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Conserved domains on  [gi|1121836276|ref|XP_019391350|]
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PREDICTED: G1/S-specific cyclin-E1 isoform X1 [Crocodylus porosus]

Protein Classification

G1/S-specific cyclin-E( domain architecture ID 15334740)

G1/S-specific cyclin-E is essential for the control of the cell cycle at the G1/S (start) transition

Gene Ontology:  GO:0000082|GO:0044772|GO:0016538|GO:0097134

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 101-237 1.59e-103

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 302.57  E-value: 1.59e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 101 SPLPVLGWGNRDEVWKNMINKEQTYVRDKLYMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQQN 180
Cdd:cd20579     1 SPLPVLGWANRDEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1121836276 181 VVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALNW 237
Cdd:cd20579    81 VVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNE1_rpt2 cd20581
second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 241-354 3.65e-80

second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410284  Cd Length: 114  Bit Score: 242.00  E-value: 3.65e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 241 PLTIVSWLNIYMQVAYLNELYEVLLPQYPQQIFVQIAELLDLCVLDIGCLEYTYGVLAASALYHFSSSELMQKVSGYEWC 320
Cdd:cd20581     1 PLTIVSWLNVYMQVAYLNELQEVLLPQYPQEIFIQIAELLDLCVLDICCLEFPYGVLAASALYHFSSSELMQKVSGYKWC 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1121836276 321 DIEECVKWMVPFAMAIREVGSSKLKHFRGIAPED 354
Cdd:cd20581    81 EIEECVKWMVPFAMAIREVGSSKLKFFKGVAIED 114
 
Name Accession Description Interval E-value
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 101-237 1.59e-103

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 302.57  E-value: 1.59e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 101 SPLPVLGWGNRDEVWKNMINKEQTYVRDKLYMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQQN 180
Cdd:cd20579     1 SPLPVLGWANRDEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1121836276 181 VVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALNW 237
Cdd:cd20579    81 VVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNE1_rpt2 cd20581
second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 241-354 3.65e-80

second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410284  Cd Length: 114  Bit Score: 242.00  E-value: 3.65e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 241 PLTIVSWLNIYMQVAYLNELYEVLLPQYPQQIFVQIAELLDLCVLDIGCLEYTYGVLAASALYHFSSSELMQKVSGYEWC 320
Cdd:cd20581     1 PLTIVSWLNVYMQVAYLNELQEVLLPQYPQEIFIQIAELLDLCVLDICCLEFPYGVLAASALYHFSSSELMQKVSGYKWC 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1121836276 321 DIEECVKWMVPFAMAIREVGSSKLKHFRGIAPED 354
Cdd:cd20581    81 EIEECVKWMVPFAMAIREVGSSKLKFFKGVAIED 114
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 113-240 1.11e-56

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 182.33  E-value: 1.11e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 113 EVWKNMINKEQTYVRDKLYMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMAtQQNVVKTLLQLIGIS 192
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLS-KKSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1121836276 193 SLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALNWNLG 240
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
118-240 2.64e-27

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 112.56  E-value: 2.64e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 118 MINKEQTYVRDKLYMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMAtQQNVVKTLLQLIGISSLFIA 197
Cdd:COG5024   188 LLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLS-SRVVSLEKYQLVGISALFIA 266

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1121836276 198 AKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALNWNLG 240
Cdd:COG5024   267 SKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNIS 309
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 148-233 6.19e-21

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 86.11  E-value: 6.19e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276  148 DWLMEVCEVYKLHRETFYLAQDFFDRFMaTQQNVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDgaCTEDEILSM 227
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFL-SDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRM 77


                   ....*.
gi 1121836276  228 ELIIMK 233
Cdd:smart00385  78 ERLLLE 83
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 243-361 1.25e-13

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 66.88  E-value: 1.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 243 TIVSWLNIYMQVAYLNELYEVL-LPQYpqqifvqiaeLLDLCVLDIGCLEYTYGVLAASALYHFSS-------SELMQKV 314
Cdd:pfam02984   2 TPLSFLRRFSKAADYLHDLELRtLAKY----------LLELTLLDYDFLKYPPSLIAAAAVYLARKtlnspewTETLEHY 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1121836276 315 SGYEWCDIEECVKWMVPFAMAIREvgSSKLKHFRGIAPEDLHNIQTH 361
Cdd:pfam02984  72 TGYSEEDLKPCVKLLLELLLNAPS--SKLQAVRRKYSSSKFMKVSTL 116
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 149-371 9.77e-03

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 37.79  E-value: 9.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 149 WLMEVCEVYKLHRETFYLAQDFFDRFMAtqQNVVKTL-LQLIGISSLFIAAKLEEiyppKLHQFayVTDGAC-------- 219
Cdd:COG5333    51 LIMDLCTRLNLPQTVLATAILFFSRFYL--KNSVEEIsLYSVVTTCVYLACKVED----TPRDI--SIESFEardlwsee 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 220 ---TEDEILSMELIIMKALNWNLgpltivswlniymqvaYLNELYEVLLPQYPQQIFVQIAELLDLC-------VLDIGC 289
Cdd:COG5333   123 pksSRERILEYEFELLEALDFDL----------------HVHHPYKYLEGFLKDLQEKDKYKLLQIAwkiindaLRTDLC 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 290 LEYTYGVLAASALYH--------------FSSSELMQKVSGYEWCDIEECvkwmvpfamairEVGSSKLKHFRGIAPEDL 355
Cdd:COG5333   187 LLYPPHIIALAALLIacevlgmpiiklldFVSYETKEEVIALNYKSIVKN------------KIKTFKAEHLSRDLPFTL 254

                         250
                  ....*....|....*.
gi 1121836276 356 HNIQTHINSLDLLDKA 371
Cdd:COG5333   255 QNIAEPQFALDKKPKS 270
 
Name Accession Description Interval E-value
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 101-237 1.59e-103

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 302.57  E-value: 1.59e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 101 SPLPVLGWGNRDEVWKNMINKEQTYVRDKLYMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQQN 180
Cdd:cd20579     1 SPLPVLGWANRDEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1121836276 181 VVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALNW 237
Cdd:cd20579    81 VVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 107-237 7.40e-90

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 267.26  E-value: 7.40e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 107 GWGNRDEVWKNMINKEQTYVRDKLYMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQQNVVKTLL 186
Cdd:cd20519     1 SWADSEEVWDLMLKKEELYKRDRDFLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKTQL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1121836276 187 QLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALNW 237
Cdd:cd20519    81 QLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 101-237 1.63e-82

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 248.99  E-value: 1.63e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 101 SPLPVLGWGNRDEVWKNMINKEQTYVRDKLYMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQQN 180
Cdd:cd20580     1 SPLPELSWGNSKDVWLNMLKKESKYVHDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1121836276 181 VVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALNW 237
Cdd:cd20580    81 INKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN_CCNE1_rpt2 cd20581
second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 241-354 3.65e-80

second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410284  Cd Length: 114  Bit Score: 242.00  E-value: 3.65e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 241 PLTIVSWLNIYMQVAYLNELYEVLLPQYPQQIFVQIAELLDLCVLDIGCLEYTYGVLAASALYHFSSSELMQKVSGYEWC 320
Cdd:cd20581     1 PLTIVSWLNVYMQVAYLNELQEVLLPQYPQEIFIQIAELLDLCVLDICCLEFPYGVLAASALYHFSSSELMQKVSGYKWC 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1121836276 321 DIEECVKWMVPFAMAIREVGSSKLKHFRGIAPED 354
Cdd:cd20581    81 EIEECVKWMVPFAMAIREVGSSKLKFFKGVAIED 114
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 113-240 1.11e-56

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 182.33  E-value: 1.11e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 113 EVWKNMINKEQTYVRDKLYMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMAtQQNVVKTLLQLIGIS 192
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLS-KKSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1121836276 193 SLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALNWNLG 240
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 112-236 5.70e-47

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 157.31  E-value: 5.70e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 112 DEVWKNMINKEQTYVRDKLYMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQQnVVKTLLQLIGI 191
Cdd:cd20507     6 KDIYKYLRQLEKKYAIDPDYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQ-VPRKKLQLVGV 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1121836276 192 SSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALN 236
Cdd:cd20507    85 TALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLD 129
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 112-236 2.38e-42

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 145.08  E-value: 2.38e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 112 DEVWKNMINKEQTYVRDKLYMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMaTQQNVVKTLLQLIGI 191
Cdd:cd20504     4 DDIYEYLRESELKHRPKPDYMRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFL-SQMSVLRSKLQLVGT 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1121836276 192 SSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALN 236
Cdd:cd20504    83 ACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLS 127
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 241-339 1.10e-39

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 137.41  E-value: 1.10e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 241 PLTIVSWLNIYMQVAYLNELY-----EVLLPQYPQQIFVQIAELLDLCVLDIGCLEYTYGVLAASALYH-FSSSELMQKV 314
Cdd:cd20520     1 PPTPNSWLNLYLQLAQLNPPPkendsAFLLPQYSLDRFVRAAQLLDLCILDIGSLQFSYSVLAASALYLvSPDDEAIEQV 80

                          90       100
                  ....*....|....*....|....*
gi 1121836276 315 SGYEWCDIEECVKWMVPFAMAIREV 339
Cdd:cd20520    81 TGYSWEQLAPCVEWMTPFAEVLEEE 105
CYCLIN_CCNE2_rpt2 cd20582
second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 241-339 2.16e-39

second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410285  Cd Length: 99  Bit Score: 136.44  E-value: 2.16e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 241 PLTIVSWLNIYMQVAYLNELYEVLLPQYPQQIFVQIAELLDLCVLDIGCLEYTYGVLAASALYHFSSSELMQKVSGYEWC 320
Cdd:cd20582     1 PVTIISWLNLYLQVDSLKDHPNVLLPQYSQETFIQIAQLLDLCILDINSLDFQYRVLAAAALCHFTSFEVVKKASGLEWD 80

                          90
                  ....*....|....*....
gi 1121836276 321 DIEECVKWMVPFAMAIREV 339
Cdd:cd20582    81 CISECVNWMVPFVRTVREC 99
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 112-237 1.40e-34

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 124.72  E-value: 1.40e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 112 DEVWKNMINKEQTYVRDKLYMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMAtqQNVVK-TLLQLIG 190
Cdd:cd20568    10 PEIFEYLRELELKTLPNPNYMDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLS--KRVVSlNKLQLVG 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1121836276 191 ISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALNW 237
Cdd:cd20568    88 ISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 131-238 1.89e-32

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 119.01  E-value: 1.89e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 131 YMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATqQNVVKTLLQLIGISSLFIAAKLEEIYPPKLHQ 210
Cdd:cd20561    25 YMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSS-MSVLRGKLQLVGTAAMLLASKFEEIYPPEVAE 103

                          90       100
                  ....*....|....*....|....*...
gi 1121836276 211 FAYVTDGACTEDEILSMELIIMKALNWN 238
Cdd:cd20561   104 FVYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 113-236 5.57e-32

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 118.13  E-value: 5.57e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 113 EVWKNMINKEQTYVRDKlYMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQqNVVKTLLQLIGIS 192
Cdd:cd20508    19 DIFDYMKEREEKFVVPD-YLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKK-VVKKEKLQLLGAT 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1121836276 193 SLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALN 236
Cdd:cd20508    97 AILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLD 140
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 131-235 1.64e-30

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 114.94  E-value: 1.64e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 131 YMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATqQNVVKTLLQLIGISSLFIAAKLEEIYPPKLHQ 210
Cdd:cd20560    57 YMRKQPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSC-MSVLRGKLQLVGTAAILLASKYEEIYPPEVDE 135

                          90       100
                  ....*....|....*....|....*
gi 1121836276 211 FAYVTDGACTEDEILSMELIIMKAL 235
Cdd:cd20560   136 FVYITDDTYTKKQLLRMEHLLLKVL 160
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 131-237 1.26e-28

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 109.36  E-value: 1.26e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 131 YMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQQnVVKTLLQLIGISSLFIAAKLEEIYPPKLHQ 210
Cdd:cd20567    42 YMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQ-VPRKELQLVGVTAMLIASKYEEIWAPEVND 120

                          90       100
                  ....*....|....*....|....*..
gi 1121836276 211 FAYVTDGACTEDEILSMELIIMKALNW 237
Cdd:cd20567   121 FVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 131-235 6.18e-28

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 107.11  E-value: 6.18e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 131 YMQK-HPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMaTQQNVVKTLLQLIGISSLFIAAKLEEIYPPKLH 209
Cdd:cd20562    29 YMEKiQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFL-SGNYVNRQRLQLLGVSCMLIASKYEEICAPQVE 107

                          90       100
                  ....*....|....*....|....*.
gi 1121836276 210 QFAYVTDGACTEDEILSMELIIMKAL 235
Cdd:cd20562   108 EFCYITDNTYTKQEVLEMEIDVLNAL 133
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
118-240 2.64e-27

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 112.56  E-value: 2.64e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 118 MINKEQTYVRDKLYMQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMAtQQNVVKTLLQLIGISSLFIA 197
Cdd:COG5024   188 LLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLS-SRVVSLEKYQLVGISALFIA 266

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1121836276 198 AKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALNWNLG 240
Cdd:COG5024   267 SKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNIS 309
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 142-235 4.20e-27

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 103.56  E-value: 4.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 142 MRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQqNVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTE 221
Cdd:cd20536     1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATT-PVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTR 79

                          90
                  ....*....|....
gi 1121836276 222 DEILSMELIIMKAL 235
Cdd:cd20536    80 EQICNLECIILTKL 93
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 110-238 1.55e-24

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 98.53  E-value: 1.55e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 110 NRDEVWKNMINKEQTYVRDKLY---MQKHplLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMAtQQNVVKTLL 186
Cdd:cd20515    22 LDDRVLQNLLSLEERYLPSASYfkcVQTE--IQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLS-LVPIRKSQL 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1121836276 187 QLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALNWN 238
Cdd:cd20515    99 QLLGAVCLFLASKLKETIPLTAEKLCIYTDNSITLQELLDWELLVLTKLKWD 150
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 142-237 5.28e-24

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 96.10  E-value: 5.28e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 142 MRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMatQQNVV-KTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACT 220
Cdd:cd20565    35 MRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFL--QNNPVpKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYT 112

                          90
                  ....*....|....*..
gi 1121836276 221 EDEILSMELIIMKALNW 237
Cdd:cd20565   113 KHQIRQMEMKILRALDF 129
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 141-237 1.66e-22

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 92.23  E-value: 1.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 141 KMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQQnVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACT 220
Cdd:cd20566    38 RMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQP-VSRKKLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYT 116

                          90
                  ....*....|....*..
gi 1121836276 221 EDEILSMELIIMKALNW 237
Cdd:cd20566   117 KAQIREMEMLILKELNF 133
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 112-238 3.06e-22

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 91.96  E-value: 3.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 112 DEVWKNMINKEQTYVRDKLY---MQKHPLlqPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQQnVVKTLLQL 188
Cdd:cd20573    23 DRVLQTMLKAEETCLPSVSYfkcVQKEIL--PSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEP-TKKSRLQL 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1121836276 189 IGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALNWN 238
Cdd:cd20573   100 LGATCMFLASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKWD 149
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 143-239 1.89e-21

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 88.15  E-value: 1.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 143 RTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMaTQQNVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTED 222
Cdd:cd20542     1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYL-SRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKK 79

                          90
                  ....*....|....*..
gi 1121836276 223 EILSMELIIMKALNWNL 239
Cdd:cd20542    80 QVLRMERRVLRRLRFDL 96
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 148-233 6.19e-21

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 86.11  E-value: 6.19e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276  148 DWLMEVCEVYKLHRETFYLAQDFFDRFMaTQQNVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDgaCTEDEILSM 227
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFL-SDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRM 77


                   ....*.
gi 1121836276  228 ELIIMK 233
Cdd:smart00385  78 ERLLLE 83
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 99-238 2.02e-20

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 86.97  E-value: 2.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276  99 RASPLPVLGWGNRdeVWKNMINKEQTYVRDKLY---MQKHplLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFM 175
Cdd:cd20574    13 RALPDPNLLYDDR--VLQNLLTIEERYLPQCSYfkcVQKD--IQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFL 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1121836276 176 ATQQnVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALNWN 238
Cdd:cd20574    89 AVVP-TRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWN 150
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 99-238 2.42e-19

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 84.27  E-value: 2.42e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276  99 RASPLPVLGWGNRdeVWKNMINKEQTYVRDKLYMQ-KHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMAT 177
Cdd:cd20575    13 RAGPDPRLLGDQR--VLQNLLRLEERYVPRVSYFQcVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSC 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1121836276 178 QQnVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALNWN 238
Cdd:cd20575    91 VP-TRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 139-237 1.64e-15

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 71.87  E-value: 1.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 139 QPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMaTQQNVVKTLLQLIGISSLFIAAKLEEIYP--PKLHQF-AYVT 215
Cdd:cd20528     3 QLHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFM-DRYDISEDQLHLVALTCLLLAAKFEELDDniPKISDLnRYLC 81

                          90       100
                  ....*....|....*....|..
gi 1121836276 216 DGACTEDEILSMELIIMKALNW 237
Cdd:cd20528    82 NSVYSKQEYLQMELLILEFFQW 103
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 149-239 7.02e-15

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 70.03  E-value: 7.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 149 WLMEVCEVYKLHRETFYLAQDFFDRFMATQQNVVKtLLQLIGISSLFIAAKLEE----IypPKLHQFAYVTDGACTEDEI 224
Cdd:cd20526     8 WLAELNSQFKFYPETFALAVSILDRFLASVKARPK-YLRCIAISCLFLAAKTNEedevI--PSTKDLVRVSKCGCSVAEV 84

                          90
                  ....*....|....*
gi 1121836276 225 LSMELIIMKALNWNL 239
Cdd:cd20526    85 LRMERIILDKLHWDL 99
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 243-361 1.25e-13

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 66.88  E-value: 1.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 243 TIVSWLNIYMQVAYLNELYEVL-LPQYpqqifvqiaeLLDLCVLDIGCLEYTYGVLAASALYHFSS-------SELMQKV 314
Cdd:pfam02984   2 TPLSFLRRFSKAADYLHDLELRtLAKY----------LLELTLLDYDFLKYPPSLIAAAAVYLARKtlnspewTETLEHY 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1121836276 315 SGYEWCDIEECVKWMVPFAMAIREvgSSKLKHFRGIAPEDLHNIQTH 361
Cdd:pfam02984  72 TGYSEEDLKPCVKLLLELLLNAPS--SKLQAVRRKYSSSKFMKVSTL 116
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 142-237 2.71e-13

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 65.28  E-value: 2.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 142 MRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQQnVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTE 221
Cdd:cd20517     5 NRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQ-GTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDCFTN 83

                          90
                  ....*....|....*.
gi 1121836276 222 DEILSMELIIMKALNW 237
Cdd:cd20517    84 LELINQEKDILEALKW 99
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 146-230 4.23e-13

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 64.35  E-value: 4.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 146 LLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQQNVVKTlLQLIGISSLFIAAKLEEIyPPKLHQFAYVTDgaCTEDEIL 225
Cdd:cd00043     2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRS-PELIAAACLYLACKLEEL-PRTLKEIAKVSG--VSEKELR 77


                  ....*
gi 1121836276 226 SMELI 230
Cdd:cd00043    78 KAEKE 82
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 143-237 1.64e-12

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 63.11  E-value: 1.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 143 RTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQ--QNVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFA-YVTDGAC 219
Cdd:cd20543     2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYdlPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQvEEPKYVF 81

                          90
                  ....*....|....*...
gi 1121836276 220 TEDEILSMELIIMKALNW 237
Cdd:cd20543    82 EAKTIQRMELLVLSTLEW 99
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 140-235 8.05e-12

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 61.18  E-value: 8.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 140 PKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQQnVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGAC 219
Cdd:cd20521     1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRK-VPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTY 79

                          90
                  ....*....|....*.
gi 1121836276 220 TEDEILSMELIIMKAL 235
Cdd:cd20521    80 KYEDVVRMMGEIVAAL 95
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 150-239 3.43e-09

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 55.29  E-value: 3.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 150 LMEVCEVYKLHRETFYLAQDFFDRFmATQQNVVKTLLQLIGISSLFIAAKLEEIYPPkLHQFAYVTDGA-CTEDEILSME 228
Cdd:cd20524    62 LLEFCRAFKLPDSVLATALTYFKRF-YLKNSVMEYHPKEIMLTCLYLACKVEEFNIS-IDQFVGNIKESeKTAEIILEYE 139

                          90
                  ....*....|.
gi 1121836276 229 LIIMKALNWNL 239
Cdd:cd20524   140 LLLLQGLNFHL 150
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 146-238 5.36e-09

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 53.16  E-value: 5.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 146 LLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQQnVVKTLLQLIGISSLFIAAKLEEIYP--PKLHQFAYVTDGACTEDE 223
Cdd:cd20559     2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRI-VLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEEL 80

                          90
                  ....*....|....*
gi 1121836276 224 ILSMELIIMKALNWN 238
Cdd:cd20559    81 FIQMEMHILNTLNWD 95
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 162-236 8.09e-06

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 44.07  E-value: 8.09e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1121836276 162 ETFYLAQDFFDRFMATQQnVVKTLLQLIGISSLFIAAKL--EEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALN 236
Cdd:cd20584    21 ETFVLAVNILDRFLALMK-VKPKHLSCIGICCFHLAARVveEECNIPSSHDLIRISQCKCTVSDLKRMEKIISEKLH 96
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 154-235 1.19e-05

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 43.50  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 154 CEVYKLHRETFYLAQDFFDRFMAtqqnVVKT---LLQLIGISSLFIAAKL--EEIYPPKLHQFAYVTDGACTEDEILSME 228
Cdd:cd20523    12 HRFYGFSPETFALAVNLLDRFLS----KVKVkpkHLACITVSCFHIAIKSveEDQNIPSAEDLIRISQCGCTAADLMRME 87


                  ....*..
gi 1121836276 229 LIIMKAL 235
Cdd:cd20523    88 GIILEKL 94
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 243-327 1.18e-04

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 40.75  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 243 TIVSWLNIYMQVAYLNELYEVLLpQYpqqifvqiaeLLDLCVLDIGCLEYTYGVLAASALY--------HFSSSELMQKV 314
Cdd:cd20537     2 TPLSFLRRYLSLLGLDEKVRHLA-RY----------LLELSLLDYEFLKYRPSLIAAAALYlarkilgePPPSPQLLQLV 70

                          90
                  ....*....|...
gi 1121836276 315 SGYEWCDIEECVK 327
Cdd:cd20537    71 TGYSENDLQECAK 83
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 150-237 5.79e-03

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 35.95  E-value: 5.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 150 LMEVCEVYKLHRETFYLAQDFFDRFMATQQnVVKTLLQLIGISSLFIAAKL--EEIYPPKLHQFAYVTDGACTEDEILSM 227
Cdd:cd20583     9 LLSLTQFFGFSTETFSLAVNLLDRFLAKMK-VQPKHLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFTVSDMMRM 87

                          90
                  ....*....|
gi 1121836276 228 ELIIMKALNW 237
Cdd:cd20583    88 EKIILEKLCW 97
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 149-371 9.77e-03

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 37.79  E-value: 9.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 149 WLMEVCEVYKLHRETFYLAQDFFDRFMAtqQNVVKTL-LQLIGISSLFIAAKLEEiyppKLHQFayVTDGAC-------- 219
Cdd:COG5333    51 LIMDLCTRLNLPQTVLATAILFFSRFYL--KNSVEEIsLYSVVTTCVYLACKVED----TPRDI--SIESFEardlwsee 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 220 ---TEDEILSMELIIMKALNWNLgpltivswlniymqvaYLNELYEVLLPQYPQQIFVQIAELLDLC-------VLDIGC 289
Cdd:COG5333   123 pksSRERILEYEFELLEALDFDL----------------HVHHPYKYLEGFLKDLQEKDKYKLLQIAwkiindaLRTDLC 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121836276 290 LEYTYGVLAASALYH--------------FSSSELMQKVSGYEWCDIEECvkwmvpfamairEVGSSKLKHFRGIAPEDL 355
Cdd:COG5333   187 LLYPPHIIALAALLIacevlgmpiiklldFVSYETKEEVIALNYKSIVKN------------KIKTFKAEHLSRDLPFTL 254

                         250
                  ....*....|....*.
gi 1121836276 356 HNIQTHINSLDLLDKA 371
Cdd:COG5333   255 QNIAEPQFALDKKPKS 270
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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