699 | 9.52e-59 | ||||
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction. Pssm-ID: 238583 Cd Length: 101 Bit Score: 193.47 E-value: 9.52e-59
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| IPT_TF | cd00602 | IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated ... |
600-699 | 3.71e-36 | ||||
IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region. Pssm-ID: 238336 Cd Length: 101 Bit Score: 131.25 E-value: 3.71e-36
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| RHD-n | cd07827 | N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology ... |
432-593 | 1.81e-35 | ||||
N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel). Pssm-ID: 143640 Cd Length: 174 Bit Score: 132.11 E-value: 1.81e-35
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| RHD_dimer | pfam16179 | Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural ... |
602-700 | 5.25e-34 | ||||
Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain. Pssm-ID: 465045 Cd Length: 102 Bit Score: 125.37 E-value: 5.25e-34
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| RHD_DNA_bind | pfam00554 | Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are ... |
433-592 | 1.17e-30 | ||||
Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain. Pssm-ID: 425749 Cd Length: 169 Bit Score: 118.18 E-value: 1.17e-30
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| IPT | smart00429 | ig-like, plexins, transcription factors; |
599-698 | 1.35e-13 | ||||
ig-like, plexins, transcription factors; Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 66.68 E-value: 1.35e-13
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| IPT | cd00102 | Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ... |
600-699 | 2.24e-09 | ||||
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers. Pssm-ID: 238050 [Multi-domain] Cd Length: 89 Bit Score: 54.77 E-value: 2.24e-09
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| KLF6_7_N-like | cd21973 | N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins; This subfamily ... |
237-308 | 8.15e-04 | ||||
N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 6, KLF7, and similar proteins, including KLF Luna, a Drosophila KLF6/KLF7. KLF6 contributes to cell proliferation, differentiation, cell death and signal transduction. Hepatocyte expression of KLF6 regulates hepatic fatty acid and glucose metabolism via transcriptional activation of liver glucokinase and post-transcriptional regulation of the nuclear receptor peroxisome proliferator activated receptor alpha (PPARa). KLF7 is involved in regulation of the development and function of the nervous system and adipose tissue, type 2 diabetes, blood diseases, as well as pluripotent cell maintenance. KLF Luna is maternally required for synchronized nuclear and centrosome cycles in the preblastoderm embryo. KLF6 and KLF7 are transcriptional activators. They belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF6, KLF7, and similar proteins. Pssm-ID: 409246 [Multi-domain] Cd Length: 138 Bit Score: 40.34 E-value: 8.15e-04
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| IPT_NFkappaB | cd01177 | IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is ... |
608-699 | 6.82e-03 | ||||
IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation. Pssm-ID: 238582 Cd Length: 102 Bit Score: 36.91 E-value: 6.82e-03
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| Blast search parameters | ||||
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