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Conserved domains on  [gi|1370507451|ref|XP_024302110|]
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pre T-cell antigen receptor alpha isoform X1 [Homo sapiens]

Protein Classification

PTCRA domain-containing protein( domain architecture ID 10633255)

PTCRA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTCRA pfam15028
Pre-T-cell antigen receptor; The pre-T-cell antigen receptor (pre-TCR), expressed by immature ...
 1-113 1.57e-63

Pre-T-cell antigen receptor; The pre-T-cell antigen receptor (pre-TCR), expressed by immature thymocytes, has a pivotal role in early T-cell development, including TCR beta-selection, survival and proliferation of CD4(-)CD8(-) double-negative thymocytes, and subsequent alpha/beta T-cell lineage differentiation. This protein contains an immunoglobulin domain.


:

Pssm-ID: 464455  Cd Length: 127  Bit Score: 194.31  E-value: 1.57e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370507451   1 MLLVDGKQQMVVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSPATDGTWTNLAHLSLPSEELASWEPLVCHTGPGA 80
Cdd:pfam15028  15 TLLVDGKQQTLVVCLVLDVAPPGFDSPIWFSAGNGSALDAFTYGPSPATDGTWTSLAQLSLPSEELAAWEPLVCHTGPGA 94

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1370507451  81 EGHSRSTQPMHLSGEASTARTCPQEPLRGTPGG 113
Cdd:pfam15028  95 GGHGRSTQPLQLSGEASTARTCPQEPLAGTQAQ 127
 
Name Accession Description Interval E-value
PTCRA pfam15028
Pre-T-cell antigen receptor; The pre-T-cell antigen receptor (pre-TCR), expressed by immature ...
 1-113 1.57e-63

Pre-T-cell antigen receptor; The pre-T-cell antigen receptor (pre-TCR), expressed by immature thymocytes, has a pivotal role in early T-cell development, including TCR beta-selection, survival and proliferation of CD4(-)CD8(-) double-negative thymocytes, and subsequent alpha/beta T-cell lineage differentiation. This protein contains an immunoglobulin domain.


Pssm-ID: 464455  Cd Length: 127  Bit Score: 194.31  E-value: 1.57e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370507451   1 MLLVDGKQQMVVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSPATDGTWTNLAHLSLPSEELASWEPLVCHTGPGA 80
Cdd:pfam15028  15 TLLVDGKQQTLVVCLVLDVAPPGFDSPIWFSAGNGSALDAFTYGPSPATDGTWTSLAQLSLPSEELAAWEPLVCHTGPGA 94

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1370507451  81 EGHSRSTQPMHLSGEASTARTCPQEPLRGTPGG 113
Cdd:pfam15028  95 GGHGRSTQPLQLSGEASTARTCPQEPLAGTQAQ 127
 
Name Accession Description Interval E-value
PTCRA pfam15028
Pre-T-cell antigen receptor; The pre-T-cell antigen receptor (pre-TCR), expressed by immature ...
 1-113 1.57e-63

Pre-T-cell antigen receptor; The pre-T-cell antigen receptor (pre-TCR), expressed by immature thymocytes, has a pivotal role in early T-cell development, including TCR beta-selection, survival and proliferation of CD4(-)CD8(-) double-negative thymocytes, and subsequent alpha/beta T-cell lineage differentiation. This protein contains an immunoglobulin domain.


Pssm-ID: 464455  Cd Length: 127  Bit Score: 194.31  E-value: 1.57e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370507451   1 MLLVDGKQQMVVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSPATDGTWTNLAHLSLPSEELASWEPLVCHTGPGA 80
Cdd:pfam15028  15 TLLVDGKQQTLVVCLVLDVAPPGFDSPIWFSAGNGSALDAFTYGPSPATDGTWTSLAQLSLPSEELAAWEPLVCHTGPGA 94

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1370507451  81 EGHSRSTQPMHLSGEASTARTCPQEPLRGTPGG 113
Cdd:pfam15028  95 GGHGRSTQPLQLSGEASTARTCPQEPLAGTQAQ 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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