BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782  13 FENALQNEDRYDIIIKAGEdpdvKELRANSFVLCARCSYFKRALSNEWEEIDDDGNYIfkkPNISFEVFQLILRYLYTGT 92
Cdd:pfam00651   1 LNELREQGELCDVTLVVGD----KEFRAHKAVLAACSPYFKALFSGQESESSVSEITL---DDVSPEDFEALLEFMYTGK 73

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2749809782  93 IDynqyNKDVILQCLVASDELGLDKLIEHIQEYLVKNE 130
Cdd:pfam00651  74 LI----SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782  13 FENALQNEDRYDIIIKAGEdpdvKELRANSFVLCARCSYFKRALSNEWEEIDDDGNYIfkkPNISFEVFQLILRYLYTGT 92
Cdd:pfam00651   1 LNELREQGELCDVTLVVGD----KEFRAHKAVLAACSPYFKALFSGQESESSVSEITL---DDVSPEDFEALLEFMYTGK 73

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2749809782  93 IDynqyNKDVILQCLVASDELGLDKLIEHIQEYLVKNE 130
Cdd:pfam00651  74 LI----SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782   24 DIIIKAGEdpdvKELRANSFVLCARCSYFKRALSNEWEEiDDDGNYIFkkPNISFEVFQLILRYLYTGTIDYNQYNKDVI 103
Cdd:smart00225   1 DVTLVVGG----KKFHAHKAVLAAHSPYFKALFSSDFKE-SDKSEIYL--DDVSPEDFRALLNFLYTGKLDLPEENVEEL 73

                           90       100
                   ....*....|....*....|....*..
gi 2749809782  104 LQclvASDELGLDKLIEHIQEYLVKNE 130
Cdd:smart00225  74 LE---LADYLQIPGLVELCEEFLLKLL 97

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782  152 SLKDYCLEIISEEPKILFSSQNFSSLEKPIITMVLQRDDLNM-EEIDIWESILRWLfvhylkvgkddstwsSEDLTSVKQ 230
Cdd:smart00875  15 ELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVsSEEEVFEAVLRWV---------------KHDPEKRRE 79

                           90
                   ....*....|....*....
gi 2749809782  231 TIKEYIPFIRFYDISKEDF 249
Cdd:smart00875  80 HLPELLEHVRLPLLSPDYL 98

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782  13 FENALQNEDRYDIIIKAGEdpdvKELRANSFVLCARCSYFKRALSNEWEEIDDDGNYIfkkPNISFEVFQLILRYLYTGT 92
Cdd:pfam00651   1 LNELREQGELCDVTLVVGD----KEFRAHKAVLAACSPYFKALFSGQESESSVSEITL---DDVSPEDFEALLEFMYTGK 73

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2749809782  93 IDynqyNKDVILQCLVASDELGLDKLIEHIQEYLVKNE 130
Cdd:pfam00651  74 LI----SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782   24 DIIIKAGEdpdvKELRANSFVLCARCSYFKRALSNEWEEiDDDGNYIFkkPNISFEVFQLILRYLYTGTIDYNQYNKDVI 103
Cdd:smart00225   1 DVTLVVGG----KKFHAHKAVLAAHSPYFKALFSSDFKE-SDKSEIYL--DDVSPEDFRALLNFLYTGKLDLPEENVEEL 73

                           90       100
                   ....*....|....*....|....*..
gi 2749809782  104 LQclvASDELGLDKLIEHIQEYLVKNE 130
Cdd:smart00225  74 LE---LADYLQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782   7 SEVIQDFENALQNEDRYDIIIKAGEdpdvKELRANSFVLCARCSYFkRAL-------SNEWE-EIDDdgnyifkkpnISF 78
Cdd:cd18287     7 HFLSEDIGALFLNEEYSDVTFVVEE----KRFPAHRVILAARSEYF-RALlyggmreSQQSEiELKD----------TNA 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2749809782  79 EVFQLILRYLYTGTIDYNQYNKDVILQCLVASDELGLDKLIEHIQEYL 126
Cdd:cd18287    72 EAFKALLKYIYTGRLTLTDLKEDVLLDVLGLAHQYGFEELEAAISDYL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782  24 DIIIKAGEdpdvKELRANSFVLCARCSYFKRALSNEWEEIDDdgnYIFKKPNISFEVFQLILRYLYTGTIDYNQYNkdvI 103
Cdd:cd18240    19 DVVIRVNG----VEFPAHRNILCACSPYFRALFTNGWNETEK---KVYKIPGVSPEMMELIIEYAYTRTVPITAEN---V 88

                          90       100
                  ....*....|....*....|....*.
gi 2749809782 104 LQCLVASDELGLDKLIEHIQEYLVKN 129
Cdd:cd18240    89 EELLPAADQFNIMGIVKACCDFLEDQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782  40 ANSFVLCARCSYFKRALSNEWEEIDDDGNYIfkkPNISFEVFQLILRYLYTGTIDYNQYNKDVILQCLVASDELGLDKLI 119
Cdd:cd18297    26 AHKIVLVTASDRFKSMLSSGSTEAQTPVIEI---PDIRYDIFQLMMQYLYTGGVESLDVAQDDALELLRAASFFQLDGLK 102

                  ..
gi 2749809782 120 EH 121
Cdd:cd18297   103 RH 104

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782 326 LLLRGTRDGFDPDMFHQLCDEKGATISIarIKDSK-QIVGGYNPLSWN-SNGSYMNTSESFLFYITDvgnlssaKIgRVF 403
Cdd:pfam07534   1 LLYSTSRDGSSYQTFLEKIDNKGPTLLI--IKDNDgYIFGAFASQPWKvSGKKFYGDGESFLFSLSP-------QF-DPY 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2749809782 404 RYHQ--NAIYGDSGYGPTFGNG---HDLY--AQNKSWSASNGNAYTN----INIPSSFTIDEYEVFQV 460
Cdd:pfam07534  71 KWTGknNAYFNCTSDGLGFGGGqpkFDLWidSDLEFGYSRHCETFGNgqlsGSGQERFKIDDVEVWGL 138

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782  20 EDRYDIIIKAgedPDVKELRANSFVLCARCSYFKRALSNEWEEIDDDGNYIFKkpnISFEVFQLILRYLYTGTIDY--NQ 97
Cdd:cd18302     3 SDLYDVTIVS---EDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMP---IPSDILEIILDYLYTDEASAvkES 76

                          90       100
                  ....*....|....*....|...
gi 2749809782  98 YNKDVILQCLVASDELGLDKLIE 120
Cdd:cd18302    77 QNVEFLCNVLVIADQLLITRLKE 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782  36 KELRANSFVLCARCSYFkRALSNEWEEIDDDGNYIFKKPNISFEVFQLILRYLYTGTIDYNQYNKDVILQclvASDELGL 115
Cdd:cd18245    24 EEIPVQKNVLAAASPYF-RAKLNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQ---AADLLLM 99

                          90
                  ....*....|.
gi 2749809782 116 DKLIEHIQEYL 126
Cdd:cd18245   100 TDLKDLCCEFL 110

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782  10 IQDFENALQNEDRYD----IIIKAGEdpdvKELRANSFVLCARCSYFKRALSNEWEEIDD-DGNYIFKKPNISFEVFQLI 84
Cdd:cd18301     2 QEDFKKLLDEADEGDnihdVVFQVGG----KTFPAHKFILASRSDYFRKLFLSSLLTSEDaVGCDVVHIEKVPPEIFEQL 77

                          90
                  ....*....|
gi 2749809782  85 LRYLYTGTID 94
Cdd:cd18301    78 LQFIYTDTCD 87

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782  40 ANSFVLCARCSYFKRALSNEWEEiddDGNYIFKKPNISFEVFQLILRYLYTGTIDYNQYNKDVILqcLVASDELGLDKLI 119
Cdd:cd18300    23 AHKALLVARCDVMAAMFGGNFRE---SSAKEVELPGVSKETFLALLEYLYTDQAPILEDGDCVGL--IVLANRLCLPRLV 97

                          90
                  ....*....|
gi 2749809782 120 EHIQEYLVKN 129
Cdd:cd18300    98 ALCEQYIVKE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782  17 LQNEDRY-DIIIKAGEdpdvKELRANSFVLCARCSYFKRALSNEWEEIDDDGnyifkkpnISFEVFQLILRYLYTGTIDY 95
Cdd:cd18303    12 LFDKELYsDITIKLAD----KSIPAHKFVLAARSEKWSNENLASTNELDLSD--------ISYEVVLALLRWLYTDELDL 79

                          90       100
                  ....*....|....*....|....*
gi 2749809782  96 NQyNKDVILQCLVASDELGLDKLIE 120
Cdd:cd18303    80 TL-DDEFLLELMKAAKRFQLTDLVE 103

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2749809782 153 LKDYCLEIISEEPKILFSSQNFSSLEKPIITMVLQRDDLNMEEIDIWESILRW 205
Cdd:cd18488    21 LMQRCWEVIDAQAELALKSEGFTEIDYKTLESILRRETLNAKESVVFEAALRW 73

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2749809782 151 ASLKDYCLEIISEEPKILFSSQNFSSLEKPIITMVLQRDDLNM-EEIDIWESILRWL 206
Cdd:cd18480    19 TRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVpDEEAVLKAVLRWT 75

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782  11 QDFENALQNEDRY----DIIIKAGedpdvKELRANSFVLCARCSYFKRALSNEWEEIDD-----DGNYIFKKPNISFEVF 81
Cdd:cd18310     5 SDLENLLDSPDLFysdaEIIVEGG-----RPVPVHRCILAARSPFFRDIFASAKAEGANtkpklELRELIPGGIVGYDAF 79

                          90
                  ....*....|
gi 2749809782  82 QLILRYLYTG 91
Cdd:cd18310    80 MLVLSYLYSG 89

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2749809782 153 LKDYCLEIISEEPKILFSSQNFSSLEKPIITMVLQRDDLNMEEIDIWESILRW 205
Cdd:cd18494    20 LKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREW 72

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782   5 YWSEVIQDFENALQNEDRY-DIIIKAGEdpdvKELRANSFVLCARCSYFK-RALSNEWEEidddgnyifKKPNISFE--- 79
Cdd:cd18269     9 YQQTLLQDGLKDLLDENKFvDCVLKIGD----KEFPCHRLVLAACSPYFRaMFLSDLEES---------KKKEVVLEdvd 75

                          90       100
                  ....*....|....*....|..
gi 2749809782  80 --VFQLILRYLYTGTIDYNQYN 99
Cdd:cd18269    76 pdVMGMILKYLYTSEIDLNDQN 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782  36 KELRANSFVLCARCSYFKRALSNEWEEIDDDGNYIfkkPNISFEVFQLILRYLYTGTIDYNQYNKDVIlqcLVASDELGL 115
Cdd:cd18343    31 QEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEI---NDVDPEVFKEMMRFIYTGKAPNLDKMADNL---LAAADKYAL 104

                          90
                  ....*....|....
gi 2749809782 116 DKLIEHIQEYLVKN 129
Cdd:cd18343   105 ERLKVMCEEALCNN 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782   5 YWSEVIQDFENALQNEDRY-DIIIKAGEdpdvKELRANSFVLCARCSYFKRA-LSNEWEEIDDDGNYIFKKPNIsfevFQ 82
Cdd:cd18341     9 YQSTLLQDGLKELLDENKFvDCTLKAGD----KSLPCHRLILAACSPYFREYfLSEESEEKKKEVVLDNVDPNI----MD 80

                          90
                  ....*....|....*..
gi 2749809782  83 LILRYLYTGTIDYNQYN 99
Cdd:cd18341    81 MILKYLYSAEIDLNDGN 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782  34 DVKELRANSFVLCARCSYFKRALSNEWEEIDDDgnyIFKKPNISFEVFQLILRYLYTGTIDYNQYNKDVILQCLVASDEL 113
Cdd:cd18353    28 DGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKE---VIEIDQFSYPVYRAFLEYLYTDSVDLPPEDAIGLLDLATSYCEN 104

                  ....*....
gi 2749809782 114 GLDKLIEHI 122
Cdd:cd18353   105 RLKKLCQHI 113

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749809782  10 IQDFENALQNEDRYDIIIKAgedPDVKELRANSFVLCARCSYFkrALSNEWEEIDDDGNYIfkkPN-ISFEVFQLILRYL 88
Cdd:cd18311     2 LQRLQNLFNKTEYCDLTLQF---RDNEQLKVHRLVLSACTDYF--NVLEQTCEIVDDTLIM---PNeLQADAVVPVINFM 73

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2749809782  89 YTGTIDYNQynkDVILQCLVASDELGLDKLIE 120
Cdd:cd18311    74 YTGQLEFEE---KSYGKLLRTAKELNMTVLLK 102