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Conserved domains on  [gi|1720427093|ref|XP_030099322|]
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transcriptional repressor p66 alpha isoform X2 [Mus musculus]

Protein Classification

transcriptional repressor p66A/B( domain architecture ID 13098782)

transcriptional repressor p66A and p66B includes the coiled-coil and interaction region (P66-CC) and a GATA zinc finger which uses four cysteine residues to coordinate a zinc ion, and bind to DNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P66_CC pfam16563
Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short ...
 133-172 1.95e-16

Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short coiled-coil interaction region on the transcriptional repressors P66A and P66B. The P66A and B, or alpha and beta, complex with MBDs or methyl-binding domain-containing proteins via a coiled-coil region on each. This P66-MBD2 complex forms part of an assembly with NuRD, nucleosome remodelling and deacetylation protein. MBD2-NuRD binds methylated DNA and regulates transcription of eg, the foetal beta-globin gene during development.


:

Pssm-ID: 465178  Cd Length: 40  Bit Score: 73.22  E-value: 1.95e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1720427093 133 SPEERERMIKQLKEELRLEEAKLVLLKKLRQSQIQKEATA 172
Cdd:pfam16563   1 EIEERERMIKKLREELRLEEAKLVLLKKLRQSQQQKENIV 40
ZnF_GATA super family cl29608
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 419-452 3.05e-06

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


The actual alignment was detected with superfamily member pfam00320:

Pssm-ID: 453031 [Multi-domain]  Cd Length: 36  Bit Score: 44.23  E-value: 3.05e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1720427093 419 CVQCKTDFTCRWRE--KGGAVMCENCMTSNQKKALK 452
Cdd:pfam00320   1 CSNCGTTKTPLWRRgpNGNRTLCNACGLYYKKKGLK 36
Med21 super family cl12769
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 90-163 9.10e-03

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


The actual alignment was detected with superfamily member pfam11221:

Pssm-ID: 463241  Cd Length: 134  Bit Score: 36.80  E-value: 9.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427093  90 SEKRPPSPDVIVLSDSEQPSSPRVngL-TTVALKDTSTEAL------LKSSPEERERMIKQLKEELRLEEAKLV------ 156
Cdd:pfam11221  41 PDKAPPQPEPEPDPPEEFEATQRE--LaRDLILKAQQIEYLidslpgIGVSEEEQLQRIKELEEELREAEEERQeavkek 118


                  ....*....
gi 1720427093 157 --LLKKLRQ 163
Cdd:pfam11221 119 eeLLKKLDE 127
 
Name Accession Description Interval E-value
P66_CC pfam16563
Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short ...
 133-172 1.95e-16

Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short coiled-coil interaction region on the transcriptional repressors P66A and P66B. The P66A and B, or alpha and beta, complex with MBDs or methyl-binding domain-containing proteins via a coiled-coil region on each. This P66-MBD2 complex forms part of an assembly with NuRD, nucleosome remodelling and deacetylation protein. MBD2-NuRD binds methylated DNA and regulates transcription of eg, the foetal beta-globin gene during development.


Pssm-ID: 465178  Cd Length: 40  Bit Score: 73.22  E-value: 1.95e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1720427093 133 SPEERERMIKQLKEELRLEEAKLVLLKKLRQSQIQKEATA 172
Cdd:pfam16563   1 EIEERERMIKKLREELRLEEAKLVLLKKLRQSQQQKENIV 40
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 419-452 3.05e-06

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 44.23  E-value: 3.05e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1720427093 419 CVQCKTDFTCRWRE--KGGAVMCENCMTSNQKKALK 452
Cdd:pfam00320   1 CSNCGTTKTPLWRRgpNGNRTLCNACGLYYKKKGLK 36
Med21 pfam11221
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 90-163 9.10e-03

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


Pssm-ID: 463241  Cd Length: 134  Bit Score: 36.80  E-value: 9.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427093  90 SEKRPPSPDVIVLSDSEQPSSPRVngL-TTVALKDTSTEAL------LKSSPEERERMIKQLKEELRLEEAKLV------ 156
Cdd:pfam11221  41 PDKAPPQPEPEPDPPEEFEATQRE--LaRDLILKAQQIEYLidslpgIGVSEEEQLQRIKELEEELREAEEERQeavkek 118


                  ....*....
gi 1720427093 157 --LLKKLRQ 163
Cdd:pfam11221 119 eeLLKKLDE 127
 
Name Accession Description Interval E-value
P66_CC pfam16563
Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short ...
 133-172 1.95e-16

Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short coiled-coil interaction region on the transcriptional repressors P66A and P66B. The P66A and B, or alpha and beta, complex with MBDs or methyl-binding domain-containing proteins via a coiled-coil region on each. This P66-MBD2 complex forms part of an assembly with NuRD, nucleosome remodelling and deacetylation protein. MBD2-NuRD binds methylated DNA and regulates transcription of eg, the foetal beta-globin gene during development.


Pssm-ID: 465178  Cd Length: 40  Bit Score: 73.22  E-value: 1.95e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1720427093 133 SPEERERMIKQLKEELRLEEAKLVLLKKLRQSQIQKEATA 172
Cdd:pfam16563   1 EIEERERMIKKLREELRLEEAKLVLLKKLRQSQQQKENIV 40
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 419-452 3.05e-06

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 44.23  E-value: 3.05e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1720427093 419 CVQCKTDFTCRWRE--KGGAVMCENCMTSNQKKALK 452
Cdd:pfam00320   1 CSNCGTTKTPLWRRgpNGNRTLCNACGLYYKKKGLK 36
Med21 pfam11221
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 90-163 9.10e-03

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


Pssm-ID: 463241  Cd Length: 134  Bit Score: 36.80  E-value: 9.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427093  90 SEKRPPSPDVIVLSDSEQPSSPRVngL-TTVALKDTSTEAL------LKSSPEERERMIKQLKEELRLEEAKLV------ 156
Cdd:pfam11221  41 PDKAPPQPEPEPDPPEEFEATQRE--LaRDLILKAQQIEYLidslpgIGVSEEEQLQRIKELEEELREAEEERQeavkek 118


                  ....*....
gi 1720427093 157 --LLKKLRQ 163
Cdd:pfam11221 119 eeLLKKLDE 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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