|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
1-416 |
0e+00 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 619.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 1 MIVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGL 80
Cdd:cd17424 3 MIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLASTGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 81 ILSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLI 160
Cdd:cd17424 83 ILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 161 LGGFVLNLCVCGALMRpialkedrktapefleqdyvpdaqkqdlkqmsncsplikawsreclcycswkeydFLLMPGFMV 240
Cdd:cd17424 163 LGGFVLNLCVCGALMR-------------------------------------------------------FLLMPDFLV 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 241 LAVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYRHFCYLFAVGMDGLCCL 320
Cdd:cd17424 188 LAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 321 FLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLL 400
Cdd:cd17424 268 FLPILKTFPLLVPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLL 347
|
410
....*....|....*.
gi 1443618767 401 CGFSMIFSSTLLCFAR 416
Cdd:cd17424 348 SGFSMIFSSLLLGSAR 363
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
1-416 |
2.81e-111 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 332.98 E-value: 2.81e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 1 MIVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGL 80
Cdd:cd17352 3 VVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 81 ILSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLI 160
Cdd:cd17352 83 LLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 161 LGGFVLNLCVCGALMRpialkedrktapefleqdyvpdaqkqdlkqmsncsplikawsreclcycswkeydFLLMPGFMV 240
Cdd:cd17352 163 LGGLCLNLCVCGLLLR-------------------------------------------------------LLKDPTFVL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 241 LAVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYRhfCYLFAVGMDGLCCL 320
Cdd:cd17352 188 LALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLY--LYIFTLLILGLSLL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 321 FLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLL 400
Cdd:cd17352 266 AFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYF 345
|
410
....*....|....*.
gi 1443618767 401 CGFSMIFSSTLLCFAR 416
Cdd:cd17352 346 CGACLLLSGVLLFLLP 361
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
2-437 |
2.67e-90 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 282.40 E-value: 2.67e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 2 IVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLI 81
Cdd:TIGR00892 20 VLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGLLASLGMI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 82 LSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLIL 161
Cdd:TIGR00892 100 LASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFGWRGSFLIL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 162 GGFVLNLCVCGALMRPIALKedrktapefleqdyvPDAQKQDLKQMSNCSPLIKAWSRECLCYCSWKEYDFLLMP--GFM 239
Cdd:TIGR00892 180 GGLLLHCCVCGALMRPVGPS---------------QRVSKSKSKEGLPPDGSTKKLSKKSTAEKINRFLDFSLFThrGFL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 240 VLAVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYRHFCYLFAVGMDGLCC 319
Cdd:TIGR00892 245 VYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNGLTH 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 320 LFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFL 399
Cdd:TIGR00892 325 LLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFY 404
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1443618767 400 LCGFSMIFSSTLL--CFARVAKKIKKTRLQSLANDASTKQ 437
Cdd:TIGR00892 405 ASGSIVVSAGLFLaiGNYINYRLLAKEQKAALEREGARDK 444
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
1-412 |
8.94e-88 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 273.50 E-value: 8.94e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 1 MIVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGL 80
Cdd:cd17423 3 VVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSLGF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 81 ILSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLI 160
Cdd:cd17423 83 LLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 161 LGGFVLNLCVCGALMRPIALKEDrktapefleqdyvpdaqkqdlkqmsncspLIKAWSRECLCYcswkEYDFLLMPGFMV 240
Cdd:cd17423 163 LSALSLHLVPCGALLRPLALPGD-----------------------------PPAPPRSLSAAF----GLSLLTHRAFLR 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 241 LAVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYrHFCYLFAvGMDGLCCL 320
Cdd:cd17423 210 YALATTLINTGYFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRLL-HLLVLWT-ALTGLSLL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 321 FLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLL 400
Cdd:cd17423 288 LLPLAKVYGSLLALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLV 367
|
410
....*....|...
gi 1443618767 401 CG-FSMIFSSTLL 412
Cdd:cd17423 368 AGsFLLLGSLILL 380
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
2-415 |
1.26e-69 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 225.76 E-value: 1.26e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 2 IVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLI 81
Cdd:cd17430 4 VLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASLGMI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 82 LSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLIL 161
Cdd:cd17430 84 LASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGFLIL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 162 GGFVLNLCVCGALMRPIalkedrktapefleqdyvpdaqkqDLKQMSNcsplikawsreclcycswkeydfllmPGFMVL 241
Cdd:cd17430 164 GGLLLNCCTCGAVMRPL------------------------DFSVFRD--------------------------RGFVIY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 242 AVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYRHFCYLFAVGMDGLCCLF 321
Cdd:cd17430 194 TIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPRVVYLFSFAMLFNGLTDLC 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 322 LPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLLC 401
Cdd:cd17430 274 SATAADYGGLVVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLA 353
|
410
....*....|....
gi 1443618767 402 GFSMIFSSTLLCFA 415
Cdd:cd17430 354 GSEVVLSALFLALG 367
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
2-416 |
1.69e-66 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 217.69 E-value: 1.69e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 2 IVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLI 81
Cdd:cd17422 4 VAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLGMI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 82 LSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLIL 161
Cdd:cd17422 84 TASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLLVV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 162 GGFVLNLCVCGALMRpiALKEdrktapefleqdyvpdaqkqdlkqmsncsplikawsreclcycswkeydfllmPGFMVL 241
Cdd:cd17422 164 GALQLNIVVCGALLR--VLKE-----------------------------------------------------PGFICY 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 242 AVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYrhFCYLFAVGMDGLCCLF 321
Cdd:cd17422 189 ALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRKI--YIELICVILLCVVLLL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 322 LPVLQSFPLLVPFSFTFGYFDGAYV-TLIP-VVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFL 399
Cdd:cd17422 267 FPFAYGFWSLLVCSIFYGFMFGTVAgTHIPlLAEDDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFY 346
|
410
....*....|....*..
gi 1443618767 400 LCGFSMIFSSTLLCFAR 416
Cdd:cd17422 347 SCAAGMALGAVFLALVR 363
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
2-412 |
7.78e-64 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 210.82 E-value: 7.78e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 2 IVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLI 81
Cdd:cd17427 4 VVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSLGMI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 82 LSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLIL 161
Cdd:cd17427 84 SASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSFLIL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 162 GGFVLNLCVCGALMRPIAlkedrktapefleqdyvpdaqkqdlkqmsncsPLIKawsreclcycswkeydfllMPGFMVL 241
Cdd:cd17427 164 GGLLLNCCVAGSLMRPLG--------------------------------PLFK-------------------HRGFLIY 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 242 AVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYRHFCYLFAVGMDGLCCLF 321
Cdd:cd17427 193 LSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 322 LPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLLC 401
Cdd:cd17427 273 CPLAEDYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVC 352
|
410
....*....|.
gi 1443618767 402 GFSMIFSSTLL 412
Cdd:cd17427 353 GAIVIVASIWL 363
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
1-420 |
1.04e-62 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 208.14 E-value: 1.04e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 1 MIVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGL 80
Cdd:cd17421 3 MIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSAGF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 81 ILSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVGKYFNRRKALAYGIAMSGSGIgTFILAPVVQLLIEQFSWRGALLI 160
Cdd:cd17421 83 LISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGL-TFALAPFTQLLLDEYDWQGALLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 161 LGGFVLNLCVCGALMRPIalkedrktapefleqdyvpdaqkqdlkqmsncsplikawsreclcycswkEYDFLLMPGFMV 240
Cdd:cd17421 162 FGGIMLNLVASGMLLRPI--------------------------------------------------DFSLLKDPFFCI 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 241 LAVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYR-HFCYLFAVGMDGLCC 319
Cdd:cd17421 192 YTWSFVFSQLAYFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWIKKYHyHKAYLILCGVTNLLA 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 320 lflPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFL 399
Cdd:cd17421 272 ---PLATTYPLLMTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFY 348
|
410 420
....*....|....*....|.
gi 1443618767 400 LCGFSMIFSSTLLCFARVAKK 420
Cdd:cd17421 349 LAGGCYLLSSVSFFLEPLARR 369
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
1-415 |
4.54e-61 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 203.46 E-value: 4.54e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 1 MIVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGL 80
Cdd:cd17425 3 VVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGVGM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 81 ILSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLI 160
Cdd:cd17425 83 VASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSFLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 161 LGGFVLNLCVCGALMRPialkedrktapefleqdyvpdaqkqdlkqmsncsplikawsreclcYCSWKeydfllmpGFMV 240
Cdd:cd17425 163 FGGVLLNCCVCGAVMRP----------------------------------------------FCSNT--------RYQI 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 241 LAVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYRHFCYLFAVGMDGLCCL 320
Cdd:cd17425 189 YTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 321 FLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLL 400
Cdd:cd17425 269 ICAISASFPVLLVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYA 348
|
410
....*....|....*
gi 1443618767 401 CGFSMIFSSTLLCFA 415
Cdd:cd17425 349 SSIFVVSAALFMGLS 363
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
2-412 |
9.93e-55 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 187.01 E-value: 9.93e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 2 IVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLI 81
Cdd:cd17426 4 VVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGAGLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 82 LSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLIL 161
Cdd:cd17426 84 AASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSFLIL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 162 GGFVLNLCVCGALMRPIALKedrktapefleqdyvpdaqkqdlkqmsncsPLIkawsreclcycswkEYDFLLMPGFMVL 241
Cdd:cd17426 164 GGLLLNCCVAGSLMRPIGPK------------------------------PFL--------------DLTLFTHRGFLLY 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 242 AVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYRHFCYLFAVGMDGLCCLF 321
Cdd:cd17426 200 LSGNVIMFFGLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGVCHLL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 322 LPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLLC 401
Cdd:cd17426 280 APLSTSYVGFCIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWAC 359
|
410
....*....|.
gi 1443618767 402 GFSMIFSSTLL 412
Cdd:cd17426 360 GIVLIISSIYL 370
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
1-403 |
1.98e-50 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 175.40 E-value: 1.98e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 1 MIVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGL 80
Cdd:cd17429 3 MVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSLGW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 81 ILSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLI 160
Cdd:cd17429 83 VLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAMFI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 161 LGGFVLNLCVCGALMRpialkedrktapEFLEQDYVPdaqkqdlkqmsncsplIKAWSreCLCYCSWkeydflLMPgfmv 240
Cdd:cd17429 163 QGAVSLNLCVCGALMR------------LFTNKVFVA----------------FIFWA--LFAYCSF------VIP---- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 241 lavsvlfmaygcsplFVYLVPYALTVGVSHHQAAF-LMSILGVIDIVGNITFGWLTDRRCLKKYRHFcyLFAVGMDGLCC 319
Cdd:cd17429 203 ---------------FIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCISVWNVF--ILANFTLGVCI 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 320 LFLPVLQSFPLLVPFSFTFGYFDGaYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFL 399
Cdd:cd17429 266 LILPLMHTYTGLAIVCALIGFSSG-YFSLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFY 344
|
....
gi 1443618767 400 LCGF 403
Cdd:cd17429 345 VCGL 348
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
2-412 |
1.77e-40 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 149.34 E-value: 1.77e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 2 IVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLI 81
Cdd:cd17355 4 VLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 82 LSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMV-GKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLI 160
Cdd:cd17355 84 LLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVaAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 161 LGGfvlnlcVCGALMRPIALKEDRKTAPEFLEQDYVPDAQkqdlkqmSNCSPLIKAWSReclcycswkeydfllmPGFMV 240
Cdd:cd17355 164 LAL------LALLVLVPVLLLLRRRPADLALRAYDDASPA-------SPGSTLKEALRS----------------ASFWL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 241 LAVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRrcLKKYRHFCYLFAVGMDGLCCL 320
Cdd:cd17355 215 LALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR--YSPRRLLAASYALRALGLALL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 321 FLPVLQSFPLLVpFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLL 400
Cdd:cd17355 293 LLLPFPPLALLL-FAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWAL 371
|
410
....*....|..
gi 1443618767 401 CGFSMIFSSTLL 412
Cdd:cd17355 372 AVALGLIAALLV 383
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
37-414 |
8.72e-38 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 142.28 E-value: 8.72e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 37 RTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLILSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVG 116
Cdd:cd17420 44 KAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGAAVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 117 KYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPIAlkedrktapefleqdyV 196
Cdd:cd17420 124 HYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYGLEGTLRVLSLFMFVLILCSFTYRPLH----------------P 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 197 PDAQKQDLKQMSNCSPLIKAWSRECLCYCSWKEydfllmPGFMVLAVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFL 276
Cdd:cd17420 188 SPEDPKSKPGRRTLHSRINLFLRKIFNVEIFKR------KRYVIWALGIPLALFGYFVPYVHLMKFVKEEFFPGKDVNVP 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 277 MSILGVIDIVGNITFGWLTDRRCLKKyRHFCYLFAVGMDGLCCLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADV 356
Cdd:cd17420 262 LMCIGITSGIGRLIFGVIADMPPGVK-KMYLQVLSFVSIGLMSMMIPLCNSFGILISVCLVMGLFDGCFISIMAPIAFEL 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1443618767 357 VGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLLCGFSMIFSSTLLCF 414
Cdd:cd17420 341 VGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFF 398
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
1-415 |
1.49e-35 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 135.33 E-value: 1.49e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 1 MIVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGL 80
Cdd:cd17428 3 VIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAGGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 81 ILSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLI 160
Cdd:cd17428 83 MLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCLLI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 161 LGGFVLNLCVCGALMRpialkedrktapefLEQDYVpdaqkqdlkqmsncsplikawsreclcycswkeydfllmpgFMV 240
Cdd:cd17428 163 VGALALNLLACGSLMR--------------LFKNRV-----------------------------------------FSA 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 241 LAVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAF-LMSILGVIDIVGNITFGWLTDRRCLKKYrhFCYLFAVGMDGLCC 319
Cdd:cd17428 188 LFIAILLFDIGAFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWVNSL--YLYVLTLIGMGAAL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 320 LFLPVLQSFPLLVPFSFTFGYFDGAYvTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFL 399
Cdd:cd17428 266 LAIPFAKSYLTLAVLSAILGFLSGNW-SIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFY 344
|
410
....*....|....*.
gi 1443618767 400 LCGFSMIFSSTLLCFA 415
Cdd:cd17428 345 FSGFCVLLGGFLLLLA 360
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-420 |
3.65e-34 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 131.53 E-value: 3.65e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 1 MIVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGL 80
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 81 ILSSFATSLEHLYLSLgVLTGLGFALCYSPAIAMVGKYF-NRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALL 159
Cdd:COG2271 90 LLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 160 ILGGFVLnlcvcgalmrpialkedrktapefleqdyvpdaqkqdlkqmsncsplikawsreclcycswkeydFLLMPGFM 239
Cdd:COG2271 169 ILGLPGL-----------------------------------------------------------------LLALLRFW 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 240 VLAVSVLFMAYGCSPLFVYLVPYALTV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRrcLKKYRHFCYLFAVGMDGLC 318
Cdd:COG2271 184 LLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR--LGRRRKLVLAIGLLLAALA 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 319 CLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGsYTASF 398
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAF 340
|
410 420
....*....|....*....|..
gi 1443618767 399 LLCGFSMIFSSTLLCFARVAKK 420
Cdd:COG2271 341 LLLAALALLAALLALLLLRETR 362
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
1-414 |
5.45e-34 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 131.58 E-value: 5.45e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 1 MIVAGCFLVTICTRAVTrCISIFFVEFQTYFGQDYARTAWIHSIAD-CATMLCAPLGSLISNHvSCQVGIMLGGLLASTG 79
Cdd:cd17353 4 LVLLGAVLMHLILGYQY-AWSVFNPPLSSALGWSLASVALAFTLTIvFLAISAPFAGRLVDRG-GPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 80 LILSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALL 159
Cdd:cd17353 82 FILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 160 ILG-GFVLNLCVCGALMRPialkedrktaPEFLEQDYVPDAQKQDLKQmsncsPLIKAWSRECLcycswKEYDFLLMPGF 238
Cdd:cd17353 162 ILGiIFLIIIVIGAFLIRD----------PPKGWVPPGVDPLANNAEN-----SPRDYTPREML-----RTPTFWLLWLM 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 239 MVLAVSVLFMAYGcsplfvYLVPYALTV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRrcLKkyRHFCYLFAVGMDGL 317
Cdd:cd17353 222 FFLNATAGLMLIG------QAKPIGQEFaGLDAGIAALAVSILSIFNGGGRPFWGWLSDK--IG--RKNTLSIAFLIQGV 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 318 CCLFLP-VLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWlVDTTGSYTA 396
Cdd:cd17353 292 AMFLLPfIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAY-VLYTGGYNA 370
|
410
....*....|....*...
gi 1443618767 397 SFLLCGFSMIFSSTLLCF 414
Cdd:cd17353 371 AFIIAAALSLVALALALL 388
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-420 |
6.13e-34 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 131.54 E-value: 6.13e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 20 ISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLILSSFATSLEHLyLSLGVL 99
Cdd:COG2223 24 WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLL-LLLGLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 100 TGLGFALCYSPAIAMVGKYFN-RRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGAL-MRP 177
Cdd:COG2223 103 LGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLfLRD 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 178 IALKEDRKTAPEFLEQDYVpdaqkqdlkqmsncsplikawsreclcycsWKEYDFLLMPGFMVLAVSVLFMaygcspLFV 257
Cdd:COG2223 183 PPAGAAAAAKASLRDQLEA------------------------------LRDPRFWLLSLLYFGTFGSFIG------FSS 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 258 YLVPYALTV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRrcLKKYRHFCYLFAVGmdGLCCLFLP-VLQSFPLLVPFS 335
Cdd:COG2223 227 WLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDR--IGGRRVLLIVFALM--ALGLLLLAlALGSLWLFLVLF 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 336 FTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLLCGFSMIFSSTLLCFA 415
Cdd:COG2223 303 LLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLL 382
|
....*
gi 1443618767 416 RVAKK 420
Cdd:COG2223 383 YRRPR 387
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
20-415 |
6.58e-32 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 125.60 E-value: 6.58e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 20 ISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLILSSFATSLEHLYLSLGVL 99
Cdd:cd17314 22 WSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSFPLSYACFVF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 100 TGLGFALCYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPia 179
Cdd:cd17314 102 IGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSLLGF-- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 180 LKEDRKTAPEFLEQDYVpdaqkQDLKQMsncsplikawsreclcycswkeydfLLMPGFMVLAVSVLFMAYGCSPLFVYL 259
Cdd:cd17314 180 KEPPDNQARLHVQKKKT-----QTMGEI-------------------------FRDKVFWILFIAIFLVLIGGFLFIANM 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 260 VPYALTVGVSHHQ-AAFLMSILGVIDIVGNITFGWLTDRRcLKKYRHFCYLFAVGMDGLCCLFLPVLQSFPLLVPFSFTF 338
Cdd:cd17314 230 ASLVRSLQLDAPSfVTKLMSIYGLFNAFGRLLWGIVADFF-GGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLL 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1443618767 339 GYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLLCGFSMIFSSTLLCFA 415
Cdd:cd17314 309 GFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
37-414 |
1.84e-30 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 121.82 E-value: 1.84e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 37 RTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLILSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVG 116
Cdd:cd17464 44 KTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGAAVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 117 KYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPIALKEDRKTAPefleqdyv 196
Cdd:cd17464 124 HYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVGLFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGK-------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 197 pdaqkqdlKQMSNCSPLIKAWSreclcYCSWKeydfllMPGFMVLAVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFL 276
Cdd:cd17464 196 --------KRKFKCPPLKKIFN-----FNIWK------STGYRIWAFGIPAALFGYFVPYVHLMNHVKERFGEDVNKEVL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 277 MSILGVIDIVGNITFGWLTDrRCLKKYRHFCYLFAVGMDGLCCLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADV 356
Cdd:cd17464 257 LMCIGITSGIGRLIFGRVAD-YIPGVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCLFMGLFDGCFISIMAPIAFEL 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1443618767 357 VGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLLCGFSMIFSSTLLCF 414
Cdd:cd17464 336 VGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIILCF 393
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-406 |
7.88e-28 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 114.59 E-value: 7.88e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 1 MIVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGL 80
Cdd:COG2807 18 LLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 81 ILSSFATSLEHLYLSlGVLTGLGFALCYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLI 160
Cdd:COG2807 98 LLRSLAPSVALLLAG-TALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 161 LGGfvlnLCVCGALMRPIALKEDRKTAPefleqdyvPDAQKQDLKQMsncsplikawsreclcycsWKEYDFLLMPGFMV 240
Cdd:COG2807 177 WAL----LALLALLLWLPLLRRRPAAAA--------AAPAAASLRSL-------------------WRSPLAWLLTLFFG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 241 LavsVLFMAYGcspLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRclkKYRH-----FCYLFAVGMD 315
Cdd:COG2807 226 L---QSLLYYA---VVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL---GDRRpllllLGLLGLAGLL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 316 GLccLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSS-ALGVVYFLHAIpylvSPPVAGWLVDTTGSY 394
Cdd:COG2807 297 GL--LLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGmAQSVGYLLAAL----GPLLVGALHDATGSW 370
|
410
....*....|..
gi 1443618767 395 TASFLLCGFSMI 406
Cdd:COG2807 371 TAALLLLAALAV 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-375 |
1.73e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 103.90 E-value: 1.73e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 1 MIVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGL 80
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 81 ILSSFATSLEHLYLsLGVLTGLGFALCYSPAIAMVGKYF-NRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALL 159
Cdd:COG2814 90 LLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 160 ILGGfvlnLCVCGALMRPIALKEDRKTAPEFLEQDYVpdaqkqdlkqmsncsplikawsreclcycswkeyDFLLMPGFM 239
Cdd:COG2814 169 VNAV----LALLALLLLLRLLPESRPAARARLRGSLR----------------------------------ELLRRPRLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 240 VLAVSVLFMAYGCSPLFVYLVPYALTV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYrhfcYLFAVGMDGLC 318
Cdd:COG2814 211 LLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL----LLIGLLLLALG 286
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1443618767 319 CLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAI 375
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
7-381 |
3.33e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.41 E-value: 3.33e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 7 FLVTICTRAVTRCISIFFVEF-QTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLILSSF 85
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 86 ATSLEHLYLsLGVLTGLGFALCYSPAIAMVGKYFNR-RKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGF 164
Cdd:pfam07690 82 ASSLWLLLV-LRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 165 VLNLCVCGALMRPIALKEDRKTAPEFLEqdyvpdaqkqdlkqmsncsPLIKAWSreclcycswkeydFLLMPGFMVLAVS 244
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARL-------------------SLIVAWK-------------ALLRDPVLWLLLA 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 245 VLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYRHFCYLFAVGMdGLCCLFLPV 324
Cdd:pfam07690 209 LLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA-ALGLLLLSL 287
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1443618767 325 LQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSP 381
Cdd:pfam07690 288 TLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
7-412 |
1.87e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 92.87 E-value: 1.87e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 7 FLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLILSSFA 86
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 87 TSLEHLYLSLgVLTGLGFALCYSPAIAMVGKYFN-RRKALAYGIAMSGSGIGTFILAPVVQLLIEQ--FSWRGALLILGG 163
Cdd:cd06174 82 PSFWLLLLGR-FLLGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 164 FVLNLCVCGALMRPIALKEDRktapefleqdyvpdAQKQDLKQMSNCSPLIKAWSReclcycswkeydfllmPGFMVLAV 243
Cdd:cd06174 161 LALLAAILLLLVVPDPPESAR--------------AKNEEASSKSVLKLLKRVLKN----------------PGLWLLLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 244 SVLFMAYGCSPLFVYLVPYALT-VGVSHHQAAFLMSILGVIDIVGNITFGWLTDRrclKKYRHFCYLFAVGMDGLCCLFL 322
Cdd:cd06174 211 AIFLVNLAYYSFSTLLPLFLLDlGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR---LIGRKPLLLIGLLLMALGLALL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 323 PVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLLCG 402
Cdd:cd06174 288 LLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLA 367
|
410
....*....|
gi 1443618767 403 FSMIFSSTLL 412
Cdd:cd06174 368 VLLLLAAILL 377
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
37-414 |
4.22e-18 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 85.62 E-value: 4.22e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 37 RTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLILSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVG 116
Cdd:cd17465 44 KTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGAAVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 117 KYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCvcgalmrpialkedrktapeFLEQDYv 196
Cdd:cd17465 124 HYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIGLAHTFQVLSLFMFIQI--------------------FLSLTY- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 197 pdaqkqdlkqmsncspliKAWSRecLCYCSWkeydfllmpgfmvlAVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFL 276
Cdd:cd17465 183 ------------------KVFRR--KTYRIW--------------AFGIATAVLGYFVPYVHLMKYVEEEFKENKREWVL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 277 MSILGVIDIVGNITFGWLTDR-RCLKKYrhFCYLFAVGMDGLCCLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTAD 355
Cdd:cd17465 229 LVCIGASSGIGRLMSGKIGDLiPGLKKI--YLQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFE 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1443618767 356 VVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLLCGFSMIFSSTLLCF 414
Cdd:cd17465 307 LVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVLFF 365
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
31-412 |
5.06e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 82.62 E-value: 5.06e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 31 FGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLILSSFATSLEHLYLSLgVLTGLGFALCYSP 110
Cdd:cd17325 26 LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVWPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 111 AIAMVGKYF-NRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLnlcvCGALMRPIALKEDRKTAPe 189
Cdd:cd17325 105 AMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL----LALVLALLLLPEPRPPPN- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 190 fleqdyvpdaqKQDLKQMSNCSPLIKawsreclcycswkeydFLLMPGFMVLAVSVLFMAYGCSPLFVYLVPYALTV-GV 268
Cdd:cd17325 180 -----------KRAVSAARLRSGLRL----------------LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 269 SHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKyrhfcyLFAVGM--DGLCCLFLPVLQSFPLLVPFSFTFGYFDGAYV 346
Cdd:cd17325 233 SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP------LILIGLllSAVALLLLPLATSFWLLLLLLALLGLGLGLVF 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1443618767 347 TLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGsYTASFLLCGFSMIFSSTLL 412
Cdd:cd17325 307 PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLF 371
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
20-412 |
3.86e-16 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 79.54 E-value: 3.86e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 20 ISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLILSSFATSLEHLYLsLGVL 99
Cdd:cd17319 22 ISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV-LRFL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 100 TGLGFALCYSPAIAMVGKYFNRR-KALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFvlnlcvcGALMRPI 178
Cdd:cd17319 101 LGVAEAGFFPGAIKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLL-------GLLLAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 179 AlkedrktapefleqdyvpdaqkqdlkqmsncsplikawsreclcycswkeydFLLMPGFMVLAVSVLFMAYGCSpLFVY 258
Cdd:cd17319 174 W----------------------------------------------------WFYLRQVWGLALGYFGINYALY-GLLT 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 259 LVPYAL--TVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYRHFCYL-FAVGMDGLccLFLPVLQSFPLLVPFS 335
Cdd:cd17319 201 WLPTYLkqARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIgLLLAAVGL--LLAYLTTSPVVAVILL 278
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1443618767 336 FTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLLCGFSMIFSSTLL 412
Cdd:cd17319 279 SLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLV 355
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
71-413 |
2.43e-14 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 74.20 E-value: 2.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 71 LGGLLASTGLILSSFATSLEHLYLSLgVLTGLGFALCYSPAIAMVGKYF-NRRKALAYGIAMSGSGIGTFILAPVVQLLI 149
Cdd:cd17475 66 VGLLLMGAAALLMALVGSYPVLLVLL-FLVGAGYGSVQPGGGRAIMRWFpPRERGLAMGIRQTGVPLGGALAAALLPPLA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 150 EQFSWRGALLILGGfvlnLCVCGALMRPIALKEdrktapefleqdyvPDAQKQDLKQMSNCSPLIKAWSREclcycswke 229
Cdd:cd17475 145 LHYGWRAAFVVAGL----VSILAAVLFWLFYRE--------------PPAASAATESASTLLRSLKEVLRN--------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 230 ydfllmPGFMVLAVSVLFMAYGCSPLFVYLVPYAL-TVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYRHF-- 306
Cdd:cd17475 198 ------RDVWLIAIAGALLVAPQFALLTFLLLFLHdHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVlv 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 307 CYLFAVGMDGLCCLFLPVLQSFPLLVPFSFTFGYF----DGAYVTLIpvvtADVVGTSSLSSALGVVYFLHAIPYLVSPP 382
Cdd:cd17475 272 ITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFaigwNGLYLTLV----AESAGPEQAGTALGLANTINFIGIAIGPP 347
|
330 340 350
....*....|....*....|....*....|.
gi 1443618767 383 VAGWLVDTTGSYTASFLLCGFSMIFSSTLLC 413
Cdd:cd17475 348 LFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
241-425 |
1.05e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 59.74 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 241 LAVSVLFMAYGCSPLFVYLVPY-ALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKyrhfCYLFAVGMDGLCC 319
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRR----VLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 320 LFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGsYTASFL 399
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFL 155
|
170 180
....*....|....*....|....*.
gi 1443618767 400 LCGFSMIFSSTLLCFARVAKKIKKTR 425
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPK 181
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
27-425 |
2.28e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 59.10 E-value: 2.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 27 FQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLILSSFATSLEHLYLSLGVLtGLGFAL 106
Cdd:COG0738 34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLL-GLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 107 CYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQ---FSWRGALLILGGFVLNLCVCGALMRpialked 183
Cdd:COG0738 113 LDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSK------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 184 rktapefleqdyVPDAQKQDLKQMSNCSPLIKAwsreclcycsWKEYDFLLMPGFMVLAVSVLFMAYGCSPLFVylvpyA 263
Cdd:COG0738 186 ------------LPEIEEEEEEAAGSAASLKSL----------LKNPRLLLGGLAIFLYVGAEGAIGDWLPLYL-----K 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 264 LTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRclkKYRHFCYLFAVGMdGLCCLFLPVLQSFPLLVPFSFTFGYFDG 343
Cdd:COG0738 239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF---GPVRLLRLSALLA-AVGLLLALLAPGPWLALIGLALVGLGLS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 344 AYVTLIPVVTADVVGTSSlSSALGVVYFLHAIPYLVSPPVAGWLVDTTGsYTASFLLCGFSMIFsstLLCFARVAKKIKK 423
Cdd:COG0738 315 LMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFLVPLVCYLL---ILLLALALKRKRR 389
|
..
gi 1443618767 424 TR 425
Cdd:COG0738 390 KK 391
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
40-416 |
3.96e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 58.35 E-value: 3.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 40 WIHSIADCATMLCAPLGSLISNHVScQVGIMLGGLLAST-GLILSSFATSLEHLYLSLGVLtGLGFALCYSPAIAMVGKY 118
Cdd:cd17473 39 LLLTLPALFIALFAPLAGWLADRFG-RKRLLIAGLLLYGiGGVAGLFLDSLYALLASRALL-GIGVAGIMTLATALIGDY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 119 FN---RRKALAY-GIAMSGSGIgtfILAPVVQLLIEqFSWRGALLI-LGGFVLNLCVCgALMRPIALKEDRKTAPEFLEQ 193
Cdd:cd17473 117 FEgeeRAKMLGLqSAAMSLGGV---VFLLLGGALAE-IGWRAPFLVyLLALPVLILVL-LFLPEPARKSKSAASPGAATA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 194 DYVPDAQkqdlkqmsncsplikawsreclcycswkeydfLLMPGFMVLAVSVLFMAygcspLFVYLvPYALTV--GVSHH 271
Cdd:cd17473 192 AALPWKR--------------------------------VLPIYFLAFLAMLLFYV-----IPIQL-PFLLQErgGGSAA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 272 QAAFLMSILGVIDIVGNITFGWLTDRRClkkyRHFCYLFAVGMDGLCCLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPV 351
Cdd:cd17473 234 LIGLALAIASLAGAIGALLFGRLKRRLG----KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNS 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1443618767 352 VTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLLCGFSMIFSSTLLCFAR 416
Cdd:cd17473 310 WAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
241-446 |
6.71e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.59 E-value: 6.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 241 LAVSVLFMAYGCspLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRclkKYRHFcYLFAVGMDGLCCL 320
Cdd:cd17325 3 LALFLDMLGYGI--IIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRF---GRKRL-LLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 321 FLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGsYTASFLL 400
Cdd:cd17325 77 LFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLV 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1443618767 401 CGFSMIFSSTLLCFA-RVAKKIKKTRLQSLANDASTKQHIWTNGAIA 446
Cdd:cd17325 156 CAALALLALVLALLLlPEPRPPPNKRAVSAARLRSGLRLLLRDRRLL 202
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
238-414 |
1.28e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.52 E-value: 1.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 238 FMVLAVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYrhfcYLFAVGMDGL 317
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRV----LLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 318 CCLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGsYTAS 397
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWV 166
|
170
....*....|....*..
gi 1443618767 398 FLLCGFSMIFSSTLLCF 414
Cdd:COG2814 167 FLVNAVLALLALLLLLR 183
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
212-413 |
2.87e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 55.36 E-value: 2.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 212 PLIKAWsreCLCYCSWkEYDFLlMPGFMVLAVSVLFMA-----------YGCSPLFVYLVPYALTV----------GVSH 270
Cdd:cd17312 144 PILAAS---LASYYGW-RAAFL-VPGIVGLVVAIILFFflrdsppyvwvLSLAYAFVYIVRYACLDwgplylyevkGYSL 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 271 HQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYRHFCYLFAVGMDGLCCLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIP 350
Cdd:cd17312 219 IDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIG 298
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1443618767 351 VVTADVVGTSS-LSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTAsFLLCGFSMIFSSTLLC 413
Cdd:cd17312 299 GAAAQDIGRKEaAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTV-FYFLISAALLSVLLLL 361
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
240-407 |
4.17e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 54.87 E-value: 4.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 240 VLAVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRrclkKYRHFCYLFAVGMDGLCC 319
Cdd:cd17477 192 LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADR----FDRRRVLLGCALLGALAA 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 320 LFLPVLQSFP-LLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGS---YT 395
Cdd:cd17477 268 LLLPLVPGLPlALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPhglFL 347
|
170
....*....|..
gi 1443618767 396 ASFLLCGFSMIF 407
Cdd:cd17477 348 FLAAVALLFLLF 359
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
69-402 |
4.21e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 54.90 E-value: 4.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 69 IMLGGLLASTGLILSSFATSLEHLYLsLGVLTGLGFALCYSPAIAMVGKYF-NRRKALAYGIAMSGSGIGTFILAPVVQL 147
Cdd:cd17365 67 LLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLGAAMPNAITLVSEYApARRRSLAVTLMFCGYPLGAALGGFLAAA 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 148 LIEQFSWRGALLILGGFVLNLcvcgalmrpialkedrktapefleqdyvpdaqkqdlkqmsncsplikawsreclcycsw 227
Cdd:cd17365 146 LIPAFGWRSVFLLGGVPPLIL----------------------------------------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 228 keydFLLMPGFMVLAVS---VLFMAYGcspLFVYLvPYAL-TVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKY 303
Cdd:cd17365 167 ----LPLLRGTLLLWVTffmGLLLVYL---LNSWL-PKLMvEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 304 RhfcYLFAVGMDGLCCLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPV 383
Cdd:cd17365 239 L---ALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLL 315
|
330
....*....|....*....
gi 1443618767 384 AGWLVDTTGSYTASFLLCG 402
Cdd:cd17365 316 GGLLLAAGLGPESVFLALA 334
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
69-392 |
4.74e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.29 E-value: 4.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 69 IMLGGLLASTGLILSSFATSLEH-----LYLSLGVLTGLGFALCYSPAIAMVGKYFN--RRKALAYGIAMSGSGIGTFIL 141
Cdd:COG2211 84 ILIGAIPLALSFVLLFTAPDLSPtgkliYALVTYLLLGLAYTLVNIPYSALGAELTPdyEERTRLSSWRFAFAGLGGLLA 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 142 APVVQLLIEQF--SWRGALLILGGFVLNLCVCGALMRPIALKEDRKTAPEfleqdyvPDAQKQDLKQMSNCSPLIkawsr 219
Cdd:COG2211 164 SVLPPPLVAAFggDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE-------KVSLKESLKALLKNRPFL----- 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 220 eclcycswkeydfllmpgFMVLAVSVLFMAYGC-SPLFVYLVPYALtvGVSHHQAAFLMSILGVIDIVGNITFGWLTDRR 298
Cdd:COG2211 232 ------------------LLLLAYLLFFLALALvAALLLYYFKYVL--GLSAALVGLLLALYFLAALLGAPLWPRLAKRF 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 299 CLKKyrhfCYLFAVGMDGLCCLFLPVLQ--SFPLLVPFSFTFGYFDGAYVTLIPVVTADVV-------GTSSLSSALGVV 369
Cdd:COG2211 292 GKKK----AFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktGRRREGLYFGIF 367
|
330 340
....*....|....*....|...
gi 1443618767 370 YFLHAIPYLVSPPVAGWLVDTTG 392
Cdd:COG2211 368 TFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
27-413 |
6.46e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 54.48 E-value: 6.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 27 FQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLILSSFATSLEHLYLSLgVLTGLGFAL 106
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV-ALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 107 CYSPAIAMVGKYFNRRKALAYGIAMSGSGIGtFILAPVVQLLIEQFSWRGALLILggFVLNLCVCGALMRPIalkedrkt 186
Cdd:cd17478 101 FHPEGARLASQAAGGRRGLAMSIFSVGGNLG-FALGPLIAAALVALFGGLGLLIL--LIIPGLAVALLLLRL-------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 187 apefleQDYVPDAQKQDLKQMSNCSPLIKAWSreclcycswkeydFLLMPGFMVLAVSVLFMAygcspLFVYLVPYALTV 266
Cdd:cd17478 170 ------RPLKKPEAKKAAAKSSARSTLKGVWR-------------ALLLLLIIVFLRSWVLSS-----LTTFLPFYLVQR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 267 GVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYRHFCYLFAVGmdglcCLFLPVLQSFPLLVPFSFTFGYFDGAYV 346
Cdd:cd17478 226 GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAP-----FLLLFLLTPGIWSYILLVLAGFLLFASF 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 347 TLIPVVTADVVGTS-SLSSAL--GVVYFLHAIpylvSPPVAGWLVDTTGsYTASFLLCGFSMIFSSTLLC 413
Cdd:cd17478 301 PVTVVLAQELLPGNvGLASGLmmGLSFGLGGI----GAPVLGALADAFG-LESVLLILALLPLLGALLAF 365
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
2-388 |
8.86e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 54.28 E-value: 8.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 2 IVAGCFLVTICTRAVTRCISIFFVEFQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVScQVGIMLGG-LLASTGL 80
Cdd:TIGR00895 18 AIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIG-RRRVLLWSiLLFSVFT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 81 ILSSFATSLEHLyLSLGVLTGLGFALCYSPAIAMVGKYF-NRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALL 159
Cdd:TIGR00895 97 LLCALATNVTQL-LILRFLAGLGLGGLMPNLNALVSEYApKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFY 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 160 ILGGFVLNLCVCGALMRPIALKEDRKTAPEFLEQDYVPDAQKQDLKQMSNCSPLIKAWSreclcycSWKEYDFLLMPGFM 239
Cdd:TIGR00895 176 VGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQG-------TKRSVFKALFQGKT 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 240 VLAVSVLFMAYGCSPLFVYLV----PYAL-TVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYRHFCYLFAVgm 314
Cdd:TIGR00895 249 ARITVLLWLLYFMLLVGVYFLtnwlPKLMvELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAV-- 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1443618767 315 dglcclFLPV----LQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLV 388
Cdd:TIGR00895 327 ------FAVLvgstLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
50-298 |
1.25e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.71 E-value: 1.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 50 MLCAPLGSLISNHVSCQVGIMLGGLLASTGLILSSFATSLEHLYLsLGVLTGLGFALCYSPAIAMVGKYFN-RRKALAYG 128
Cdd:cd17324 48 ALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLL-ARALAGLAHGGFWAIAAAYAADLVPpEKRGRAIG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 129 IAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGgfVLNLCVCGALMRpialkedrktapefleqdYVPDAQKQDLKQMS 208
Cdd:cd17324 127 LVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA--VLALLAALLLWR------------------LLPSLPPKKPGSLG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 209 NCSPLIKAWSReclcycswkeydfllmPGFMVLAVSVLFMAYGCSPLFVYLVPYALTV-GVSHHQAAFLMSILGVIDIVG 287
Cdd:cd17324 187 LLSSLLLLLRN----------------PRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVG 250
|
250
....*....|.
gi 1443618767 288 NITFGWLTDRR 298
Cdd:cd17324 251 SPLAGRLADRG 261
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
233-412 |
1.43e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 53.37 E-value: 1.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 233 LLMPGFMVLAVSVLFMAYGCSPLFVYLVPYALTV--GVSHHQAAFLMSILGVIDIVGNITFGWLTDRRclkkYRHFCYLF 310
Cdd:cd17316 173 LLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTvlGLSPATSSLYLLLISLGALVGALIAGLLSDRI----GRKKTLVI 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 311 AVGMDGLCC--LFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLV 388
Cdd:cd17316 249 GLILSGILAlpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLL 328
|
170 180
....*....|....*....|....
gi 1443618767 389 DTTGSYTASFLLCGFSMIFSSTLL 412
Cdd:cd17316 329 ASTGGTGVPALILALLAIVALIVA 352
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
69-406 |
7.40e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 51.03 E-value: 7.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 69 IMLGGL-LASTGLILSSFATSLEHLyLSLGVLTGLGFALCYSPAIAMVGKYF---NRRKALAYGIAMSGSGIGTFilaPV 144
Cdd:cd17474 66 VLLPGLlLFGIGGLLCGLSDSFALL-LAGRALQGIGAAGLGPLALTLIGDLFeggERAKAMGLYEAALGLGIAVG---PL 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 145 VQLLIEQFSWRGALLILGGFVLNLCVCGALMrpiaLKEDRKTAPEFleqdyvpdaQKQDLKQMSNcsplikawsreclcy 224
Cdd:cd17474 142 LGGLLAAISWRYPFFLLAALIPVAFLAILFL----LPEPKEKAKSS---------SATKLRDLKK--------------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 225 cswkeydFLLMPGFMVLAVSVLFMAYGCSPLFVYL-VPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKY 303
Cdd:cd17474 194 -------ALRGRGLLTFLVSAFLYFFLYFAFLTYLpFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 304 rhfCYLFAVGMDGLCCLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPV 383
Cdd:cd17474 267 ---ILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLL 343
|
330 340
....*....|....*....|...
gi 1443618767 384 AGWLVDTTGSYTASFLLCGFSMI 406
Cdd:cd17474 344 FGLLLEIFGLSAPFLVGAAIALA 366
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
27-396 |
7.71e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.17 E-value: 7.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 27 FQTYFGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVGIMLGGLLASTGLILsSFATSLEHLYLSLGVLTGLGFAL 106
Cdd:cd17333 22 LEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL-IFATPSIYLFVVLMFLAGLGAGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 107 CYSPAIAMVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQ-FSWRGALLILGGFVLNLCVCgaLMRPIALKEDRK 185
Cdd:cd17333 101 LDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSeLSWSWAYLIIGLIYLLLAIL--ILLTLFPELPSA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 186 TAPEFLEQDYVPDAQKqdlkqmsncspliKAWSReclcycswkeydfllmpgFMVLAVSVLFMAYGCSPLFVYLVP-YAL 264
Cdd:cd17333 179 RNPQQSVGAFSASASR-------------LLRNP------------------SIILGALALFLYVGAETAFSSWVPsYLV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 265 TVGVSHHQ-AAFLMSILGVIDIVGNITFGWLTDRrclKKYRHfcYLFAVGMDGLCCLFLPVLQSFPLLVPFSFTF-GYFD 342
Cdd:cd17333 228 EKKHVSDGlAGYLLSGFWVGITIGRLLGGPISRR---IKPHT--LLVLSGSGALLGLLILLLAPTLVVGLVATALlGLFM 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1443618767 343 GAYVTLIPVVTADVVGTSSlSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTA 396
Cdd:cd17333 303 AALFPTILSLGISNLPYAK-GKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTA 355
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
239-412 |
1.52e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 50.23 E-value: 1.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 239 MVLAVSVLFMAYGCSPLFVYlvpYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRrclkKYRHFCYLFAVGMDGLC 318
Cdd:cd17370 205 YLLAVALFALGNFSFAFLIL---RAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDR----IGRKKLLILGYLSLALA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 319 CLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTgSYTASF 398
Cdd:cd17370 278 YLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI-SPSAAF 356
|
170
....*....|....
gi 1443618767 399 LLCGFSMIFSSTLL 412
Cdd:cd17370 357 LFSAVLALIALLLL 370
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
77-412 |
2.79e-06 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 49.54 E-value: 2.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 77 STGLILSSFATSLEHLYLSLgVLTGLGFALCYSPAIA-MVGKYFNRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWR 155
Cdd:PRK12307 94 SVGTGLSGLASGVIMLTLSR-FIVGMGMAGEYACASTyAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWR 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 156 GALLIlggfvlnlcvcgALMRPIALKEDRKTAPEFLEQDyvpDAQKQDLKQMSNcspliKAWSRECLCYCSWkeYDFLLM 235
Cdd:PRK12307 173 AAFFV------------GLLPVLLVIYIRARAPESKEWE---EAKLSGKGKHSQ-----SAWSVFSLSMKGL--FNRAQF 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 236 PGFMVLAVsVLFMAYGCS-PLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKyrhfcyLFAVGM 314
Cdd:PRK12307 231 PLTLCVFI-VLFSIFGANwPIFGLLPTYLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKK------TFSIGL 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 315 DG----LCCLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDT 390
Cdd:PRK12307 304 LMsflfIFPLFRIPQDNYLLLGACLFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGIT 383
|
330 340
....*....|....*....|..
gi 1443618767 391 TGSYTASFLLCGFsmiFSSTLL 412
Cdd:PRK12307 384 MGLGAALTFIVAF---WTATIL 402
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
20-166 |
3.00e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 49.04 E-value: 3.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 20 ISIFFVEFQTYFGQDYARTAWIHSiadcATMLCAPLGSLISNHVSCQVG----IMLGGLLASTGLILSSFATSLEHLYLs 95
Cdd:COG0477 33 VNVALPSIAADLGASSAQLGWIVS----AYLLGRAIGLLLFGRLGDRYGrkrvLLIGLLLFGLASLLCGLAPSPELLIA- 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1443618767 96 LGVLTGLGFALCYSPAIAMVGKYFN-RRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVL 166
Cdd:COG0477 108 ARALQGIGAGGLMPGALALIAELFPaRERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGL 179
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
51-400 |
3.58e-06 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 49.11 E-value: 3.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 51 LCAPLGSLISNHVSCQVGIMLGGLLASTGLILSSFATSLEHLYLSLGVLTGLGFALCYSPAIamVGKYFNRRKAL---AY 127
Cdd:cd17339 49 VFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIALLFLGTALAGAGIAVGNVLLPSL--IKRDFPRRVGLmtgLY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 128 GIAMS-GSGIGTFILAPVVQLLieQFSWRGALLILGGFVLnlcVCGALMRPIALKEDRKTAPefleqdyVPDAQKQDLkq 206
Cdd:cd17339 127 TTSMNlGAALASGLSVPLAQAL--GGGWRGALAIWALPAL---LALLIWLPQLRRRKRAAAA-------AAPLTKISV-- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 207 msncsplikawsreclcycsWKEydfllmpgfmVLAVSV-LFMayGCSPLFVY-----LVPYALTVGVSHHQAAFLMSIL 280
Cdd:cd17339 193 --------------------WRS----------PLAWQVtLFM--GLQSLLFYtlmawLPTILIDAGLSAATAGWLLSLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 281 GVIDIVGNITFGWLTDRrcLKKYRHFCYLFAVGM-DGLCCLFLPVLQSFPLLVPF-----SFTFGYfdgaYVTLIPVVTA 354
Cdd:cd17339 241 QLVGIPASLLVPILATR--LKNQRPIVVLLAVLFiIGVLGLLFAPTALALLWAVLlglggGAAFSL----ALTLISLRSS 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1443618767 355 DVVGTSSLSS-ALGVVYFLHAipylVSPPVAGWLVDTTGSYTASFLL 400
Cdd:cd17339 315 DPAEAAALSGmAQSVGYLLAA----LGPLLFGVLHDLTGSWTAPLVL 357
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
246-414 |
4.72e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.66 E-value: 4.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 246 LFMAYGCSPLFVYLVPYALTV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLK--KYRHFCYLFAVGMdGLCCLFL 322
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgRRRPWILIGAIPL-ALSFVLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 323 PVLQSFPLLVP----------FSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAI--PYLVSPPVAGWLVDT 390
Cdd:COG2211 99 FTAPDLSPTGKliyalvtyllLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLlaSVLPPPLVAAFGGDA 178
|
170 180
....*....|....*....|....
gi 1443618767 391 TGSYTASFLLCGFSMIFSSTLLCF 414
Cdd:COG2211 179 ALGYRLTALIFAVLGLLAFLLTFF 202
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
70-416 |
4.92e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 45.37 E-value: 4.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 70 MLGGLLASTGLILSSFATSLEHLYLSLGVLTGLGFALCYSPAIAMVGKYFNR-RKALAYGIAMSGSGIGTFILAPVVQ-L 147
Cdd:cd06180 67 IRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAaGRGHLIGLLFAGVGLGIALSGLLVPaG 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 148 LIEQFSWRGALLILGGFVLNLCVCGALMRPIAlkEDRKTAPEFLEQDyvpdaqkqdlkqmsncSPLIKAWSRECLCYcsw 227
Cdd:cd06180 147 LGGGLSWRAGWLALALLSAVLLLLSFLLLRRG--PSAPTEASAAESA----------------PGLNRPLWRLALAY--- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 228 keydFLLMPGFMVLAVsvlfmaygcsplfvYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKyrhfC 307
Cdd:cd06180 206 ----GLFGFGYIITAT--------------FLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRR----A 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 308 YLFAVGMDGLCCLFLPVLQSFPLLVPFSFTFGyfdGAYVTLIPVVTADV--VGTSSLSSALGVVYFLHAIPYLVSPPVAG 385
Cdd:cd06180 264 LAANLLVQAVGVLLPLLSPGPAGLVLSAVLFG---GTFMAITALVMALAreLAPPAAPRALALMTASFGVGQILGPLLAG 340
|
330 340 350
....*....|....*....|....*....|.
gi 1443618767 386 WLVDTTGSYTASfLLCGFSMIFSSTLLCFAR 416
Cdd:cd06180 341 WLADATGGFAPA-LILAAAALVVAALLALLV 370
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
51-392 |
2.53e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 43.13 E-value: 2.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 51 LCAPLGSLISNHVSCQVGIMLGGLLASTGLILSSFATSLEH---LYLSLGVLTGLGFALCYSpaiaMVGKYFNRRK-ALA 126
Cdd:TIGR00881 45 ISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVmaaLWALNGIFQGMGWPPCGR----TVTKWFSRSErGTW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 127 YGIAMSGSGIGTFILAPVVQLLIEQF-SWRGALLILGGfvlnLCVCGALMRPIALKEDRKTA--PEfLEQDYVPDAQKQD 203
Cdd:TIGR00881 121 VSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGI----IAIIVSLICFLLLRDSPQSCglPP-AEEMPNEEPDGDA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 204 LKQMSNCSPL-IKAWSreclcycswkeydFLLMPGFMVLA---VSVLFMAYGCSPLF-VYLVPyalTVGVSHHQAAFLMS 278
Cdd:TIGR00881 196 EKKEEELTKKqIFLQY-------------VLLNKVLWYISlgyVFVYVVRTGILDWSpLYLTQ---EKGFSKEKASWAFT 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 279 ILGVIDIVGNITFGWLTDRRCLKKYRHFCYLFAVGMdgLCCL---FLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTAD 355
Cdd:TIGR00881 260 LYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALI--IVSLlvyWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASE 337
|
330 340 350
....*....|....*....|....*....|....*..
gi 1443618767 356 VVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTG 392
Cdd:TIGR00881 338 LAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
240-414 |
2.57e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.98 E-value: 2.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 240 VLAVSVLFMAYGCSPLFVYLVPYALTV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYrhfcYLFAVGMDGLC 318
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAIYLHQQlGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPV----MLAGLLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 319 CLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASF 398
Cdd:cd17329 79 FALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLA 158
|
170
....*....|....*.
gi 1443618767 399 LLCGFSMIFSSTLLCF 414
Cdd:cd17329 159 AAVLFLLAALVLLFLL 174
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
238-412 |
3.83e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.60 E-value: 3.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 238 FMVLAVSVLFMAYGcsPLFVYLVPYALTV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRRclkKYRHFCYLFAVGMdG 316
Cdd:cd06173 212 LLLLALALFALLGG--ALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR---RRGRLLLIGALLL-G 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 317 LCCLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTA 396
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV 365
|
170
....*....|....*.
gi 1443618767 397 sFLLCGFSMIFSSTLL 412
Cdd:cd06173 366 -FLLAGALLLLAALLL 380
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
241-446 |
2.09e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 2.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 241 LAVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYrhfcYLFAVGMDGLCCL 320
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRL----LLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 321 FLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSPPVAGWLVDTTGsYTASFLL 400
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIV 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1443618767 401 CGFsMIFSSTLLCF---ARVAKKIKKTRLQSLANDASTKQHIWTNGAIA 446
Cdd:cd17489 156 AAV-LALLALLLVFlvkDPPPVAAEEAEAGTRAFRRLVEKKVLPPALIL 203
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
1-414 |
2.27e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 40.30 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 1 MIVAGCFLVTICTRAVTRCISIFFVEFqtyfGQDYARTAWIHSIADCATMLCAPLGSLISNHVSCQVG-----IMLGGLL 75
Cdd:cd17313 3 LLGFGFFGIEFGWALENSYVPPILQTL----GLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGrrrpfILVGAPL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 76 ASTGLILSSFATSLEHLYLSLG-----VLTGLGFAL-------CYSPAIAMVGKYFN---RRKALAYGIAMSGSG--IGT 138
Cdd:cd17313 79 AALGLILIPNAADIGLALGDGPrtwalVLFVLGIVLldfamnvCQGPVRALLPDLVPpeqRSKANGIINFMGGLGgvLGY 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 139 FILApVVQLLIEQFSWRGALL----ILGGFVLNLCVCGAL--MRPIALKEDRKTAPEFLEQDYVPDAQKQDLKQMSncSP 212
Cdd:cd17313 159 LLGA-ILWDHNWFGFALGGNLkvpfYIGAIILLVCVLVTLffVKEPPLSPEAGEHSENPSLGEVLKSLLKLLKIMP--RS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 213 LIKAWSRECLCYCSWkEYDFLLMPGFMVLAVSvlfmaYGCSPLFvylvpYALTVGVShhQAAFLMSILGVIDIVGNITFG 292
Cdd:cd17313 236 LLRLLLVIFFWWIAF-FPFELFFTDYMGEEVY-----HGTSAAS-----SHYGAGVR--MGAWGLLIFSLAFLIFSLPIG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 293 WLTDRRCLKKYrhfcYLFAVGMDGLCCLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTS--SLSSALGVVY 370
Cdd:cd17313 303 KLGKKIGRKKV----YLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESgrGQGTDTGLLN 378
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1443618767 371 FLHAIPYLVSPPVAGWLVDTTGsYTASFLLCGFSMIFSSTLLCF 414
Cdd:cd17313 379 LAISLAQILVSLLAGPIIDVKG-YGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
74-415 |
4.42e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.21 E-value: 4.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 74 LLASTGLILSSFATSLEHLyLSLGVLTGLGFALCYSPAIAMVGKYF-NRRKALAYGIAMSGSGIG----TFILAPVVQLL 148
Cdd:cd17371 72 LLFAVFTLLCGFAQNYWQL-LILRALAGLGFGGEWAAGAALMAEYVpARHRGKALGYVQSGWAVGwllaTLLAALLFPLL 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 149 IEQFSWRGaLLILGGFVLNLCVcgaLMRPiALKEdrktAPEFleqdyvpdAQKQDLKQMSNCSPLIkawsreclcycsWK 228
Cdd:cd17371 151 PPEIAWRV-LFLLGALPALLVL---FIRR-FVKE----PPQW--------QAARAARRHFADRPSL------------RE 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 229 EYDFLLMPGFM---VLAVSVLFMAYGCSPLFVYLVPYALtvGVSHHQAAFLMSILGVIDIVGNITFGWLTDRrcLKKYRH 305
Cdd:cd17371 202 LFSPPLLRTTLlasLLATGALGGYYGITTWLPSYLTGER--GLSFEGSAGYLVVTILGGFLGYLAGGFLADR--IGRRNN 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 306 FcYLFAVGmdglCCLFLPVLQSFP----LLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSSALGVVYFLHAIPYLVSP 381
Cdd:cd17371 278 F-ALFALG----SAISILLYFFLPlsptLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFP 352
|
330 340 350
....*....|....*....|....*....|....
gi 1443618767 382 PVAGWLVDTTGSYTASFLLCGFSMIFSSTLLCFA 415
Cdd:cd17371 353 FLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLL 386
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
69-407 |
5.12e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.08 E-value: 5.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 69 IMLGGLLAST-GLILSSFATSLEHLyLSLGVLTGLGFALCYSPAIAMVGKYFN-RRKALAYGIAMSGSGIGTFILAPVVQ 146
Cdd:cd17321 63 VFLIGLALFGlASLLCALAPSLAFL-IAARALQGIGAAAIMPASLALIAATFPgERRGRALGLWGAVVGIGAALGPLLGG 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 147 LLIEQFSWRGAllilggFVLNLCVCGALmrpialkedrktapefleqdyvpdaqkqdlkqmsncsplikawsreclcycs 226
Cdd:cd17321 142 LLLELFGWRWI------FLINVPIGLVA---------------------------------------------------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 227 wkeydFLLMPGFMVLAVSVLFMAYGCSPLFVYLVPYALTV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKYRH 305
Cdd:cd17321 164 -----LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVlGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 306 F-CYLFAVGMdgLCCLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVG-------------TSSLSSALGVVYF 371
Cdd:cd17321 239 AgLLLTAVGL--LLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPkekagaasgilntARQLGGALGVALL 316
|
330 340 350
....*....|....*....|....*....|....*.
gi 1443618767 372 LHAIPYLVSPPVAGWLVDTTGSYTASFLLCGFSMIF 407
Cdd:cd17321 317 GALLTAGLSANLGDSGVAALLSAAAAAFAAGFHLAF 352
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
237-408 |
5.71e-03 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 38.89 E-value: 5.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 237 GFMVLAVSVLFMAYGCSPLFVYLVPYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKyrhfCYLFAVGMDG 316
Cdd:pfam06779 194 PLWILTLAYGLAGFGYIITATFLPAMARDGFGGPAAAALFWSLFGLAAALGVLVWLRAAKRWGTRP----ALTAALLIQA 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 317 LCCLFLPVLQSFPLLVPFSFTFGYFDGAYVTLIPVVTADVVGTSSLSsALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTA 396
Cdd:pfam06779 270 LGVLLSLLSPSPAGLAVSSLLFGGTFMAITSLVMQLARELAPPAPRR-LLGLMTASFGIGQILGPLLASLLTAATGGLTP 348
|
170
....*....|..
gi 1443618767 397 SFLLCGFSMIFS 408
Cdd:pfam06779 349 ALLLAAAALVLA 360
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
27-408 |
7.31e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.71 E-value: 7.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 27 FQTYFGQDYARTAWIHSiadcATMLCAPLGSLISNHVSCQVG---IMLGGLLAST-GLILSSFATSLEHLYLSLgVLTGL 102
Cdd:cd17504 22 IQREFGTSAAAVSWVLT----AYLLVGAVSTPILGRLGDLYGrkkVLLIVLAIYTaGSLLAAFAPNLPVLIAGR-ALQGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 103 GFALcySP-AIAMVGKYF-NRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMrpial 180
Cdd:cd17504 97 GGAV--FPlAFALVREEFpPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI----- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 181 kedrktapefleqdyvpdaqkqDLKQMSNCSPLIkawsreclcycswkeydfLLMPGFMVLAvsVLFMAYGCSPLFVYLv 260
Cdd:cd17504 170 ----------------------DLRLLRRRNVLL------------------ANITALLAGF--GMFMVFQLLPQLLQL- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 261 PYALTVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKKyrhfCYLFAVGMDGLCCLFLPVLQSFPLLVPFSFTFGY 340
Cdd:cd17504 207 PTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRR----VLLIGLVISAVGLLLLALLHSSLWALVVALLLIG 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 341 --FDGAYVTLIPVVTAdVVGTSSLSSALGVVYFLHAIPYLVSPPVAG------------WLVDTTGSYTASFLLCGFSMI 406
Cdd:cd17504 283 igLGLAFASLPNIVVE-SVPPDRTGIATGMNTVLRTIGSAIGPAIAGailttytvsitsGGVPTEGAYVLAFLIGAALAL 361
|
..
gi 1443618767 407 FS 408
Cdd:cd17504 362 AA 363
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
285-403 |
9.93e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 37.92 E-value: 9.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443618767 285 IVGNITFGWLTDRRCLKKY-----RHFCYLFAVGMDGLCCLFLPVLQSFPLLVPF-SFTFGyFDGAYVTLIPVVTADVVG 358
Cdd:cd17380 226 FPSSNVAGWLADHLISRGWtvtsvRKLMQSIGFLGPALFLLLLSHTDSFSLALLCmSVALG-LSAFSSSGVLVNHQDIAP 304
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1443618767 359 TSSlSSALGVVYFLHAIPYLVSPPVAGWLVDTTGSYTASFLLCGF 403
Cdd:cd17380 305 NYA-GIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAV 348
|
|
| |
