NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1270003692|ref|XP_022748494.1|]
View 

uncharacterized protein LOC111298057 [Durio zibethinus]

Protein Classification

LYR motif-containing protein( domain architecture ID 10591138)

LYR motif-containing protein plays a key role in the assembly and function of complexes I, II, and III; LYR motifs are molecular signatures of specific recipient Fe-S proteins or accessory factors that assist Fe-S cluster delivery

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Complex1_LYR_2 pfam13233
Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, ...
 11-104 1.06e-06

Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, pfam05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.


:

Pssm-ID: 463812  Cd Length: 79  Bit Score: 43.10  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270003692  11 KVYRDLLKAVKKHIgnEEYKRHFSEYITQEFRKSCQLSDPslvtqkiklaNDYIFLLNSVHHHKDLLFSYNiavdRSDEM 90
Cdd:pfam13233   3 SLYRALLRELRELP--PNGRSYGRQYLRAEFRRHKHLTDP----------EEIAEFLKSWREYKELLERYN----PMTEE 66

                          90
                  ....*....|....
gi 1270003692  91 KRtLGKSAASVGLQ 104
Cdd:pfam13233  67 ER-VRLTARRVGLQ 79
 
Name Accession Description Interval E-value
Complex1_LYR_2 pfam13233
Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, ...
 11-104 1.06e-06

Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, pfam05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.


Pssm-ID: 463812  Cd Length: 79  Bit Score: 43.10  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270003692  11 KVYRDLLKAVKKHIgnEEYKRHFSEYITQEFRKSCQLSDPslvtqkiklaNDYIFLLNSVHHHKDLLFSYNiavdRSDEM 90
Cdd:pfam13233   3 SLYRALLRELRELP--PNGRSYGRQYLRAEFRRHKHLTDP----------EEIAEFLKSWREYKELLERYN----PMTEE 66

                          90
                  ....*....|....
gi 1270003692  91 KRtLGKSAASVGLQ 104
Cdd:pfam13233  67 ER-VRLTARRVGLQ 79
Complex1_LYR_SF cd20251
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ...
 11-64 2.92e-03

LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism.


Pssm-ID: 380755  Cd Length: 57  Bit Score: 33.29  E-value: 2.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1270003692  11 KVYRDLLKAVKKHiGNEEYKRHFSEYITQEFRKSCQLSDPSLVTQKIKLANDYI 64
Cdd:cd20251     3 KLYRDLLRLARKG-LPSRKRDALRQRIREEFRKNKNETDPEKIEELLAEARRGL 55
 
Name Accession Description Interval E-value
Complex1_LYR_2 pfam13233
Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, ...
 11-104 1.06e-06

Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, pfam05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.


Pssm-ID: 463812  Cd Length: 79  Bit Score: 43.10  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270003692  11 KVYRDLLKAVKKHIgnEEYKRHFSEYITQEFRKSCQLSDPslvtqkiklaNDYIFLLNSVHHHKDLLFSYNiavdRSDEM 90
Cdd:pfam13233   3 SLYRALLRELRELP--PNGRSYGRQYLRAEFRRHKHLTDP----------EEIAEFLKSWREYKELLERYN----PMTEE 66

                          90
                  ....*....|....
gi 1270003692  91 KRtLGKSAASVGLQ 104
Cdd:pfam13233  67 ER-VRLTARRVGLQ 79
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 4-63 2.19e-05

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 39.10  E-value: 2.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270003692   4 QQALaaaKVYRDLLKAVKKhIGNEEYKRHFSEYITQEFRKSCQLSDPSLVTQKIKLANDY 63
Cdd:pfam05347   1 RQVL---SLYRALLRAARK-FPDYNFREYFRRRIRDEFRKNKDLTDPEKIEKLLKEGKEE 56
Complex1_LYR_SF cd20251
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ...
 11-64 2.92e-03

LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism.


Pssm-ID: 380755  Cd Length: 57  Bit Score: 33.29  E-value: 2.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1270003692  11 KVYRDLLKAVKKHiGNEEYKRHFSEYITQEFRKSCQLSDPSLVTQKIKLANDYI 64
Cdd:cd20251     3 KLYRDLLRLARKG-LPSRKRDALRQRIREEFRKNKNETDPEKIEELLAEARRGL 55
Complex1_LYR_LYRM1 cd20261
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and ...
 13-67 8.74e-03

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins; LYR motif-containing protein 1 (LYRM1) may promote cell proliferation and inhibition of apoptosis of preadipocytes. Overexpression of the human LYRM1 causes mitochondrial dysfunction and induces insulin resistance in 3T3-L1 adipocytes. LYRM1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380756  Cd Length: 70  Bit Score: 32.60  E-value: 8.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1270003692  13 YRDLLKAVKKHIGNEEYKRhfsEYITQE----FRKSCQLSDPSLVTQKIKLANDYIFLL 67
Cdd:cd20261     6 YRRILRLARTWPADTEEER---EYILNEarslFRKNKNLTDPEEIEEKIQEAESRLELA 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH