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Conserved domains on  [gi|1552559213|ref|XP_027493360|]
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microtubule-associated protein 2 isoform X24 [Corapipo altera]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 339-368 1.05e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 62.04  E-value: 1.05e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 1552559213 339 VQIVTKKIDLSHVTSKCGSLKNIHHKPGGG 368
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 370-400 8.53e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 56.65  E-value: 8.53e-11
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1552559213 370 VKIESVKLDFKeKAQAKVGSLENAHHVPGGG 400
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 308-337 1.32e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 47.41  E-value: 1.32e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1552559213 308 RVINQPLpDLKNVRSKIGSTDNIKYQPKGG 337
Cdd:pfam00418   2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 157-335 9.20e-03

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 38.52  E-value: 9.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1552559213 157 TNQAPGVFKQAKEKLSDGVSKSPEKRSSLPRPSSILPPRRGASGDRDREENSLSLTASLSSS----------------IR 220
Cdd:PTZ00449  602 SAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPkppfdpkfkekfyddyLD 681

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1552559213 221 RTTRSEPIRSRTGKSGTSTPTTPGSTAITPGTPPSYASRTPGT-PGTPSYSRTPhtPGTPKSAILVPTEkkvaiIRTPPK 299
Cdd:PTZ00449  682 AAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKlPRDEEFPFEP--IGDPDAEQPDDIE-----FFTPPE 754

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1552559213 300 SPATPKQLRVINQPLPDL-------KNVRSKIGSTDNIKYQPK 335
Cdd:PTZ00449  755 EERTFFHETPADTPLPDIlaeefkeEDIHAETGEPDEAMKRPD 797
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 339-368 1.05e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 62.04  E-value: 1.05e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 1552559213 339 VQIVTKKIDLSHVTSKCGSLKNIHHKPGGG 368
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 370-400 8.53e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 56.65  E-value: 8.53e-11
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1552559213 370 VKIESVKLDFKeKAQAKVGSLENAHHVPGGG 400
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 308-337 1.32e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 47.41  E-value: 1.32e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1552559213 308 RVINQPLpDLKNVRSKIGSTDNIKYQPKGG 337
Cdd:pfam00418   2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 157-335 9.20e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 38.52  E-value: 9.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1552559213 157 TNQAPGVFKQAKEKLSDGVSKSPEKRSSLPRPSSILPPRRGASGDRDREENSLSLTASLSSS----------------IR 220
Cdd:PTZ00449  602 SAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPkppfdpkfkekfyddyLD 681

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1552559213 221 RTTRSEPIRSRTGKSGTSTPTTPGSTAITPGTPPSYASRTPGT-PGTPSYSRTPhtPGTPKSAILVPTEkkvaiIRTPPK 299
Cdd:PTZ00449  682 AAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKlPRDEEFPFEP--IGDPDAEQPDDIE-----FFTPPE 754

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1552559213 300 SPATPKQLRVINQPLPDL-------KNVRSKIGSTDNIKYQPK 335
Cdd:PTZ00449  755 EERTFFHETPADTPLPDIlaeefkeEDIHAETGEPDEAMKRPD 797
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 339-368 1.05e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 62.04  E-value: 1.05e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 1552559213 339 VQIVTKKIDLSHVTSKCGSLKNIHHKPGGG 368
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 370-400 8.53e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 56.65  E-value: 8.53e-11
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1552559213 370 VKIESVKLDFKeKAQAKVGSLENAHHVPGGG 400
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 308-337 1.32e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 47.41  E-value: 1.32e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1552559213 308 RVINQPLpDLKNVRSKIGSTDNIKYQPKGG 337
Cdd:pfam00418   2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 157-335 9.20e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 38.52  E-value: 9.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1552559213 157 TNQAPGVFKQAKEKLSDGVSKSPEKRSSLPRPSSILPPRRGASGDRDREENSLSLTASLSSS----------------IR 220
Cdd:PTZ00449  602 SAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPkppfdpkfkekfyddyLD 681

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1552559213 221 RTTRSEPIRSRTGKSGTSTPTTPGSTAITPGTPPSYASRTPGT-PGTPSYSRTPhtPGTPKSAILVPTEkkvaiIRTPPK 299
Cdd:PTZ00449  682 AAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKlPRDEEFPFEP--IGDPDAEQPDDIE-----FFTPPE 754

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1552559213 300 SPATPKQLRVINQPLPDL-------KNVRSKIGSTDNIKYQPK 335
Cdd:PTZ00449  755 EERTFFHETPADTPLPDIlaeefkeEDIHAETGEPDEAMKRPD 797
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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