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Conserved domains on  [gi|1494795020|ref|XP_026692580|]
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IgGFc-binding protein-like [Ciona intestinalis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 405-558 2.13e-24

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 100.91  E-value: 2.13e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020  405 CRGIGGSEYITFDHLHYSFAGRCQYQLAlttfnpfyAYSNNLQPFNISVTNDATRSGEP--RISVIKVTIAQRFVELHRN 482
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLA--------KDCSEEPDFSFSVTNKNCNGGASgvCLKSVTVIVGDLEITLQKG 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1494795020  483 RRVIVDGEQEILPIVLSGFRIDIRGR---FVTMTTTSGAVIKFDGETSFIIGLPTTYSGHVQGLCGNMNNDASDEFLDS 558
Cdd:pfam00094   73 GTVLVNGQKVSLPYKSDGGEVEILGSgfvVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTP 151
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1232-1382 1.56e-20

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 89.74  E-value: 1.56e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020 1232 CKAVTDPHYMTFDRTRFDSMGTCAYIMIRNIagSRAPNFTVIAVNVQPLPHQIVSHVKEVHLLFNGNETMVFQEGpVVKW 1311
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDC--SEEPDFSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQKGG-TVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1494795020 1312 NGRVILPGTTQSNF---VVTRGGRFIVVEFDFRLVIKWDGIDRVRIHAWQELREQVEGLCGDFDDDASNDFRTS 1382
Cdd:pfam00094   78 NGQKVSLPYKSDGGeveILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTP 151
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 795-948 9.40e-20

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 87.81  E-value: 9.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020  795 CHALGDPHYQTFDGAAFDSMSTCAHIMVRSRADSTitPFTVIAINDQPRINQTVSHVSEVHVVfgVNQTRITLKEGPVIM 874
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEP--DFSFSVTNKNCNGGASGVCLKSVTVI--VGDLEITLQKGGTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1494795020  875 VNGAIAYPGASFDGFTIRKLG---VFVILSFNFGLVVRWDGVDRLRISAwSPLSR-HVEGLCGNFDGDPTNDFAAANG 948
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGsgfVVVDLSPGVGLQVDGDGRGQLFVTL-SPSYQgKTCGLCGNYNGNQEDDFMTPDG 153
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1035-1098 1.06e-16

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 76.23  E-value: 1.06e-16
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1494795020  1035 CAILTSTTGPFAPCHGIINPRQDFKNCVFDLCAYGGNQSYMERILSSYDYDCRERNVTVTGWRE 1098
Cdd:smart00832    8 CGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRT 71
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1106-1166 1.55e-13

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 66.57  E-value: 1.55e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1494795020 1106 CSGNMVFSSCMSQCQATCSDPDRS-ICESnldlgtHCIEGCQCPNGFVQSSNNSgCVPQELC 1166
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPpPCTK------QCVEGCFCPEGYVRNSGGK-CVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 676-729 2.93e-13

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 65.80  E-value: 2.93e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1494795020  676 CLPNSRYVACGMSEPQTCANLNSPPLATTSCVEGCQCDEGYLLS-GEQCVHQSTC 729
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 603-668 5.47e-11

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 60.05  E-value: 5.47e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1494795020   603 ACSLLTATEGCFSQCHSVISPDPFYQSCITALCrSTVYQRTTLKIQIGSYADACQLESAEICNWRD 668
Cdd:smart00832    7 QCGILLSPRGPFAACHSVVDPEPFFENCVYDTC-ACGGDCECLCDALAAYAAACAEAGVCISPWRT 71
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1430-1495 9.30e-10

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 56.58  E-value: 9.30e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1494795020  1430 RECSVLMNRTGPFADCHTQVNPWSSFRDCLFDLCATNGSSALKDRIFSSYTTDCLGADRQPSdDWR 1495
Cdd:smart00832    6 SQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCIS-PWR 70
VWD super family cl47498
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1525-1600 1.28e-09

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


The actual alignment was detected with superfamily member pfam00094:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 58.54  E-value: 1.28e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1494795020 1525 MLLTWNGRVILPGTTQSNF---VVTRGGRFIVVEFDFRLVIKWDGIDRVRIHAWQELREQVEGLCGDFDDDASNDFRTS 1600
Cdd:pfam00094   73 GTVLVNGQKVSLPYKSDGGeveILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTP 151
 
Name Accession Description Interval E-value
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 405-558 2.13e-24

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 100.91  E-value: 2.13e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020  405 CRGIGGSEYITFDHLHYSFAGRCQYQLAlttfnpfyAYSNNLQPFNISVTNDATRSGEP--RISVIKVTIAQRFVELHRN 482
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLA--------KDCSEEPDFSFSVTNKNCNGGASgvCLKSVTVIVGDLEITLQKG 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1494795020  483 RRVIVDGEQEILPIVLSGFRIDIRGR---FVTMTTTSGAVIKFDGETSFIIGLPTTYSGHVQGLCGNMNNDASDEFLDS 558
Cdd:pfam00094   73 GTVLVNGQKVSLPYKSDGGEVEILGSgfvVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTP 151
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 391-559 8.33e-21

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 90.92  E-value: 8.33e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020   391 QTCFTVVVDQElkyCRGIGGSEYITFDHLHYSFAGRCQYQLALTtfnpfyAYSNNlqPFNISVTNDATRSGEPRISVIKV 470
Cdd:smart00216    1 WCCTQEECSPT---CSVSGDPHYTTFDGVAYTFPGNCYYVLAQD------CSSEP--TFSVLLKNVPCGGGATCLKSVKV 69

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020   471 TIAQRFVELHRNRR-VIVDGEQEILPIVLSGFRIDIRGR-FVTMTTTSGAVIK--FDGETSFIIGLPTTYSGHVQGLCGN 546
Cdd:smart00216   70 ELNGDEIELKDDNGkVTVNGQQVSLPYKTSDGSIQIRSSgGYLVVITSLGLIQvtFDGLTLLSVQLPSKYRGKTCGLCGN 149

                           170
                    ....*....|...
gi 1494795020   547 MNNDASDEFLDSR 559
Cdd:smart00216  150 FDGEPEDDFRTPD 162
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1232-1382 1.56e-20

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 89.74  E-value: 1.56e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020 1232 CKAVTDPHYMTFDRTRFDSMGTCAYIMIRNIagSRAPNFTVIAVNVQPLPHQIVSHVKEVHLLFNGNETMVFQEGpVVKW 1311
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDC--SEEPDFSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQKGG-TVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1494795020 1312 NGRVILPGTTQSNF---VVTRGGRFIVVEFDFRLVIKWDGIDRVRIHAWQELREQVEGLCGDFDDDASNDFRTS 1382
Cdd:pfam00094   78 NGQKVSLPYKSDGGeveILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTP 151
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1229-1382 2.89e-20

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 89.38  E-value: 2.89e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020  1229 RATCKAVTDPHYMTFDRTRFDSMGTCAYIMIRNiAGSRaPNFTVIAVNVQPLphQIVSHVKEVHLLFNGNETMVFQEGPV 1308
Cdd:smart00216    9 SPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQD-CSSE-PTFSVLLKNVPCG--GGATCLKSVKVELNGDEIELKDDNGK 84

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1494795020  1309 VKWNG-RVILPGTTQSNFV-VTRGGRFIVVEFDFRLV-IKWDGIDRVRIHAWQELREQVEGLCGDFDDDASNDFRTS 1382
Cdd:smart00216   85 VTVNGqQVSLPYKTSDGSIqIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTP 161
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 795-948 9.40e-20

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 87.81  E-value: 9.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020  795 CHALGDPHYQTFDGAAFDSMSTCAHIMVRSRADSTitPFTVIAINDQPRINQTVSHVSEVHVVfgVNQTRITLKEGPVIM 874
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEP--DFSFSVTNKNCNGGASGVCLKSVTVI--VGDLEITLQKGGTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1494795020  875 VNGAIAYPGASFDGFTIRKLG---VFVILSFNFGLVVRWDGVDRLRISAwSPLSR-HVEGLCGNFDGDPTNDFAAANG 948
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGsgfVVVDLSPGVGLQVDGDGRGQLFVTL-SPSYQgKTCGLCGNYNGNQEDDFMTPDG 153
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 784-948 6.35e-19

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 85.53  E-value: 6.35e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020   784 HCFERTLlPATCHALGDPHYQTFDGAAFDSMSTCAHIMVRSraDSTITPFTVIAINDQPRINQTvshvSEVHVVFGVNQT 863
Cdd:smart00216    2 CCTQEEC-SPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQD--CSSEPTFSVLLKNVPCGGGAT----CLKSVKVELNGD 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020   864 RITLK--EGPVIMVNGAIAYPGASFDGF-TIRKLGVFVILSFNFGLV-VRWDGVDRLRISAwSPLSR-HVEGLCGNFDGD 938
Cdd:smart00216   75 EIELKddNGKVTVNGQQVSLPYKTSDGSiQIRSSGGYLVVITSLGLIqVTFDGLTLLSVQL-PSKYRgKTCGLCGNFDGE 153

                           170
                    ....*....|
gi 1494795020   939 PTNDFAAANG 948
Cdd:smart00216  154 PEDDFRTPDG 163
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1035-1098 1.06e-16

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 76.23  E-value: 1.06e-16
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1494795020  1035 CAILTSTTGPFAPCHGIINPRQDFKNCVFDLCAYGGNQSYMERILSSYDYDCRERNVTVTGWRE 1098
Cdd:smart00832    8 CGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRT 71
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1106-1166 1.55e-13

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 66.57  E-value: 1.55e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1494795020 1106 CSGNMVFSSCMSQCQATCSDPDRS-ICESnldlgtHCIEGCQCPNGFVQSSNNSgCVPQELC 1166
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPpPCTK------QCVEGCFCPEGYVRNSGGK-CVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 676-729 2.93e-13

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 65.80  E-value: 2.93e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1494795020  676 CLPNSRYVACGMSEPQTCANLNSPPLATTSCVEGCQCDEGYLLS-GEQCVHQSTC 729
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1035-1097 5.76e-13

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 65.48  E-value: 5.76e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1494795020 1035 CAILTSTtGPFAPCHGIINPRQDFKNCVFDLCAYGGNQSYMERILSSYDYDCRERNVTVTGWR 1097
Cdd:pfam08742    2 CGLLSDS-GPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWR 63
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1106-1166 9.27e-13

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 64.33  E-value: 9.27e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1494795020 1106 CSGNMVFSSCMSQCQATCSDP-DRSICEsnldlgTHCIEGCQCPNGFVQSSNNSgCVPQELC 1166
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLsPPDVCP------EPCVEGCVCPPGFVRNSGGK-CVPPSDC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 676-729 7.95e-12

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 61.63  E-value: 7.95e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1494795020  676 CLPNSRYVACGMSEPQTCANLNSPPLATTSCVEGCQCDEGYLLSGE-QCVHQSTC 729
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNSGgKCVPPSDC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 603-668 5.47e-11

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 60.05  E-value: 5.47e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1494795020   603 ACSLLTATEGCFSQCHSVISPDPFYQSCITALCrSTVYQRTTLKIQIGSYADACQLESAEICNWRD 668
Cdd:smart00832    7 QCGILLSPRGPFAACHSVVDPEPFFENCVYDTC-ACGGDCECLCDALAAYAAACAEAGVCISPWRT 71
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1430-1495 9.30e-10

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 56.58  E-value: 9.30e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1494795020  1430 RECSVLMNRTGPFADCHTQVNPWSSFRDCLFDLCATNGSSALKDRIFSSYTTDCLGADRQPSdDWR 1495
Cdd:smart00832    6 SQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCIS-PWR 70
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1525-1600 1.28e-09

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 58.54  E-value: 1.28e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1494795020 1525 MLLTWNGRVILPGTTQSNF---VVTRGGRFIVVEFDFRLVIKWDGIDRVRIHAWQELREQVEGLCGDFDDDASNDFRTS 1600
Cdd:pfam00094   73 GTVLVNGQKVSLPYKSDGGeveILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTP 151
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 604-667 2.95e-09

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 54.69  E-value: 2.95e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1494795020  604 CSLLTATeGCFSQCHSVISPDPFYQSCITALCRSTvYQRTTLKIQIGSYADACQLESAEICNWR 667
Cdd:pfam08742    2 CGLLSDS-GPFAPCHSVVDPEPYFEACVYDMCSCG-GDDECLCAALAAYARACQAAGVCIGDWR 63
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1432-1496 2.42e-08

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 52.00  E-value: 2.42e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1494795020 1432 CSVLMNrTGPFADCHTQVNPWSSFRDCLFDLCATNGSSALKDRIFSSYTTDCLGADRQPSdDWRQ 1496
Cdd:pfam08742    2 CGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIG-DWRT 64
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1530-1600 3.54e-08

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 54.72  E-value: 3.54e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1494795020  1530 NGRVILPGTTQSNFV-VTRGGRFIVVEFDFRLV-IKWDGIDRVRIHAWQELREQVEGLCGDFDDDASNDFRTS 1600
Cdd:smart00216   89 GQQVSLPYKTSDGSIqIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTP 161
 
Name Accession Description Interval E-value
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 405-558 2.13e-24

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 100.91  E-value: 2.13e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020  405 CRGIGGSEYITFDHLHYSFAGRCQYQLAlttfnpfyAYSNNLQPFNISVTNDATRSGEP--RISVIKVTIAQRFVELHRN 482
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLA--------KDCSEEPDFSFSVTNKNCNGGASgvCLKSVTVIVGDLEITLQKG 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1494795020  483 RRVIVDGEQEILPIVLSGFRIDIRGR---FVTMTTTSGAVIKFDGETSFIIGLPTTYSGHVQGLCGNMNNDASDEFLDS 558
Cdd:pfam00094   73 GTVLVNGQKVSLPYKSDGGEVEILGSgfvVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTP 151
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 391-559 8.33e-21

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 90.92  E-value: 8.33e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020   391 QTCFTVVVDQElkyCRGIGGSEYITFDHLHYSFAGRCQYQLALTtfnpfyAYSNNlqPFNISVTNDATRSGEPRISVIKV 470
Cdd:smart00216    1 WCCTQEECSPT---CSVSGDPHYTTFDGVAYTFPGNCYYVLAQD------CSSEP--TFSVLLKNVPCGGGATCLKSVKV 69

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020   471 TIAQRFVELHRNRR-VIVDGEQEILPIVLSGFRIDIRGR-FVTMTTTSGAVIK--FDGETSFIIGLPTTYSGHVQGLCGN 546
Cdd:smart00216   70 ELNGDEIELKDDNGkVTVNGQQVSLPYKTSDGSIQIRSSgGYLVVITSLGLIQvtFDGLTLLSVQLPSKYRGKTCGLCGN 149

                           170
                    ....*....|...
gi 1494795020   547 MNNDASDEFLDSR 559
Cdd:smart00216  150 FDGEPEDDFRTPD 162
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1232-1382 1.56e-20

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 89.74  E-value: 1.56e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020 1232 CKAVTDPHYMTFDRTRFDSMGTCAYIMIRNIagSRAPNFTVIAVNVQPLPHQIVSHVKEVHLLFNGNETMVFQEGpVVKW 1311
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDC--SEEPDFSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQKGG-TVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1494795020 1312 NGRVILPGTTQSNF---VVTRGGRFIVVEFDFRLVIKWDGIDRVRIHAWQELREQVEGLCGDFDDDASNDFRTS 1382
Cdd:pfam00094   78 NGQKVSLPYKSDGGeveILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTP 151
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1229-1382 2.89e-20

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 89.38  E-value: 2.89e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020  1229 RATCKAVTDPHYMTFDRTRFDSMGTCAYIMIRNiAGSRaPNFTVIAVNVQPLphQIVSHVKEVHLLFNGNETMVFQEGPV 1308
Cdd:smart00216    9 SPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQD-CSSE-PTFSVLLKNVPCG--GGATCLKSVKVELNGDEIELKDDNGK 84

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1494795020  1309 VKWNG-RVILPGTTQSNFV-VTRGGRFIVVEFDFRLV-IKWDGIDRVRIHAWQELREQVEGLCGDFDDDASNDFRTS 1382
Cdd:smart00216   85 VTVNGqQVSLPYKTSDGSIqIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTP 161
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 795-948 9.40e-20

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 87.81  E-value: 9.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020  795 CHALGDPHYQTFDGAAFDSMSTCAHIMVRSRADSTitPFTVIAINDQPRINQTVSHVSEVHVVfgVNQTRITLKEGPVIM 874
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEP--DFSFSVTNKNCNGGASGVCLKSVTVI--VGDLEITLQKGGTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1494795020  875 VNGAIAYPGASFDGFTIRKLG---VFVILSFNFGLVVRWDGVDRLRISAwSPLSR-HVEGLCGNFDGDPTNDFAAANG 948
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGsgfVVVDLSPGVGLQVDGDGRGQLFVTL-SPSYQgKTCGLCGNYNGNQEDDFMTPDG 153
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 784-948 6.35e-19

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 85.53  E-value: 6.35e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020   784 HCFERTLlPATCHALGDPHYQTFDGAAFDSMSTCAHIMVRSraDSTITPFTVIAINDQPRINQTvshvSEVHVVFGVNQT 863
Cdd:smart00216    2 CCTQEEC-SPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQD--CSSEPTFSVLLKNVPCGGGAT----CLKSVKVELNGD 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494795020   864 RITLK--EGPVIMVNGAIAYPGASFDGF-TIRKLGVFVILSFNFGLV-VRWDGVDRLRISAwSPLSR-HVEGLCGNFDGD 938
Cdd:smart00216   75 EIELKddNGKVTVNGQQVSLPYKTSDGSiQIRSSGGYLVVITSLGLIqVTFDGLTLLSVQL-PSKYRgKTCGLCGNFDGE 153

                           170
                    ....*....|
gi 1494795020   939 PTNDFAAANG 948
Cdd:smart00216  154 PEDDFRTPDG 163
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1035-1098 1.06e-16

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 76.23  E-value: 1.06e-16
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1494795020  1035 CAILTSTTGPFAPCHGIINPRQDFKNCVFDLCAYGGNQSYMERILSSYDYDCRERNVTVTGWRE 1098
Cdd:smart00832    8 CGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRT 71
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1106-1166 1.55e-13

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 66.57  E-value: 1.55e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1494795020 1106 CSGNMVFSSCMSQCQATCSDPDRS-ICESnldlgtHCIEGCQCPNGFVQSSNNSgCVPQELC 1166
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPpPCTK------QCVEGCFCPEGYVRNSGGK-CVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 676-729 2.93e-13

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 65.80  E-value: 2.93e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1494795020  676 CLPNSRYVACGMSEPQTCANLNSPPLATTSCVEGCQCDEGYLLS-GEQCVHQSTC 729
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1035-1097 5.76e-13

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 65.48  E-value: 5.76e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1494795020 1035 CAILTSTtGPFAPCHGIINPRQDFKNCVFDLCAYGGNQSYMERILSSYDYDCRERNVTVTGWR 1097
Cdd:pfam08742    2 CGLLSDS-GPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWR 63
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1106-1166 9.27e-13

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 64.33  E-value: 9.27e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1494795020 1106 CSGNMVFSSCMSQCQATCSDP-DRSICEsnldlgTHCIEGCQCPNGFVQSSNNSgCVPQELC 1166
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLsPPDVCP------EPCVEGCVCPPGFVRNSGGK-CVPPSDC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 676-729 7.95e-12

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 61.63  E-value: 7.95e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1494795020  676 CLPNSRYVACGMSEPQTCANLNSPPLATTSCVEGCQCDEGYLLSGE-QCVHQSTC 729
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNSGgKCVPPSDC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 603-668 5.47e-11

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 60.05  E-value: 5.47e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1494795020   603 ACSLLTATEGCFSQCHSVISPDPFYQSCITALCrSTVYQRTTLKIQIGSYADACQLESAEICNWRD 668
Cdd:smart00832    7 QCGILLSPRGPFAACHSVVDPEPFFENCVYDTC-ACGGDCECLCDALAAYAAACAEAGVCISPWRT 71
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1430-1495 9.30e-10

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 56.58  E-value: 9.30e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1494795020  1430 RECSVLMNRTGPFADCHTQVNPWSSFRDCLFDLCATNGSSALKDRIFSSYTTDCLGADRQPSdDWR 1495
Cdd:smart00832    6 SQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCIS-PWR 70
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1525-1600 1.28e-09

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 58.54  E-value: 1.28e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1494795020 1525 MLLTWNGRVILPGTTQSNF---VVTRGGRFIVVEFDFRLVIKWDGIDRVRIHAWQELREQVEGLCGDFDDDASNDFRTS 1600
Cdd:pfam00094   73 GTVLVNGQKVSLPYKSDGGeveILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTP 151
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 604-667 2.95e-09

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 54.69  E-value: 2.95e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1494795020  604 CSLLTATeGCFSQCHSVISPDPFYQSCITALCRSTvYQRTTLKIQIGSYADACQLESAEICNWR 667
Cdd:pfam08742    2 CGLLSDS-GPFAPCHSVVDPEPYFEACVYDMCSCG-GDDECLCAALAAYARACQAAGVCIGDWR 63
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1432-1496 2.42e-08

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 52.00  E-value: 2.42e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1494795020 1432 CSVLMNrTGPFADCHTQVNPWSSFRDCLFDLCATNGSSALKDRIFSSYTTDCLGADRQPSdDWRQ 1496
Cdd:pfam08742    2 CGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIG-DWRT 64
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1530-1600 3.54e-08

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 54.72  E-value: 3.54e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1494795020  1530 NGRVILPGTTQSNFV-VTRGGRFIVVEFDFRLV-IKWDGIDRVRIHAWQELREQVEGLCGDFDDDASNDFRTS 1600
Cdd:smart00216   89 GQQVSLPYKTSDGSIqIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTP 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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