NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1117252054|ref|XP_019383813|]
View 

PREDICTED: zinc finger protein 585A-like isoform X2 [Gavialis gangeticus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12029796)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription; also contains a SCAN domain; similar to Homo sapiens zinc finger protein 483

CATH:  3.30.160.60|1.10.287.1360|1.10.4020.10
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247|10567577|10747874
SCOP:  4003583|4002243|4001237

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 93-173 1.37e-27

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


:

Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 107.19  E-value: 1.37e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054   93 PETWCQRFRSFHYQEAEGAQEICSHLQELCQHCLEPQHRSKEQI--LVVLEQILAILPQEMQSLQWESGAETC------A 164
Cdd:pfam02023    1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQIleLLVLEQFLTILPEEIQSWVREHHPESGeeavalA 80


                   ....*....
gi 1117252054  165 EEFQLEQAE 173
Cdd:pfam02023   81 EDLLLERGE 89
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
891-1243 3.60e-20

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 95.53  E-value: 3.60e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  891 KPHQCSVCGKSFTQSPHLTQHQRIHTGEKPHQCPV--CGKSFGQSSTLAQHQRIHTGEKPHLCSVCGKS----------- 957
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnskassssls 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  958 ---------------------------FSRSSTLARHQLIHTG---------------EKPHHCSACGKSFTQSSHLaqH 995
Cdd:COG5048    112 ssssnsndnnllsshslppssrdpqlpDLLSISNLRNNPLPGNnsssvntpqsnslhpPLPANSLSKDPSSNLSLLI--S 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  996 QRIHTGEKPHQCSVCGKGFIHSSRLAEHQHIHTGEKPHQCSVCGKCFTQSSSLAKHQHLHTGEKPHQCPECGKSFSCSST 1075
Cdd:COG5048    190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054 1076 LAQHQLIHTGE-------KPHQCPVCGKSFSRSSTLVRHQR--IHTGE--KPHQCFV--CGKSFTQSSILVQHQRIHTGE 1142
Cdd:COG5048    270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054 1143 KPHQCSECGKSFTHSSSL-------AQHHRIHTGEKPHQCSV--CGKSFTQSSNLAKHQRIHTGEKPHQC--SVCGKSFT 1211
Cdd:COG5048    350 SPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                          410       420       430
                   ....*....|....*....|....*....|..
gi 1117252054 1212 QSSNLAKHQRIHTGEKSHQCSECGKSFSCSST 1243
Cdd:COG5048    430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
KRAB smart00349
krueppel associated box;
314-373 2.34e-19

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.03  E-value: 2.34e-19
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054   314 FEDVAVYFTRKEWELLEDEDKGLYRDQMLRNYQALISLGYRGPTPDLIYRIQRGQvELWV 373
Cdd:smart00349    3 FEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGE-EPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
546-968 4.85e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 4.85e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  546 KPHICAICGKSFTCLLTLAAHCKSHSGELPYRCTKCEHSFVCSLDLAKHQHV--HREKHQYRCVTCSKTFTYFSSLAQHR 623
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLrtHHNNPSDLNSKSLPLSNSKASSSSLS 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  624 RIHLGRKTHhctkcrkNLICWQDLSQHRCVKKADKPHHYTKCGKSFRQPSNMARHTLMQTGENNQLTCIGEKPHQCSVCG 703
Cdd:COG5048    112 SSSSNSNDN-------NLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNL 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  704 KSFTQPSHLAKHQCIHtgEKLHQFPERGKSFSCSTSLAQYQcihtgEKPYLCSDCGKSFTHPSHLAKHQLIHTGEKPHQC 783
Cdd:COG5048    185 SLLISSNVSTSIPSSS--ENSPLSSSYSIPSSSSDQNLENS-----SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  784 SVCGKSFTQSPHLTQHQRIHTGE-------KPHQCSVCGKSFTQSPHLTQHQR--IHTGE--KPHQC--SVCGKSFTQSP 850
Cdd:COG5048    258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRND 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  851 HLTQHQRIHTGEKPHQC--SVCGKSFTQSPH-----LTQHQRIHTGEKPHQCSV--CGKSFTQSPHLTQHQRIHTGEKPH 921
Cdd:COG5048    338 ALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPY 417

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 1117252054  922 QC--PVCGKSFGQSSTLAQHQRIHTGEKPHLCSVCGKSFSRSSTLARHQ 968
Cdd:COG5048    418 NCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 93-173 1.37e-27

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 107.19  E-value: 1.37e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054   93 PETWCQRFRSFHYQEAEGAQEICSHLQELCQHCLEPQHRSKEQI--LVVLEQILAILPQEMQSLQWESGAETC------A 164
Cdd:pfam02023    1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQIleLLVLEQFLTILPEEIQSWVREHHPESGeeavalA 80


                   ....*....
gi 1117252054  165 EEFQLEQAE 173
Cdd:pfam02023   81 EDLLLERGE 89
SCAN smart00431
leucine rich region;
93-198 2.36e-21

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 90.44  E-value: 2.36e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054    93 PETWCQRFRSFHYQEAEGAQEICSHLQELCQHCLEPQHRSKEQI--LVVLEQILAILPQEMQS---LQW-ESGAE--TCA 164
Cdd:smart00431    1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQIleLLVLEQFLTILPGELQAwvrEHHpESGEEavTLL 80

                            90       100       110
                    ....*....|....*....|....*....|....
gi 1117252054   165 EEFQLEqAEDNKLQVTVNVKVEEVSSDEMQPTGA 198
Cdd:smart00431   81 EDLERE-LDEPGQQVSAHVHGQEVLLEKMVPLGA 113
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 93-165 2.82e-20

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 86.55  E-value: 2.82e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1117252054   93 PETWCQRFRSFHYQEAEGAQEICSHLQELCQHCLEPQHRSKEQIL--VVLEQILAILPQEMQSLQWESGAETCAE 165
Cdd:cd07936      1 PETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILelLVLEQFLIILPPEVQAWVRERKPESGEE 75
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
891-1243 3.60e-20

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 95.53  E-value: 3.60e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  891 KPHQCSVCGKSFTQSPHLTQHQRIHTGEKPHQCPV--CGKSFGQSSTLAQHQRIHTGEKPHLCSVCGKS----------- 957
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnskassssls 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  958 ---------------------------FSRSSTLARHQLIHTG---------------EKPHHCSACGKSFTQSSHLaqH 995
Cdd:COG5048    112 ssssnsndnnllsshslppssrdpqlpDLLSISNLRNNPLPGNnsssvntpqsnslhpPLPANSLSKDPSSNLSLLI--S 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  996 QRIHTGEKPHQCSVCGKGFIHSSRLAEHQHIHTGEKPHQCSVCGKCFTQSSSLAKHQHLHTGEKPHQCPECGKSFSCSST 1075
Cdd:COG5048    190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054 1076 LAQHQLIHTGE-------KPHQCPVCGKSFSRSSTLVRHQR--IHTGE--KPHQCFV--CGKSFTQSSILVQHQRIHTGE 1142
Cdd:COG5048    270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054 1143 KPHQCSECGKSFTHSSSL-------AQHHRIHTGEKPHQCSV--CGKSFTQSSNLAKHQRIHTGEKPHQC--SVCGKSFT 1211
Cdd:COG5048    350 SPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                          410       420       430
                   ....*....|....*....|....*....|..
gi 1117252054 1212 QSSNLAKHQRIHTGEKSHQCSECGKSFSCSST 1243
Cdd:COG5048    430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
KRAB smart00349
krueppel associated box;
314-373 2.34e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.03  E-value: 2.34e-19
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054   314 FEDVAVYFTRKEWELLEDEDKGLYRDQMLRNYQALISLGYRGPTPDLIYRIQRGQvELWV 373
Cdd:smart00349    3 FEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGE-EPWI 61
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 314-351 4.18e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.19  E-value: 4.18e-14
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1117252054  314 FEDVAVYFTRKEWELLEDEDKGLYRDQMLRNYQALISL 351
Cdd:cd07765      3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 314-352 1.43e-13

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 65.95  E-value: 1.43e-13
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1117252054  314 FEDVAVYFTRKEWELLEDEDKGLYRDQMLRNYQALISLG 352
Cdd:pfam01352    4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
546-968 4.85e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 4.85e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  546 KPHICAICGKSFTCLLTLAAHCKSHSGELPYRCTKCEHSFVCSLDLAKHQHV--HREKHQYRCVTCSKTFTYFSSLAQHR 623
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLrtHHNNPSDLNSKSLPLSNSKASSSSLS 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  624 RIHLGRKTHhctkcrkNLICWQDLSQHRCVKKADKPHHYTKCGKSFRQPSNMARHTLMQTGENNQLTCIGEKPHQCSVCG 703
Cdd:COG5048    112 SSSSNSNDN-------NLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNL 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  704 KSFTQPSHLAKHQCIHtgEKLHQFPERGKSFSCSTSLAQYQcihtgEKPYLCSDCGKSFTHPSHLAKHQLIHTGEKPHQC 783
Cdd:COG5048    185 SLLISSNVSTSIPSSS--ENSPLSSSYSIPSSSSDQNLENS-----SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  784 SVCGKSFTQSPHLTQHQRIHTGE-------KPHQCSVCGKSFTQSPHLTQHQR--IHTGE--KPHQC--SVCGKSFTQSP 850
Cdd:COG5048    258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRND 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  851 HLTQHQRIHTGEKPHQC--SVCGKSFTQSPH-----LTQHQRIHTGEKPHQCSV--CGKSFTQSPHLTQHQRIHTGEKPH 921
Cdd:COG5048    338 ALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPY 417

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 1117252054  922 QC--PVCGKSFGQSSTLAQHQRIHTGEKPHLCSVCGKSFSRSSTLARHQ 968
Cdd:COG5048    418 NCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1187-1212 2.11e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 2.11e-04
                           10        20
                   ....*....|....*....|....*.
gi 1117252054 1187 NLAKHQRIHTGEKPHQCSVCGKSFTQ 1212
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
851-876 2.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.73e-04
                           10        20
                   ....*....|....*....|....*.
gi 1117252054  851 HLTQHQRIHTGEKPHQCSVCGKSFTQ 876
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 1060-1107 2.48e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.47  E-value: 2.48e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1117252054 1060 PHQCPECGKSFSCSSTLAQHqlIHTGEKPHQCPVCGKSFSRSSTLVRH 1107
Cdd:PHA00733    73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 93-173 1.37e-27

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 107.19  E-value: 1.37e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054   93 PETWCQRFRSFHYQEAEGAQEICSHLQELCQHCLEPQHRSKEQI--LVVLEQILAILPQEMQSLQWESGAETC------A 164
Cdd:pfam02023    1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQIleLLVLEQFLTILPEEIQSWVREHHPESGeeavalA 80


                   ....*....
gi 1117252054  165 EEFQLEQAE 173
Cdd:pfam02023   81 EDLLLERGE 89
SCAN smart00431
leucine rich region;
93-198 2.36e-21

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 90.44  E-value: 2.36e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054    93 PETWCQRFRSFHYQEAEGAQEICSHLQELCQHCLEPQHRSKEQI--LVVLEQILAILPQEMQS---LQW-ESGAE--TCA 164
Cdd:smart00431    1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQIleLLVLEQFLTILPGELQAwvrEHHpESGEEavTLL 80

                            90       100       110
                    ....*....|....*....|....*....|....
gi 1117252054   165 EEFQLEqAEDNKLQVTVNVKVEEVSSDEMQPTGA 198
Cdd:smart00431   81 EDLERE-LDEPGQQVSAHVHGQEVLLEKMVPLGA 113
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 93-165 2.82e-20

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 86.55  E-value: 2.82e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1117252054   93 PETWCQRFRSFHYQEAEGAQEICSHLQELCQHCLEPQHRSKEQIL--VVLEQILAILPQEMQSLQWESGAETCAE 165
Cdd:cd07936      1 PETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILelLVLEQFLIILPPEVQAWVRERKPESGEE 75
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
891-1243 3.60e-20

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 95.53  E-value: 3.60e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  891 KPHQCSVCGKSFTQSPHLTQHQRIHTGEKPHQCPV--CGKSFGQSSTLAQHQRIHTGEKPHLCSVCGKS----------- 957
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnskassssls 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  958 ---------------------------FSRSSTLARHQLIHTG---------------EKPHHCSACGKSFTQSSHLaqH 995
Cdd:COG5048    112 ssssnsndnnllsshslppssrdpqlpDLLSISNLRNNPLPGNnsssvntpqsnslhpPLPANSLSKDPSSNLSLLI--S 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  996 QRIHTGEKPHQCSVCGKGFIHSSRLAEHQHIHTGEKPHQCSVCGKCFTQSSSLAKHQHLHTGEKPHQCPECGKSFSCSST 1075
Cdd:COG5048    190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054 1076 LAQHQLIHTGE-------KPHQCPVCGKSFSRSSTLVRHQR--IHTGE--KPHQCFV--CGKSFTQSSILVQHQRIHTGE 1142
Cdd:COG5048    270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054 1143 KPHQCSECGKSFTHSSSL-------AQHHRIHTGEKPHQCSV--CGKSFTQSSNLAKHQRIHTGEKPHQC--SVCGKSFT 1211
Cdd:COG5048    350 SPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                          410       420       430
                   ....*....|....*....|....*....|..
gi 1117252054 1212 QSSNLAKHQRIHTGEKSHQCSECGKSFSCSST 1243
Cdd:COG5048    430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
835-1266 2.15e-19

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 92.84  E-value: 2.15e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  835 KPHQCSVCGKSFTQSPHLTQHQRIHTGEKPHQCSV--CGKSFTQSPHLTQHQRIHTGEKPHQCSVCGKSFTQSPHLTQHQ 912
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  913 RIHTGEKPHQ-CPVCGKSFGQSSTLAQHQRIHTGEKPHLCSVCGKSFSRSSTLARHQLIHtgekPHHCSACGKSFTQSSH 991
Cdd:COG5048    112 SSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPL----PANSLSKDPSSNLSLL 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  992 LaqHQRIHTGEKPHQCSVCGKGFIHSSRLAEHQHIHTGEKPHQCSVCGKCFTQSSSLAKHQHLHTGEKPHQCPECGKSFS 1071
Cdd:COG5048    188 I--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054 1072 CSSTLAQHQLIHTGE-------KPHQCPVCGKSFSRSSTLVRHQR--IHTGE--KPHQCFV--CGKSFTQSSILVQHQRI 1138
Cdd:COG5048    266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054 1139 HTGEKPHQCSECGKSFTHSSSLaqhhrihtGEKPHQCSVcgksftqssnlakHQRIHTGEKPHQCSV--CGKSFTQSSNL 1216
Cdd:COG5048    346 HTSISPAKEKLLNSSSKFSPLL--------NNEPPQSLQ-------------QYKDLKNDKKSETLSnsCIRNFKRDSNL 404

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1117252054 1217 AKHQRIHTGEKSHQC--SECGKSFSCSSTLAQHQCIHTGEKPHQCSECQKSF 1266
Cdd:COG5048    405 SLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
KRAB smart00349
krueppel associated box;
314-373 2.34e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.03  E-value: 2.34e-19
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054   314 FEDVAVYFTRKEWELLEDEDKGLYRDQMLRNYQALISLGYRGPTPDLIYRIQRGQvELWV 373
Cdd:smart00349    3 FEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGE-EPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
751-1154 1.37e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 87.44  E-value: 1.37e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  751 KPYLCSDCGKSFTHPSHLAKHQLIHTGEKPHQCSV--CGKSFTQSPHLTQHQRIHTGEKPHQCSVCGKSFTQSPHLTQHQ 828
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  829 RIHTGEKPHQ-CSVCGKSFTQSPHLTQHQRIHTGEKPHQCSVCGKSFTQSPhltQHQRIHtGEKPHQCSVCGKSFTQSPH 907
Cdd:COG5048    112 SSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP---QSNSLH-PPLPANSLSKDPSSNLSLL 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  908 LtqHQRIHTGEKPHQCPVCGKSFGQSSTLAQHQRIHTGEKPHLCSVCGKSFSRSSTLARHQLIHTGEKPHHCSACGKSFT 987
Cdd:COG5048    188 I--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  988 QSSHLAQHQRIHTGE-------KPHQCSVCGKGFIHSSRLAEHQ--HIHTGE--KPHQC--SVCGKCFTQSSSLAKHQHL 1054
Cdd:COG5048    266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054 1055 HTGEKPHQCPEC-------GKSFSCSSTLAQHQLIHTGEKPHQCPV--CGKSFSRSSTLVRHQRIHTGEKPHQC--FVCG 1123
Cdd:COG5048    346 HTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCS 425

                          410       420       430
                   ....*....|....*....|....*....|.
gi 1117252054 1124 KSFTQSSILVQHQRIHTGEKPHQCSECGKSF 1154
Cdd:COG5048    426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
695-1107 1.80e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 83.98  E-value: 1.80e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  695 KPHQCSVCGKSFTQPSHLAKHQCIHTGEKLHQFPERGKSFSCSTSLAQYQC--IHTGEKPYLCSDCGKSFTH-PSHLAKH 771
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHlrTHHNNPSDLNSKSLPLSNSkASSSSLS 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  772 QLIHTGEKPHQCSVCGKSFTQSPHLTQHQRIHTGEKPHQCSVCGKSFTQSPhltQHQRIHtGEKPHQCSVCGKSFTQSPH 851
Cdd:COG5048    112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP---QSNSLH-PPLPANSLSKDPSSNLSLL 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  852 LtqHQRIHTGEKPHQCSVCGKSFTQSPHLTQHQRIHTGEKPHQCSVCGKSFTQSPHLTQHQRIHTGEKPHQCPVCGKSFG 931
Cdd:COG5048    188 I--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  932 QSSTLAQHQRIHTGE-------KPHLCSVCGKSFSRSSTLARHQ--LIHTGE--KPHHC--SACGKSFTQSSHLAQHQRI 998
Cdd:COG5048    266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  999 HTGEKPHQCSVCGKGFIHSSRLAE-------HQHIHTGEKPHQCSV--CGKCFTQSSSLAKHQHLHTGEKPHQC--PECG 1067
Cdd:COG5048    346 HTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCS 425

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1117252054 1068 KSFSCSSTLAQHQLIHTGEKPHQCPVCgKSFSRSSTLVRH 1107
Cdd:COG5048    426 KSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNH 464
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 314-351 4.18e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.19  E-value: 4.18e-14
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1117252054  314 FEDVAVYFTRKEWELLEDEDKGLYRDQMLRNYQALISL 351
Cdd:cd07765      3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 314-352 1.43e-13

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 65.95  E-value: 1.43e-13
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1117252054  314 FEDVAVYFTRKEWELLEDEDKGLYRDQMLRNYQALISLG 352
Cdd:pfam01352    4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
975-1287 1.91e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.27  E-value: 1.91e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  975 KPHHCSACGKSFTQSSHLAQHQRIHTGEKPHQCSVCGKGFIHSSRLAEHQH--IHTGEKPHQCSvcgkcftQSSSLAKHQ 1052
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHlrTHHNNPSDLNS-------KSLPLSNSK 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054 1053 HLHTGEkphqcPECGKSFSCSSTLAQHQLIHTGEKPHQCPVCGKSFSRSSTLVRHQRIHT---------GEKPHQCFVCG 1123
Cdd:COG5048    105 ASSSSL-----SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhPPLPANSLSKD 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054 1124 KSFTQSSILvqHQRIHTGEKPHQCSECGKSFTHSSSLAQHHRIHTGEKPHQCSVCGKSFTQSSNLAKHQRIHTGEKPHQC 1203
Cdd:COG5048    180 PSSNLSLLI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054 1204 SVCGKSFTQSSNLAKHQRIHTGE-------KSHQCSECGKSFSCSSTLAQHQ--CIHTGE--KPHQCSE--CQKSFTHSS 1270
Cdd:COG5048    258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337

                          330
                   ....*....|....*..
gi 1117252054 1271 SLTYHQLMHTRKKPHQC 1287
Cdd:COG5048    338 ALKRHILLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
546-968 4.85e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 4.85e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  546 KPHICAICGKSFTCLLTLAAHCKSHSGELPYRCTKCEHSFVCSLDLAKHQHV--HREKHQYRCVTCSKTFTYFSSLAQHR 623
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLrtHHNNPSDLNSKSLPLSNSKASSSSLS 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  624 RIHLGRKTHhctkcrkNLICWQDLSQHRCVKKADKPHHYTKCGKSFRQPSNMARHTLMQTGENNQLTCIGEKPHQCSVCG 703
Cdd:COG5048    112 SSSSNSNDN-------NLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNL 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  704 KSFTQPSHLAKHQCIHtgEKLHQFPERGKSFSCSTSLAQYQcihtgEKPYLCSDCGKSFTHPSHLAKHQLIHTGEKPHQC 783
Cdd:COG5048    185 SLLISSNVSTSIPSSS--ENSPLSSSYSIPSSSSDQNLENS-----SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  784 SVCGKSFTQSPHLTQHQRIHTGE-------KPHQCSVCGKSFTQSPHLTQHQR--IHTGE--KPHQC--SVCGKSFTQSP 850
Cdd:COG5048    258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRND 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054  851 HLTQHQRIHTGEKPHQC--SVCGKSFTQSPH-----LTQHQRIHTGEKPHQCSV--CGKSFTQSPHLTQHQRIHTGEKPH 921
Cdd:COG5048    338 ALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPY 417

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 1117252054  922 QC--PVCGKSFGQSSTLAQHQRIHTGEKPHLCSVCGKSFSRSSTLARHQ 968
Cdd:COG5048    418 NCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1187-1212 2.11e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 2.11e-04
                           10        20
                   ....*....|....*....|....*.
gi 1117252054 1187 NLAKHQRIHTGEKPHQCSVCGKSFTQ 1212
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
907-930 2.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.45e-04
                           10        20
                   ....*....|....*....|....
gi 1117252054  907 HLTQHQRIHTGEKPHQCPVCGKSF 930
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
851-876 2.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.73e-04
                           10        20
                   ....*....|....*....|....*.
gi 1117252054  851 HLTQHQRIHTGEKPHQCSVCGKSFTQ 876
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
879-904 2.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.73e-04
                           10        20
                   ....*....|....*....|....*.
gi 1117252054  879 HLTQHQRIHTGEKPHQCSVCGKSFTQ 904
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
795-820 2.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.73e-04
                           10        20
                   ....*....|....*....|....*.
gi 1117252054  795 HLTQHQRIHTGEKPHQCSVCGKSFTQ 820
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
823-848 2.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.73e-04
                           10        20
                   ....*....|....*....|....*.
gi 1117252054  823 HLTQHQRIHTGEKPHQCSVCGKSFTQ 848
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1132-1156 4.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 4.45e-04
                           10        20
                   ....*....|....*....|....*
gi 1117252054 1132 LVQHQRIHTGEKPHQCSECGKSFTH 1156
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1104-1128 6.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 6.34e-04
                           10        20
                   ....*....|....*....|....*
gi 1117252054 1104 LVRHQRIHTGEKPHQCFVCGKSFTQ 1128
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1215-1240 8.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 8.10e-04
                           10        20
                   ....*....|....*....|....*.
gi 1117252054 1215 NLAKHQRIHTGEKSHQCSECGKSFSC 1240
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1159-1184 8.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 8.94e-04
                           10        20
                   ....*....|....*....|....*.
gi 1117252054 1159 SLAQHHRIHTGEKPHQCSVCGKSFTQ 1184
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1076-1100 9.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 9.12e-04
                           10        20
                   ....*....|....*....|....*
gi 1117252054 1076 LAQHQLIHTGEKPHQCPVCGKSFSR 1100
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
991-1016 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 1.10e-03
                           10        20
                   ....*....|....*....|....*.
gi 1117252054  991 HLAQHQRIHTGEKPHQCSVCGKGFIH 1016
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
936-960 1.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.52e-03
                           10        20
                   ....*....|....*....|....*
gi 1117252054  936 LAQHQRIHTGEKPHLCSVCGKSFSR 960
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
767-792 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.53e-03
                           10        20
                   ....*....|....*....|....*.
gi 1117252054  767 HLAKHQLIHTGEKPHQCSVCGKSFTQ 792
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
964-988 1.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.96e-03
                           10        20
                   ....*....|....*....|....*
gi 1117252054  964 LARHQLIHTGEKPHHCSACGKSFTQ 988
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 1060-1107 2.48e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.47  E-value: 2.48e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1117252054 1060 PHQCPECGKSFSCSSTLAQHqlIHTGEKPHQCPVCGKSFSRSSTLVRH 1107
Cdd:PHA00733    73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDH 118
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1029-1107 2.95e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 2.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1117252054 1029 GEKPHQCSV--CGKCFTQSSSLAKHQ-HLHTGEKPHQCPECGKsfscsstlaqHQLIHTGEKPHQCPVCGKSFSRSSTLV 1105
Cdd:COG5189    346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                   ..
gi 1117252054 1106 RH 1107
Cdd:COG5189    416 YH 417
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1089-1111 3.00e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 3.00e-03
                           10        20
                   ....*....|....*....|...
gi 1117252054 1089 HQCPVCGKSFSRSSTLVRHQRIH 1111
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1047-1072 3.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 3.08e-03
                           10        20
                   ....*....|....*....|....*.
gi 1117252054 1047 SLAKHQHLHTGEKPHQCPECGKSFSC 1072
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1173-1195 3.51e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 3.51e-03
                           10        20
                   ....*....|....*....|...
gi 1117252054 1173 HQCSVCGKSFTQSSNLAKHQRIH 1195
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1201-1223 3.51e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 3.51e-03
                           10        20
                   ....*....|....*....|...
gi 1117252054 1201 HQCSVCGKSFTQSSNLAKHQRIH 1223
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH