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Conserved domains on  [gi|1069398702|ref|XP_018094660|]
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brain protein I3 [Xenopus laevis]

Protein Classification

brain protein I3( domain architecture ID 10562754)

brain protein I3 is a DUF2367 domain-containing protein that participates in tumor necrosis factor-alpha (TNF)-induced cell death

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BRI3 pfam10164
Brain protein I3; This is a highly conserved family of proteins which contains three pairs of ...
 29-133 2.09e-36

Brain protein I3; This is a highly conserved family of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N-terminus. It includes a membrane protein that has been found to be highly expressed in the mouse brain and consequently, several members have been assigned as brain protein I3 (Bri3). Their function is unknown but they appear to play a role in TNF-induced cell death.


:

Pssm-ID: 431102  Cd Length: 104  Bit Score: 120.40  E-value: 2.09e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069398702  29 NYGTIPGAPQTAAQPAYPPAYPYPAASGYAP-SSQLAYPGTYTIIQQPaaTTSVVVVGGCPACRVGVLEDSFTCLGLFCA 107
Cdd:pfam10164   1 GYGAIPTAPPQYLITYVVTQAPPPYQYPDGPaVSQQPQQTTYTIVVQP--TQSVVVVGGCPACRVGVLEDDFTCLGILCA 78

                          90       100
                  ....*....|....*....|....*.
gi 1069398702 108 IFFFPIGILFCLALRQRRCPNCGATF 133
Cdd:pfam10164  79 IFFFPIGILCCLAMRQRRCPNCGATF 104
 
Name Accession Description Interval E-value
BRI3 pfam10164
Brain protein I3; This is a highly conserved family of proteins which contains three pairs of ...
 29-133 2.09e-36

Brain protein I3; This is a highly conserved family of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N-terminus. It includes a membrane protein that has been found to be highly expressed in the mouse brain and consequently, several members have been assigned as brain protein I3 (Bri3). Their function is unknown but they appear to play a role in TNF-induced cell death.


Pssm-ID: 431102  Cd Length: 104  Bit Score: 120.40  E-value: 2.09e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069398702  29 NYGTIPGAPQTAAQPAYPPAYPYPAASGYAP-SSQLAYPGTYTIIQQPaaTTSVVVVGGCPACRVGVLEDSFTCLGLFCA 107
Cdd:pfam10164   1 GYGAIPTAPPQYLITYVVTQAPPPYQYPDGPaVSQQPQQTTYTIVVQP--TQSVVVVGGCPACRVGVLEDDFTCLGILCA 78

                          90       100
                  ....*....|....*....|....*.
gi 1069398702 108 IFFFPIGILFCLALRQRRCPNCGATF 133
Cdd:pfam10164  79 IFFFPIGILCCLAMRQRRCPNCGATF 104
RING-HC_dBre1-like cd16705
RING finger, HC subclass, found in Drosophila melanogaster Bre1 (dBre1) and similar proteins; ...
 87-134 1.13e-03

RING finger, HC subclass, found in Drosophila melanogaster Bre1 (dBre1) and similar proteins; dBre1 is the functional homolog of yeast Bre1, an E3 ubiquitin ligase required for the monoubiquitination of histone H2B and, indirectly, for H3K4 methylation. dBre1 acts as a nuclear component required for the expression of Notch target genes in Drosophila development. dBre1 contains a C3HC4-type RING-HC finger at its C-terminus.


Pssm-ID: 438365 [Multi-domain]  Cd Length: 69  Bit Score: 35.32  E-value: 1.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1069398702  87 CPACRVGVLEDSFT-CLGLFCaifffpigiLFCL----ALRQRRCPNCGATFG 134
Cdd:cd16705    17 CPSCKVKRKDAVLTkCFHVFC---------LDCLrtryETRQRKCPKCNAAFG 60
 
Name Accession Description Interval E-value
BRI3 pfam10164
Brain protein I3; This is a highly conserved family of proteins which contains three pairs of ...
 29-133 2.09e-36

Brain protein I3; This is a highly conserved family of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N-terminus. It includes a membrane protein that has been found to be highly expressed in the mouse brain and consequently, several members have been assigned as brain protein I3 (Bri3). Their function is unknown but they appear to play a role in TNF-induced cell death.


Pssm-ID: 431102  Cd Length: 104  Bit Score: 120.40  E-value: 2.09e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069398702  29 NYGTIPGAPQTAAQPAYPPAYPYPAASGYAP-SSQLAYPGTYTIIQQPaaTTSVVVVGGCPACRVGVLEDSFTCLGLFCA 107
Cdd:pfam10164   1 GYGAIPTAPPQYLITYVVTQAPPPYQYPDGPaVSQQPQQTTYTIVVQP--TQSVVVVGGCPACRVGVLEDDFTCLGILCA 78

                          90       100
                  ....*....|....*....|....*.
gi 1069398702 108 IFFFPIGILFCLALRQRRCPNCGATF 133
Cdd:pfam10164  79 IFFFPIGILCCLAMRQRRCPNCGATF 104
RING-HC_dBre1-like cd16705
RING finger, HC subclass, found in Drosophila melanogaster Bre1 (dBre1) and similar proteins; ...
 87-134 1.13e-03

RING finger, HC subclass, found in Drosophila melanogaster Bre1 (dBre1) and similar proteins; dBre1 is the functional homolog of yeast Bre1, an E3 ubiquitin ligase required for the monoubiquitination of histone H2B and, indirectly, for H3K4 methylation. dBre1 acts as a nuclear component required for the expression of Notch target genes in Drosophila development. dBre1 contains a C3HC4-type RING-HC finger at its C-terminus.


Pssm-ID: 438365 [Multi-domain]  Cd Length: 69  Bit Score: 35.32  E-value: 1.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1069398702  87 CPACRVGVLEDSFT-CLGLFCaifffpigiLFCL----ALRQRRCPNCGATFG 134
Cdd:cd16705    17 CPSCKVKRKDAVLTkCFHVFC---------LDCLrtryETRQRKCPKCNAAFG 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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