|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00176 super family |
cl31413 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
2033-2862 |
7.70e-59 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
The actual alignment was detected with superfamily member PTZ00176:
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 225.30 E-value: 7.70e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2033 AEVYLPTRKEKICFRGLDgkYDNTPNeVKDEKSLFEHLIKLAAIEGHNLgeyykakkgkgQNDEKYKYEVSECSALKYSF 2112
Cdd:PTZ00176 119 AGACAPFRRQNMCDKNLE--YLINKN-TENTHDLLGNVLVTAKYEGESI-----------VNNHPDKDKSSVCTALARSF 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2113 LDLRDIILGHDM-TETDKEETEKNLQKIFKEEYDDDKDAG--------KPGSTY--RRNFWKSNEKCVWNAMKCGYKK-- 2179
Cdd:PTZ00176 185 ADIGDIVRGKDMfKRNKHDNVENGLREVFKKIYEGLKNNGarehykevKNGNYIklREDWWTANRDQVWKAMTCVAPEna 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2180 --------GCDDTTTLSGCDQMPDDTTYPVgttrdsgKNY--QFLRWFAEWGEDYCGHYAKEFATLQDKCKDVDCKK--T 2247
Cdd:PTZ00176 265 yfrkteadGIGISSLILPYSKCGRDTDPPV-------VDYipQRLRWMSEWSEYFCNVLNKEIDEMNNQCKDCEMSRrcN 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2248 ESEEQKKQQDCKSQCDKYQNFIKDWKKQYEKQKTKFEA--DKKQKNLYEKDKEANEA--------------SDARVFLHK 2311
Cdd:PTZ00176 338 NDTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMElyNKASTNITKQNSSAPERgyrrnhrrrgydddTNVQLFLKK 417
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2312 KLQKACQNSSKPGASGSTECNCMSDISSPTTGGGTDTPKSLEEIPSEYQKQCECDTprppnppkpmpnpnpqkpdsqkpn 2391
Cdd:PTZ00176 418 VIENNECKVESLGKYLDKTSHCGNYNFNYDNTPGSNRSNAFEITPEKFKKACKCKI------------------------ 473
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2392 qkdtnpdsssgpPDPnsgqpgspgqgggsqqpggpkpdttpspgepdsgqssvhppspgvhpagpsvqpaqqdkfkeLDE 2471
Cdd:PTZ00176 474 ------------PNP--------------------------------------------------------------LEK 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2472 CPDTK-QSYCSKYGKFSGrpgCRHKKTNYDSFENWNKLTLNEKDDNYGVQVPPRRKNLCFPMLYGSKLNKLTLDDFKKHL 2550
Cdd:PTZ00176 480 CPNEEnKNVCTRFDKVYS---CTSLSFKNDLSEWNNSGVKNKENDNNGVLVPPRRRNLCINLFSKKDYKMKDENDFKEDL 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2551 LNSAATEAKNLMNYHKDNEKLAFQAIKYSFGDYGNLIKGDDLnsKNDdiASKINEAITKLQSQNNNSvssgggtsattTT 2630
Cdd:PTZ00176 557 LNAAFSQGKLLGKKYSNYSNEAYEAMKFSYADYSDIVKGTDM--MND--LKKLNKELNTLLKETEKG-----------DI 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2631 KFERKNWWDKNKKHIWHVMLCQYTGTDKDQHCE----DYKEIDNIPQFLRWLEEWARKYCSERTKLADMVSKECKTNI-- 2704
Cdd:PTZ00176 622 SVDRKTWWDDNKNVVWNAMLCGYKTENENQQLNsswcNVPDDDNIDQFLRWLTEWAQQYCKEKLIKAHIINTKCKDIVeg 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2705 -KNIDFIkpDKKDEKCVIALNSYKKLFHNRHLEWENLKKKYKKDKEtkdTTSANSNSYTENDAEAYLKKRCPECICTYDD 2783
Cdd:PTZ00176 702 rKHKSMV--DITDVECKRLFIDYEEWFRYRYNQWKGLSEKYIKIKK---SKNSGVNIPSEECAASYVTKHCNGCICNLRD 776
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2784 LEKISNYENDSNNVYKKLIQQSIYDTNENASILKKLLTFDEHGPEIAKKAFDAAGKIIPDALQ----VAKEAAKVAEELG 2859
Cdd:PTZ00176 777 MEDIHKNINNQNELMKEMINIIKFDTDQYRTQLQNISNSMEINPKSVKTAVDTTKDIVSYGLAgtmgVAAIGLQAGDFLG 856
|
...
gi 1620185022 2860 KNV 2862
Cdd:PTZ00176 857 KKI 859
|
|
| PTZ00176 super family |
cl31413 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
388-834 |
1.80e-47 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
The actual alignment was detected with superfamily member PTZ00176:
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 188.32 E-value: 1.80e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 388 GAGQGVSVTTTSVPGPKTVMQIAQDIQSQAKKDAEgrlgggKLDDLKGNIENAQFKNRNKGS-----DFNGDPCKMDKSK 462
Cdd:PTZ00176 1 MALKKGVINESKLSARNVLENIGNEIKDKRENESK------YTDKLKGSLWEARFSDGLSSSfgdvrSGYYDSCSLDHKF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 463 HTN---DVRSDGEPCKGKGGDNPDRFVIGKQWGTK-KGEVDQNNNEVLLPPRRLDMCTSNLENLARsgqnpdfiNNGSVN 538
Cdd:PTZ00176 75 HTNinnGYPPARNPCDGRNQNRFDENGESYCNSDKiRGNENNSNAGACAPFRRQNMCDKNLEYLIN--------KNTENT 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 539 DSFTGDVLLAAKEEAENILKLYGNsNDQSGMCRAVRASFADLGDIIRGTDIWEKNDDmKNLQGHLDKIFAKI----KDEK 614
Cdd:PTZ00176 147 HDLLGNVLVTAKYEGESIVNNHPD-KDKSSVCTALARSFADIGDIVRGKDMFKRNKH-DNVENGLREVFKKIyeglKNNG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 615 GNGKYTggENESPPYKTLRSDWWSANRDQVWDAIKCQIGD---LFAASDEKIDRATGKVVGAFCGYNDTTPVDDYIPQKL 691
Cdd:PTZ00176 225 AREHYK--EVKNGNYIKLREDWWTANRDQVWKAMTCVAPEnayFRKTEADGIGISSLILPYSKCGRDTDPPVVDYIPQRL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 692 RWLAEWNENYCKQMKKDFNAVKEQCTLCKNIGEGKCEKDNKKCDMCSGMCDTYKENVEKWKTQWTKHQQQYTSLY----- 766
Cdd:PTZ00176 303 RWMSEWSEYFCNVLNKEIDEMNNQCKDCEMSRRCNNDTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYnkast 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 767 -------SNP---------------NGNDKEFIQKLKQNNNYSnsadfVDSMGGY----RYCKDTTQRETKEQG-NEDYL 819
Cdd:PTZ00176 383 nitkqnsSAPergyrrnhrrrgyddDTNVQLFLKKVIENNECK-----VESLGKYldktSHCGNYNFNYDNTPGsNRSNA 457
|
490
....*....|....*
gi 1620185022 820 FKEKPKEFKDECGCK 834
Cdd:PTZ00176 458 FEITPEKFKKACKCK 472
|
|
| PTZ00176 super family |
cl31413 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1601-2291 |
1.74e-41 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
The actual alignment was detected with superfamily member PTZ00176:
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 169.06 E-value: 1.74e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1601 CNCDTSKHTQDTD------NPCdknyteYGCTEKKFDKNIwsSTYVTHPTDRG-------KVFAPPRRNSMCIGWLFSKI 1667
Cdd:PTZ00176 68 CSLDHKFHTNINNgypparNPC------DGRNQNRFDENG--ESYCNSDKIRGnennsnaGACAPFRRQNMCDKNLEYLI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1668 GDKDSSgkplTKDAAKNQLRlklidaargESHYLHKYYTKNSGTPDTTKYCSALRRSFYDYGDMVKGTDLWSAGYSPRVE 1747
Cdd:PTZ00176 140 NKNTEN----THDLLGNVLV---------TAKYEGESIVNNHPDKDKSSVCTALARSFADIGDIVRGKDMFKRNKHDNVE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1748 KNIYDVFK--------------MPDTAGGNtpsdmdIVKDRESWWNTHKREIWQAMNCGGTN-----KCDTSGSDY---- 1804
Cdd:PTZ00176 207 NGLREVFKkiyeglknngarehYKEVKNGN------YIKLREDWWTANRDQVWKAMTCVAPEnayfrKTEADGIGIssli 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1805 -----------PTVYDSHDEFLRWFIEWGENFCTQKQHYMSELQTIC----MDKSCNTLCGGSTCEPCQKQCAKYHKWLF 1869
Cdd:PTZ00176 281 lpyskcgrdtdPPVVDYIPQRLRWMSEWSEYFCNVLNKEIDEMNNQCkdceMSRRCNNDTEGEKCKKCKEQCQIFKELVS 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1870 TKKGEWNgqkekykeeykKQGAKYQNIYAHTKKKPDKyieeyakicEGADLNDVFKRQDNQYKPYKKKC------KRCID 1943
Cdd:PTZ00176 361 KWKNQFD-----------KQSMKYMELYNKASTNITK---------QNSSAPERGYRRNHRRRGYDDDTnvqlflKKVIE 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1944 KLTQDVVQKIKYPGKSSPTDNIDsFCEKSCDNSGNESLYEKHIEKDDKYSKIK------------GQSNCEGLKKAA--- 2008
Cdd:PTZ00176 421 NNECKVESLGKYLDKTSHCGNYN-FNYDNTPGSNRSNAFEITPEKFKKACKCKipnplekcpneeNKNVCTRFDKVYsct 499
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2009 ----EGKKIKWNNSDEKDYEYLKNrqvpaEVYLPTRKEKICFrGLDGKYDntpNEVKDEKSLFEHLIKLAAIEGHNLGey 2084
Cdd:PTZ00176 500 slsfKNDLSEWNNSGVKNKENDNN-----GVLVPPRRRNLCI-NLFSKKD---YKMKDENDFKEDLLNAAFSQGKLLG-- 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2085 ykaKKGKGQNDEKYKyevsecsALKYSFLDLRDIILGHDMTeTDKEETEKNLQKIFKEEYDDDKdagkpgSTYRRNFWKS 2164
Cdd:PTZ00176 569 ---KKYSNYSNEAYE-------AMKFSYADYSDIVKGTDMM-NDLKKLNKELNTLLKETEKGDI------SVDRKTWWDD 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2165 NEKCVWNAMKCGYKKGCDDTTTLSGCDQMPDDTTYPvgttrdsgknyQFLRWFAEWGEDYCGHYAKEFATLQDKCKD-VD 2243
Cdd:PTZ00176 632 NKNVVWNAMLCGYKTENENQQLNSSWCNVPDDDNID-----------QFLRWLTEWAQQYCKEKLIKAHIINTKCKDiVE 700
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 1620185022 2244 CKKTESEEQKKQQDCKSQCDKYQNFIKDWKKQYEKQKTKFEADKKQKN 2291
Cdd:PTZ00176 701 GRKHKSMVDITDVECKRLFIDYEEWFRYRYNQWKGLSEKYIKIKKSKN 748
|
|
| PTZ00176 super family |
cl31413 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1204-1930 |
2.84e-30 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
The actual alignment was detected with superfamily member PTZ00176:
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 132.08 E-value: 2.84e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1204 LNEGVKSEKMQSIQGEYEDLDSKCDKLRGTEKNYVQALINNSEKDREKICHECENQTTKPSPTDKCD-----------GI 1272
Cdd:PTZ00176 3 LKKGVINESKLSARNVLENIGNEIKDKRENESKYTDKLKGSLWEARFSDGLSSSFGDVRSGYYDSCSldhkfhtninnGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1273 GNASN-CQTKNYNELDpkkgnkeRNKEWLCKN--IQNTSTDVKQDVCVPPRTQPLCIANMytkQAIVDNAFSSEENMKKA 1349
Cdd:PTZ00176 83 PPARNpCDGRNQNRFD-------ENGESYCNSdkIRGNENNSNAGACAPFRRQNMCDKNL---EYLINKNTENTHDLLGN 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1350 LKAAIKKETELLYTYYTTTKKKTgtpppgFCEAAYRSFNDFKHMVLGDMLWKPESIKKVQEKIGEIIKQ--SGTSGKTVT 1427
Cdd:PTZ00176 153 VLVTAKYEGESIVNNHPDKDKSS------VCTALARSFADIGDIVRGKDMFKRNKHDNVENGLREVFKKiyEGLKNNGAR 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1428 --------------REEWWKQHEVEFWEAAKCGIKDSG----NKSATGDCPRLI-------NDDD--------QFEWWAK 1474
Cdd:PTZ00176 227 ehykevkngnyiklREDWWTANRDQVWKAMTCVAPENAyfrkTEADGIGISSLIlpyskcgRDTDppvvdyipQRLRWMS 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1475 EWSDDFYHKRHEVLKEFDKVCNTDRTGK--NTDCEGTNGQmkansKCKPKCDEYKNFLSKKRDEWNKNFKIYLqtkeEEA 1552
Cdd:PTZ00176 307 EWSEYFCNVLNKEIDEMNNQCKDCEMSRrcNNDTEGEKCK-----KCKEQCQIFKELVSKWKNQFDKQSMKYM----ELY 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1553 NKNTSSVNTKEYSHP-----------------NVYLLYPCTYQNCDNKymtaLLSDKQYGDK------------------ 1597
Cdd:PTZ00176 378 NKASTNITKQNSSAPergyrrnhrrrgydddtNVQLFLKKVIENNECK----VESLGKYLDKtshcgnynfnydntpgsn 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1598 ------------EKICNCDTSKHTQDTDNPCDKNYTE-----YGCTEKKFDKNI--WSSTYVTHP-TDRGKVFAPPRRNS 1657
Cdd:PTZ00176 454 rsnafeitpekfKKACKCKIPNPLEKCPNEENKNVCTrfdkvYSCTSLSFKNDLseWNNSGVKNKeNDNNGVLVPPRRRN 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1658 MCIGwLFSKigdKDSSGKPltkdaaKNQLRLKLIDAARGESHYLHKYYTKNSgtpdtTKYCSALRRSFYDYGDMVKGTDL 1737
Cdd:PTZ00176 534 LCIN-LFSK---KDYKMKD------ENDFKEDLLNAAFSQGKLLGKKYSNYS-----NEAYEAMKFSYADYSDIVKGTDM 598
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1738 WSAgySPRVEKNIYDVFKmpDTAGGntpsdmDIVKDRESWWNTHKREIWQAMNCG--GTNKCDTSGSDYPTVYDSH--DE 1813
Cdd:PTZ00176 599 MND--LKKLNKELNTLLK--ETEKG------DISVDRKTWWDDNKNVVWNAMLCGykTENENQQLNSSWCNVPDDDniDQ 668
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1814 FLRWFIEWGENFCTQKQHYMSELQTICMD----KSCNTLCGGSTCEpCQKQCAKYHKWLFTKKGEWNGqkeKYKEEYKKQ 1889
Cdd:PTZ00176 669 FLRWLTEWAQQYCKEKLIKAHIINTKCKDivegRKHKSMVDITDVE-CKRLFIDYEEWFRYRYNQWKG---LSEKYIKIK 744
|
810 820 830 840
....*....|....*....|....*....|....*....|...
gi 1620185022 1890 GAKYQNIYAHTKKKPDKYIEEYAK--ICEGADLNDVFKRQDNQ 1930
Cdd:PTZ00176 745 KSKNSGVNIPSEECAASYVTKHCNgcICNLRDMEDIHKNINNQ 787
|
|
| PFEMP super family |
cl03834 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
913-1041 |
2.14e-06 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
The actual alignment was detected with superfamily member pfam03011:
Pssm-ID: 281064 Cd Length: 154 Bit Score: 49.80 E-value: 2.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 913 FEDWLTSFFNEQQNVKSKSSDCTNitPSSGDCDGKKCRDKCPCYEKWVKRKTNEWRHFKNYYRDFQTINPTKWMSS---- 988
Cdd:pfam03011 2 FKRWVEYFLEDSIKWRKKLKSCIN--NGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGLTGKTLdeyl 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1620185022 989 -----------FKSVGNDADTYVKKKKQSELSKAYQSTSGTKS-----NNITIQDILTEESKKVTECLK 1041
Cdd:pfam03011 80 dlksfletflfYIDIKEAYGDVKELKKLEEILDEEGCSAGAESaknnkNEDAIDKLLDKEEKKANNCKE 148
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
2033-2862 |
7.70e-59 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 225.30 E-value: 7.70e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2033 AEVYLPTRKEKICFRGLDgkYDNTPNeVKDEKSLFEHLIKLAAIEGHNLgeyykakkgkgQNDEKYKYEVSECSALKYSF 2112
Cdd:PTZ00176 119 AGACAPFRRQNMCDKNLE--YLINKN-TENTHDLLGNVLVTAKYEGESI-----------VNNHPDKDKSSVCTALARSF 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2113 LDLRDIILGHDM-TETDKEETEKNLQKIFKEEYDDDKDAG--------KPGSTY--RRNFWKSNEKCVWNAMKCGYKK-- 2179
Cdd:PTZ00176 185 ADIGDIVRGKDMfKRNKHDNVENGLREVFKKIYEGLKNNGarehykevKNGNYIklREDWWTANRDQVWKAMTCVAPEna 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2180 --------GCDDTTTLSGCDQMPDDTTYPVgttrdsgKNY--QFLRWFAEWGEDYCGHYAKEFATLQDKCKDVDCKK--T 2247
Cdd:PTZ00176 265 yfrkteadGIGISSLILPYSKCGRDTDPPV-------VDYipQRLRWMSEWSEYFCNVLNKEIDEMNNQCKDCEMSRrcN 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2248 ESEEQKKQQDCKSQCDKYQNFIKDWKKQYEKQKTKFEA--DKKQKNLYEKDKEANEA--------------SDARVFLHK 2311
Cdd:PTZ00176 338 NDTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMElyNKASTNITKQNSSAPERgyrrnhrrrgydddTNVQLFLKK 417
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2312 KLQKACQNSSKPGASGSTECNCMSDISSPTTGGGTDTPKSLEEIPSEYQKQCECDTprppnppkpmpnpnpqkpdsqkpn 2391
Cdd:PTZ00176 418 VIENNECKVESLGKYLDKTSHCGNYNFNYDNTPGSNRSNAFEITPEKFKKACKCKI------------------------ 473
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2392 qkdtnpdsssgpPDPnsgqpgspgqgggsqqpggpkpdttpspgepdsgqssvhppspgvhpagpsvqpaqqdkfkeLDE 2471
Cdd:PTZ00176 474 ------------PNP--------------------------------------------------------------LEK 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2472 CPDTK-QSYCSKYGKFSGrpgCRHKKTNYDSFENWNKLTLNEKDDNYGVQVPPRRKNLCFPMLYGSKLNKLTLDDFKKHL 2550
Cdd:PTZ00176 480 CPNEEnKNVCTRFDKVYS---CTSLSFKNDLSEWNNSGVKNKENDNNGVLVPPRRRNLCINLFSKKDYKMKDENDFKEDL 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2551 LNSAATEAKNLMNYHKDNEKLAFQAIKYSFGDYGNLIKGDDLnsKNDdiASKINEAITKLQSQNNNSvssgggtsattTT 2630
Cdd:PTZ00176 557 LNAAFSQGKLLGKKYSNYSNEAYEAMKFSYADYSDIVKGTDM--MND--LKKLNKELNTLLKETEKG-----------DI 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2631 KFERKNWWDKNKKHIWHVMLCQYTGTDKDQHCE----DYKEIDNIPQFLRWLEEWARKYCSERTKLADMVSKECKTNI-- 2704
Cdd:PTZ00176 622 SVDRKTWWDDNKNVVWNAMLCGYKTENENQQLNsswcNVPDDDNIDQFLRWLTEWAQQYCKEKLIKAHIINTKCKDIVeg 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2705 -KNIDFIkpDKKDEKCVIALNSYKKLFHNRHLEWENLKKKYKKDKEtkdTTSANSNSYTENDAEAYLKKRCPECICTYDD 2783
Cdd:PTZ00176 702 rKHKSMV--DITDVECKRLFIDYEEWFRYRYNQWKGLSEKYIKIKK---SKNSGVNIPSEECAASYVTKHCNGCICNLRD 776
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2784 LEKISNYENDSNNVYKKLIQQSIYDTNENASILKKLLTFDEHGPEIAKKAFDAAGKIIPDALQ----VAKEAAKVAEELG 2859
Cdd:PTZ00176 777 MEDIHKNINNQNELMKEMINIIKFDTDQYRTQLQNISNSMEINPKSVKTAVDTTKDIVSYGLAgtmgVAAIGLQAGDFLG 856
|
...
gi 1620185022 2860 KNV 2862
Cdd:PTZ00176 857 KKI 859
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
388-834 |
1.80e-47 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 188.32 E-value: 1.80e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 388 GAGQGVSVTTTSVPGPKTVMQIAQDIQSQAKKDAEgrlgggKLDDLKGNIENAQFKNRNKGS-----DFNGDPCKMDKSK 462
Cdd:PTZ00176 1 MALKKGVINESKLSARNVLENIGNEIKDKRENESK------YTDKLKGSLWEARFSDGLSSSfgdvrSGYYDSCSLDHKF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 463 HTN---DVRSDGEPCKGKGGDNPDRFVIGKQWGTK-KGEVDQNNNEVLLPPRRLDMCTSNLENLARsgqnpdfiNNGSVN 538
Cdd:PTZ00176 75 HTNinnGYPPARNPCDGRNQNRFDENGESYCNSDKiRGNENNSNAGACAPFRRQNMCDKNLEYLIN--------KNTENT 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 539 DSFTGDVLLAAKEEAENILKLYGNsNDQSGMCRAVRASFADLGDIIRGTDIWEKNDDmKNLQGHLDKIFAKI----KDEK 614
Cdd:PTZ00176 147 HDLLGNVLVTAKYEGESIVNNHPD-KDKSSVCTALARSFADIGDIVRGKDMFKRNKH-DNVENGLREVFKKIyeglKNNG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 615 GNGKYTggENESPPYKTLRSDWWSANRDQVWDAIKCQIGD---LFAASDEKIDRATGKVVGAFCGYNDTTPVDDYIPQKL 691
Cdd:PTZ00176 225 AREHYK--EVKNGNYIKLREDWWTANRDQVWKAMTCVAPEnayFRKTEADGIGISSLILPYSKCGRDTDPPVVDYIPQRL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 692 RWLAEWNENYCKQMKKDFNAVKEQCTLCKNIGEGKCEKDNKKCDMCSGMCDTYKENVEKWKTQWTKHQQQYTSLY----- 766
Cdd:PTZ00176 303 RWMSEWSEYFCNVLNKEIDEMNNQCKDCEMSRRCNNDTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYnkast 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 767 -------SNP---------------NGNDKEFIQKLKQNNNYSnsadfVDSMGGY----RYCKDTTQRETKEQG-NEDYL 819
Cdd:PTZ00176 383 nitkqnsSAPergyrrnhrrrgyddDTNVQLFLKKVIENNECK-----VESLGKYldktSHCGNYNFNYDNTPGsNRSNA 457
|
490
....*....|....*
gi 1620185022 820 FKEKPKEFKDECGCK 834
Cdd:PTZ00176 458 FEITPEKFKKACKCK 472
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
508-692 |
1.37e-42 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 154.74 E-value: 1.37e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 508 PPRRLDMCTSNLENlarsgqnpdfINNGSVNDSFT--GDVLLAAKEEAENILKLYGNSNDQ-----SGMCRAVRASFADL 580
Cdd:pfam05424 4 PPRRLHLCVKNLEK----------INSGNTTTTHDllKAVILAAKYEGFSLWHKYKKKNTKygdipSEFCRQMAYSFADI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 581 GDIIRGTDIWEKNDDMKNLQGHLDKIFAKIkdekgNGKYTGGENESPPYKTLRSDWWSANRDQVWDAIKCQigdlfAASD 660
Cdd:pfam05424 74 GDIIRGKDLYLGNNKKKKLEENLKKIFKKI-----YEKLTSKGKDDGNYYQLREDWWEANREDIWKAMTCA-----LTYG 143
|
170 180 190
....*....|....*....|....*....|....*
gi 1620185022 661 EKIDRAT---GKVVGAFCGYNDTTPVDDYIPQKLR 692
Cdd:pfam05424 144 AKYFRKTcgdGISPSTAGCNDDVPTYFDYVPQFLR 178
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1601-2291 |
1.74e-41 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 169.06 E-value: 1.74e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1601 CNCDTSKHTQDTD------NPCdknyteYGCTEKKFDKNIwsSTYVTHPTDRG-------KVFAPPRRNSMCIGWLFSKI 1667
Cdd:PTZ00176 68 CSLDHKFHTNINNgypparNPC------DGRNQNRFDENG--ESYCNSDKIRGnennsnaGACAPFRRQNMCDKNLEYLI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1668 GDKDSSgkplTKDAAKNQLRlklidaargESHYLHKYYTKNSGTPDTTKYCSALRRSFYDYGDMVKGTDLWSAGYSPRVE 1747
Cdd:PTZ00176 140 NKNTEN----THDLLGNVLV---------TAKYEGESIVNNHPDKDKSSVCTALARSFADIGDIVRGKDMFKRNKHDNVE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1748 KNIYDVFK--------------MPDTAGGNtpsdmdIVKDRESWWNTHKREIWQAMNCGGTN-----KCDTSGSDY---- 1804
Cdd:PTZ00176 207 NGLREVFKkiyeglknngarehYKEVKNGN------YIKLREDWWTANRDQVWKAMTCVAPEnayfrKTEADGIGIssli 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1805 -----------PTVYDSHDEFLRWFIEWGENFCTQKQHYMSELQTIC----MDKSCNTLCGGSTCEPCQKQCAKYHKWLF 1869
Cdd:PTZ00176 281 lpyskcgrdtdPPVVDYIPQRLRWMSEWSEYFCNVLNKEIDEMNNQCkdceMSRRCNNDTEGEKCKKCKEQCQIFKELVS 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1870 TKKGEWNgqkekykeeykKQGAKYQNIYAHTKKKPDKyieeyakicEGADLNDVFKRQDNQYKPYKKKC------KRCID 1943
Cdd:PTZ00176 361 KWKNQFD-----------KQSMKYMELYNKASTNITK---------QNSSAPERGYRRNHRRRGYDDDTnvqlflKKVIE 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1944 KLTQDVVQKIKYPGKSSPTDNIDsFCEKSCDNSGNESLYEKHIEKDDKYSKIK------------GQSNCEGLKKAA--- 2008
Cdd:PTZ00176 421 NNECKVESLGKYLDKTSHCGNYN-FNYDNTPGSNRSNAFEITPEKFKKACKCKipnplekcpneeNKNVCTRFDKVYsct 499
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2009 ----EGKKIKWNNSDEKDYEYLKNrqvpaEVYLPTRKEKICFrGLDGKYDntpNEVKDEKSLFEHLIKLAAIEGHNLGey 2084
Cdd:PTZ00176 500 slsfKNDLSEWNNSGVKNKENDNN-----GVLVPPRRRNLCI-NLFSKKD---YKMKDENDFKEDLLNAAFSQGKLLG-- 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2085 ykaKKGKGQNDEKYKyevsecsALKYSFLDLRDIILGHDMTeTDKEETEKNLQKIFKEEYDDDKdagkpgSTYRRNFWKS 2164
Cdd:PTZ00176 569 ---KKYSNYSNEAYE-------AMKFSYADYSDIVKGTDMM-NDLKKLNKELNTLLKETEKGDI------SVDRKTWWDD 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2165 NEKCVWNAMKCGYKKGCDDTTTLSGCDQMPDDTTYPvgttrdsgknyQFLRWFAEWGEDYCGHYAKEFATLQDKCKD-VD 2243
Cdd:PTZ00176 632 NKNVVWNAMLCGYKTENENQQLNSSWCNVPDDDNID-----------QFLRWLTEWAQQYCKEKLIKAHIINTKCKDiVE 700
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 1620185022 2244 CKKTESEEQKKQQDCKSQCDKYQNFIKDWKKQYEKQKTKFEADKKQKN 2291
Cdd:PTZ00176 701 GRKHKSMVDITDVECKRLFIDYEEWFRYRYNQWKGLSEKYIKIKKSKN 748
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1204-1930 |
2.84e-30 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 132.08 E-value: 2.84e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1204 LNEGVKSEKMQSIQGEYEDLDSKCDKLRGTEKNYVQALINNSEKDREKICHECENQTTKPSPTDKCD-----------GI 1272
Cdd:PTZ00176 3 LKKGVINESKLSARNVLENIGNEIKDKRENESKYTDKLKGSLWEARFSDGLSSSFGDVRSGYYDSCSldhkfhtninnGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1273 GNASN-CQTKNYNELDpkkgnkeRNKEWLCKN--IQNTSTDVKQDVCVPPRTQPLCIANMytkQAIVDNAFSSEENMKKA 1349
Cdd:PTZ00176 83 PPARNpCDGRNQNRFD-------ENGESYCNSdkIRGNENNSNAGACAPFRRQNMCDKNL---EYLINKNTENTHDLLGN 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1350 LKAAIKKETELLYTYYTTTKKKTgtpppgFCEAAYRSFNDFKHMVLGDMLWKPESIKKVQEKIGEIIKQ--SGTSGKTVT 1427
Cdd:PTZ00176 153 VLVTAKYEGESIVNNHPDKDKSS------VCTALARSFADIGDIVRGKDMFKRNKHDNVENGLREVFKKiyEGLKNNGAR 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1428 --------------REEWWKQHEVEFWEAAKCGIKDSG----NKSATGDCPRLI-------NDDD--------QFEWWAK 1474
Cdd:PTZ00176 227 ehykevkngnyiklREDWWTANRDQVWKAMTCVAPENAyfrkTEADGIGISSLIlpyskcgRDTDppvvdyipQRLRWMS 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1475 EWSDDFYHKRHEVLKEFDKVCNTDRTGK--NTDCEGTNGQmkansKCKPKCDEYKNFLSKKRDEWNKNFKIYLqtkeEEA 1552
Cdd:PTZ00176 307 EWSEYFCNVLNKEIDEMNNQCKDCEMSRrcNNDTEGEKCK-----KCKEQCQIFKELVSKWKNQFDKQSMKYM----ELY 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1553 NKNTSSVNTKEYSHP-----------------NVYLLYPCTYQNCDNKymtaLLSDKQYGDK------------------ 1597
Cdd:PTZ00176 378 NKASTNITKQNSSAPergyrrnhrrrgydddtNVQLFLKKVIENNECK----VESLGKYLDKtshcgnynfnydntpgsn 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1598 ------------EKICNCDTSKHTQDTDNPCDKNYTE-----YGCTEKKFDKNI--WSSTYVTHP-TDRGKVFAPPRRNS 1657
Cdd:PTZ00176 454 rsnafeitpekfKKACKCKIPNPLEKCPNEENKNVCTrfdkvYSCTSLSFKNDLseWNNSGVKNKeNDNNGVLVPPRRRN 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1658 MCIGwLFSKigdKDSSGKPltkdaaKNQLRLKLIDAARGESHYLHKYYTKNSgtpdtTKYCSALRRSFYDYGDMVKGTDL 1737
Cdd:PTZ00176 534 LCIN-LFSK---KDYKMKD------ENDFKEDLLNAAFSQGKLLGKKYSNYS-----NEAYEAMKFSYADYSDIVKGTDM 598
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1738 WSAgySPRVEKNIYDVFKmpDTAGGntpsdmDIVKDRESWWNTHKREIWQAMNCG--GTNKCDTSGSDYPTVYDSH--DE 1813
Cdd:PTZ00176 599 MND--LKKLNKELNTLLK--ETEKG------DISVDRKTWWDDNKNVVWNAMLCGykTENENQQLNSSWCNVPDDDniDQ 668
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1814 FLRWFIEWGENFCTQKQHYMSELQTICMD----KSCNTLCGGSTCEpCQKQCAKYHKWLFTKKGEWNGqkeKYKEEYKKQ 1889
Cdd:PTZ00176 669 FLRWLTEWAQQYCKEKLIKAHIINTKCKDivegRKHKSMVDITDVE-CKRLFIDYEEWFRYRYNQWKG---LSEKYIKIK 744
|
810 820 830 840
....*....|....*....|....*....|....*....|...
gi 1620185022 1890 GAKYQNIYAHTKKKPDKYIEEYAK--ICEGADLNDVFKRQDNQ 1930
Cdd:PTZ00176 745 KSKNSGVNIPSEECAASYVTKHCNgcICNLRDMEDIHKNINNQ 787
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
1649-1816 |
6.57e-22 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 95.42 E-value: 6.57e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1649 VFAPPRRNSMCIGWLfSKIGDKDSSgkpltkdaAKNQLRLKLIDAAR--GES--HYLHKYYTKNSGTPDTTkyCSALRRS 1724
Cdd:pfam05424 1 ACAPPRRLHLCVKNL-EKINSGNTT--------TTHDLLKAVILAAKyeGFSlwHKYKKKNTKYGDIPSEF--CRQMAYS 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1725 FYDYGDMVKGTDLWSaGYSPR--VEKNIYDVF-KMPDTAGGNTPSDMDIVKDRESWWNTHKREIWQAMNCG-------GT 1794
Cdd:pfam05424 70 FADIGDIIRGKDLYL-GNNKKkkLEENLKKIFkKIYEKLTSKGKDDGNYYQLREDWWEANREDIWKAMTCAltygakyFR 148
|
170 180 190
....*....|....*....|....*....|
gi 1620185022 1795 NKCDTSGS--------DYPTVYDSHDEFLR 1816
Cdd:pfam05424 149 KTCGDGISpstagcndDVPTYFDYVPQFLR 178
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
2035-2199 |
6.76e-22 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 95.42 E-value: 6.76e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2035 VYLPTRKEKICFRGLdgKYDNTPNeVKDEKSLFEHLIKLAAIEGHNLGEYYKAKKgkgqndEKYKYEVSE-CSALKYSFL 2113
Cdd:pfam05424 1 ACAPPRRLHLCVKNL--EKINSGN-TTTTHDLLKAVILAAKYEGFSLWHKYKKKN------TKYGDIPSEfCRQMAYSFA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2114 DLRDIILGHDM--TETDKEETEKNLQKIFKEEYDDDKDAGKPGSTY---RRNFWKSNEKCVWNAMKCG-------YKKGC 2181
Cdd:pfam05424 72 DIGDIIRGKDLylGNNKKKKLEENLKKIFKKIYEKLTSKGKDDGNYyqlREDWWEANREDIWKAMTCAltygakyFRKTC 151
|
170
....*....|....*...
gi 1620185022 2182 DDTTTLSGCDQMPDDTTY 2199
Cdd:pfam05424 152 GDGISPSTAGCNDDVPTY 169
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
1315-1459 |
5.61e-07 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 52.28 E-value: 5.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1315 VCVPPRTQPLCIANMytkQAIVDNAFSSEENMKKALKAAIKKETELLYTYYTTTKKKTGTPPPGFCEAAYRSFNDFKHMV 1394
Cdd:pfam05424 1 ACAPPRRLHLCVKNL---EKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGDIPSEFCRQMAYSFADIGDII 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1620185022 1395 LG-DMLWKPESIKKVQEKIGEIIKQSG---------TSGKTVTREEWWKQHEVEFWEAAKCGIKDSGNKSATGDC 1459
Cdd:pfam05424 78 RGkDLYLGNNKKKKLEENLKKIFKKIYekltskgkdDGNYYQLREDWWEANREDIWKAMTCALTYGAKYFRKTCG 152
|
|
| PFEMP |
pfam03011 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
913-1041 |
2.14e-06 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
Pssm-ID: 281064 Cd Length: 154 Bit Score: 49.80 E-value: 2.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 913 FEDWLTSFFNEQQNVKSKSSDCTNitPSSGDCDGKKCRDKCPCYEKWVKRKTNEWRHFKNYYRDFQTINPTKWMSS---- 988
Cdd:pfam03011 2 FKRWVEYFLEDSIKWRKKLKSCIN--NGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGLTGKTLdeyl 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1620185022 989 -----------FKSVGNDADTYVKKKKQSELSKAYQSTSGTKS-----NNITIQDILTEESKKVTECLK 1041
Cdd:pfam03011 80 dlksfletflfYIDIKEAYGDVKELKKLEEILDEEGCSAGAESaknnkNEDAIDKLLDKEEKKANNCKE 148
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
2033-2862 |
7.70e-59 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 225.30 E-value: 7.70e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2033 AEVYLPTRKEKICFRGLDgkYDNTPNeVKDEKSLFEHLIKLAAIEGHNLgeyykakkgkgQNDEKYKYEVSECSALKYSF 2112
Cdd:PTZ00176 119 AGACAPFRRQNMCDKNLE--YLINKN-TENTHDLLGNVLVTAKYEGESI-----------VNNHPDKDKSSVCTALARSF 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2113 LDLRDIILGHDM-TETDKEETEKNLQKIFKEEYDDDKDAG--------KPGSTY--RRNFWKSNEKCVWNAMKCGYKK-- 2179
Cdd:PTZ00176 185 ADIGDIVRGKDMfKRNKHDNVENGLREVFKKIYEGLKNNGarehykevKNGNYIklREDWWTANRDQVWKAMTCVAPEna 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2180 --------GCDDTTTLSGCDQMPDDTTYPVgttrdsgKNY--QFLRWFAEWGEDYCGHYAKEFATLQDKCKDVDCKK--T 2247
Cdd:PTZ00176 265 yfrkteadGIGISSLILPYSKCGRDTDPPV-------VDYipQRLRWMSEWSEYFCNVLNKEIDEMNNQCKDCEMSRrcN 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2248 ESEEQKKQQDCKSQCDKYQNFIKDWKKQYEKQKTKFEA--DKKQKNLYEKDKEANEA--------------SDARVFLHK 2311
Cdd:PTZ00176 338 NDTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMElyNKASTNITKQNSSAPERgyrrnhrrrgydddTNVQLFLKK 417
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2312 KLQKACQNSSKPGASGSTECNCMSDISSPTTGGGTDTPKSLEEIPSEYQKQCECDTprppnppkpmpnpnpqkpdsqkpn 2391
Cdd:PTZ00176 418 VIENNECKVESLGKYLDKTSHCGNYNFNYDNTPGSNRSNAFEITPEKFKKACKCKI------------------------ 473
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2392 qkdtnpdsssgpPDPnsgqpgspgqgggsqqpggpkpdttpspgepdsgqssvhppspgvhpagpsvqpaqqdkfkeLDE 2471
Cdd:PTZ00176 474 ------------PNP--------------------------------------------------------------LEK 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2472 CPDTK-QSYCSKYGKFSGrpgCRHKKTNYDSFENWNKLTLNEKDDNYGVQVPPRRKNLCFPMLYGSKLNKLTLDDFKKHL 2550
Cdd:PTZ00176 480 CPNEEnKNVCTRFDKVYS---CTSLSFKNDLSEWNNSGVKNKENDNNGVLVPPRRRNLCINLFSKKDYKMKDENDFKEDL 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2551 LNSAATEAKNLMNYHKDNEKLAFQAIKYSFGDYGNLIKGDDLnsKNDdiASKINEAITKLQSQNNNSvssgggtsattTT 2630
Cdd:PTZ00176 557 LNAAFSQGKLLGKKYSNYSNEAYEAMKFSYADYSDIVKGTDM--MND--LKKLNKELNTLLKETEKG-----------DI 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2631 KFERKNWWDKNKKHIWHVMLCQYTGTDKDQHCE----DYKEIDNIPQFLRWLEEWARKYCSERTKLADMVSKECKTNI-- 2704
Cdd:PTZ00176 622 SVDRKTWWDDNKNVVWNAMLCGYKTENENQQLNsswcNVPDDDNIDQFLRWLTEWAQQYCKEKLIKAHIINTKCKDIVeg 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2705 -KNIDFIkpDKKDEKCVIALNSYKKLFHNRHLEWENLKKKYKKDKEtkdTTSANSNSYTENDAEAYLKKRCPECICTYDD 2783
Cdd:PTZ00176 702 rKHKSMV--DITDVECKRLFIDYEEWFRYRYNQWKGLSEKYIKIKK---SKNSGVNIPSEECAASYVTKHCNGCICNLRD 776
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2784 LEKISNYENDSNNVYKKLIQQSIYDTNENASILKKLLTFDEHGPEIAKKAFDAAGKIIPDALQ----VAKEAAKVAEELG 2859
Cdd:PTZ00176 777 MEDIHKNINNQNELMKEMINIIKFDTDQYRTQLQNISNSMEINPKSVKTAVDTTKDIVSYGLAgtmgVAAIGLQAGDFLG 856
|
...
gi 1620185022 2860 KNV 2862
Cdd:PTZ00176 857 KKI 859
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
388-834 |
1.80e-47 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 188.32 E-value: 1.80e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 388 GAGQGVSVTTTSVPGPKTVMQIAQDIQSQAKKDAEgrlgggKLDDLKGNIENAQFKNRNKGS-----DFNGDPCKMDKSK 462
Cdd:PTZ00176 1 MALKKGVINESKLSARNVLENIGNEIKDKRENESK------YTDKLKGSLWEARFSDGLSSSfgdvrSGYYDSCSLDHKF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 463 HTN---DVRSDGEPCKGKGGDNPDRFVIGKQWGTK-KGEVDQNNNEVLLPPRRLDMCTSNLENLARsgqnpdfiNNGSVN 538
Cdd:PTZ00176 75 HTNinnGYPPARNPCDGRNQNRFDENGESYCNSDKiRGNENNSNAGACAPFRRQNMCDKNLEYLIN--------KNTENT 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 539 DSFTGDVLLAAKEEAENILKLYGNsNDQSGMCRAVRASFADLGDIIRGTDIWEKNDDmKNLQGHLDKIFAKI----KDEK 614
Cdd:PTZ00176 147 HDLLGNVLVTAKYEGESIVNNHPD-KDKSSVCTALARSFADIGDIVRGKDMFKRNKH-DNVENGLREVFKKIyeglKNNG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 615 GNGKYTggENESPPYKTLRSDWWSANRDQVWDAIKCQIGD---LFAASDEKIDRATGKVVGAFCGYNDTTPVDDYIPQKL 691
Cdd:PTZ00176 225 AREHYK--EVKNGNYIKLREDWWTANRDQVWKAMTCVAPEnayFRKTEADGIGISSLILPYSKCGRDTDPPVVDYIPQRL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 692 RWLAEWNENYCKQMKKDFNAVKEQCTLCKNIGEGKCEKDNKKCDMCSGMCDTYKENVEKWKTQWTKHQQQYTSLY----- 766
Cdd:PTZ00176 303 RWMSEWSEYFCNVLNKEIDEMNNQCKDCEMSRRCNNDTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYnkast 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 767 -------SNP---------------NGNDKEFIQKLKQNNNYSnsadfVDSMGGY----RYCKDTTQRETKEQG-NEDYL 819
Cdd:PTZ00176 383 nitkqnsSAPergyrrnhrrrgyddDTNVQLFLKKVIENNECK-----VESLGKYldktSHCGNYNFNYDNTPGsNRSNA 457
|
490
....*....|....*
gi 1620185022 820 FKEKPKEFKDECGCK 834
Cdd:PTZ00176 458 FEITPEKFKKACKCK 472
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
508-692 |
1.37e-42 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 154.74 E-value: 1.37e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 508 PPRRLDMCTSNLENlarsgqnpdfINNGSVNDSFT--GDVLLAAKEEAENILKLYGNSNDQ-----SGMCRAVRASFADL 580
Cdd:pfam05424 4 PPRRLHLCVKNLEK----------INSGNTTTTHDllKAVILAAKYEGFSLWHKYKKKNTKygdipSEFCRQMAYSFADI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 581 GDIIRGTDIWEKNDDMKNLQGHLDKIFAKIkdekgNGKYTGGENESPPYKTLRSDWWSANRDQVWDAIKCQigdlfAASD 660
Cdd:pfam05424 74 GDIIRGKDLYLGNNKKKKLEENLKKIFKKI-----YEKLTSKGKDDGNYYQLREDWWEANREDIWKAMTCA-----LTYG 143
|
170 180 190
....*....|....*....|....*....|....*
gi 1620185022 661 EKIDRAT---GKVVGAFCGYNDTTPVDDYIPQKLR 692
Cdd:pfam05424 144 AKYFRKTcgdGISPSTAGCNDDVPTYFDYVPQFLR 178
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1601-2291 |
1.74e-41 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 169.06 E-value: 1.74e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1601 CNCDTSKHTQDTD------NPCdknyteYGCTEKKFDKNIwsSTYVTHPTDRG-------KVFAPPRRNSMCIGWLFSKI 1667
Cdd:PTZ00176 68 CSLDHKFHTNINNgypparNPC------DGRNQNRFDENG--ESYCNSDKIRGnennsnaGACAPFRRQNMCDKNLEYLI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1668 GDKDSSgkplTKDAAKNQLRlklidaargESHYLHKYYTKNSGTPDTTKYCSALRRSFYDYGDMVKGTDLWSAGYSPRVE 1747
Cdd:PTZ00176 140 NKNTEN----THDLLGNVLV---------TAKYEGESIVNNHPDKDKSSVCTALARSFADIGDIVRGKDMFKRNKHDNVE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1748 KNIYDVFK--------------MPDTAGGNtpsdmdIVKDRESWWNTHKREIWQAMNCGGTN-----KCDTSGSDY---- 1804
Cdd:PTZ00176 207 NGLREVFKkiyeglknngarehYKEVKNGN------YIKLREDWWTANRDQVWKAMTCVAPEnayfrKTEADGIGIssli 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1805 -----------PTVYDSHDEFLRWFIEWGENFCTQKQHYMSELQTIC----MDKSCNTLCGGSTCEPCQKQCAKYHKWLF 1869
Cdd:PTZ00176 281 lpyskcgrdtdPPVVDYIPQRLRWMSEWSEYFCNVLNKEIDEMNNQCkdceMSRRCNNDTEGEKCKKCKEQCQIFKELVS 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1870 TKKGEWNgqkekykeeykKQGAKYQNIYAHTKKKPDKyieeyakicEGADLNDVFKRQDNQYKPYKKKC------KRCID 1943
Cdd:PTZ00176 361 KWKNQFD-----------KQSMKYMELYNKASTNITK---------QNSSAPERGYRRNHRRRGYDDDTnvqlflKKVIE 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1944 KLTQDVVQKIKYPGKSSPTDNIDsFCEKSCDNSGNESLYEKHIEKDDKYSKIK------------GQSNCEGLKKAA--- 2008
Cdd:PTZ00176 421 NNECKVESLGKYLDKTSHCGNYN-FNYDNTPGSNRSNAFEITPEKFKKACKCKipnplekcpneeNKNVCTRFDKVYsct 499
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2009 ----EGKKIKWNNSDEKDYEYLKNrqvpaEVYLPTRKEKICFrGLDGKYDntpNEVKDEKSLFEHLIKLAAIEGHNLGey 2084
Cdd:PTZ00176 500 slsfKNDLSEWNNSGVKNKENDNN-----GVLVPPRRRNLCI-NLFSKKD---YKMKDENDFKEDLLNAAFSQGKLLG-- 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2085 ykaKKGKGQNDEKYKyevsecsALKYSFLDLRDIILGHDMTeTDKEETEKNLQKIFKEEYDDDKdagkpgSTYRRNFWKS 2164
Cdd:PTZ00176 569 ---KKYSNYSNEAYE-------AMKFSYADYSDIVKGTDMM-NDLKKLNKELNTLLKETEKGDI------SVDRKTWWDD 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2165 NEKCVWNAMKCGYKKGCDDTTTLSGCDQMPDDTTYPvgttrdsgknyQFLRWFAEWGEDYCGHYAKEFATLQDKCKD-VD 2243
Cdd:PTZ00176 632 NKNVVWNAMLCGYKTENENQQLNSSWCNVPDDDNID-----------QFLRWLTEWAQQYCKEKLIKAHIINTKCKDiVE 700
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 1620185022 2244 CKKTESEEQKKQQDCKSQCDKYQNFIKDWKKQYEKQKTKFEADKKQKN 2291
Cdd:PTZ00176 701 GRKHKSMVDITDVECKRLFIDYEEWFRYRYNQWKGLSEKYIKIKKSKN 748
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1204-1930 |
2.84e-30 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 132.08 E-value: 2.84e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1204 LNEGVKSEKMQSIQGEYEDLDSKCDKLRGTEKNYVQALINNSEKDREKICHECENQTTKPSPTDKCD-----------GI 1272
Cdd:PTZ00176 3 LKKGVINESKLSARNVLENIGNEIKDKRENESKYTDKLKGSLWEARFSDGLSSSFGDVRSGYYDSCSldhkfhtninnGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1273 GNASN-CQTKNYNELDpkkgnkeRNKEWLCKN--IQNTSTDVKQDVCVPPRTQPLCIANMytkQAIVDNAFSSEENMKKA 1349
Cdd:PTZ00176 83 PPARNpCDGRNQNRFD-------ENGESYCNSdkIRGNENNSNAGACAPFRRQNMCDKNL---EYLINKNTENTHDLLGN 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1350 LKAAIKKETELLYTYYTTTKKKTgtpppgFCEAAYRSFNDFKHMVLGDMLWKPESIKKVQEKIGEIIKQ--SGTSGKTVT 1427
Cdd:PTZ00176 153 VLVTAKYEGESIVNNHPDKDKSS------VCTALARSFADIGDIVRGKDMFKRNKHDNVENGLREVFKKiyEGLKNNGAR 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1428 --------------REEWWKQHEVEFWEAAKCGIKDSG----NKSATGDCPRLI-------NDDD--------QFEWWAK 1474
Cdd:PTZ00176 227 ehykevkngnyiklREDWWTANRDQVWKAMTCVAPENAyfrkTEADGIGISSLIlpyskcgRDTDppvvdyipQRLRWMS 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1475 EWSDDFYHKRHEVLKEFDKVCNTDRTGK--NTDCEGTNGQmkansKCKPKCDEYKNFLSKKRDEWNKNFKIYLqtkeEEA 1552
Cdd:PTZ00176 307 EWSEYFCNVLNKEIDEMNNQCKDCEMSRrcNNDTEGEKCK-----KCKEQCQIFKELVSKWKNQFDKQSMKYM----ELY 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1553 NKNTSSVNTKEYSHP-----------------NVYLLYPCTYQNCDNKymtaLLSDKQYGDK------------------ 1597
Cdd:PTZ00176 378 NKASTNITKQNSSAPergyrrnhrrrgydddtNVQLFLKKVIENNECK----VESLGKYLDKtshcgnynfnydntpgsn 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1598 ------------EKICNCDTSKHTQDTDNPCDKNYTE-----YGCTEKKFDKNI--WSSTYVTHP-TDRGKVFAPPRRNS 1657
Cdd:PTZ00176 454 rsnafeitpekfKKACKCKIPNPLEKCPNEENKNVCTrfdkvYSCTSLSFKNDLseWNNSGVKNKeNDNNGVLVPPRRRN 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1658 MCIGwLFSKigdKDSSGKPltkdaaKNQLRLKLIDAARGESHYLHKYYTKNSgtpdtTKYCSALRRSFYDYGDMVKGTDL 1737
Cdd:PTZ00176 534 LCIN-LFSK---KDYKMKD------ENDFKEDLLNAAFSQGKLLGKKYSNYS-----NEAYEAMKFSYADYSDIVKGTDM 598
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1738 WSAgySPRVEKNIYDVFKmpDTAGGntpsdmDIVKDRESWWNTHKREIWQAMNCG--GTNKCDTSGSDYPTVYDSH--DE 1813
Cdd:PTZ00176 599 MND--LKKLNKELNTLLK--ETEKG------DISVDRKTWWDDNKNVVWNAMLCGykTENENQQLNSSWCNVPDDDniDQ 668
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1814 FLRWFIEWGENFCTQKQHYMSELQTICMD----KSCNTLCGGSTCEpCQKQCAKYHKWLFTKKGEWNGqkeKYKEEYKKQ 1889
Cdd:PTZ00176 669 FLRWLTEWAQQYCKEKLIKAHIINTKCKDivegRKHKSMVDITDVE-CKRLFIDYEEWFRYRYNQWKG---LSEKYIKIK 744
|
810 820 830 840
....*....|....*....|....*....|....*....|...
gi 1620185022 1890 GAKYQNIYAHTKKKPDKYIEEYAK--ICEGADLNDVFKRQDNQ 1930
Cdd:PTZ00176 745 KSKNSGVNIPSEECAASYVTKHCNgcICNLRDMEDIHKNINNQ 787
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
1649-1816 |
6.57e-22 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 95.42 E-value: 6.57e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1649 VFAPPRRNSMCIGWLfSKIGDKDSSgkpltkdaAKNQLRLKLIDAAR--GES--HYLHKYYTKNSGTPDTTkyCSALRRS 1724
Cdd:pfam05424 1 ACAPPRRLHLCVKNL-EKINSGNTT--------TTHDLLKAVILAAKyeGFSlwHKYKKKNTKYGDIPSEF--CRQMAYS 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1725 FYDYGDMVKGTDLWSaGYSPR--VEKNIYDVF-KMPDTAGGNTPSDMDIVKDRESWWNTHKREIWQAMNCG-------GT 1794
Cdd:pfam05424 70 FADIGDIIRGKDLYL-GNNKKkkLEENLKKIFkKIYEKLTSKGKDDGNYYQLREDWWEANREDIWKAMTCAltygakyFR 148
|
170 180 190
....*....|....*....|....*....|
gi 1620185022 1795 NKCDTSGS--------DYPTVYDSHDEFLR 1816
Cdd:pfam05424 149 KTCGDGISpstagcndDVPTYFDYVPQFLR 178
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
2035-2199 |
6.76e-22 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 95.42 E-value: 6.76e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2035 VYLPTRKEKICFRGLdgKYDNTPNeVKDEKSLFEHLIKLAAIEGHNLGEYYKAKKgkgqndEKYKYEVSE-CSALKYSFL 2113
Cdd:pfam05424 1 ACAPPRRLHLCVKNL--EKINSGN-TTTTHDLLKAVILAAKYEGFSLWHKYKKKN------TKYGDIPSEfCRQMAYSFA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2114 DLRDIILGHDM--TETDKEETEKNLQKIFKEEYDDDKDAGKPGSTY---RRNFWKSNEKCVWNAMKCG-------YKKGC 2181
Cdd:pfam05424 72 DIGDIIRGKDLylGNNKKKKLEENLKKIFKKIYEKLTSKGKDDGNYyqlREDWWEANREDIWKAMTCAltygakyFRKTC 151
|
170
....*....|....*...
gi 1620185022 2182 DDTTTLSGCDQMPDDTTY 2199
Cdd:pfam05424 152 GDGISPSTAGCNDDVPTY 169
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
2521-2676 |
1.21e-17 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 83.09 E-value: 1.21e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2521 VPPRRKNLC-FPMLYGSKLNKLTLDDFKKHLLNSAATEAKNLMNYHKDNEKLAFQ-------AIKYSFGDYGNLIKGDDL 2592
Cdd:pfam05424 3 APPRRLHLCvKNLEKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGDipsefcrQMAYSFADIGDIIRGKDL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2593 ---NSKNDDIASKINEAITKLQSQNNNSVSSGGGTSAttttkfERKNWWDKNKKHIWHVMLC---------------QYT 2654
Cdd:pfam05424 83 ylgNNKKKKLEENLKKIFKKIYEKLTSKGKDDGNYYQ------LREDWWEANREDIWKAMTCaltygakyfrktcgdGIS 156
|
170 180
....*....|....*....|..
gi 1620185022 2655 GTDKDQHCEDYKEIDNIPQFLR 2676
Cdd:pfam05424 157 PSTAGCNDDVPTYFDYVPQFLR 178
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
2498-2701 |
3.98e-17 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 88.94 E-value: 3.98e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2498 NYDSFENWNKLTLNEKDDNYGVQVPPRRKNLCFPML-YGSKLNKLTLDDFKKHLLNSAATEAKNLMNYHKDNEKLAF-QA 2575
Cdd:PTZ00176 100 NGESYCNSDKIRGNENNSNAGACAPFRRQNMCDKNLeYLINKNTENTHDLLGNVLVTAKYEGESIVNNHPDKDKSSVcTA 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 2576 IKYSFGDYGNLIKGDDLNSKN--DDIASKINEAITKLQSQNNNSVSSGGGTSATTTTKFE-RKNWWDKNKKHIWHVMLCQ 2652
Cdd:PTZ00176 180 LARSFADIGDIVRGKDMFKRNkhDNVENGLREVFKKIYEGLKNNGAREHYKEVKNGNYIKlREDWWTANRDQVWKAMTCV 259
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1620185022 2653 ------YTGTDKDQ--------------HCEDYKEIDNIPQFLRWLEEWARKYCSERTKLADMVSKECK 2701
Cdd:PTZ00176 260 apenayFRKTEADGigisslilpyskcgRDTDPPVVDYIPQRLRWMSEWSEYFCNVLNKEIDEMNNQCK 328
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
492-770 |
4.41e-17 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 88.94 E-value: 4.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 492 GTKKGEVDqnNNEVLLPPRRLDMCTSNLENLARSGQNpdfinngsvNDSFTGDVLLAAKEEAENILKLYGNSNDQSgmCR 571
Cdd:PTZ00176 514 GVKNKEND--NNGVLVPPRRRNLCINLFSKKDYKMKD---------ENDFKEDLLNAAFSQGKLLGKKYSNYSNEA--YE 580
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 572 AVRASFADLGDIIRGTDIWeknDDMKNLQGHLDKIFAKIkdEKGNgkytggenesppYKTLRSDWWSANRDQVWDAIKCQ 651
Cdd:PTZ00176 581 AMKFSYADYSDIVKGTDMM---NDLKKLNKELNTLLKET--EKGD------------ISVDRKTWWDDNKNVVWNAMLCG 643
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 652 IgdlfaasdeKIDRATGKVVGAFCgyndTTPVDDYIPQKLRWLAEWNENYCKQMKKDFNAVKeqcTLCKNIGEGKceKDN 731
Cdd:PTZ00176 644 Y---------KTENENQQLNSSWC----NVPDDDNIDQFLRWLTEWAQQYCKEKLIKAHIIN---TKCKDIVEGR--KHK 705
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1620185022 732 KKCDMCSGMCDTYKENVEKW----KTQWTKHQQQYTSLYSNPN 770
Cdd:PTZ00176 706 SMVDITDVECKRLFIDYEEWfryrYNQWKGLSEKYIKIKKSKN 748
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1117-1480 |
2.51e-14 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 79.69 E-value: 2.51e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1117 EWIHDIENMLDMSKKLIEESCKNLKTK------TTGEKeCTKCNDLCNCFKELKGKIDDQWTKQQNNY------------ 1178
Cdd:PTZ00176 307 EWSEYFCNVLNKEIDEMNNQCKDCEMSrrcnndTEGEK-CKKCKEQCQIFKELVSKWKNQFDKQSMKYmelynkastnit 385
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1179 ------------NHHKDKGKDNMQNLDLdiYLEaECILNEGVKSEKMqsiqGEYEDLDSKC-------DKLRGTEKNyvq 1239
Cdd:PTZ00176 386 kqnssapergyrRNHRRRGYDDDTNVQL--FLK-KVIENNECKVESL----GKYLDKTSHCgnynfnyDNTPGSNRS--- 455
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1240 aliNNSEKDREKICHECENQTtkPSPTDKCDGIGNASNCQTKNYNELDPKKGNKERNKEWLCKNIQNTSTDvKQDVCVPP 1319
Cdd:PTZ00176 456 ---NAFEITPEKFKKACKCKI--PNPLEKCPNEENKNVCTRFDKVYSCTSLSFKNDLSEWNNSGVKNKEND-NNGVLVPP 529
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1320 RTQPLCIaNMYTKQaivDNAFSSEENMKKALKAAIKKETELLYTYYTTTKKKTGtpppgfcEAAYRSFNDFKHMVLG-DM 1398
Cdd:PTZ00176 530 RRRNLCI-NLFSKK---DYKMKDENDFKEDLLNAAFSQGKLLGKKYSNYSNEAY-------EAMKFSYADYSDIVKGtDM 598
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1399 LwkpESIKKVQEKIGEIIKQSGTSGKTVTREEWWKQHEVEFWEAAKCGIK-DSGNKSATGDCPRLINDD--DQFEWWAKE 1475
Cdd:PTZ00176 599 M---NDLKKLNKELNTLLKETEKGDISVDRKTWWDDNKNVVWNAMLCGYKtENENQQLNSSWCNVPDDDniDQFLRWLTE 675
|
....*
gi 1620185022 1476 WSDDF 1480
Cdd:PTZ00176 676 WAQQY 680
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
1315-1459 |
5.61e-07 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 52.28 E-value: 5.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 1315 VCVPPRTQPLCIANMytkQAIVDNAFSSEENMKKALKAAIKKETELLYTYYTTTKKKTGTPPPGFCEAAYRSFNDFKHMV 1394
Cdd:pfam05424 1 ACAPPRRLHLCVKNL---EKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGDIPSEFCRQMAYSFADIGDII 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1620185022 1395 LG-DMLWKPESIKKVQEKIGEIIKQSG---------TSGKTVTREEWWKQHEVEFWEAAKCGIKDSGNKSATGDC 1459
Cdd:pfam05424 78 RGkDLYLGNNKKKKLEENLKKIFKKIYekltskgkdDGNYYQLREDWWEANREDIWKAMTCALTYGAKYFRKTCG 152
|
|
| PFEMP |
pfam03011 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
913-1041 |
2.14e-06 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
Pssm-ID: 281064 Cd Length: 154 Bit Score: 49.80 E-value: 2.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620185022 913 FEDWLTSFFNEQQNVKSKSSDCTNitPSSGDCDGKKCRDKCPCYEKWVKRKTNEWRHFKNYYRDFQTINPTKWMSS---- 988
Cdd:pfam03011 2 FKRWVEYFLEDSIKWRKKLKSCIN--NGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGLTGKTLdeyl 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1620185022 989 -----------FKSVGNDADTYVKKKKQSELSKAYQSTSGTKS-----NNITIQDILTEESKKVTECLK 1041
Cdd:pfam03011 80 dlksfletflfYIDIKEAYGDVKELKKLEEILDEEGCSAGAESaknnkNEDAIDKLLDKEEKKANNCKE 148
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