|
Name |
Accession |
Description |
Interval |
E-value |
| Mcm2 |
COG1241 |
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ... |
86-783 |
0e+00 |
|
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];
Pssm-ID: 440854 [Multi-domain] Cd Length: 682 Bit Score: 564.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 86 IEKIQAFEKFFTRHIdfYdKDEI-------ERKGSILVDFKELTKDDeitnliPDIENTLRDTPEKTLACMGLAIHQVLT 158
Cdd:COG1241 3 SDLVDKFEEFLRRYK--Y-RDEIlelaqeyPEKRSLVVDYNDLYSFD------PDLADDLLENPDEVLEAAEEALREIDL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 159 KDLEqhaaelqaqeglssdgetmVNVPHIFARVYNYEPLTHLKNVRANCYGKYISIRGTVVRVGNIKPLCTKMAFRCAAC 238
Cdd:COG1241 74 EPYD-------------------VSLGDAHVRITNLPETVPIRDIRSDHIGKLISVEGIVRKATEVKPKITEAAFECPRC 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 239 GEIQSFPLPDGKYNLPTKCPVpaC-RGKSFTPLRSSplTVTVDWQLIKIQELMSDAqrEAGRIPRTIECELVHDLVDSCV 317
Cdd:COG1241 135 GTETYVPQTGEKLQEPHECPG--CgRQGPFKLLPEK--SEFIDAQKIRIQEPPEDL--PGGQQPQSIDVILEDDLVGEVR 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 318 PGDTVTITGIVKVsntEEGSRNKNDKCMFLLYIEANSVSNSkgQKAQtaEDgcqhgtlMEFSLKDLYAIQEIQAEENLLK 397
Cdd:COG1241 209 PGDRVTVTGILRI---EQRTSGRGKSTIFDLYLEANSIEVE--EKEF--EE-------IEITEEDEEKIKELSKDPDIYE 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 398 LIVNSLCPVIFGHELVKAGLVLALFGGSQKYADDKNRIpiRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 477
Cdd:COG1241 275 KIIASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRI--RGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTA 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 478 SGLTVTLSKDS-SSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANP 555
Cdd:COG1241 353 AGLTAAAVRDDfGTGRWTLEAGALVLADGGLACIDELDKMREEDRsALHEAMEQQTISIAKAGIVATLNARCSVLAAANP 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 556 VGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQRavssatvaralsqdsNTSVLEVVS 635
Cdd:COG1241 433 KYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVHRAGEL---------------LEQEIEEET 497
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 636 EkplserlkvapgETTDPIPHQLLRKYVGYARQYVHPKLSTEAAQALQDFYLELRKQSQRMSSS-PITTRQLESLIRLTE 714
Cdd:COG1241 498 E------------EVKPEIDPDLLRKYIAYARRNVFPVLTEEAKDLIEDFYVDMRKKGEDEDSPvPITARQLEALIRLAE 565
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 715 ARARLELREEATKEDAEDIIEIMKHSMLGTYSD-EFGNLDFERSQHGSGMSNRSTAKRFISALNSIAERT 783
Cdd:COG1241 566 ASARMRLSDTVTEEDAERAIRLVDSCLKDVGVDpETGKFDIDVIETGTSKSQRDKMKLIKDIIKELEEES 635
|
|
| MCM8 |
cd17759 |
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ... |
398-740 |
0e+00 |
|
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350665 [Multi-domain] Cd Length: 289 Bit Score: 544.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 398 LIVNSLCPVIFGHELVKAGLVLALFGGSQKYADDKNRIPIRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 477
Cdd:cd17759 1 LIVNSLCPAIYGHELVKAGLLLSLFGGKQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 478 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVG 557
Cdd:cd17759 81 SGLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGSQHQALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 558 GHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHviairagkqravssatvaralsqdsntsvlevvsek 637
Cdd:cd17759 161 GHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDHLLSEH------------------------------------ 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 638 plserlkvapgettdpipHQLLRKYVGYARQYVHPKLSTEAAQALQDFYLELRKQSQRMSSSPITTRQLESLIRLTEARA 717
Cdd:cd17759 205 ------------------HQLLRKYISYARQYVNPVLSKDASEALQEFYLELRKQNQLADSSPITTRQLESLIRLTEARA 266
|
330 340
....*....|....*....|...
gi 1538017668 718 RLELREEATKEDAEDIIEIMKHS 740
Cdd:cd17759 267 RLELREEATKEDAEDVIEIMKES 289
|
|
| MCM |
smart00350 |
minichromosome maintenance proteins; |
200-742 |
2.79e-156 |
|
minichromosome maintenance proteins;
Pssm-ID: 214631 [Multi-domain] Cd Length: 509 Bit Score: 471.36 E-value: 2.79e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 200 LKNVRANCYGKYISIRGTVVRVGNIKPLCTKMAFRCAACGEIQSFPLPDGKYNLPTKCPVPACRGKSFTPLRSSpLTVTV 279
Cdd:smart00350 5 IRELRADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGPEIQSGRETEPTVCPPRECQSPTPFSLNHE-RSTFI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 280 DWQLIKIQELMSDAQreAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNTEEGSRNKNDKCMFLLYIEANSVSNSK 359
Cdd:smart00350 84 DFQKIKLQESPEEVP--VGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVPYGFKLNTVKGLPVFATYIEANHVRKLD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 360 GQKAQTAEdgcqHGTLMEFSLKDLYAIQEIQAEENLLKLIVNSLCPVIFGHELVKAGLVLALFGGSQKYADDKNRIpiRG 439
Cdd:smart00350 162 YKRSFEDS----SFSVQSLSDEEEEEIRKLSKDPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMKI--RG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 440 DPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQ 519
Cdd:smart00350 236 DINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDS 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 520 HQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLL 598
Cdd:smart00350 316 DRtAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDREL 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 599 SEHVIAIRagkqravssatVARALSQDSNTSVlevvsekplserlkvapgettdPIPHQLLRKYVGYARQYVHPKLSTEA 678
Cdd:smart00350 396 AKHVVDLH-----------RYSHPEEDEAFEP----------------------PLSQEKLRKYIAYAREKIKPKLSEEA 442
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1538017668 679 AQALQDFYLELRK---QSQRMSSSPITTRQLESLIRLTEARARLELREEATKEDAEDIIEIMKHSML 742
Cdd:smart00350 443 ADKLVKAYVDLRKedsQTESRSSIPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAIRLLRESII 509
|
|
| MCM |
pfam00493 |
MCM P-loop domain; |
382-606 |
2.78e-113 |
|
MCM P-loop domain;
Pssm-ID: 459830 [Multi-domain] Cd Length: 224 Bit Score: 348.37 E-value: 2.78e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 382 DLYAIQEIQAEENLLKLIVNSLCPVIFGHELVKAGLVLALFGGSQKYADDKNRIpiRGDPHILIVGDPGLGKSQMLQAAC 461
Cdd:pfam00493 1 DEEEIKELAKRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRL--RGDINVLLVGDPGTAKSQLLKYVE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 462 NVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQ-HQALLEAMEQQSISLAKAGVV 540
Cdd:pfam00493 79 KIAPRAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEdRVALHEAMEQQTISIAKAGIV 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1538017668 541 CSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIR 606
Cdd:pfam00493 159 ATLNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
|
|
| PTZ00111 |
PTZ00111 |
DNA replication licensing factor MCM4; Provisional |
63-760 |
1.21e-85 |
|
DNA replication licensing factor MCM4; Provisional
Pssm-ID: 173403 [Multi-domain] Cd Length: 915 Bit Score: 295.75 E-value: 1.21e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 63 DQFIP-----YKGWKL--YFSEVYSNSSPFIEKIQAFEKFFTrHIDFYDKDEIErkgsILVDFkeltkddeitnlipdie 135
Cdd:PTZ00111 112 QQSKPeytelYYLWKLmnFIKENLRDHSTGYSRILPFEVDLM-HVYSFDKVLYK----LLVTF----------------- 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 136 ntlrdtPEKTLACMGLAIHQVLTKDLEQHAAELQAQEglssdgetmvNVPHIFARVYNYEPLTHLKNVRANCYGKYISIR 215
Cdd:PTZ00111 170 ------PADCIAELDKVLVKLFNELLSKHYSDLSLEN----------NSFFPRARLMNKPVSDCVGNLEPSMADSLVQFS 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 216 GTVVRVGNIKPLCTKMAFRCAA-----------CGEIQSFPLPDGKYNLPTKCPvpACRGKSFTPLRSSpLTVTVDWQLI 284
Cdd:PTZ00111 234 GTVVRQTWIVPEITMACFRCRGqkkiglndyqpCTCEHYEYVIQGEVNEPLLCN--ECNSKYTFELNHN-MCVYSTKKIV 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 285 KIQELMS--------------DAQREAGRI----PRTIECELVHDLVDSCVPGDTVTITGIVKVSNTEEGSRNKNDKCMF 346
Cdd:PTZ00111 311 KLLQSNSslnnpdkdgldnsvDNSGLNGEIymkdNEVINLNLYDDLIDSVKTGDRVTVVGILKVTPIRTSTTRRTLKSLY 390
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 347 LLYIEANSVSNSKGQKAQTAEDGCQH-GTLMEFSLKDLYAIQEIQAEENLLKLIVNSLCPVIFGHELVKAGLVLALFGGS 425
Cdd:PTZ00111 391 TYFVNVIHVKVINSTNANQPEKGLKYlGNENDFSDLQVYKILELSRNPMIYRILLDSFAPSIKARNNVKIGLLCQLFSGN 470
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 426 qKYADDKNRIP--------IRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLS-KDSSSGDFALE 496
Cdd:PTZ00111 471 -KNSSDFNKSPdacykvdnFRGIINVLLCGDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASIKfNESDNGRAMIQ 549
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 497 AGALVLGDQGICGIDEFDKMGNQHQALL-EAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSA 575
Cdd:PTZ00111 550 PGAVVLANGGVCCIDELDKCHNESRLSLyEVMEQQTVTIAKAGIVATLKAETAILASCNPINSRYNKNKAVIENINISPS 629
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 576 LLSRFDLVFILLDTPNEQHDHLLSEhVIAiragKQRAVSSATVARALS---QDSNTSVLEvvsekplSERLKvaPGETTD 652
Cdd:PTZ00111 630 LFTRFDLIYLVLDHIDQDTDQLISL-SIA----KDFLLPHMTGSGNDEdtyDRSNTMHVE-------DESLR--SEKDYN 695
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 653 PIPHQLLRKYVGYARQYVHPKLSTEAAQALQDFYLELRK------------------------QSQRMSSSPITTRQLES 708
Cdd:PTZ00111 696 KNDLDMLRMYIKFSKLHCFPKLSDEAKKVITREYVKMRQgnfqtsnldelehaqedddddlyyQSSGTRMIYVSSRMISS 775
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|...
gi 1538017668 709 LIRLTEARARLELREEATKEDAEDIIEIMKHSMLGTYSDEF-GNLDFERSQHG 760
Cdd:PTZ00111 776 IIRISVSLARMRLSTVVTPADALQAVQIVKSSTFQSLVDPTtGKIDFDQLHQG 828
|
|
| PgsA |
COG0558 |
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ... |
805-1003 |
2.94e-35 |
|
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis
Pssm-ID: 440324 [Multi-domain] Cd Length: 177 Bit Score: 132.29 E-value: 2.94e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 805 ENPWTIPNMLSMTRIGLAPVLGYLILEEDFN-VALGVFALAGLTDLLDGFIARNWaNQKSALGSALDPLADKVLISILYV 883
Cdd:COG0558 6 RRLLNIPNQLTLLRILLVPVFALLLLLGGALlLALVLFLLAGLTDALDGYLARRL-GQVSRFGAFLDPVADKLLDAAALL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 884 SLTYADLIPVPLTYMIISRDVIliaaVFYVRYRtlptprtlakyfnpcYATARLKPTFISKVNTAVQLILVAASLAAPVF 963
Cdd:COG0558 85 GLVLLGLLPAWLALLILLRELL----VSYLRAR---------------AAALGVVASYLGKAKTVLQLVAILLLLLGLPL 145
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1538017668 964 NYAdsiylqILWCCTAFTtaasAYSYYHYGRKTVQVIKGK 1003
Cdd:COG0558 146 LGV------LLWLAAVLT----LLSGIQYLVAARRALRAR 175
|
|
| PLN02794 |
PLN02794 |
cardiolipin synthase |
810-1001 |
9.51e-32 |
|
cardiolipin synthase
Pssm-ID: 178391 Cd Length: 341 Bit Score: 127.27 E-value: 9.51e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 810 IPNMLSMTRIGLAPVLGYLILEEDFNVALGVFALAGLTDLLDGFIARNwANQKSALGSALDPLADKVLISILYVSLTYAD 889
Cdd:PLN02794 144 LPNLISISRLVSGPVIGWMIVNEMYLSAFVGLAISGASDWLDGYVARK-MGINSVVGSYLDPLADKVLIGCVALAMVEKD 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 890 LIPVPLTYMIISRDVILIAAVFYVRYRTLPTP-RTLAKYFN-PCYATARLKPTFISKVNTAVQLILVAASLAAPVFNYAD 967
Cdd:PLN02794 223 LLHPGLVGLVVLRDVALVGGAVYKRASSLGWKwNSWSDFFNlDGTRPEKVEPLFISKVNTVFQLMLVAAALLQPEFGTEE 302
|
170 180 190
....*....|....*....|....*....|....*..
gi 1538017668 968 SI-YLQILWCCTAFTTAAS--AYSYYHYGRKTVQVIK 1001
Cdd:PLN02794 303 TQnYITYLSWLVASTTVAStaAYGVQYMKNRPRLLAK 339
|
|
| CDP-OH_P_transf |
pfam01066 |
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ... |
808-981 |
1.82e-30 |
|
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.
Pssm-ID: 460049 [Multi-domain] Cd Length: 157 Bit Score: 117.66 E-value: 1.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 808 WTIPNMLSMTRIGLAPVLGYLILE-EDFNVALGVFALAGLTDLLDGFIARnWANQKSALGSALDPLADKVLISILYVSLT 886
Cdd:pfam01066 1 LNLPNLLTLLRILLVPVFVVLLLGpGNRILAAVVFALAALTDFLDGKIAR-KLNQVTDFGKFLDPLADKLLVAAALIALS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 887 YADLIPVPLTYMIISRDVILIAAVFYVRYRTLPTPrtlAKYFnpcyatarlkptfiSKVNTAVQLILVAASLAAPVFNYA 966
Cdd:pfam01066 80 ILGLLPWWFVVVILVRELGVTLLRFNVARKGVVIP---ASRG--------------GKIKTALQMVAIGLLLLPLPGLLP 142
|
170
....*....|....*
gi 1538017668 967 dsIYLQILWCCTAFT 981
Cdd:pfam01066 143 --LAGILLWLALALT 155
|
|
| pgsA |
TIGR00560 |
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ... |
810-981 |
3.20e-20 |
|
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]
Pssm-ID: 273139 [Multi-domain] Cd Length: 182 Bit Score: 89.33 E-value: 3.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 810 IPNMLSMTRIGLAPVLGYLILEEDFNVAL------GVFALAGLTDLLDGFIARNWaNQKSALGSALDPLADKVLISILYV 883
Cdd:TIGR00560 3 IPNWLTLFRIIALPIFILFFLENVLPIQVspfigaLLFIFAAVTDWLDGYLARKW-NQVSNFGKFLDPLADKVLVLAVLI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 884 SLTYADLIPVPLTYMIISRDvILIAAVfyvryrtlptpRTLAKYFNPCYATarlkpTFISKVNTAVQLILVAASLAAPV- 962
Cdd:TIGR00560 82 ILVYHGYVPAWFVIVIIARE-IVISGL-----------RVLAAEKKVVIAA-----NWLGKWKTTAQMVAIGALLLWRLt 144
|
170 180
....*....|....*....|
gi 1538017668 963 -FNYADSIYLQILWCCTAFT 981
Cdd:TIGR00560 145 fKIFFEFIVQLLYYIAAFFT 164
|
|
| MCM8_WHD |
cd22247 |
winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; ... |
766-806 |
2.99e-12 |
|
winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; MCM8 is a DNA helicase that is a component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is also required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting its nuclease activity. This model corresponds to the C-terminal winged-helix domain (WHD) of MCM8, which mediates protein-nucleic acid interaction, as well as protein-protein interaction.
Pssm-ID: 439328 [Multi-domain] Cd Length: 66 Bit Score: 62.50 E-value: 2.99e-12
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1538017668 766 RSTAKRFISALNSIAERTYNNIFQFHQLRQIAKELNIQYEN 806
Cdd:cd22247 1 RKQAKRFVSALQREAERKGNNLFTVDELKQIAKELGLQVDD 41
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Mcm2 |
COG1241 |
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ... |
86-783 |
0e+00 |
|
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];
Pssm-ID: 440854 [Multi-domain] Cd Length: 682 Bit Score: 564.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 86 IEKIQAFEKFFTRHIdfYdKDEI-------ERKGSILVDFKELTKDDeitnliPDIENTLRDTPEKTLACMGLAIHQVLT 158
Cdd:COG1241 3 SDLVDKFEEFLRRYK--Y-RDEIlelaqeyPEKRSLVVDYNDLYSFD------PDLADDLLENPDEVLEAAEEALREIDL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 159 KDLEqhaaelqaqeglssdgetmVNVPHIFARVYNYEPLTHLKNVRANCYGKYISIRGTVVRVGNIKPLCTKMAFRCAAC 238
Cdd:COG1241 74 EPYD-------------------VSLGDAHVRITNLPETVPIRDIRSDHIGKLISVEGIVRKATEVKPKITEAAFECPRC 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 239 GEIQSFPLPDGKYNLPTKCPVpaC-RGKSFTPLRSSplTVTVDWQLIKIQELMSDAqrEAGRIPRTIECELVHDLVDSCV 317
Cdd:COG1241 135 GTETYVPQTGEKLQEPHECPG--CgRQGPFKLLPEK--SEFIDAQKIRIQEPPEDL--PGGQQPQSIDVILEDDLVGEVR 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 318 PGDTVTITGIVKVsntEEGSRNKNDKCMFLLYIEANSVSNSkgQKAQtaEDgcqhgtlMEFSLKDLYAIQEIQAEENLLK 397
Cdd:COG1241 209 PGDRVTVTGILRI---EQRTSGRGKSTIFDLYLEANSIEVE--EKEF--EE-------IEITEEDEEKIKELSKDPDIYE 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 398 LIVNSLCPVIFGHELVKAGLVLALFGGSQKYADDKNRIpiRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 477
Cdd:COG1241 275 KIIASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRI--RGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTA 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 478 SGLTVTLSKDS-SSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANP 555
Cdd:COG1241 353 AGLTAAAVRDDfGTGRWTLEAGALVLADGGLACIDELDKMREEDRsALHEAMEQQTISIAKAGIVATLNARCSVLAAANP 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 556 VGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQRavssatvaralsqdsNTSVLEVVS 635
Cdd:COG1241 433 KYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVHRAGEL---------------LEQEIEEET 497
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 636 EkplserlkvapgETTDPIPHQLLRKYVGYARQYVHPKLSTEAAQALQDFYLELRKQSQRMSSS-PITTRQLESLIRLTE 714
Cdd:COG1241 498 E------------EVKPEIDPDLLRKYIAYARRNVFPVLTEEAKDLIEDFYVDMRKKGEDEDSPvPITARQLEALIRLAE 565
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 715 ARARLELREEATKEDAEDIIEIMKHSMLGTYSD-EFGNLDFERSQHGSGMSNRSTAKRFISALNSIAERT 783
Cdd:COG1241 566 ASARMRLSDTVTEEDAERAIRLVDSCLKDVGVDpETGKFDIDVIETGTSKSQRDKMKLIKDIIKELEEES 635
|
|
| MCM8 |
cd17759 |
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ... |
398-740 |
0e+00 |
|
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350665 [Multi-domain] Cd Length: 289 Bit Score: 544.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 398 LIVNSLCPVIFGHELVKAGLVLALFGGSQKYADDKNRIPIRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 477
Cdd:cd17759 1 LIVNSLCPAIYGHELVKAGLLLSLFGGKQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 478 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVG 557
Cdd:cd17759 81 SGLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGSQHQALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 558 GHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHviairagkqravssatvaralsqdsntsvlevvsek 637
Cdd:cd17759 161 GHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDHLLSEH------------------------------------ 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 638 plserlkvapgettdpipHQLLRKYVGYARQYVHPKLSTEAAQALQDFYLELRKQSQRMSSSPITTRQLESLIRLTEARA 717
Cdd:cd17759 205 ------------------HQLLRKYISYARQYVNPVLSKDASEALQEFYLELRKQNQLADSSPITTRQLESLIRLTEARA 266
|
330 340
....*....|....*....|...
gi 1538017668 718 RLELREEATKEDAEDIIEIMKHS 740
Cdd:cd17759 267 RLELREEATKEDAEDVIEIMKES 289
|
|
| MCM |
smart00350 |
minichromosome maintenance proteins; |
200-742 |
2.79e-156 |
|
minichromosome maintenance proteins;
Pssm-ID: 214631 [Multi-domain] Cd Length: 509 Bit Score: 471.36 E-value: 2.79e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 200 LKNVRANCYGKYISIRGTVVRVGNIKPLCTKMAFRCAACGEIQSFPLPDGKYNLPTKCPVPACRGKSFTPLRSSpLTVTV 279
Cdd:smart00350 5 IRELRADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGPEIQSGRETEPTVCPPRECQSPTPFSLNHE-RSTFI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 280 DWQLIKIQELMSDAQreAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNTEEGSRNKNDKCMFLLYIEANSVSNSK 359
Cdd:smart00350 84 DFQKIKLQESPEEVP--VGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVPYGFKLNTVKGLPVFATYIEANHVRKLD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 360 GQKAQTAEdgcqHGTLMEFSLKDLYAIQEIQAEENLLKLIVNSLCPVIFGHELVKAGLVLALFGGSQKYADDKNRIpiRG 439
Cdd:smart00350 162 YKRSFEDS----SFSVQSLSDEEEEEIRKLSKDPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMKI--RG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 440 DPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQ 519
Cdd:smart00350 236 DINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDS 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 520 HQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLL 598
Cdd:smart00350 316 DRtAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDREL 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 599 SEHVIAIRagkqravssatVARALSQDSNTSVlevvsekplserlkvapgettdPIPHQLLRKYVGYARQYVHPKLSTEA 678
Cdd:smart00350 396 AKHVVDLH-----------RYSHPEEDEAFEP----------------------PLSQEKLRKYIAYAREKIKPKLSEEA 442
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1538017668 679 AQALQDFYLELRK---QSQRMSSSPITTRQLESLIRLTEARARLELREEATKEDAEDIIEIMKHSML 742
Cdd:smart00350 443 ADKLVKAYVDLRKedsQTESRSSIPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAIRLLRESII 509
|
|
| MCM |
cd17706 |
MCM helicase family; MCM helicases are a family of helicases that play an important role in ... |
398-740 |
3.68e-155 |
|
MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350658 [Multi-domain] Cd Length: 311 Bit Score: 460.66 E-value: 3.68e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 398 LIVNSLCPVIFGHELVKAGLVLALFGGSQKYADDknRIPIRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 477
Cdd:cd17706 1 ILADSIAPSIYGHEDVKKAVLLQLFGGVQKILED--GTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 478 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPV 556
Cdd:cd17706 79 AGLTAAVVRDSETGEWYLEAGALVLADGGVCCIDEFDKMKELDRtALHEAMEQQTISIAKAGIVTTLNARCSILAAANPK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 557 GGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQRAVssatvaralsqdsntsvlevvse 636
Cdd:cd17706 159 GGRYNPKLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIDLHRGSDPEE----------------------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 637 kplserlKVAPGETTDPIPHQLLRKYVGYARQyVHPKLSTEAAQALQDFYLELRKQSQRMSSSPITTRQLESLIRLTEAR 716
Cdd:cd17706 216 -------QVKPEEDGIPIDIELLRKYILYARQ-IHPKISEEAREKLVRWYVELRKESERRSTIPITARQLESVIRLAEAH 287
|
330 340
....*....|....*....|....
gi 1538017668 717 ARLELREEATKEDAEDIIEIMKHS 740
Cdd:cd17706 288 AKMRLSEVVTEEDVEEAIRLVRHS 311
|
|
| MCM_arch |
cd17761 |
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ... |
398-737 |
5.82e-114 |
|
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork
Pssm-ID: 350667 [Multi-domain] Cd Length: 308 Bit Score: 353.29 E-value: 5.82e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 398 LIVNSLCPVIFGHELVKAGLVLALFGGSQKYADDKNRIpiRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 477
Cdd:cd17761 2 KIISSIAPSIYGHEDVKEAIALQLFGGVPKVLPDGTRI--RGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 478 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPV 556
Cdd:cd17761 80 AGLTAAVVRDEGTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRsALHEAMEQQTISIAKAGIVATLNARAAVLAAANPK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 557 GGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQravssatvaralsqdsntsvlevvse 636
Cdd:cd17761 160 FGRFDSYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILDTHSGGE-------------------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 637 kplserlkvaPGETTDPIPHQLLRKYVGYARQYVHPKLSTEAAQALQDFYLELRKQSQRMSSS-PITTRQLESLIRLTEA 715
Cdd:cd17761 214 ----------MREIKPEIDPDLLRKYIAYARKNVRPVLTEEAKQLIKDFYVEMRKSGQETPSPvPITARQLEALVRLSEA 283
|
330 340
....*....|....*....|..
gi 1538017668 716 RARLELREEATKEDAEDIIEIM 737
Cdd:cd17761 284 SARMRLSQEVTLEDAERAIRIM 305
|
|
| MCM |
pfam00493 |
MCM P-loop domain; |
382-606 |
2.78e-113 |
|
MCM P-loop domain;
Pssm-ID: 459830 [Multi-domain] Cd Length: 224 Bit Score: 348.37 E-value: 2.78e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 382 DLYAIQEIQAEENLLKLIVNSLCPVIFGHELVKAGLVLALFGGSQKYADDKNRIpiRGDPHILIVGDPGLGKSQMLQAAC 461
Cdd:pfam00493 1 DEEEIKELAKRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRL--RGDINVLLVGDPGTAKSQLLKYVE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 462 NVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQ-HQALLEAMEQQSISLAKAGVV 540
Cdd:pfam00493 79 KIAPRAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEdRVALHEAMEQQTISIAKAGIV 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1538017668 541 CSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIR 606
Cdd:pfam00493 159 ATLNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
|
|
| MCM2 |
cd17753 |
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ... |
399-740 |
3.17e-104 |
|
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350659 [Multi-domain] Cd Length: 325 Bit Score: 328.25 E-value: 3.17e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 399 IVNSLCPVIFGHELVKAGLVLALFGGSQKYADDKNRIpiRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSS 478
Cdd:cd17753 2 IINSIAPSIYGHDDIKTAIALALFGGVAKNPGGKHRI--RGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 479 GLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVG 557
Cdd:cd17753 80 GLTASVRKDPVTKEWTLEGGALVLADKGVCLIDEFDKMNDQDRtSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 558 GHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQRavssatvaralSQDSNTSVLEVVSEK 637
Cdd:cd17753 160 GRYNPTLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFVVGSHVRSHP-----------ENDEDREGEEEKNQR 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 638 PLSERLKVapgettDPIPHQLLRKYVGYARQYVHPKLSTEAAQALQDFYLELRKQSQRMSSSPITTRQLESLIRLTEARA 717
Cdd:cd17753 229 QRPKETKV------EPIPQELLRKYIHYAREKVRPKLNQMDMDKVSRVYADLRKESMATGSLPITVRHLESIIRISEAHA 302
|
330 340
....*....|....*....|...
gi 1538017668 718 RLELREEATKEDAEDIIEIMKHS 740
Cdd:cd17753 303 KMHLREYVSEEDVDMAIRVMLDS 325
|
|
| MCM6 |
cd17757 |
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ... |
399-740 |
8.18e-103 |
|
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350663 [Multi-domain] Cd Length: 307 Bit Score: 323.94 E-value: 8.18e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 399 IVNSLCPVIFGHELVKAGLVLALFGGSQKYADDKnrIPIRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSS 478
Cdd:cd17757 2 LVRSIAPSIYGHEEVKKGILLMLLGGVHKITREG--ISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 479 GLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVG 557
Cdd:cd17757 80 GLTAAVVRDEETGDFVIEAGALMLADNGICCIDEFDKMDIKDQvAIHEAMEQQTISITKAGIQATLNARTSILAAANPVG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 558 GHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQRAVSSatvaralsqdsntsvlevvsek 637
Cdd:cd17757 160 GRYDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHIVDLHSKREEAIEP---------------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 638 plserlkvapgettdPIPHQLLRKYVGYARQyVHPKLSTEAAQALQDFYLELRKQSQRMSSSP---ITTRQLESLIRLTE 714
Cdd:cd17757 218 ---------------PFTAEQLKRYIAYART-FKPKLTKEAKDELVEQYKELRQDDASGSTRSsyrITVRQLESLIRLSE 281
|
330 340
....*....|....*....|....*.
gi 1538017668 715 ARARLELREEATKEDAEDIIEIMKHS 740
Cdd:cd17757 282 AIARLHCSDEVTPEHVEEAARLLKKS 307
|
|
| MCM4 |
cd17755 |
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ... |
398-738 |
4.70e-100 |
|
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350661 [Multi-domain] Cd Length: 309 Bit Score: 316.69 E-value: 4.70e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 398 LIVNSLCPVIFGHELVKAGLVLALFGGSQKyADDKNRIPIRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 477
Cdd:cd17755 1 RLARSIAPSIYELEDVKKGILLQLFGGTRK-DFTKTGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 478 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALL-EAMEQQSISLAKAGVVCSLPARTSIIAAANPV 556
Cdd:cd17755 80 VGLTAYVTRDPDTKQLVLESGALVLSDGGICCIDEFDKMSDSTRSVLhEVMEQQTLSIAKAGIITTLNARTSILASANPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 557 GGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIragkqravssatvaralsqdsntsvleVVSE 636
Cdd:cd17755 160 GSRYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLVSL---------------------------YLED 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 637 KPLSerlkvapgETTDPIPHQLLRKYVGYARQYVHPKLSTEAAQALQDFYLELRK-QSQRMSSSPITTRQLESLIRLTEA 715
Cdd:cd17755 213 TPEH--------IQDEVLDVEVLTDYISYAREHIHPKLSEEAAQELVQAYVDMRKmGSDARKRITATPRQLESLIRLAEA 284
|
330 340
....*....|....*....|...
gi 1538017668 716 RARLELREEATKEDAEDIIEIMK 738
Cdd:cd17755 285 HAKMRLSNVVEAEDVEEAVRLIR 307
|
|
| MCM5 |
cd17756 |
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ... |
398-740 |
6.19e-99 |
|
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350662 [Multi-domain] Cd Length: 317 Bit Score: 313.94 E-value: 6.19e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 398 LIVNSLCPVIFGHELVKAGLVLALFGGSQKYADDKNRIpiRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 477
Cdd:cd17756 1 IISKSIAPSIYGNEDIKKAIACLLFGGSRKRLPDGMRL--RGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 478 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMgNQHQ--ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANP 555
Cdd:cd17756 79 AGLTASVMRDPSTREFYLEGGAMVLADGGVVCIDEFDKM-REDDrvAIHEAMEQQTISIAKAGITTTLNSRTSVLAAANP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 556 VGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQRAVSSatvaralsqdsntsvlevvs 635
Cdd:cd17756 158 VFGRYDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVINIHASARKASQS-------------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 636 ekplserlkvapGETTDPIPHQLLRKYVGYARQYVHPKLSTEAAQALQDFYLELRKQ-------SQRMSSSPITTRQLES 708
Cdd:cd17756 218 ------------QENEGEIPISKLKRYIAYCRAKCAPRLSEEAAEKLSNHYVTIRKDvrqneleSDNRSSIPITVRQLEA 285
|
330 340 350
....*....|....*....|....*....|..
gi 1538017668 709 LIRLTEARARLELREEATKEDAEDIIEIMKHS 740
Cdd:cd17756 286 IIRISESLAKMELSPIATEKHVEEAIRLFQVS 317
|
|
| MCM7 |
cd17758 |
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ... |
402-740 |
9.93e-92 |
|
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350664 [Multi-domain] Cd Length: 306 Bit Score: 294.32 E-value: 9.93e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 402 SLCPVIFGHELVKAGLVLALFGGSQKYADDknrIPIRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLT 481
Cdd:cd17758 5 SIAPEIYGHEDVKKALLLLLVGGVDKRGDG---MKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 482 VTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHY 560
Cdd:cd17758 82 AAVMKDPVTGEMTLEGGALVLADQGICCIDEFDKMDESDRtAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAYGRY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 561 NKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHViairagkqravssatvaralsqdsnTSVLEVVsekpls 640
Cdd:cd17758 162 NPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHV-------------------------TYVHQHN------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 641 erlkVAPGETTDPIPHQLLRKYVGYARQYvHPKLSTEAAQALQDFYLELRKQSQRMSSSPITT-RQLESLIRLTEARARL 719
Cdd:cd17758 211 ----KQPDSDFEPLDPKLLRAYIALAKRK-RPTVPPALADYIVQAYVEMRQEAKRSKDFTFTTpRTLLAILRLSQALARL 285
|
330 340
....*....|....*....|.
gi 1538017668 720 ELREEATKEDAEDIIEIMKHS 740
Cdd:cd17758 286 RLSDSVEIDDVEEALRLMEMS 306
|
|
| MCM9 |
cd17760 |
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ... |
398-740 |
6.94e-87 |
|
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350666 [Multi-domain] Cd Length: 299 Bit Score: 280.97 E-value: 6.94e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 398 LIVNSLCPVIFGHELVKAGLVLALFGGSQKYADDKNRIpiRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 477
Cdd:cd17760 1 EILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRV--RGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 478 SGLTVTLSKDssSGDFALEAGALVLGDQGICGIDEFDKMG-NQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPv 556
Cdd:cd17760 79 AGLTVTAVKD--GGEWNLEAGALVLADGGLCCIDEFNSLKeHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 557 GGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIairaGKQRAVSSATVAralsqdsntsvlevvse 636
Cdd:cd17760 156 KGQYDPNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFIL----ENKGEPSKSSKL----------------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 637 kplserlkvapgettdpIPHQLLRKYVGYARQyVHPKLSTEAAQALQDFYlELRKQSQRMSSSPITTRQLESLIRLTEAR 716
Cdd:cd17760 215 -----------------WSMEKMRTYFCLIKN-LRPVLSDEANAILLRYY-QLQRQSDCRNAARTTIRMLESLIRLAEAH 275
|
330 340
....*....|....*....|....
gi 1538017668 717 ARLELREEATKEDAEDIIEIMKHS 740
Cdd:cd17760 276 ARLMFRETVTEEDAITVVSVMESS 299
|
|
| PTZ00111 |
PTZ00111 |
DNA replication licensing factor MCM4; Provisional |
63-760 |
1.21e-85 |
|
DNA replication licensing factor MCM4; Provisional
Pssm-ID: 173403 [Multi-domain] Cd Length: 915 Bit Score: 295.75 E-value: 1.21e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 63 DQFIP-----YKGWKL--YFSEVYSNSSPFIEKIQAFEKFFTrHIDFYDKDEIErkgsILVDFkeltkddeitnlipdie 135
Cdd:PTZ00111 112 QQSKPeytelYYLWKLmnFIKENLRDHSTGYSRILPFEVDLM-HVYSFDKVLYK----LLVTF----------------- 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 136 ntlrdtPEKTLACMGLAIHQVLTKDLEQHAAELQAQEglssdgetmvNVPHIFARVYNYEPLTHLKNVRANCYGKYISIR 215
Cdd:PTZ00111 170 ------PADCIAELDKVLVKLFNELLSKHYSDLSLEN----------NSFFPRARLMNKPVSDCVGNLEPSMADSLVQFS 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 216 GTVVRVGNIKPLCTKMAFRCAA-----------CGEIQSFPLPDGKYNLPTKCPvpACRGKSFTPLRSSpLTVTVDWQLI 284
Cdd:PTZ00111 234 GTVVRQTWIVPEITMACFRCRGqkkiglndyqpCTCEHYEYVIQGEVNEPLLCN--ECNSKYTFELNHN-MCVYSTKKIV 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 285 KIQELMS--------------DAQREAGRI----PRTIECELVHDLVDSCVPGDTVTITGIVKVSNTEEGSRNKNDKCMF 346
Cdd:PTZ00111 311 KLLQSNSslnnpdkdgldnsvDNSGLNGEIymkdNEVINLNLYDDLIDSVKTGDRVTVVGILKVTPIRTSTTRRTLKSLY 390
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 347 LLYIEANSVSNSKGQKAQTAEDGCQH-GTLMEFSLKDLYAIQEIQAEENLLKLIVNSLCPVIFGHELVKAGLVLALFGGS 425
Cdd:PTZ00111 391 TYFVNVIHVKVINSTNANQPEKGLKYlGNENDFSDLQVYKILELSRNPMIYRILLDSFAPSIKARNNVKIGLLCQLFSGN 470
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 426 qKYADDKNRIP--------IRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLS-KDSSSGDFALE 496
Cdd:PTZ00111 471 -KNSSDFNKSPdacykvdnFRGIINVLLCGDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASIKfNESDNGRAMIQ 549
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 497 AGALVLGDQGICGIDEFDKMGNQHQALL-EAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSA 575
Cdd:PTZ00111 550 PGAVVLANGGVCCIDELDKCHNESRLSLyEVMEQQTVTIAKAGIVATLKAETAILASCNPINSRYNKNKAVIENINISPS 629
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 576 LLSRFDLVFILLDTPNEQHDHLLSEhVIAiragKQRAVSSATVARALS---QDSNTSVLEvvsekplSERLKvaPGETTD 652
Cdd:PTZ00111 630 LFTRFDLIYLVLDHIDQDTDQLISL-SIA----KDFLLPHMTGSGNDEdtyDRSNTMHVE-------DESLR--SEKDYN 695
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 653 PIPHQLLRKYVGYARQYVHPKLSTEAAQALQDFYLELRK------------------------QSQRMSSSPITTRQLES 708
Cdd:PTZ00111 696 KNDLDMLRMYIKFSKLHCFPKLSDEAKKVITREYVKMRQgnfqtsnldelehaqedddddlyyQSSGTRMIYVSSRMISS 775
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|...
gi 1538017668 709 LIRLTEARARLELREEATKEDAEDIIEIMKHSMLGTYSDEF-GNLDFERSQHG 760
Cdd:PTZ00111 776 IIRISVSLARMRLSTVVTPADALQAVQIVKSSTFQSLVDPTtGKIDFDQLHQG 828
|
|
| MCM3 |
cd17754 |
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ... |
398-738 |
4.91e-80 |
|
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350660 [Multi-domain] Cd Length: 299 Bit Score: 262.79 E-value: 4.91e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 398 LIVNSLCPVIFGHELVKAGLVLALFGGSQKyaDDKNRIPIRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 477
Cdd:cd17754 1 LLSKSLAPSIYGHEYIKKAILLMLLGGVEK--NLENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 478 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPV 556
Cdd:cd17754 79 VGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRvAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 557 GGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIragkQRAVssatvaralsqdsntsvlevvse 636
Cdd:cd17754 159 YGRYDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRM----HRYI----------------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 637 kplserlkvapgettdpiphQLLRKYVGYARQYVHPKLSTEAAQALQDFYLELRKQ----SQRMSSSPITTRQLESLIRL 712
Cdd:cd17754 212 --------------------KFLRKYIHYAKERIKPKLTQEAAEYIAEEYADLRNDdntkTDKARTSPITARTLETLIRL 271
|
330 340
....*....|....*....|....*.
gi 1538017668 713 TEARARLELREEATKEDAEDIIEIMK 738
Cdd:cd17754 272 ATAHAKARLSKTVDKVDAEVALNLLR 297
|
|
| MCM_lid |
pfam17855 |
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins. |
657-741 |
1.70e-35 |
|
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
Pssm-ID: 465534 [Multi-domain] Cd Length: 86 Bit Score: 129.59 E-value: 1.70e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 657 QLLRKYVGYARQYVHPKLSTEAAQALQDFYLELRKQSQRMSSS-PITTRQLESLIRLTEARARLELREEATKEDAEDIIE 735
Cdd:pfam17855 1 ELLRKYIAYAREKIKPKLSEEAREKLVDAYVELRKESTGSGSSiPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIR 80
|
....*.
gi 1538017668 736 IMKHSM 741
Cdd:pfam17855 81 LLKESL 86
|
|
| PgsA |
COG0558 |
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ... |
805-1003 |
2.94e-35 |
|
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis
Pssm-ID: 440324 [Multi-domain] Cd Length: 177 Bit Score: 132.29 E-value: 2.94e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 805 ENPWTIPNMLSMTRIGLAPVLGYLILEEDFN-VALGVFALAGLTDLLDGFIARNWaNQKSALGSALDPLADKVLISILYV 883
Cdd:COG0558 6 RRLLNIPNQLTLLRILLVPVFALLLLLGGALlLALVLFLLAGLTDALDGYLARRL-GQVSRFGAFLDPVADKLLDAAALL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 884 SLTYADLIPVPLTYMIISRDVIliaaVFYVRYRtlptprtlakyfnpcYATARLKPTFISKVNTAVQLILVAASLAAPVF 963
Cdd:COG0558 85 GLVLLGLLPAWLALLILLRELL----VSYLRAR---------------AAALGVVASYLGKAKTVLQLVAILLLLLGLPL 145
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1538017668 964 NYAdsiylqILWCCTAFTtaasAYSYYHYGRKTVQVIKGK 1003
Cdd:COG0558 146 LGV------LLWLAAVLT----LLSGIQYLVAARRALRAR 175
|
|
| PLN02794 |
PLN02794 |
cardiolipin synthase |
810-1001 |
9.51e-32 |
|
cardiolipin synthase
Pssm-ID: 178391 Cd Length: 341 Bit Score: 127.27 E-value: 9.51e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 810 IPNMLSMTRIGLAPVLGYLILEEDFNVALGVFALAGLTDLLDGFIARNwANQKSALGSALDPLADKVLISILYVSLTYAD 889
Cdd:PLN02794 144 LPNLISISRLVSGPVIGWMIVNEMYLSAFVGLAISGASDWLDGYVARK-MGINSVVGSYLDPLADKVLIGCVALAMVEKD 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 890 LIPVPLTYMIISRDVILIAAVFYVRYRTLPTP-RTLAKYFN-PCYATARLKPTFISKVNTAVQLILVAASLAAPVFNYAD 967
Cdd:PLN02794 223 LLHPGLVGLVVLRDVALVGGAVYKRASSLGWKwNSWSDFFNlDGTRPEKVEPLFISKVNTVFQLMLVAAALLQPEFGTEE 302
|
170 180 190
....*....|....*....|....*....|....*..
gi 1538017668 968 SI-YLQILWCCTAFTTAAS--AYSYYHYGRKTVQVIK 1001
Cdd:PLN02794 303 TQnYITYLSWLVASTTVAStaAYGVQYMKNRPRLLAK 339
|
|
| MCM_OB |
pfam17207 |
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ... |
199-330 |
2.23e-31 |
|
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.
Pssm-ID: 465381 [Multi-domain] Cd Length: 126 Bit Score: 119.12 E-value: 2.23e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 199 HLKNVRANCYGKYISIRGTVVRVGNIKPLCTKMAFRCAACGEIQSFplpdgKYNLPTKCPVPACRGK-SFTPLRSspLTV 277
Cdd:pfam17207 1 SIRDLRSEHIGKLVSVSGIVTRTSEVRPKLKKATFTCRKCGHTVGV-----KITEPTKCPNPECGNKdPFKLVHE--KSK 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1538017668 278 TVDWQLIKIQElMSDaQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKV 330
Cdd:pfam17207 74 FVDFQKIKIQE-SPE-EVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGIYRV 124
|
|
| CDP-OH_P_transf |
pfam01066 |
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ... |
808-981 |
1.82e-30 |
|
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.
Pssm-ID: 460049 [Multi-domain] Cd Length: 157 Bit Score: 117.66 E-value: 1.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 808 WTIPNMLSMTRIGLAPVLGYLILE-EDFNVALGVFALAGLTDLLDGFIARnWANQKSALGSALDPLADKVLISILYVSLT 886
Cdd:pfam01066 1 LNLPNLLTLLRILLVPVFVVLLLGpGNRILAAVVFALAALTDFLDGKIAR-KLNQVTDFGKFLDPLADKLLVAAALIALS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 887 YADLIPVPLTYMIISRDVILIAAVFYVRYRTLPTPrtlAKYFnpcyatarlkptfiSKVNTAVQLILVAASLAAPVFNYA 966
Cdd:pfam01066 80 ILGLLPWWFVVVILVRELGVTLLRFNVARKGVVIP---ASRG--------------GKIKTALQMVAIGLLLLPLPGLLP 142
|
170
....*....|....*
gi 1538017668 967 dsIYLQILWCCTAFT 981
Cdd:pfam01066 143 --LAGILLWLALALT 155
|
|
| pgsA |
TIGR00560 |
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ... |
810-981 |
3.20e-20 |
|
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]
Pssm-ID: 273139 [Multi-domain] Cd Length: 182 Bit Score: 89.33 E-value: 3.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 810 IPNMLSMTRIGLAPVLGYLILEEDFNVAL------GVFALAGLTDLLDGFIARNWaNQKSALGSALDPLADKVLISILYV 883
Cdd:TIGR00560 3 IPNWLTLFRIIALPIFILFFLENVLPIQVspfigaLLFIFAAVTDWLDGYLARKW-NQVSNFGKFLDPLADKVLVLAVLI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 884 SLTYADLIPVPLTYMIISRDvILIAAVfyvryrtlptpRTLAKYFNPCYATarlkpTFISKVNTAVQLILVAASLAAPV- 962
Cdd:TIGR00560 82 ILVYHGYVPAWFVIVIIARE-IVISGL-----------RVLAAEKKVVIAA-----NWLGKWKTTAQMVAIGALLLWRLt 144
|
170 180
....*....|....*....|
gi 1538017668 963 -FNYADSIYLQILWCCTAFT 981
Cdd:TIGR00560 145 fKIFFEFIVQLLYYIAAFFT 164
|
|
| MCM8_WHD |
cd22247 |
winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; ... |
766-806 |
2.99e-12 |
|
winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; MCM8 is a DNA helicase that is a component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is also required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting its nuclease activity. This model corresponds to the C-terminal winged-helix domain (WHD) of MCM8, which mediates protein-nucleic acid interaction, as well as protein-protein interaction.
Pssm-ID: 439328 [Multi-domain] Cd Length: 66 Bit Score: 62.50 E-value: 2.99e-12
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1538017668 766 RSTAKRFISALNSIAERTYNNIFQFHQLRQIAKELNIQYEN 806
Cdd:cd22247 1 RKQAKRFVSALQREAERKGNNLFTVDELKQIAKELGLQVDD 41
|
|
| PRK10832 |
PRK10832 |
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; |
810-908 |
7.57e-11 |
|
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
Pssm-ID: 182763 [Multi-domain] Cd Length: 182 Bit Score: 62.17 E-value: 7.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 810 IPNMLSMTRIGLAP--VLG-YLILEEDFNVALGVFALAGLTDLLDGFIARNWaNQKSALGSALDPLADKVLISILYVSLT 886
Cdd:PRK10832 5 IPTLLTLFRVILIPffVLVfYLPFTWAPFVCALIFCVAAVTDWFDGFLARRW-NQSTRFGAFLDPVADKVMVAIAMVLVT 83
|
90 100
....*....|....*....|....*
gi 1538017668 887 ---YADLIPVPLTYMiISRDVILIA 908
Cdd:PRK10832 84 ehyHSWWVTLPAATM-IAREIIISA 107
|
|
| AAA |
cd00009 |
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ... |
428-586 |
3.51e-07 |
|
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.
Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 50.61 E-value: 3.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 428 YADDKNRIPIRGDPHILIVGDPGLGKSQMLQA-ACNVAPRGVYVCgnTTTSSGLTVTLSKDSSSGDFALEA--GALVLGD 504
Cdd:cd00009 7 IEALREALELPPPKNLLLYGPPGTGKTTLARAiANELFRPGAPFL--YLNASDLLEGLVVAELFGHFLVRLlfELAEKAK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 505 QGICGIDEFDKMGNQ-HQALLEAMEQQSISLAKagvvcslPARTSIIAAANPvgghynkaktvSENLKMGSALLSRFDLV 583
Cdd:cd00009 85 PGVLFIDEIDSLSRGaQNALLRVLETLNDLRID-------RENVRVIGATNR-----------PLLGDLDRALYDRLDIR 146
|
...
gi 1538017668 584 FIL 586
Cdd:cd00009 147 IVI 149
|
|
| PLN02558 |
PLN02558 |
CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase |
809-908 |
1.93e-06 |
|
CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase
Pssm-ID: 166199 Cd Length: 203 Bit Score: 49.64 E-value: 1.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 809 TIPNMLSMTRIGLAPVLGYLILEEDF---NVALGVFALAGLTDLLDGFIARNwANQKSALGSALDPLADKVLIS---ILY 882
Cdd:PLN02558 10 TLPTVLTLGRVAAVPLLVATFYVDSWwgrTATTSIFIAAAITDWLDGYLARK-MKLGTAFGAFLDPVADKLMVAaalILL 88
|
90 100 110
....*....|....*....|....*....|...
gi 1538017668 883 VS--LTYADLIPVPLTYM-----IISRDVILIA 908
Cdd:PLN02558 89 CSrpLEVAVLGEVPWLFTvpaiaIIGREITMSA 121
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
442-580 |
7.31e-05 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 43.44 E-value: 7.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 442 HILIVGDPGLGKSQMLQaacnvaprgvYVCGNTTTSSGLTVTLSKDSSSGDF-----------ALEAGALVLGDQ--GIC 508
Cdd:pfam07728 1 GVLLVGPPGTGKTELAE----------RLAAALSNRPVFYVQLTRDTTEEDLfgrrnidpggaSWVDGPLVRAARegEIA 70
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1538017668 509 GIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPA-RTSIIAAANPVGGHYNkaktvsenlKMGSALLSRF 580
Cdd:pfam07728 71 VLDEINRANPDVLnSLLSLLDERRLLLPDGGELVKAAPdGFRLIATMNPLDRGLN---------ELSPALRSRF 135
|
|
| PssA |
COG1183 |
Phosphatidylserine synthase [Lipid transport and metabolism]; |
810-935 |
9.39e-05 |
|
Phosphatidylserine synthase [Lipid transport and metabolism];
Pssm-ID: 440796 [Multi-domain] Cd Length: 237 Bit Score: 45.19 E-value: 9.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 810 IPNMLSMtrigLAPVLGYL----ILEEDFNVALGVFALAGLTDLLDGFIARnWANQKSALGSALDPLADkvLIS------ 879
Cdd:COG1183 12 LPNLFTL----LNLFCGFLaivaAIEGDFELAALLILLAAVFDGLDGRVAR-LLNVQSEFGAELDSLAD--MVSfgvapa 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 880 -ILYVSLtyadLIPVPLTYMIISRdVILIAAVFY-VRYRTlpTPRTLAKYFN--PCYATA 935
Cdd:COG1183 85 lLLYQWG----LLPLGGLGWLAAF-LFAACSALRlARFNV--KTDDDKNYFVglPSPAAA 137
|
|
| PRK09862 |
PRK09862 |
ATP-dependent protease; |
496-618 |
4.78e-04 |
|
ATP-dependent protease;
Pssm-ID: 182120 [Multi-domain] Cd Length: 506 Bit Score: 43.81 E-value: 4.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 496 EAGALVLGDQGICGIDEFDKMGNQH-QALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPV-GGHY--NKAKTVSENL- 570
Cdd:PRK09862 286 GPGEISLAHNGVLFLDELPEFERRTlDALREPIESGQIHLSRTRAKITYPARFQLVAAMNPSpTGHYqgNHNRCTPEQTl 365
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1538017668 571 ----KMGSALLSRFDLVF-ILLDTPNeqhdhLLSEHVIairagkqRAVSSATV 618
Cdd:PRK09862 366 rylnRLSGPFLDRFDLSLeIPLPPPG-----ILSKTVV-------PGESSATV 406
|
|
| RadA_SMS_N |
cd01121 |
bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a ... |
443-472 |
6.08e-04 |
|
bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a role in recombination and recombinational repair of DNA damaged by UV radiation, X-rays, and chemical agent and is responsible for the stabilization or processing of branched DNA molecules.
Pssm-ID: 410866 [Multi-domain] Cd Length: 268 Bit Score: 42.90 E-value: 6.08e-04
10 20 30
....*....|....*....|....*....|....
gi 1538017668 443 ILIVGDPGLGKSQ-MLQAACNVAPRG---VYVCG 472
Cdd:cd01121 85 VLIGGDPGIGKSTlLLQVAARLAQRGgkvLYVSG 118
|
|
| Sms |
COG1066 |
DNA repair protein RadA/Sms, contains AAA+ ATPase domain [Replication, recombination and ... |
443-472 |
1.62e-03 |
|
DNA repair protein RadA/Sms, contains AAA+ ATPase domain [Replication, recombination and repair];
Pssm-ID: 440685 [Multi-domain] Cd Length: 453 Bit Score: 41.96 E-value: 1.62e-03
10 20 30
....*....|....*....|....*....|....
gi 1538017668 443 ILIVGDPGLGKSQ-MLQAACNVAPRG---VYVCG 472
Cdd:COG1066 92 VLIGGEPGIGKSTlLLQVAARLAKKGgkvLYVSG 125
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
442-588 |
6.69e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 38.12 E-value: 6.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538017668 442 HILIVGDPGLGKSQMLQAACNVAPRG----VYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLG--------DQGICG 509
Cdd:smart00382 4 VILIVGPPGSGKTTLARALARELGPPgggvIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLalalarklKPDVLI 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1538017668 510 IDEFDKMGNQHQALLEAMEQQSISLAKAgvvcSLPARTSIIAAANPvgghynkaktvsENLKMGSALLSRFDLVFILLD 588
Cdd:smart00382 84 LDEITSLLDAEQEALLLLLEELRLLLLL----KSEKNLTVILTTND------------EKDLGPALLRRRFDRRIVLLL 146
|
|
| |
