NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1620184944|ref|XP_028541407|]
View 

acyl-CoA synthetase, putative [Plasmodium sp. gorilla clade G2]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AFD_class_I super family cl17068
Adenylate forming domain, Class I superfamily; This family includes acyl- and aryl-CoA ligases, ...
 3-85 3.76e-34

Adenylate forming domain, Class I superfamily; This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.


The actual alignment was detected with superfamily member PTZ00342:

Pssm-ID: 473059 [Multi-domain]  Cd Length: 746  Bit Score: 122.52  E-value: 3.76e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620184944   3 VVFNISVFVIYLIYIKPNFSQFTSEYEVYSEICENSANENESCVYCMKDHKRKSSKYVYKHIMKMFFENNSLNKNKIALI 82
Cdd:PTZ00342    2 IIYSLCLFFIYLIYVAPCCTQSLSKGKGYSEICEKATNENESSVYCMKDHKKKSSLYVYKHIMKLLLEKYKLNNNKIAIV 81


                  ...
gi 1620184944  83 EHE 85
Cdd:PTZ00342   82 EHS 84
 
Name Accession Description Interval E-value
PTZ00342 PTZ00342
acyl-CoA synthetase; Provisional
 3-85 3.76e-34

acyl-CoA synthetase; Provisional


Pssm-ID: 240370 [Multi-domain]  Cd Length: 746  Bit Score: 122.52  E-value: 3.76e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620184944   3 VVFNISVFVIYLIYIKPNFSQFTSEYEVYSEICENSANENESCVYCMKDHKRKSSKYVYKHIMKMFFENNSLNKNKIALI 82
Cdd:PTZ00342    2 IIYSLCLFFIYLIYVAPCCTQSLSKGKGYSEICEKATNENESSVYCMKDHKKKSSLYVYKHIMKLLLEKYKLNNNKIAIV 81


                  ...
gi 1620184944  83 EHE 85
Cdd:PTZ00342   82 EHS 84
 
Name Accession Description Interval E-value
PTZ00342 PTZ00342
acyl-CoA synthetase; Provisional
 3-85 3.76e-34

acyl-CoA synthetase; Provisional


Pssm-ID: 240370 [Multi-domain]  Cd Length: 746  Bit Score: 122.52  E-value: 3.76e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620184944   3 VVFNISVFVIYLIYIKPNFSQFTSEYEVYSEICENSANENESCVYCMKDHKRKSSKYVYKHIMKMFFENNSLNKNKIALI 82
Cdd:PTZ00342    2 IIYSLCLFFIYLIYVAPCCTQSLSKGKGYSEICEKATNENESSVYCMKDHKKKSSLYVYKHIMKLLLEKYKLNNNKIAIV 81


                  ...
gi 1620184944  83 EHE 85
Cdd:PTZ00342   82 EHS 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH