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Conserved domains on  [gi|1538011456|ref|XP_027263136|]
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slit homolog 1 protein [Cricetulus griseus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
1186-1319 3.70e-38

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 139.40  E-value: 3.70e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  1186 NITLQVSTAEDNGILLYNG---DNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGG 1262
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGskgGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1538011456  1263 SPMTMDNFGKHYTLNSEAPLYVGGMPVDvnsaaFRLWQILNGTSFHGCIRNLYINNE 1319
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPED-----LKLPPLPVTPGFRGCIRNLKVNGK 132
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-217 5.97e-29

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 121.58  E-value: 5.97e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   43 TTVDCHGTGLQAIPKNIPRNT--ERLELNGNNITRIHKnDFAGLKQLRVLQLMENQIGAVERgAFDDMKELERLRLNRNQ 120
Cdd:COG4886    116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  121 LHVLPELLfQNNQALSRLDLSENALQAVPrKAFRGATDLKNLQLDKNQISCIEEgaFRALRGLEVLTLNNNNITTIPVSS 200
Cdd:COG4886    194 ITDLPEPL-GNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269

                          170
                   ....*....|....*..
gi 1538011456  201 fnHMPKLRTFRLHSNHL 217
Cdd:COG4886    270 --NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
546-820 1.79e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.02  E-value: 1.79e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  546 RLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDgTFEGAASVSELHLTANQLESIRSGmFRGLDGLRTLMLRNNRI 625
Cdd:COG4886     94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQL 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  626 SCIhNDSFTGLRNVRLLSLYDNHITTIsPGAFDTLQALSTLNLlanpfncncqlawlgdwlrkrkivtgnprcqnpdflr 705
Cdd:COG4886    172 TDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDL------------------------------------- 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  706 qiplqdvafpdfrceegqeevgclprpqcpqecacldtvvrcSNKHLQALPKGIP--KNVTELYLDGNQFTLVPgQLSTF 783
Cdd:COG4886    213 ------------------------------------------SGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP-ELGNL 249

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1538011456  784 KYLQLVDLSNNKISSLSNSSftNMSQLTTLILSYNAL 820
Cdd:COG4886    250 TNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 644-730 5.41e-13

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 74.73  E-value: 5.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  644 LYDNHITTISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWLRKRKIVTGNPR---CQNPDFLRQIPLQDVAFPDFRCe 720
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGC- 80

                           90
                   ....*....|
gi 1538011456  721 eGQEEVGCLP 730
Cdd:TIGR00864   81 -DEEYVACLK 89
LRR_8 pfam13855
Leucine rich repeat;
312-369 1.55e-11

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 1.55e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1538011456  312 TEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKI 369
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 842-1002 8.43e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 67.41  E-value: 8.43e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  842 NDVSTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVK---TGYKEPGIARCAGPPDMEGKLLLTTPAKKFECqGPP 918
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC-DEE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  919 SLAvqakCDPCLSSpcqnQATCHNDPLEVYRCTCPSGYKGRDCEVSLDSCSSNPCGNGGT----CHTQEGEGAGFT---- 990
Cdd:TIGR00864   84 YVA----CLKDNSS----GGGAARSELVIFSAAHEGLFQPEACNAFCFSAGHGLAALGEQgeclCGAAQPSEANFAcesl 155

                          170
                   ....*....|..
gi 1538011456  991 CSCPSGFEGPTC 1002
Cdd:TIGR00864  156 CSGPPPPPAAAC 167
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 188-328 2.65e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 55.86  E-value: 2.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  188 LNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQ------RPTIglfTQCSGPASLRGLNVAEVQKSEF 261
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEA---ALCAGPGALAGQPLLGIPLLDS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  262 SC-----------SGQGESTRVPTCTLSSG--------SCPAMC-TCSSGIVDCRGKGLTAIPANLPETMTEIRLELNGI 321
Cdd:TIGR00864   79 GCdeeyvaclkdnSSGGGAARSELVIFSAAheglfqpeACNAFCfSAGHGLAALGEQGECLCGAAQPSEANFACESLCSG 158


                   ....*..
gi 1538011456  322 KSIPPGA 328
Cdd:TIGR00864  159 PPPPPAA 165
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1085-1119 3.96e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 3.96e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1538011456 1085 DDCKD-HRCQNGAQCVDEVNSYSCLCAEGYSGQFCE 1119
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1005-1041 2.68e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 2.68e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1538011456 1005 NTDDCV-KHACVNGGVCVDGVGNYTCRCPLQYTGRTCE 1041
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1044-1080 4.01e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 4.01e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1538011456 1044 VDFCSlDLNPCQHEAQCVGTPDGPRCECVPGYTGDNC 1080
Cdd:cd00054      2 IDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 414-475 3.45e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.93  E-value: 3.45e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1538011456  414 DNKIQSLTKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIET---SGARCASPRRLANK 475
Cdd:TIGR00864    4 NNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
LRRNT smart00013
Leucine rich repeat N-terminal domain;
512-542 2.17e-03

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.91  E-value: 2.17e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1538011456   512 ACPHKCRCEASVVECSSLKLSKIPERIPQST 542
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 733-760 2.33e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.84  E-value: 2.33e-03
                           10        20
                   ....*....|....*....|....*...
gi 1538011456  733 QCPQECACLDTVVRCSNKHLQALPKGIP 760
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
1186-1319 3.70e-38

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 139.40  E-value: 3.70e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  1186 NITLQVSTAEDNGILLYNG---DNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGG 1262
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGskgGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1538011456  1263 SPMTMDNFGKHYTLNSEAPLYVGGMPVDvnsaaFRLWQILNGTSFHGCIRNLYINNE 1319
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPED-----LKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1164-1317 3.11e-37

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 137.55  E-value: 3.11e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456 1164 GVNFvDRDTYLQFTDLQN-WPRANITLQVSTAEDNGILLYNGD---NDHIAVELYQGHVRVSYDPGSypSSAIYSAET-I 1238
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYDLGS--GSLVLSSKTpL 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1538011456 1239 NDGQFHTVELVTFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVnsaafRLWQILNGTSFHGCIRNLYIN 1317
Cdd:cd00110     78 NDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL-----KSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1191-1319 4.24e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.54  E-value: 4.24e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456 1191 VSTAEDNGILLYNGD--NDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGGSPMTMD 1268
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1538011456 1269 NFGKHYTLNSEAPLYVGGMPVDVnsaafRLWQILNGTSFHGCIRNLYINNE 1319
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLL-----LLPALPVRAGFVGCIRDVRVNGE 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-217 5.97e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 121.58  E-value: 5.97e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   43 TTVDCHGTGLQAIPKNIPRNT--ERLELNGNNITRIHKnDFAGLKQLRVLQLMENQIGAVERgAFDDMKELERLRLNRNQ 120
Cdd:COG4886    116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  121 LHVLPELLfQNNQALSRLDLSENALQAVPrKAFRGATDLKNLQLDKNQISCIEEgaFRALRGLEVLTLNNNNITTIPVSS 200
Cdd:COG4886    194 ITDLPEPL-GNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269

                          170
                   ....*....|....*..
gi 1538011456  201 fnHMPKLRTFRLHSNHL 217
Cdd:COG4886    270 --NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
546-820 1.79e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.02  E-value: 1.79e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  546 RLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDgTFEGAASVSELHLTANQLESIRSGmFRGLDGLRTLMLRNNRI 625
Cdd:COG4886     94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQL 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  626 SCIhNDSFTGLRNVRLLSLYDNHITTIsPGAFDTLQALSTLNLlanpfncncqlawlgdwlrkrkivtgnprcqnpdflr 705
Cdd:COG4886    172 TDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDL------------------------------------- 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  706 qiplqdvafpdfrceegqeevgclprpqcpqecacldtvvrcSNKHLQALPKGIP--KNVTELYLDGNQFTLVPgQLSTF 783
Cdd:COG4886    213 ------------------------------------------SGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP-ELGNL 249

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1538011456  784 KYLQLVDLSNNKISSLSNSSftNMSQLTTLILSYNAL 820
Cdd:COG4886    250 TNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
590-649 5.97e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.55  E-value: 5.97e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  590 SVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHI 649
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 644-730 5.41e-13

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 74.73  E-value: 5.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  644 LYDNHITTISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWLRKRKIVTGNPR---CQNPDFLRQIPLQDVAFPDFRCe 720
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGC- 80

                           90
                   ....*....|
gi 1538011456  721 eGQEEVGCLP 730
Cdd:TIGR00864   81 -DEEYVACLK 89
LRR_8 pfam13855
Leucine rich repeat;
159-217 1.47e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.70  E-value: 1.47e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1538011456  159 LKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
312-369 1.55e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 1.55e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1538011456  312 TEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKI 369
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 842-1002 8.43e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 67.41  E-value: 8.43e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  842 NDVSTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVK---TGYKEPGIARCAGPPDMEGKLLLTTPAKKFECqGPP 918
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC-DEE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  919 SLAvqakCDPCLSSpcqnQATCHNDPLEVYRCTCPSGYKGRDCEVSLDSCSSNPCGNGGT----CHTQEGEGAGFT---- 990
Cdd:TIGR00864   84 YVA----CLKDNSS----GGGAARSELVIFSAAHEGLFQPEACNAFCFSAGHGLAALGEQgeclCGAAQPSEANFAcesl 155

                          170
                   ....*....|..
gi 1538011456  991 CSCPSGFEGPTC 1002
Cdd:TIGR00864  156 CSGPPPPPAAAC 167
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
529-818 4.60e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 64.33  E-value: 4.60e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  529 LKLSKIPERIPQSTAELRLNNNEISILEATglfkKLSHLKKINLSNNKVSEIEDGTFEgaaSVSELHLTANQLESIRSgm 608
Cdd:PRK15370   188 LGLTTIPACIPEQITTLILDNNELKSLPEN----LQGNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITELPE-- 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  609 fRGLDGLRTLMLRNNRISCIHNDSFTGLRNvrlLSLYDNHITTIsPGAFDTlqALSTLNLLANpfncncQLAWLGDWLrk 688
Cdd:PRK15370   259 -RLPSALQSLDLFHNKISCLPENLPEELRY---LSVYDNSIRTL-PAHLPS--GITHLNVQSN------SLTALPETL-- 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  689 rkivtgnprcqnPDFLRQIplqdvafpdfrcEEGQEEVGCLPRpQCPQECACLDTvvrcSNKHLQALPKGIPKNVTELYL 768
Cdd:PRK15370   324 ------------PPGLKTL------------EAGENALTSLPA-SLPPELQVLDV----SKNQITVLPETLPPTITTLDV 374

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1538011456  769 DGNQFTLVPGQLSTfkYLQLVDLSNNKISSLSNS--SFTNMS-QLTTLILSYN 818
Cdd:PRK15370   375 SRNALTNLPENLPA--ALQIMQASRNNLVRLPESlpHFRGEGpQPTRIIVEYN 425
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-217 6.83e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.96  E-value: 6.83e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   66 LELNGNNITRIhkNDFAGLKQLRVLQLMENQIGAVErgAFDDMKELERLRLNRNQLHVLPELlfQNNQALSRLDLSENAL 145
Cdd:cd21340      7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENL--ENLVNLKKLYLGGNRI 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1538011456  146 QAVprKAFRGATDLKNLQLDKNQIS-----CIEEGAFRALRG-LEVLTLNNNNITTIpvSSFNHMPKLRTFRLHSNHL 217
Cdd:cd21340     81 SVV--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 530-673 3.55e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 3.55e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  530 KLSKIP--ERIPQSTaELRLNNNEISILEatGLfKKLSHLKKINLSNNKVSEIEDgtFEGAASVSELHLTANQLES---- 603
Cdd:cd21340     35 KITKIEnlEFLTNLT-HLYLQNNQIEKIE--NL-ENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPgekl 108

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1538011456  604 -IRSGMFRGL-DGLRTLMLRNNRISCIhnDSFTGLRNVRLLSLYDNHITTISP--GAFDTLQALSTLNLLANPF 673
Cdd:cd21340    109 tFDPRSLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
28-197 1.53e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.33  E-value: 1.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   28 RLGATACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRI-------------HKNDFAGLKQ-----LRV 89
Cdd:PRK15370   187 ILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIpatlpdtiqemelSINRITELPErlpsaLQS 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   90 LQLMENQIGAVERGAFDdmkELERLRLNRNQLHVLPELLfqnNQALSRLDLSENALQAVPRKAFRGatdLKNLQLDKNQI 169
Cdd:PRK15370   267 LDLFHNKISCLPENLPE---ELRYLSVYDNSIRTLPAHL---PSGITHLNVQSNSLTALPETLPPG---LKTLEAGENAL 337

                          170       180
                   ....*....|....*....|....*...
gi 1538011456  170 SCIEEGAFRALRgleVLTLNNNNITTIP 197
Cdd:PRK15370   338 TSLPASLPPELQ---VLDVSKNQITVLP 362
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 188-328 2.65e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 55.86  E-value: 2.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  188 LNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQ------RPTIglfTQCSGPASLRGLNVAEVQKSEF 261
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEA---ALCAGPGALAGQPLLGIPLLDS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  262 SC-----------SGQGESTRVPTCTLSSG--------SCPAMC-TCSSGIVDCRGKGLTAIPANLPETMTEIRLELNGI 321
Cdd:TIGR00864   79 GCdeeyvaclkdnSSGGGAARSELVIFSAAheglfqpeACNAFCfSAGHGLAALGEQGECLCGAAQPSEANFACESLCSG 158


                   ....*..
gi 1538011456  322 KSIPPGA 328
Cdd:TIGR00864  159 PPPPPAA 165
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1085-1119 3.96e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 3.96e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1538011456 1085 DDCKD-HRCQNGAQCVDEVNSYSCLCAEGYSGQFCE 1119
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
866-915 6.77e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 6.77e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1538011456   866 NPLYCDCHLRWLSSWV--KTGYKEPGIARCAGPPDMEGKLLLTTPAkKFECQ 915
Cdd:smart00082    1 NPFICDCELRWLLRWLqaNEHLQDPVDLRCASPSSLRGPLLELLHS-EFKCP 51
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1005-1041 2.68e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 2.68e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1538011456 1005 NTDDCV-KHACVNGGVCVDGVGNYTCRCPLQYTGRTCE 1041
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1044-1080 4.01e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 4.01e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1538011456 1044 VDFCSlDLNPCQHEAQCVGTPDGPRCECVPGYTGDNC 1080
Cdd:cd00054      2 IDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
1085-1119 7.12e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 7.12e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1538011456  1085 DDCK-DHRCQNGAQCVDEVNSYSCLCAEGYS-GQFCE 1119
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1002 9.88e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 9.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1538011456  966 DSCSS-NPCGNGGTCHTQEGegaGFTCSCPSGFEGPTC 1002
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVG---SYRCSCPPGYTGRNC 37
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-64 1.41e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.08  E-value: 1.41e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1538011456    33 ACPALCTCTGTTVDCHGTGLQAIPKNIPRNTE 64
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRCT smart00082
Leucine rich repeat C-terminal domain;
671-719 1.50e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.57  E-value: 1.50e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1538011456   671 NPFNCNCQLAWLGDWLRKRKIV--TGNPRCQNPDFLRQiPLQDVAFPDFRC 719
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRG-PLLELLHSEFKC 50
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
296-373 2.48e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 2.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  296 RGKGLTAIPANLPETMTEIRLELNGIKSIP---PGAfspyrkLRRIDLSNNQIAEIAPDAFQGLRSLNslvLYGNKITDL 372
Cdd:PRK15370   228 NSNQLTSIPATLPDTIQEMELSINRITELPerlPSA------LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRTL 298


                   .
gi 1538011456  373 P 373
Cdd:PRK15370   299 P 299
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 414-475 3.45e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.93  E-value: 3.45e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1538011456  414 DNKIQSLTKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIET---SGARCASPRRLANK 475
Cdd:TIGR00864    4 NNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
LRRNT smart00013
Leucine rich repeat N-terminal domain;
282-313 7.10e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 7.10e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1538011456   282 CPAMCTCSSGIVDCRGKGLTAIPANLPETMTE 313
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1087-1115 7.43e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 7.43e-05
                           10        20
                   ....*....|....*....|....*....
gi 1538011456 1087 CKDHRCQNGAQCVDEVNSYSCLCAEGYSG 1115
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 282-308 8.69e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 8.69e-05
                           10        20
                   ....*....|....*....|....*..
gi 1538011456  282 CPAMCTCSSGIVDCRGKGLTAIPANLP 308
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF_CA smart00179
Calcium-binding EGF-like domain;
1005-1041 1.09e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.09e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1538011456  1005 NTDDCV-KHACVNGGVCVDGVGNYTCRCPLQYT-GRTCE 1041
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
LRRNT smart00013
Leucine rich repeat N-terminal domain;
733-765 2.05e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.99  E-value: 2.05e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1538011456   733 QCPQECACLDTVVRCSNKHLQALPKGIPKNVTE 765
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRCT smart00082
Leucine rich repeat C-terminal domain;
439-469 3.14e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.11  E-value: 3.14e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1538011456   439 NPFICDCNLKWLADFLRTNPI--ETSGARCASP 469
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
299-420 3.48e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.46  E-value: 3.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  299 GLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRslnslvLYGNKITDLPRGVfg 378
Cdd:PRK15370   189 GLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEME------LSINRITELPERL-- 260

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1538011456  379 gLYTLQLLLLNANKINCIrPDTFQDlqSLSLLSLYDNKIQSL 420
Cdd:PRK15370   261 -PSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRTL 298
EGF_CA smart00179
Calcium-binding EGF-like domain;
1044-1080 5.53e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.53e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1538011456  1044 VDFCSLDlNPCQHEAQCVGTPDGPRCECVPGYT-GDNC 1080
Cdd:smart00179    2 IDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1050-1079 7.26e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 7.26e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1538011456 1050 DLNPCQHEAQCVGTPDGPRCECVPGYTGDN 1079
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 968-1001 1.42e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.42e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1538011456  968 CSSNPCGNGGTCHTqegEGAGFTCSCPSGFEGPT 1001
Cdd:pfam00008    1 CAPNPCSNGGTCVD---TPGGYTCICPEGYTGKR 31
LRRNT smart00013
Leucine rich repeat N-terminal domain;
512-542 2.17e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.91  E-value: 2.17e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1538011456   512 ACPHKCRCEASVVECSSLKLSKIPERIPQST 542
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 733-760 2.33e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.84  E-value: 2.33e-03
                           10        20
                   ....*....|....*....|....*...
gi 1538011456  733 QCPQECACLDTVVRCSNKHLQALPKGIP 760
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 512-539 4.68e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.07  E-value: 4.68e-03
                           10        20
                   ....*....|....*....|....*...
gi 1538011456  512 ACPHKCRCEASVVECSSLKLSKIPERIP 539
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1009-1039 4.94e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 4.94e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1538011456 1009 CVKHACVNGGVCVDGVGNYTCRCPLQYTGRT 1039
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
1186-1319 3.70e-38

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 139.40  E-value: 3.70e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  1186 NITLQVSTAEDNGILLYNG---DNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGG 1262
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGskgGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1538011456  1263 SPMTMDNFGKHYTLNSEAPLYVGGMPVDvnsaaFRLWQILNGTSFHGCIRNLYINNE 1319
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPED-----LKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1164-1317 3.11e-37

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 137.55  E-value: 3.11e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456 1164 GVNFvDRDTYLQFTDLQN-WPRANITLQVSTAEDNGILLYNGD---NDHIAVELYQGHVRVSYDPGSypSSAIYSAET-I 1238
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYDLGS--GSLVLSSKTpL 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1538011456 1239 NDGQFHTVELVTFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVnsaafRLWQILNGTSFHGCIRNLYIN 1317
Cdd:cd00110     78 NDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL-----KSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1191-1319 4.24e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.54  E-value: 4.24e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456 1191 VSTAEDNGILLYNGD--NDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGGSPMTMD 1268
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1538011456 1269 NFGKHYTLNSEAPLYVGGMPVDVnsaafRLWQILNGTSFHGCIRNLYINNE 1319
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLL-----LLPALPVRAGFVGCIRDVRVNGE 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-217 5.97e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 121.58  E-value: 5.97e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   43 TTVDCHGTGLQAIPKNIPRNT--ERLELNGNNITRIHKnDFAGLKQLRVLQLMENQIGAVERgAFDDMKELERLRLNRNQ 120
Cdd:COG4886    116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  121 LHVLPELLfQNNQALSRLDLSENALQAVPrKAFRGATDLKNLQLDKNQISCIEEgaFRALRGLEVLTLNNNNITTIPVSS 200
Cdd:COG4886    194 ITDLPEPL-GNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269

                          170
                   ....*....|....*..
gi 1538011456  201 fnHMPKLRTFRLHSNHL 217
Cdd:COG4886    270 --NLTNLKTLDLSNNQL 284
Laminin_G_1 pfam00054
Laminin G domain;
1191-1322 1.71e-28

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 111.64  E-value: 1.71e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456 1191 VSTAEDNGILLYNGDNDH---IAVELYQGHVRVSYDPGSYPSSaIYSAETINDGQFHTVELVTFDQMVNLSIDGG-SPMT 1266
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErdfLALELRDGRLEVSYDLGSGAAV-VRSGDKLNDGKWHSVELERNGRSGTLSVDGEaRPTG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1538011456 1267 MDNFGKHYTLNSEAPLYVGGMPVDVNSAafrlWQILNGTSFHGCIRNLYINNELQD 1322
Cdd:pfam00054   80 ESPLGATTDLDVDGPLYVGGLPSLGVKK----RRLAISPSFDGCIRDVIVNGKPLD 131
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-217 5.82e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 112.72  E-value: 5.82e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   62 NTERLELNGNNITRIhKNDFAGLKQLRVLQLMENQIGAVERgAFDDMKELERLRLNRNQLHVLPELLfQNNQALSRLDLS 141
Cdd:COG4886    114 NLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLS 190

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1538011456  142 ENALQAVPrKAFRGATDLKNLQLDKNQISCIEEgAFRALRGLEVLTLNNNNITTIPvsSFNHMPKLRTFRLHSNHL 217
Cdd:COG4886    191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-372 5.05e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.94  E-value: 5.05e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   55 IPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQigavergAFDDMKELERLRLNRNQLHVLPELLfQNNQA 134
Cdd:COG4886     66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEEL-ANLTN 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  135 LSRLDLSENALQAVPrKAFRGATDLKNLQLDKNQISCIEEgAFRALRGLEVLTLNNNNITTIPvSSFNHMPKLRTFRLHS 214
Cdd:COG4886    138 LKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSG 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  215 NHLfcdchlawlsqwlrqrptiglftqcsgpaslrglnvaevqksefscsgqgestrvptctlssgscpamctcssgivd 294
Cdd:COG4886    215 NQL----------------------------------------------------------------------------- 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  295 crgkglTAIPANLPE--TMTEIRLELNGIKSIPpgAFSPYRKLRRIDLSNNQIAEIAPDAfqGLRSLNSLVLYGNKITDL 372
Cdd:COG4886    218 ------TDLPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
546-820 1.79e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.02  E-value: 1.79e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  546 RLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDgTFEGAASVSELHLTANQLESIRSGmFRGLDGLRTLMLRNNRI 625
Cdd:COG4886     94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQL 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  626 SCIhNDSFTGLRNVRLLSLYDNHITTIsPGAFDTLQALSTLNLlanpfncncqlawlgdwlrkrkivtgnprcqnpdflr 705
Cdd:COG4886    172 TDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDL------------------------------------- 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  706 qiplqdvafpdfrceegqeevgclprpqcpqecacldtvvrcSNKHLQALPKGIP--KNVTELYLDGNQFTLVPgQLSTF 783
Cdd:COG4886    213 ------------------------------------------SGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP-ELGNL 249

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1538011456  784 KYLQLVDLSNNKISSLSNSSftNMSQLTTLILSYNAL 820
Cdd:COG4886    250 TNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-196 4.64e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.86  E-value: 4.64e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   43 TTVDCHGTGLQAIPKNIPRNT--ERLELNGNNITRIhKNDFAGLKQLRVLQLMENQIGAVErGAFDDMKELERLRLNRNQ 120
Cdd:COG4886    139 KELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQ 216

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1538011456  121 LHVLPELLfQNNQALSRLDLSENALQAVPrkAFRGATDLKNLQLDKNQISCIEEGAfrALRGLEVLTLNNNNITTI 196
Cdd:COG4886    217 LTDLPEPL-ANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
527-827 7.68e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.09  E-value: 7.68e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  527 SSLKLSKIPERIPQSTAELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGAASVSELHLTANQLesirs 606
Cdd:COG4886     34 LLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE----- 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  607 gmFRGLDGLRTLMLRNNRISCIhNDSFTGLRNVRLLSLYDNHITTIsPGAFDTLQALSTLNLLANPfncncqlawlgdwl 686
Cdd:COG4886    109 --LSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQ-------------- 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  687 rkrkivtgnprcqnpdfLRQIPlqdvafpdfrceegqEEVGCLPRpqcpqecacLdTVVRCSNKHLQALPKGI--PKNVT 764
Cdd:COG4886    171 -----------------LTDLP---------------EELGNLTN---------L-KELDLSNNQITDLPEPLgnLTNLE 208

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1538011456  765 ELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLsnSSFTNMSQLTTLILSYNALQCIPPLA 827
Cdd:COG4886    209 ELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLA 269
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
521-826 1.96e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.77  E-value: 1.96e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  521 ASVVECSSLKLSKIPErIPQSTA--ELRLNNNEISILEATglFKKLSHLKKINLSNNKVSEIEDgTFEGAASVSELHLTA 598
Cdd:COG4886     93 GDLTNLTELDLSGNEE-LSNLTNleSLDLSGNQLTDLPEE--LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSN 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  599 NQLESIRSGmFRGLDGLRTLMLRNNRISCIHnDSFTGLRNVRLLSLYDNHITTIsPGAFDTLQALSTLNLLANPfncncq 678
Cdd:COG4886    169 NQLTDLPEE-LGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ------ 239

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  679 lawlgdwlrkrkivtgnprcqnpdfLRQIPlqdvafpdfrceegqeEVGCLPrpqcpqecacldtvvrcsnkhlqalpkg 758
Cdd:COG4886    240 -------------------------LTDLP----------------ELGNLT---------------------------- 250

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1538011456  759 ipkNVTELYLDGNQFTLVPgQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPL 826
Cdd:COG4886    251 ---NLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
743-868 2.14e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 2.14e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  743 TVVRCSNKHLQALPKGIP--KNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSnSSFTNMSQLTTLILSYNAL 820
Cdd:COG4886    116 ESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQI 194

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1538011456  821 QCIPPlAFQGLRSLRLLSLHGNDVSTLQEGIfADVTSLSHLAIGANPL 868
Cdd:COG4886    195 TDLPE-PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
590-649 5.97e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.55  E-value: 5.97e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  590 SVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHI 649
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
312-674 1.30e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 1.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  312 TEIRLELNGIKSIPPgAFSPYRKLRRIDLSNNQIAEIaPDAFQGLRSLNSLVLYGNKITDLPRGVFGglytlqllLLNAN 391
Cdd:COG4886    116 ESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGN--------LTNLK 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  392 KINCirpdtfqdlqslsllslYDNKIQSLTKgTFTSLRAIQTLHLAQNpficdcnlkwladflrtnpietsgarcasprr 471
Cdd:COG4886    186 ELDL-----------------SNNQITDLPE-PLGNLTNLEELDLSGN-------------------------------- 215

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  472 lankrigqikskkfrcsakeqyfipgtedyhlnsectsdvacphkcrceasvvecsslKLSKIPERIPQSTA--ELRLNN 549
Cdd:COG4886    216 ----------------------------------------------------------QLTDLPEPLANLTNleTLDLSN 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  550 NEISILEAtglFKKLSHLKKINLSNNKVSEIEDgtFEGAASVSELHLTANQLESIR----SGMFRGLDGLRTLMLRNNRI 625
Cdd:COG4886    238 NQLTDLPE---LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLE 312

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1538011456  626 SCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPFN 674
Cdd:COG4886    313 LLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-203 1.61e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 1.61e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   43 TTVDCHGTGLQAIPKNIPRNT--ERLELNGNNITRIhKNDFAGLKQLRVLQLMENQIGAVErgAFDDMKELERLRLNRNQ 120
Cdd:COG4886    185 KELDLSNNQITDLPEPLGNLTnlEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQ 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  121 LHVLPELLfqNNQALSRLDLSENALQAVPRKAFRGATDLKNLQLDKNQISCIEEgaFRALRGLEVLTLNNNNITTIPVSS 200
Cdd:COG4886    262 LTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL--LILLLLLTTLLLLLLLLKGLLVTL 337


                   ...
gi 1538011456  201 FNH 203
Cdd:COG4886    338 TTL 340
LRR_8 pfam13855
Leucine rich repeat;
614-673 2.43e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 2.43e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  614 GLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPF 673
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 644-730 5.41e-13

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 74.73  E-value: 5.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  644 LYDNHITTISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWLRKRKIVTGNPR---CQNPDFLRQIPLQDVAFPDFRCe 720
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGC- 80

                           90
                   ....*....|
gi 1538011456  721 eGQEEVGCLP 730
Cdd:TIGR00864   81 -DEEYVACLK 89
LRR_8 pfam13855
Leucine rich repeat;
159-217 1.47e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.70  E-value: 1.47e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1538011456  159 LKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
565-625 4.43e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 4.43e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1538011456  565 SHLKKINLSNNKVSEIEDGTFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRI 625
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
312-369 1.55e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 1.55e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1538011456  312 TEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKI 369
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
736-868 1.55e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 1.55e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  736 QECACLDTVVRCSNKHLQALpkgipKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSnSSFTNMSQLTTLIL 815
Cdd:COG4886     93 GDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDL 166

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1538011456  816 SYNALQCIPPlAFQGLRSLRLLSLHGNDVSTLQEGIfADVTSLSHLAIGANPL 868
Cdd:COG4886    167 SNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQL 217
LRR_8 pfam13855
Leucine rich repeat;
135-193 1.76e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.76e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1538011456  135 LSRLDLSENALQAVPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNI 193
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
61-121 3.62e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 3.62e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1538011456   61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQL 121
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 842-1002 8.43e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 67.41  E-value: 8.43e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  842 NDVSTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVK---TGYKEPGIARCAGPPDMEGKLLLTTPAKKFECqGPP 918
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC-DEE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  919 SLAvqakCDPCLSSpcqnQATCHNDPLEVYRCTCPSGYKGRDCEVSLDSCSSNPCGNGGT----CHTQEGEGAGFT---- 990
Cdd:TIGR00864   84 YVA----CLKDNSS----GGGAARSELVIFSAAHEGLFQPEACNAFCFSAGHGLAALGEQgeclCGAAQPSEANFAcesl 155

                          170
                   ....*....|..
gi 1538011456  991 CSCPSGFEGPTC 1002
Cdd:TIGR00864  156 CSGPPPPPAAAC 167
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
529-818 4.60e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 64.33  E-value: 4.60e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  529 LKLSKIPERIPQSTAELRLNNNEISILEATglfkKLSHLKKINLSNNKVSEIEDGTFEgaaSVSELHLTANQLESIRSgm 608
Cdd:PRK15370   188 LGLTTIPACIPEQITTLILDNNELKSLPEN----LQGNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITELPE-- 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  609 fRGLDGLRTLMLRNNRISCIHNDSFTGLRNvrlLSLYDNHITTIsPGAFDTlqALSTLNLLANpfncncQLAWLGDWLrk 688
Cdd:PRK15370   259 -RLPSALQSLDLFHNKISCLPENLPEELRY---LSVYDNSIRTL-PAHLPS--GITHLNVQSN------SLTALPETL-- 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  689 rkivtgnprcqnPDFLRQIplqdvafpdfrcEEGQEEVGCLPRpQCPQECACLDTvvrcSNKHLQALPKGIPKNVTELYL 768
Cdd:PRK15370   324 ------------PPGLKTL------------EAGENALTSLPA-SLPPELQVLDV----SKNQITVLPETLPPTITTLDV 374

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1538011456  769 DGNQFTLVPGQLSTfkYLQLVDLSNNKISSLSNS--SFTNMS-QLTTLILSYN 818
Cdd:PRK15370   375 SRNALTNLPENLPA--ALQIMQASRNNLVRLPESlpHFRGEGpQPTRIIVEYN 425
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-217 6.83e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.96  E-value: 6.83e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   66 LELNGNNITRIhkNDFAGLKQLRVLQLMENQIGAVErgAFDDMKELERLRLNRNQLHVLPELlfQNNQALSRLDLSENAL 145
Cdd:cd21340      7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENL--ENLVNLKKLYLGGNRI 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1538011456  146 QAVprKAFRGATDLKNLQLDKNQIS-----CIEEGAFRALRG-LEVLTLNNNNITTIpvSSFNHMPKLRTFRLHSNHL 217
Cdd:cd21340     81 SVV--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154
LRR_8 pfam13855
Leucine rich repeat;
544-601 1.20e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 1.20e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1538011456  544 ELRLNNNEISILEAtGLFKKLSHLKKINLSNNKVSEIEDGTFEGAASVSELHLTANQL 601
Cdd:pfam13855    5 SLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
762-820 1.50e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 1.50e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  762 NVTELYLDGNQFTLV-PGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNAL 820
Cdd:pfam13855    2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
333-379 2.33e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 2.33e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1538011456  333 RKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGG 379
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG 47
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 530-673 3.55e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 3.55e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  530 KLSKIP--ERIPQSTaELRLNNNEISILEatGLfKKLSHLKKINLSNNKVSEIEDgtFEGAASVSELHLTANQLES---- 603
Cdd:cd21340     35 KITKIEnlEFLTNLT-HLYLQNNQIEKIE--NL-ENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPgekl 108

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1538011456  604 -IRSGMFRGL-DGLRTLMLRNNRISCIhnDSFTGLRNVRLLSLYDNHITTISP--GAFDTLQALSTLNLLANPF 673
Cdd:cd21340    109 tFDPRSLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
110-169 3.77e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 3.77e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  110 ELERLRLNRNQLHVLPELLFQNNQALSRLDLSENALQAVPRKAFRGATDLKNLQLDKNQI 169
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
28-197 1.53e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.33  E-value: 1.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   28 RLGATACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRI-------------HKNDFAGLKQ-----LRV 89
Cdd:PRK15370   187 ILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIpatlpdtiqemelSINRITELPErlpsaLQS 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   90 LQLMENQIGAVERGAFDdmkELERLRLNRNQLHVLPELLfqnNQALSRLDLSENALQAVPRKAFRGatdLKNLQLDKNQI 169
Cdd:PRK15370   267 LDLFHNKISCLPENLPE---ELRYLSVYDNSIRTLPAHL---PSGITHLNVQSNSLTALPETLPPG---LKTLEAGENAL 337

                          170       180
                   ....*....|....*....|....*...
gi 1538011456  170 SCIEEGAFRALRgleVLTLNNNNITTIP 197
Cdd:PRK15370   338 TSLPASLPPELQ---VLDVSKNQITVLP 362
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-217 1.74e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 1.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   43 TTVDCHGTGLQAIPK-NIPRNTERLELNGNNITRIhkNDFAGLKQLRVLQLMENQIGAVERgaFDDMKELERLRLNRNQ- 120
Cdd:cd21340      5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRi 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  121 -----LHVLPEL--LFQNNQALSR---LDLSENALQAVprkafrgATDLKNLQLDKNQISCIEEgaFRALRGLEVLTLNN 190
Cdd:cd21340     81 svvegLENLTNLeeLHIENQRLPPgekLTFDPRSLAAL-------SNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASN 151

                          170       180
                   ....*....|....*....|....*....
gi 1538011456  191 NNITTIP--VSSFNHMPKLRTFRLHSNHL 217
Cdd:cd21340    152 NQISDLEelLDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-217 2.37e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 2.37e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   55 IPKNIP--RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQI-GAVERGAFDdMKELERLRLNRNQ-LHVLPELLFQ 130
Cdd:PLN00113   396 IPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLqGRINSRKWD-MPSLQMLSLARNKfFGGLPDSFGS 474

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  131 NNqaLSRLDLSENALQ-AVPRKaFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNIT-TIPvSSFNHMPKLR 208
Cdd:PLN00113   475 KR--LENLDLSRNQFSgAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIP-ASFSEMPVLS 550


                   ....*....
gi 1538011456  209 TFRLHSNHL 217
Cdd:PLN00113   551 QLDLSQNQL 559
LRR_8 pfam13855
Leucine rich repeat;
786-832 4.48e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 4.48e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1538011456  786 LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLR 832
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP 49
LRR_8 pfam13855
Leucine rich repeat;
86-145 1.19e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 1.19e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   86 QLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHVLPELLFQNNQALSRLDLSENAL 145
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 188-328 2.65e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 55.86  E-value: 2.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  188 LNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQ------RPTIglfTQCSGPASLRGLNVAEVQKSEF 261
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEA---ALCAGPGALAGQPLLGIPLLDS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  262 SC-----------SGQGESTRVPTCTLSSG--------SCPAMC-TCSSGIVDCRGKGLTAIPANLPETMTEIRLELNGI 321
Cdd:TIGR00864   79 GCdeeyvaclkdnSSGGGAARSELVIFSAAheglfqpeACNAFCfSAGHGLAALGEQGECLCGAAQPSEANFACESLCSG 158


                   ....*..
gi 1538011456  322 KSIPPGA 328
Cdd:TIGR00864  159 PPPPPAA 165
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1085-1119 3.96e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 3.96e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1538011456 1085 DDCKD-HRCQNGAQCVDEVNSYSCLCAEGYSGQFCE 1119
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 545-701 4.98e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 4.98e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  545 LRLNNNEISILEATGLFKKLSHLkkiNLSNNKVSEIEDgtFEGAASVSELHLTANQLESIrSGmFRGLDGLRTLMLRNNR 624
Cdd:cd21340     29 LYLYDNKITKIENLEFLTNLTHL---YLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHIENQR 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  625 IS-----CIHNDSFTGLRN-VRLLSLYDNHITTISPgaFDTLQALSTLNLLANPFNCNCQLAW-LGDWLRKRKI-VTGNP 696
Cdd:cd21340    102 LPpgeklTFDPRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELdLTGNP 179


                   ....*
gi 1538011456  697 RCQNP 701
Cdd:cd21340    180 VCKKP 184
LRRCT smart00082
Leucine rich repeat C-terminal domain;
866-915 6.77e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 6.77e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1538011456   866 NPLYCDCHLRWLSSWV--KTGYKEPGIARCAGPPDMEGKLLLTTPAkKFECQ 915
Cdd:smart00082    1 NPFICDCELRWLLRWLqaNEHLQDPVDLRCASPSSLRGPLLELLHS-EFKCP 51
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
749-868 9.85e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 9.85e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  749 NKHLQALPKGIPKNVTELYLDGNQFTLVPGQLStfKYLQLVDLSNNKISSLSNSSftnMSQLTTLILSYNALQCIP---P 825
Cdd:PRK15370   208 NNELKSLPENLQGNIKTLYANSNQLTSIPATLP--DTIQEMELSINRITELPERL---PSALQSLDLFHNKISCLPenlP 282

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1538011456  826 LAFQglrslrLLSLHGNDVSTLQEGIfadVTSLSHLAIGANPL 868
Cdd:PRK15370   283 EELR------YLSVYDNSIRTLPAHL---PSGITHLNVQSNSL 316
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1005-1041 2.68e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 2.68e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1538011456 1005 NTDDCV-KHACVNGGVCVDGVGNYTCRCPLQYTGRTCE 1041
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1044-1080 4.01e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 4.01e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1538011456 1044 VDFCSlDLNPCQHEAQCVGTPDGPRCECVPGYTGDNC 1080
Cdd:cd00054      2 IDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 743-823 5.74e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 5.74e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  743 TVVRCSNKHLQALPK-GIPKNVTELYLDGNQFTLVPGqLSTFKYLQLVDLSNNKISSLSNssFTNMSQLTTLILSYNALQ 821
Cdd:cd21340      5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81


                   ..
gi 1538011456  822 CI 823
Cdd:cd21340     82 VV 83
EGF_CA smart00179
Calcium-binding EGF-like domain;
1085-1119 7.12e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 7.12e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1538011456  1085 DDCK-DHRCQNGAQCVDEVNSYSCLCAEGYS-GQFCE 1119
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 87-220 8.91e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.66  E-value: 8.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   87 LRVLQLMENQIGA-----VERGAFDDMKELERLRLNRNQLHVLP----ELLFQNNQALSRLDLSENAL--QAVPR--KAF 153
Cdd:cd00116    110 LQELKLNNNGLGDrglrlLAKGLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIgdAGIRAlaEGL 189

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1538011456  154 RGATDLKNLQLDKNQISCIE----EGAFRALRGLEVLTLNNNNITTIPVSSF-----NHMPKLRTFRLHSNHLFCD 220
Cdd:cd00116    190 KANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSCNDITDD 265
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1002 9.88e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 9.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1538011456  966 DSCSS-NPCGNGGTCHTQEGegaGFTCSCPSGFEGPTC 1002
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVG---SYRCSCPPGYTGRNC 37
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-64 1.41e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.08  E-value: 1.41e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1538011456    33 ACPALCTCTGTTVDCHGTGLQAIPKNIPRNTE 64
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRCT smart00082
Leucine rich repeat C-terminal domain;
671-719 1.50e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.57  E-value: 1.50e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1538011456   671 NPFNCNCQLAWLGDWLRKRKIV--TGNPRCQNPDFLRQiPLQDVAFPDFRC 719
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
181-217 1.85e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 1.85e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1538011456  181 RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL 37
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
296-373 2.48e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 2.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  296 RGKGLTAIPANLPETMTEIRLELNGIKSIP---PGAfspyrkLRRIDLSNNQIAEIAPDAFQGLRSLNslvLYGNKITDL 372
Cdd:PRK15370   228 NSNQLTSIPATLPDTIQEMELSINRITELPerlPSA------LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRTL 298


                   .
gi 1538011456  373 P 373
Cdd:PRK15370   299 P 299
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 50-217 2.59e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.63  E-value: 2.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   50 TGLQAIPKNIPRNTE--RLELNGNNITRIHKNDFA----GLKQLRVLQLMENQIGavERGA---FDDMKE---LERLRLN 117
Cdd:COG5238    195 EGIEELAEALTQNTTvtTLWLKRNPIGDEGAEILAealkGNKSLTTLDLSNNQIG--DEGVialAEALKNnttVETLYLS 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  118 RNQLHV-----LPELLfQNNQALSRLDLSEN--------ALQavprKAFRGATDLKNLQLDKNQISciEEGA---FRAL- 180
Cdd:COG5238    273 GNQIGAegaiaLAKAL-QGNTTLTSLDLSVNrigdegaiALA----EGLQGNKTLHTLNLAYNGIG--AQGAialAKALq 345

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1538011456  181 --RGLEVLTLNNNNITTIPVSSFNHMPKLRTfRLHSNHL 217
Cdd:COG5238    346 enTTLHSLDLSDNQIGDEGAIALAKYLEGNT-TLRELNL 383
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 414-475 3.45e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.93  E-value: 3.45e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1538011456  414 DNKIQSLTKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIET---SGARCASPRRLANK 475
Cdd:TIGR00864    4 NNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 927-962 5.96e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 5.96e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1538011456  927 DPCLS-SPCQNQATCHNDPlEVYRCTCPSGYKGRDCE 962
Cdd:cd00054      3 DECASgNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 561-818 6.54e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 6.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  561 FKKLSHLkkiNLSNNKVSEIEDgtfegaasvseLHLTANqlesirsgmfrgldgLRTLMLRNNRISCIHNdsFTGLRNVR 640
Cdd:cd21340      1 LKRITHL---YLNDKNITKIDN-----------LSLCKN---------------LKVLYLYDNKITKIEN--LEFLTNLT 49

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  641 LLSLYDNHITTISPgaFDTLQALSTLNLlanpfNCNCqlawlgdwlrkrkI--VTGnprCQNPDFLRQIPLqdvafpdfr 718
Cdd:cd21340     50 HLYLQNNQIEKIEN--LENLVNLKKLYL-----GGNR-------------IsvVEG---LENLTNLEELHI--------- 97

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  719 ceEGQeevgCLPRPQC-PQECACLDTVVRCsnkhLQALpkgipkNVTelyldGNQFTlVPGQLSTFKYLQLVDLSNNKIS 797
Cdd:cd21340     98 --ENQ----RLPPGEKlTFDPRSLAALSNS----LRVL------NIS-----GNNID-SLEPLAPLRNLEQLDASNNQIS 155

                          250       260
                   ....*....|....*....|...
gi 1538011456  798 SLSN--SSFTNMSQLTTLILSYN 818
Cdd:cd21340    156 DLEEllDLLSSWPSLRELDLTGN 178
LRRNT smart00013
Leucine rich repeat N-terminal domain;
282-313 7.10e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 7.10e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1538011456   282 CPAMCTCSSGIVDCRGKGLTAIPANLPETMTE 313
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1087-1115 7.43e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 7.43e-05
                           10        20
                   ....*....|....*....|....*....
gi 1538011456 1087 CKDHRCQNGAQCVDEVNSYSCLCAEGYSG 1115
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 282-308 8.69e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 8.69e-05
                           10        20
                   ....*....|....*....|....*..
gi 1538011456  282 CPAMCTCSSGIVDCRGKGLTAIPANLP 308
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF_CA smart00179
Calcium-binding EGF-like domain;
1005-1041 1.09e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.09e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1538011456  1005 NTDDCV-KHACVNGGVCVDGVGNYTCRCPLQYT-GRTCE 1041
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-60 1.39e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.30  E-value: 1.39e-04
                           10        20
                   ....*....|....*....|....*...
gi 1538011456   33 ACPALCTCTGTTVDCHGTGLQAIPKNIP 60
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 548-673 1.59e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 1.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  548 NNNEISILEATG---------LFKKLSHLKKINLSNNKVS-EIEDGTFEGAASVSELHLTANQLE-SIRSGMfrgLDGLR 616
Cdd:PLN00113    67 NSSRVVSIDLSGknisgkissAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGS---IPNLE 143

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  617 TLMLRNNRISC-IHND--SFTglrNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPF 673
Cdd:PLN00113   144 TLDLSNNMLSGeIPNDigSFS---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL 200
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 183-220 2.04e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.31  E-value: 2.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1538011456  183 LEVLTLNNNNITTIPvsSFNHMPKLRTFRLHSNHLFCD 220
Cdd:pfam12799    3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITD 38
LRRNT smart00013
Leucine rich repeat N-terminal domain;
733-765 2.05e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.99  E-value: 2.05e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1538011456   733 QCPQECACLDTVVRCSNKHLQALPKGIPKNVTE 765
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 334-373 2.75e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 2.75e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1538011456  334 KLRRIDLSNNQIAEIapDAFQGLRSLNSLVLYGN-KITDLP 373
Cdd:pfam12799    2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLS 40
LRRCT smart00082
Leucine rich repeat C-terminal domain;
439-469 3.14e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.11  E-value: 3.14e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1538011456   439 NPFICDCNLKWLADFLRTNPI--ETSGARCASP 469
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
299-420 3.48e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.46  E-value: 3.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  299 GLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRslnslvLYGNKITDLPRGVfg 378
Cdd:PRK15370   189 GLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEME------LSINRITELPERL-- 260

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1538011456  379 gLYTLQLLLLNANKINCIrPDTFQDlqSLSLLSLYDNKIQSL 420
Cdd:PRK15370   261 -PSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRTL 298
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-374 4.33e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 4.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLH-VLPELLFqNNQALSRLD 139
Cdd:PLN00113   212 KSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLD 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  140 LSENALQAVPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTL--------------NNNNITTIPVSSFNHMP 205
Cdd:PLN00113   291 LSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLwsnkfsgeipknlgKHNNLTVLDLSTNNLTG 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  206 KLRTFRLHSNHLFcdcHLAWLSQWLRQRPtiglftqcsgPASL---RGLNVAEVQKSEFSCSGQGESTRVPTCTLSSGSC 282
Cdd:PLN00113   371 EIPEGLCSSGNLF---KLILFSNSLEGEI----------PKSLgacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISN 437

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  283 PAMctcsSGIVDCRGKGLTaipanlpeTMTEIRLELNGIKSIPPGAFSPyRKLRRIDLSNNQIAEIAPDAFQGLRSLNSL 362
Cdd:PLN00113   438 NNL----QGRINSRKWDMP--------SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQL 504

                          330
                   ....*....|...
gi 1538011456  363 VLYGNKIT-DLPR 374
Cdd:PLN00113   505 KLSENKLSgEIPD 517
EGF_CA smart00179
Calcium-binding EGF-like domain;
1044-1080 5.53e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.53e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1538011456  1044 VDFCSLDlNPCQHEAQCVGTPDGPRCECVPGYT-GDNC 1080
Cdd:smart00179    2 IDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1052-1079 6.29e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.61  E-value: 6.29e-04
                           10        20
                   ....*....|....*....|....*...
gi 1538011456 1052 NPCQHEAQCVGTPDGPRCECVPGYTGDN 1079
Cdd:cd00053      6 NPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
966-1002 7.00e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 7.00e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1538011456   966 DSCSS-NPCGNGGTCHTQEGegaGFTCSCPSGFE-GPTC 1002
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVG---SYRCECPPGYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1050-1079 7.26e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 7.26e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1538011456 1050 DLNPCQHEAQCVGTPDGPRCECVPGYTGDN 1079
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
LRRCT smart00082
Leucine rich repeat C-terminal domain;
219-264 8.07e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.95  E-value: 8.07e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 1538011456   219 CDCHLAWLSQWLRQRPTIGLF--TQCSGPASLRGLnVAEVQKSEFSCS 264
Cdd:smart00082    5 CDCELRWLLRWLQANEHLQDPvdLRCASPSSLRGP-LLELLHSEFKCP 51
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 544-627 9.53e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 9.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  544 ELRLNNNEISILEATGL---FKKLSHLKKINLSNNKVSEIEDGTFEGA----ASVSELHLTANQLES-----IRSGMFRG 611
Cdd:cd00116    169 ELNLANNGIGDAGIRALaegLKANCNLEVLDLNNNGLTDEGASALAETlaslKSLEVLNLGDNNLTDagaaaLASALLSP 248

                           90
                   ....*....|....*.
gi 1538011456  612 LDGLRTLMLRNNRISC 627
Cdd:cd00116    249 NISLLTLSLSCNDITD 264
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1090-1119 9.79e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.23  E-value: 9.79e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1538011456 1090 HRCQNGAQCVDEVNSYSCLCAEGYSGQF-CE 1119
Cdd:cd00053      6 NPCSNGGTCVNTPGSYRCVCPPGYTGDRsCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 968-1001 1.42e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.42e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1538011456  968 CSSNPCGNGGTCHTqegEGAGFTCSCPSGFEGPT 1001
Cdd:pfam00008    1 CAPNPCSNGGTCVD---TPGGYTCICPEGYTGKR 31
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 544-582 1.73e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 1.73e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1538011456  544 ELRLNNNEISILEatgLFKKLSHLKKINLS-NNKVSEIED 582
Cdd:pfam12799    5 VLDLSNNQITDIP---PLAKLPNLETLDLSgNNKITDLSD 41
LRRNT smart00013
Leucine rich repeat N-terminal domain;
512-542 2.17e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.91  E-value: 2.17e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1538011456   512 ACPHKCRCEASVVECSSLKLSKIPERIPQST 542
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1092-1113 2.28e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.93  E-value: 2.28e-03
                           10        20
                   ....*....|....*....|..
gi 1538011456 1092 CQNGAQCVDEVNSYSCLCAEGY 1113
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 733-760 2.33e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.84  E-value: 2.33e-03
                           10        20
                   ....*....|....*....|....*...
gi 1538011456  733 QCPQECACLDTVVRCSNKHLQALPKGIP 760
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 567-657 3.66e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.07  E-value: 3.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  567 LKKINLSNNkVSEIEDGTFEGAASVSELHLTaNQLESIRSGMFRGLdGLRTLMLRNNrISCIHNDSFTGLRNVRLLSLYD 646
Cdd:pfam13306   13 LTSITIPSS-LTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITLPS 88

                           90
                   ....*....|.
gi 1538011456  647 NhITTISPGAF 657
Cdd:pfam13306   89 N-LTSIGSYAF 98
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 969-1001 3.85e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 3.85e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1538011456  969 SSNPCGNGGTCHTQEGegaGFTCSCPSGFEGPT 1001
Cdd:cd00053      4 ASNPCSNGGTCVNTPG---SYRCVCPPGYTGDR 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 615-654 4.00e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 4.00e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1538011456  615 LRTLMLRNNRISCIhnDSFTGLRNVRLLSLYDN-HITTISP 654
Cdd:pfam12799    3 LEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLSD 41
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 512-539 4.68e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.07  E-value: 4.68e-03
                           10        20
                   ....*....|....*....|....*...
gi 1538011456  512 ACPHKCRCEASVVECSSLKLSKIPERIP 539
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1009-1039 4.94e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 4.94e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1538011456 1009 CVKHACVNGGVCVDGVGNYTCRCPLQYTGRT 1039
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
LRR_8 pfam13855
Leucine rich repeat;
637-668 5.37e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 5.37e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1538011456  637 RNVRLLSLYDNHITTISPGAFDTLQALSTLNL 668
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDL 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
927-962 6.17e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 6.17e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1538011456   927 DPCLS-SPCQNQATCHNDPLEvYRCTCPSGYK-GRDCE 962
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGS-YRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1012-1041 6.81e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 6.81e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1538011456 1012 HACVNGGVCVDGVGNYTCRCPLQYTG-RTCE 1041
Cdd:cd00053      6 NPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
PLN03150 PLN03150
hypothetical protein; Provisional
 776-820 7.16e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 7.16e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1538011456  776 VPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNAL 820
Cdd:PLN03150   434 IPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSF 478
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 761-825 7.34e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 7.34e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1538011456  761 KNVTELYLDGNQFTLVPGqLSTFKYLQLVDLSNNKISSLSNssFTNMSQLTTLILSYnalQCIPP 825
Cdd:cd21340     46 TNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIEN---QRLPP 104
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 749-825 7.81e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 7.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456  749 NKHLQALPKGIPK--NVTELYLDGNQFT-LVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQC-IP 824
Cdd:PLN00113   485 NQFSGAVPRKLGSlsELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGeIP 564


                   .
gi 1538011456  825 P 825
Cdd:PLN00113   565 K 565
LRR smart00370
Leucine-rich repeats, outliers;
180-203 7.86e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 7.86e-03
                            10        20
                    ....*....|....*....|....
gi 1538011456   180 LRGLEVLTLNNNNITTIPVSSFNH 203
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
180-203 7.86e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 7.86e-03
                            10        20
                    ....*....|....*....|....
gi 1538011456   180 LRGLEVLTLNNNNITTIPVSSFNH 203
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-150 8.19e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 8.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538011456   66 LELNGNNITRIhkNDFAGLKQLRVLQLMENQIgavergafDDMKELERlrlnrnqlhvlpelLFQNNQALSRLDLSENAL 145
Cdd:cd21340    125 LNISGNNIDSL--EPLAPLRNLEQLDASNNQI--------SDLEELLD--------------LLSSWPSLRELDLTGNPV 180


                   ....*
gi 1538011456  146 QAVPR 150
Cdd:cd21340    181 CKKPK 185
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 929-960 9.74e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 9.74e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1538011456  929 CLSSPCQNQATCHNDPlEVYRCTCPSGYKGRD 960
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 930-962 9.80e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.15  E-value: 9.80e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1538011456  930 LSSPCQNQATCHNDPlEVYRCTCPSGYKG-RDCE 962
Cdd:cd00053      4 ASNPCSNGGTCVNTP-GSYRCVCPPGYTGdRSCE 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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