second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  206 ASELGEDLLKLYVKQCCPDIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGT 285
Cdd:cd18286      1 CSRLGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1246224499  286 LDFPDKANVGHILNMADMYGLEGLKEVAIYILRRDYCNFFQ 326
Cdd:cd18286     81 LDLPDDVNLGELLSLADMYGLDGLKDVVAYTLRRDYCHFFH 121

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental process. It may also act as a protein-protein adaptor in a transcription complex and thus may be involved in brain development.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246224499  333 LASILECLIIAHSVGVESLFADCMKWIVKHFARFWSERSFANVPPEIQKSCLNMLIQSLNDKN 395
Cdd:cd18490      2 LAGVLECLPLAHTFGLEDLYEKCLRWIAKHFAKVWSTKSFASLPPELQEKCYEALVSSLTIEN 64

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1246224499  424 SQLQEECIAFIIENFSKIIQSENFALLLQsqamsstsDLLDKILKAIEENITTEN 478
Cdd:cd18490     18 EDLYEKCLRWIAKHFAKVWSTKSFASLPP--------ELQEKCYEALVSSLTIEN 64

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  206 ASELGEDLLKLYVKQCCPDIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGT 285
Cdd:cd18286      1 CSRLGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1246224499  286 LDFPDKANVGHILNMADMYGLEGLKEVAIYILRRDYCNFFQ 326
Cdd:cd18286     81 LDLPDDVNLGELLSLADMYGLDGLKDVVAYTLRRDYCHFFH 121

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental process. It may also act as a protein-protein adaptor in a transcription complex and thus may be involved in brain development.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246224499  333 LASILECLIIAHSVGVESLFADCMKWIVKHFARFWSERSFANVPPEIQKSCLNMLIQSLNDKN 395
Cdd:cd18490      2 LAGVLECLPLAHTFGLEDLYEKCLRWIAKHFAKVWSTKSFASLPPELQEKCYEALVSSLTIEN 64

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499   224 DIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFPDKaNVGHILNMADM 303
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE-NVEELLELADY 79

                            90
                    ....*....|....*..
gi 1246224499   304 YGLEGLKEVAIYILRRD 320
Cdd:smart00225   80 LQIPGLVELCEEFLLKL 96

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1246224499   48 LLRLLREEVHTDVTFSIGCTLFKAHKAVLLARVPdfYFHT--VGHTNNLTNHEpVAVENFEASEFRIFLQIVYSS 120
Cdd:pfam00651    1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSP--YFKAlfSGQESESSVSE-ITLDDVSPEDFEALLEFMYTG 72

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental process. It may also act as a protein-protein adaptor in a transcription complex and thus may be involved in brain development.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1246224499  424 SQLQEECIAFIIENFSKIIQSENFALLLQsqamsstsDLLDKILKAIEENITTEN 478
Cdd:cd18490     18 EDLYEKCLRWIAKHFAKVWSTKSFASLPP--------ELQEKCYEALVSSLTIEN 64

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  206 ASELGEDLLKLYVKQCCPDIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGT 285
Cdd:cd18286      1 CSRLGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1246224499  286 LDFPDKANVGHILNMADMYGLEGLKEVAIYILRRDYCNFFQ 326
Cdd:cd18286     81 LDLPDDVNLGELLSLADMYGLDGLKDVVAYTLRRDYCHFFH 121

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental process. It may also act as a protein-protein adaptor in a transcription complex and thus may be involved in brain development.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246224499  333 LASILECLIIAHSVGVESLFADCMKWIVKHFARFWSERSFANVPPEIQKSCLNMLIQSLNDKN 395
Cdd:cd18490      2 LAGVLECLPLAHTFGLEDLYEKCLRWIAKHFAKVWSTKSFASLPPELQEKCYEALVSSLTIEN 64

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  224 DIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLdfPDKANVGHILNMADM 303
Cdd:pfam00651   12 DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL--ISEENVDDLLAAADK 89

                           90
                   ....*....|....
gi 1246224499  304 YGLEGLKEVAIYIL 317
Cdd:pfam00651   90 LQIPSLVDKCEEFL 103

Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1246224499 1764 DTLNRWSELTSPFDDSSASITMASFSSEDC-SPQGEWTILELETQH 1808
Cdd:pfam15363    1 DTWSRWSELSSPLDDSSASITVTSFSPEDGcSPQGEWTILELETQH 46

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  224 DIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFpDKANVGHILNMADM 303
Cdd:cd18265     25 DVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRI-QEDNVESVLEASDL 103

                           90       100
                   ....*....|....*....|..
gi 1246224499  304 YGLEGLKEVAIYIL--RRDYCN 323
Cdd:cd18265    104 LQVSKLREACVRFLegQLHPCN 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  224 DIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFpDKANVGHILNMADM 303
Cdd:cd18256     22 DVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEV-TVSNVQELLVAADM 100

                           90
                   ....*....|....*.
gi 1246224499  304 YGLEGLKEVAIYILRR 319
Cdd:cd18256    101 LQLTEVVEICCEFLKG 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  224 DIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFPDKANVGhILNMADM 303
Cdd:cd18298     14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIG-LLDLANS 92

                           90
                   ....*....|....*.
gi 1246224499  304 YGLEGLKEVAIYILRR 319
Cdd:cd18298     93 YCEERLKKLCEDIIKQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  209 LGEDLLKLYVKQCCPDIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLdf 288
Cdd:cd18280      1 LGQHFGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDEL-- 78

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1246224499  289 PDKAN-------------VGHILNMADMYGLEGLK 310
Cdd:cd18280     79 PDDVEpagsdsssldttmAQHLLAAADRYALERLR 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  213 LLKLYVKQCCPDIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFpDKA 292
Cdd:cd18238      6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTL-TVD 84

                           90
                   ....*....|....*
gi 1246224499  293 NVGHILNMADMYGLE 307
Cdd:cd18238     85 NVQSLLYAASLLQVE 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  205 PASELGEDLLKLYVKQCCPDIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGG 284
Cdd:cd18345      1 PECRLSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTG 80

                           90       100
                   ....*....|....*....|....*.
gi 1246224499  285 TLDFPDKAnVGHILNMADMYGLEGLK 310
Cdd:cd18345     81 KAPNLDKM-ADDLLAAADKYALERLK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  224 DIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFPDKaNVGHILNMADM 303
Cdd:cd18250     23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTVTQD-NVEALLRAADL 101

                   ....*...
gi 1246224499  304 YGLEGLKE 311
Cdd:cd18250    102 FQFPSVKE 109

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246224499  211 EDLLKLYVKQCCPDIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLD 287
Cdd:cd18295      8 EFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGRLE 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  209 LGEDLLKLYVKQCCPDIDIYV--DGKCFKAHRAILSARSSYFAAMLS-GCWAESSQEYITLQGIshvEMNV---LIHFIY 282
Cdd:cd18294      1 FAADMKSLINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLtGPQKESTQSPLVLSDI---EPEVfraVLEFIY 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 1246224499  283 GGTLDFpDKANVGHILNMADMYGLEGLKEV 312
Cdd:cd18294     78 TNCVTL-SNHTVIEVLAAAVEYGLDELRKL 106

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  221 CCPDIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITL--QGIShVEM-NVLIHFIYGGTLDFPDkANVGHI 297
Cdd:cd18283      1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLptAGID-VPMfSALLRYLYTGEFGSED-SRSQNL 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  205 PASELGEDLLKLYVKQCCPDIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGG 284
Cdd:cd18343      4 PECRLAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTG 83

                           90       100
                   ....*....|....*....|....*.
gi 1246224499  285 TLDFPDKAnVGHILNMADMYGLEGLK 310
Cdd:cd18343     84 KAPNLDKM-ADNLLAAADKYALERLK 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  205 PASELGEDLLKLYVKQCCPDIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGG 284
Cdd:cd18279      1 PECRLAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTG 80

                           90       100
                   ....*....|....*....|....*.
gi 1246224499  285 TLDFPDKAnVGHILNMADMYGLEGLK 310
Cdd:cd18279     81 KAPNLDKM-ADDLLAAADKYALERLK 105

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  224 DIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDF-PDKANvgHILNMAD 302
Cdd:cd18352     15 DVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDItNDIAK--DLLRAAD 92

                           90       100
                   ....*....|....*....|
gi 1246224499  303 MYGLEGLKEVAIYILRRDYC 322
Cdd:cd18352     93 QYLLEGLKRLCEYTIAQDLT 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  224 DIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGG--TLDFpdkANVGHILNMA 301
Cdd:cd18255     20 DVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSelTLDL---DCIQDVLGAA 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  224 DIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFpDKANVGHILNMADM 303
Cdd:cd18249     25 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTSQITV-EEGNVQTLLPAACL 103

                           90
                   ....*....|....*.
gi 1246224499  304 YGLEGLKEVAIYILRR 319
Cdd:cd18249    104 LQLAEIQEVCCEFLKR 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  224 DIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFPDKaNVGHILNMADM 303
Cdd:cd18272     34 DVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVE-ELQETYEVADM 112

                   ....*...
gi 1246224499  304 YGLEGLKE 311
Cdd:cd18272    113 YQLTALFE 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  224 DIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITlqgISHVEMNV---LIHFIYGGTLDFPDKAN--VGHIL 298
Cdd:cd18297     14 DVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIE---IPDIRYDIfqlMMQYLYTGGVESLDVAQddALELL 90

                           90
                   ....*....|...
gi 1246224499  299 NMADMYGLEGLKE 311
Cdd:cd18297     91 RAASFFQLDGLKR 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1246224499  224 DIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFpDKANVGHILNMA 301
Cdd:cd18251     25 DVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELEL-SLDNVQETLTAA 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  209 LGEDLLKLYVKQCCPDIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDF 288
Cdd:cd18353      7 VAESLKKEFDSPETSDLKFRVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQFSYPVYRAFLEYLYTDSVDL 86

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1246224499  289 PDKANVGhILNMADMYGLEGLKEVAIYILRR 319
Cdd:cd18353     87 PPEDAIG-LLDLATSYCENRLKKLCQHIIKR 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246224499  204 EPASELGEDLLKLYVKQCCPDIDIYVDGKCFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYG 283
Cdd:cd18270      8 EYAVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYT 87